Snake_Venom_sequencing_Indaba_Practical_2024.ipynb

{
  "cells": [
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "view-in-github",
        "colab_type": "text"
      },
      "source": [
        "<a href=\"https://colab.research.google.com/github/BioGeek/hackathon_indaba_senegal_2024/blob/main/Snake_Venom_sequencing_Indaba_Practical_2024.ipynb\" target=\"_parent\"><img src=\"https://colab.research.google.com/assets/colab-badge.svg\" alt=\"Open In Colab\"/></a>"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "m2s4kN_QPQVe"
      },
      "source": [
        "# Snake venom sequencing tutorial 🔬\n",
        "\n",
        "<!-- Image courtesy of David Goodsell, see https://ccsb.scripps.edu/goodsell/ for more gorgeous illustrations! -->\n",
        "\n",
        "<a href=\"https://colab.research.google.com/github/deep-learning-indaba/indaba-pracs-2023/blob/main/practicals/ML_for_Bio_Indaba_Practical_2023.ipynb\" target=\"_parent\"><img src=\"https://colab.research.google.com/assets/colab-badge.svg\" alt=\"Open In Colab\"/></a>\n",
        "\n",
        "© Deep Learning Indaba 2024. Apache License 2.0.\n",
        "\n",
        "\n",
        "**Aims/Learning Objectives:**\n",
        "\n",
        "1. Learn the basics of proteins (e.g. what is a protein, what is it made of?) 🧪\n",
        "2. Very Gentle introduction to the Snake Hackathon Dataset\n",
        "\n",
        "**Prerequisites:**\n",
        "\n",
        "1. Basic ML knowledge and Python\n",
        "2. Basic Bio is beneficial\n",
        "\n",
        "For this practical, you will need to use a GPU to speed up training. To do this, go to the \"Runtime\" menu in Colab, select \"Change runtime type\" and then in the popup menu, choose \"GPU\" in the \"Hardware accelerator\" box.\n"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "4boGA9rYdt9l"
      },
      "outputs": [],
      "source": [
        "## Install and import anything required. Capture hides the output from the cell.\n",
        "# @title Install and import required packages. (Run Cell)\n",
        "%%capture\n",
        "!pip install -qU py3Dmol\n",
        "!pip install transformers datasets\n",
        "\n",
        "import torch\n",
        "import matplotlib.pyplot as plt\n",
        "import numpy as np\n",
        "import pandas as pd\n",
        "\n",
        "# import tensorflow as tf\n",
        "# import optax\n",
        "# import tensorflow_datasets as tfds"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "Il11H3cNRtmg",
        "outputId": "59a25b32-f390-4f09-9471-aaa99a1787b5"
      },
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Found 1 CUDA devices of type Tesla T4.\n"
          ]
        }
      ],
      "source": [
        "# @title Check TPU/GPU. (Run Cell)\n",
        "num_devices = torch.cuda.device_count()\n",
        "device_type = torch.cuda.get_device_name(0) if num_devices > 0 else \"CPU\"\n",
        "\n",
        "print(f\"Found {num_devices} CUDA devices of type {device_type}.\")"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "-ZUp8i37dFbU"
      },
      "source": [
        "# 1. **The Wonderous World of Biology**\n",
        "\n",
        "\n",
        "\n"
      ]
    },
    {
      "cell_type": "markdown",
      "source": [
        "\n",
        "Why did the snake get into machine learning?\n",
        "\n",
        "Because it heard optimize its \"python\" code in biology and make it \"scale\"!\n",
        "\n",
        "\n",
        "In this tutorial, we will start with a gentle intro to proteins based on the great tutorial on [ML for Biology from DLI 2023](https://github.com/deep-learning-indaba/indaba-pracs-2023/blob/main/practicals/ML_for_Bio_Indaba_Practical_2023.ipynb) to finally understand how scientists manage to sequence snake venoms using mass spectrometry.\n"
      ],
      "metadata": {
        "id": "bT9LkiDe78a_"
      }
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "ii__Bc27epiJ"
      },
      "source": [
        "## 1.1 What is a Protein?"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "4PbcFsfAibBu"
      },
      "source": [
        "Proteins are **large**, **complex molecules** that play many critical roles in the body. They are required for the structure, function, and regulation of the body's tissues and organs.\n",
        "\n",
        "Proteins are molecules in 3D space, but they are made up of linear elements called **amino acids** or **residues**. For example, take the protein **insulin**, which is a relatively small protein of only 110 amino acids that is important for facilitating sugar uptake from the bloodstream into cells. It is formed of 2 separate chains of amino acids (shown in red and blue below) that are bound together.\n"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "xjZsrPcNfjxj"
      },
      "source": [
        "Each amino acid has its own physical structure and properties – for example, some amino acids are positively charged while others are negatively charged. These biophysical properties have repurcussions for the overall protein structure and functon.\n",
        "\n",
        "Here is a list of the 20 amino acid building components that make up proteins:\n",
        "\n",
        "<!-- ![](https://upload.wikimedia.org/wikipedia/commons/4/4e/Proteinogenic_Amino_Acid_Table.png) -->\n",
        "\n",
        "![](https://i0.wp.com/www.compoundchem.com/wp-content/uploads/2014/09/20-Common-Amino-Acids-v3.png?ssl=1)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "h-D15mUvU21S"
      },
      "source": [
        "🥜 **In a nutshell**:\n",
        "- Proteins are made up of **sequences of amino acids**, each of which have their own unique properities which influences the 3D shape."
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "j9FiouLxJr68"
      },
      "source": [
        "## 1.2 Why are Proteins Important?\n",
        "\n"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "aItYx_WMpGcA"
      },
      "source": [
        "Proteins do most of their work in the cell and perform crucial functions in the body. They transport molecules from one place to another, form the structure of our cells, communicate signals within the cell and between cells, speed up chemical reactions, control cell growth and differentiation, and defend against foreign invaders.\n",
        "\n",
        "These varying roles are a result of the diverse structures of proteins. Even a slight change in structure can render a protein nonfunctional."
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "AnAJXXrTO4fN"
      },
      "source": [
        "## 1.3 Protein Structures\n",
        "\n",
        "\n",
        "\n",
        "\n"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "GSP_bYIDfgw0"
      },
      "source": [
        "In general, proteins have four forms:\n",
        "\n",
        "<img src=\"https://comis.med.uvm.edu/VIC/coursefiles/MD540/MD540-Protein_Organization_10400_574581210/Protein-org/structure.jpg\"/>\n",
        "\n",
        "1. **Primary structure**: sequence of amino acids that make up the protein, like **letters in a sentence**. For example, the sequence \"AUGC\" represents a protein made up of residues `A`, `U`, `G` and `C` in the same way that \"HELLO\" represents a word made up of letters `H`, `E`, `L` and `O`.\n",
        "\n",
        "\n",
        "2. **Secondary structure**: local interactions between nearby residues cause specific sub-structures to form. Two common secondary structures are α-helices (coiled like a spring) and β-sheets (folded like an accordion).\n",
        "\n",
        "<img src=\"https://www.creative-proteomics.com/pronalyse/images/1-4-1-Secondary-Structure-Analysis_Fig1.jpg\"/>\n",
        "\n",
        "\n",
        "3. **Tertiary structure**: the full, three-dimensional shape of a single protein chain. This structure is the result of distant amino acids interacting and folding together.\n",
        "\n",
        "4. **Quaternary**: proteins made up of multiple polypeptide chains, or subunits, coming together like pieces of a puzzle. These subunits can be identical or different.\n"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "JmJelCR4Pz8M"
      },
      "source": [
        "**Group Task:**\n",
        "\n",
        "Execute the cell below which visualise a protein structure of a **three finger toxin from snake Hemachatus venom**\n",
        "Snake venoms are rich sources of biologically active proteins and polypeptides. Three-finger toxins are non-enzymatic proteins present in elapid (cobras, kraits, mambas and sea snakes) and colubrid venoms."
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 497
        },
        "id": "_xC0Ci4zPypd",
        "outputId": "1320d0c6-71f7-4aac-c114-38e6315ffb52"
      },
      "outputs": [
        {
          "output_type": "display_data",
          "data": {
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                                                           \\nCOMPND   2 MOLECULE: CYTOTOXIN 1;                                               \\nCOMPND   3 CHAIN: A, B;                                                         \\nCOMPND   4 SYNONYM: HEMOLYTIC PROTEIN 12B, THREE FINGER TOXIN                   \\nSOURCE    MOL_ID: 1;                                                            \\nSOURCE   2 ORGANISM_SCIENTIFIC: HEMACHATUS HAEMACHATUS;                         \\nSOURCE   3 ORGANISM_COMMON: RINGHALS;                                           \\nSOURCE   4 ORGANISM_TAXID: 8626                                                 \\nKEYWDS    THREE FINGER TOXIN, VENOM TOXIN, TOXIN                                \\nEXPDTA    X-RAY DIFFRACTION                                                     \\nAUTHOR    C.JOBICHEN,J.SIVARAMAN                                                \\nREVDAT   3   08-NOV-23 3VTS    1       REMARK                                   \\nREVDAT   2   27-NOV-13 3VTS    1       JRNL                                     \\nREVDAT   1   07-NOV-12 3VTS    0                                                \\nJRNL        AUTH   V.M.GIRISH,S.KUMAR,L.JOSEPH,C.JOBICHEN,R.M.KINI,J.SIVARAMAN  \\nJRNL        TITL   IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF A NEW      \\nJRNL        TITL 2 THREE-FINGER TOXIN HEMACHATOXIN FROM HEMACHATUS HAEMACHATUS  \\nJRNL        TITL 3 VENOM.                                                       \\nJRNL        REF    PLOS ONE                      V.   7 48112 2012              \\nJRNL        REFN                   ESSN 1932-6203                               \\nJRNL        PMID   23144733                                                     \\nJRNL        DOI    10.1371/JOURNAL.PONE.0048112                                 \\nREMARK   2                                                                      \\nREMARK   2 RESOLUTION.    2.43 ANGSTROMS.                                       \\nREMARK   3                                                                      \\nREMARK   3 REFINEMENT.                                                          \\nREMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.7.3_928)                    \\nREMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            \\nREMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           \\nREMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            \\nREMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              \\nREMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               \\nREMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           \\nREMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  \\nREMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  \\nREMARK   3                                                                      \\nREMARK   3    REFINEMENT TARGET : ML                                            \\nREMARK   3                                                                      \\nREMARK   3  DATA USED IN REFINEMENT.                                            \\nREMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.43                           \\nREMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 30.11                          \\nREMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.350                          \\nREMARK   3   COMPLETENESS FOR RANGE        (%) : 96.6                           \\nREMARK   3   NUMBER OF REFLECTIONS             : 5614                           \\nREMARK   3                                                                      \\nREMARK   3  FIT TO DATA USED IN REFINEMENT.                                     \\nREMARK   3   R VALUE     (WORKING + TEST SET) : 0.237                           \\nREMARK   3   R VALUE            (WORKING SET) : 0.232                           \\nREMARK   3   FREE R VALUE                     : 0.281                           \\nREMARK   3   FREE R VALUE TEST SET SIZE   (%) : 10.210                          \\nREMARK   3   FREE R VALUE TEST SET COUNT      : 573                             \\nREMARK   3                                                                      \\nREMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           \\nREMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        \\nREMARK   3     1 30.1147 -  3.8493    0.93     1265   148  0.1914 0.2082        \\nREMARK   3     2  3.8493 -  3.0562    0.97     1263   138  0.2437 0.3212        \\nREMARK   3     3  3.0562 -  2.6702    0.99     1271   148  0.2594 0.3343        \\nREMARK   3     4  2.6702 -  2.4261    0.97     1242   139  0.3162 0.3916        \\nREMARK   3                                                                      \\nREMARK   3  BULK SOLVENT MODELLING.                                             \\nREMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       \\nREMARK   3   SOLVENT RADIUS     : 1.20                                          \\nREMARK   3   SHRINKAGE RADIUS   : 0.98                                          \\nREMARK   3   K_SOL              : 0.29                                          \\nREMARK   3   B_SOL              : 19.33                                         \\nREMARK   3                                                                      \\nREMARK   3  ERROR ESTIMATES.                                                    \\nREMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.410            \\nREMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 29.360           \\nREMARK   3                                                                      \\nREMARK   3  B VALUES.                                                           \\nREMARK   3   FROM WILSON PLOT           (A**2) : NULL                           \\nREMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           \\nREMARK   3   OVERALL ANISOTROPIC B VALUE.                                       \\nREMARK   3    B11 (A**2) : 1.94010                                              \\nREMARK   3    B22 (A**2) : 4.56620                                              \\nREMARK   3    B33 (A**2) : -5.46690                                             \\nREMARK   3    B12 (A**2) : 0.00000                                              \\nREMARK   3    B13 (A**2) : 0.00000                                              \\nREMARK   3    B23 (A**2) : 0.00000                                              \\nREMARK   3                                                                      \\nREMARK   3  TWINNING INFORMATION.                                               \\nREMARK   3   FRACTION: NULL                                                     \\nREMARK   3   OPERATOR: NULL                                                     \\nREMARK   3                                                                      \\nREMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       \\nREMARK   3                 RMSD          COUNT                                  \\nREMARK   3   BOND      :  0.008            960                                  \\nREMARK   3   ANGLE     :  1.377           1272                                  \\nREMARK   3   CHIRALITY :  0.088            150                                  \\nREMARK   3   PLANARITY :  0.006            154                                  \\nREMARK   3   DIHEDRAL  : 13.951            392                                  \\nREMARK   3                                                                      \\nREMARK   3  TLS DETAILS                                                         \\nREMARK   3   NUMBER OF TLS GROUPS  : 1                                          \\nREMARK   3   TLS GROUP : 1                                                      \\nREMARK   3    SELECTION: ALL                                                    \\nREMARK   3    ORIGIN FOR THE GROUP (A):  61.4575  56.8640   9.0170              \\nREMARK   3    T TENSOR                                                          \\nREMARK   3      T11:   0.1738 T22:   0.2887                                     \\nREMARK   3      T33:   0.1768 T12:   0.0037                                     \\nREMARK   3      T13:  -0.0101 T23:   0.0331                                     \\nREMARK   3    L TENSOR                                                          \\nREMARK   3      L11:   1.9536 L22:   1.1002                                     \\nREMARK   3      L33:   1.2418 L12:  -0.4658                                     \\nREMARK   3      L13:  -0.2144 L23:   0.1753                                     \\nREMARK   3    S TENSOR                                                          \\nREMARK   3      S11:  -0.1041 S12:  -0.0023 S13:  -0.0502                       \\nREMARK   3      S21:   0.0104 S22:   0.0572 S23:   0.0982                       \\nREMARK   3      S31:  -0.0512 S32:  -0.0039 S33:   0.0483                       \\nREMARK   3                                                                      \\nREMARK   3  NCS DETAILS                                                         \\nREMARK   3   NUMBER OF NCS GROUPS : 1                                           \\nREMARK   3   NCS GROUP : 1                                                      \\nREMARK   3    NCS OPERATOR : 1                                                  \\nREMARK   3     REFERENCE SELECTION: CHAIN A AND (RESSEQ 1:61 )                  \\nREMARK   3     SELECTION          : CHAIN B AND (RESSEQ 1:61 )                  \\nREMARK   3     ATOM PAIRS NUMBER  : 469                                         \\nREMARK   3     RMSD               : 0.063                                       \\nREMARK   3                                                                      \\nREMARK   3  OTHER REFINEMENT REMARKS: NULL                                      \\nREMARK   4                                                                      \\nREMARK   4 3VTS COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         \\nREMARK 100                                                                      \\nREMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 14-JUN-12.                  \\nREMARK 100 THE DEPOSITION ID IS D_1000095490.                                   \\nREMARK 200                                                                      \\nREMARK 200 EXPERIMENTAL DETAILS                                                 \\nREMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  \\nREMARK 200  DATE OF DATA COLLECTION        : 31-OCT-08                          \\nREMARK 200  TEMPERATURE           (KELVIN) : 100                                \\nREMARK 200  PH                             : 4.5                                \\nREMARK 200  NUMBER OF CRYSTALS USED        : 1                                  \\nREMARK 200                                                                      \\nREMARK 200  SYNCHROTRON              (Y/N) : N                                  \\nREMARK 200  RADIATION SOURCE               : ROTATING ANODE                     \\nREMARK 200  BEAMLINE                       : NULL                               \\nREMARK 200  X-RAY GENERATOR MODEL          : RIGAKU                             \\nREMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  \\nREMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418                             \\nREMARK 200  MONOCHROMATOR                  : GRAPHITE                           \\nREMARK 200  OPTICS                         : MIRRORS                            \\nREMARK 200                                                                      \\nREMARK 200  DETECTOR TYPE                  : IMAGE PLATE                        \\nREMARK 200  DETECTOR MANUFACTURER          : RIGAKU RAXIS IV++                  \\nREMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           \\nREMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           \\nREMARK 200                                                                      \\nREMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 5614                               \\nREMARK 200  RESOLUTION RANGE HIGH      (A) : 2.426                              \\nREMARK 200  RESOLUTION RANGE LOW       (A) : 30.112                             \\nREMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.000                              \\nREMARK 200                                                                      \\nREMARK 200 OVERALL.                                                             \\nREMARK 200  COMPLETENESS FOR RANGE     (%) : 96.2                               \\nREMARK 200  DATA REDUNDANCY                : 3.900                              \\nREMARK 200  R MERGE                    (I) : 0.06400                            \\nREMARK 200  R SYM                      (I) : NULL                               \\nREMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 20.6000                            \\nREMARK 200                                                                      \\nREMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     \\nREMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL                     \\nREMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL                     \\nREMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               \\nREMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               \\nREMARK 200  R MERGE FOR SHELL          (I) : NULL                               \\nREMARK 200  R SYM FOR SHELL            (I) : NULL                               \\nREMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               \\nREMARK 200                                                                      \\nREMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              \\nREMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        \\nREMARK 200 SOFTWARE USED: PHASER                                                \\nREMARK 200 STARTING MODEL: 1TGX                                                 \\nREMARK 200                                                                      \\nREMARK 200 REMARK: NULL                                                         \\nREMARK 280                                                                      \\nREMARK 280 CRYSTAL                                                              \\nREMARK 280 SOLVENT CONTENT, VS   (%): 53.09                                     \\nREMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.62                     \\nREMARK 280                                                                      \\nREMARK 280 CRYSTALLIZATION CONDITIONS: 150MM AMMONIUM ACETATE, 100MM SODIUM     \\nREMARK 280  ACETATE, 25% POLYETHYLENE GLYCOL 4000 , PH 4.5, VAPOR DIFFUSION,    \\nREMARK 280  HANGING DROP, TEMPERATURE 298K                                      \\nREMARK 290                                                                      \\nREMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            \\nREMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       \\nREMARK 290                                                                      \\nREMARK 290      SYMOP   SYMMETRY                                                \\nREMARK 290     NNNMMM   OPERATOR                                                \\nREMARK 290       1555   X,Y,Z                                                   \\nREMARK 290       2555   -X+1/2,-Y,Z+1/2                                         \\nREMARK 290       3555   -X,Y+1/2,-Z+1/2                                         \\nREMARK 290       4555   X+1/2,-Y+1/2,-Z                                         \\nREMARK 290                                                                      \\nREMARK 290     WHERE NNN -> OPERATOR NUMBER                                     \\nREMARK 290           MMM -> TRANSLATION VECTOR                                  \\nREMARK 290                                                                      \\nREMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            \\nREMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             \\nREMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                \\nREMARK 290 RELATED MOLECULES.                                                   \\nREMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            \\nREMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            \\nREMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            \\nREMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       24.85900            \\nREMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            \\nREMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       28.90650            \\nREMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            \\nREMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       25.02850            \\nREMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       28.90650            \\nREMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       24.85900            \\nREMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       25.02850            \\nREMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            \\nREMARK 290                                                                      \\nREMARK 290 REMARK: NULL                                                         \\nREMARK 300                                                                      \\nREMARK 300 BIOMOLECULE: 1                                                       \\nREMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                \\nREMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  \\nREMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               \\nREMARK 300 BURIED SURFACE AREA.                                                 \\nREMARK 350                                                                      \\nREMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           \\nREMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                \\nREMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          \\nREMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          \\nREMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               \\nREMARK 350                                                                      \\nREMARK 350 BIOMOLECULE: 1                                                       \\nREMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           \\nREMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    \\nREMARK 350 SOFTWARE USED: PISA                                                  \\nREMARK 350 TOTAL BURIED SURFACE AREA: 1160 ANGSTROM**2                          \\nREMARK 350 SURFACE AREA OF THE COMPLEX: 7460 ANGSTROM**2                        \\nREMARK 350 CHANGE IN SOLVENT FREE ENERGY: -8.0 KCAL/MOL                         \\nREMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  \\nREMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            \\nREMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            \\nREMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            \\nREMARK 500                                                                      \\nREMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         \\nREMARK 500 SUBTOPIC: TORSION ANGLES                                             \\nREMARK 500                                                                      \\nREMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            \\nREMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               \\nREMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             \\nREMARK 500                                                                      \\nREMARK 500 STANDARD TABLE:                                                      \\nREMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    \\nREMARK 500                                                                      \\nREMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           \\nREMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            \\nREMARK 500                                                                      \\nREMARK 500  M RES CSSEQI        PSI       PHI                                   \\nREMARK 500    PHE A  10      -54.71     71.86                                   \\nREMARK 500    PHE B  10      -53.63     71.59                                   \\nREMARK 500                                                                      \\nREMARK 500 REMARK: NULL                                                         \\nREMARK 999                                                                      \\nREMARK 999 SEQUENCE                                                             \\nREMARK 999 THE AUTHOR DEPOSITED SEQUENCE OF THIS PROTEIN AS THE CODE B3EWH9     \\nREMARK 999 BUT IT DOES NOT APPEAR IN TE SEQUENCE DATABASE YET.                  \\nDBREF  3VTS A    1    61  PDB    3VTS     3VTS             1     61             \\nDBREF  3VTS B    1    61  PDB    3VTS     3VTS             1     61             \\nSEQRES   1 A   61  LEU LYS CYS HIS ASN LYS LEU VAL PRO PHE LEU SER LYS          \\nSEQRES   2 A   61  THR CYS PRO GLU GLY LYS ASN LEU CYS TYR LYS MET THR          \\nSEQRES   3 A   61  LEU MET LYS MET PRO LYS ILE PRO ILE LYS ARG GLY CYS          \\nSEQRES   4 A   61  THR ASP ALA CYS PRO LYS SER SER LEU LEU VAL LYS VAL          \\nSEQRES   5 A   61  VAL CYS CYS ASN LYS ASP LYS CYS ASN                          \\nSEQRES   1 B   61  LEU LYS CYS HIS ASN LYS LEU VAL PRO PHE LEU SER LYS          \\nSEQRES   2 B   61  THR CYS PRO GLU GLY LYS ASN LEU CYS TYR LYS MET THR          \\nSEQRES   3 B   61  LEU MET LYS MET PRO LYS ILE PRO ILE LYS ARG GLY CYS          \\nSEQRES   4 B   61  THR ASP ALA CYS PRO LYS SER SER LEU LEU VAL LYS VAL          \\nSEQRES   5 B   61  VAL CYS CYS ASN LYS ASP LYS CYS ASN                          \\nFORMUL   3  HOH   *49(H2 O)                                                     \\nSHEET    1   A 2 LYS A   2  HIS A   4  0                                        \\nSHEET    2   A 2 SER A  12  THR A  14 -1  O  LYS A  13   N  CYS A   3           \\nSHEET    1   B 3 MET A  30  THR A  40  0                                        \\nSHEET    2   B 3 LEU A  21  LEU A  27 -1  N  MET A  25   O  ILE A  35           \\nSHEET    3   B 3 VAL A  50  CYS A  55 -1  O  CYS A  55   N  CYS A  22           \\nSHEET    1   C 2 LYS B   2  HIS B   4  0                                        \\nSHEET    2   C 2 SER B  12  THR B  14 -1  O  LYS B  13   N  CYS B   3           \\nSHEET    1   D 3 MET B  30  THR B  40  0                                        \\nSHEET    2   D 3 LEU B  21  LEU B  27 -1  N  MET B  25   O  ILE B  35           \\nSHEET    3   D 3 VAL B  50  CYS B  55 -1  O  CYS B  55   N  CYS B  22           \\nSSBOND   1 CYS A    3    CYS A   22                          1555   1555  2.04  \\nSSBOND   2 CYS A   15    CYS A   39                          1555   1555  2.04  \\nSSBOND   3 CYS A   43    CYS A   54                          1555   1555  2.03  \\nSSBOND   4 CYS A   55    CYS A   60                          1555   1555  2.05  \\nSSBOND   5 CYS B    3    CYS B   22                          1555   1555  2.02  \\nSSBOND   6 CYS B   15    CYS B   39                          1555   1555  2.04  \\nSSBOND   7 CYS B   43    CYS B   54                          1555   1555  2.04  \\nSSBOND   8 CYS B   55    CYS B   60                          1555   1555  2.02  \\nCRYST1   49.718   50.057   57.813  90.00  90.00  90.00 P 21 21 21    8          \\nORIGX1      1.000000  0.000000  0.000000        0.00000                         \\nORIGX2      0.000000  1.000000  0.000000        0.00000                         \\nORIGX3      0.000000  0.000000  1.000000        0.00000                         \\nSCALE1      0.020113  0.000000  0.000000        0.00000                         \\nSCALE2      0.000000  0.019977  0.000000        0.00000                         \\nSCALE3      0.000000  0.000000  0.017297        0.00000                         \\nATOM      1  N   LEU A   1      73.350  41.259  12.373  1.00 31.31           N  \\nANISOU    1  N   LEU A   1     3437   4478   3981    788    346    646       N  \\nATOM      2  CA  LEU A   1      72.878  41.778  11.093  1.00 45.01           C  \\nANISOU    2  CA  LEU A   1     5169   6206   5728    674    333    531       C  \\nATOM      3  C   LEU A   1      73.619  43.058  10.733  1.00 42.35           C  \\nANISOU    3  C   LEU A   1     4792   6014   5285    633    268    472       C  \\nATOM      4  O   LEU A   1      73.902  43.890  11.599  1.00 41.66           O  \\nANISOU    4  O   LEU A   1     4694   6022   5115    649    226    513       O  \\nATOM      5  CB  LEU A   1      71.353  42.030  11.114  1.00 27.18           C  \\nANISOU    5  CB  LEU A   1     2946   3884   3496    590    347    537       C  \\nATOM      6  CG  LEU A   1      70.770  42.663   9.833  1.00 42.92           C  \\nANISOU    6  CG  LEU A   1     4936   5888   5485    480    322    426       C  \\nATOM      7  CD1 LEU A   1      70.977  41.760   8.619  1.00 23.59           C  \\nANISOU    7  CD1 LEU A   1     2480   3368   3116    468    349    332       C  \\nATOM      8  CD2 LEU A   1      69.287  43.077   9.964  1.00 22.69           C  \\nANISOU    8  CD2 LEU A   1     2395   3288   2936    406    324    436       C  \\nATOM      9  N   LYS A   2      73.932  43.201   9.451  1.00 29.48           N  \\nANISOU    9  N   LYS A   2     3140   4399   3661    580    265    374       N  \\nATOM     10  CA  LYS A   2      74.511  44.433   8.925  1.00 42.24           C  \\nANISOU   10  CA  LYS A   2     4722   6135   5192    521    218    322       C  \\nATOM     11  C   LYS A   2      73.568  45.067   7.904  1.00 34.75           C  \\nANISOU   11  C   LYS A   2     3798   5172   4232    415    209    261       C  \\nATOM     12  O   LYS A   2      73.049  44.389   7.016  1.00 41.19           O  \\nANISOU   12  O   LYS A   2     4630   5918   5102    392    239    205       O  \\nATOM     13  CB  LYS A   2      75.874  44.161   8.268  1.00 33.86           C  \\nANISOU   13  CB  LYS A   2     3603   5134   4127    560    225    271       C  \\nATOM     14  CG  LYS A   2      77.015  43.863   9.236  1.00 35.77           C  \\nANISOU   14  CG  LYS A   2     3799   5436   4356    664    212    325       C  \\nATOM     15  CD  LYS A   2      78.349  44.239   8.618  1.00 54.23           C  \\nANISOU   15  CD  LYS A   2     6059   7885   6660    666    199    269       C  \\nATOM     16  CE  LYS A   2      79.518  43.602   9.355  1.00 65.63           C  \\nANISOU   16  CE  LYS A   2     7446   9378   8115    788    194    307       C  \\nATOM     17  NZ  LYS A   2      79.751  42.175   8.963  1.00 53.02           N  \\nANISOU   17  NZ  LYS A   2     5853   7688   6604    877    251    297       N  \\nATOM     18  N   CYS A   3      73.352  46.368   8.023  1.00 32.68           N  \\nANISOU   18  N   CYS A   3     3538   4977   3902    356    167    266       N  \\nATOM     19  CA  CYS A   3      72.522  47.081   7.055  1.00 26.89           C  \\nANISOU   19  CA  CYS A   3     2826   4243   3149    267    153    220       C  \\nATOM     20  C   CYS A   3      73.237  48.308   6.528  1.00 33.69           C  \\nANISOU   20  C   CYS A   3     3660   5201   3938    216    122    198       C  \\nATOM     21  O   CYS A   3      74.030  48.927   7.244  1.00 39.81           O  \\nANISOU   21  O   CYS A   3     4407   6039   4681    230     97    225       O  \\nATOM     22  CB  CYS A   3      71.218  47.546   7.705  1.00 31.56           C  \\nANISOU   22  CB  CYS A   3     3455   4793   3742    238    138    260       C  \\nATOM     23  SG  CYS A   3      70.246  46.255   8.484  1.00 29.15           S  \\nANISOU   23  SG  CYS A   3     3178   4372   3527    283    184    308       S  \\nATOM     24  N   HIS A   4      72.950  48.671   5.279  1.00 23.00           N  \\nANISOU   24  N   HIS A   4     2315   3863   2561    156    124    151       N  \\nATOM     25  CA  HIS A   4      73.320  49.994   4.793  1.00 27.83           C  \\nANISOU   25  CA  HIS A   4     2915   4548   3111     95    100    152       C  \\nATOM     26  C   HIS A   4      72.627  51.054   5.666  1.00 31.22           C  \\nANISOU   26  C   HIS A   4     3371   4963   3527     67     59    197       C  \\nATOM     27  O   HIS A   4      71.455  50.903   6.009  1.00 39.81           O  \\nANISOU   27  O   HIS A   4     4496   5993   4637     69     53    211       O  \\nATOM     28  CB  HIS A   4      72.923  50.151   3.328  1.00 20.13           C  \\nANISOU   28  CB  HIS A   4     1956   3591   2103     47    110    109       C  \\nATOM     29  CG  HIS A   4      73.638  49.214   2.394  1.00 33.21           C  \\nANISOU   29  CG  HIS A   4     3584   5274   3759     75    151     49       C  \\nATOM     30  ND1 HIS A   4      75.003  49.242   2.210  1.00 33.39           N  \\nANISOU   30  ND1 HIS A   4     3554   5370   3763     92    176     42       N  \\nATOM     31  CD2 HIS A   4      73.174  48.231   1.586  1.00 23.47           C  \\nANISOU   31  CD2 HIS A   4     2365   4008   2544     89    173    -17       C  \\nATOM     32  CE1 HIS A   4      75.349  48.317   1.334  1.00 35.89           C  \\nANISOU   32  CE1 HIS A   4     3856   5698   4081    123    216    -22       C  \\nATOM     33  NE2 HIS A   4      74.258  47.686   0.942  1.00 35.86           N  \\nANISOU   33  NE2 HIS A   4     3896   5628   4100    122    212    -64       N  \\nATOM     34  N   ASN A   5      73.339  52.112   6.047  1.00 26.68           N  \\nANISOU   34  N   ASN A   5     2774   4440   2923     42     34    213       N  \\nATOM     35  CA  ASN A   5      72.739  53.125   6.926  1.00 34.14           C  \\nANISOU   35  CA  ASN A   5     3745   5368   3859     22     -5    241       C  \\nATOM     36  C   ASN A   5      72.878  54.585   6.481  1.00 34.73           C  \\nANISOU   36  C   ASN A   5     3823   5462   3910    -50    -27    244       C  \\nATOM     37  O   ASN A   5      72.683  55.497   7.280  1.00 37.63           O  \\nANISOU   37  O   ASN A   5     4202   5819   4277    -63    -61    253       O  \\nATOM     38  CB  ASN A   5      73.268  52.977   8.354  1.00 25.01           C  \\nANISOU   38  CB  ASN A   5     2566   4234   2702     78    -24    257       C  \\nATOM     39  CG  ASN A   5      74.733  53.325   8.470  1.00 39.97           C  \\nANISOU   39  CG  ASN A   5     4396   6204   4584     73    -37    239       C  \\nATOM     40  OD1 ASN A   5      75.518  53.099   7.541  1.00 39.30           O  \\nANISOU   40  OD1 ASN A   5     4275   6155   4504     55    -10    220       O  \\nATOM     41  ND2 ASN A   5      75.116  53.883   9.616  1.00 38.43           N  \\nANISOU   41  ND2 ASN A   5     4183   6046   4374     89    -78    239       N  \\nATOM     42  N   LYS A   6      73.233  54.794   5.217  1.00 40.38           N  \\nANISOU   42  N   LYS A   6     4530   6206   4608    -93     -5    236       N  \\nATOM     43  CA  LYS A   6      73.351  56.129   4.635  1.00 41.59           C  \\nANISOU   43  CA  LYS A   6     4691   6367   4744   -163    -13    257       C  \\nATOM     44  C   LYS A   6      72.689  56.093   3.270  1.00 31.47           C  \\nANISOU   44  C   LYS A   6     3442   5086   3428   -184      6    265       C  \\nATOM     45  O   LYS A   6      72.413  55.016   2.736  1.00 37.14           O  \\nANISOU   45  O   LYS A   6     4162   5812   4137   -151     25    235       O  \\nATOM     46  CB  LYS A   6      74.820  56.507   4.441  1.00 43.17           C  \\nANISOU   46  CB  LYS A   6     4828   6628   4946   -198      5    252       C  \\nATOM     47  CG  LYS A   6      75.703  56.308   5.656  1.00 42.18           C  \\nANISOU   47  CG  LYS A   6     4649   6533   4845   -167    -17    230       C  \\nATOM     48  CD  LYS A   6      75.450  57.358   6.714  1.00 32.74           C  \\nANISOU   48  CD  LYS A   6     3468   5305   3666   -188    -66    229       C  \\nATOM     49  CE  LYS A   6      76.394  57.151   7.892  1.00 57.53           C  \\nANISOU   49  CE  LYS A   6     6547   8498   6814   -152    -96    198       C  \\nATOM     50  NZ  LYS A   6      76.271  58.233   8.902  1.00 66.68           N  \\nANISOU   50  NZ  LYS A   6     7713   9638   7984   -176   -148    176       N  \\nATOM     51  N   LEU A   7      72.461  57.248   2.666  1.00 31.90           N  \\nANISOU   51  N   LEU A   7     3521   5134   3464   -235      0    302       N  \\nATOM     52  CA  LEU A   7      71.880  57.227   1.320  1.00 40.36           C  \\nANISOU   52  CA  LEU A   7     4623   6229   4484   -244     13    315       C  \\nATOM     53  C   LEU A   7      72.907  57.232   0.182  1.00 29.90           C  \\nANISOU   53  C   LEU A   7     3268   4982   3111   -271     63    323       C  \\nATOM     54  O   LEU A   7      72.543  57.240  -0.992  1.00 40.62           O  \\nANISOU   54  O   LEU A   7     4648   6379   4406   -275     76    335       O  \\nATOM     55  CB  LEU A   7      70.797  58.289   1.132  1.00 49.35           C  \\nANISOU   55  CB  LEU A   7     5813   7321   5615   -262    -20    361       C  \\nATOM     56  CG  LEU A   7      70.969  59.723   1.603  1.00 49.86           C  \\nANISOU   56  CG  LEU A   7     5893   7338   5714   -304    -35    408       C  \\nATOM     57  CD1 LEU A   7      70.749  59.814   3.106  1.00 73.38           C  \\nANISOU   57  CD1 LEU A   7     8870  10263   8748   -283    -68    379       C  \\nATOM     58  CD2 LEU A   7      72.340  60.256   1.194  1.00 31.68           C  \\nANISOU   58  CD2 LEU A   7     3553   5072   3411   -360      5    433       C  \\nATOM     59  N   VAL A   8      74.188  57.225   0.548  1.00 27.34           N  \\nANISOU   59  N   VAL A   8     2886   4690   2811   -287     89    316       N  \\nATOM     60  CA  VAL A   8      75.260  56.924  -0.388  1.00 35.76           C  \\nANISOU   60  CA  VAL A   8     3907   5842   3839   -298    147    309       C  \\nATOM     61  C   VAL A   8      75.449  55.401  -0.335  1.00 41.47           C  \\nANISOU   61  C   VAL A   8     4604   6590   4565   -230    161    238       C  \\nATOM     62  O   VAL A   8      74.969  54.758   0.604  1.00 36.62           O  \\nANISOU   62  O   VAL A   8     3999   5919   3994   -187    129    211       O  \\nATOM     63  CB  VAL A   8      76.562  57.675  -0.011  1.00 42.98           C  \\nANISOU   63  CB  VAL A   8     4757   6782   4793   -351    169    332       C  \\nATOM     64  CG1 VAL A   8      76.328  59.185  -0.015  1.00 34.60           C  \\nANISOU   64  CG1 VAL A   8     3726   5668   3752   -422    157    399       C  \\nATOM     65  CG2 VAL A   8      77.092  57.210   1.341  1.00 39.93           C  \\nANISOU   65  CG2 VAL A   8     4322   6382   4466   -318    138    288       C  \\nATOM     66  N   PRO A   9      76.118  54.808  -1.343  1.00 38.91           N  \\nANISOU   66  N   PRO A   9     4248   6343   4193   -216    214    209       N  \\nATOM     67  CA  PRO A   9      76.303  53.346  -1.332  1.00 37.97           C  \\nANISOU   67  CA  PRO A   9     4108   6232   4088   -146    230    133       C  \\nATOM     68  C   PRO A   9      77.274  52.822  -0.252  1.00 45.56           C  \\nANISOU   68  C   PRO A   9     5006   7188   5115   -108    232    116       C  \\nATOM     69  O   PRO A   9      77.885  53.622   0.455  1.00 34.52           O  \\nANISOU   69  O   PRO A   9     3572   5798   3745   -141    218    153       O  \\nATOM     70  CB  PRO A   9      76.889  53.047  -2.729  1.00 40.50           C  \\nANISOU   70  CB  PRO A   9     4405   6650   4332   -142    292    104       C  \\nATOM     71  CG  PRO A   9      76.612  54.253  -3.555  1.00 39.43           C  \\nANISOU   71  CG  PRO A   9     4302   6552   4128   -204    300    173       C  \\nATOM     72  CD  PRO A   9      76.614  55.415  -2.593  1.00 35.73           C  \\nANISOU   72  CD  PRO A   9     3836   6022   3719   -257    266    244       C  \\nATOM     73  N   PHE A  10      77.367  51.493  -0.130  1.00 32.23           N  \\nANISOU   73  N   PHE A  10     3306   5483   3455    -35    246     59       N  \\nATOM     74  CA  PHE A  10      78.455  50.785   0.568  1.00 36.03           C  \\nANISOU   74  CA  PHE A  10     3720   5984   3984     25    260     40       C  \\nATOM     75  C   PHE A  10      78.520  50.847   2.093  1.00 38.05           C  \\nANISOU   75  C   PHE A  10     3965   6197   4296     51    213     74       C  \\nATOM     76  O   PHE A  10      78.621  49.808   2.754  1.00 39.95           O  \\nANISOU   76  O   PHE A  10     4198   6402   4580    130    211     60       O  \\nATOM     77  CB  PHE A  10      79.825  51.160   0.004  1.00 44.76           C  \\nANISOU   77  CB  PHE A  10     4743   7197   5065      4    308     39       C  \\nATOM     78  CG  PHE A  10      80.953  50.366   0.602  1.00 43.56           C  \\nANISOU   78  CG  PHE A  10     4511   7079   4960     77    322     12       C  \\nATOM     79  CD1 PHE A  10      81.148  49.035   0.244  1.00 50.97           C  \\nANISOU   79  CD1 PHE A  10     5441   8010   5916    163    358    -48       C  \\nATOM     80  CD2 PHE A  10      81.816  50.940   1.517  1.00 39.34           C  \\nANISOU   80  CD2 PHE A  10     3907   6584   4458     65    296     41       C  \\nATOM     81  CE1 PHE A  10      82.185  48.287   0.790  1.00 45.81           C  \\nANISOU   81  CE1 PHE A  10     4713   7385   5309    245    370    -66       C  \\nATOM     82  CE2 PHE A  10      82.856  50.199   2.067  1.00 50.28           C  \\nANISOU   82  CE2 PHE A  10     5209   8013   5881    143    302     19       C  \\nATOM     83  CZ  PHE A  10      83.040  48.869   1.700  1.00 48.60           C  \\nANISOU   83  CZ  PHE A  10     4991   7789   5684    238    340    -29       C  \\nATOM     84  N   LEU A  11      78.535  52.060   2.634  1.00 26.30           N  \\nANISOU   84  N   LEU A  11     2475   4716   2804     -9    178    117       N  \\nATOM     85  CA  LEU A  11      78.553  52.275   4.080  1.00 37.67           C  \\nANISOU   85  CA  LEU A  11     3907   6131   4276     13    126    139       C  \\nATOM     86  C   LEU A  11      77.528  51.419   4.839  1.00 39.89           C  \\nANISOU   86  C   LEU A  11     4247   6329   4581     77    107    147       C  \\nATOM     87  O   LEU A  11      76.385  51.250   4.401  1.00 32.57           O  \\nANISOU   87  O   LEU A  11     3383   5341   3650     63    110    146       O  \\nATOM     88  CB  LEU A  11      78.311  53.753   4.372  1.00 32.16           C  \\nANISOU   88  CB  LEU A  11     3224   5425   3570    -69     90    169       C  \\nATOM     89  CG  LEU A  11      79.536  54.619   4.673  1.00 51.12           C  \\nANISOU   89  CG  LEU A  11     5543   7893   5987   -117     81    167       C  \\nATOM     90  CD1 LEU A  11      80.827  54.033   4.102  1.00 32.85           C  \\nANISOU   90  CD1 LEU A  11     3139   5668   3676    -95    129    142       C  \\nATOM     91  CD2 LEU A  11      79.302  56.041   4.171  1.00 42.87           C  \\nANISOU   91  CD2 LEU A  11     4521   6828   4939   -220     81    196       C  \\nATOM     92  N   SER A  12      77.943  50.871   5.972  1.00 27.07           N  \\nANISOU   92  N   SER A  12     2596   4708   2981    148     87    159       N  \\nATOM     93  CA  SER A  12      77.050  50.040   6.767  1.00 30.77           C  \\nANISOU   93  CA  SER A  12     3116   5099   3475    210     81    184       C  \\nATOM     94  C   SER A  12      77.434  50.038   8.234  1.00 34.34           C  \\nANISOU   94  C   SER A  12     3546   5578   3924    270     42    219       C  \\nATOM     95  O   SER A  12      78.502  50.511   8.621  1.00 38.79           O  \\nANISOU   95  O   SER A  12     4043   6223   4471    273     16    210       O  \\nATOM     96  CB  SER A  12      77.037  48.603   6.260  1.00 25.87           C  \\nANISOU   96  CB  SER A  12     2502   4433   2896    274    128    162       C  \\nATOM     97  OG  SER A  12      78.293  47.988   6.475  1.00 31.62           O  \\nANISOU   97  OG  SER A  12     3162   5213   3638    345    141    155       O  \\nATOM     98  N   LYS A  13      76.534  49.497   9.040  1.00 24.30           N  \\nANISOU   98  N   LYS A  13     2326   4241   2665    318     41    259       N  \\nATOM     99  CA  LYS A  13      76.757  49.330  10.463  1.00 32.10           C  \\nANISOU   99  CA  LYS A  13     3306   5257   3635    393     11    303       C  \\nATOM    100  C   LYS A  13      76.226  47.969  10.849  1.00 34.57           C  \\nANISOU  100  C   LYS A  13     3656   5490   3989    477     51    352       C  \\nATOM    101  O   LYS A  13      75.394  47.385  10.154  1.00 39.29           O  \\nANISOU  101  O   LYS A  13     4295   5998   4634    455     93    344       O  \\nATOM    102  CB  LYS A  13      76.017  50.406  11.261  1.00 20.10           C  \\nANISOU  102  CB  LYS A  13     1821   3743   2074    355    -31    316       C  \\nATOM    103  CG  LYS A  13      74.488  50.275  11.217  1.00 38.96           C  \\nANISOU  103  CG  LYS A  13     4284   6039   4481    334     -7    341       C  \\nATOM    104  CD  LYS A  13      73.786  51.339  12.086  1.00 51.84           C  \\nANISOU  104  CD  LYS A  13     5946   7683   6070    311    -45    349       C  \\nATOM    105  CE  LYS A  13      74.214  51.237  13.552  1.00 61.13           C  \\nANISOU  105  CE  LYS A  13     7107   8923   7197    395    -74    380       C  \\nATOM    106  NZ  LYS A  13      73.520  52.226  14.425  1.00 63.57           N  \\nANISOU  106  NZ  LYS A  13     7446   9249   7458    382   -107    374       N  \\nATOM    107  N   THR A  14      76.719  47.452  11.956  1.00 27.82           N  \\nANISOU  107  N   THR A  14     2783   4668   3119    574     39    404       N  \\nATOM    108  CA  THR A  14      76.116  46.278  12.546  1.00 25.89           C  \\nANISOU  108  CA  THR A  14     2584   4340   2914    654     81    476       C  \\nATOM    109  C   THR A  14      74.960  46.746  13.430  1.00 34.21           C  \\nANISOU  109  C   THR A  14     3691   5373   3933    639     74    523       C  \\nATOM    110  O   THR A  14      75.137  47.628  14.286  1.00 30.42           O  \\nANISOU  110  O   THR A  14     3201   4981   3378    644     23    527       O  \\nATOM    111  CB  THR A  14      77.110  45.513  13.445  1.00 44.92           C  \\nANISOU  111  CB  THR A  14     4956   6800   5312    783     73    533       C  \\nATOM    112  OG1 THR A  14      78.187  44.984  12.659  1.00 27.13           O  \\nANISOU  112  OG1 THR A  14     2645   4565   3098    813     87    489       O  \\nATOM    113  CG2 THR A  14      76.392  44.368  14.184  1.00 33.14           C  \\nANISOU  113  CG2 THR A  14     3520   5211   3860    867    125    632       C  \\nATOM    114  N   CYS A  15      73.789  46.152  13.223  1.00 28.76           N  \\nANISOU  114  N   CYS A  15     3054   4572   3301    619    125    550       N  \\nATOM    115  CA  CYS A  15      72.599  46.481  14.005  1.00 38.17           C  \\nANISOU  115  CA  CYS A  15     4292   5740   4472    607    133    598       C  \\nATOM    116  C   CYS A  15      72.734  46.151  15.489  1.00 34.51           C  \\nANISOU  116  C   CYS A  15     3837   5320   3954    711    136    692       C  \\nATOM    117  O   CYS A  15      73.257  45.088  15.849  1.00 27.73           O  \\nANISOU  117  O   CYS A  15     2974   4441   3122    803    165    756       O  \\nATOM    118  CB  CYS A  15      71.393  45.728  13.454  1.00 41.13           C  \\nANISOU  118  CB  CYS A  15     4704   5986   4939    568    194    608       C  \\nATOM    119  SG  CYS A  15      71.085  46.022  11.724  1.00 34.82           S  \\nANISOU  119  SG  CYS A  15     3898   5147   4185    458    188    499       S  \\nATOM    120  N   PRO A  16      72.226  47.056  16.346  1.00 32.96           N  \\nANISOU  120  N   PRO A  16     3657   5186   3679    705    107    703       N  \\nATOM    121  CA  PRO A  16      72.130  46.844  17.796  1.00 23.81           C  \\nANISOU  121  CA  PRO A  16     2516   4084   2447    803    113    793       C  \\nATOM    122  C   PRO A  16      71.205  45.670  18.117  1.00 36.71           C  \\nANISOU  122  C   PRO A  16     4193   5610   4146    842    203    899       C  \\nATOM    123  O   PRO A  16      70.332  45.334  17.307  1.00 27.82           O  \\nANISOU  123  O   PRO A  16     3084   4370   3117    769    250    882       O  \\nATOM    124  CB  PRO A  16      71.472  48.143  18.311  1.00 28.54           C  \\nANISOU  124  CB  PRO A  16     3130   4746   2969    758     76    752       C  \\nATOM    125  CG  PRO A  16      71.512  49.117  17.162  1.00 38.79           C  \\nANISOU  125  CG  PRO A  16     4411   6029   4299    645     37    644       C  \\nATOM    126  CD  PRO A  16      71.560  48.305  15.917  1.00 27.72           C  \\nANISOU  126  CD  PRO A  16     3003   4532   2998    605     76    632       C  \\nATOM    127  N   GLU A  17      71.391  45.056  19.283  1.00 32.45           N  \\nANISOU  127  N   GLU A  17     3667   5107   3555    956    226   1009       N  \\nATOM    128  CA  GLU A  17      70.459  44.035  19.760  1.00 47.44           C  \\nANISOU  128  CA  GLU A  17     5607   6905   5511    992    322   1130       C  \\nATOM    129  C   GLU A  17      69.031  44.536  19.673  1.00 44.11           C  \\nANISOU  129  C   GLU A  17     5209   6439   5113    904    358   1114       C  \\nATOM    130  O   GLU A  17      68.741  45.689  20.019  1.00 40.77           O  \\nANISOU  130  O   GLU A  17     4784   6107   4600    877    312   1062       O  \\nATOM    131  CB  GLU A  17      70.761  43.649  21.206  1.00 30.45           C  \\nANISOU  131  CB  GLU A  17     3473   4839   3257   1129    336   1259       C  \\nATOM    132  CG  GLU A  17      72.147  43.085  21.379  1.00 53.32           C  \\nANISOU  132  CG  GLU A  17     6341   7788   6130   1236    298   1287       C  \\nATOM    133  CD  GLU A  17      72.422  42.619  22.797  1.00 59.42           C  \\nANISOU  133  CD  GLU A  17     7133   8650   6795   1386    311   1430       C  \\nATOM    134  OE1 GLU A  17      73.597  42.645  23.199  1.00 71.39           O  \\nANISOU  134  OE1 GLU A  17     8612  10283   8230   1480    243   1429       O  \\nATOM    135  OE2 GLU A  17      71.484  42.228  23.509  1.00 49.36           O  \\nANISOU  135  OE2 GLU A  17     5905   7340   5511   1414    390   1545       O  \\nATOM    136  N   GLY A  18      68.139  43.671  19.209  1.00 43.03           N  \\nANISOU  136  N   GLY A  18     5087   6159   5103    860    438   1151       N  \\nATOM    137  CA  GLY A  18      66.740  44.038  19.111  1.00 41.84           C  \\nANISOU  137  CA  GLY A  18     4944   5965   4988    779    476   1140       C  \\nATOM    138  C   GLY A  18      66.295  44.479  17.726  1.00 42.56           C  \\nANISOU  138  C   GLY A  18     5015   5999   5158    657    445   1013       C  \\nATOM    139  O   GLY A  18      65.120  44.330  17.384  1.00 42.25           O  \\nANISOU  139  O   GLY A  18     4972   5882   5198    589    490   1007       O  \\nATOM    140  N   LYS A  19      67.216  45.026  16.932  1.00 42.12           N  \\nANISOU  140  N   LYS A  19     4940   5988   5074    632    371    915       N  \\nATOM    141  CA  LYS A  19      66.902  45.423  15.556  1.00 37.08           C  \\nANISOU  141  CA  LYS A  19     4287   5309   4495    529    341    803       C  \\nATOM    142  C   LYS A  19      67.416  44.406  14.542  1.00 37.63           C  \\nANISOU  142  C   LYS A  19     4346   5289   4662    517    360    767       C  \\nATOM    143  O   LYS A  19      68.577  44.441  14.148  1.00 51.95           O  \\nANISOU  143  O   LYS A  19     6144   7146   6448    542    323    727       O  \\nATOM    144  CB  LYS A  19      67.470  46.807  15.247  1.00 32.35           C  \\nANISOU  144  CB  LYS A  19     3674   4813   3803    496    257    719       C  \\nATOM    145  CG  LYS A  19      67.120  47.860  16.291  1.00 24.74           C  \\nANISOU  145  CG  LYS A  19     2722   3939   2741    517    231    736       C  \\nATOM    146  CD  LYS A  19      67.587  49.258  15.880  1.00 33.80           C  \\nANISOU  146  CD  LYS A  19     3857   5158   3827    470    151    645       C  \\nATOM    147  CE  LYS A  19      67.132  50.311  16.892  1.00 42.58           C  \\nANISOU  147  CE  LYS A  19     4982   6342   4854    489    128    644       C  \\nATOM    148  NZ  LYS A  19      67.356  51.706  16.407  1.00 37.28           N  \\nANISOU  148  NZ  LYS A  19     4305   5706   4153    429     60    554       N  \\nATOM    149  N   ASN A  20      66.543  43.502  14.118  1.00 38.77           N  \\nANISOU  149  N   ASN A  20     4494   5311   4925    478    419    772       N  \\nATOM    150  CA  ASN A  20      66.929  42.444  13.197  1.00 36.11           C  \\nANISOU  150  CA  ASN A  20     4152   4876   4694    470    443    726       C  \\nATOM    151  C   ASN A  20      66.331  42.613  11.800  1.00 44.74           C  \\nANISOU  151  C   ASN A  20     5227   5932   5839    369    419    602       C  \\nATOM    152  O   ASN A  20      66.145  41.626  11.073  1.00 34.02           O  \\nANISOU  152  O   ASN A  20     3865   4469   4593    344    453    555       O  \\nATOM    153  CB  ASN A  20      66.512  41.085  13.754  1.00 45.81           C  \\nANISOU  153  CB  ASN A  20     5396   5971   6039    509    532    820       C  \\nATOM    154  CG  ASN A  20      67.099  40.810  15.110  1.00 48.77           C  \\nANISOU  154  CG  ASN A  20     5792   6385   6354    624    559    957       C  \\nATOM    155  OD1 ASN A  20      68.322  40.818  15.287  1.00 58.37           O  \\nANISOU  155  OD1 ASN A  20     7004   7667   7508    702    524    965       O  \\nATOM    156  ND2 ASN A  20      66.231  40.575  16.089  1.00 55.89           N  \\nANISOU  156  ND2 ASN A  20     6711   7257   7268    640    622   1068       N  \\nATOM    157  N   LEU A  21      66.021  43.855  11.436  1.00 34.22           N  \\nANISOU  157  N   LEU A  21     3886   4688   4426    314    361    549       N  \\nATOM    158  CA  LEU A  21      65.571  44.177  10.084  1.00 40.39           C  \\nANISOU  158  CA  LEU A  21     4652   5468   5225    232    325    438       C  \\nATOM    159  C   LEU A  21      66.333  45.369   9.531  1.00 42.11           C  \\nANISOU  159  C   LEU A  21     4866   5799   5334    217    258    387       C  \\nATOM    160  O   LEU A  21      66.586  46.339  10.249  1.00 38.23           O  \\nANISOU  160  O   LEU A  21     4381   5386   4760    237    228    427       O  \\nATOM    161  CB  LEU A  21      64.082  44.519  10.064  1.00 34.00           C  \\nANISOU  161  CB  LEU A  21     3832   4637   4449    168    328    431       C  \\nATOM    162  CG  LEU A  21      63.075  43.393  10.283  1.00 51.02           C  \\nANISOU  162  CG  LEU A  21     5975   6670   6739    146    397    457       C  \\nATOM    163  CD1 LEU A  21      61.672  43.991  10.350  1.00 33.60           C  \\nANISOU  163  CD1 LEU A  21     3743   4478   4544     88    390    451       C  \\nATOM    164  CD2 LEU A  21      63.199  42.313   9.189  1.00 37.76           C  \\nANISOU  164  CD2 LEU A  21     4284   4898   5163    114    409    365       C  \\nATOM    165  N   CYS A  22      66.689  45.290   8.252  1.00 29.68           N  \\nANISOU  165  N   CYS A  22     3281   4233   3762    182    237    298       N  \\nATOM    166  CA  CYS A  22      67.186  46.443   7.527  1.00 19.20           C  \\nANISOU  166  CA  CYS A  22     1948   3004   2341    151    183    253       C  \\nATOM    167  C   CYS A  22      65.973  47.164   6.951  1.00 34.70           C  \\nANISOU  167  C   CYS A  22     3913   4976   4295     85    151    221       C  \\nATOM    168  O   CYS A  22      64.951  46.543   6.641  1.00 24.20           O  \\nANISOU  168  O   CYS A  22     2575   3583   3036     55    167    191       O  \\nATOM    169  CB  CYS A  22      68.139  46.008   6.397  1.00 19.50           C  \\nANISOU  169  CB  CYS A  22     1973   3062   2375    152    184    180       C  \\nATOM    170  SG  CYS A  22      69.615  45.092   6.930  1.00 29.65           S  \\nANISOU  170  SG  CYS A  22     3244   4341   3682    241    220    208       S  \\nATOM    171  N   TYR A  23      66.069  48.476   6.811  1.00 36.88           N  \\nANISOU  171  N   TYR A  23     4196   5327   4490     63    107    225       N  \\nATOM    172  CA  TYR A  23      64.989  49.218   6.170  1.00 41.02           C  \\nANISOU  172  CA  TYR A  23     4720   5866   4998     14     71    199       C  \\nATOM    173  C   TYR A  23      65.551  50.199   5.140  1.00 39.04           C  \\nANISOU  173  C   TYR A  23     4475   5689   4667    -14     31    170       C  \\nATOM    174  O   TYR A  23      66.693  50.641   5.256  1.00 33.21           O  \\nANISOU  174  O   TYR A  23     3739   4995   3884     -3     29    187       O  \\nATOM    175  CB  TYR A  23      64.111  49.945   7.211  1.00 22.36           C  \\nANISOU  175  CB  TYR A  23     2365   3499   2633     21     65    254       C  \\nATOM    176  CG  TYR A  23      64.723  51.214   7.755  1.00 34.22           C  \\nANISOU  176  CG  TYR A  23     3883   5058   4061     33     35    287       C  \\nATOM    177  CD1 TYR A  23      65.565  51.175   8.864  1.00 35.21           C  \\nANISOU  177  CD1 TYR A  23     4013   5200   4166     79     48    327       C  \\nATOM    178  CD2 TYR A  23      64.473  52.452   7.158  1.00 27.40           C  \\nANISOU  178  CD2 TYR A  23     3030   4230   3152      1    -10    274       C  \\nATOM    179  CE1 TYR A  23      66.136  52.327   9.368  1.00 39.71           C  \\nANISOU  179  CE1 TYR A  23     4592   5820   4676     84     14    337       C  \\nATOM    180  CE2 TYR A  23      65.052  53.615   7.655  1.00 40.83           C  \\nANISOU  180  CE2 TYR A  23     4747   5964   4805      5    -35    296       C  \\nATOM    181  CZ  TYR A  23      65.883  53.543   8.761  1.00 43.79           C  \\nANISOU  181  CZ  TYR A  23     5119   6354   5165     42    -24    318       C  \\nATOM    182  OH  TYR A  23      66.456  54.685   9.273  1.00 33.01           O  \\nANISOU  182  OH  TYR A  23     3763   5020   3760     40    -55    321       O  \\nATOM    183  N   LYS A  24      64.750  50.510   4.126  1.00 38.59           N  \\nANISOU  183  N   LYS A  24     4418   5651   4595    -51      1    131       N  \\nATOM    184  CA  LYS A  24      65.086  51.538   3.144  1.00 39.22           C  \\nANISOU  184  CA  LYS A  24     4508   5801   4592    -75    -33    125       C  \\nATOM    185  C   LYS A  24      63.851  52.367   2.827  1.00 43.17           C  \\nANISOU  185  C   LYS A  24     5014   6312   5077    -93    -76    134       C  \\nATOM    186  O   LYS A  24      62.806  51.831   2.430  1.00 38.18           O  \\nANISOU  186  O   LYS A  24     4362   5664   4479   -104    -88     92       O  \\nATOM    187  CB  LYS A  24      65.628  50.937   1.839  1.00 28.26           C  \\nANISOU  187  CB  LYS A  24     3112   4454   3172    -84    -26     60       C  \\nATOM    188  CG  LYS A  24      65.805  51.988   0.734  1.00 28.04           C  \\nANISOU  188  CG  LYS A  24     3097   4506   3049   -107    -55     67       C  \\nATOM    189  CD  LYS A  24      66.568  51.463  -0.492  1.00 26.01           C  \\nANISOU  189  CD  LYS A  24     2832   4312   2737   -107    -37      8       C  \\nATOM    190  CE  LYS A  24      65.763  50.417  -1.256  1.00 29.62           C  \\nANISOU  190  CE  LYS A  24     3277   4764   3215   -108    -49    -87       C  \\nATOM    191  NZ  LYS A  24      66.454  49.950  -2.469  1.00 23.86           N  \\nANISOU  191  NZ  LYS A  24     2541   4105   2419   -101    -33   -157       N  \\nATOM    192  N   MET A  25      63.970  53.676   3.008  1.00 26.91           N  \\nANISOU  192  N   MET A  25     2975   4274   2974    -96    -99    185       N  \\nATOM    193  CA  MET A  25      62.890  54.571   2.643  1.00 29.93           C  \\nANISOU  193  CA  MET A  25     3365   4668   3339   -102   -141    201       C  \\nATOM    194  C   MET A  25      63.195  55.220   1.319  1.00 35.39           C  \\nANISOU  194  C   MET A  25     4073   5421   3952   -117   -166    205       C  \\nATOM    195  O   MET A  25      64.326  55.655   1.085  1.00 31.93           O  \\nANISOU  195  O   MET A  25     3651   5009   3474   -129   -149    230       O  \\nATOM    196  CB  MET A  25      62.694  55.652   3.688  1.00 24.89           C  \\nANISOU  196  CB  MET A  25     2745   4001   2711    -87   -150    254       C  \\nATOM    197  CG  MET A  25      62.223  55.122   5.027  1.00 41.82           C  \\nANISOU  197  CG  MET A  25     4875   6100   4914    -62   -124    259       C  \\nATOM    198  SD  MET A  25      61.769  56.459   6.146  1.00 57.53           S  \\nANISOU  198  SD  MET A  25     6886   8071   6904    -36   -139    300       S  \\nATOM    199  CE  MET A  25      61.411  55.518   7.633  1.00 43.19           C  \\nANISOU  199  CE  MET A  25     5050   6227   5134     -2    -91    309       C  \\nATOM    200  N   THR A  26      62.176  55.283   0.465  1.00 34.22           N  \\nANISOU  200  N   THR A  26     3916   5305   3782   -116   -205    185       N  \\nATOM    201  CA  THR A  26      62.264  55.979  -0.811  1.00 34.35           C  \\nANISOU  201  CA  THR A  26     3951   5391   3708   -118   -234    204       C  \\nATOM    202  C   THR A  26      61.033  56.853  -0.978  1.00 37.37           C  \\nANISOU  202  C   THR A  26     4336   5779   4083    -97   -286    238       C  \\nATOM    203  O   THR A  26      59.988  56.581  -0.370  1.00 29.32           O  \\nANISOU  203  O   THR A  26     3287   4727   3128    -86   -302    215       O  \\nATOM    204  CB  THR A  26      62.297  54.985  -1.987  1.00 30.61           C  \\nANISOU  204  CB  THR A  26     3458   4984   3187   -123   -239    125       C  \\nATOM    205  OG1 THR A  26      61.191  54.078  -1.880  1.00 29.13           O  \\nANISOU  205  OG1 THR A  26     3230   4775   3061   -122   -262     52       O  \\nATOM    206  CG2 THR A  26      63.591  54.184  -1.968  1.00 22.01           C  \\nANISOU  206  CG2 THR A  26     2367   3896   2100   -133   -185     92       C  \\nATOM    207  N   LEU A  27      61.146  57.903  -1.791  1.00 25.60           N  \\nANISOU  207  N   LEU A  27     2878   4331   2520    -88   -308    299       N  \\nATOM    208  CA  LEU A  27      59.953  58.608  -2.249  1.00 41.50           C  \\nANISOU  208  CA  LEU A  27     4889   6368   4510    -54   -366    328       C  \\nATOM    209  C   LEU A  27      59.214  57.708  -3.236  1.00 45.35           C  \\nANISOU  209  C   LEU A  27     5336   6938   4956    -46   -408    249       C  \\nATOM    210  O   LEU A  27      59.832  57.146  -4.148  1.00 27.98           O  \\nANISOU  210  O   LEU A  27     3139   4806   2686    -58   -398    209       O  \\nATOM    211  CB  LEU A  27      60.326  59.913  -2.943  1.00 28.98           C  \\nANISOU  211  CB  LEU A  27     3354   4803   2855    -41   -374    427       C  \\nATOM    212  CG  LEU A  27      60.963  60.998  -2.081  1.00 28.57           C  \\nANISOU  212  CG  LEU A  27     3341   4662   2852    -53   -343    500       C  \\nATOM    213  CD1 LEU A  27      61.117  62.244  -2.928  1.00 24.57           C  \\nANISOU  213  CD1 LEU A  27     2882   4167   2287    -40   -352    603       C  \\nATOM    214  CD2 LEU A  27      60.108  61.274  -0.862  1.00 19.89           C  \\nANISOU  214  CD2 LEU A  27     2228   3485   1842    -30   -358    489       C  \\nATOM    215  N   MET A  28      57.902  57.570  -3.062  1.00 40.64           N  \\nANISOU  215  N   MET A  28     4695   6342   4404    -26   -453    216       N  \\nATOM    216  CA  MET A  28      57.122  56.688  -3.934  1.00 43.96           C  \\nANISOU  216  CA  MET A  28     5063   6839   4800    -26   -502    122       C  \\nATOM    217  C   MET A  28      57.336  56.995  -5.413  1.00 43.79           C  \\nANISOU  217  C   MET A  28     5063   6937   4638     -2   -542    130       C  \\nATOM    218  O   MET A  28      57.349  56.086  -6.249  1.00 40.73           O  \\nANISOU  218  O   MET A  28     4650   6623   4202    -13   -560     35       O  \\nATOM    219  CB  MET A  28      55.631  56.712  -3.583  1.00 40.30           C  \\nANISOU  219  CB  MET A  28     4537   6371   4404     -6   -551     97       C  \\nATOM    220  CG  MET A  28      55.298  55.906  -2.324  1.00 49.17           C  \\nANISOU  220  CG  MET A  28     5618   7401   5661    -38   -505     56       C  \\nATOM    221  SD  MET A  28      53.537  55.596  -2.096  1.00105.03           S  \\nANISOU  221  SD  MET A  28    12593  14488  12823    -31   -553      0       S  \\nATOM    222  CE  MET A  28      53.537  54.390  -0.763  1.00 35.08           C  \\nANISOU  222  CE  MET A  28     3699   5520   4108    -83   -469    -39       C  \\nATOM    223  N   LYS A  29      57.545  58.270  -5.725  1.00 38.25           N  \\nANISOU  223  N   LYS A  29     4412   6251   3869     31   -550    246       N  \\nATOM    224  CA  LYS A  29      57.769  58.684  -7.112  1.00 57.30           C  \\nANISOU  224  CA  LYS A  29     6854   8782   6135     62   -578    283       C  \\nATOM    225  C   LYS A  29      59.210  58.506  -7.603  1.00 55.13           C  \\nANISOU  225  C   LYS A  29     6621   8537   5788     33   -512    298       C  \\nATOM    226  O   LYS A  29      59.459  58.558  -8.802  1.00 70.00           O  \\nANISOU  226  O   LYS A  29     8522  10537   7539     56   -524    307       O  \\nATOM    227  CB  LYS A  29      57.290  60.124  -7.325  1.00 61.73           C  \\nANISOU  227  CB  LYS A  29     7451   9344   6658    117   -613    414       C  \\nATOM    228  CG  LYS A  29      55.768  60.250  -7.330  1.00 67.07           C  \\nANISOU  228  CG  LYS A  29     8072  10050   7361    167   -696    390       C  \\nATOM    229  CD  LYS A  29      55.310  61.693  -7.432  1.00 83.95           C  \\nANISOU  229  CD  LYS A  29    10248  12171   9479    234   -726    525       C  \\nATOM    230  CE  LYS A  29      53.803  61.771  -7.657  1.00 92.77           C  \\nANISOU  230  CE  LYS A  29    11299  13349  10601    297   -819    496       C  \\nATOM    231  NZ  LYS A  29      53.292  63.172  -7.546  1.00 95.08           N  \\nANISOU  231  NZ  LYS A  29    11624  13597  10903    372   -843    626       N  \\nATOM    232  N   MET A  30      60.147  58.288  -6.680  1.00 50.55           N  \\nANISOU  232  N   MET A  30     6053   7865   5290    -10   -442    300       N  \\nATOM    233  CA  MET A  30      61.554  58.076  -7.030  1.00 41.22           C  \\nANISOU  233  CA  MET A  30     4895   6708   4057    -39   -375    308       C  \\nATOM    234  C   MET A  30      62.118  56.854  -6.320  1.00 30.24           C  \\nANISOU  234  C   MET A  30     3474   5265   2751    -73   -331    209       C  \\nATOM    235  O   MET A  30      62.831  57.002  -5.333  1.00 28.86           O  \\nANISOU  235  O   MET A  30     3307   5006   2652    -97   -284    242       O  \\nATOM    236  CB  MET A  30      62.381  59.289  -6.614  1.00 42.92           C  \\nANISOU  236  CB  MET A  30     5157   6861   4289    -55   -328    436       C  \\nATOM    237  CG  MET A  30      61.814  60.615  -7.055  1.00 38.63           C  \\nANISOU  237  CG  MET A  30     4652   6325   3700    -19   -362    554       C  \\nATOM    238  SD  MET A  30      62.377  61.021  -8.712  1.00217.45           S  \\nANISOU  238  SD  MET A  30    27336  29114  26171      3   -344    631       S  \\nATOM    239  CE  MET A  30      64.133  60.809  -8.464  1.00130.57           C  \\nANISOU  239  CE  MET A  30    16336  18087  15188    -63   -239    638       C  \\nATOM    240  N   PRO A  31      61.790  55.646  -6.806  1.00 34.16           N  \\nANISOU  240  N   PRO A  31     3934   5807   3237    -71   -350     86       N  \\nATOM    241  CA  PRO A  31      62.223  54.408  -6.139  1.00 40.20           C  \\nANISOU  241  CA  PRO A  31     4672   6507   4097    -96   -309     -6       C  \\nATOM    242  C   PRO A  31      63.738  54.163  -6.150  1.00 40.22           C  \\nANISOU  242  C   PRO A  31     4688   6513   4079   -108   -235      2       C  \\nATOM    243  O   PRO A  31      64.225  53.363  -5.345  1.00 51.64           O  \\nANISOU  243  O   PRO A  31     6119   7887   5617   -120   -196    -39       O  \\nATOM    244  CB  PRO A  31      61.494  53.310  -6.934  1.00 42.24           C  \\nANISOU  244  CB  PRO A  31     4891   6821   4338    -91   -351   -143       C  \\nATOM    245  CG  PRO A  31      61.179  53.921  -8.240  1.00 34.64           C  \\nANISOU  245  CG  PRO A  31     3942   5994   3226    -60   -401   -128       C  \\nATOM    246  CD  PRO A  31      60.917  55.370  -7.962  1.00 29.36           C  \\nANISOU  246  CD  PRO A  31     3306   5311   2538    -43   -417     20       C  \\nATOM    247  N   LYS A  32      64.462  54.856  -7.026  1.00 42.97           N  \\nANISOU  247  N   LYS A  32     5064   6949   4314   -102   -214     62       N  \\nATOM    248  CA  LYS A  32      65.900  54.646  -7.208  1.00 34.90           C  \\nANISOU  248  CA  LYS A  32     4042   5955   3263   -113   -141     66       C  \\nATOM    249  C   LYS A  32      66.771  55.355  -6.167  1.00 48.78           C  \\nANISOU  249  C   LYS A  32     5807   7634   5092   -140    -96    158       C  \\nATOM    250  O   LYS A  32      67.965  55.075  -6.063  1.00 53.16           O  \\nANISOU  250  O   LYS A  32     6346   8200   5653   -151    -38    152       O  \\nATOM    251  CB  LYS A  32      66.315  55.090  -8.613  1.00 38.20           C  \\nANISOU  251  CB  LYS A  32     4481   6511   3524    -97   -126     97       C  \\nATOM    252  CG  LYS A  32      65.743  54.236  -9.734  1.00 52.65           C  \\nANISOU  252  CG  LYS A  32     6297   8445   5261    -65   -163    -21       C  \\nATOM    253  CD  LYS A  32      66.536  52.951  -9.891  1.00 50.72           C  \\nANISOU  253  CD  LYS A  32     6025   8213   5033    -61   -115   -147       C  \\nATOM    254  CE  LYS A  32      65.981  52.087 -10.993  1.00 62.81           C  \\nANISOU  254  CE  LYS A  32     7544   9844   6478    -31   -156   -287       C  \\nATOM    255  NZ  LYS A  32      65.307  50.901 -10.426  1.00 64.56           N  \\nANISOU  255  NZ  LYS A  32     7732   9967   6831    -42   -187   -420       N  \\nATOM    256  N   ILE A  33      66.175  56.267  -5.402  1.00 44.71           N  \\nANISOU  256  N   ILE A  33     5310   7047   4631   -148   -127    232       N  \\nATOM    257  CA  ILE A  33      66.924  57.072  -4.444  1.00 34.35           C  \\nANISOU  257  CA  ILE A  33     4005   5665   3382   -176    -96    308       C  \\nATOM    258  C   ILE A  33      66.526  56.782  -3.011  1.00 30.75           C  \\nANISOU  258  C   ILE A  33     3536   5108   3040   -174   -112    284       C  \\nATOM    259  O   ILE A  33      65.434  57.141  -2.591  1.00 40.82           O  \\nANISOU  259  O   ILE A  33     4822   6339   4350   -161   -155    298       O  \\nATOM    260  CB  ILE A  33      66.723  58.574  -4.688  1.00 34.96           C  \\nANISOU  260  CB  ILE A  33     4121   5733   3430   -186   -109    422       C  \\nATOM    261  CG1 ILE A  33      67.162  58.947  -6.098  1.00 38.85           C  \\nANISOU  261  CG1 ILE A  33     4631   6332   3800   -185    -83    472       C  \\nATOM    262  CG2 ILE A  33      67.505  59.389  -3.666  1.00 41.58           C  \\nANISOU  262  CG2 ILE A  33     4961   6490   4347   -223    -81    478       C  \\nATOM    263  CD1 ILE A  33      67.261  60.425  -6.305  1.00 38.46           C  \\nANISOU  263  CD1 ILE A  33     4621   6256   3736   -201    -74    605       C  \\nATOM    264  N   PRO A  34      67.423  56.138  -2.250  1.00 32.58           N  \\nANISOU  264  N   PRO A  34     3742   5311   3326   -179    -75    253       N  \\nATOM    265  CA  PRO A  34      67.173  55.915  -0.825  1.00 31.26           C  \\nANISOU  265  CA  PRO A  34     3566   5060   3251   -170    -83    246       C  \\nATOM    266  C   PRO A  34      67.280  57.263  -0.133  1.00 36.38           C  \\nANISOU  266  C   PRO A  34     4236   5667   3922   -189    -94    318       C  \\nATOM    267  O   PRO A  34      68.229  57.999  -0.436  1.00 30.61           O  \\nANISOU  267  O   PRO A  34     3507   4958   3166   -219    -71    361       O  \\nATOM    268  CB  PRO A  34      68.350  55.021  -0.385  1.00 25.17           C  \\nANISOU  268  CB  PRO A  34     2763   4292   2509   -163    -38    209       C  \\nATOM    269  CG  PRO A  34      69.117  54.687  -1.629  1.00 33.54           C  \\nANISOU  269  CG  PRO A  34     3811   5434   3498   -168     -6    183       C  \\nATOM    270  CD  PRO A  34      68.792  55.755  -2.630  1.00 29.54           C  \\nANISOU  270  CD  PRO A  34     3333   4978   2912   -189    -21    238       C  \\nATOM    271  N   ILE A  35      66.331  57.604   0.738  1.00 27.91           N  \\nANISOU  271  N   ILE A  35     3175   4533   2896   -174   -125    328       N  \\nATOM    272  CA  ILE A  35      66.413  58.882   1.442  1.00 31.14           C  \\nANISOU  272  CA  ILE A  35     3606   4894   3333   -186   -138    380       C  \\nATOM    273  C   ILE A  35      66.814  58.668   2.899  1.00 38.55           C  \\nANISOU  273  C   ILE A  35     4528   5793   4326   -176   -131    358       C  \\nATOM    274  O   ILE A  35      67.269  59.593   3.584  1.00 41.45           O  \\nANISOU  274  O   ILE A  35     4904   6130   4717   -192   -137    377       O  \\nATOM    275  CB  ILE A  35      65.095  59.688   1.337  1.00 36.91           C  \\nANISOU  275  CB  ILE A  35     4364   5592   4067   -166   -179    411       C  \\nATOM    276  CG1 ILE A  35      63.947  58.945   2.021  1.00 26.33           C  \\nANISOU  276  CG1 ILE A  35     3006   4229   2768   -131   -196    369       C  \\nATOM    277  CG2 ILE A  35      64.787  59.996  -0.117  1.00 27.26           C  \\nANISOU  277  CG2 ILE A  35     3159   4424   2775   -167   -192    445       C  \\nATOM    278  CD1 ILE A  35      62.600  59.672   1.937  1.00 22.88           C  \\nANISOU  278  CD1 ILE A  35     2582   3772   2340   -103   -237    393       C  \\nATOM    279  N   LYS A  36      66.662  57.430   3.358  1.00 39.19           N  \\nANISOU  279  N   LYS A  36     4586   5876   4427   -148   -118    317       N  \\nATOM    280  CA  LYS A  36      67.001  57.070   4.725  1.00 42.78           C  \\nANISOU  280  CA  LYS A  36     5027   6308   4919   -124   -109    306       C  \\nATOM    281  C   LYS A  36      67.115  55.550   4.806  1.00 28.88           C  \\nANISOU  281  C   LYS A  36     3242   4554   3176    -97    -80    274       C  \\nATOM    282  O   LYS A  36      66.250  54.816   4.327  1.00 35.54           O  \\nANISOU  282  O   LYS A  36     4084   5385   4034    -90    -77    251       O  \\nATOM    283  CB  LYS A  36      65.944  57.620   5.698  1.00 37.61           C  \\nANISOU  283  CB  LYS A  36     4390   5609   4290   -100   -131    317       C  \\nATOM    284  CG  LYS A  36      66.184  57.345   7.175  1.00 44.76           C  \\nANISOU  284  CG  LYS A  36     5287   6506   5214    -65   -122    311       C  \\nATOM    285  CD  LYS A  36      65.162  58.093   8.056  1.00 35.43           C  \\nANISOU  285  CD  LYS A  36     4124   5291   4045    -40   -140    318       C  \\nATOM    286  CE  LYS A  36      65.096  57.528   9.467  1.00 35.60           C  \\nANISOU  286  CE  LYS A  36     4138   5320   4070      9   -122    316       C  \\nATOM    287  NZ  LYS A  36      66.401  57.594  10.191  1.00 34.00           N  \\nANISOU  287  NZ  LYS A  36     3924   5151   3844     17   -128    304       N  \\nATOM    288  N   ARG A  37      68.199  55.085   5.404  1.00 26.89           N  \\nANISOU  288  N   ARG A  37     2968   4318   2931    -80    -61    268       N  \\nATOM    289  CA  ARG A  37      68.443  53.661   5.548  1.00 40.87           C  \\nANISOU  289  CA  ARG A  37     4718   6081   4729    -44    -29    247       C  \\nATOM    290  C   ARG A  37      69.084  53.360   6.889  1.00 32.47           C  \\nANISOU  290  C   ARG A  37     3640   5019   3679      0    -22    265       C  \\nATOM    291  O   ARG A  37      69.756  54.210   7.467  1.00 37.40           O  \\nANISOU  291  O   ARG A  37     4256   5673   4281     -6    -43    275       O  \\nATOM    292  CB  ARG A  37      69.360  53.166   4.431  1.00 36.01           C  \\nANISOU  292  CB  ARG A  37     4082   5509   4092    -56     -6    215       C  \\nATOM    293  CG  ARG A  37      68.718  53.145   3.071  1.00 31.94           C  \\nANISOU  293  CG  ARG A  37     3579   5007   3549    -83    -11    187       C  \\nATOM    294  CD  ARG A  37      69.519  52.283   2.129  1.00 37.03           C  \\nANISOU  294  CD  ARG A  37     4202   5692   4176    -76     22    139       C  \\nATOM    295  NE  ARG A  37      70.803  52.886   1.784  1.00 37.02           N  \\nANISOU  295  NE  ARG A  37     4179   5755   4133    -93     39    155       N  \\nATOM    296  CZ  ARG A  37      71.559  52.481   0.771  1.00 30.89           C  \\nANISOU  296  CZ  ARG A  37     3380   5037   3318    -93     71    120       C  \\nATOM    297  NH1 ARG A  37      71.146  51.481   0.008  1.00 33.49           N  \\nANISOU  297  NH1 ARG A  37     3714   5365   3644    -73     83     56       N  \\nATOM    298  NH2 ARG A  37      72.714  53.075   0.516  1.00 24.05           N  \\nANISOU  298  NH2 ARG A  37     2484   4232   2421   -114     94    142       N  \\nATOM    299  N   GLY A  38      68.871  52.143   7.376  1.00 28.10           N  \\nANISOU  299  N   GLY A  38     3081   4431   3162     46      7    270       N  \\nATOM    300  CA  GLY A  38      69.469  51.714   8.621  1.00 32.43           C  \\nANISOU  300  CA  GLY A  38     3618   4990   3714    104     16    301       C  \\nATOM    301  C   GLY A  38      68.867  50.433   9.158  1.00 42.28           C  \\nANISOU  301  C   GLY A  38     4873   6178   5014    151     56    328       C  \\nATOM    302  O   GLY A  38      68.281  49.646   8.412  1.00 30.78           O  \\nANISOU  302  O   GLY A  38     3419   4668   3606    135     81    304       O  \\nATOM    303  N   CYS A  39      69.013  50.232  10.466  1.00 41.02           N  \\nANISOU  303  N   CYS A  39     4716   6027   4844    210     63    377       N  \\nATOM    304  CA  CYS A  39      68.444  49.071  11.144  1.00 36.06           C  \\nANISOU  304  CA  CYS A  39     4098   5339   4265    260    112    428       C  \\nATOM    305  C   CYS A  39      67.148  49.462  11.821  1.00 32.52           C  \\nANISOU  305  C   CYS A  39     3671   4870   3817    252    121    460       C  \\nATOM    306  O   CYS A  39      66.951  50.633  12.137  1.00 32.25           O  \\nANISOU  306  O   CYS A  39     3643   4881   3729    236     83    449       O  \\nATOM    307  CB  CYS A  39      69.411  48.540  12.198  1.00 30.61           C  \\nANISOU  307  CB  CYS A  39     3397   4683   3550    345    121    479       C  \\nATOM    308  SG  CYS A  39      71.003  48.047  11.540  1.00 33.55           S  \\nANISOU  308  SG  CYS A  39     3730   5091   3926    371    113    444       S  \\nATOM    309  N   THR A  40      66.273  48.478  12.035  1.00 34.42           N  \\nANISOU  309  N   THR A  40     3916   5037   4125    263    174    497       N  \\nATOM    310  CA  THR A  40      65.006  48.690  12.727  1.00 32.22           C  \\nANISOU  310  CA  THR A  40     3645   4740   3856    260    198    535       C  \\nATOM    311  C   THR A  40      64.549  47.373  13.354  1.00 46.79           C  \\nANISOU  311  C   THR A  40     5493   6512   5774    296    274    608       C  \\nATOM    312  O   THR A  40      64.982  46.302  12.925  1.00 42.93           O  \\nANISOU  312  O   THR A  40     5000   5960   5352    305    303    607       O  \\nATOM    313  CB  THR A  40      63.920  49.213  11.756  1.00 37.46           C  \\nANISOU  313  CB  THR A  40     4299   5381   4552    186    178    478       C  \\nATOM    314  OG1 THR A  40      62.725  49.558  12.480  1.00 39.27           O  \\nANISOU  314  OG1 THR A  40     4527   5608   4787    189    199    512       O  \\nATOM    315  CG2 THR A  40      63.598  48.165  10.714  1.00 32.27           C  \\nANISOU  315  CG2 THR A  40     3626   4650   3986    146    201    438       C  \\nATOM    316  N   ASP A  41      63.691  47.441  14.374  1.00 42.34           N  \\nANISOU  316  N   ASP A  41     4934   5952   5201    321    313    673       N  \\nATOM    317  CA  ASP A  41      63.141  46.213  14.959  1.00 43.79           C  \\nANISOU  317  CA  ASP A  41     5118   6056   5464    346    399    757       C  \\nATOM    318  C   ASP A  41      61.811  45.811  14.328  1.00 40.37           C  \\nANISOU  318  C   ASP A  41     4657   5539   5144    270    435    731       C  \\nATOM    319  O   ASP A  41      61.641  44.671  13.895  1.00 47.46           O  \\nANISOU  319  O   ASP A  41     5544   6334   6155    246    480    733       O  \\nATOM    320  CB  ASP A  41      63.065  46.273  16.494  1.00 47.55           C  \\nANISOU  320  CB  ASP A  41     5612   6589   5867    428    439    862       C  \\nATOM    321  CG  ASP A  41      62.099  47.321  17.015  1.00 77.88           C  \\nANISOU  321  CG  ASP A  41     9448  10492   9650    416    433    855       C  \\nATOM    322  OD1 ASP A  41      61.351  46.976  17.956  1.00 99.11           O  \\nANISOU  322  OD1 ASP A  41    12137  13179  12341    449    506    941       O  \\nATOM    323  OD2 ASP A  41      62.097  48.474  16.520  1.00 69.38           O  \\nANISOU  323  OD2 ASP A  41     8368   9465   8528    380    363    771       O  \\nATOM    324  N   ALA A  42      60.886  46.758  14.248  1.00 27.50           N  \\nANISOU  324  N   ALA A  42     3010   3951   3489    232    410    697       N  \\nATOM    325  CA  ALA A  42      59.651  46.556  13.506  1.00 38.00           C  \\nANISOU  325  CA  ALA A  42     4299   5224   4916    156    423    651       C  \\nATOM    326  C   ALA A  42      59.704  47.418  12.251  1.00 46.01           C  \\nANISOU  326  C   ALA A  42     5305   6276   5901    106    336    544       C  \\nATOM    327  O   ALA A  42      60.195  48.553  12.288  1.00 33.62           O  \\nANISOU  327  O   ALA A  42     3756   4784   4232    125    279    526       O  \\nATOM    328  CB  ALA A  42      58.467  46.925  14.351  1.00 27.83           C  \\nANISOU  328  CB  ALA A  42     2987   3959   3629    161    466    702       C  \\nATOM    329  N   CYS A  43      59.218  46.883  11.134  1.00 50.47           N  \\nANISOU  329  N   CYS A  43     5839   6787   6550     43    325    473       N  \\nATOM    330  CA  CYS A  43      59.256  47.634   9.881  1.00 39.70           C  \\nANISOU  330  CA  CYS A  43     4469   5470   5146      3    245    381       C  \\nATOM    331  C   CYS A  43      58.351  48.853   9.916  1.00 38.15           C  \\nANISOU  331  C   CYS A  43     4256   5334   4904     -5    205    374       C  \\nATOM    332  O   CYS A  43      57.149  48.728  10.134  1.00 43.82           O  \\nANISOU  332  O   CYS A  43     4931   6035   5684    -26    231    380       O  \\nATOM    333  CB  CYS A  43      58.887  46.767   8.675  1.00 27.88           C  \\nANISOU  333  CB  CYS A  43     2939   3917   3736    -57    236    295       C  \\nATOM    334  SG  CYS A  43      59.222  47.648   7.075  1.00 37.61           S  \\nANISOU  334  SG  CYS A  43     4177   5231   4883    -86    139    193       S  \\nATOM    335  N   PRO A  44      58.932  50.039   9.694  1.00 39.87           N  \\nANISOU  335  N   PRO A  44     4505   5619   5026     11    147    360       N  \\nATOM    336  CA  PRO A  44      58.174  51.289   9.646  1.00 44.88           C  \\nANISOU  336  CA  PRO A  44     5132   6301   5620     12    104    351       C  \\nATOM    337  C   PRO A  44      57.107  51.270   8.560  1.00 40.39           C  \\nANISOU  337  C   PRO A  44     4516   5731   5097    -34     69    294       C  \\nATOM    338  O   PRO A  44      57.262  50.634   7.522  1.00 57.57           O  \\nANISOU  338  O   PRO A  44     6681   7894   7300    -71     50    238       O  \\nATOM    339  CB  PRO A  44      59.238  52.338   9.318  1.00 35.14           C  \\nANISOU  339  CB  PRO A  44     3943   5113   4295     25     50    340       C  \\nATOM    340  CG  PRO A  44      60.507  51.730   9.774  1.00 39.03           C  \\nANISOU  340  CG  PRO A  44     4460   5599   4769     47     76    362       C  \\nATOM    341  CD  PRO A  44      60.371  50.264   9.502  1.00 35.53           C  \\nANISOU  341  CD  PRO A  44     3995   5097   4408     31    121    355       C  \\nATOM    342  N   LYS A  45      56.021  51.979   8.825  1.00 37.97           N  \\nANISOU  342  N   LYS A  45     4181   5448   4798    -24     59    301       N  \\nATOM    343  CA  LYS A  45      54.879  52.004   7.946  1.00 42.27           C  \\nANISOU  343  CA  LYS A  45     4668   6007   5388    -57     22    251       C  \\nATOM    344  C   LYS A  45      55.076  52.989   6.799  1.00 37.69           C  \\nANISOU  344  C   LYS A  45     4108   5478   4734    -56    -62    216       C  \\nATOM    345  O   LYS A  45      55.727  54.024   6.950  1.00 25.69           O  \\nANISOU  345  O   LYS A  45     2641   3980   3141    -25    -86    245       O  \\nATOM    346  CB  LYS A  45      53.566  52.233   8.729  1.00 58.16           C  \\nANISOU  346  CB  LYS A  45     6623   8025   7449    -42     54    277       C  \\nATOM    347  CG  LYS A  45      53.477  53.264   9.877  1.00 81.35           C  \\nANISOU  347  CG  LYS A  45     9587  10990  10332     20     74    330       C  \\nATOM    348  CD  LYS A  45      54.258  53.202  11.205  1.00 84.48           C  \\nANISOU  348  CD  LYS A  45    10034  11380  10686     64    133    390       C  \\nATOM    349  CE  LYS A  45      55.712  53.700  11.189  1.00 51.05           C  \\nANISOU  349  CE  LYS A  45     5874   7156   6365     83     97    391       C  \\nATOM    350  NZ  LYS A  45      55.958  54.904  12.019  1.00 40.67           N  \\nANISOU  350  NZ  LYS A  45     4598   5876   4979    136     84    404       N  \\nATOM    351  N   SER A  46      54.533  52.650   5.637  1.00 32.32           N  \\nANISOU  351  N   SER A  46     3387   4819   4075    -90   -107    153       N  \\nATOM    352  CA  SER A  46      54.625  53.544   4.496  1.00 33.06           C  \\nANISOU  352  CA  SER A  46     3499   4974   4090    -82   -184    133       C  \\nATOM    353  C   SER A  46      53.680  54.714   4.690  1.00 36.55           C  \\nANISOU  353  C   SER A  46     3922   5446   4518    -42   -219    162       C  \\nATOM    354  O   SER A  46      52.792  54.670   5.539  1.00 50.46           O  \\nANISOU  354  O   SER A  46     5640   7193   6340    -29   -186    177       O  \\nATOM    355  CB  SER A  46      54.291  52.800   3.206  1.00 29.10           C  \\nANISOU  355  CB  SER A  46     2955   4502   3599   -121   -228     49       C  \\nATOM    356  OG  SER A  46      55.353  51.929   2.845  1.00 46.28           O  \\nANISOU  356  OG  SER A  46     5162   6654   5767   -146   -204     16       O  \\nATOM    357  N   SER A  47      53.884  55.772   3.914  1.00 28.97           N  \\nANISOU  357  N   SER A  47     2998   4527   3482    -17   -279    177       N  \\nATOM    358  CA  SER A  47      52.941  56.883   3.879  1.00 27.13           C  \\nANISOU  358  CA  SER A  47     2747   4321   3240     30   -321    202       C  \\nATOM    359  C   SER A  47      52.541  57.139   2.435  1.00 33.34           C  \\nANISOU  359  C   SER A  47     3514   5176   3977     34   -401    176       C  \\nATOM    360  O   SER A  47      52.971  56.431   1.522  1.00 35.36           O  \\nANISOU  360  O   SER A  47     3771   5464   4201     -1   -419    131       O  \\nATOM    361  CB  SER A  47      53.568  58.140   4.464  1.00 26.56           C  \\nANISOU  361  CB  SER A  47     2746   4219   3126     70   -315    262       C  \\nATOM    362  OG  SER A  47      54.483  58.713   3.544  1.00 32.86           O  \\nANISOU  362  OG  SER A  47     3603   5031   3849     64   -349    284       O  \\nATOM    363  N   LEU A  48      51.716  58.152   2.223  1.00 31.11           N  \\nANISOU  363  N   LEU A  48     3216   4924   3681     87   -449    205       N  \\nATOM    364  CA  LEU A  48      51.325  58.539   0.870  1.00 38.00           C  \\nANISOU  364  CA  LEU A  48     4075   5874   4488    110   -531    198       C  \\nATOM    365  C   LEU A  48      52.509  58.975  -0.004  1.00 31.89           C  \\nANISOU  365  C   LEU A  48     3387   5118   3613    106   -546    236       C  \\nATOM    366  O   LEU A  48      52.432  58.894  -1.224  1.00 44.49           O  \\nANISOU  366  O   LEU A  48     4976   6793   5137    111   -601    218       O  \\nATOM    367  CB  LEU A  48      50.301  59.673   0.910  1.00 39.91           C  \\nANISOU  367  CB  LEU A  48     4293   6134   4735    185   -576    241       C  \\nATOM    368  CG  LEU A  48      48.830  59.363   1.138  1.00 58.10           C  \\nANISOU  368  CG  LEU A  48     6484   8477   7116    203   -598    196       C  \\nATOM    369  CD1 LEU A  48      48.025  60.029   0.045  1.00 68.02           C  \\nANISOU  369  CD1 LEU A  48     7704   9820   8320    264   -694    205       C  \\nATOM    370  CD2 LEU A  48      48.580  57.867   1.169  1.00 77.36           C  \\nANISOU  370  CD2 LEU A  48     8849  10926   9619    127   -573    109       C  \\nATOM    371  N   LEU A  49      53.585  59.451   0.623  1.00 30.96           N  \\nANISOU  371  N   LEU A  49     3343   4934   3486     99   -496    287       N  \\nATOM    372  CA  LEU A  49      54.746  59.985  -0.100  1.00 32.69           C  \\nANISOU  372  CA  LEU A  49     3636   5163   3622     90   -497    335       C  \\nATOM    373  C   LEU A  49      55.982  59.079  -0.006  1.00 35.25           C  \\nANISOU  373  C   LEU A  49     3982   5474   3937     34   -445    302       C  \\nATOM    374  O   LEU A  49      56.873  59.129  -0.855  1.00 36.08           O  \\nANISOU  374  O   LEU A  49     4124   5615   3969     17   -444    317       O  \\nATOM    375  CB  LEU A  49      55.108  61.367   0.443  1.00 24.80           C  \\nANISOU  375  CB  LEU A  49     2698   4095   2628    122   -485    416       C  \\nATOM    376  CG  LEU A  49      54.139  62.490   0.096  1.00 40.75           C  \\nANISOU  376  CG  LEU A  49     4718   6122   4642    191   -538    469       C  \\nATOM    377  CD1 LEU A  49      54.562  63.793   0.768  1.00 31.46           C  \\nANISOU  377  CD1 LEU A  49     3606   4851   3496    216   -517    534       C  \\nATOM    378  CD2 LEU A  49      54.085  62.640  -1.422  1.00 33.57           C  \\nANISOU  378  CD2 LEU A  49     3818   5301   3638    209   -592    499       C  \\nATOM    379  N   VAL A  50      56.025  58.251   1.033  1.00 33.01           N  \\nANISOU  379  N   VAL A  50     3674   5142   3726     11   -397    264       N  \\nATOM    380  CA  VAL A  50      57.193  57.431   1.312  1.00 30.57           C  \\nANISOU  380  CA  VAL A  50     3384   4810   3419    -28   -346    243       C  \\nATOM    381  C   VAL A  50      56.916  55.924   1.281  1.00 27.73           C  \\nANISOU  381  C   VAL A  50     2974   4451   3111    -59   -326    165       C  \\nATOM    382  O   VAL A  50      55.974  55.433   1.891  1.00 44.21           O  \\nANISOU  382  O   VAL A  50     5011   6513   5274    -59   -316    142       O  \\nATOM    383  CB  VAL A  50      57.834  57.842   2.662  1.00 35.33           C  \\nANISOU  383  CB  VAL A  50     4020   5348   4056    -22   -299    282       C  \\nATOM    384  CG1 VAL A  50      58.902  56.851   3.081  1.00 33.73           C  \\nANISOU  384  CG1 VAL A  50     3823   5128   3867    -50   -249    259       C  \\nATOM    385  CG2 VAL A  50      58.421  59.247   2.549  1.00 30.60           C  \\nANISOU  385  CG2 VAL A  50     3476   4736   3415    -10   -314    343       C  \\nATOM    386  N   LYS A  51      57.745  55.200   0.541  1.00 20.99           N  \\nANISOU  386  N   LYS A  51     2131   3623   2222    -84   -316    125       N  \\nATOM    387  CA  LYS A  51      57.723  53.745   0.562  1.00 30.80           C  \\nANISOU  387  CA  LYS A  51     3337   4841   3525   -113   -288     49       C  \\nATOM    388  C   LYS A  51      58.820  53.234   1.501  1.00 31.26           C  \\nANISOU  388  C   LYS A  51     3422   4838   3617   -117   -221     71       C  \\nATOM    389  O   LYS A  51      59.939  53.777   1.519  1.00 35.08           O  \\nANISOU  389  O   LYS A  51     3949   5334   4046   -110   -208    112       O  \\nATOM    390  CB  LYS A  51      57.901  53.187  -0.865  1.00 28.20           C  \\nANISOU  390  CB  LYS A  51     2998   4580   3136   -128   -321    -29       C  \\nATOM    391  CG  LYS A  51      58.097  51.682  -0.942  1.00 54.20           C  \\nANISOU  391  CG  LYS A  51     6263   7834   6496   -158   -288   -120       C  \\nATOM    392  CD  LYS A  51      56.918  50.950  -0.352  1.00 73.95           C  \\nANISOU  392  CD  LYS A  51     8703  10278   9118   -181   -282   -159       C  \\nATOM    393  CE  LYS A  51      55.636  51.330  -1.063  1.00 90.55           C  \\nANISOU  393  CE  LYS A  51    10752  12449  11205   -182   -356   -198       C  \\nATOM    394  NZ  LYS A  51      54.459  50.694  -0.412  1.00 94.04           N  \\nANISOU  394  NZ  LYS A  51    11120  12836  11776   -210   -343   -230       N  \\nATOM    395  N   VAL A  52      58.503  52.203   2.287  1.00 40.94           N  \\nANISOU  395  N   VAL A  52     4619   6002   4937   -127   -178     51       N  \\nATOM    396  CA  VAL A  52      59.501  51.556   3.148  1.00 33.26           C  \\nANISOU  396  CA  VAL A  52     3667   4975   3994   -119   -117     75       C  \\nATOM    397  C   VAL A  52      59.680  50.066   2.834  1.00 36.48           C  \\nANISOU  397  C   VAL A  52     4054   5339   4470   -139    -85      8       C  \\nATOM    398  O   VAL A  52      58.750  49.289   3.026  1.00 46.16           O  \\nANISOU  398  O   VAL A  52     5237   6515   5785   -161    -70    -23       O  \\nATOM    399  CB  VAL A  52      59.134  51.694   4.639  1.00 36.26           C  \\nANISOU  399  CB  VAL A  52     4045   5308   4424    -97    -78    140       C  \\nATOM    400  CG1 VAL A  52      60.336  51.312   5.522  1.00 26.64           C  \\nANISOU  400  CG1 VAL A  52     2857   4062   3203    -72    -30    179       C  \\nATOM    401  CG2 VAL A  52      58.656  53.113   4.944  1.00 19.87           C  \\nANISOU  401  CG2 VAL A  52     1983   3264   2304    -76   -112    184       C  \\nATOM    402  N   VAL A  53      60.866  49.684   2.343  1.00 44.97           N  \\nANISOU  402  N   VAL A  53     5152   6426   5507   -133    -71    -17       N  \\nATOM    403  CA  VAL A  53      61.270  48.271   2.213  1.00 29.52           C  \\nANISOU  403  CA  VAL A  53     3184   4411   3622   -137    -29    -75       C  \\nATOM    404  C   VAL A  53      61.904  47.780   3.506  1.00 28.61           C  \\nANISOU  404  C   VAL A  53     3084   4228   3560   -104     32     -6       C  \\nATOM    405  O   VAL A  53      62.669  48.497   4.144  1.00 46.84           O  \\nANISOU  405  O   VAL A  53     5418   6566   5812    -75     36     62       O  \\nATOM    406  CB  VAL A  53      62.288  48.020   1.030  1.00 84.88           C  \\nANISOU  406  CB  VAL A  53    10209  11476  10565   -133    -38   -143       C  \\nATOM    407  CG1 VAL A  53      63.722  47.562   1.518  1.00 19.80           C  \\nANISOU  407  CG1 VAL A  53     1986   3209   2326    -96     14   -115       C  \\nATOM    408  CG2 VAL A  53      61.717  47.008   0.055  1.00 84.82           C  \\nANISOU  408  CG2 VAL A  53    10172  11454  10603   -160    -51   -264       C  \\nATOM    409  N   CYS A  54      61.572  46.560   3.899  1.00 43.68           N  \\nANISOU  409  N   CYS A  54     4975   6044   5580   -109     78    -22       N  \\nATOM    410  CA  CYS A  54      62.262  45.901   5.000  1.00 31.22           C  \\nANISOU  410  CA  CYS A  54     3412   4400   4048    -65    139     47       C  \\nATOM    411  C   CYS A  54      62.708  44.500   4.578  1.00 28.54           C  \\nANISOU  411  C   CYS A  54     3069   3980   3796    -60    178    -14       C  \\nATOM    412  O   CYS A  54      61.997  43.795   3.872  1.00 43.76           O  \\nANISOU  412  O   CYS A  54     4970   5858   5797   -103    176   -101       O  \\nATOM    413  CB  CYS A  54      61.393  45.865   6.259  1.00 31.70           C  \\nANISOU  413  CB  CYS A  54     3464   4412   4167    -60    177    131       C  \\nATOM    414  SG  CYS A  54      61.246  47.473   7.119  1.00 31.99           S  \\nANISOU  414  SG  CYS A  54     3519   4537   4100    -35    146    211       S  \\nATOM    415  N   CYS A  55      63.905  44.116   4.993  1.00 32.44           N  \\nANISOU  415  N   CYS A  55     3585   4461   4281     -5    211     23       N  \\nATOM    416  CA  CYS A  55      64.487  42.838   4.594  1.00 33.81           C  \\nANISOU  416  CA  CYS A  55     3758   4556   4534     16    250    -34       C  \\nATOM    417  C   CYS A  55      65.424  42.390   5.703  1.00 28.22           C  \\nANISOU  417  C   CYS A  55     3068   3808   3845     92    298     63       C  \\nATOM    418  O   CYS A  55      65.892  43.219   6.486  1.00 30.72           O  \\nANISOU  418  O   CYS A  55     3395   4198   4079    126    285    146       O  \\nATOM    419  CB  CYS A  55      65.239  42.992   3.266  1.00 24.54           C  \\nANISOU  419  CB  CYS A  55     2581   3458   3284     13    216   -137       C  \\nATOM    420  SG  CYS A  55      66.457  44.351   3.246  1.00 38.12           S  \\nANISOU  420  SG  CYS A  55     4314   5324   4848     42    183    -84       S  \\nATOM    421  N   ASN A  56      65.701  41.092   5.781  1.00 40.93           N  \\nANISOU  421  N   ASN A  56     4681   5306   5565    124    351     52       N  \\nATOM    422  CA  ASN A  56      66.455  40.570   6.920  1.00 42.61           C  \\nANISOU  422  CA  ASN A  56     4911   5474   5804    208    400    162       C  \\nATOM    423  C   ASN A  56      67.720  39.763   6.615  1.00 45.02           C  \\nANISOU  423  C   ASN A  56     5219   5752   6134    280    423    132       C  \\nATOM    424  O   ASN A  56      68.150  38.962   7.449  1.00 46.78           O  \\nANISOU  424  O   ASN A  56     5455   5899   6422    353    472    215       O  \\nATOM    425  CB  ASN A  56      65.541  39.772   7.854  1.00 47.63           C  \\nANISOU  425  CB  ASN A  56     5554   5982   6561    206    463    246       C  \\nATOM    426  CG  ASN A  56      64.852  38.628   7.150  1.00 67.50           C  \\nANISOU  426  CG  ASN A  56     8059   8356   9233    155    498    157       C  \\nATOM    427  OD1 ASN A  56      65.074  38.394   5.959  1.00 82.89           O  \\nANISOU  427  OD1 ASN A  56     9997  10308  11191    129    470     22       O  \\nATOM    428  ND2 ASN A  56      64.009  37.902   7.882  1.00 52.13           N  \\nANISOU  428  ND2 ASN A  56     6111   6285   7412    138    562    229       N  \\nATOM    429  N   LYS A  57      68.319  39.968   5.441  1.00 33.36           N  \\nANISOU  429  N   LYS A  57     3728   4344   4604    267    391     20       N  \\nATOM    430  CA  LYS A  57      69.663  39.443   5.210  1.00 40.25           C  \\nANISOU  430  CA  LYS A  57     4593   5227   5473    346    410     -3       C  \\nATOM    431  C   LYS A  57      70.672  40.596   5.208  1.00 47.26           C  \\nANISOU  431  C   LYS A  57     5462   6277   6216    364    368     22       C  \\nATOM    432  O   LYS A  57      70.284  41.760   5.081  1.00 37.83           O  \\nANISOU  432  O   LYS A  57     4267   5175   4933    306    323     28       O  \\nATOM    433  CB  LYS A  57      69.747  38.595   3.927  1.00 39.15           C  \\nANISOU  433  CB  LYS A  57     4447   5034   5395    333    424   -152       C  \\nATOM    434  CG  LYS A  57      69.139  39.230   2.687  1.00 64.01           C  \\nANISOU  434  CG  LYS A  57     7586   8264   8473    248    376   -269       C  \\nATOM    435  CD  LYS A  57      67.711  38.739   2.468  1.00 74.30           C  \\nANISOU  435  CD  LYS A  57     8891   9463   9877    174    375   -325       C  \\nATOM    436  CE  LYS A  57      66.818  39.800   1.836  1.00 59.33           C  \\nANISOU  436  CE  LYS A  57     6984   7672   7887     94    312   -364       C  \\nATOM    437  NZ  LYS A  57      65.409  39.654   2.306  1.00 59.93           N  \\nANISOU  437  NZ  LYS A  57     7051   7666   8054     32    312   -341       N  \\nATOM    438  N   ASP A  58      71.955  40.274   5.373  1.00 35.72           N  \\nANISOU  438  N   ASP A  58     3981   4847   4743    447    383     37       N  \\nATOM    439  CA  ASP A  58      73.019  41.283   5.443  1.00 33.51           C  \\nANISOU  439  CA  ASP A  58     3669   4716   4347    463    349     59       C  \\nATOM    440  C   ASP A  58      73.048  42.233   4.252  1.00 43.98           C  \\nANISOU  440  C   ASP A  58     4982   6149   5581    388    317    -23       C  \\nATOM    441  O   ASP A  58      73.141  41.798   3.097  1.00 33.62           O  \\nANISOU  441  O   ASP A  58     3663   4835   4275    376    332   -126       O  \\nATOM    442  CB  ASP A  58      74.395  40.616   5.562  1.00 48.98           C  \\nANISOU  442  CB  ASP A  58     5594   6692   6325    564    374     62       C  \\nATOM    443  CG  ASP A  58      74.868  40.495   7.000  1.00 54.39           C  \\nANISOU  443  CG  ASP A  58     6273   7379   7013    649    373    185       C  \\nATOM    444  OD1 ASP A  58      74.027  40.589   7.912  1.00 42.26           O  \\nANISOU  444  OD1 ASP A  58     4771   5796   5489    639    370    268       O  \\nATOM    445  OD2 ASP A  58      76.084  40.297   7.212  1.00 72.21           O  \\nANISOU  445  OD2 ASP A  58     8488   9695   9255    731    374    199       O  \\nATOM    446  N   LYS A  59      72.998  43.529   4.555  1.00 38.54           N  \\nANISOU  446  N   LYS A  59     4289   5552   4804    343    275     25       N  \\nATOM    447  CA  LYS A  59      73.133  44.589   3.558  1.00 39.02           C  \\nANISOU  447  CA  LYS A  59     4338   5716   4770    277    248    -20       C  \\nATOM    448  C   LYS A  59      72.119  44.448   2.438  1.00 42.86           C  \\nANISOU  448  C   LYS A  59     4849   6178   5259    219    243   -101       C  \\nATOM    449  O   LYS A  59      72.399  44.783   1.287  1.00 40.67           O  \\nANISOU  449  O   LYS A  59     4561   5978   4914    192    240   -165       O  \\nATOM    450  CB  LYS A  59      74.541  44.615   2.974  1.00 39.99           C  \\nANISOU  450  CB  LYS A  59     4413   5930   4851    309    266    -55       C  \\nATOM    451  CG  LYS A  59      75.648  44.980   3.955  1.00 50.56           C  \\nANISOU  451  CG  LYS A  59     5708   7329   6172    356    257     13       C  \\nATOM    452  CD  LYS A  59      76.952  45.202   3.194  1.00 55.88           C  \\nANISOU  452  CD  LYS A  59     6322   8111   6800    365    276    -29       C  \\nATOM    453  CE  LYS A  59      78.149  45.373   4.107  1.00 64.90           C  \\nANISOU  453  CE  LYS A  59     7402   9317   7940    420    265     20       C  \\nATOM    454  NZ  LYS A  59      79.386  45.625   3.296  1.00 72.10           N  \\nANISOU  454  NZ  LYS A  59     8242  10341   8814    419    291    -24       N  \\nATOM    455  N   CYS A  60      70.939  43.950   2.784  1.00 32.37           N  \\nANISOU  455  N   CYS A  60     3547   4750   4003    202    242    -98       N  \\nATOM    456  CA  CYS A  60      69.913  43.664   1.789  1.00 40.34           C  \\nANISOU  456  CA  CYS A  60     4567   5730   5029    150    231   -188       C  \\nATOM    457  C   CYS A  60      69.146  44.909   1.391  1.00 28.46           C  \\nANISOU  457  C   CYS A  60     3073   4301   3440     84    180   -175       C  \\nATOM    458  O   CYS A  60      68.394  44.881   0.428  1.00 37.85           O  \\nANISOU  458  O   CYS A  60     4265   5505   4612     45    158   -251       O  \\nATOM    459  CB  CYS A  60      68.920  42.669   2.354  1.00 31.83           C  \\nANISOU  459  CB  CYS A  60     3503   4513   4079    148    252   -188       C  \\nATOM    460  SG  CYS A  60      68.108  43.300   3.850  1.00 33.33           S  \\nANISOU  460  SG  CYS A  60     3707   4674   4284    137    243    -53       S  \\nATOM    461  N   ASN A  61      69.310  45.982   2.160  1.00 29.75           N  \\nANISOU  461  N   ASN A  61     3240   4509   3554     78    160    -83       N  \\nATOM    462  CA  ASN A  61      68.617  47.236   1.887  1.00 31.50           C  \\nANISOU  462  CA  ASN A  61     3475   4788   3707     26    114    -58       C  \\nATOM    463  C   ASN A  61      69.452  48.197   1.033  1.00 31.36           C  \\nANISOU  463  C   ASN A  61     3451   4880   3584      8    103    -60       C  \\nATOM    464  O   ASN A  61      70.395  47.762   0.376  1.00 27.49           O  \\nANISOU  464  O   ASN A  61     2942   4432   3070     28    132   -105       O  \\nATOM    465  CB  ASN A  61      68.180  47.909   3.188  1.00 35.67           C  \\nANISOU  465  CB  ASN A  61     4014   5290   4248     27    100     32       C  \\nATOM    466  CG  ASN A  61      69.350  48.465   3.987  1.00 40.90           C  \\nANISOU  466  CG  ASN A  61     4668   5997   4877     57    103     91       C  \\nATOM    467  OD1 ASN A  61      70.491  47.989   3.880  1.00 33.94           O  \\nANISOU  467  OD1 ASN A  61     3763   5139   3993     91    127     77       O  \\nATOM    468  ND2 ASN A  61      69.067  49.482   4.801  1.00 22.67           N  \\nANISOU  468  ND2 ASN A  61     2370   3703   2542     45     76    150       N  \\nATOM    469  OXT ASN A  61      69.225  49.409   0.972  1.00 22.04           O  \\nANISOU  469  OXT ASN A  61     2283   3745   2345    -26     73    -13       O  \\nTER     470      ASN A  61                                                      \\nATOM    471  N   LEU B   1      49.351  60.011  24.487  1.00 25.95           N  \\nANISOU  471  N   LEU B   1     2639   4650   2570    935    648    410       N  \\nATOM    472  CA  LEU B   1      49.863  60.966  23.507  1.00 44.64           C  \\nANISOU  472  CA  LEU B   1     5045   6930   4986    900    524    322       C  \\nATOM    473  C   LEU B   1      49.160  60.811  22.167  1.00 42.48           C  \\nANISOU  473  C   LEU B   1     4712   6576   4854    828    495    339       C  \\nATOM    474  O   LEU B   1      48.889  59.702  21.721  1.00 43.40           O  \\nANISOU  474  O   LEU B   1     4780   6675   5037    764    535    415       O  \\nATOM    475  CB  LEU B   1      51.381  60.814  23.313  1.00 25.79           C  \\nANISOU  475  CB  LEU B   1     2733   4512   2553    859    449    314       C  \\nATOM    476  CG  LEU B   1      51.969  61.760  22.249  1.00 42.34           C  \\nANISOU  476  CG  LEU B   1     4868   6514   4706    812    333    238       C  \\nATOM    477  CD1 LEU B   1      51.792  63.216  22.673  1.00 27.53           C  \\nANISOU  477  CD1 LEU B   1     3022   4637   2803    882    296    127       C  \\nATOM    478  CD2 LEU B   1      53.436  61.455  21.905  1.00 33.48           C  \\nANISOU  478  CD2 LEU B   1     3799   5363   3558    756    270    241       C  \\nATOM    479  N   LYS B   2      48.862  61.936  21.534  1.00 37.20           N  \\nANISOU  479  N   LYS B   2     4046   5857   4231    843    423    265       N  \\nATOM    480  CA  LYS B   2      48.293  61.941  20.194  1.00 41.24           C  \\nANISOU  480  CA  LYS B   2     4508   6303   4858    787    374    273       C  \\nATOM    481  C   LYS B   2      49.254  62.631  19.229  1.00 35.20           C  \\nANISOU  481  C   LYS B   2     3814   5455   4105    746    262    234       C  \\nATOM    482  O   LYS B   2      49.772  63.719  19.510  1.00 42.33           O  \\nANISOU  482  O   LYS B   2     4781   6334   4970    788    216    167       O  \\nATOM    483  CB  LYS B   2      46.940  62.661  20.177  1.00 26.62           C  \\nANISOU  483  CB  LYS B   2     2586   4470   3059    851    392    241       C  \\nATOM    484  CG  LYS B   2      45.786  61.874  20.767  1.00 42.98           C  \\nANISOU  484  CG  LYS B   2     4555   6617   5157    867    504    292       C  \\nATOM    485  CD  LYS B   2      44.452  62.360  20.210  1.00 53.56           C  \\nANISOU  485  CD  LYS B   2     5798   7961   6590    897    497    269       C  \\nATOM    486  CE  LYS B   2      43.269  61.912  21.067  1.00 65.07           C  \\nANISOU  486  CE  LYS B   2     7150   9510   8062    939    621    300       C  \\nATOM    487  NZ  LYS B   2      43.000  62.830  22.222  1.00 54.09           N  \\nANISOU  487  NZ  LYS B   2     5780   8182   6589   1060    671    245       N  \\nATOM    488  N   CYS B   3      49.487  61.998  18.090  1.00 34.08           N  \\nANISOU  488  N   CYS B   3     3658   5270   4021    663    223    271       N  \\nATOM    489  CA  CYS B   3      50.347  62.568  17.054  1.00 35.30           C  \\nANISOU  489  CA  CYS B   3     3871   5353   4187    620    128    249       C  \\nATOM    490  C   CYS B   3      49.644  62.599  15.702  1.00 32.72           C  \\nANISOU  490  C   CYS B   3     3495   4995   3940    587     79    263       C  \\nATOM    491  O   CYS B   3      48.827  61.731  15.401  1.00 41.28           O  \\nANISOU  491  O   CYS B   3     4501   6108   5076    560    111    293       O  \\nATOM    492  CB  CYS B   3      51.625  61.738  16.921  1.00 34.40           C  \\nANISOU  492  CB  CYS B   3     3801   5231   4038    554    119    277       C  \\nATOM    493  SG  CYS B   3      52.590  61.598  18.447  1.00 29.97           S  \\nANISOU  493  SG  CYS B   3     3294   4725   3368    596    161    267       S  \\nATOM    494  N   HIS B   4      49.957  63.599  14.889  1.00 21.55           N  \\nANISOU  494  N   HIS B   4     2125   3524   2538    589      1    241       N  \\nATOM    495  CA  HIS B   4      49.589  63.555  13.477  1.00 31.79           C  \\nANISOU  495  CA  HIS B   4     3392   4802   3885    554    -58    263       C  \\nATOM    496  C   HIS B   4      50.285  62.331  12.847  1.00 35.88           C  \\nANISOU  496  C   HIS B   4     3908   5327   4397    463    -59    292       C  \\nATOM    497  O   HIS B   4      51.453  62.066  13.137  1.00 36.73           O  \\nANISOU  497  O   HIS B   4     4074   5420   4460    431    -52    295       O  \\nATOM    498  CB  HIS B   4      50.015  64.843  12.759  1.00 21.47           C  \\nANISOU  498  CB  HIS B   4     2151   3428   2579    573   -133    255       C  \\nATOM    499  CG  HIS B   4      49.299  66.078  13.226  1.00 34.19           C  \\nANISOU  499  CG  HIS B   4     3766   5012   4214    666   -138    223       C  \\nATOM    500  ND1 HIS B   4      47.935  66.245  13.106  1.00 39.14           N  \\nANISOU  500  ND1 HIS B   4     4313   5671   4887    728   -133    223       N  \\nATOM    501  CD2 HIS B   4      49.767  67.218  13.787  1.00 30.02           C  \\nANISOU  501  CD2 HIS B   4     3307   4422   3676    711   -149    182       C  \\nATOM    502  CE1 HIS B   4      47.591  67.428  13.589  1.00 38.87           C  \\nANISOU  502  CE1 HIS B   4     4303   5597   4870    815   -138    188       C  \\nATOM    503  NE2 HIS B   4      48.684  68.039  14.006  1.00 36.95           N  \\nANISOU  503  NE2 HIS B   4     4153   5290   4595    804   -147    159       N  \\nATOM    504  N   ASN B   5      49.580  61.573  12.008  1.00 28.80           N  \\nANISOU  504  N   ASN B   5     2941   4454   3547    426    -69    305       N  \\nATOM    505  CA  ASN B   5      50.173  60.351  11.445  1.00 35.62           C  \\nANISOU  505  CA  ASN B   5     3800   5319   4415    345    -64    318       C  \\nATOM    506  C   ASN B   5      50.060  60.185   9.921  1.00 34.36           C  \\nANISOU  506  C   ASN B   5     3620   5163   4271    303   -135    311       C  \\nATOM    507  O   ASN B   5      50.280  59.097   9.398  1.00 36.56           O  \\nANISOU  507  O   ASN B   5     3875   5447   4567    241   -130    305       O  \\nATOM    508  CB  ASN B   5      49.626  59.105  12.159  1.00 25.59           C  \\nANISOU  508  CB  ASN B   5     2463   4073   3187    322     19    333       C  \\nATOM    509  CG  ASN B   5      48.147  58.880  11.889  1.00 38.87           C  \\nANISOU  509  CG  ASN B   5     4035   5789   4944    327     27    323       C  \\nATOM    510  OD1 ASN B   5      47.368  59.835  11.779  1.00 33.69           O  \\nANISOU  510  OD1 ASN B   5     3350   5152   4297    385     -5    308       O  \\nATOM    511  ND2 ASN B   5      47.753  57.614  11.777  1.00 32.38           N  \\nANISOU  511  ND2 ASN B   5     3145   4972   4186    265     70    328       N  \\nATOM    512  N   LYS B   6      49.707  61.262   9.229  1.00 34.59           N  \\nANISOU  512  N   LYS B   6     3659   5191   4294    344   -200    311       N  \\nATOM    513  CA  LYS B   6      49.613  61.281   7.769  1.00 40.60           C  \\nANISOU  513  CA  LYS B   6     4409   5972   5046    322   -275    311       C  \\nATOM    514  C   LYS B   6      50.307  62.539   7.282  1.00 31.70           C  \\nANISOU  514  C   LYS B   6     3368   4806   3872    352   -324    340       C  \\nATOM    515  O   LYS B   6      50.632  63.414   8.087  1.00 40.87           O  \\nANISOU  515  O   LYS B   6     4581   5920   5029    390   -305    346       O  \\nATOM    516  CB  LYS B   6      48.151  61.334   7.319  1.00 46.53           C  \\nANISOU  516  CB  LYS B   6     5061   6775   5845    357   -308    296       C  \\nATOM    517  CG  LYS B   6      47.237  60.308   7.966  1.00 44.19           C  \\nANISOU  517  CG  LYS B   6     4662   6509   5618    334   -248    271       C  \\nATOM    518  CD  LYS B   6      47.489  58.915   7.417  1.00 33.89           C  \\nANISOU  518  CD  LYS B   6     3326   5215   4337    244   -240    244       C  \\nATOM    519  CE  LYS B   6      46.531  57.918   8.060  1.00 57.71           C  \\nANISOU  519  CE  LYS B   6     6237   8248   7445    213   -173    227       C  \\nATOM    520  NZ  LYS B   6      46.663  56.563   7.459  1.00 70.91           N  \\nANISOU  520  NZ  LYS B   6     7870   9912   9162    123   -169    189       N  \\nATOM    521  N   LEU B   7      50.532  62.660   5.978  1.00 31.38           N  \\nANISOU  521  N   LEU B   7     3343   4784   3796    335   -385    358       N  \\nATOM    522  CA  LEU B   7      51.132  63.904   5.476  1.00 42.33           C  \\nANISOU  522  CA  LEU B   7     4810   6126   5147    363   -422    403       C  \\nATOM    523  C   LEU B   7      50.102  64.957   5.024  1.00 31.59           C  \\nANISOU  523  C   LEU B   7     3431   4767   3803    447   -475    433       C  \\nATOM    524  O   LEU B   7      50.449  66.053   4.582  1.00 39.07           O  \\nANISOU  524  O   LEU B   7     4444   5666   4734    480   -504    483       O  \\nATOM    525  CB  LEU B   7      52.230  63.659   4.435  1.00 48.84           C  \\nANISOU  525  CB  LEU B   7     5684   6961   5910    305   -443    426       C  \\nATOM    526  CG  LEU B   7      52.078  62.651   3.310  1.00 49.23           C  \\nANISOU  526  CG  LEU B   7     5690   7090   5927    265   -474    405       C  \\nATOM    527  CD1 LEU B   7      52.289  61.236   3.825  1.00 72.12           C  \\nANISOU  527  CD1 LEU B   7     8549  10000   8852    205   -425    350       C  \\nATOM    528  CD2 LEU B   7      50.720  62.808   2.682  1.00 31.44           C  \\nANISOU  528  CD2 LEU B   7     3366   4896   3683    318   -533    401       C  \\nATOM    529  N   VAL B   8      48.827  64.612   5.155  1.00 24.87           N  \\nANISOU  529  N   VAL B   8     2486   3970   2993    483   -483    405       N  \\nATOM    530  CA  VAL B   8      47.778  65.609   5.053  1.00 40.89           C  \\nANISOU  530  CA  VAL B   8     4484   5999   5052    580   -521    425       C  \\nATOM    531  C   VAL B   8      47.588  66.185   6.467  1.00 42.77           C  \\nANISOU  531  C   VAL B   8     4734   6178   5337    628   -463    403       C  \\nATOM    532  O   VAL B   8      48.075  65.599   7.434  1.00 32.51           O  \\nANISOU  532  O   VAL B   8     3445   4867   4040    584   -398    371       O  \\nATOM    533  CB  VAL B   8      46.473  64.987   4.494  1.00 46.21           C  \\nANISOU  533  CB  VAL B   8     5034   6773   5749    598   -563    398       C  \\nATOM    534  CG1 VAL B   8      46.711  64.391   3.104  1.00 36.97           C  \\nANISOU  534  CG1 VAL B   8     3856   5672   4518    552   -626    401       C  \\nATOM    535  CG2 VAL B   8      45.924  63.937   5.447  1.00 45.60           C  \\nANISOU  535  CG2 VAL B   8     4870   6725   5730    559   -497    340       C  \\nATOM    536  N   PRO B   9      46.908  67.339   6.599  1.00 35.33           N  \\nANISOU  536  N   PRO B   9     3794   5201   4428    726   -484    420       N  \\nATOM    537  CA  PRO B   9      46.730  67.906   7.948  1.00 38.56           C  \\nANISOU  537  CA  PRO B   9     4216   5560   4877    779   -427    383       C  \\nATOM    538  C   PRO B   9      45.725  67.139   8.836  1.00 43.61           C  \\nANISOU  538  C   PRO B   9     4747   6272   5550    793   -371    335       C  \\nATOM    539  O   PRO B   9      45.091  66.197   8.365  1.00 35.25           O  \\nANISOU  539  O   PRO B   9     3596   5294   4504    759   -381    329       O  \\nATOM    540  CB  PRO B   9      46.190  69.324   7.670  1.00 38.79           C  \\nANISOU  540  CB  PRO B   9     4270   5528   4941    888   -470    413       C  \\nATOM    541  CG  PRO B   9      46.454  69.591   6.207  1.00 36.45           C  \\nANISOU  541  CG  PRO B   9     4007   5232   4609    880   -544    486       C  \\nATOM    542  CD  PRO B   9      46.426  68.249   5.541  1.00 31.23           C  \\nANISOU  542  CD  PRO B   9     3282   4678   3906    799   -559    476       C  \\nATOM    543  N   PHE B  10      45.616  67.549  10.103  1.00 35.24           N  \\nANISOU  543  N   PHE B  10     3698   5184   4505    841   -310    297       N  \\nATOM    544  CA  PHE B  10      44.510  67.177  11.023  1.00 42.36           C  \\nANISOU  544  CA  PHE B  10     4499   6152   5443    887   -247    261       C  \\nATOM    545  C   PHE B  10      44.433  65.739  11.570  1.00 43.46           C  \\nANISOU  545  C   PHE B  10     4573   6361   5578    810   -176    252       C  \\nATOM    546  O   PHE B  10      44.309  65.539  12.782  1.00 46.87           O  \\nANISOU  546  O   PHE B  10     4992   6813   6003    829    -95    229       O  \\nATOM    547  CB  PHE B  10      43.151  67.557  10.432  1.00 47.01           C  \\nANISOU  547  CB  PHE B  10     4988   6789   6087    967   -290    268       C  \\nATOM    548  CG  PHE B  10      42.002  67.337  11.373  1.00 45.93           C  \\nANISOU  548  CG  PHE B  10     4740   6718   5993   1022   -220    232       C  \\nATOM    549  CD1 PHE B  10      41.794  68.197  12.442  1.00 52.33           C  \\nANISOU  549  CD1 PHE B  10     5575   7498   6809   1115   -170    196       C  \\nATOM    550  CD2 PHE B  10      41.132  66.268  11.191  1.00 49.66           C  \\nANISOU  550  CD2 PHE B  10     5080   7286   6505    979   -200    229       C  \\nATOM    551  CE1 PHE B  10      40.742  67.996  13.317  1.00 53.96           C  \\nANISOU  551  CE1 PHE B  10     5677   7779   7048   1170    -95    165       C  \\nATOM    552  CE2 PHE B  10      40.067  66.060  12.063  1.00 52.27           C  \\nANISOU  552  CE2 PHE B  10     5298   7681   6881   1024   -124    203       C  \\nATOM    553  CZ  PHE B  10      39.872  66.926  13.124  1.00 54.36           C  \\nANISOU  553  CZ  PHE B  10     5588   7926   7139   1123    -68    175       C  \\nATOM    554  N   LEU B  11      44.448  64.755  10.674  1.00 37.59           N  \\nANISOU  554  N   LEU B  11     3786   5655   4842    729   -205    269       N  \\nATOM    555  CA  LEU B  11      44.377  63.346  11.057  1.00 39.03           C  \\nANISOU  555  CA  LEU B  11     3908   5882   5041    649   -140    265       C  \\nATOM    556  C   LEU B  11      45.374  62.988  12.160  1.00 45.36           C  \\nANISOU  556  C   LEU B  11     4785   6654   5794    620    -66    269       C  \\nATOM    557  O   LEU B  11      46.527  63.435  12.154  1.00 43.70           O  \\nANISOU  557  O   LEU B  11     4682   6390   5531    609    -90    272       O  \\nATOM    558  CB  LEU B  11      44.622  62.459   9.830  1.00 33.74           C  \\nANISOU  558  CB  LEU B  11     3216   5227   4375    561   -195    269       C  \\nATOM    559  CG  LEU B  11      43.399  61.860   9.122  1.00 50.01           C  \\nANISOU  559  CG  LEU B  11     5139   7359   6502    544   -225    247       C  \\nATOM    560  CD1 LEU B  11      42.155  62.678   9.410  1.00 38.31           C  \\nANISOU  560  CD1 LEU B  11     3574   5918   5064    643   -228    239       C  \\nATOM    561  CD2 LEU B  11      43.633  61.731   7.615  1.00 43.45           C  \\nANISOU  561  CD2 LEU B  11     4316   6548   5646    509   -326    242       C  \\nATOM    562  N   SER B  12      44.933  62.176  13.109  1.00 36.13           N  \\nANISOU  562  N   SER B  12     3558   5526   4645    609     26    273       N  \\nATOM    563  CA  SER B  12      45.831  61.750  14.169  1.00 32.40           C  \\nANISOU  563  CA  SER B  12     3151   5043   4116    592     95    287       C  \\nATOM    564  C   SER B  12      45.447  60.393  14.723  1.00 35.10           C  \\nANISOU  564  C   SER B  12     3422   5422   4493    541    188    319       C  \\nATOM    565  O   SER B  12      44.368  59.862  14.437  1.00 32.94           O  \\nANISOU  565  O   SER B  12     3036   5182   4298    519    209    321       O  \\nATOM    566  CB  SER B  12      45.850  62.779  15.306  1.00 29.68           C  \\nANISOU  566  CB  SER B  12     2853   4702   3722    686    129    261       C  \\nATOM    567  OG  SER B  12      44.574  62.855  15.927  1.00 36.50           O  \\nANISOU  567  OG  SER B  12     3621   5624   4623    747    192    253       O  \\nATOM    568  N   LYS B  13      46.349  59.844  15.526  1.00 25.92           N  \\nANISOU  568  N   LYS B  13     2322   4251   3275    522    243    346       N  \\nATOM    569  CA  LYS B  13      46.098  58.615  16.247  1.00 32.20           C  \\nANISOU  569  CA  LYS B  13     3068   5071   4095    487    346    396       C  \\nATOM    570  C   LYS B  13      46.627  58.796  17.647  1.00 42.99           C  \\nANISOU  570  C   LYS B  13     4498   6469   5368    548    415    417       C  \\nATOM    571  O   LYS B  13      47.476  59.662  17.903  1.00 38.02           O  \\nANISOU  571  O   LYS B  13     3958   5829   4658    591    368    383       O  \\nATOM    572  CB  LYS B  13      46.836  57.446  15.594  1.00 24.48           C  \\nANISOU  572  CB  LYS B  13     2108   4045   3147    393    335    420       C  \\nATOM    573  CG  LYS B  13      48.359  57.525  15.725  1.00 40.69           C  \\nANISOU  573  CG  LYS B  13     4278   6067   5114    390    304    426       C  \\nATOM    574  CD  LYS B  13      49.042  56.309  15.107  1.00 50.21           C  \\nANISOU  574  CD  LYS B  13     5494   7227   6355    307    302    448       C  \\nATOM    575  CE  LYS B  13      48.585  55.017  15.774  1.00 53.98           C  \\nANISOU  575  CE  LYS B  13     5916   7701   6892    277    411    508       C  \\nATOM    576  NZ  LYS B  13      49.261  53.827  15.196  1.00 64.66           N  \\nANISOU  576  NZ  LYS B  13     7283   8993   8292    204    412    524       N  \\nATOM    577  N   THR B  14      46.117  57.977  18.557  1.00 43.69           N  \\nANISOU  577  N   THR B  14     4535   6599   5466    552    528    472       N  \\nATOM    578  CA  THR B  14      46.685  57.880  19.882  1.00 24.66           C  \\nANISOU  578  CA  THR B  14     2184   4234   2952    607    600    508       C  \\nATOM    579  C   THR B  14      47.843  56.892  19.801  1.00 29.15           C  \\nANISOU  579  C   THR B  14     2814   4762   3501    550    599    558       C  \\nATOM    580  O   THR B  14      47.685  55.780  19.291  1.00 28.26           O  \\nANISOU  580  O   THR B  14     2658   4606   3476    473    627    603       O  \\nATOM    581  CB  THR B  14      45.639  57.365  20.897  1.00 44.50           C  \\nANISOU  581  CB  THR B  14     4616   6816   5477    639    735    567       C  \\nATOM    582  OG1 THR B  14      44.578  58.325  21.021  1.00 30.50           O  \\nANISOU  582  OG1 THR B  14     2780   5090   3718    705    739    514       O  \\nATOM    583  CG2 THR B  14      46.290  57.106  22.286  1.00 35.29           C  \\nANISOU  583  CG2 THR B  14     3515   5710   4182    700    815    621       C  \\nATOM    584  N   CYS B  15      49.006  57.298  20.296  1.00 23.62           N  \\nANISOU  584  N   CYS B  15     2209   4073   2693    589    564    544       N  \\nATOM    585  CA  CYS B  15      50.177  56.434  20.309  1.00 33.14           C  \\nANISOU  585  CA  CYS B  15     3471   5251   3870    553    560    590       C  \\nATOM    586  C   CYS B  15      50.013  55.204  21.203  1.00 37.59           C  \\nANISOU  586  C   CYS B  15     4014   5840   4430    559    680    696       C  \\nATOM    587  O   CYS B  15      49.482  55.283  22.315  1.00 30.37           O  \\nANISOU  587  O   CYS B  15     3083   5000   3455    625    765    732       O  \\nATOM    588  CB  CYS B  15      51.403  57.215  20.769  1.00 41.20           C  \\nANISOU  588  CB  CYS B  15     4584   6298   4774    601    497    544       C  \\nATOM    589  SG  CYS B  15      51.716  58.681  19.805  1.00 43.73           S  \\nANISOU  589  SG  CYS B  15     4940   6571   5106    592    370    436       S  \\nATOM    590  N   PRO B  16      50.504  54.065  20.718  1.00 37.18           N  \\nANISOU  590  N   PRO B  16     3965   5723   4439    493    690    748       N  \\nATOM    591  CA  PRO B  16      50.578  52.819  21.485  1.00 24.44           C  \\nANISOU  591  CA  PRO B  16     2348   4107   2831    497    799    863       C  \\nATOM    592  C   PRO B  16      51.488  52.988  22.704  1.00 40.25           C  \\nANISOU  592  C   PRO B  16     4426   6190   4676    590    816    902       C  \\nATOM    593  O   PRO B  16      52.335  53.891  22.726  1.00 24.12           O  \\nANISOU  593  O   PRO B  16     2442   4180   2541    626    726    827       O  \\nATOM    594  CB  PRO B  16      51.251  51.846  20.506  1.00 33.38           C  \\nANISOU  594  CB  PRO B  16     3492   5138   4052    417    765    873       C  \\nATOM    595  CG  PRO B  16      51.221  52.524  19.165  1.00 41.57           C  \\nANISOU  595  CG  PRO B  16     4516   6137   5140    362    652    765       C  \\nATOM    596  CD  PRO B  16      51.203  53.980  19.423  1.00 22.68           C  \\nANISOU  596  CD  PRO B  16     2151   3812   2656    424    593    697       C  \\nATOM    597  N   GLU B  17      51.314  52.126  23.704  1.00 31.77           N  \\nANISOU  597  N   GLU B  17     3348   5149   3572    628    932   1020       N  \\nATOM    598  CA  GLU B  17      52.196  52.116  24.866  1.00 46.70           C  \\nANISOU  598  CA  GLU B  17     5309   7130   5306    723    949   1071       C  \\nATOM    599  C   GLU B  17      53.632  51.994  24.396  1.00 39.44           C  \\nANISOU  599  C   GLU B  17     4452   6174   4359    713    850   1041       C  \\nATOM    600  O   GLU B  17      53.918  51.241  23.473  1.00 38.84           O  \\nANISOU  600  O   GLU B  17     4367   5995   4394    638    832   1054       O  \\nATOM    601  CB  GLU B  17      51.862  50.943  25.790  1.00 28.10           C  \\nANISOU  601  CB  GLU B  17     2941   4792   2945    754   1093   1231       C  \\nATOM    602  CG  GLU B  17      50.459  51.009  26.337  1.00 46.85           C  \\nANISOU  602  CG  GLU B  17     5244   7214   5344    765   1209   1273       C  \\nATOM    603  CD  GLU B  17      50.151  49.889  27.300  1.00 60.26           C  \\nANISOU  603  CD  GLU B  17     6933   8932   7032    797   1364   1447       C  \\nATOM    604  OE1 GLU B  17      48.957  49.580  27.457  1.00 61.25           O  \\nANISOU  604  OE1 GLU B  17     6979   9052   7242    765   1476   1502       O  \\nATOM    605  OE2 GLU B  17      51.090  49.332  27.910  1.00 57.16           O  \\nANISOU  605  OE2 GLU B  17     6608   8563   6548    856   1377   1535       O  \\nATOM    606  N   GLY B  18      54.529  52.754  25.012  1.00 38.06           N  \\nANISOU  606  N   GLY B  18     4334   6088   4039    785    785    990       N  \\nATOM    607  CA  GLY B  18      55.937  52.674  24.675  1.00 37.88           C  \\nANISOU  607  CA  GLY B  18     4360   6050   3984    781    694    962       C  \\nATOM    608  C   GLY B  18      56.393  53.774  23.737  1.00 42.08           C  \\nANISOU  608  C   GLY B  18     4902   6549   4537    733    570    823       C  \\nATOM    609  O   GLY B  18      57.556  54.144  23.749  1.00 39.68           O  \\nANISOU  609  O   GLY B  18     4636   6272   4169    748    490    774       O  \\nATOM    610  N   LYS B  19      55.480  54.300  22.926  1.00 46.31           N  \\nANISOU  610  N   LYS B  19     5401   7030   5167    675    557    766       N  \\nATOM    611  CA  LYS B  19      55.810  55.400  22.022  1.00 38.96           C  \\nANISOU  611  CA  LYS B  19     4482   6063   4257    634    449    651       C  \\nATOM    612  C   LYS B  19      55.288  56.737  22.557  1.00 34.42           C  \\nANISOU  612  C   LYS B  19     3912   5542   3622    687    428    569       C  \\nATOM    613  O   LYS B  19      54.135  57.099  22.348  1.00 44.24           O  \\nANISOU  613  O   LYS B  19     5115   6771   4921    682    456    554       O  \\nATOM    614  CB  LYS B  19      55.267  55.130  20.614  1.00 34.11           C  \\nANISOU  614  CB  LYS B  19     3827   5350   3782    542    431    639       C  \\nATOM    615  CG  LYS B  19      55.632  53.760  20.055  1.00 23.36           C  \\nANISOU  615  CG  LYS B  19     2456   3924   2496    490    460    705       C  \\nATOM    616  CD  LYS B  19      55.196  53.608  18.598  1.00 32.98           C  \\nANISOU  616  CD  LYS B  19     3637   5060   3833    402    423    665       C  \\nATOM    617  CE  LYS B  19      55.618  52.260  18.023  1.00 44.64           C  \\nANISOU  617  CE  LYS B  19     5107   6467   5388    352    448    708       C  \\nATOM    618  NZ  LYS B  19      55.379  52.163  16.545  1.00 46.57           N  \\nANISOU  618  NZ  LYS B  19     5323   6648   5725    271    396    648       N  \\nATOM    619  N   ASN B  20      56.155  57.469  23.242  1.00 40.14           N  \\nANISOU  619  N   ASN B  20     4683   6329   4238    738    375    508       N  \\nATOM    620  CA  ASN B  20      55.787  58.744  23.842  1.00 37.88           C  \\nANISOU  620  CA  ASN B  20     4410   6090   3892    795    352    414       C  \\nATOM    621  C   ASN B  20      56.423  59.953  23.140  1.00 44.96           C  \\nANISOU  621  C   ASN B  20     5336   6928   4818    757    243    301       C  \\nATOM    622  O   ASN B  20      56.601  61.011  23.753  1.00 24.87           O  \\nANISOU  622  O   ASN B  20     2819   4419   2212    804    204    206       O  \\nATOM    623  CB  ASN B  20      56.162  58.756  25.323  1.00 42.17           C  \\nANISOU  623  CB  ASN B  20     4981   6760   4281    893    380    414       C  \\nATOM    624  CG  ASN B  20      55.558  57.584  26.095  1.00 51.62           C  \\nANISOU  624  CG  ASN B  20     6154   8019   5440    939    501    546       C  \\nATOM    625  OD1 ASN B  20      54.336  57.385  26.121  1.00 44.42           O  \\nANISOU  625  OD1 ASN B  20     5198   7100   4581    941    585    589       O  \\nATOM    626  ND2 ASN B  20      56.423  56.805  26.737  1.00 49.55           N  \\nANISOU  626  ND2 ASN B  20     5918   7818   5090    978    514    615       N  \\nATOM    627  N   LEU B  21      56.776  59.785  21.865  1.00 34.96           N  \\nANISOU  627  N   LEU B  21     4066   5573   3646    672    197    311       N  \\nATOM    628  CA  LEU B  21      57.212  60.911  21.033  1.00 43.83           C  \\nANISOU  628  CA  LEU B  21     5212   6626   4815    627    109    227       C  \\nATOM    629  C   LEU B  21      56.448  60.960  19.711  1.00 40.10           C  \\nANISOU  629  C   LEU B  21     4712   6069   4455    568    100    248       C  \\nATOM    630  O   LEU B  21      56.188  59.920  19.091  1.00 43.20           O  \\nANISOU  630  O   LEU B  21     5073   6442   4899    526    132    316       O  \\nATOM    631  CB  LEU B  21      58.713  60.841  20.737  1.00 23.93           C  \\nANISOU  631  CB  LEU B  21     2718   4099   2276    582     46    209       C  \\nATOM    632  CG  LEU B  21      59.699  61.019  21.880  1.00 44.84           C  \\nANISOU  632  CG  LEU B  21     5389   6833   4815    633     20    163       C  \\nATOM    633  CD1 LEU B  21      61.092  60.717  21.366  1.00 36.09           C  \\nANISOU  633  CD1 LEU B  21     4284   5714   3713    578    -34    163       C  \\nATOM    634  CD2 LEU B  21      59.612  62.428  22.460  1.00 41.80           C  \\nANISOU  634  CD2 LEU B  21     5028   6455   4399    669    -23     45       C  \\nATOM    635  N   CYS B  22      56.092  62.169  19.283  1.00 32.48           N  \\nANISOU  635  N   CYS B  22     3759   5053   3529    570     55    186       N  \\nATOM    636  CA  CYS B  22      55.630  62.393  17.916  1.00 20.28           C  \\nANISOU  636  CA  CYS B  22     2198   3434   2075    517     23    201       C  \\nATOM    637  C   CYS B  22      56.871  62.638  17.044  1.00 36.67           C  \\nANISOU  637  C   CYS B  22     4309   5460   4164    449    -42    190       C  \\nATOM    638  O   CYS B  22      57.883  63.171  17.523  1.00 33.76           O  \\nANISOU  638  O   CYS B  22     3976   5096   3754    449    -76    142       O  \\nATOM    639  CB  CYS B  22      54.696  63.603  17.847  1.00 20.79           C  \\nANISOU  639  CB  CYS B  22     2261   3462   2176    563      6    154       C  \\nATOM    640  SG  CYS B  22      53.162  63.502  18.828  1.00 23.93           S  \\nANISOU  640  SG  CYS B  22     2604   3924   2564    650     87    157       S  \\nATOM    641  N   TYR B  23      56.810  62.234  15.781  1.00 31.06           N  \\nANISOU  641  N   TYR B  23     3582   4711   3506    391    -59    230       N  \\nATOM    642  CA  TYR B  23      57.896  62.539  14.859  1.00 37.83           C  \\nANISOU  642  CA  TYR B  23     4470   5528   4375    329   -111    225       C  \\nATOM    643  C   TYR B  23      57.350  63.094  13.556  1.00 39.21           C  \\nANISOU  643  C   TYR B  23     4643   5649   4606    303   -146    242       C  \\nATOM    644  O   TYR B  23      56.216  62.800  13.176  1.00 33.59           O  \\nANISOU  644  O   TYR B  23     3893   4944   3926    319   -133    265       O  \\nATOM    645  CB  TYR B  23      58.782  61.315  14.590  1.00 24.94           C  \\nANISOU  645  CB  TYR B  23     2826   3923   2725    285    -97    261       C  \\nATOM    646  CG  TYR B  23      58.169  60.299  13.640  1.00 35.57           C  \\nANISOU  646  CG  TYR B  23     4136   5263   4115    253    -77    305       C  \\nATOM    647  CD1 TYR B  23      57.345  59.287  14.113  1.00 35.66           C  \\nANISOU  647  CD1 TYR B  23     4108   5299   4141    274    -19    336       C  \\nATOM    648  CD2 TYR B  23      58.422  60.351  12.276  1.00 23.39           C  \\nANISOU  648  CD2 TYR B  23     2596   3692   2598    200   -113    313       C  \\nATOM    649  CE1 TYR B  23      56.785  58.358  13.253  1.00 41.81           C  \\nANISOU  649  CE1 TYR B  23     4847   6065   4974    236     -5    360       C  \\nATOM    650  CE2 TYR B  23      57.869  59.427  11.408  1.00 41.14           C  \\nANISOU  650  CE2 TYR B  23     4808   5943   4880    172   -102    333       C  \\nATOM    651  CZ  TYR B  23      57.048  58.434  11.906  1.00 47.52           C  \\nANISOU  651  CZ  TYR B  23     5574   6766   5716    187    -51    349       C  \\nATOM    652  OH  TYR B  23      56.483  57.510  11.064  1.00 48.05           O  \\nANISOU  652  OH  TYR B  23     5598   6827   5830    151    -43    354       O  \\nATOM    653  N   LYS B  24      58.167  63.907  12.890  1.00 35.17           N  \\nANISOU  653  N   LYS B  24     4168   5089   4104    264   -191    234       N  \\nATOM    654  CA  LYS B  24      57.860  64.412  11.561  1.00 34.09           C  \\nANISOU  654  CA  LYS B  24     4039   4909   4004    240   -224    267       C  \\nATOM    655  C   LYS B  24      59.108  64.347  10.707  1.00 36.59           C  \\nANISOU  655  C   LYS B  24     4378   5215   4311    170   -243    286       C  \\nATOM    656  O   LYS B  24      60.148  64.886  11.082  1.00 39.69           O  \\nANISOU  656  O   LYS B  24     4796   5586   4698    145   -253    260       O  \\nATOM    657  CB  LYS B  24      57.357  65.858  11.601  1.00 23.39           C  \\nANISOU  657  CB  LYS B  24     2715   3487   2687    280   -251    250       C  \\nATOM    658  CG  LYS B  24      57.154  66.458  10.189  1.00 35.02           C  \\nANISOU  658  CG  LYS B  24     4203   4913   4188    263   -287    303       C  \\nATOM    659  CD  LYS B  24      56.405  67.808  10.188  1.00 24.08           C  \\nANISOU  659  CD  LYS B  24     2843   3452   2852    322   -310    301       C  \\nATOM    660  CE  LYS B  24      57.235  68.914  10.834  1.00 33.48           C  \\nANISOU  660  CE  LYS B  24     4088   4562   4072    312   -318    254       C  \\nATOM    661  NZ  LYS B  24      56.538  70.244  10.801  1.00 28.39           N  \\nANISOU  661  NZ  LYS B  24     3475   3822   3490    373   -337    251       N  \\nATOM    662  N   MET B  25      59.007  63.684   9.559  1.00 30.97           N  \\nANISOU  662  N   MET B  25     3647   4525   3594    139   -247    325       N  \\nATOM    663  CA  MET B  25      60.099  63.666   8.595  1.00 23.98           C  \\nANISOU  663  CA  MET B  25     2779   3639   2693     79   -258    349       C  \\nATOM    664  C   MET B  25      59.827  64.640   7.476  1.00 24.71           C  \\nANISOU  664  C   MET B  25     2898   3692   2798     74   -289    392       C  \\nATOM    665  O   MET B  25      58.715  64.708   6.961  1.00 36.19           O  \\nANISOU  665  O   MET B  25     4339   5154   4259    109   -306    413       O  \\nATOM    666  CB  MET B  25      60.282  62.271   8.012  1.00 19.69           C  \\nANISOU  666  CB  MET B  25     2204   3153   2127     52   -240    357       C  \\nATOM    667  CG  MET B  25      60.733  61.255   9.032  1.00 38.09           C  \\nANISOU  667  CG  MET B  25     4512   5512   4446     58   -205    333       C  \\nATOM    668  SD  MET B  25      61.211  59.709   8.266  1.00 59.62           S  \\nANISOU  668  SD  MET B  25     7211   8280   7163     25   -182    337       S  \\nATOM    669  CE  MET B  25      61.530  58.717   9.720  1.00 47.97           C  \\nANISOU  669  CE  MET B  25     5719   6822   5686     56   -138    329       C  \\nATOM    670  N   THR B  26      60.848  65.399   7.102  1.00 35.52           N  \\nANISOU  670  N   THR B  26     4301   5022   4171     30   -294    411       N  \\nATOM    671  CA  THR B  26      60.772  66.274   5.932  1.00 37.31           C  \\nANISOU  671  CA  THR B  26     4560   5213   4404     20   -313    476       C  \\nATOM    672  C   THR B  26      62.011  66.048   5.075  1.00 31.07           C  \\nANISOU  672  C   THR B  26     3774   4449   3581    -48   -296    507       C  \\nATOM    673  O   THR B  26      63.033  65.560   5.569  1.00 29.70           O  \\nANISOU  673  O   THR B  26     3583   4299   3403    -87   -275    471       O  \\nATOM    674  CB  THR B  26      60.754  67.763   6.365  1.00 39.65           C  \\nANISOU  674  CB  THR B  26     4900   5404   4760     34   -325    479       C  \\nATOM    675  OG1 THR B  26      61.861  68.012   7.249  1.00 32.85           O  \\nANISOU  675  OG1 THR B  26     4044   4514   3923     -9   -312    426       O  \\nATOM    676  CG2 THR B  26      59.444  68.102   7.084  1.00 26.33           C  \\nANISOU  676  CG2 THR B  26     3209   3693   3104    115   -339    450       C  \\nATOM    677  N   LEU B  27      61.936  66.385   3.795  1.00 26.34           N  \\nANISOU  677  N   LEU B  27     3194   3858   2955    -56   -302    577       N  \\nATOM    678  CA  LEU B  27      63.158  66.530   2.996  1.00 37.00           C  \\nANISOU  678  CA  LEU B  27     4555   5221   4281   -120   -276    620       C  \\nATOM    679  C   LEU B  27      63.877  67.790   3.443  1.00 40.31           C  \\nANISOU  679  C   LEU B  27     5006   5540   4771   -158   -266    635       C  \\nATOM    680  O   LEU B  27      63.245  68.836   3.596  1.00 36.30           O  \\nANISOU  680  O   LEU B  27     4534   4946   4313   -126   -283    660       O  \\nATOM    681  CB  LEU B  27      62.837  66.660   1.515  1.00 26.87           C  \\nANISOU  681  CB  LEU B  27     3290   3981   2938   -109   -282    701       C  \\nATOM    682  CG  LEU B  27      62.205  65.449   0.831  1.00 35.98           C  \\nANISOU  682  CG  LEU B  27     4409   5241   4020    -81   -298    677       C  \\nATOM    683  CD1 LEU B  27      62.057  65.742  -0.655  1.00 27.51           C  \\nANISOU  683  CD1 LEU B  27     3359   4222   2871    -70   -307    758       C  \\nATOM    684  CD2 LEU B  27      63.045  64.200   1.056  1.00 24.99           C  \\nANISOU  684  CD2 LEU B  27     2979   3909   2608   -120   -267    612       C  \\nATOM    685  N   MET B  28      65.186  67.695   3.658  1.00 41.15           N  \\nANISOU  685  N   MET B  28     5093   5653   4888   -225   -238    613       N  \\nATOM    686  CA  MET B  28      65.964  68.837   4.147  1.00 40.10           C  \\nANISOU  686  CA  MET B  28     4976   5424   4836   -277   -230    608       C  \\nATOM    687  C   MET B  28      65.748  70.091   3.292  1.00 42.81           C  \\nANISOU  687  C   MET B  28     5373   5675   5219   -286   -222    707       C  \\nATOM    688  O   MET B  28      65.691  71.207   3.808  1.00 42.45           O  \\nANISOU  688  O   MET B  28     5357   5510   5261   -292   -230    699       O  \\nATOM    689  CB  MET B  28      67.453  68.480   4.254  1.00 39.61           C  \\nANISOU  689  CB  MET B  28     4870   5404   4776   -354   -201    579       C  \\nATOM    690  CG  MET B  28      67.780  67.628   5.476  1.00 52.21           C  \\nANISOU  690  CG  MET B  28     6421   7054   6362   -339   -216    477       C  \\nATOM    691  SD  MET B  28      69.529  67.552   5.892  1.00101.23           S  \\nANISOU  691  SD  MET B  28    12569  13295  12597   -420   -199    429       S  \\nATOM    692  CE  MET B  28      69.472  66.801   7.525  1.00 45.54           C  \\nANISOU  692  CE  MET B  28     5485   6293   5526   -365   -235    319       C  \\nATOM    693  N   LYS B  29      65.577  69.897   1.991  1.00 33.96           N  \\nANISOU  693  N   LYS B  29     4264   4608   4031   -278   -206    799       N  \\nATOM    694  CA  LYS B  29      65.377  71.016   1.079  1.00 59.92           C  \\nANISOU  694  CA  LYS B  29     7605   7822   7341   -276   -193    917       C  \\nATOM    695  C   LYS B  29      63.937  71.560   1.051  1.00 61.95           C  \\nANISOU  695  C   LYS B  29     7902   8027   7610   -182   -237    949       C  \\nATOM    696  O   LYS B  29      63.697  72.669   0.564  1.00 68.42           O  \\nANISOU  696  O   LYS B  29     8772   8751   8473   -166   -232   1043       O  \\nATOM    697  CB  LYS B  29      65.862  70.642  -0.330  1.00 69.78           C  \\nANISOU  697  CB  LYS B  29     8852   9166   8496   -300   -156   1011       C  \\nATOM    698  CG  LYS B  29      67.390  70.583  -0.443  1.00 75.56           C  \\nANISOU  698  CG  LYS B  29     9550   9914   9244   -400    -97   1012       C  \\nATOM    699  CD  LYS B  29      67.862  70.105  -1.817  1.00 85.82           C  \\nANISOU  699  CD  LYS B  29    10843  11329  10435   -414    -52   1094       C  \\nATOM    700  CE  LYS B  29      69.376  70.263  -1.966  1.00 91.49           C  \\nANISOU  700  CE  LYS B  29    11523  12053  11186   -515     17   1112       C  \\nATOM    701  NZ  LYS B  29      69.901  69.602  -3.197  1.00 92.52           N  \\nANISOU  701  NZ  LYS B  29    11635  12321  11199   -523     68   1168       N  \\nATOM    702  N   MET B  30      62.989  70.789   1.586  1.00 54.77           N  \\nANISOU  702  N   MET B  30     6965   7177   6670   -118   -276    875       N  \\nATOM    703  CA  MET B  30      61.578  71.186   1.599  1.00 39.85           C  \\nANISOU  703  CA  MET B  30     5093   5259   4791    -23   -318    893       C  \\nATOM    704  C   MET B  30      60.970  71.027   2.986  1.00 36.15           C  \\nANISOU  704  C   MET B  30     4602   4764   4372     16   -338    782       C  \\nATOM    705  O   MET B  30      60.201  70.092   3.219  1.00 35.16           O  \\nANISOU  705  O   MET B  30     4433   4722   4202     58   -357    734       O  \\nATOM    706  CB  MET B  30      60.781  70.311   0.632  1.00 49.71           C  \\nANISOU  706  CB  MET B  30     6316   6636   5935     26   -344    922       C  \\nATOM    707  CG  MET B  30      61.366  70.197  -0.771  1.00 40.48           C  \\nANISOU  707  CG  MET B  30     5163   5539   4681     -3   -323   1017       C  \\nATOM    708  SD  MET B  30      60.807  71.567  -1.791  1.00217.11           S  \\nANISOU  708  SD  MET B  30    27598  27842  27051     57   -335   1174       S  \\nATOM    709  CE  MET B  30      59.041  71.415  -1.551  1.00129.03           C  \\nANISOU  709  CE  MET B  30    16416  16718  15892    176   -409   1136       C  \\nATOM    710  N   PRO B  31      61.303  71.937   3.917  1.00 36.95           N  \\nANISOU  710  N   PRO B  31     4727   4748   4564      1   -332    739       N  \\nATOM    711  CA  PRO B  31      60.835  71.809   5.306  1.00 39.89           C  \\nANISOU  711  CA  PRO B  31     5079   5108   4969     40   -346    627       C  \\nATOM    712  C   PRO B  31      59.316  71.926   5.475  1.00 41.51           C  \\nANISOU  712  C   PRO B  31     5278   5315   5178    145   -374    623       C  \\nATOM    713  O   PRO B  31      58.790  71.506   6.511  1.00 53.11           O  \\nANISOU  713  O   PRO B  31     6717   6816   6647    184   -377    539       O  \\nATOM    714  CB  PRO B  31      61.549  72.964   6.035  1.00 34.21           C  \\nANISOU  714  CB  PRO B  31     4395   4255   4347      1   -338    584       C  \\nATOM    715  CG  PRO B  31      61.894  73.947   4.952  1.00 36.18           C  \\nANISOU  715  CG  PRO B  31     4693   4410   4643    -31   -323    699       C  \\nATOM    716  CD  PRO B  31      62.168  73.116   3.722  1.00 40.59           C  \\nANISOU  716  CD  PRO B  31     5233   5084   5104    -58   -308    787       C  \\nATOM    717  N   LYS B  32      58.630  72.473   4.475  1.00 41.97           N  \\nANISOU  717  N   LYS B  32     5360   5349   5236    194   -392    719       N  \\nATOM    718  CA  LYS B  32      57.190  72.740   4.562  1.00 39.36           C  \\nANISOU  718  CA  LYS B  32     5018   5017   4921    301   -423    722       C  \\nATOM    719  C   LYS B  32      56.307  71.516   4.315  1.00 48.25           C  \\nANISOU  719  C   LYS B  32     6075   6285   5972    335   -442    704       C  \\nATOM    720  O   LYS B  32      55.106  71.555   4.597  1.00 44.27           O  \\nANISOU  720  O   LYS B  32     5538   5799   5485    417   -464    684       O  \\nATOM    721  CB  LYS B  32      56.788  73.842   3.574  1.00 37.77           C  \\nANISOU  721  CB  LYS B  32     4866   4736   4750    352   -442    839       C  \\nATOM    722  CG  LYS B  32      57.331  75.224   3.907  1.00 58.55           C  \\nANISOU  722  CG  LYS B  32     7565   7190   7490    338   -423    855       C  \\nATOM    723  CD  LYS B  32      56.564  75.861   5.055  1.00 58.40           C  \\nANISOU  723  CD  LYS B  32     7548   7086   7554    415   -433    766       C  \\nATOM    724  CE  LYS B  32      57.158  77.212   5.436  1.00 67.42           C  \\nANISOU  724  CE  LYS B  32     8759   8039   8820    393   -416    759       C  \\nATOM    725  NZ  LYS B  32      57.822  77.168   6.774  1.00 72.08           N  \\nANISOU  725  NZ  LYS B  32     9339   8601   9446    340   -401    611       N  \\nATOM    726  N   ILE B  33      56.898  70.447   3.781  1.00 43.46           N  \\nANISOU  726  N   ILE B  33     5443   5776   5293    271   -432    707       N  \\nATOM    727  CA  ILE B  33      56.153  69.237   3.418  1.00 31.18           C  \\nANISOU  727  CA  ILE B  33     3823   4346   3677    289   -450    685       C  \\nATOM    728  C   ILE B  33      56.531  68.018   4.245  1.00 29.22           C  \\nANISOU  728  C   ILE B  33     3532   4155   3415    241   -420    600       C  \\nATOM    729  O   ILE B  33      57.623  67.470   4.084  1.00 42.85           O  \\nANISOU  729  O   ILE B  33     5266   5905   5109    172   -396    594       O  \\nATOM    730  CB  ILE B  33      56.360  68.872   1.937  1.00 32.35           C  \\nANISOU  730  CB  ILE B  33     3973   4573   3746    268   -469    755       C  \\nATOM    731  CG1 ILE B  33      55.931  70.034   1.039  1.00 36.56           C  \\nANISOU  731  CG1 ILE B  33     4550   5063   4278    328   -499    860       C  \\nATOM    732  CG2 ILE B  33      55.592  67.598   1.576  1.00 28.49           C  \\nANISOU  732  CG2 ILE B  33     3412   4207   3205    279   -492    709       C  \\nATOM    733  CD1 ILE B  33      55.927  69.682  -0.414  1.00 30.64           C  \\nANISOU  733  CD1 ILE B  33     3798   4415   3428    330   -525    929       C  \\nATOM    734  N   PRO B  34      55.617  67.576   5.123  1.00 28.14           N  \\nANISOU  734  N   PRO B  34     3347   4042   3302    284   -415    542       N  \\nATOM    735  CA  PRO B  34      55.851  66.345   5.889  1.00 25.72           C  \\nANISOU  735  CA  PRO B  34     3000   3791   2982    249   -381    480       C  \\nATOM    736  C   PRO B  34      55.769  65.171   4.931  1.00 31.99           C  \\nANISOU  736  C   PRO B  34     3753   4671   3730    215   -390    485       C  \\nATOM    737  O   PRO B  34      54.850  65.130   4.112  1.00 34.34           O  \\nANISOU  737  O   PRO B  34     4020   5012   4017    248   -427    505       O  \\nATOM    738  CB  PRO B  34      54.670  66.301   6.881  1.00 22.26           C  \\nANISOU  738  CB  PRO B  34     2517   3359   2582    313   -370    438       C  \\nATOM    739  CG  PRO B  34      53.938  67.620   6.720  1.00 32.74           C  \\nANISOU  739  CG  PRO B  34     3866   4625   3948    385   -401    466       C  \\nATOM    740  CD  PRO B  34      54.266  68.115   5.344  1.00 25.11           C  \\nANISOU  740  CD  PRO B  34     2937   3646   2957    371   -438    541       C  \\nATOM    741  N   ILE B  35      56.723  64.252   4.986  1.00 28.08           N  \\nANISOU  741  N   ILE B  35     3256   4204   3209    155   -361    463       N  \\nATOM    742  CA  ILE B  35      56.669  63.102   4.093  1.00 26.48           C  \\nANISOU  742  CA  ILE B  35     3017   4075   2970    125   -367    451       C  \\nATOM    743  C   ILE B  35      56.242  61.848   4.862  1.00 31.91           C  \\nANISOU  743  C   ILE B  35     3649   4787   3688    118   -335    397       C  \\nATOM    744  O   ILE B  35      55.802  60.856   4.285  1.00 37.07           O  \\nANISOU  744  O   ILE B  35     4257   5489   4339    100   -342    371       O  \\nATOM    745  CB  ILE B  35      58.009  62.890   3.351  1.00 42.43           C  \\nANISOU  745  CB  ILE B  35     5070   6111   4941     69   -355    468       C  \\nATOM    746  CG1 ILE B  35      59.133  62.580   4.335  1.00 18.48           C  \\nANISOU  746  CG1 ILE B  35     2049   3051   1922     34   -312    442       C  \\nATOM    747  CG2 ILE B  35      58.364  64.119   2.492  1.00 27.65           C  \\nANISOU  747  CG2 ILE B  35     3249   4214   3041     72   -377    540       C  \\nATOM    748  CD1 ILE B  35      60.442  62.291   3.687  1.00 22.18           C  \\nANISOU  748  CD1 ILE B  35     2533   3543   2350    -18   -295    452       C  \\nATOM    749  N   LYS B  36      56.362  61.912   6.179  1.00 41.12           N  \\nANISOU  749  N   LYS B  36     4821   5920   4884    131   -299    381       N  \\nATOM    750  CA  LYS B  36      56.011  60.790   7.037  1.00 44.91           C  \\nANISOU  750  CA  LYS B  36     5255   6416   5391    129   -255    351       C  \\nATOM    751  C   LYS B  36      55.882  61.308   8.471  1.00 24.29           C  \\nANISOU  751  C   LYS B  36     2656   3779   2794    171   -225    345       C  \\nATOM    752  O   LYS B  36      56.739  62.044   8.949  1.00 38.05           O  \\nANISOU  752  O   LYS B  36     4447   5492   4519    173   -227    343       O  \\nATOM    753  CB  LYS B  36      57.067  59.678   6.926  1.00 33.91           C  \\nANISOU  753  CB  LYS B  36     3866   5036   3980     81   -227    340       C  \\nATOM    754  CG  LYS B  36      56.769  58.414   7.734  1.00 43.25           C  \\nANISOU  754  CG  LYS B  36     5009   6223   5200     78   -175    324       C  \\nATOM    755  CD  LYS B  36      57.766  57.308   7.424  1.00 32.78           C  \\nANISOU  755  CD  LYS B  36     3687   4902   3866     38   -153    314       C  \\nATOM    756  CE  LYS B  36      57.801  56.254   8.524  1.00 35.64           C  \\nANISOU  756  CE  LYS B  36     4031   5249   4261     48    -92    321       C  \\nATOM    757  NZ  LYS B  36      56.473  55.612   8.753  1.00 30.15           N  \\nANISOU  757  NZ  LYS B  36     3279   4548   3630     50    -64    318       N  \\nATOM    758  N   ARG B  37      54.791  60.942   9.133  1.00 29.04           N  \\nANISOU  758  N   ARG B  37     3208   4397   3430    204   -196    335       N  \\nATOM    759  CA  ARG B  37      54.511  61.384  10.497  1.00 44.80           C  \\nANISOU  759  CA  ARG B  37     5208   6385   5427    255   -161    325       C  \\nATOM    760  C   ARG B  37      53.845  60.278  11.294  1.00 34.33           C  \\nANISOU  760  C   ARG B  37     3826   5092   4125    262    -98    328       C  \\nATOM    761  O   ARG B  37      53.177  59.419  10.732  1.00 47.38           O  \\nANISOU  761  O   ARG B  37     5423   6760   5819    234    -90    332       O  \\nATOM    762  CB  ARG B  37      53.593  62.606  10.498  1.00 33.09           C  \\nANISOU  762  CB  ARG B  37     3723   4884   3966    315   -189    319       C  \\nATOM    763  CG  ARG B  37      54.240  63.857   9.998  1.00 39.22           C  \\nANISOU  763  CG  ARG B  37     4564   5607   4731    318   -237    325       C  \\nATOM    764  CD  ARG B  37      53.434  65.056  10.421  1.00 36.08           C  \\nANISOU  764  CD  ARG B  37     4172   5173   4362    391   -248    311       C  \\nATOM    765  NE  ARG B  37      52.176  65.160   9.700  1.00 31.76           N  \\nANISOU  765  NE  ARG B  37     3572   4647   3847    429   -274    330       N  \\nATOM    766  CZ  ARG B  37      51.453  66.273   9.649  1.00 36.25           C  \\nANISOU  766  CZ  ARG B  37     4146   5180   4448    500   -300    333       C  \\nATOM    767  NH1 ARG B  37      51.871  67.364  10.284  1.00 37.35           N  \\nANISOU  767  NH1 ARG B  37     4346   5249   4598    533   -299    310       N  \\nATOM    768  NH2 ARG B  37      50.313  66.299   8.972  1.00 31.73           N  \\nANISOU  768  NH2 ARG B  37     3513   4641   3901    540   -330    352       N  \\nATOM    769  N   GLY B  38      54.005  60.323  12.609  1.00 32.05           N  \\nANISOU  769  N   GLY B  38     3551   4814   3810    300    -51    326       N  \\nATOM    770  CA  GLY B  38      53.401  59.338  13.476  1.00 33.67           C  \\nANISOU  770  CA  GLY B  38     3710   5051   4032    313     23    348       C  \\nATOM    771  C   GLY B  38      54.015  59.332  14.858  1.00 42.00           C  \\nANISOU  771  C   GLY B  38     4801   6133   5025    355     67    353       C  \\nATOM    772  O   GLY B  38      54.599  60.323  15.301  1.00 35.48           O  \\nANISOU  772  O   GLY B  38     4025   5305   4151    386     36    320       O  \\nATOM    773  N   CYS B  39      53.879  58.200  15.537  1.00 41.27           N  \\nANISOU  773  N   CYS B  39     4682   6064   4935    355    138    396       N  \\nATOM    774  CA  CYS B  39      54.396  58.036  16.881  1.00 32.22           C  \\nANISOU  774  CA  CYS B  39     3565   4961   3716    405    185    415       C  \\nATOM    775  C   CYS B  39      55.683  57.253  16.819  1.00 28.87           C  \\nANISOU  775  C   CYS B  39     3174   4530   3265    377    178    440       C  \\nATOM    776  O   CYS B  39      55.904  56.490  15.885  1.00 34.28           O  \\nANISOU  776  O   CYS B  39     3846   5175   4003    320    169    453       O  \\nATOM    777  CB  CYS B  39      53.400  57.262  17.742  1.00 26.35           C  \\nANISOU  777  CB  CYS B  39     2771   4253   2988    435    281    469       C  \\nATOM    778  SG  CYS B  39      51.783  58.013  17.883  1.00 41.68           S  \\nANISOU  778  SG  CYS B  39     4649   6217   4970    475    306    445       S  \\nATOM    779  N   THR B  40      56.524  57.435  17.833  1.00 38.62           N  \\nANISOU  779  N   THR B  40     4449   5810   4415    424    181    438       N  \\nATOM    780  CA  THR B  40      57.781  56.707  17.936  1.00 34.26           C  \\nANISOU  780  CA  THR B  40     3922   5266   3830    415    174    464       C  \\nATOM    781  C   THR B  40      58.203  56.649  19.404  1.00 49.05           C  \\nANISOU  781  C   THR B  40     5817   7218   5602    492    205    484       C  \\nATOM    782  O   THR B  40      57.747  57.467  20.222  1.00 35.32           O  \\nANISOU  782  O   THR B  40     4085   5526   3807    546    210    449       O  \\nATOM    783  CB  THR B  40      58.880  57.382  17.097  1.00 37.31           C  \\nANISOU  783  CB  THR B  40     4336   5627   4212    371     91    409       C  \\nATOM    784  OG1 THR B  40      60.044  56.547  17.058  1.00 37.42           O  \\nANISOU  784  OG1 THR B  40     4359   5650   4208    361     89    435       O  \\nATOM    785  CG2 THR B  40      59.237  58.760  17.679  1.00 34.70           C  \\nANISOU  785  CG2 THR B  40     4038   5323   3824    403     42    340       C  \\nATOM    786  N   ASP B  41      59.055  55.683  19.745  1.00 43.03           N  \\nANISOU  786  N   ASP B  41     5065   6475   4811    507    225    537       N  \\nATOM    787  CA  ASP B  41      59.594  55.629  21.105  1.00 42.89           C  \\nANISOU  787  CA  ASP B  41     5069   6549   4678    589    241    559       C  \\nATOM    788  C   ASP B  41      60.924  56.372  21.224  1.00 41.54           C  \\nANISOU  788  C   ASP B  41     4923   6419   4441    596    152    484       C  \\nATOM    789  O   ASP B  41      61.079  57.262  22.062  1.00 47.34           O  \\nANISOU  789  O   ASP B  41     5675   7221   5092    644    121    422       O  \\nATOM    790  CB  ASP B  41      59.667  54.194  21.662  1.00 36.98           C  \\nANISOU  790  CB  ASP B  41     4315   5813   3923    626    320    675       C  \\nATOM    791  CG  ASP B  41      60.650  53.305  20.929  1.00 80.83           C  \\nANISOU  791  CG  ASP B  41     9869  11314   9527    590    300    702       C  \\nATOM    792  OD1 ASP B  41      61.376  52.569  21.631  1.00101.38           O  \\nANISOU  792  OD1 ASP B  41    12486  13960  12074    649    321    768       O  \\nATOM    793  OD2 ASP B  41      60.689  53.306  19.671  1.00 77.77           O  \\nANISOU  793  OD2 ASP B  41     9469  10850   9229    512    267    663       O  \\nATOM    794  N   ALA B  42      61.878  56.029  20.372  1.00 35.31           N  \\nANISOU  794  N   ALA B  42     4131   5591   3693    545    112    480       N  \\nATOM    795  CA  ALA B  42      63.118  56.792  20.294  1.00 44.38           C  \\nANISOU  795  CA  ALA B  42     5288   6768   4805    531     29    404       C  \\nATOM    796  C   ALA B  42      63.111  57.601  18.994  1.00 43.68           C  \\nANISOU  796  C   ALA B  42     5198   6599   4797    444    -18    346       C  \\nATOM    797  O   ALA B  42      62.655  57.111  17.961  1.00 26.34           O  \\nANISOU  797  O   ALA B  42     2992   4338   2679    395      4    378       O  \\nATOM    798  CB  ALA B  42      64.322  55.861  20.371  1.00 23.86           C  \\nANISOU  798  CB  ALA B  42     2680   4203   2183    549     21    445       C  \\nATOM    799  N   CYS B  43      63.580  58.844  19.057  1.00 47.72           N  \\nANISOU  799  N   CYS B  43     5722   7117   5292    427    -80    261       N  \\nATOM    800  CA  CYS B  43      63.578  59.715  17.881  1.00 43.35           C  \\nANISOU  800  CA  CYS B  43     5174   6486   4812    351   -119    221       C  \\nATOM    801  C   CYS B  43      64.487  59.185  16.782  1.00 43.38           C  \\nANISOU  801  C   CYS B  43     5162   6463   4857    290   -132    243       C  \\nATOM    802  O   CYS B  43      65.691  58.984  17.003  1.00 41.61           O  \\nANISOU  802  O   CYS B  43     4923   6283   4603    289   -158    229       O  \\nATOM    803  CB  CYS B  43      64.020  61.137  18.240  1.00 27.06           C  \\nANISOU  803  CB  CYS B  43     3128   4420   2734    343   -178    127       C  \\nATOM    804  SG  CYS B  43      63.674  62.341  16.937  1.00 30.45           S  \\nANISOU  804  SG  CYS B  43     3575   4737   3258    268   -208    101       S  \\nATOM    805  N   PRO B  44      63.918  58.963  15.589  1.00 46.27           N  \\nANISOU  805  N   PRO B  44     5525   6768   5286    242   -117    272       N  \\nATOM    806  CA  PRO B  44      64.705  58.491  14.439  1.00 44.41           C  \\nANISOU  806  CA  PRO B  44     5276   6514   5084    187   -124    286       C  \\nATOM    807  C   PRO B  44      65.811  59.479  14.055  1.00 39.71           C  \\nANISOU  807  C   PRO B  44     4681   5916   4490    137   -174    240       C  \\nATOM    808  O   PRO B  44      65.670  60.696  14.211  1.00 52.63           O  \\nANISOU  808  O   PRO B  44     6335   7526   6134    124   -204    198       O  \\nATOM    809  CB  PRO B  44      63.662  58.387  13.318  1.00 37.49           C  \\nANISOU  809  CB  PRO B  44     4401   5584   4261    153   -110    307       C  \\nATOM    810  CG  PRO B  44      62.346  58.249  14.035  1.00 37.15           C  \\nANISOU  810  CG  PRO B  44     4356   5538   4221    200    -76    324       C  \\nATOM    811  CD  PRO B  44      62.484  59.080  15.276  1.00 30.25           C  \\nANISOU  811  CD  PRO B  44     3499   4699   3296    247    -91    290       C  \\nATOM    812  N   LYS B  45      66.913  58.939  13.554  1.00 37.61           N  \\nANISOU  812  N   LYS B  45     4391   5674   4226    110   -176    246       N  \\nATOM    813  CA  LYS B  45      68.052  59.736  13.143  1.00 44.38           C  \\nANISOU  813  CA  LYS B  45     5233   6535   5093     55   -211    210       C  \\nATOM    814  C   LYS B  45      67.792  60.449  11.828  1.00 35.76           C  \\nANISOU  814  C   LYS B  45     4158   5383   4044    -10   -213    222       C  \\nATOM    815  O   LYS B  45      67.149  59.906  10.919  1.00 29.01           O  \\nANISOU  815  O   LYS B  45     3311   4509   3203    -17   -189    258       O  \\nATOM    816  CB  LYS B  45      69.308  58.869  12.943  1.00 60.45           C  \\nANISOU  816  CB  LYS B  45     7227   8624   7119     52   -205    217       C  \\nATOM    817  CG  LYS B  45      69.351  57.475  13.552  1.00 78.92           C  \\nANISOU  817  CG  LYS B  45     9552  11003   9431    122   -175    253       C  \\nATOM    818  CD  LYS B  45      68.709  56.247  12.888  1.00 87.11           C  \\nANISOU  818  CD  LYS B  45    10596  12005  10497    135   -125    302       C  \\nATOM    819  CE  LYS B  45      67.187  56.091  12.888  1.00 50.55           C  \\nANISOU  819  CE  LYS B  45     5994   7324   5886    146    -97    327       C  \\nATOM    820  NZ  LYS B  45      66.833  54.899  12.064  1.00 42.78           N  \\nANISOU  820  NZ  LYS B  45     5003   6305   4945    139    -57    353       N  \\nATOM    821  N   SER B  46      68.328  61.653  11.703  1.00 31.26           N  \\nANISOU  821  N   SER B  46     3592   4786   3498    -59   -242    191       N  \\nATOM    822  CA  SER B  46      68.324  62.323  10.405  1.00 35.39           C  \\nANISOU  822  CA  SER B  46     4131   5260   4058   -121   -237    221       C  \\nATOM    823  C   SER B  46      69.269  61.650   9.408  1.00 35.34           C  \\nANISOU  823  C   SER B  46     4091   5292   4044   -160   -213    246       C  \\nATOM    824  O   SER B  46      70.139  60.867   9.786  1.00 50.43           O  \\nANISOU  824  O   SER B  46     5962   7263   5937   -146   -207    230       O  \\nATOM    825  CB  SER B  46      68.707  63.784  10.579  1.00 25.69           C  \\nANISOU  825  CB  SER B  46     2915   3975   2871   -167   -265    188       C  \\nATOM    826  OG  SER B  46      67.655  64.478  11.238  1.00 49.65           O  \\nANISOU  826  OG  SER B  46     5987   6959   5917   -126   -282    165       O  \\nATOM    827  N   SER B  47      69.082  61.947   8.129  1.00 27.37           N  \\nANISOU  827  N   SER B  47     3099   4259   3044   -199   -198    288       N  \\nATOM    828  CA  SER B  47      70.040  61.541   7.103  1.00 27.00           C  \\nANISOU  828  CA  SER B  47     3021   4254   2984   -240   -170    308       C  \\nATOM    829  C   SER B  47      70.473  62.775   6.309  1.00 34.37           C  \\nANISOU  829  C   SER B  47     3965   5149   3944   -310   -164    341       C  \\nATOM    830  O   SER B  47      70.051  63.899   6.611  1.00 36.96           O  \\nANISOU  830  O   SER B  47     4327   5407   4311   -324   -186    343       O  \\nATOM    831  CB  SER B  47      69.432  60.484   6.168  1.00 26.17           C  \\nANISOU  831  CB  SER B  47     2922   4174   2846   -216   -145    331       C  \\nATOM    832  OG  SER B  47      68.525  61.071   5.235  1.00 37.63           O  \\nANISOU  832  OG  SER B  47     4413   5595   4291   -226   -150    370       O  \\nATOM    833  N   LEU B  48      71.319  62.566   5.307  1.00 19.21           N  \\nANISOU  833  N   LEU B  48     2018   3272   2009   -351   -129    368       N  \\nATOM    834  CA  LEU B  48      71.726  63.643   4.411  1.00 38.49           C  \\nANISOU  834  CA  LEU B  48     4470   5681   4471   -418   -108    421       C  \\nATOM    835  C   LEU B  48      70.566  64.275   3.641  1.00 29.34           C  \\nANISOU  835  C   LEU B  48     3376   4470   3300   -406   -113    483       C  \\nATOM    836  O   LEU B  48      70.666  65.416   3.208  1.00 43.50           O  \\nANISOU  836  O   LEU B  48     5195   6204   5128   -450   -104    535       O  \\nATOM    837  CB  LEU B  48      72.750  63.135   3.394  1.00 39.57           C  \\nANISOU  837  CB  LEU B  48     4564   5896   4576   -452    -57    445       C  \\nATOM    838  CG  LEU B  48      74.216  63.024   3.808  1.00 56.16           C  \\nANISOU  838  CG  LEU B  48     6587   8044   6706   -493    -41    407       C  \\nATOM    839  CD1 LEU B  48      75.078  63.749   2.794  1.00 69.96           C  \\nANISOU  839  CD1 LEU B  48     8311   9802   8468   -573     12    464       C  \\nATOM    840  CD2 LEU B  48      74.443  63.587   5.203  1.00 73.90           C  \\nANISOU  840  CD2 LEU B  48     8817  10251   9012   -502    -89    348       C  \\nATOM    841  N   LEU B  49      69.480  63.526   3.459  1.00 26.85           N  \\nANISOU  841  N   LEU B  49     3083   4176   2943   -345   -127    480       N  \\nATOM    842  CA  LEU B  49      68.342  63.988   2.660  1.00 35.13           C  \\nANISOU  842  CA  LEU B  49     4180   5197   3969   -321   -140    535       C  \\nATOM    843  C   LEU B  49      67.092  64.267   3.478  1.00 33.49           C  \\nANISOU  843  C   LEU B  49     4000   4932   3792   -269   -181    514       C  \\nATOM    844  O   LEU B  49      66.201  64.990   3.030  1.00 35.20           O  \\nANISOU  844  O   LEU B  49     4255   5108   4012   -247   -199    560       O  \\nATOM    845  CB  LEU B  49      68.001  62.960   1.578  1.00 24.12           C  \\nANISOU  845  CB  LEU B  49     2780   3885   2500   -296   -128    542       C  \\nATOM    846  CG  LEU B  49      68.998  62.834   0.426  1.00 29.12           C  \\nANISOU  846  CG  LEU B  49     3397   4585   3082   -335    -83    577       C  \\nATOM    847  CD1 LEU B  49      68.595  61.712  -0.501  1.00 31.89           C  \\nANISOU  847  CD1 LEU B  49     3740   5020   3356   -300    -78    554       C  \\nATOM    848  CD2 LEU B  49      69.080  64.141  -0.339  1.00 23.18           C  \\nANISOU  848  CD2 LEU B  49     2682   3798   2328   -369    -68    672       C  \\nATOM    849  N   VAL B  50      67.023  63.684   4.670  1.00 37.11           N  \\nANISOU  849  N   VAL B  50     4437   5395   4268   -241   -192    450       N  \\nATOM    850  CA  VAL B  50      65.819  63.761   5.499  1.00 23.74           C  \\nANISOU  850  CA  VAL B  50     2759   3667   2593   -185   -218    426       C  \\nATOM    851  C   VAL B  50      66.091  64.361   6.880  1.00 33.57           C  \\nANISOU  851  C   VAL B  50     4006   4870   3879   -180   -233    377       C  \\nATOM    852  O   VAL B  50      67.027  63.968   7.590  1.00 45.68           O  \\nANISOU  852  O   VAL B  50     5509   6438   5410   -193   -228    335       O  \\nATOM    853  CB  VAL B  50      65.169  62.362   5.635  1.00 35.76           C  \\nANISOU  853  CB  VAL B  50     4256   5242   4088   -144   -212    401       C  \\nATOM    854  CG1 VAL B  50      64.070  62.355   6.682  1.00 37.18           C  \\nANISOU  854  CG1 VAL B  50     4439   5397   4291    -90   -225    376       C  \\nATOM    855  CG2 VAL B  50      64.634  61.908   4.273  1.00 28.95           C  \\nANISOU  855  CG2 VAL B  50     3395   4418   3188   -143   -212    430       C  \\nATOM    856  N   LYS B  51      65.273  65.339   7.244  1.00 28.20           N  \\nANISOU  856  N   LYS B  51     3359   4122   3234   -153   -254    376       N  \\nATOM    857  CA  LYS B  51      65.276  65.886   8.593  1.00 27.54           C  \\nANISOU  857  CA  LYS B  51     3280   4005   3180   -132   -271    312       C  \\nATOM    858  C   LYS B  51      64.160  65.233   9.415  1.00 27.97           C  \\nANISOU  858  C   LYS B  51     3327   4089   3210    -58   -271    287       C  \\nATOM    859  O   LYS B  51      63.055  65.007   8.899  1.00 31.28           O  \\nANISOU  859  O   LYS B  51     3751   4509   3626    -24   -269    320       O  \\nATOM    860  CB  LYS B  51      65.103  67.409   8.545  1.00 26.22           C  \\nANISOU  860  CB  LYS B  51     3153   3732   3075   -145   -288    316       C  \\nATOM    861  CG  LYS B  51      64.881  68.062   9.900  1.00 54.91           C  \\nANISOU  861  CG  LYS B  51     6798   7326   6739   -110   -309    234       C  \\nATOM    862  CD  LYS B  51      66.061  67.810  10.829  1.00 78.81           C  \\nANISOU  862  CD  LYS B  51     9792  10400   9754   -141   -318    161       C  \\nATOM    863  CE  LYS B  51      67.367  68.302  10.216  1.00 91.71           C  \\nANISOU  863  CE  LYS B  51    11409  12006  11429   -234   -315    172       C  \\nATOM    864  NZ  LYS B  51      68.533  67.955  11.068  1.00 91.52           N  \\nANISOU  864  NZ  LYS B  51    11335  12048  11390   -259   -330     98       N  \\nATOM    865  N   VAL B  52      64.453  64.914  10.682  1.00 41.42           N  \\nANISOU  865  N   VAL B  52     5015   5828   4895    -31   -271    230       N  \\nATOM    866  CA  VAL B  52      63.447  64.368  11.606  1.00 35.60           C  \\nANISOU  866  CA  VAL B  52     4271   5122   4133     40   -259    213       C  \\nATOM    867  C   VAL B  52      63.252  65.240  12.864  1.00 43.09           C  \\nANISOU  867  C   VAL B  52     5237   6051   5085     81   -275    145       C  \\nATOM    868  O   VAL B  52      64.171  65.355  13.684  1.00 48.02           O  \\nANISOU  868  O   VAL B  52     5854   6704   5689     74   -289     91       O  \\nATOM    869  CB  VAL B  52      63.804  62.937  12.060  1.00 28.23           C  \\nANISOU  869  CB  VAL B  52     3304   4266   3155     56   -232    219       C  \\nATOM    870  CG1 VAL B  52      62.609  62.288  12.748  1.00 28.03           C  \\nANISOU  870  CG1 VAL B  52     3269   4265   3115    120   -203    229       C  \\nATOM    871  CG2 VAL B  52      64.276  62.093  10.887  1.00 17.62           C  \\nANISOU  871  CG2 VAL B  52     1943   2942   1811     13   -218    261       C  \\nATOM    872  N   VAL B  53      62.070  65.857  13.001  1.00 47.96           N  \\nANISOU  872  N   VAL B  53     5872   6625   5725    129   -275    141       N  \\nATOM    873  CA  VAL B  53      61.658  66.538  14.245  1.00 32.61           C  \\nANISOU  873  CA  VAL B  53     3942   4675   3775    188   -280     69       C  \\nATOM    874  C   VAL B  53      61.021  65.531  15.198  1.00 34.00           C  \\nANISOU  874  C   VAL B  53     4091   4937   3889    253   -243     70       C  \\nATOM    875  O   VAL B  53      60.269  64.648  14.779  1.00 44.02           O  \\nANISOU  875  O   VAL B  53     5336   6232   5157    264   -212    129       O  \\nATOM    876  CB  VAL B  53      60.654  67.736  14.000  1.00 85.12           C  \\nANISOU  876  CB  VAL B  53    10622  11235  10484    222   -292     61       C  \\nATOM    877  CG1 VAL B  53      59.205  67.484  14.602  1.00 25.10           C  \\nANISOU  877  CG1 VAL B  53     3003   3669   2866    310   -263     58       C  \\nATOM    878  CG2 VAL B  53      61.233  69.020  14.551  1.00 85.78           C  \\nANISOU  878  CG2 VAL B  53    10739  11245  10607    212   -323    -21       C  \\nATOM    879  N   CYS B  54      61.329  65.656  16.479  1.00 36.68           N  \\nANISOU  879  N   CYS B  54     4434   5325   4178    294   -245      5       N  \\nATOM    880  CA  CYS B  54      60.600  64.908  17.493  1.00 32.77           C  \\nANISOU  880  CA  CYS B  54     3921   4911   3620    368   -200     13       C  \\nATOM    881  C   CYS B  54      60.146  65.854  18.591  1.00 32.61           C  \\nANISOU  881  C   CYS B  54     3920   4897   3574    436   -205    -74       C  \\nATOM    882  O   CYS B  54      60.869  66.782  18.966  1.00 41.41           O  \\nANISOU  882  O   CYS B  54     5058   5986   4692    424   -251   -160       O  \\nATOM    883  CB  CYS B  54      61.449  63.765  18.061  1.00 34.88           C  \\nANISOU  883  CB  CYS B  54     4168   5267   3817    371   -186     37       C  \\nATOM    884  SG  CYS B  54      61.630  62.348  16.926  1.00 35.72           S  \\nANISOU  884  SG  CYS B  54     4248   5372   3953    319   -157    138       S  \\nATOM    885  N   CYS B  55      58.941  65.623  19.099  1.00 31.10           N  \\nANISOU  885  N   CYS B  55     3714   4739   3362    505   -157    -58       N  \\nATOM    886  CA  CYS B  55      58.366  66.475  20.130  1.00 29.03           C  \\nANISOU  886  CA  CYS B  55     3467   4493   3070    583   -151   -142       C  \\nATOM    887  C   CYS B  55      57.407  65.619  20.964  1.00 36.84           C  \\nANISOU  887  C   CYS B  55     4425   5580   3994    658    -75    -99       C  \\nATOM    888  O   CYS B  55      57.002  64.531  20.529  1.00 27.52           O  \\nANISOU  888  O   CYS B  55     3211   4420   2827    638    -31     -3       O  \\nATOM    889  CB  CYS B  55      57.639  67.645  19.481  1.00 22.49           C  \\nANISOU  889  CB  CYS B  55     2655   3555   2334    589   -172   -170       C  \\nATOM    890  SG  CYS B  55      56.421  67.108  18.255  1.00 32.55           S  \\nANISOU  890  SG  CYS B  55     3892   4798   3679    578   -141    -60       S  \\nATOM    891  N   ASN B  56      57.052  66.086  22.160  1.00 42.59           N  \\nANISOU  891  N   ASN B  56     5162   6369   4653    741    -55   -172       N  \\nATOM    892  CA  ASN B  56      56.300  65.236  23.084  1.00 41.38           C  \\nANISOU  892  CA  ASN B  56     4979   6325   4419    813     27   -123       C  \\nATOM    893  C   ASN B  56      55.027  65.824  23.687  1.00 42.90           C  \\nANISOU  893  C   ASN B  56     5156   6540   4604    900     77   -165       C  \\nATOM    894  O   ASN B  56      54.570  65.367  24.735  1.00 45.08           O  \\nANISOU  894  O   ASN B  56     5415   6925   4787    974    145   -151       O  \\nATOM    895  CB  ASN B  56      57.210  64.693  24.196  1.00 48.83           C  \\nANISOU  895  CB  ASN B  56     5936   7385   5233    848     30   -135       C  \\nATOM    896  CG  ASN B  56      57.917  65.794  24.966  1.00 69.44           C  \\nANISOU  896  CG  ASN B  56     8582  10016   7784    881    -35   -279       C  \\nATOM    897  OD1 ASN B  56      57.709  66.983  24.707  1.00 84.25           O  \\nANISOU  897  OD1 ASN B  56    10479  11806   9728    877    -74   -372       O  \\nATOM    898  ND2 ASN B  56      58.758  65.403  25.923  1.00 54.30           N  \\nANISOU  898  ND2 ASN B  56     6673   8214   5745    917    -48   -302       N  \\nATOM    899  N   LYS B  57      54.456  66.831  23.036  1.00 40.72           N  \\nANISOU  899  N   LYS B  57     4884   6165   4422    900     47   -210       N  \\nATOM    900  CA  LYS B  57      53.116  67.281  23.405  1.00 51.14           C  \\nANISOU  900  CA  LYS B  57     6174   7501   5757    984    100   -234       C  \\nATOM    901  C   LYS B  57      52.111  66.851  22.336  1.00 46.04           C  \\nANISOU  901  C   LYS B  57     5472   6810   5211    953    124   -140       C  \\nATOM    902  O   LYS B  57      52.494  66.504  21.218  1.00 36.44           O  \\nANISOU  902  O   LYS B  57     4255   5531   4059    870     84    -81       O  \\nATOM    903  CB  LYS B  57      53.055  68.798  23.675  1.00 46.19           C  \\nANISOU  903  CB  LYS B  57     5588   6805   5157   1037     55   -368       C  \\nATOM    904  CG  LYS B  57      53.683  69.675  22.612  1.00 64.53           C  \\nANISOU  904  CG  LYS B  57     7952   8980   7588    966    -31   -394       C  \\nATOM    905  CD  LYS B  57      55.096  70.080  23.014  1.00 73.37           C  \\nANISOU  905  CD  LYS B  57     9123  10087   8669    924    -93   -481       C  \\nATOM    906  CE  LYS B  57      56.024  70.225  21.814  1.00 62.62           C  \\nANISOU  906  CE  LYS B  57     7783   8618   7393    813   -156   -439       C  \\nATOM    907  NZ  LYS B  57      57.424  69.809  22.168  1.00 63.61           N  \\nANISOU  907  NZ  LYS B  57     7921   8795   7454    755   -192   -464       N  \\nATOM    908  N   ASP B  58      50.831  66.845  22.693  1.00 32.23           N  \\nANISOU  908  N   ASP B  58     3668   5106   3472   1023    191   -131       N  \\nATOM    909  CA  ASP B  58      49.782  66.390  21.774  1.00 43.23           C  \\nANISOU  909  CA  ASP B  58     4990   6478   4958    999    214    -51       C  \\nATOM    910  C   ASP B  58      49.795  67.089  20.414  1.00 39.99           C  \\nANISOU  910  C   ASP B  58     4593   5949   4652    957    130    -51       C  \\nATOM    911  O   ASP B  58      49.765  68.322  20.331  1.00 25.31           O  \\nANISOU  911  O   ASP B  58     2772   4018   2827   1001     85   -122       O  \\nATOM    912  CB  ASP B  58      48.400  66.541  22.421  1.00 47.82           C  \\nANISOU  912  CB  ASP B  58     5503   7126   5541   1092    293    -63       C  \\nATOM    913  CG  ASP B  58      47.916  65.263  23.083  1.00 51.38           C  \\nANISOU  913  CG  ASP B  58     5891   7686   5944   1092    399     19       C  \\nATOM    914  OD1 ASP B  58      48.742  64.352  23.327  1.00 47.31           O  \\nANISOU  914  OD1 ASP B  58     5402   7201   5371   1042    413     73       O  \\nATOM    915  OD2 ASP B  58      46.704  65.174  23.364  1.00 67.10           O  \\nANISOU  915  OD2 ASP B  58     7803   9730   7961   1143    472     35       O  \\nATOM    916  N   LYS B  59      49.842  66.285  19.356  1.00 33.36           N  \\nANISOU  916  N   LYS B  59     3725   5091   3861    876    112     29       N  \\nATOM    917  CA  LYS B  59      49.729  66.784  17.986  1.00 40.93           C  \\nANISOU  917  CA  LYS B  59     4686   5962   4903    841     41     50       C  \\nATOM    918  C   LYS B  59      50.759  67.864  17.662  1.00 47.45           C  \\nANISOU  918  C   LYS B  59     5599   6691   5738    823    -32      3       C  \\nATOM    919  O   LYS B  59      50.489  68.782  16.871  1.00 39.44           O  \\nANISOU  919  O   LYS B  59     4602   5595   4790    839    -82      2       O  \\nATOM    920  CB  LYS B  59      48.322  67.334  17.719  1.00 47.02           C  \\nANISOU  920  CB  LYS B  59     5393   6731   5740    913     48     45       C  \\nATOM    921  CG  LYS B  59      47.198  66.301  17.738  1.00 54.33           C  \\nANISOU  921  CG  LYS B  59     6212   7741   6690    913    112     96       C  \\nATOM    922  CD  LYS B  59      45.920  66.910  17.170  1.00 55.75           C  \\nANISOU  922  CD  LYS B  59     6322   7914   6948    975     93     92       C  \\nATOM    923  CE  LYS B  59      44.718  66.014  17.370  1.00 60.43           C  \\nANISOU  923  CE  LYS B  59     6790   8597   7573    981    164    125       C  \\nATOM    924  NZ  LYS B  59      43.500  66.671  16.824  1.00 68.69           N  \\nANISOU  924  NZ  LYS B  59     7758   9646   8695   1051    137    115       N  \\nATOM    925  N   CYS B  60      51.934  67.741  18.272  1.00 32.59           N  \\nANISOU  925  N   CYS B  60     3770   4821   3794    790    -38    -29       N  \\nATOM    926  CA  CYS B  60      52.964  68.758  18.173  1.00 37.12           C  \\nANISOU  926  CA  CYS B  60     4416   5308   4380    767    -98    -88       C  \\nATOM    927  C   CYS B  60      53.772  68.630  16.898  1.00 28.86           C  \\nANISOU  927  C   CYS B  60     3393   4200   3374    672   -149    -29       C  \\nATOM    928  O   CYS B  60      54.590  69.492  16.590  1.00 36.38           O  \\nANISOU  928  O   CYS B  60     4399   5067   4357    639   -196    -59       O  \\nATOM    929  CB  CYS B  60      53.909  68.639  19.357  1.00 26.48           C  \\nANISOU  929  CB  CYS B  60     3101   4016   2946    770    -89   -155       C  \\nATOM    930  SG  CYS B  60      54.767  67.078  19.417  1.00 34.40           S  \\nANISOU  930  SG  CYS B  60     4085   5108   3877    702    -66    -82       S  \\nATOM    931  N   ASN B  61      53.570  67.532  16.181  1.00 34.85           N  \\nANISOU  931  N   ASN B  61     4109   5002   4131    627   -135     51       N  \\nATOM    932  CA  ASN B  61      54.320  67.277  14.952  1.00 40.98           C  \\nANISOU  932  CA  ASN B  61     4902   5742   4929    543   -176    106       C  \\nATOM    933  C   ASN B  61      53.527  67.681  13.714  1.00 38.08           C  \\nANISOU  933  C   ASN B  61     4519   5329   4621    550   -208    156       C  \\nATOM    934  O   ASN B  61      52.620  68.505  13.824  1.00 38.33           O  \\nANISOU  934  O   ASN B  61     4543   5329   4692    622   -213    138       O  \\nATOM    935  CB  ASN B  61      54.758  65.809  14.868  1.00 36.22           C  \\nANISOU  935  CB  ASN B  61     4268   5210   4284    487   -147    151       C  \\nATOM    936  CG  ASN B  61      53.595  64.859  14.660  1.00 35.41           C  \\nANISOU  936  CG  ASN B  61     4095   5160   4200    501   -108    194       C  \\nATOM    937  OD1 ASN B  61      52.454  65.157  15.013  1.00 39.72           O  \\nANISOU  937  OD1 ASN B  61     4604   5721   4768    564    -85    183       O  \\nATOM    938  ND2 ASN B  61      53.885  63.704  14.085  1.00 22.34           N  \\nANISOU  938  ND2 ASN B  61     2415   3530   2541    441    -99    238       N  \\nATOM    939  OXT ASN B  61      53.771  67.207  12.599  1.00 27.54           O  \\nANISOU  939  OXT ASN B  61     3177   3996   3292    493   -232    212       O  \\nTER     940      ASN B  61                                                      \\nHETATM  941  O   HOH A 101      74.826  53.239   3.395  1.00 22.77           O  \\nHETATM  942  O   HOH A 102      63.231  58.783  -3.483  1.00 25.28           O  \\nHETATM  943  O   HOH A 103      73.299  55.368  -3.080  1.00 26.84           O  \\nHETATM  944  O   HOH A 104      61.514  52.082  -0.408  1.00 31.79           O  \\nHETATM  945  O   HOH A 105      59.257  54.188  -4.092  1.00 26.51           O  \\nHETATM  946  O   HOH A 106      73.623  43.081  26.104  1.00 35.69           O  \\nHETATM  947  O   HOH A 107      78.304  54.113   8.025  1.00 38.66           O  \\nHETATM  948  O   HOH A 108      58.727  45.532   3.585  1.00 41.75           O  \\nHETATM  949  O   HOH A 109      70.446  56.833   6.300  1.00 35.79           O  \\nHETATM  950  O   HOH A 110      64.991  36.479   3.699  1.00 41.95           O  \\nHETATM  951  O   HOH A 111      70.670  42.742  15.677  1.00 35.42           O  \\nHETATM  952  O   HOH A 112      81.363  50.971   6.892  1.00 34.84           O  \\nHETATM  953  O   HOH A 113      82.811  49.323   5.484  1.00 38.20           O  \\nHETATM  954  O   HOH A 114      69.052  40.833  18.157  1.00 37.88           O  \\nHETATM  955  O   HOH A 115      63.711  50.599  15.551  1.00 35.91           O  \\nHETATM  956  O   HOH A 116      65.484  52.258  13.751  1.00 32.16           O  \\nHETATM  957  O   HOH A 117      63.491  42.646  14.117  1.00 35.54           O  \\nHETATM  958  O   HOH A 118      85.178  48.471   5.216  1.00 35.21           O  \\nHETATM  959  O   HOH A 119      80.115  48.497   4.430  1.00 34.44           O  \\nHETATM  960  O   HOH A 120      71.140  45.925  -1.602  1.00 42.34           O  \\nHETATM  961  O   HOH B 101      52.598  53.756  15.975  1.00 18.32           O  \\nHETATM  962  O   HOH B 102      49.302  50.174  22.944  1.00 29.63           O  \\nHETATM  963  O   HOH B 103      54.960  62.281  25.517  1.00 23.82           O  \\nHETATM  964  O   HOH B 104      61.168  67.348   9.729  1.00 26.40           O  \\nHETATM  965  O   HOH B 105      49.709  57.223  23.826  1.00 32.14           O  \\nHETATM  966  O   HOH B 106      52.767  59.258   7.687  1.00 25.09           O  \\nHETATM  967  O   HOH B 107      63.285  70.140   6.424  1.00 47.22           O  \\nHETATM  968  O   HOH B 108      59.616  71.152   8.662  1.00 56.53           O  \\nHETATM  969  O   HOH B 109      66.877  56.706  18.054  1.00 36.51           O  \\nHETATM  970  O   HOH B 110      50.733  60.161  26.570  1.00 42.81           O  \\nHETATM  971  O   HOH B 111      59.697  67.987   2.378  1.00 30.71           O  \\nHETATM  972  O   HOH B 112      44.843  59.342  10.776  1.00 35.60           O  \\nHETATM  973  O   HOH B 113      53.213  60.672  26.684  1.00 42.95           O  \\nHETATM  974  O   HOH B 114      56.156  70.611   7.874  1.00 34.65           O  \\nHETATM  975  O   HOH B 115      51.766  55.791  24.122  1.00 35.19           O  \\nHETATM  976  O   HOH B 116      53.194  56.580  10.270  1.00 43.06           O  \\nHETATM  977  O   HOH B 117      57.713  54.137  15.381  1.00 48.65           O  \\nHETATM  978  O   HOH B 118      57.898  74.940   7.339  1.00 28.14           O  \\nHETATM  979  O   HOH B 119      59.142  57.634  24.089  1.00 52.38           O  \\nHETATM  980  O   HOH B 120      61.481  69.904  10.940  1.00 33.94           O  \\nHETATM  981  O   HOH B 121      59.265  55.850  25.363  1.00 46.67           O  \\nHETATM  982  O   HOH B 122      52.070  51.440  14.411  1.00 51.67           O  \\nHETATM  983  O   HOH B 123      42.965  59.027  18.585  1.00 41.48           O  \\nHETATM  984  O   HOH B 124      63.400  71.147  10.372  1.00 46.17           O  \\nHETATM  985  O   HOH B 125      50.060  57.816  28.365  1.00 43.81           O  \\nHETATM  986  O   HOH B 126      46.529  60.864  24.401  1.00 36.51           O  \\nHETATM  987  O   HOH B 127      63.974  66.922  17.310  1.00 25.94           O  \\nHETATM  988  O   HOH B 128      57.982  71.615  12.191  1.00 52.48           O  \\nHETATM  989  O   HOH B 129      48.760  51.806  17.377  1.00 49.01           O  \\nCONECT   23  170                                                                \\nCONECT  119  308                                                                \\nCONECT  170   23                                                                \\nCONECT  308  119                                                                \\nCONECT  334  414                                                                \\nCONECT  414  334                                                                \\nCONECT  420  460                                                                \\nCONECT  460  420                                                                \\nCONECT  493  640                                                                \\nCONECT  589  778                                                                \\nCONECT  640  493                                                                \\nCONECT  778  589                                                                \\nCONECT  804  884                                                                \\nCONECT  884  804                                                                \\nCONECT  890  930                                                                \\nCONECT  930  890                                                                \\nMASTER      240    0    0    0   10    0    0    6  987    2   16   10          \\nEND                                                                             \\n\",\"pdb\");\n\tviewer_1725285451326232.setStyle({\"cartoon\": {\"color\": \"spectrum\"}});\n\tviewer_1725285451326232.setBackgroundColor(\"white\");\n\tviewer_1725285451326232.zoomTo();\n\tviewer_1725285451326232.zoom(2,800);\nviewer_1725285451326232.render();\n});\n</script>",
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              "\tviewer_1725285451326232.addModel(\"HEADER    TOXIN                                   06-JUN-12   3VTS              \\nTITLE     CRYSTAL STRUCTURE OF A THREE FINGER TOXIN FROM SNAKE VENOM            \\nCOMPND    MOL_ID: 1;                                                            \\nCOMPND   2 MOLECULE: CYTOTOXIN 1;                                               \\nCOMPND   3 CHAIN: A, B;                                                         \\nCOMPND   4 SYNONYM: HEMOLYTIC PROTEIN 12B, THREE FINGER TOXIN                   \\nSOURCE    MOL_ID: 1;                                                            \\nSOURCE   2 ORGANISM_SCIENTIFIC: HEMACHATUS HAEMACHATUS;                         \\nSOURCE   3 ORGANISM_COMMON: RINGHALS;                                           \\nSOURCE   4 ORGANISM_TAXID: 8626                                                 \\nKEYWDS    THREE FINGER TOXIN, VENOM TOXIN, TOXIN                                \\nEXPDTA    X-RAY DIFFRACTION                                                     \\nAUTHOR    C.JOBICHEN,J.SIVARAMAN                                                \\nREVDAT   3   08-NOV-23 3VTS    1       REMARK                                   \\nREVDAT   2   27-NOV-13 3VTS    1       JRNL                                     \\nREVDAT   1   07-NOV-12 3VTS    0                                                \\nJRNL        AUTH   V.M.GIRISH,S.KUMAR,L.JOSEPH,C.JOBICHEN,R.M.KINI,J.SIVARAMAN  \\nJRNL        TITL   IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF A NEW      \\nJRNL        TITL 2 THREE-FINGER TOXIN HEMACHATOXIN FROM HEMACHATUS HAEMACHATUS  \\nJRNL        TITL 3 VENOM.                                                       \\nJRNL        REF    PLOS ONE                      V.   7 48112 2012              \\nJRNL        REFN                   ESSN 1932-6203                               \\nJRNL        PMID   23144733                                                     \\nJRNL        DOI    10.1371/JOURNAL.PONE.0048112                                 \\nREMARK   2                                                                      \\nREMARK   2 RESOLUTION.    2.43 ANGSTROMS.                                       \\nREMARK   3                                                                      \\nREMARK   3 REFINEMENT.                                                          \\nREMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.7.3_928)                    \\nREMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            \\nREMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           \\nREMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            \\nREMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              \\nREMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               \\nREMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           \\nREMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  \\nREMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  \\nREMARK   3                                                                      \\nREMARK   3    REFINEMENT TARGET : ML                                            \\nREMARK   3                                                                      \\nREMARK   3  DATA USED IN REFINEMENT.                                            \\nREMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.43                           \\nREMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 30.11                          \\nREMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.350                          \\nREMARK   3   COMPLETENESS FOR RANGE        (%) : 96.6                           \\nREMARK   3   NUMBER OF REFLECTIONS             : 5614                           \\nREMARK   3                                                                      \\nREMARK   3  FIT TO DATA USED IN REFINEMENT.                                     \\nREMARK   3   R VALUE     (WORKING + TEST SET) : 0.237                           \\nREMARK   3   R VALUE            (WORKING SET) : 0.232                           \\nREMARK   3   FREE R VALUE                     : 0.281                           \\nREMARK   3   FREE R VALUE TEST SET SIZE   (%) : 10.210                          \\nREMARK   3   FREE R VALUE TEST SET COUNT      : 573                             \\nREMARK   3                                                                      \\nREMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           \\nREMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        \\nREMARK   3     1 30.1147 -  3.8493    0.93     1265   148  0.1914 0.2082        \\nREMARK   3     2  3.8493 -  3.0562    0.97     1263   138  0.2437 0.3212        \\nREMARK   3     3  3.0562 -  2.6702    0.99     1271   148  0.2594 0.3343        \\nREMARK   3     4  2.6702 -  2.4261    0.97     1242   139  0.3162 0.3916        \\nREMARK   3                                                                      \\nREMARK   3  BULK SOLVENT MODELLING.                                             \\nREMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       \\nREMARK   3   SOLVENT RADIUS     : 1.20                                          \\nREMARK   3   SHRINKAGE RADIUS   : 0.98                                          \\nREMARK   3   K_SOL              : 0.29                                          \\nREMARK   3   B_SOL              : 19.33                                         \\nREMARK   3                                                                      \\nREMARK   3  ERROR ESTIMATES.                                                    \\nREMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.410            \\nREMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 29.360           \\nREMARK   3                                                                      \\nREMARK   3  B VALUES.                                                           \\nREMARK   3   FROM WILSON PLOT           (A**2) : NULL                           \\nREMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           \\nREMARK   3   OVERALL ANISOTROPIC B VALUE.                                       \\nREMARK   3    B11 (A**2) : 1.94010                                              \\nREMARK   3    B22 (A**2) : 4.56620                                              \\nREMARK   3    B33 (A**2) : -5.46690                                             \\nREMARK   3    B12 (A**2) : 0.00000                                              \\nREMARK   3    B13 (A**2) : 0.00000                                              \\nREMARK   3    B23 (A**2) : 0.00000                                              \\nREMARK   3                                                                      \\nREMARK   3  TWINNING INFORMATION.                                               \\nREMARK   3   FRACTION: NULL                                                     \\nREMARK   3   OPERATOR: NULL                                                     \\nREMARK   3                                                                      \\nREMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       \\nREMARK   3                 RMSD          COUNT                                  \\nREMARK   3   BOND      :  0.008            960                                  \\nREMARK   3   ANGLE     :  1.377           1272                                  \\nREMARK   3   CHIRALITY :  0.088            150                                  \\nREMARK   3   PLANARITY :  0.006            154                                  \\nREMARK   3   DIHEDRAL  : 13.951            392                                  \\nREMARK   3                                                                      \\nREMARK   3  TLS DETAILS                                                         \\nREMARK   3   NUMBER OF TLS GROUPS  : 1                                          \\nREMARK   3   TLS GROUP : 1                                                      \\nREMARK   3    SELECTION: ALL                                                    \\nREMARK   3    ORIGIN FOR THE GROUP (A):  61.4575  56.8640   9.0170              \\nREMARK   3    T TENSOR                                                          \\nREMARK   3      T11:   0.1738 T22:   0.2887                                     \\nREMARK   3      T33:   0.1768 T12:   0.0037                                     \\nREMARK   3      T13:  -0.0101 T23:   0.0331                                     \\nREMARK   3    L TENSOR                                                          \\nREMARK   3      L11:   1.9536 L22:   1.1002                                     \\nREMARK   3      L33:   1.2418 L12:  -0.4658                                     \\nREMARK   3      L13:  -0.2144 L23:   0.1753                                     \\nREMARK   3    S TENSOR                                                          \\nREMARK   3      S11:  -0.1041 S12:  -0.0023 S13:  -0.0502                       \\nREMARK   3      S21:   0.0104 S22:   0.0572 S23:   0.0982                       \\nREMARK   3      S31:  -0.0512 S32:  -0.0039 S33:   0.0483                       \\nREMARK   3                                                                      \\nREMARK   3  NCS DETAILS                                                         \\nREMARK   3   NUMBER OF NCS GROUPS : 1                                           \\nREMARK   3   NCS GROUP : 1                                                      \\nREMARK   3    NCS OPERATOR : 1                                                  \\nREMARK   3     REFERENCE SELECTION: CHAIN A AND (RESSEQ 1:61 )                  \\nREMARK   3     SELECTION          : CHAIN B AND (RESSEQ 1:61 )                  \\nREMARK   3     ATOM PAIRS NUMBER  : 469                                         \\nREMARK   3     RMSD               : 0.063                                       \\nREMARK   3                                                                      \\nREMARK   3  OTHER REFINEMENT REMARKS: NULL                                      \\nREMARK   4                                                                      \\nREMARK   4 3VTS COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         \\nREMARK 100                                                                      \\nREMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 14-JUN-12.                  \\nREMARK 100 THE DEPOSITION ID IS D_1000095490.                                   \\nREMARK 200                                                                      \\nREMARK 200 EXPERIMENTAL DETAILS                                                 \\nREMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  \\nREMARK 200  DATE OF DATA COLLECTION        : 31-OCT-08                          \\nREMARK 200  TEMPERATURE           (KELVIN) : 100                                \\nREMARK 200  PH                             : 4.5                                \\nREMARK 200  NUMBER OF CRYSTALS USED        : 1                                  \\nREMARK 200                                                                      \\nREMARK 200  SYNCHROTRON              (Y/N) : N                                  \\nREMARK 200  RADIATION SOURCE               : ROTATING ANODE                     \\nREMARK 200  BEAMLINE                       : NULL                               \\nREMARK 200  X-RAY GENERATOR MODEL          : RIGAKU                             \\nREMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  \\nREMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418                             \\nREMARK 200  MONOCHROMATOR                  : GRAPHITE                           \\nREMARK 200  OPTICS                         : MIRRORS                            \\nREMARK 200                                                                      \\nREMARK 200  DETECTOR TYPE                  : IMAGE PLATE                        \\nREMARK 200  DETECTOR MANUFACTURER          : RIGAKU RAXIS IV++                  \\nREMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           \\nREMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           \\nREMARK 200                                                                      \\nREMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 5614                               \\nREMARK 200  RESOLUTION RANGE HIGH      (A) : 2.426                              \\nREMARK 200  RESOLUTION RANGE LOW       (A) : 30.112                             \\nREMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.000                              \\nREMARK 200                                                                      \\nREMARK 200 OVERALL.                                                             \\nREMARK 200  COMPLETENESS FOR RANGE     (%) : 96.2                               \\nREMARK 200  DATA REDUNDANCY                : 3.900                              \\nREMARK 200  R MERGE                    (I) : 0.06400                            \\nREMARK 200  R SYM                      (I) : NULL                               \\nREMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 20.6000                            \\nREMARK 200                                                                      \\nREMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     \\nREMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL                     \\nREMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL                     \\nREMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               \\nREMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               \\nREMARK 200  R MERGE FOR SHELL          (I) : NULL                               \\nREMARK 200  R SYM FOR SHELL            (I) : NULL                               \\nREMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               \\nREMARK 200                                                                      \\nREMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              \\nREMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        \\nREMARK 200 SOFTWARE USED: PHASER                                                \\nREMARK 200 STARTING MODEL: 1TGX                                                 \\nREMARK 200                                                                      \\nREMARK 200 REMARK: NULL                                                         \\nREMARK 280                                                                      \\nREMARK 280 CRYSTAL                                                              \\nREMARK 280 SOLVENT CONTENT, VS   (%): 53.09                                     \\nREMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.62                     \\nREMARK 280                                                                      \\nREMARK 280 CRYSTALLIZATION CONDITIONS: 150MM AMMONIUM ACETATE, 100MM SODIUM     \\nREMARK 280  ACETATE, 25% POLYETHYLENE GLYCOL 4000 , PH 4.5, VAPOR DIFFUSION,    \\nREMARK 280  HANGING DROP, TEMPERATURE 298K                                      \\nREMARK 290                                                                      \\nREMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            \\nREMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       \\nREMARK 290                                                                      \\nREMARK 290      SYMOP   SYMMETRY                                                \\nREMARK 290     NNNMMM   OPERATOR                                                \\nREMARK 290       1555   X,Y,Z                                                   \\nREMARK 290       2555   -X+1/2,-Y,Z+1/2                                         \\nREMARK 290       3555   -X,Y+1/2,-Z+1/2                                         \\nREMARK 290       4555   X+1/2,-Y+1/2,-Z                                         \\nREMARK 290                                                                      \\nREMARK 290     WHERE NNN -> OPERATOR NUMBER                                     \\nREMARK 290           MMM -> TRANSLATION VECTOR                                  \\nREMARK 290                                                                      \\nREMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            \\nREMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             \\nREMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                \\nREMARK 290 RELATED MOLECULES.                                                   \\nREMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            \\nREMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            \\nREMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            \\nREMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       24.85900            \\nREMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            \\nREMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       28.90650            \\nREMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            \\nREMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       25.02850            \\nREMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       28.90650            \\nREMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       24.85900            \\nREMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       25.02850            \\nREMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            \\nREMARK 290                                                                      \\nREMARK 290 REMARK: NULL                                                         \\nREMARK 300                                                                      \\nREMARK 300 BIOMOLECULE: 1                                                       \\nREMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                \\nREMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  \\nREMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               \\nREMARK 300 BURIED SURFACE AREA.                                                 \\nREMARK 350                                                                      \\nREMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           \\nREMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                \\nREMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          \\nREMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          \\nREMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               \\nREMARK 350                                                                      \\nREMARK 350 BIOMOLECULE: 1                                                       \\nREMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           \\nREMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    \\nREMARK 350 SOFTWARE USED: PISA                                                  \\nREMARK 350 TOTAL BURIED SURFACE AREA: 1160 ANGSTROM**2                          \\nREMARK 350 SURFACE AREA OF THE COMPLEX: 7460 ANGSTROM**2                        \\nREMARK 350 CHANGE IN SOLVENT FREE ENERGY: -8.0 KCAL/MOL                         \\nREMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  \\nREMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            \\nREMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            \\nREMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            \\nREMARK 500                                                                      \\nREMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         \\nREMARK 500 SUBTOPIC: TORSION ANGLES                                             \\nREMARK 500                                                                      \\nREMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            \\nREMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               \\nREMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             \\nREMARK 500                                                                      \\nREMARK 500 STANDARD TABLE:                                                      \\nREMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    \\nREMARK 500                                                                      \\nREMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           \\nREMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            \\nREMARK 500                                                                      \\nREMARK 500  M RES CSSEQI        PSI       PHI                                   \\nREMARK 500    PHE A  10      -54.71     71.86                                   \\nREMARK 500    PHE B  10      -53.63     71.59                                   \\nREMARK 500                                                                      \\nREMARK 500 REMARK: NULL                                                         \\nREMARK 999                                                                      \\nREMARK 999 SEQUENCE                                                             \\nREMARK 999 THE AUTHOR DEPOSITED SEQUENCE OF THIS PROTEIN AS THE CODE B3EWH9     \\nREMARK 999 BUT IT DOES NOT APPEAR IN TE SEQUENCE DATABASE YET.                  \\nDBREF  3VTS A    1    61  PDB    3VTS     3VTS             1     61             \\nDBREF  3VTS B    1    61  PDB    3VTS     3VTS             1     61             \\nSEQRES   1 A   61  LEU LYS CYS HIS ASN LYS LEU VAL PRO PHE LEU SER LYS          \\nSEQRES   2 A   61  THR CYS PRO GLU GLY LYS ASN LEU CYS TYR LYS MET THR          \\nSEQRES   3 A   61  LEU MET LYS MET PRO LYS ILE PRO ILE LYS ARG GLY CYS          \\nSEQRES   4 A   61  THR ASP ALA CYS PRO LYS SER SER LEU LEU VAL LYS VAL          \\nSEQRES   5 A   61  VAL CYS CYS ASN LYS ASP LYS CYS ASN                          \\nSEQRES   1 B   61  LEU LYS CYS HIS ASN LYS LEU VAL PRO PHE LEU SER LYS          \\nSEQRES   2 B   61  THR CYS PRO GLU GLY LYS ASN LEU CYS TYR LYS MET THR          \\nSEQRES   3 B   61  LEU MET LYS MET PRO LYS ILE PRO ILE LYS ARG GLY CYS          \\nSEQRES   4 B   61  THR ASP ALA CYS PRO LYS SER SER LEU LEU VAL LYS VAL          \\nSEQRES   5 B   61  VAL CYS CYS ASN LYS ASP LYS CYS ASN                          \\nFORMUL   3  HOH   *49(H2 O)                                                     \\nSHEET    1   A 2 LYS A   2  HIS A   4  0                                        \\nSHEET    2   A 2 SER A  12  THR A  14 -1  O  LYS A  13   N  CYS A   3           \\nSHEET    1   B 3 MET A  30  THR A  40  0                                        \\nSHEET    2   B 3 LEU A  21  LEU A  27 -1  N  MET A  25   O  ILE A  35           \\nSHEET    3   B 3 VAL A  50  CYS A  55 -1  O  CYS A  55   N  CYS A  22           \\nSHEET    1   C 2 LYS B   2  HIS B   4  0                                        \\nSHEET    2   C 2 SER B  12  THR B  14 -1  O  LYS B  13   N  CYS B   3           \\nSHEET    1   D 3 MET B  30  THR B  40  0                                        \\nSHEET    2   D 3 LEU B  21  LEU B  27 -1  N  MET B  25   O  ILE B  35           \\nSHEET    3   D 3 VAL B  50  CYS B  55 -1  O  CYS B  55   N  CYS B  22           \\nSSBOND   1 CYS A    3    CYS A   22                          1555   1555  2.04  \\nSSBOND   2 CYS A   15    CYS A   39                          1555   1555  2.04  \\nSSBOND   3 CYS A   43    CYS A   54                          1555   1555  2.03  \\nSSBOND   4 CYS A   55    CYS A   60                          1555   1555  2.05  \\nSSBOND   5 CYS B    3    CYS B   22                          1555   1555  2.02  \\nSSBOND   6 CYS B   15    CYS B   39                          1555   1555  2.04  \\nSSBOND   7 CYS B   43    CYS B   54                          1555   1555  2.04  \\nSSBOND   8 CYS B   55    CYS B   60                          1555   1555  2.02  \\nCRYST1   49.718   50.057   57.813  90.00  90.00  90.00 P 21 21 21    8          \\nORIGX1      1.000000  0.000000  0.000000        0.00000                         \\nORIGX2      0.000000  1.000000  0.000000        0.00000                         \\nORIGX3      0.000000  0.000000  1.000000        0.00000                         \\nSCALE1      0.020113  0.000000  0.000000        0.00000                         \\nSCALE2      0.000000  0.019977  0.000000        0.00000                         \\nSCALE3      0.000000  0.000000  0.017297        0.00000                         \\nATOM      1  N   LEU A   1      73.350  41.259  12.373  1.00 31.31           N  \\nANISOU    1  N   LEU A   1     3437   4478   3981    788    346    646       N  \\nATOM      2  CA  LEU A   1      72.878  41.778  11.093  1.00 45.01           C  \\nANISOU    2  CA  LEU A   1     5169   6206   5728    674    333    531       C  \\nATOM      3  C   LEU A   1      73.619  43.058  10.733  1.00 42.35           C  \\nANISOU    3  C   LEU A   1     4792   6014   5285    633    268    472       C  \\nATOM      4  O   LEU A   1      73.902  43.890  11.599  1.00 41.66           O  \\nANISOU    4  O   LEU A   1     4694   6022   5115    649    226    513       O  \\nATOM      5  CB  LEU A   1      71.353  42.030  11.114  1.00 27.18           C  \\nANISOU    5  CB  LEU A   1     2946   3884   3496    590    347    537       C  \\nATOM      6  CG  LEU A   1      70.770  42.663   9.833  1.00 42.92           C  \\nANISOU    6  CG  LEU A   1     4936   5888   5485    480    322    426       C  \\nATOM      7  CD1 LEU A   1      70.977  41.760   8.619  1.00 23.59           C  \\nANISOU    7  CD1 LEU A   1     2480   3368   3116    468    349    332       C  \\nATOM      8  CD2 LEU A   1      69.287  43.077   9.964  1.00 22.69           C  \\nANISOU    8  CD2 LEU A   1     2395   3288   2936    406    324    436       C  \\nATOM      9  N   LYS A   2      73.932  43.201   9.451  1.00 29.48           N  \\nANISOU    9  N   LYS A   2     3140   4399   3661    580    265    374       N  \\nATOM     10  CA  LYS A   2      74.511  44.433   8.925  1.00 42.24           C  \\nANISOU   10  CA  LYS A   2     4722   6135   5192    521    218    322       C  \\nATOM     11  C   LYS A   2      73.568  45.067   7.904  1.00 34.75           C  \\nANISOU   11  C   LYS A   2     3798   5172   4232    415    209    261       C  \\nATOM     12  O   LYS A   2      73.049  44.389   7.016  1.00 41.19           O  \\nANISOU   12  O   LYS A   2     4630   5918   5102    392    239    205       O  \\nATOM     13  CB  LYS A   2      75.874  44.161   8.268  1.00 33.86           C  \\nANISOU   13  CB  LYS A   2     3603   5134   4127    560    225    271       C  \\nATOM     14  CG  LYS A   2      77.015  43.863   9.236  1.00 35.77           C  \\nANISOU   14  CG  LYS A   2     3799   5436   4356    664    212    325       C  \\nATOM     15  CD  LYS A   2      78.349  44.239   8.618  1.00 54.23           C  \\nANISOU   15  CD  LYS A   2     6059   7885   6660    666    199    269       C  \\nATOM     16  CE  LYS A   2      79.518  43.602   9.355  1.00 65.63           C  \\nANISOU   16  CE  LYS A   2     7446   9378   8115    788    194    307       C  \\nATOM     17  NZ  LYS A   2      79.751  42.175   8.963  1.00 53.02           N  \\nANISOU   17  NZ  LYS A   2     5853   7688   6604    877    251    297       N  \\nATOM     18  N   CYS A   3      73.352  46.368   8.023  1.00 32.68           N  \\nANISOU   18  N   CYS A   3     3538   4977   3902    356    167    266       N  \\nATOM     19  CA  CYS A   3      72.522  47.081   7.055  1.00 26.89           C  \\nANISOU   19  CA  CYS A   3     2826   4243   3149    267    153    220       C  \\nATOM     20  C   CYS A   3      73.237  48.308   6.528  1.00 33.69           C  \\nANISOU   20  C   CYS A   3     3660   5201   3938    216    122    198       C  \\nATOM     21  O   CYS A   3      74.030  48.927   7.244  1.00 39.81           O  \\nANISOU   21  O   CYS A   3     4407   6039   4681    230     97    225       O  \\nATOM     22  CB  CYS A   3      71.218  47.546   7.705  1.00 31.56           C  \\nANISOU   22  CB  CYS A   3     3455   4793   3742    238    138    260       C  \\nATOM     23  SG  CYS A   3      70.246  46.255   8.484  1.00 29.15           S  \\nANISOU   23  SG  CYS A   3     3178   4372   3527    283    184    308       S  \\nATOM     24  N   HIS A   4      72.950  48.671   5.279  1.00 23.00           N  \\nANISOU   24  N   HIS A   4     2315   3863   2561    156    124    151       N  \\nATOM     25  CA  HIS A   4      73.320  49.994   4.793  1.00 27.83           C  \\nANISOU   25  CA  HIS A   4     2915   4548   3111     95    100    152       C  \\nATOM     26  C   HIS A   4      72.627  51.054   5.666  1.00 31.22           C  \\nANISOU   26  C   HIS A   4     3371   4963   3527     67     59    197       C  \\nATOM     27  O   HIS A   4      71.455  50.903   6.009  1.00 39.81           O  \\nANISOU   27  O   HIS A   4     4496   5993   4637     69     53    211       O  \\nATOM     28  CB  HIS A   4      72.923  50.151   3.328  1.00 20.13           C  \\nANISOU   28  CB  HIS A   4     1956   3591   2103     47    110    109       C  \\nATOM     29  CG  HIS A   4      73.638  49.214   2.394  1.00 33.21           C  \\nANISOU   29  CG  HIS A   4     3584   5274   3759     75    151     49       C  \\nATOM     30  ND1 HIS A   4      75.003  49.242   2.210  1.00 33.39           N  \\nANISOU   30  ND1 HIS A   4     3554   5370   3763     92    176     42       N  \\nATOM     31  CD2 HIS A   4      73.174  48.231   1.586  1.00 23.47           C  \\nANISOU   31  CD2 HIS A   4     2365   4008   2544     89    173    -17       C  \\nATOM     32  CE1 HIS A   4      75.349  48.317   1.334  1.00 35.89           C  \\nANISOU   32  CE1 HIS A   4     3856   5698   4081    123    216    -22       C  \\nATOM     33  NE2 HIS A   4      74.258  47.686   0.942  1.00 35.86           N  \\nANISOU   33  NE2 HIS A   4     3896   5628   4100    122    212    -64       N  \\nATOM     34  N   ASN A   5      73.339  52.112   6.047  1.00 26.68           N  \\nANISOU   34  N   ASN A   5     2774   4440   2923     42     34    213       N  \\nATOM     35  CA  ASN A   5      72.739  53.125   6.926  1.00 34.14           C  \\nANISOU   35  CA  ASN A   5     3745   5368   3859     22     -5    241       C  \\nATOM     36  C   ASN A   5      72.878  54.585   6.481  1.00 34.73           C  \\nANISOU   36  C   ASN A   5     3823   5462   3910    -50    -27    244       C  \\nATOM     37  O   ASN A   5      72.683  55.497   7.280  1.00 37.63           O  \\nANISOU   37  O   ASN A   5     4202   5819   4277    -63    -61    253       O  \\nATOM     38  CB  ASN A   5      73.268  52.977   8.354  1.00 25.01           C  \\nANISOU   38  CB  ASN A   5     2566   4234   2702     78    -24    257       C  \\nATOM     39  CG  ASN A   5      74.733  53.325   8.470  1.00 39.97           C  \\nANISOU   39  CG  ASN A   5     4396   6204   4584     73    -37    239       C  \\nATOM     40  OD1 ASN A   5      75.518  53.099   7.541  1.00 39.30           O  \\nANISOU   40  OD1 ASN A   5     4275   6155   4504     55    -10    220       O  \\nATOM     41  ND2 ASN A   5      75.116  53.883   9.616  1.00 38.43           N  \\nANISOU   41  ND2 ASN A   5     4183   6046   4374     89    -78    239       N  \\nATOM     42  N   LYS A   6      73.233  54.794   5.217  1.00 40.38           N  \\nANISOU   42  N   LYS A   6     4530   6206   4608    -93     -5    236       N  \\nATOM     43  CA  LYS A   6      73.351  56.129   4.635  1.00 41.59           C  \\nANISOU   43  CA  LYS A   6     4691   6367   4744   -163    -13    257       C  \\nATOM     44  C   LYS A   6      72.689  56.093   3.270  1.00 31.47           C  \\nANISOU   44  C   LYS A   6     3442   5086   3428   -184      6    265       C  \\nATOM     45  O   LYS A   6      72.413  55.016   2.736  1.00 37.14           O  \\nANISOU   45  O   LYS A   6     4162   5812   4137   -151     25    235       O  \\nATOM     46  CB  LYS A   6      74.820  56.507   4.441  1.00 43.17           C  \\nANISOU   46  CB  LYS A   6     4828   6628   4946   -198      5    252       C  \\nATOM     47  CG  LYS A   6      75.703  56.308   5.656  1.00 42.18           C  \\nANISOU   47  CG  LYS A   6     4649   6533   4845   -167    -17    230       C  \\nATOM     48  CD  LYS A   6      75.450  57.358   6.714  1.00 32.74           C  \\nANISOU   48  CD  LYS A   6     3468   5305   3666   -188    -66    229       C  \\nATOM     49  CE  LYS A   6      76.394  57.151   7.892  1.00 57.53           C  \\nANISOU   49  CE  LYS A   6     6547   8498   6814   -152    -96    198       C  \\nATOM     50  NZ  LYS A   6      76.271  58.233   8.902  1.00 66.68           N  \\nANISOU   50  NZ  LYS A   6     7713   9638   7984   -176   -148    176       N  \\nATOM     51  N   LEU A   7      72.461  57.248   2.666  1.00 31.90           N  \\nANISOU   51  N   LEU A   7     3521   5134   3464   -235      0    302       N  \\nATOM     52  CA  LEU A   7      71.880  57.227   1.320  1.00 40.36           C  \\nANISOU   52  CA  LEU A   7     4623   6229   4484   -244     13    315       C  \\nATOM     53  C   LEU A   7      72.907  57.232   0.182  1.00 29.90           C  \\nANISOU   53  C   LEU A   7     3268   4982   3111   -271     63    323       C  \\nATOM     54  O   LEU A   7      72.543  57.240  -0.992  1.00 40.62           O  \\nANISOU   54  O   LEU A   7     4648   6379   4406   -275     76    335       O  \\nATOM     55  CB  LEU A   7      70.797  58.289   1.132  1.00 49.35           C  \\nANISOU   55  CB  LEU A   7     5813   7321   5615   -262    -20    361       C  \\nATOM     56  CG  LEU A   7      70.969  59.723   1.603  1.00 49.86           C  \\nANISOU   56  CG  LEU A   7     5893   7338   5714   -304    -35    408       C  \\nATOM     57  CD1 LEU A   7      70.749  59.814   3.106  1.00 73.38           C  \\nANISOU   57  CD1 LEU A   7     8870  10263   8748   -283    -68    379       C  \\nATOM     58  CD2 LEU A   7      72.340  60.256   1.194  1.00 31.68           C  \\nANISOU   58  CD2 LEU A   7     3553   5072   3411   -360      5    433       C  \\nATOM     59  N   VAL A   8      74.188  57.225   0.548  1.00 27.34           N  \\nANISOU   59  N   VAL A   8     2886   4690   2811   -287     89    316       N  \\nATOM     60  CA  VAL A   8      75.260  56.924  -0.388  1.00 35.76           C  \\nANISOU   60  CA  VAL A   8     3907   5842   3839   -298    147    309       C  \\nATOM     61  C   VAL A   8      75.449  55.401  -0.335  1.00 41.47           C  \\nANISOU   61  C   VAL A   8     4604   6590   4565   -230    161    238       C  \\nATOM     62  O   VAL A   8      74.969  54.758   0.604  1.00 36.62           O  \\nANISOU   62  O   VAL A   8     3999   5919   3994   -187    129    211       O  \\nATOM     63  CB  VAL A   8      76.562  57.675  -0.011  1.00 42.98           C  \\nANISOU   63  CB  VAL A   8     4757   6782   4793   -351    169    332       C  \\nATOM     64  CG1 VAL A   8      76.328  59.185  -0.015  1.00 34.60           C  \\nANISOU   64  CG1 VAL A   8     3726   5668   3752   -422    157    399       C  \\nATOM     65  CG2 VAL A   8      77.092  57.210   1.341  1.00 39.93           C  \\nANISOU   65  CG2 VAL A   8     4322   6382   4466   -318    138    288       C  \\nATOM     66  N   PRO A   9      76.118  54.808  -1.343  1.00 38.91           N  \\nANISOU   66  N   PRO A   9     4248   6343   4193   -216    214    209       N  \\nATOM     67  CA  PRO A   9      76.303  53.346  -1.332  1.00 37.97           C  \\nANISOU   67  CA  PRO A   9     4108   6232   4088   -146    230    133       C  \\nATOM     68  C   PRO A   9      77.274  52.822  -0.252  1.00 45.56           C  \\nANISOU   68  C   PRO A   9     5006   7188   5115   -108    232    116       C  \\nATOM     69  O   PRO A   9      77.885  53.622   0.455  1.00 34.52           O  \\nANISOU   69  O   PRO A   9     3572   5798   3745   -141    218    153       O  \\nATOM     70  CB  PRO A   9      76.889  53.047  -2.729  1.00 40.50           C  \\nANISOU   70  CB  PRO A   9     4405   6650   4332   -142    292    104       C  \\nATOM     71  CG  PRO A   9      76.612  54.253  -3.555  1.00 39.43           C  \\nANISOU   71  CG  PRO A   9     4302   6552   4128   -204    300    173       C  \\nATOM     72  CD  PRO A   9      76.614  55.415  -2.593  1.00 35.73           C  \\nANISOU   72  CD  PRO A   9     3836   6022   3719   -257    266    244       C  \\nATOM     73  N   PHE A  10      77.367  51.493  -0.130  1.00 32.23           N  \\nANISOU   73  N   PHE A  10     3306   5483   3455    -35    246     59       N  \\nATOM     74  CA  PHE A  10      78.455  50.785   0.568  1.00 36.03           C  \\nANISOU   74  CA  PHE A  10     3720   5984   3984     25    260     40       C  \\nATOM     75  C   PHE A  10      78.520  50.847   2.093  1.00 38.05           C  \\nANISOU   75  C   PHE A  10     3965   6197   4296     51    213     74       C  \\nATOM     76  O   PHE A  10      78.621  49.808   2.754  1.00 39.95           O  \\nANISOU   76  O   PHE A  10     4198   6402   4580    130    211     60       O  \\nATOM     77  CB  PHE A  10      79.825  51.160   0.004  1.00 44.76           C  \\nANISOU   77  CB  PHE A  10     4743   7197   5065      4    308     39       C  \\nATOM     78  CG  PHE A  10      80.953  50.366   0.602  1.00 43.56           C  \\nANISOU   78  CG  PHE A  10     4511   7079   4960     77    322     12       C  \\nATOM     79  CD1 PHE A  10      81.148  49.035   0.244  1.00 50.97           C  \\nANISOU   79  CD1 PHE A  10     5441   8010   5916    163    358    -48       C  \\nATOM     80  CD2 PHE A  10      81.816  50.940   1.517  1.00 39.34           C  \\nANISOU   80  CD2 PHE A  10     3907   6584   4458     65    296     41       C  \\nATOM     81  CE1 PHE A  10      82.185  48.287   0.790  1.00 45.81           C  \\nANISOU   81  CE1 PHE A  10     4713   7385   5309    245    370    -66       C  \\nATOM     82  CE2 PHE A  10      82.856  50.199   2.067  1.00 50.28           C  \\nANISOU   82  CE2 PHE A  10     5209   8013   5881    143    302     19       C  \\nATOM     83  CZ  PHE A  10      83.040  48.869   1.700  1.00 48.60           C  \\nANISOU   83  CZ  PHE A  10     4991   7789   5684    238    340    -29       C  \\nATOM     84  N   LEU A  11      78.535  52.060   2.634  1.00 26.30           N  \\nANISOU   84  N   LEU A  11     2475   4716   2804     -9    178    117       N  \\nATOM     85  CA  LEU A  11      78.553  52.275   4.080  1.00 37.67           C  \\nANISOU   85  CA  LEU A  11     3907   6131   4276     13    126    139       C  \\nATOM     86  C   LEU A  11      77.528  51.419   4.839  1.00 39.89           C  \\nANISOU   86  C   LEU A  11     4247   6329   4581     77    107    147       C  \\nATOM     87  O   LEU A  11      76.385  51.250   4.401  1.00 32.57           O  \\nANISOU   87  O   LEU A  11     3383   5341   3650     63    110    146       O  \\nATOM     88  CB  LEU A  11      78.311  53.753   4.372  1.00 32.16           C  \\nANISOU   88  CB  LEU A  11     3224   5425   3570    -69     90    169       C  \\nATOM     89  CG  LEU A  11      79.536  54.619   4.673  1.00 51.12           C  \\nANISOU   89  CG  LEU A  11     5543   7893   5987   -117     81    167       C  \\nATOM     90  CD1 LEU A  11      80.827  54.033   4.102  1.00 32.85           C  \\nANISOU   90  CD1 LEU A  11     3139   5668   3676    -95    129    142       C  \\nATOM     91  CD2 LEU A  11      79.302  56.041   4.171  1.00 42.87           C  \\nANISOU   91  CD2 LEU A  11     4521   6828   4939   -220     81    196       C  \\nATOM     92  N   SER A  12      77.943  50.871   5.972  1.00 27.07           N  \\nANISOU   92  N   SER A  12     2596   4708   2981    148     87    159       N  \\nATOM     93  CA  SER A  12      77.050  50.040   6.767  1.00 30.77           C  \\nANISOU   93  CA  SER A  12     3116   5099   3475    210     81    184       C  \\nATOM     94  C   SER A  12      77.434  50.038   8.234  1.00 34.34           C  \\nANISOU   94  C   SER A  12     3546   5578   3924    270     42    219       C  \\nATOM     95  O   SER A  12      78.502  50.511   8.621  1.00 38.79           O  \\nANISOU   95  O   SER A  12     4043   6223   4471    273     16    210       O  \\nATOM     96  CB  SER A  12      77.037  48.603   6.260  1.00 25.87           C  \\nANISOU   96  CB  SER A  12     2502   4433   2896    274    128    162       C  \\nATOM     97  OG  SER A  12      78.293  47.988   6.475  1.00 31.62           O  \\nANISOU   97  OG  SER A  12     3162   5213   3638    345    141    155       O  \\nATOM     98  N   LYS A  13      76.534  49.497   9.040  1.00 24.30           N  \\nANISOU   98  N   LYS A  13     2326   4241   2665    318     41    259       N  \\nATOM     99  CA  LYS A  13      76.757  49.330  10.463  1.00 32.10           C  \\nANISOU   99  CA  LYS A  13     3306   5257   3635    393     11    303       C  \\nATOM    100  C   LYS A  13      76.226  47.969  10.849  1.00 34.57           C  \\nANISOU  100  C   LYS A  13     3656   5490   3989    477     51    352       C  \\nATOM    101  O   LYS A  13      75.394  47.385  10.154  1.00 39.29           O  \\nANISOU  101  O   LYS A  13     4295   5998   4634    455     93    344       O  \\nATOM    102  CB  LYS A  13      76.017  50.406  11.261  1.00 20.10           C  \\nANISOU  102  CB  LYS A  13     1821   3743   2074    355    -31    316       C  \\nATOM    103  CG  LYS A  13      74.488  50.275  11.217  1.00 38.96           C  \\nANISOU  103  CG  LYS A  13     4284   6039   4481    334     -7    341       C  \\nATOM    104  CD  LYS A  13      73.786  51.339  12.086  1.00 51.84           C  \\nANISOU  104  CD  LYS A  13     5946   7683   6070    311    -45    349       C  \\nATOM    105  CE  LYS A  13      74.214  51.237  13.552  1.00 61.13           C  \\nANISOU  105  CE  LYS A  13     7107   8923   7197    395    -74    380       C  \\nATOM    106  NZ  LYS A  13      73.520  52.226  14.425  1.00 63.57           N  \\nANISOU  106  NZ  LYS A  13     7446   9249   7458    382   -107    374       N  \\nATOM    107  N   THR A  14      76.719  47.452  11.956  1.00 27.82           N  \\nANISOU  107  N   THR A  14     2783   4668   3119    574     39    404       N  \\nATOM    108  CA  THR A  14      76.116  46.278  12.546  1.00 25.89           C  \\nANISOU  108  CA  THR A  14     2584   4340   2914    654     81    476       C  \\nATOM    109  C   THR A  14      74.960  46.746  13.430  1.00 34.21           C  \\nANISOU  109  C   THR A  14     3691   5373   3933    639     74    523       C  \\nATOM    110  O   THR A  14      75.137  47.628  14.286  1.00 30.42           O  \\nANISOU  110  O   THR A  14     3201   4981   3378    644     23    527       O  \\nATOM    111  CB  THR A  14      77.110  45.513  13.445  1.00 44.92           C  \\nANISOU  111  CB  THR A  14     4956   6800   5312    783     73    533       C  \\nATOM    112  OG1 THR A  14      78.187  44.984  12.659  1.00 27.13           O  \\nANISOU  112  OG1 THR A  14     2645   4565   3098    813     87    489       O  \\nATOM    113  CG2 THR A  14      76.392  44.368  14.184  1.00 33.14           C  \\nANISOU  113  CG2 THR A  14     3520   5211   3860    867    125    632       C  \\nATOM    114  N   CYS A  15      73.789  46.152  13.223  1.00 28.76           N  \\nANISOU  114  N   CYS A  15     3054   4572   3301    619    125    550       N  \\nATOM    115  CA  CYS A  15      72.599  46.481  14.005  1.00 38.17           C  \\nANISOU  115  CA  CYS A  15     4292   5740   4472    607    133    598       C  \\nATOM    116  C   CYS A  15      72.734  46.151  15.489  1.00 34.51           C  \\nANISOU  116  C   CYS A  15     3837   5320   3954    711    136    692       C  \\nATOM    117  O   CYS A  15      73.257  45.088  15.849  1.00 27.73           O  \\nANISOU  117  O   CYS A  15     2974   4441   3122    803    165    756       O  \\nATOM    118  CB  CYS A  15      71.393  45.728  13.454  1.00 41.13           C  \\nANISOU  118  CB  CYS A  15     4704   5986   4939    568    194    608       C  \\nATOM    119  SG  CYS A  15      71.085  46.022  11.724  1.00 34.82           S  \\nANISOU  119  SG  CYS A  15     3898   5147   4185    458    188    499       S  \\nATOM    120  N   PRO A  16      72.226  47.056  16.346  1.00 32.96           N  \\nANISOU  120  N   PRO A  16     3657   5186   3679    705    107    703       N  \\nATOM    121  CA  PRO A  16      72.130  46.844  17.796  1.00 23.81           C  \\nANISOU  121  CA  PRO A  16     2516   4084   2447    803    113    793       C  \\nATOM    122  C   PRO A  16      71.205  45.670  18.117  1.00 36.71           C  \\nANISOU  122  C   PRO A  16     4193   5610   4146    842    203    899       C  \\nATOM    123  O   PRO A  16      70.332  45.334  17.307  1.00 27.82           O  \\nANISOU  123  O   PRO A  16     3084   4370   3117    769    250    882       O  \\nATOM    124  CB  PRO A  16      71.472  48.143  18.311  1.00 28.54           C  \\nANISOU  124  CB  PRO A  16     3130   4746   2969    758     76    752       C  \\nATOM    125  CG  PRO A  16      71.512  49.117  17.162  1.00 38.79           C  \\nANISOU  125  CG  PRO A  16     4411   6029   4299    645     37    644       C  \\nATOM    126  CD  PRO A  16      71.560  48.305  15.917  1.00 27.72           C  \\nANISOU  126  CD  PRO A  16     3003   4532   2998    605     76    632       C  \\nATOM    127  N   GLU A  17      71.391  45.056  19.283  1.00 32.45           N  \\nANISOU  127  N   GLU A  17     3667   5107   3555    956    226   1009       N  \\nATOM    128  CA  GLU A  17      70.459  44.035  19.760  1.00 47.44           C  \\nANISOU  128  CA  GLU A  17     5607   6905   5511    992    322   1130       C  \\nATOM    129  C   GLU A  17      69.031  44.536  19.673  1.00 44.11           C  \\nANISOU  129  C   GLU A  17     5209   6439   5113    904    358   1114       C  \\nATOM    130  O   GLU A  17      68.741  45.689  20.019  1.00 40.77           O  \\nANISOU  130  O   GLU A  17     4784   6107   4600    877    312   1062       O  \\nATOM    131  CB  GLU A  17      70.761  43.649  21.206  1.00 30.45           C  \\nANISOU  131  CB  GLU A  17     3473   4839   3257   1129    336   1259       C  \\nATOM    132  CG  GLU A  17      72.147  43.085  21.379  1.00 53.32           C  \\nANISOU  132  CG  GLU A  17     6341   7788   6130   1236    298   1287       C  \\nATOM    133  CD  GLU A  17      72.422  42.619  22.797  1.00 59.42           C  \\nANISOU  133  CD  GLU A  17     7133   8650   6795   1386    311   1430       C  \\nATOM    134  OE1 GLU A  17      73.597  42.645  23.199  1.00 71.39           O  \\nANISOU  134  OE1 GLU A  17     8612  10283   8230   1480    243   1429       O  \\nATOM    135  OE2 GLU A  17      71.484  42.228  23.509  1.00 49.36           O  \\nANISOU  135  OE2 GLU A  17     5905   7340   5511   1414    390   1545       O  \\nATOM    136  N   GLY A  18      68.139  43.671  19.209  1.00 43.03           N  \\nANISOU  136  N   GLY A  18     5087   6159   5103    860    438   1151       N  \\nATOM    137  CA  GLY A  18      66.740  44.038  19.111  1.00 41.84           C  \\nANISOU  137  CA  GLY A  18     4944   5965   4988    779    476   1140       C  \\nATOM    138  C   GLY A  18      66.295  44.479  17.726  1.00 42.56           C  \\nANISOU  138  C   GLY A  18     5015   5999   5158    657    445   1013       C  \\nATOM    139  O   GLY A  18      65.120  44.330  17.384  1.00 42.25           O  \\nANISOU  139  O   GLY A  18     4972   5882   5198    589    490   1007       O  \\nATOM    140  N   LYS A  19      67.216  45.026  16.932  1.00 42.12           N  \\nANISOU  140  N   LYS A  19     4940   5988   5074    632    371    915       N  \\nATOM    141  CA  LYS A  19      66.902  45.423  15.556  1.00 37.08           C  \\nANISOU  141  CA  LYS A  19     4287   5309   4495    529    341    803       C  \\nATOM    142  C   LYS A  19      67.416  44.406  14.542  1.00 37.63           C  \\nANISOU  142  C   LYS A  19     4346   5289   4662    517    360    767       C  \\nATOM    143  O   LYS A  19      68.577  44.441  14.148  1.00 51.95           O  \\nANISOU  143  O   LYS A  19     6144   7146   6448    542    323    727       O  \\nATOM    144  CB  LYS A  19      67.470  46.807  15.247  1.00 32.35           C  \\nANISOU  144  CB  LYS A  19     3674   4813   3803    496    257    719       C  \\nATOM    145  CG  LYS A  19      67.120  47.860  16.291  1.00 24.74           C  \\nANISOU  145  CG  LYS A  19     2722   3939   2741    517    231    736       C  \\nATOM    146  CD  LYS A  19      67.587  49.258  15.880  1.00 33.80           C  \\nANISOU  146  CD  LYS A  19     3857   5158   3827    470    151    645       C  \\nATOM    147  CE  LYS A  19      67.132  50.311  16.892  1.00 42.58           C  \\nANISOU  147  CE  LYS A  19     4982   6342   4854    489    128    644       C  \\nATOM    148  NZ  LYS A  19      67.356  51.706  16.407  1.00 37.28           N  \\nANISOU  148  NZ  LYS A  19     4305   5706   4153    429     60    554       N  \\nATOM    149  N   ASN A  20      66.543  43.502  14.118  1.00 38.77           N  \\nANISOU  149  N   ASN A  20     4494   5311   4925    478    419    772       N  \\nATOM    150  CA  ASN A  20      66.929  42.444  13.197  1.00 36.11           C  \\nANISOU  150  CA  ASN A  20     4152   4876   4694    470    443    726       C  \\nATOM    151  C   ASN A  20      66.331  42.613  11.800  1.00 44.74           C  \\nANISOU  151  C   ASN A  20     5227   5932   5839    369    419    602       C  \\nATOM    152  O   ASN A  20      66.145  41.626  11.073  1.00 34.02           O  \\nANISOU  152  O   ASN A  20     3865   4469   4593    344    453    555       O  \\nATOM    153  CB  ASN A  20      66.512  41.085  13.754  1.00 45.81           C  \\nANISOU  153  CB  ASN A  20     5396   5971   6039    509    532    820       C  \\nATOM    154  CG  ASN A  20      67.099  40.810  15.110  1.00 48.77           C  \\nANISOU  154  CG  ASN A  20     5792   6385   6354    624    559    957       C  \\nATOM    155  OD1 ASN A  20      68.322  40.818  15.287  1.00 58.37           O  \\nANISOU  155  OD1 ASN A  20     7004   7667   7508    702    524    965       O  \\nATOM    156  ND2 ASN A  20      66.231  40.575  16.089  1.00 55.89           N  \\nANISOU  156  ND2 ASN A  20     6711   7257   7268    640    622   1068       N  \\nATOM    157  N   LEU A  21      66.021  43.855  11.436  1.00 34.22           N  \\nANISOU  157  N   LEU A  21     3886   4688   4426    314    361    549       N  \\nATOM    158  CA  LEU A  21      65.571  44.177  10.084  1.00 40.39           C  \\nANISOU  158  CA  LEU A  21     4652   5468   5225    232    325    438       C  \\nATOM    159  C   LEU A  21      66.333  45.369   9.531  1.00 42.11           C  \\nANISOU  159  C   LEU A  21     4866   5799   5334    217    258    387       C  \\nATOM    160  O   LEU A  21      66.586  46.339  10.249  1.00 38.23           O  \\nANISOU  160  O   LEU A  21     4381   5386   4760    237    228    427       O  \\nATOM    161  CB  LEU A  21      64.082  44.519  10.064  1.00 34.00           C  \\nANISOU  161  CB  LEU A  21     3832   4637   4449    168    328    431       C  \\nATOM    162  CG  LEU A  21      63.075  43.393  10.283  1.00 51.02           C  \\nANISOU  162  CG  LEU A  21     5975   6670   6739    146    397    457       C  \\nATOM    163  CD1 LEU A  21      61.672  43.991  10.350  1.00 33.60           C  \\nANISOU  163  CD1 LEU A  21     3743   4478   4544     88    390    451       C  \\nATOM    164  CD2 LEU A  21      63.199  42.313   9.189  1.00 37.76           C  \\nANISOU  164  CD2 LEU A  21     4284   4898   5163    114    409    365       C  \\nATOM    165  N   CYS A  22      66.689  45.290   8.252  1.00 29.68           N  \\nANISOU  165  N   CYS A  22     3281   4233   3762    182    237    298       N  \\nATOM    166  CA  CYS A  22      67.186  46.443   7.527  1.00 19.20           C  \\nANISOU  166  CA  CYS A  22     1948   3004   2341    151    183    253       C  \\nATOM    167  C   CYS A  22      65.973  47.164   6.951  1.00 34.70           C  \\nANISOU  167  C   CYS A  22     3913   4976   4295     85    151    221       C  \\nATOM    168  O   CYS A  22      64.951  46.543   6.641  1.00 24.20           O  \\nANISOU  168  O   CYS A  22     2575   3583   3036     55    167    191       O  \\nATOM    169  CB  CYS A  22      68.139  46.008   6.397  1.00 19.50           C  \\nANISOU  169  CB  CYS A  22     1973   3062   2375    152    184    180       C  \\nATOM    170  SG  CYS A  22      69.615  45.092   6.930  1.00 29.65           S  \\nANISOU  170  SG  CYS A  22     3244   4341   3682    241    220    208       S  \\nATOM    171  N   TYR A  23      66.069  48.476   6.811  1.00 36.88           N  \\nANISOU  171  N   TYR A  23     4196   5327   4490     63    107    225       N  \\nATOM    172  CA  TYR A  23      64.989  49.218   6.170  1.00 41.02           C  \\nANISOU  172  CA  TYR A  23     4720   5866   4998     14     71    199       C  \\nATOM    173  C   TYR A  23      65.551  50.199   5.140  1.00 39.04           C  \\nANISOU  173  C   TYR A  23     4475   5689   4667    -14     31    170       C  \\nATOM    174  O   TYR A  23      66.693  50.641   5.256  1.00 33.21           O  \\nANISOU  174  O   TYR A  23     3739   4995   3884     -3     29    187       O  \\nATOM    175  CB  TYR A  23      64.111  49.945   7.211  1.00 22.36           C  \\nANISOU  175  CB  TYR A  23     2365   3499   2633     21     65    254       C  \\nATOM    176  CG  TYR A  23      64.723  51.214   7.755  1.00 34.22           C  \\nANISOU  176  CG  TYR A  23     3883   5058   4061     33     35    287       C  \\nATOM    177  CD1 TYR A  23      65.565  51.175   8.864  1.00 35.21           C  \\nANISOU  177  CD1 TYR A  23     4013   5200   4166     79     48    327       C  \\nATOM    178  CD2 TYR A  23      64.473  52.452   7.158  1.00 27.40           C  \\nANISOU  178  CD2 TYR A  23     3030   4230   3152      1    -10    274       C  \\nATOM    179  CE1 TYR A  23      66.136  52.327   9.368  1.00 39.71           C  \\nANISOU  179  CE1 TYR A  23     4592   5820   4676     84     14    337       C  \\nATOM    180  CE2 TYR A  23      65.052  53.615   7.655  1.00 40.83           C  \\nANISOU  180  CE2 TYR A  23     4747   5964   4805      5    -35    296       C  \\nATOM    181  CZ  TYR A  23      65.883  53.543   8.761  1.00 43.79           C  \\nANISOU  181  CZ  TYR A  23     5119   6354   5165     42    -24    318       C  \\nATOM    182  OH  TYR A  23      66.456  54.685   9.273  1.00 33.01           O  \\nANISOU  182  OH  TYR A  23     3763   5020   3760     40    -55    321       O  \\nATOM    183  N   LYS A  24      64.750  50.510   4.126  1.00 38.59           N  \\nANISOU  183  N   LYS A  24     4418   5651   4595    -51      1    131       N  \\nATOM    184  CA  LYS A  24      65.086  51.538   3.144  1.00 39.22           C  \\nANISOU  184  CA  LYS A  24     4508   5801   4592    -75    -33    125       C  \\nATOM    185  C   LYS A  24      63.851  52.367   2.827  1.00 43.17           C  \\nANISOU  185  C   LYS A  24     5014   6312   5077    -93    -76    134       C  \\nATOM    186  O   LYS A  24      62.806  51.831   2.430  1.00 38.18           O  \\nANISOU  186  O   LYS A  24     4362   5664   4479   -104    -88     92       O  \\nATOM    187  CB  LYS A  24      65.628  50.937   1.839  1.00 28.26           C  \\nANISOU  187  CB  LYS A  24     3112   4454   3172    -84    -26     60       C  \\nATOM    188  CG  LYS A  24      65.805  51.988   0.734  1.00 28.04           C  \\nANISOU  188  CG  LYS A  24     3097   4506   3049   -107    -55     67       C  \\nATOM    189  CD  LYS A  24      66.568  51.463  -0.492  1.00 26.01           C  \\nANISOU  189  CD  LYS A  24     2832   4312   2737   -107    -37      8       C  \\nATOM    190  CE  LYS A  24      65.763  50.417  -1.256  1.00 29.62           C  \\nANISOU  190  CE  LYS A  24     3277   4764   3215   -108    -49    -87       C  \\nATOM    191  NZ  LYS A  24      66.454  49.950  -2.469  1.00 23.86           N  \\nANISOU  191  NZ  LYS A  24     2541   4105   2419   -101    -33   -157       N  \\nATOM    192  N   MET A  25      63.970  53.676   3.008  1.00 26.91           N  \\nANISOU  192  N   MET A  25     2975   4274   2974    -96    -99    185       N  \\nATOM    193  CA  MET A  25      62.890  54.571   2.643  1.00 29.93           C  \\nANISOU  193  CA  MET A  25     3365   4668   3339   -102   -141    201       C  \\nATOM    194  C   MET A  25      63.195  55.220   1.319  1.00 35.39           C  \\nANISOU  194  C   MET A  25     4073   5421   3952   -117   -166    205       C  \\nATOM    195  O   MET A  25      64.326  55.655   1.085  1.00 31.93           O  \\nANISOU  195  O   MET A  25     3651   5009   3474   -129   -149    230       O  \\nATOM    196  CB  MET A  25      62.694  55.652   3.688  1.00 24.89           C  \\nANISOU  196  CB  MET A  25     2745   4001   2711    -87   -150    254       C  \\nATOM    197  CG  MET A  25      62.223  55.122   5.027  1.00 41.82           C  \\nANISOU  197  CG  MET A  25     4875   6100   4914    -62   -124    259       C  \\nATOM    198  SD  MET A  25      61.769  56.459   6.146  1.00 57.53           S  \\nANISOU  198  SD  MET A  25     6886   8071   6904    -36   -139    300       S  \\nATOM    199  CE  MET A  25      61.411  55.518   7.633  1.00 43.19           C  \\nANISOU  199  CE  MET A  25     5050   6227   5134     -2    -91    309       C  \\nATOM    200  N   THR A  26      62.176  55.283   0.465  1.00 34.22           N  \\nANISOU  200  N   THR A  26     3916   5305   3782   -116   -205    185       N  \\nATOM    201  CA  THR A  26      62.264  55.979  -0.811  1.00 34.35           C  \\nANISOU  201  CA  THR A  26     3951   5391   3708   -118   -234    204       C  \\nATOM    202  C   THR A  26      61.033  56.853  -0.978  1.00 37.37           C  \\nANISOU  202  C   THR A  26     4336   5779   4083    -97   -286    238       C  \\nATOM    203  O   THR A  26      59.988  56.581  -0.370  1.00 29.32           O  \\nANISOU  203  O   THR A  26     3287   4727   3128    -86   -302    215       O  \\nATOM    204  CB  THR A  26      62.297  54.985  -1.987  1.00 30.61           C  \\nANISOU  204  CB  THR A  26     3458   4984   3187   -123   -239    125       C  \\nATOM    205  OG1 THR A  26      61.191  54.078  -1.880  1.00 29.13           O  \\nANISOU  205  OG1 THR A  26     3230   4775   3061   -122   -262     52       O  \\nATOM    206  CG2 THR A  26      63.591  54.184  -1.968  1.00 22.01           C  \\nANISOU  206  CG2 THR A  26     2367   3896   2100   -133   -185     92       C  \\nATOM    207  N   LEU A  27      61.146  57.903  -1.791  1.00 25.60           N  \\nANISOU  207  N   LEU A  27     2878   4331   2520    -88   -308    299       N  \\nATOM    208  CA  LEU A  27      59.953  58.608  -2.249  1.00 41.50           C  \\nANISOU  208  CA  LEU A  27     4889   6368   4510    -54   -366    328       C  \\nATOM    209  C   LEU A  27      59.214  57.708  -3.236  1.00 45.35           C  \\nANISOU  209  C   LEU A  27     5336   6938   4956    -46   -408    249       C  \\nATOM    210  O   LEU A  27      59.832  57.146  -4.148  1.00 27.98           O  \\nANISOU  210  O   LEU A  27     3139   4806   2686    -58   -398    209       O  \\nATOM    211  CB  LEU A  27      60.326  59.913  -2.943  1.00 28.98           C  \\nANISOU  211  CB  LEU A  27     3354   4803   2855    -41   -374    427       C  \\nATOM    212  CG  LEU A  27      60.963  60.998  -2.081  1.00 28.57           C  \\nANISOU  212  CG  LEU A  27     3341   4662   2852    -53   -343    500       C  \\nATOM    213  CD1 LEU A  27      61.117  62.244  -2.928  1.00 24.57           C  \\nANISOU  213  CD1 LEU A  27     2882   4167   2287    -40   -352    603       C  \\nATOM    214  CD2 LEU A  27      60.108  61.274  -0.862  1.00 19.89           C  \\nANISOU  214  CD2 LEU A  27     2228   3485   1842    -30   -358    489       C  \\nATOM    215  N   MET A  28      57.902  57.570  -3.062  1.00 40.64           N  \\nANISOU  215  N   MET A  28     4695   6342   4404    -26   -453    216       N  \\nATOM    216  CA  MET A  28      57.122  56.688  -3.934  1.00 43.96           C  \\nANISOU  216  CA  MET A  28     5063   6839   4800    -26   -502    122       C  \\nATOM    217  C   MET A  28      57.336  56.995  -5.413  1.00 43.79           C  \\nANISOU  217  C   MET A  28     5063   6937   4638     -2   -542    130       C  \\nATOM    218  O   MET A  28      57.349  56.086  -6.249  1.00 40.73           O  \\nANISOU  218  O   MET A  28     4650   6623   4202    -13   -560     35       O  \\nATOM    219  CB  MET A  28      55.631  56.712  -3.583  1.00 40.30           C  \\nANISOU  219  CB  MET A  28     4537   6371   4404     -6   -551     97       C  \\nATOM    220  CG  MET A  28      55.298  55.906  -2.324  1.00 49.17           C  \\nANISOU  220  CG  MET A  28     5618   7401   5661    -38   -505     56       C  \\nATOM    221  SD  MET A  28      53.537  55.596  -2.096  1.00105.03           S  \\nANISOU  221  SD  MET A  28    12593  14488  12823    -31   -553      0       S  \\nATOM    222  CE  MET A  28      53.537  54.390  -0.763  1.00 35.08           C  \\nANISOU  222  CE  MET A  28     3699   5520   4108    -83   -469    -39       C  \\nATOM    223  N   LYS A  29      57.545  58.270  -5.725  1.00 38.25           N  \\nANISOU  223  N   LYS A  29     4412   6251   3869     31   -550    246       N  \\nATOM    224  CA  LYS A  29      57.769  58.684  -7.112  1.00 57.30           C  \\nANISOU  224  CA  LYS A  29     6854   8782   6135     62   -578    283       C  \\nATOM    225  C   LYS A  29      59.210  58.506  -7.603  1.00 55.13           C  \\nANISOU  225  C   LYS A  29     6621   8537   5788     33   -512    298       C  \\nATOM    226  O   LYS A  29      59.459  58.558  -8.802  1.00 70.00           O  \\nANISOU  226  O   LYS A  29     8522  10537   7539     56   -524    307       O  \\nATOM    227  CB  LYS A  29      57.290  60.124  -7.325  1.00 61.73           C  \\nANISOU  227  CB  LYS A  29     7451   9344   6658    117   -613    414       C  \\nATOM    228  CG  LYS A  29      55.768  60.250  -7.330  1.00 67.07           C  \\nANISOU  228  CG  LYS A  29     8072  10050   7361    167   -696    390       C  \\nATOM    229  CD  LYS A  29      55.310  61.693  -7.432  1.00 83.95           C  \\nANISOU  229  CD  LYS A  29    10248  12171   9479    234   -726    525       C  \\nATOM    230  CE  LYS A  29      53.803  61.771  -7.657  1.00 92.77           C  \\nANISOU  230  CE  LYS A  29    11299  13349  10601    297   -819    496       C  \\nATOM    231  NZ  LYS A  29      53.292  63.172  -7.546  1.00 95.08           N  \\nANISOU  231  NZ  LYS A  29    11624  13597  10903    372   -843    626       N  \\nATOM    232  N   MET A  30      60.147  58.288  -6.680  1.00 50.55           N  \\nANISOU  232  N   MET A  30     6053   7865   5290    -10   -442    300       N  \\nATOM    233  CA  MET A  30      61.554  58.076  -7.030  1.00 41.22           C  \\nANISOU  233  CA  MET A  30     4895   6708   4057    -39   -375    308       C  \\nATOM    234  C   MET A  30      62.118  56.854  -6.320  1.00 30.24           C  \\nANISOU  234  C   MET A  30     3474   5265   2751    -73   -331    209       C  \\nATOM    235  O   MET A  30      62.831  57.002  -5.333  1.00 28.86           O  \\nANISOU  235  O   MET A  30     3307   5006   2652    -97   -284    242       O  \\nATOM    236  CB  MET A  30      62.381  59.289  -6.614  1.00 42.92           C  \\nANISOU  236  CB  MET A  30     5157   6861   4289    -55   -328    436       C  \\nATOM    237  CG  MET A  30      61.814  60.615  -7.055  1.00 38.63           C  \\nANISOU  237  CG  MET A  30     4652   6325   3700    -19   -362    554       C  \\nATOM    238  SD  MET A  30      62.377  61.021  -8.712  1.00217.45           S  \\nANISOU  238  SD  MET A  30    27336  29114  26171      3   -344    631       S  \\nATOM    239  CE  MET A  30      64.133  60.809  -8.464  1.00130.57           C  \\nANISOU  239  CE  MET A  30    16336  18087  15188    -63   -239    638       C  \\nATOM    240  N   PRO A  31      61.790  55.646  -6.806  1.00 34.16           N  \\nANISOU  240  N   PRO A  31     3934   5807   3237    -71   -350     86       N  \\nATOM    241  CA  PRO A  31      62.223  54.408  -6.139  1.00 40.20           C  \\nANISOU  241  CA  PRO A  31     4672   6507   4097    -96   -309     -6       C  \\nATOM    242  C   PRO A  31      63.738  54.163  -6.150  1.00 40.22           C  \\nANISOU  242  C   PRO A  31     4688   6513   4079   -108   -235      2       C  \\nATOM    243  O   PRO A  31      64.225  53.363  -5.345  1.00 51.64           O  \\nANISOU  243  O   PRO A  31     6119   7887   5617   -120   -196    -39       O  \\nATOM    244  CB  PRO A  31      61.494  53.310  -6.934  1.00 42.24           C  \\nANISOU  244  CB  PRO A  31     4891   6821   4338    -91   -351   -143       C  \\nATOM    245  CG  PRO A  31      61.179  53.921  -8.240  1.00 34.64           C  \\nANISOU  245  CG  PRO A  31     3942   5994   3226    -60   -401   -128       C  \\nATOM    246  CD  PRO A  31      60.917  55.370  -7.962  1.00 29.36           C  \\nANISOU  246  CD  PRO A  31     3306   5311   2538    -43   -417     20       C  \\nATOM    247  N   LYS A  32      64.462  54.856  -7.026  1.00 42.97           N  \\nANISOU  247  N   LYS A  32     5064   6949   4314   -102   -214     62       N  \\nATOM    248  CA  LYS A  32      65.900  54.646  -7.208  1.00 34.90           C  \\nANISOU  248  CA  LYS A  32     4042   5955   3263   -113   -141     66       C  \\nATOM    249  C   LYS A  32      66.771  55.355  -6.167  1.00 48.78           C  \\nANISOU  249  C   LYS A  32     5807   7634   5092   -140    -96    158       C  \\nATOM    250  O   LYS A  32      67.965  55.075  -6.063  1.00 53.16           O  \\nANISOU  250  O   LYS A  32     6346   8200   5653   -151    -38    152       O  \\nATOM    251  CB  LYS A  32      66.315  55.090  -8.613  1.00 38.20           C  \\nANISOU  251  CB  LYS A  32     4481   6511   3524    -97   -126     97       C  \\nATOM    252  CG  LYS A  32      65.743  54.236  -9.734  1.00 52.65           C  \\nANISOU  252  CG  LYS A  32     6297   8445   5261    -65   -163    -21       C  \\nATOM    253  CD  LYS A  32      66.536  52.951  -9.891  1.00 50.72           C  \\nANISOU  253  CD  LYS A  32     6025   8213   5033    -61   -115   -147       C  \\nATOM    254  CE  LYS A  32      65.981  52.087 -10.993  1.00 62.81           C  \\nANISOU  254  CE  LYS A  32     7544   9844   6478    -31   -156   -287       C  \\nATOM    255  NZ  LYS A  32      65.307  50.901 -10.426  1.00 64.56           N  \\nANISOU  255  NZ  LYS A  32     7732   9967   6831    -42   -187   -420       N  \\nATOM    256  N   ILE A  33      66.175  56.267  -5.402  1.00 44.71           N  \\nANISOU  256  N   ILE A  33     5310   7047   4631   -148   -127    232       N  \\nATOM    257  CA  ILE A  33      66.924  57.072  -4.444  1.00 34.35           C  \\nANISOU  257  CA  ILE A  33     4005   5665   3382   -176    -96    308       C  \\nATOM    258  C   ILE A  33      66.526  56.782  -3.011  1.00 30.75           C  \\nANISOU  258  C   ILE A  33     3536   5108   3040   -174   -112    284       C  \\nATOM    259  O   ILE A  33      65.434  57.141  -2.591  1.00 40.82           O  \\nANISOU  259  O   ILE A  33     4822   6339   4350   -161   -155    298       O  \\nATOM    260  CB  ILE A  33      66.723  58.574  -4.688  1.00 34.96           C  \\nANISOU  260  CB  ILE A  33     4121   5733   3430   -186   -109    422       C  \\nATOM    261  CG1 ILE A  33      67.162  58.947  -6.098  1.00 38.85           C  \\nANISOU  261  CG1 ILE A  33     4631   6332   3800   -185    -83    472       C  \\nATOM    262  CG2 ILE A  33      67.505  59.389  -3.666  1.00 41.58           C  \\nANISOU  262  CG2 ILE A  33     4961   6490   4347   -223    -81    478       C  \\nATOM    263  CD1 ILE A  33      67.261  60.425  -6.305  1.00 38.46           C  \\nANISOU  263  CD1 ILE A  33     4621   6256   3736   -201    -74    605       C  \\nATOM    264  N   PRO A  34      67.423  56.138  -2.250  1.00 32.58           N  \\nANISOU  264  N   PRO A  34     3742   5311   3326   -179    -75    253       N  \\nATOM    265  CA  PRO A  34      67.173  55.915  -0.825  1.00 31.26           C  \\nANISOU  265  CA  PRO A  34     3566   5060   3251   -170    -83    246       C  \\nATOM    266  C   PRO A  34      67.280  57.263  -0.133  1.00 36.38           C  \\nANISOU  266  C   PRO A  34     4236   5667   3922   -189    -94    318       C  \\nATOM    267  O   PRO A  34      68.229  57.999  -0.436  1.00 30.61           O  \\nANISOU  267  O   PRO A  34     3507   4958   3166   -219    -71    361       O  \\nATOM    268  CB  PRO A  34      68.350  55.021  -0.385  1.00 25.17           C  \\nANISOU  268  CB  PRO A  34     2763   4292   2509   -163    -38    209       C  \\nATOM    269  CG  PRO A  34      69.117  54.687  -1.629  1.00 33.54           C  \\nANISOU  269  CG  PRO A  34     3811   5434   3498   -168     -6    183       C  \\nATOM    270  CD  PRO A  34      68.792  55.755  -2.630  1.00 29.54           C  \\nANISOU  270  CD  PRO A  34     3333   4978   2912   -189    -21    238       C  \\nATOM    271  N   ILE A  35      66.331  57.604   0.738  1.00 27.91           N  \\nANISOU  271  N   ILE A  35     3175   4533   2896   -174   -125    328       N  \\nATOM    272  CA  ILE A  35      66.413  58.882   1.442  1.00 31.14           C  \\nANISOU  272  CA  ILE A  35     3606   4894   3333   -186   -138    380       C  \\nATOM    273  C   ILE A  35      66.814  58.668   2.899  1.00 38.55           C  \\nANISOU  273  C   ILE A  35     4528   5793   4326   -176   -131    358       C  \\nATOM    274  O   ILE A  35      67.269  59.593   3.584  1.00 41.45           O  \\nANISOU  274  O   ILE A  35     4904   6130   4717   -192   -137    377       O  \\nATOM    275  CB  ILE A  35      65.095  59.688   1.337  1.00 36.91           C  \\nANISOU  275  CB  ILE A  35     4364   5592   4067   -166   -179    411       C  \\nATOM    276  CG1 ILE A  35      63.947  58.945   2.021  1.00 26.33           C  \\nANISOU  276  CG1 ILE A  35     3006   4229   2768   -131   -196    369       C  \\nATOM    277  CG2 ILE A  35      64.787  59.996  -0.117  1.00 27.26           C  \\nANISOU  277  CG2 ILE A  35     3159   4424   2775   -167   -192    445       C  \\nATOM    278  CD1 ILE A  35      62.600  59.672   1.937  1.00 22.88           C  \\nANISOU  278  CD1 ILE A  35     2582   3772   2340   -103   -237    393       C  \\nATOM    279  N   LYS A  36      66.662  57.430   3.358  1.00 39.19           N  \\nANISOU  279  N   LYS A  36     4586   5876   4427   -148   -118    317       N  \\nATOM    280  CA  LYS A  36      67.001  57.070   4.725  1.00 42.78           C  \\nANISOU  280  CA  LYS A  36     5027   6308   4919   -124   -109    306       C  \\nATOM    281  C   LYS A  36      67.115  55.550   4.806  1.00 28.88           C  \\nANISOU  281  C   LYS A  36     3242   4554   3176    -97    -80    274       C  \\nATOM    282  O   LYS A  36      66.250  54.816   4.327  1.00 35.54           O  \\nANISOU  282  O   LYS A  36     4084   5385   4034    -90    -77    251       O  \\nATOM    283  CB  LYS A  36      65.944  57.620   5.698  1.00 37.61           C  \\nANISOU  283  CB  LYS A  36     4390   5609   4290   -100   -131    317       C  \\nATOM    284  CG  LYS A  36      66.184  57.345   7.175  1.00 44.76           C  \\nANISOU  284  CG  LYS A  36     5287   6506   5214    -65   -122    311       C  \\nATOM    285  CD  LYS A  36      65.162  58.093   8.056  1.00 35.43           C  \\nANISOU  285  CD  LYS A  36     4124   5291   4045    -40   -140    318       C  \\nATOM    286  CE  LYS A  36      65.096  57.528   9.467  1.00 35.60           C  \\nANISOU  286  CE  LYS A  36     4138   5320   4070      9   -122    316       C  \\nATOM    287  NZ  LYS A  36      66.401  57.594  10.191  1.00 34.00           N  \\nANISOU  287  NZ  LYS A  36     3924   5151   3844     17   -128    304       N  \\nATOM    288  N   ARG A  37      68.199  55.085   5.404  1.00 26.89           N  \\nANISOU  288  N   ARG A  37     2968   4318   2931    -80    -61    268       N  \\nATOM    289  CA  ARG A  37      68.443  53.661   5.548  1.00 40.87           C  \\nANISOU  289  CA  ARG A  37     4718   6081   4729    -44    -29    247       C  \\nATOM    290  C   ARG A  37      69.084  53.360   6.889  1.00 32.47           C  \\nANISOU  290  C   ARG A  37     3640   5019   3679      0    -22    265       C  \\nATOM    291  O   ARG A  37      69.756  54.210   7.467  1.00 37.40           O  \\nANISOU  291  O   ARG A  37     4256   5673   4281     -6    -43    275       O  \\nATOM    292  CB  ARG A  37      69.360  53.166   4.431  1.00 36.01           C  \\nANISOU  292  CB  ARG A  37     4082   5509   4092    -56     -6    215       C  \\nATOM    293  CG  ARG A  37      68.718  53.145   3.071  1.00 31.94           C  \\nANISOU  293  CG  ARG A  37     3579   5007   3549    -83    -11    187       C  \\nATOM    294  CD  ARG A  37      69.519  52.283   2.129  1.00 37.03           C  \\nANISOU  294  CD  ARG A  37     4202   5692   4176    -76     22    139       C  \\nATOM    295  NE  ARG A  37      70.803  52.886   1.784  1.00 37.02           N  \\nANISOU  295  NE  ARG A  37     4179   5755   4133    -93     39    155       N  \\nATOM    296  CZ  ARG A  37      71.559  52.481   0.771  1.00 30.89           C  \\nANISOU  296  CZ  ARG A  37     3380   5037   3318    -93     71    120       C  \\nATOM    297  NH1 ARG A  37      71.146  51.481   0.008  1.00 33.49           N  \\nANISOU  297  NH1 ARG A  37     3714   5365   3644    -73     83     56       N  \\nATOM    298  NH2 ARG A  37      72.714  53.075   0.516  1.00 24.05           N  \\nANISOU  298  NH2 ARG A  37     2484   4232   2421   -114     94    142       N  \\nATOM    299  N   GLY A  38      68.871  52.143   7.376  1.00 28.10           N  \\nANISOU  299  N   GLY A  38     3081   4431   3162     46      7    270       N  \\nATOM    300  CA  GLY A  38      69.469  51.714   8.621  1.00 32.43           C  \\nANISOU  300  CA  GLY A  38     3618   4990   3714    104     16    301       C  \\nATOM    301  C   GLY A  38      68.867  50.433   9.158  1.00 42.28           C  \\nANISOU  301  C   GLY A  38     4873   6178   5014    151     56    328       C  \\nATOM    302  O   GLY A  38      68.281  49.646   8.412  1.00 30.78           O  \\nANISOU  302  O   GLY A  38     3419   4668   3606    135     81    304       O  \\nATOM    303  N   CYS A  39      69.013  50.232  10.466  1.00 41.02           N  \\nANISOU  303  N   CYS A  39     4716   6027   4844    210     63    377       N  \\nATOM    304  CA  CYS A  39      68.444  49.071  11.144  1.00 36.06           C  \\nANISOU  304  CA  CYS A  39     4098   5339   4265    260    112    428       C  \\nATOM    305  C   CYS A  39      67.148  49.462  11.821  1.00 32.52           C  \\nANISOU  305  C   CYS A  39     3671   4870   3817    252    121    460       C  \\nATOM    306  O   CYS A  39      66.951  50.633  12.137  1.00 32.25           O  \\nANISOU  306  O   CYS A  39     3643   4881   3729    236     83    449       O  \\nATOM    307  CB  CYS A  39      69.411  48.540  12.198  1.00 30.61           C  \\nANISOU  307  CB  CYS A  39     3397   4683   3550    345    121    479       C  \\nATOM    308  SG  CYS A  39      71.003  48.047  11.540  1.00 33.55           S  \\nANISOU  308  SG  CYS A  39     3730   5091   3926    371    113    444       S  \\nATOM    309  N   THR A  40      66.273  48.478  12.035  1.00 34.42           N  \\nANISOU  309  N   THR A  40     3916   5037   4125    263    174    497       N  \\nATOM    310  CA  THR A  40      65.006  48.690  12.727  1.00 32.22           C  \\nANISOU  310  CA  THR A  40     3645   4740   3856    260    198    535       C  \\nATOM    311  C   THR A  40      64.549  47.373  13.354  1.00 46.79           C  \\nANISOU  311  C   THR A  40     5493   6512   5774    296    274    608       C  \\nATOM    312  O   THR A  40      64.982  46.302  12.925  1.00 42.93           O  \\nANISOU  312  O   THR A  40     5000   5960   5352    305    303    607       O  \\nATOM    313  CB  THR A  40      63.920  49.213  11.756  1.00 37.46           C  \\nANISOU  313  CB  THR A  40     4299   5381   4552    186    178    478       C  \\nATOM    314  OG1 THR A  40      62.725  49.558  12.480  1.00 39.27           O  \\nANISOU  314  OG1 THR A  40     4527   5608   4787    189    199    512       O  \\nATOM    315  CG2 THR A  40      63.598  48.165  10.714  1.00 32.27           C  \\nANISOU  315  CG2 THR A  40     3626   4650   3986    146    201    438       C  \\nATOM    316  N   ASP A  41      63.691  47.441  14.374  1.00 42.34           N  \\nANISOU  316  N   ASP A  41     4934   5952   5201    321    313    673       N  \\nATOM    317  CA  ASP A  41      63.141  46.213  14.959  1.00 43.79           C  \\nANISOU  317  CA  ASP A  41     5118   6056   5464    346    399    757       C  \\nATOM    318  C   ASP A  41      61.811  45.811  14.328  1.00 40.37           C  \\nANISOU  318  C   ASP A  41     4657   5539   5144    270    435    731       C  \\nATOM    319  O   ASP A  41      61.641  44.671  13.895  1.00 47.46           O  \\nANISOU  319  O   ASP A  41     5544   6334   6155    246    480    733       O  \\nATOM    320  CB  ASP A  41      63.065  46.273  16.494  1.00 47.55           C  \\nANISOU  320  CB  ASP A  41     5612   6589   5867    428    439    862       C  \\nATOM    321  CG  ASP A  41      62.099  47.321  17.015  1.00 77.88           C  \\nANISOU  321  CG  ASP A  41     9448  10492   9650    416    433    855       C  \\nATOM    322  OD1 ASP A  41      61.351  46.976  17.956  1.00 99.11           O  \\nANISOU  322  OD1 ASP A  41    12137  13179  12341    449    506    941       O  \\nATOM    323  OD2 ASP A  41      62.097  48.474  16.520  1.00 69.38           O  \\nANISOU  323  OD2 ASP A  41     8368   9465   8528    380    363    771       O  \\nATOM    324  N   ALA A  42      60.886  46.758  14.248  1.00 27.50           N  \\nANISOU  324  N   ALA A  42     3010   3951   3489    232    410    697       N  \\nATOM    325  CA  ALA A  42      59.651  46.556  13.506  1.00 38.00           C  \\nANISOU  325  CA  ALA A  42     4299   5224   4916    156    423    651       C  \\nATOM    326  C   ALA A  42      59.704  47.418  12.251  1.00 46.01           C  \\nANISOU  326  C   ALA A  42     5305   6276   5901    106    336    544       C  \\nATOM    327  O   ALA A  42      60.195  48.553  12.288  1.00 33.62           O  \\nANISOU  327  O   ALA A  42     3756   4784   4232    125    279    526       O  \\nATOM    328  CB  ALA A  42      58.467  46.925  14.351  1.00 27.83           C  \\nANISOU  328  CB  ALA A  42     2987   3959   3629    161    466    702       C  \\nATOM    329  N   CYS A  43      59.218  46.883  11.134  1.00 50.47           N  \\nANISOU  329  N   CYS A  43     5839   6787   6550     43    325    473       N  \\nATOM    330  CA  CYS A  43      59.256  47.634   9.881  1.00 39.70           C  \\nANISOU  330  CA  CYS A  43     4469   5470   5146      3    245    381       C  \\nATOM    331  C   CYS A  43      58.351  48.853   9.916  1.00 38.15           C  \\nANISOU  331  C   CYS A  43     4256   5334   4904     -5    205    374       C  \\nATOM    332  O   CYS A  43      57.149  48.728  10.134  1.00 43.82           O  \\nANISOU  332  O   CYS A  43     4931   6035   5684    -26    231    380       O  \\nATOM    333  CB  CYS A  43      58.887  46.767   8.675  1.00 27.88           C  \\nANISOU  333  CB  CYS A  43     2939   3917   3736    -57    236    295       C  \\nATOM    334  SG  CYS A  43      59.222  47.648   7.075  1.00 37.61           S  \\nANISOU  334  SG  CYS A  43     4177   5231   4883    -86    139    193       S  \\nATOM    335  N   PRO A  44      58.932  50.039   9.694  1.00 39.87           N  \\nANISOU  335  N   PRO A  44     4505   5619   5026     11    147    360       N  \\nATOM    336  CA  PRO A  44      58.174  51.289   9.646  1.00 44.88           C  \\nANISOU  336  CA  PRO A  44     5132   6301   5620     12    104    351       C  \\nATOM    337  C   PRO A  44      57.107  51.270   8.560  1.00 40.39           C  \\nANISOU  337  C   PRO A  44     4516   5731   5097    -34     69    294       C  \\nATOM    338  O   PRO A  44      57.262  50.634   7.522  1.00 57.57           O  \\nANISOU  338  O   PRO A  44     6681   7894   7300    -71     50    238       O  \\nATOM    339  CB  PRO A  44      59.238  52.338   9.318  1.00 35.14           C  \\nANISOU  339  CB  PRO A  44     3943   5113   4295     25     50    340       C  \\nATOM    340  CG  PRO A  44      60.507  51.730   9.774  1.00 39.03           C  \\nANISOU  340  CG  PRO A  44     4460   5599   4769     47     76    362       C  \\nATOM    341  CD  PRO A  44      60.371  50.264   9.502  1.00 35.53           C  \\nANISOU  341  CD  PRO A  44     3995   5097   4408     31    121    355       C  \\nATOM    342  N   LYS A  45      56.021  51.979   8.825  1.00 37.97           N  \\nANISOU  342  N   LYS A  45     4181   5448   4798    -24     59    301       N  \\nATOM    343  CA  LYS A  45      54.879  52.004   7.946  1.00 42.27           C  \\nANISOU  343  CA  LYS A  45     4668   6007   5388    -57     22    251       C  \\nATOM    344  C   LYS A  45      55.076  52.989   6.799  1.00 37.69           C  \\nANISOU  344  C   LYS A  45     4108   5478   4734    -56    -62    216       C  \\nATOM    345  O   LYS A  45      55.727  54.024   6.950  1.00 25.69           O  \\nANISOU  345  O   LYS A  45     2641   3980   3141    -25    -86    245       O  \\nATOM    346  CB  LYS A  45      53.566  52.233   8.729  1.00 58.16           C  \\nANISOU  346  CB  LYS A  45     6623   8025   7449    -42     54    277       C  \\nATOM    347  CG  LYS A  45      53.477  53.264   9.877  1.00 81.35           C  \\nANISOU  347  CG  LYS A  45     9587  10990  10332     20     74    330       C  \\nATOM    348  CD  LYS A  45      54.258  53.202  11.205  1.00 84.48           C  \\nANISOU  348  CD  LYS A  45    10034  11380  10686     64    133    390       C  \\nATOM    349  CE  LYS A  45      55.712  53.700  11.189  1.00 51.05           C  \\nANISOU  349  CE  LYS A  45     5874   7156   6365     83     97    391       C  \\nATOM    350  NZ  LYS A  45      55.958  54.904  12.019  1.00 40.67           N  \\nANISOU  350  NZ  LYS A  45     4598   5876   4979    136     84    404       N  \\nATOM    351  N   SER A  46      54.533  52.650   5.637  1.00 32.32           N  \\nANISOU  351  N   SER A  46     3387   4819   4075    -90   -107    153       N  \\nATOM    352  CA  SER A  46      54.625  53.544   4.496  1.00 33.06           C  \\nANISOU  352  CA  SER A  46     3499   4974   4090    -82   -184    133       C  \\nATOM    353  C   SER A  46      53.680  54.714   4.690  1.00 36.55           C  \\nANISOU  353  C   SER A  46     3922   5446   4518    -42   -219    162       C  \\nATOM    354  O   SER A  46      52.792  54.670   5.539  1.00 50.46           O  \\nANISOU  354  O   SER A  46     5640   7193   6340    -29   -186    177       O  \\nATOM    355  CB  SER A  46      54.291  52.800   3.206  1.00 29.10           C  \\nANISOU  355  CB  SER A  46     2955   4502   3599   -121   -228     49       C  \\nATOM    356  OG  SER A  46      55.353  51.929   2.845  1.00 46.28           O  \\nANISOU  356  OG  SER A  46     5162   6654   5767   -146   -204     16       O  \\nATOM    357  N   SER A  47      53.884  55.772   3.914  1.00 28.97           N  \\nANISOU  357  N   SER A  47     2998   4527   3482    -17   -279    177       N  \\nATOM    358  CA  SER A  47      52.941  56.883   3.879  1.00 27.13           C  \\nANISOU  358  CA  SER A  47     2747   4321   3240     30   -321    202       C  \\nATOM    359  C   SER A  47      52.541  57.139   2.435  1.00 33.34           C  \\nANISOU  359  C   SER A  47     3514   5176   3977     34   -401    176       C  \\nATOM    360  O   SER A  47      52.971  56.431   1.522  1.00 35.36           O  \\nANISOU  360  O   SER A  47     3771   5464   4201     -1   -419    131       O  \\nATOM    361  CB  SER A  47      53.568  58.140   4.464  1.00 26.56           C  \\nANISOU  361  CB  SER A  47     2746   4219   3126     70   -315    262       C  \\nATOM    362  OG  SER A  47      54.483  58.713   3.544  1.00 32.86           O  \\nANISOU  362  OG  SER A  47     3603   5031   3849     64   -349    284       O  \\nATOM    363  N   LEU A  48      51.716  58.152   2.223  1.00 31.11           N  \\nANISOU  363  N   LEU A  48     3216   4924   3681     87   -449    205       N  \\nATOM    364  CA  LEU A  48      51.325  58.539   0.870  1.00 38.00           C  \\nANISOU  364  CA  LEU A  48     4075   5874   4488    110   -531    198       C  \\nATOM    365  C   LEU A  48      52.509  58.975  -0.004  1.00 31.89           C  \\nANISOU  365  C   LEU A  48     3387   5118   3613    106   -546    236       C  \\nATOM    366  O   LEU A  48      52.432  58.894  -1.224  1.00 44.49           O  \\nANISOU  366  O   LEU A  48     4976   6793   5137    111   -601    218       O  \\nATOM    367  CB  LEU A  48      50.301  59.673   0.910  1.00 39.91           C  \\nANISOU  367  CB  LEU A  48     4293   6134   4735    185   -576    241       C  \\nATOM    368  CG  LEU A  48      48.830  59.363   1.138  1.00 58.10           C  \\nANISOU  368  CG  LEU A  48     6484   8477   7116    203   -598    196       C  \\nATOM    369  CD1 LEU A  48      48.025  60.029   0.045  1.00 68.02           C  \\nANISOU  369  CD1 LEU A  48     7704   9820   8320    264   -694    205       C  \\nATOM    370  CD2 LEU A  48      48.580  57.867   1.169  1.00 77.36           C  \\nANISOU  370  CD2 LEU A  48     8849  10926   9619    127   -573    109       C  \\nATOM    371  N   LEU A  49      53.585  59.451   0.623  1.00 30.96           N  \\nANISOU  371  N   LEU A  49     3343   4934   3486     99   -496    287       N  \\nATOM    372  CA  LEU A  49      54.746  59.985  -0.100  1.00 32.69           C  \\nANISOU  372  CA  LEU A  49     3636   5163   3622     90   -497    335       C  \\nATOM    373  C   LEU A  49      55.982  59.079  -0.006  1.00 35.25           C  \\nANISOU  373  C   LEU A  49     3982   5474   3937     34   -445    302       C  \\nATOM    374  O   LEU A  49      56.873  59.129  -0.855  1.00 36.08           O  \\nANISOU  374  O   LEU A  49     4124   5615   3969     17   -444    317       O  \\nATOM    375  CB  LEU A  49      55.108  61.367   0.443  1.00 24.80           C  \\nANISOU  375  CB  LEU A  49     2698   4095   2628    122   -485    416       C  \\nATOM    376  CG  LEU A  49      54.139  62.490   0.096  1.00 40.75           C  \\nANISOU  376  CG  LEU A  49     4718   6122   4642    191   -538    469       C  \\nATOM    377  CD1 LEU A  49      54.562  63.793   0.768  1.00 31.46           C  \\nANISOU  377  CD1 LEU A  49     3606   4851   3496    216   -517    534       C  \\nATOM    378  CD2 LEU A  49      54.085  62.640  -1.422  1.00 33.57           C  \\nANISOU  378  CD2 LEU A  49     3818   5301   3638    209   -592    499       C  \\nATOM    379  N   VAL A  50      56.025  58.251   1.033  1.00 33.01           N  \\nANISOU  379  N   VAL A  50     3674   5142   3726     11   -397    264       N  \\nATOM    380  CA  VAL A  50      57.193  57.431   1.312  1.00 30.57           C  \\nANISOU  380  CA  VAL A  50     3384   4810   3419    -28   -346    243       C  \\nATOM    381  C   VAL A  50      56.916  55.924   1.281  1.00 27.73           C  \\nANISOU  381  C   VAL A  50     2974   4451   3111    -59   -326    165       C  \\nATOM    382  O   VAL A  50      55.974  55.433   1.891  1.00 44.21           O  \\nANISOU  382  O   VAL A  50     5011   6513   5274    -59   -316    142       O  \\nATOM    383  CB  VAL A  50      57.834  57.842   2.662  1.00 35.33           C  \\nANISOU  383  CB  VAL A  50     4020   5348   4056    -22   -299    282       C  \\nATOM    384  CG1 VAL A  50      58.902  56.851   3.081  1.00 33.73           C  \\nANISOU  384  CG1 VAL A  50     3823   5128   3867    -50   -249    259       C  \\nATOM    385  CG2 VAL A  50      58.421  59.247   2.549  1.00 30.60           C  \\nANISOU  385  CG2 VAL A  50     3476   4736   3415    -10   -314    343       C  \\nATOM    386  N   LYS A  51      57.745  55.200   0.541  1.00 20.99           N  \\nANISOU  386  N   LYS A  51     2131   3623   2222    -84   -316    125       N  \\nATOM    387  CA  LYS A  51      57.723  53.745   0.562  1.00 30.80           C  \\nANISOU  387  CA  LYS A  51     3337   4841   3525   -113   -288     49       C  \\nATOM    388  C   LYS A  51      58.820  53.234   1.501  1.00 31.26           C  \\nANISOU  388  C   LYS A  51     3422   4838   3617   -117   -221     71       C  \\nATOM    389  O   LYS A  51      59.939  53.777   1.519  1.00 35.08           O  \\nANISOU  389  O   LYS A  51     3949   5334   4046   -110   -208    112       O  \\nATOM    390  CB  LYS A  51      57.901  53.187  -0.865  1.00 28.20           C  \\nANISOU  390  CB  LYS A  51     2998   4580   3136   -128   -321    -29       C  \\nATOM    391  CG  LYS A  51      58.097  51.682  -0.942  1.00 54.20           C  \\nANISOU  391  CG  LYS A  51     6263   7834   6496   -158   -288   -120       C  \\nATOM    392  CD  LYS A  51      56.918  50.950  -0.352  1.00 73.95           C  \\nANISOU  392  CD  LYS A  51     8703  10278   9118   -181   -282   -159       C  \\nATOM    393  CE  LYS A  51      55.636  51.330  -1.063  1.00 90.55           C  \\nANISOU  393  CE  LYS A  51    10752  12449  11205   -182   -356   -198       C  \\nATOM    394  NZ  LYS A  51      54.459  50.694  -0.412  1.00 94.04           N  \\nANISOU  394  NZ  LYS A  51    11120  12836  11776   -210   -343   -230       N  \\nATOM    395  N   VAL A  52      58.503  52.203   2.287  1.00 40.94           N  \\nANISOU  395  N   VAL A  52     4619   6002   4937   -127   -178     51       N  \\nATOM    396  CA  VAL A  52      59.501  51.556   3.148  1.00 33.26           C  \\nANISOU  396  CA  VAL A  52     3667   4975   3994   -119   -117     75       C  \\nATOM    397  C   VAL A  52      59.680  50.066   2.834  1.00 36.48           C  \\nANISOU  397  C   VAL A  52     4054   5339   4470   -139    -85      8       C  \\nATOM    398  O   VAL A  52      58.750  49.289   3.026  1.00 46.16           O  \\nANISOU  398  O   VAL A  52     5237   6515   5785   -161    -70    -23       O  \\nATOM    399  CB  VAL A  52      59.134  51.694   4.639  1.00 36.26           C  \\nANISOU  399  CB  VAL A  52     4045   5308   4424    -97    -78    140       C  \\nATOM    400  CG1 VAL A  52      60.336  51.312   5.522  1.00 26.64           C  \\nANISOU  400  CG1 VAL A  52     2857   4062   3203    -72    -30    179       C  \\nATOM    401  CG2 VAL A  52      58.656  53.113   4.944  1.00 19.87           C  \\nANISOU  401  CG2 VAL A  52     1983   3264   2304    -76   -112    184       C  \\nATOM    402  N   VAL A  53      60.866  49.684   2.343  1.00 44.97           N  \\nANISOU  402  N   VAL A  53     5152   6426   5507   -133    -71    -17       N  \\nATOM    403  CA  VAL A  53      61.270  48.271   2.213  1.00 29.52           C  \\nANISOU  403  CA  VAL A  53     3184   4411   3622   -137    -29    -75       C  \\nATOM    404  C   VAL A  53      61.904  47.780   3.506  1.00 28.61           C  \\nANISOU  404  C   VAL A  53     3084   4228   3560   -104     32     -6       C  \\nATOM    405  O   VAL A  53      62.669  48.497   4.144  1.00 46.84           O  \\nANISOU  405  O   VAL A  53     5418   6566   5812    -75     36     62       O  \\nATOM    406  CB  VAL A  53      62.288  48.020   1.030  1.00 84.88           C  \\nANISOU  406  CB  VAL A  53    10209  11476  10565   -133    -38   -143       C  \\nATOM    407  CG1 VAL A  53      63.722  47.562   1.518  1.00 19.80           C  \\nANISOU  407  CG1 VAL A  53     1986   3209   2326    -96     14   -115       C  \\nATOM    408  CG2 VAL A  53      61.717  47.008   0.055  1.00 84.82           C  \\nANISOU  408  CG2 VAL A  53    10172  11454  10603   -160    -51   -264       C  \\nATOM    409  N   CYS A  54      61.572  46.560   3.899  1.00 43.68           N  \\nANISOU  409  N   CYS A  54     4975   6044   5580   -109     78    -22       N  \\nATOM    410  CA  CYS A  54      62.262  45.901   5.000  1.00 31.22           C  \\nANISOU  410  CA  CYS A  54     3412   4400   4048    -65    139     47       C  \\nATOM    411  C   CYS A  54      62.708  44.500   4.578  1.00 28.54           C  \\nANISOU  411  C   CYS A  54     3069   3980   3796    -60    178    -14       C  \\nATOM    412  O   CYS A  54      61.997  43.795   3.872  1.00 43.76           O  \\nANISOU  412  O   CYS A  54     4970   5858   5797   -103    176   -101       O  \\nATOM    413  CB  CYS A  54      61.393  45.865   6.259  1.00 31.70           C  \\nANISOU  413  CB  CYS A  54     3464   4412   4167    -60    177    131       C  \\nATOM    414  SG  CYS A  54      61.246  47.473   7.119  1.00 31.99           S  \\nANISOU  414  SG  CYS A  54     3519   4537   4100    -35    146    211       S  \\nATOM    415  N   CYS A  55      63.905  44.116   4.993  1.00 32.44           N  \\nANISOU  415  N   CYS A  55     3585   4461   4281     -5    211     23       N  \\nATOM    416  CA  CYS A  55      64.487  42.838   4.594  1.00 33.81           C  \\nANISOU  416  CA  CYS A  55     3758   4556   4534     16    250    -34       C  \\nATOM    417  C   CYS A  55      65.424  42.390   5.703  1.00 28.22           C  \\nANISOU  417  C   CYS A  55     3068   3808   3845     92    298     63       C  \\nATOM    418  O   CYS A  55      65.892  43.219   6.486  1.00 30.72           O  \\nANISOU  418  O   CYS A  55     3395   4198   4079    126    285    146       O  \\nATOM    419  CB  CYS A  55      65.239  42.992   3.266  1.00 24.54           C  \\nANISOU  419  CB  CYS A  55     2581   3458   3284     13    216   -137       C  \\nATOM    420  SG  CYS A  55      66.457  44.351   3.246  1.00 38.12           S  \\nANISOU  420  SG  CYS A  55     4314   5324   4848     42    183    -84       S  \\nATOM    421  N   ASN A  56      65.701  41.092   5.781  1.00 40.93           N  \\nANISOU  421  N   ASN A  56     4681   5306   5565    124    351     52       N  \\nATOM    422  CA  ASN A  56      66.455  40.570   6.920  1.00 42.61           C  \\nANISOU  422  CA  ASN A  56     4911   5474   5804    208    400    162       C  \\nATOM    423  C   ASN A  56      67.720  39.763   6.615  1.00 45.02           C  \\nANISOU  423  C   ASN A  56     5219   5752   6134    280    423    132       C  \\nATOM    424  O   ASN A  56      68.150  38.962   7.449  1.00 46.78           O  \\nANISOU  424  O   ASN A  56     5455   5899   6422    353    472    215       O  \\nATOM    425  CB  ASN A  56      65.541  39.772   7.854  1.00 47.63           C  \\nANISOU  425  CB  ASN A  56     5554   5982   6561    206    463    246       C  \\nATOM    426  CG  ASN A  56      64.852  38.628   7.150  1.00 67.50           C  \\nANISOU  426  CG  ASN A  56     8059   8356   9233    155    498    157       C  \\nATOM    427  OD1 ASN A  56      65.074  38.394   5.959  1.00 82.89           O  \\nANISOU  427  OD1 ASN A  56     9997  10308  11191    129    470     22       O  \\nATOM    428  ND2 ASN A  56      64.009  37.902   7.882  1.00 52.13           N  \\nANISOU  428  ND2 ASN A  56     6111   6285   7412    138    562    229       N  \\nATOM    429  N   LYS A  57      68.319  39.968   5.441  1.00 33.36           N  \\nANISOU  429  N   LYS A  57     3728   4344   4604    267    391     20       N  \\nATOM    430  CA  LYS A  57      69.663  39.443   5.210  1.00 40.25           C  \\nANISOU  430  CA  LYS A  57     4593   5227   5473    346    410     -3       C  \\nATOM    431  C   LYS A  57      70.672  40.596   5.208  1.00 47.26           C  \\nANISOU  431  C   LYS A  57     5462   6277   6216    364    368     22       C  \\nATOM    432  O   LYS A  57      70.284  41.760   5.081  1.00 37.83           O  \\nANISOU  432  O   LYS A  57     4267   5175   4933    306    323     28       O  \\nATOM    433  CB  LYS A  57      69.747  38.595   3.927  1.00 39.15           C  \\nANISOU  433  CB  LYS A  57     4447   5034   5395    333    424   -152       C  \\nATOM    434  CG  LYS A  57      69.139  39.230   2.687  1.00 64.01           C  \\nANISOU  434  CG  LYS A  57     7586   8264   8473    248    376   -269       C  \\nATOM    435  CD  LYS A  57      67.711  38.739   2.468  1.00 74.30           C  \\nANISOU  435  CD  LYS A  57     8891   9463   9877    174    375   -325       C  \\nATOM    436  CE  LYS A  57      66.818  39.800   1.836  1.00 59.33           C  \\nANISOU  436  CE  LYS A  57     6984   7672   7887     94    312   -364       C  \\nATOM    437  NZ  LYS A  57      65.409  39.654   2.306  1.00 59.93           N  \\nANISOU  437  NZ  LYS A  57     7051   7666   8054     32    312   -341       N  \\nATOM    438  N   ASP A  58      71.955  40.274   5.373  1.00 35.72           N  \\nANISOU  438  N   ASP A  58     3981   4847   4743    447    383     37       N  \\nATOM    439  CA  ASP A  58      73.019  41.283   5.443  1.00 33.51           C  \\nANISOU  439  CA  ASP A  58     3669   4716   4347    463    349     59       C  \\nATOM    440  C   ASP A  58      73.048  42.233   4.252  1.00 43.98           C  \\nANISOU  440  C   ASP A  58     4982   6149   5581    388    317    -23       C  \\nATOM    441  O   ASP A  58      73.141  41.798   3.097  1.00 33.62           O  \\nANISOU  441  O   ASP A  58     3663   4835   4275    376    332   -126       O  \\nATOM    442  CB  ASP A  58      74.395  40.616   5.562  1.00 48.98           C  \\nANISOU  442  CB  ASP A  58     5594   6692   6325    564    374     62       C  \\nATOM    443  CG  ASP A  58      74.868  40.495   7.000  1.00 54.39           C  \\nANISOU  443  CG  ASP A  58     6273   7379   7013    649    373    185       C  \\nATOM    444  OD1 ASP A  58      74.027  40.589   7.912  1.00 42.26           O  \\nANISOU  444  OD1 ASP A  58     4771   5796   5489    639    370    268       O  \\nATOM    445  OD2 ASP A  58      76.084  40.297   7.212  1.00 72.21           O  \\nANISOU  445  OD2 ASP A  58     8488   9695   9255    731    374    199       O  \\nATOM    446  N   LYS A  59      72.998  43.529   4.555  1.00 38.54           N  \\nANISOU  446  N   LYS A  59     4289   5552   4804    343    275     25       N  \\nATOM    447  CA  LYS A  59      73.133  44.589   3.558  1.00 39.02           C  \\nANISOU  447  CA  LYS A  59     4338   5716   4770    277    248    -20       C  \\nATOM    448  C   LYS A  59      72.119  44.448   2.438  1.00 42.86           C  \\nANISOU  448  C   LYS A  59     4849   6178   5259    219    243   -101       C  \\nATOM    449  O   LYS A  59      72.399  44.783   1.287  1.00 40.67           O  \\nANISOU  449  O   LYS A  59     4561   5978   4914    192    240   -165       O  \\nATOM    450  CB  LYS A  59      74.541  44.615   2.974  1.00 39.99           C  \\nANISOU  450  CB  LYS A  59     4413   5930   4851    309    266    -55       C  \\nATOM    451  CG  LYS A  59      75.648  44.980   3.955  1.00 50.56           C  \\nANISOU  451  CG  LYS A  59     5708   7329   6172    356    257     13       C  \\nATOM    452  CD  LYS A  59      76.952  45.202   3.194  1.00 55.88           C  \\nANISOU  452  CD  LYS A  59     6322   8111   6800    365    276    -29       C  \\nATOM    453  CE  LYS A  59      78.149  45.373   4.107  1.00 64.90           C  \\nANISOU  453  CE  LYS A  59     7402   9317   7940    420    265     20       C  \\nATOM    454  NZ  LYS A  59      79.386  45.625   3.296  1.00 72.10           N  \\nANISOU  454  NZ  LYS A  59     8242  10341   8814    419    291    -24       N  \\nATOM    455  N   CYS A  60      70.939  43.950   2.784  1.00 32.37           N  \\nANISOU  455  N   CYS A  60     3547   4750   4003    202    242    -98       N  \\nATOM    456  CA  CYS A  60      69.913  43.664   1.789  1.00 40.34           C  \\nANISOU  456  CA  CYS A  60     4567   5730   5029    150    231   -188       C  \\nATOM    457  C   CYS A  60      69.146  44.909   1.391  1.00 28.46           C  \\nANISOU  457  C   CYS A  60     3073   4301   3440     84    180   -175       C  \\nATOM    458  O   CYS A  60      68.394  44.881   0.428  1.00 37.85           O  \\nANISOU  458  O   CYS A  60     4265   5505   4612     45    158   -251       O  \\nATOM    459  CB  CYS A  60      68.920  42.669   2.354  1.00 31.83           C  \\nANISOU  459  CB  CYS A  60     3503   4513   4079    148    252   -188       C  \\nATOM    460  SG  CYS A  60      68.108  43.300   3.850  1.00 33.33           S  \\nANISOU  460  SG  CYS A  60     3707   4674   4284    137    243    -53       S  \\nATOM    461  N   ASN A  61      69.310  45.982   2.160  1.00 29.75           N  \\nANISOU  461  N   ASN A  61     3240   4509   3554     78    160    -83       N  \\nATOM    462  CA  ASN A  61      68.617  47.236   1.887  1.00 31.50           C  \\nANISOU  462  CA  ASN A  61     3475   4788   3707     26    114    -58       C  \\nATOM    463  C   ASN A  61      69.452  48.197   1.033  1.00 31.36           C  \\nANISOU  463  C   ASN A  61     3451   4880   3584      8    103    -60       C  \\nATOM    464  O   ASN A  61      70.395  47.762   0.376  1.00 27.49           O  \\nANISOU  464  O   ASN A  61     2942   4432   3070     28    132   -105       O  \\nATOM    465  CB  ASN A  61      68.180  47.909   3.188  1.00 35.67           C  \\nANISOU  465  CB  ASN A  61     4014   5290   4248     27    100     32       C  \\nATOM    466  CG  ASN A  61      69.350  48.465   3.987  1.00 40.90           C  \\nANISOU  466  CG  ASN A  61     4668   5997   4877     57    103     91       C  \\nATOM    467  OD1 ASN A  61      70.491  47.989   3.880  1.00 33.94           O  \\nANISOU  467  OD1 ASN A  61     3763   5139   3993     91    127     77       O  \\nATOM    468  ND2 ASN A  61      69.067  49.482   4.801  1.00 22.67           N  \\nANISOU  468  ND2 ASN A  61     2370   3703   2542     45     76    150       N  \\nATOM    469  OXT ASN A  61      69.225  49.409   0.972  1.00 22.04           O  \\nANISOU  469  OXT ASN A  61     2283   3745   2345    -26     73    -13       O  \\nTER     470      ASN A  61                                                      \\nATOM    471  N   LEU B   1      49.351  60.011  24.487  1.00 25.95           N  \\nANISOU  471  N   LEU B   1     2639   4650   2570    935    648    410       N  \\nATOM    472  CA  LEU B   1      49.863  60.966  23.507  1.00 44.64           C  \\nANISOU  472  CA  LEU B   1     5045   6930   4986    900    524    322       C  \\nATOM    473  C   LEU B   1      49.160  60.811  22.167  1.00 42.48           C  \\nANISOU  473  C   LEU B   1     4712   6576   4854    828    495    339       C  \\nATOM    474  O   LEU B   1      48.889  59.702  21.721  1.00 43.40           O  \\nANISOU  474  O   LEU B   1     4780   6675   5037    764    535    415       O  \\nATOM    475  CB  LEU B   1      51.381  60.814  23.313  1.00 25.79           C  \\nANISOU  475  CB  LEU B   1     2733   4512   2553    859    449    314       C  \\nATOM    476  CG  LEU B   1      51.969  61.760  22.249  1.00 42.34           C  \\nANISOU  476  CG  LEU B   1     4868   6514   4706    812    333    238       C  \\nATOM    477  CD1 LEU B   1      51.792  63.216  22.673  1.00 27.53           C  \\nANISOU  477  CD1 LEU B   1     3022   4637   2803    882    296    127       C  \\nATOM    478  CD2 LEU B   1      53.436  61.455  21.905  1.00 33.48           C  \\nANISOU  478  CD2 LEU B   1     3799   5363   3558    756    270    241       C  \\nATOM    479  N   LYS B   2      48.862  61.936  21.534  1.00 37.20           N  \\nANISOU  479  N   LYS B   2     4046   5857   4231    843    423    265       N  \\nATOM    480  CA  LYS B   2      48.293  61.941  20.194  1.00 41.24           C  \\nANISOU  480  CA  LYS B   2     4508   6303   4858    787    374    273       C  \\nATOM    481  C   LYS B   2      49.254  62.631  19.229  1.00 35.20           C  \\nANISOU  481  C   LYS B   2     3814   5455   4105    746    262    234       C  \\nATOM    482  O   LYS B   2      49.772  63.719  19.510  1.00 42.33           O  \\nANISOU  482  O   LYS B   2     4781   6334   4970    788    216    167       O  \\nATOM    483  CB  LYS B   2      46.940  62.661  20.177  1.00 26.62           C  \\nANISOU  483  CB  LYS B   2     2586   4470   3059    851    392    241       C  \\nATOM    484  CG  LYS B   2      45.786  61.874  20.767  1.00 42.98           C  \\nANISOU  484  CG  LYS B   2     4555   6617   5157    867    504    292       C  \\nATOM    485  CD  LYS B   2      44.452  62.360  20.210  1.00 53.56           C  \\nANISOU  485  CD  LYS B   2     5798   7961   6590    897    497    269       C  \\nATOM    486  CE  LYS B   2      43.269  61.912  21.067  1.00 65.07           C  \\nANISOU  486  CE  LYS B   2     7150   9510   8062    939    621    300       C  \\nATOM    487  NZ  LYS B   2      43.000  62.830  22.222  1.00 54.09           N  \\nANISOU  487  NZ  LYS B   2     5780   8182   6589   1060    671    245       N  \\nATOM    488  N   CYS B   3      49.487  61.998  18.090  1.00 34.08           N  \\nANISOU  488  N   CYS B   3     3658   5270   4021    663    223    271       N  \\nATOM    489  CA  CYS B   3      50.347  62.568  17.054  1.00 35.30           C  \\nANISOU  489  CA  CYS B   3     3871   5353   4187    620    128    249       C  \\nATOM    490  C   CYS B   3      49.644  62.599  15.702  1.00 32.72           C  \\nANISOU  490  C   CYS B   3     3495   4995   3940    587     79    263       C  \\nATOM    491  O   CYS B   3      48.827  61.731  15.401  1.00 41.28           O  \\nANISOU  491  O   CYS B   3     4501   6108   5076    560    111    293       O  \\nATOM    492  CB  CYS B   3      51.625  61.738  16.921  1.00 34.40           C  \\nANISOU  492  CB  CYS B   3     3801   5231   4038    554    119    277       C  \\nATOM    493  SG  CYS B   3      52.590  61.598  18.447  1.00 29.97           S  \\nANISOU  493  SG  CYS B   3     3294   4725   3368    596    161    267       S  \\nATOM    494  N   HIS B   4      49.957  63.599  14.889  1.00 21.55           N  \\nANISOU  494  N   HIS B   4     2125   3524   2538    589      1    241       N  \\nATOM    495  CA  HIS B   4      49.589  63.555  13.477  1.00 31.79           C  \\nANISOU  495  CA  HIS B   4     3392   4802   3885    554    -58    263       C  \\nATOM    496  C   HIS B   4      50.285  62.331  12.847  1.00 35.88           C  \\nANISOU  496  C   HIS B   4     3908   5327   4397    463    -59    292       C  \\nATOM    497  O   HIS B   4      51.453  62.066  13.137  1.00 36.73           O  \\nANISOU  497  O   HIS B   4     4074   5420   4460    431    -52    295       O  \\nATOM    498  CB  HIS B   4      50.015  64.843  12.759  1.00 21.47           C  \\nANISOU  498  CB  HIS B   4     2151   3428   2579    573   -133    255       C  \\nATOM    499  CG  HIS B   4      49.299  66.078  13.226  1.00 34.19           C  \\nANISOU  499  CG  HIS B   4     3766   5012   4214    666   -138    223       C  \\nATOM    500  ND1 HIS B   4      47.935  66.245  13.106  1.00 39.14           N  \\nANISOU  500  ND1 HIS B   4     4313   5671   4887    728   -133    223       N  \\nATOM    501  CD2 HIS B   4      49.767  67.218  13.787  1.00 30.02           C  \\nANISOU  501  CD2 HIS B   4     3307   4422   3676    711   -149    182       C  \\nATOM    502  CE1 HIS B   4      47.591  67.428  13.589  1.00 38.87           C  \\nANISOU  502  CE1 HIS B   4     4303   5597   4870    815   -138    188       C  \\nATOM    503  NE2 HIS B   4      48.684  68.039  14.006  1.00 36.95           N  \\nANISOU  503  NE2 HIS B   4     4153   5290   4595    804   -147    159       N  \\nATOM    504  N   ASN B   5      49.580  61.573  12.008  1.00 28.80           N  \\nANISOU  504  N   ASN B   5     2941   4454   3547    426    -69    305       N  \\nATOM    505  CA  ASN B   5      50.173  60.351  11.445  1.00 35.62           C  \\nANISOU  505  CA  ASN B   5     3800   5319   4415    345    -64    318       C  \\nATOM    506  C   ASN B   5      50.060  60.185   9.921  1.00 34.36           C  \\nANISOU  506  C   ASN B   5     3620   5163   4271    303   -135    311       C  \\nATOM    507  O   ASN B   5      50.280  59.097   9.398  1.00 36.56           O  \\nANISOU  507  O   ASN B   5     3875   5447   4567    241   -130    305       O  \\nATOM    508  CB  ASN B   5      49.626  59.105  12.159  1.00 25.59           C  \\nANISOU  508  CB  ASN B   5     2463   4073   3187    322     19    333       C  \\nATOM    509  CG  ASN B   5      48.147  58.880  11.889  1.00 38.87           C  \\nANISOU  509  CG  ASN B   5     4035   5789   4944    327     27    323       C  \\nATOM    510  OD1 ASN B   5      47.368  59.835  11.779  1.00 33.69           O  \\nANISOU  510  OD1 ASN B   5     3350   5152   4297    385     -5    308       O  \\nATOM    511  ND2 ASN B   5      47.753  57.614  11.777  1.00 32.38           N  \\nANISOU  511  ND2 ASN B   5     3145   4972   4186    265     70    328       N  \\nATOM    512  N   LYS B   6      49.707  61.262   9.229  1.00 34.59           N  \\nANISOU  512  N   LYS B   6     3659   5191   4294    344   -200    311       N  \\nATOM    513  CA  LYS B   6      49.613  61.281   7.769  1.00 40.60           C  \\nANISOU  513  CA  LYS B   6     4409   5972   5046    322   -275    311       C  \\nATOM    514  C   LYS B   6      50.307  62.539   7.282  1.00 31.70           C  \\nANISOU  514  C   LYS B   6     3368   4806   3872    352   -324    340       C  \\nATOM    515  O   LYS B   6      50.632  63.414   8.087  1.00 40.87           O  \\nANISOU  515  O   LYS B   6     4581   5920   5029    390   -305    346       O  \\nATOM    516  CB  LYS B   6      48.151  61.334   7.319  1.00 46.53           C  \\nANISOU  516  CB  LYS B   6     5061   6775   5845    357   -308    296       C  \\nATOM    517  CG  LYS B   6      47.237  60.308   7.966  1.00 44.19           C  \\nANISOU  517  CG  LYS B   6     4662   6509   5618    334   -248    271       C  \\nATOM    518  CD  LYS B   6      47.489  58.915   7.417  1.00 33.89           C  \\nANISOU  518  CD  LYS B   6     3326   5215   4337    244   -240    244       C  \\nATOM    519  CE  LYS B   6      46.531  57.918   8.060  1.00 57.71           C  \\nANISOU  519  CE  LYS B   6     6237   8248   7445    213   -173    227       C  \\nATOM    520  NZ  LYS B   6      46.663  56.563   7.459  1.00 70.91           N  \\nANISOU  520  NZ  LYS B   6     7870   9912   9162    123   -169    189       N  \\nATOM    521  N   LEU B   7      50.532  62.660   5.978  1.00 31.38           N  \\nANISOU  521  N   LEU B   7     3343   4784   3796    335   -385    358       N  \\nATOM    522  CA  LEU B   7      51.132  63.904   5.476  1.00 42.33           C  \\nANISOU  522  CA  LEU B   7     4810   6126   5147    363   -422    403       C  \\nATOM    523  C   LEU B   7      50.102  64.957   5.024  1.00 31.59           C  \\nANISOU  523  C   LEU B   7     3431   4767   3803    447   -475    433       C  \\nATOM    524  O   LEU B   7      50.449  66.053   4.582  1.00 39.07           O  \\nANISOU  524  O   LEU B   7     4444   5666   4734    480   -504    483       O  \\nATOM    525  CB  LEU B   7      52.230  63.659   4.435  1.00 48.84           C  \\nANISOU  525  CB  LEU B   7     5684   6961   5910    305   -443    426       C  \\nATOM    526  CG  LEU B   7      52.078  62.651   3.310  1.00 49.23           C  \\nANISOU  526  CG  LEU B   7     5690   7090   5927    265   -474    405       C  \\nATOM    527  CD1 LEU B   7      52.289  61.236   3.825  1.00 72.12           C  \\nANISOU  527  CD1 LEU B   7     8549  10000   8852    205   -425    350       C  \\nATOM    528  CD2 LEU B   7      50.720  62.808   2.682  1.00 31.44           C  \\nANISOU  528  CD2 LEU B   7     3366   4896   3683    318   -533    401       C  \\nATOM    529  N   VAL B   8      48.827  64.612   5.155  1.00 24.87           N  \\nANISOU  529  N   VAL B   8     2486   3970   2993    483   -483    405       N  \\nATOM    530  CA  VAL B   8      47.778  65.609   5.053  1.00 40.89           C  \\nANISOU  530  CA  VAL B   8     4484   5999   5052    580   -521    425       C  \\nATOM    531  C   VAL B   8      47.588  66.185   6.467  1.00 42.77           C  \\nANISOU  531  C   VAL B   8     4734   6178   5337    628   -463    403       C  \\nATOM    532  O   VAL B   8      48.075  65.599   7.434  1.00 32.51           O  \\nANISOU  532  O   VAL B   8     3445   4867   4040    584   -398    371       O  \\nATOM    533  CB  VAL B   8      46.473  64.987   4.494  1.00 46.21           C  \\nANISOU  533  CB  VAL B   8     5034   6773   5749    598   -563    398       C  \\nATOM    534  CG1 VAL B   8      46.711  64.391   3.104  1.00 36.97           C  \\nANISOU  534  CG1 VAL B   8     3856   5672   4518    552   -626    401       C  \\nATOM    535  CG2 VAL B   8      45.924  63.937   5.447  1.00 45.60           C  \\nANISOU  535  CG2 VAL B   8     4870   6725   5730    559   -497    340       C  \\nATOM    536  N   PRO B   9      46.908  67.339   6.599  1.00 35.33           N  \\nANISOU  536  N   PRO B   9     3794   5201   4428    726   -484    420       N  \\nATOM    537  CA  PRO B   9      46.730  67.906   7.948  1.00 38.56           C  \\nANISOU  537  CA  PRO B   9     4216   5560   4877    779   -427    383       C  \\nATOM    538  C   PRO B   9      45.725  67.139   8.836  1.00 43.61           C  \\nANISOU  538  C   PRO B   9     4747   6272   5550    793   -371    335       C  \\nATOM    539  O   PRO B   9      45.091  66.197   8.365  1.00 35.25           O  \\nANISOU  539  O   PRO B   9     3596   5294   4504    759   -381    329       O  \\nATOM    540  CB  PRO B   9      46.190  69.324   7.670  1.00 38.79           C  \\nANISOU  540  CB  PRO B   9     4270   5528   4941    888   -470    413       C  \\nATOM    541  CG  PRO B   9      46.454  69.591   6.207  1.00 36.45           C  \\nANISOU  541  CG  PRO B   9     4007   5232   4609    880   -544    486       C  \\nATOM    542  CD  PRO B   9      46.426  68.249   5.541  1.00 31.23           C  \\nANISOU  542  CD  PRO B   9     3282   4678   3906    799   -559    476       C  \\nATOM    543  N   PHE B  10      45.616  67.549  10.103  1.00 35.24           N  \\nANISOU  543  N   PHE B  10     3698   5184   4505    841   -310    297       N  \\nATOM    544  CA  PHE B  10      44.510  67.177  11.023  1.00 42.36           C  \\nANISOU  544  CA  PHE B  10     4499   6152   5443    887   -247    261       C  \\nATOM    545  C   PHE B  10      44.433  65.739  11.570  1.00 43.46           C  \\nANISOU  545  C   PHE B  10     4573   6361   5578    810   -176    252       C  \\nATOM    546  O   PHE B  10      44.309  65.539  12.782  1.00 46.87           O  \\nANISOU  546  O   PHE B  10     4992   6813   6003    829    -95    229       O  \\nATOM    547  CB  PHE B  10      43.151  67.557  10.432  1.00 47.01           C  \\nANISOU  547  CB  PHE B  10     4988   6789   6087    967   -290    268       C  \\nATOM    548  CG  PHE B  10      42.002  67.337  11.373  1.00 45.93           C  \\nANISOU  548  CG  PHE B  10     4740   6718   5993   1022   -220    232       C  \\nATOM    549  CD1 PHE B  10      41.794  68.197  12.442  1.00 52.33           C  \\nANISOU  549  CD1 PHE B  10     5575   7498   6809   1115   -170    196       C  \\nATOM    550  CD2 PHE B  10      41.132  66.268  11.191  1.00 49.66           C  \\nANISOU  550  CD2 PHE B  10     5080   7286   6505    979   -200    229       C  \\nATOM    551  CE1 PHE B  10      40.742  67.996  13.317  1.00 53.96           C  \\nANISOU  551  CE1 PHE B  10     5677   7779   7048   1170    -95    165       C  \\nATOM    552  CE2 PHE B  10      40.067  66.060  12.063  1.00 52.27           C  \\nANISOU  552  CE2 PHE B  10     5298   7681   6881   1024   -124    203       C  \\nATOM    553  CZ  PHE B  10      39.872  66.926  13.124  1.00 54.36           C  \\nANISOU  553  CZ  PHE B  10     5588   7926   7139   1123    -68    175       C  \\nATOM    554  N   LEU B  11      44.448  64.755  10.674  1.00 37.59           N  \\nANISOU  554  N   LEU B  11     3786   5655   4842    729   -205    269       N  \\nATOM    555  CA  LEU B  11      44.377  63.346  11.057  1.00 39.03           C  \\nANISOU  555  CA  LEU B  11     3908   5882   5041    649   -140    265       C  \\nATOM    556  C   LEU B  11      45.374  62.988  12.160  1.00 45.36           C  \\nANISOU  556  C   LEU B  11     4785   6654   5794    620    -66    269       C  \\nATOM    557  O   LEU B  11      46.527  63.435  12.154  1.00 43.70           O  \\nANISOU  557  O   LEU B  11     4682   6390   5531    609    -90    272       O  \\nATOM    558  CB  LEU B  11      44.622  62.459   9.830  1.00 33.74           C  \\nANISOU  558  CB  LEU B  11     3216   5227   4375    561   -195    269       C  \\nATOM    559  CG  LEU B  11      43.399  61.860   9.122  1.00 50.01           C  \\nANISOU  559  CG  LEU B  11     5139   7359   6502    544   -225    247       C  \\nATOM    560  CD1 LEU B  11      42.155  62.678   9.410  1.00 38.31           C  \\nANISOU  560  CD1 LEU B  11     3574   5918   5064    643   -228    239       C  \\nATOM    561  CD2 LEU B  11      43.633  61.731   7.615  1.00 43.45           C  \\nANISOU  561  CD2 LEU B  11     4316   6548   5646    509   -326    242       C  \\nATOM    562  N   SER B  12      44.933  62.176  13.109  1.00 36.13           N  \\nANISOU  562  N   SER B  12     3558   5526   4645    609     26    273       N  \\nATOM    563  CA  SER B  12      45.831  61.750  14.169  1.00 32.40           C  \\nANISOU  563  CA  SER B  12     3151   5043   4116    592     95    287       C  \\nATOM    564  C   SER B  12      45.447  60.393  14.723  1.00 35.10           C  \\nANISOU  564  C   SER B  12     3422   5422   4493    541    188    319       C  \\nATOM    565  O   SER B  12      44.368  59.862  14.437  1.00 32.94           O  \\nANISOU  565  O   SER B  12     3036   5182   4298    519    209    321       O  \\nATOM    566  CB  SER B  12      45.850  62.779  15.306  1.00 29.68           C  \\nANISOU  566  CB  SER B  12     2853   4702   3722    686    129    261       C  \\nATOM    567  OG  SER B  12      44.574  62.855  15.927  1.00 36.50           O  \\nANISOU  567  OG  SER B  12     3621   5624   4623    747    192    253       O  \\nATOM    568  N   LYS B  13      46.349  59.844  15.526  1.00 25.92           N  \\nANISOU  568  N   LYS B  13     2322   4251   3275    522    243    346       N  \\nATOM    569  CA  LYS B  13      46.098  58.615  16.247  1.00 32.20           C  \\nANISOU  569  CA  LYS B  13     3068   5071   4095    487    346    396       C  \\nATOM    570  C   LYS B  13      46.627  58.796  17.647  1.00 42.99           C  \\nANISOU  570  C   LYS B  13     4498   6469   5368    548    415    417       C  \\nATOM    571  O   LYS B  13      47.476  59.662  17.903  1.00 38.02           O  \\nANISOU  571  O   LYS B  13     3958   5829   4658    591    368    383       O  \\nATOM    572  CB  LYS B  13      46.836  57.446  15.594  1.00 24.48           C  \\nANISOU  572  CB  LYS B  13     2108   4045   3147    393    335    420       C  \\nATOM    573  CG  LYS B  13      48.359  57.525  15.725  1.00 40.69           C  \\nANISOU  573  CG  LYS B  13     4278   6067   5114    390    304    426       C  \\nATOM    574  CD  LYS B  13      49.042  56.309  15.107  1.00 50.21           C  \\nANISOU  574  CD  LYS B  13     5494   7227   6355    307    302    448       C  \\nATOM    575  CE  LYS B  13      48.585  55.017  15.774  1.00 53.98           C  \\nANISOU  575  CE  LYS B  13     5916   7701   6892    277    411    508       C  \\nATOM    576  NZ  LYS B  13      49.261  53.827  15.196  1.00 64.66           N  \\nANISOU  576  NZ  LYS B  13     7283   8993   8292    204    412    524       N  \\nATOM    577  N   THR B  14      46.117  57.977  18.557  1.00 43.69           N  \\nANISOU  577  N   THR B  14     4535   6599   5466    552    528    472       N  \\nATOM    578  CA  THR B  14      46.685  57.880  19.882  1.00 24.66           C  \\nANISOU  578  CA  THR B  14     2184   4234   2952    607    600    508       C  \\nATOM    579  C   THR B  14      47.843  56.892  19.801  1.00 29.15           C  \\nANISOU  579  C   THR B  14     2814   4762   3501    550    599    558       C  \\nATOM    580  O   THR B  14      47.685  55.780  19.291  1.00 28.26           O  \\nANISOU  580  O   THR B  14     2658   4606   3476    473    627    603       O  \\nATOM    581  CB  THR B  14      45.639  57.365  20.897  1.00 44.50           C  \\nANISOU  581  CB  THR B  14     4616   6816   5477    639    735    567       C  \\nATOM    582  OG1 THR B  14      44.578  58.325  21.021  1.00 30.50           O  \\nANISOU  582  OG1 THR B  14     2780   5090   3718    705    739    514       O  \\nATOM    583  CG2 THR B  14      46.290  57.106  22.286  1.00 35.29           C  \\nANISOU  583  CG2 THR B  14     3515   5710   4182    700    815    621       C  \\nATOM    584  N   CYS B  15      49.006  57.298  20.296  1.00 23.62           N  \\nANISOU  584  N   CYS B  15     2209   4073   2693    589    564    544       N  \\nATOM    585  CA  CYS B  15      50.177  56.434  20.309  1.00 33.14           C  \\nANISOU  585  CA  CYS B  15     3471   5251   3870    553    560    590       C  \\nATOM    586  C   CYS B  15      50.013  55.204  21.203  1.00 37.59           C  \\nANISOU  586  C   CYS B  15     4014   5840   4430    559    680    696       C  \\nATOM    587  O   CYS B  15      49.482  55.283  22.315  1.00 30.37           O  \\nANISOU  587  O   CYS B  15     3083   5000   3455    625    765    732       O  \\nATOM    588  CB  CYS B  15      51.403  57.215  20.769  1.00 41.20           C  \\nANISOU  588  CB  CYS B  15     4584   6298   4774    601    497    544       C  \\nATOM    589  SG  CYS B  15      51.716  58.681  19.805  1.00 43.73           S  \\nANISOU  589  SG  CYS B  15     4940   6571   5106    592    370    436       S  \\nATOM    590  N   PRO B  16      50.504  54.065  20.718  1.00 37.18           N  \\nANISOU  590  N   PRO B  16     3965   5723   4439    493    690    748       N  \\nATOM    591  CA  PRO B  16      50.578  52.819  21.485  1.00 24.44           C  \\nANISOU  591  CA  PRO B  16     2348   4107   2831    497    799    863       C  \\nATOM    592  C   PRO B  16      51.488  52.988  22.704  1.00 40.25           C  \\nANISOU  592  C   PRO B  16     4426   6190   4676    590    816    902       C  \\nATOM    593  O   PRO B  16      52.335  53.891  22.726  1.00 24.12           O  \\nANISOU  593  O   PRO B  16     2442   4180   2541    626    726    827       O  \\nATOM    594  CB  PRO B  16      51.251  51.846  20.506  1.00 33.38           C  \\nANISOU  594  CB  PRO B  16     3492   5138   4052    417    765    873       C  \\nATOM    595  CG  PRO B  16      51.221  52.524  19.165  1.00 41.57           C  \\nANISOU  595  CG  PRO B  16     4516   6137   5140    362    652    765       C  \\nATOM    596  CD  PRO B  16      51.203  53.980  19.423  1.00 22.68           C  \\nANISOU  596  CD  PRO B  16     2151   3812   2656    424    593    697       C  \\nATOM    597  N   GLU B  17      51.314  52.126  23.704  1.00 31.77           N  \\nANISOU  597  N   GLU B  17     3348   5149   3572    628    932   1020       N  \\nATOM    598  CA  GLU B  17      52.196  52.116  24.866  1.00 46.70           C  \\nANISOU  598  CA  GLU B  17     5309   7130   5306    723    949   1071       C  \\nATOM    599  C   GLU B  17      53.632  51.994  24.396  1.00 39.44           C  \\nANISOU  599  C   GLU B  17     4452   6174   4359    713    850   1041       C  \\nATOM    600  O   GLU B  17      53.918  51.241  23.473  1.00 38.84           O  \\nANISOU  600  O   GLU B  17     4367   5995   4394    638    832   1054       O  \\nATOM    601  CB  GLU B  17      51.862  50.943  25.790  1.00 28.10           C  \\nANISOU  601  CB  GLU B  17     2941   4792   2945    754   1093   1231       C  \\nATOM    602  CG  GLU B  17      50.459  51.009  26.337  1.00 46.85           C  \\nANISOU  602  CG  GLU B  17     5244   7214   5344    765   1209   1273       C  \\nATOM    603  CD  GLU B  17      50.151  49.889  27.300  1.00 60.26           C  \\nANISOU  603  CD  GLU B  17     6933   8932   7032    797   1364   1447       C  \\nATOM    604  OE1 GLU B  17      48.957  49.580  27.457  1.00 61.25           O  \\nANISOU  604  OE1 GLU B  17     6979   9052   7242    765   1476   1502       O  \\nATOM    605  OE2 GLU B  17      51.090  49.332  27.910  1.00 57.16           O  \\nANISOU  605  OE2 GLU B  17     6608   8563   6548    856   1377   1535       O  \\nATOM    606  N   GLY B  18      54.529  52.754  25.012  1.00 38.06           N  \\nANISOU  606  N   GLY B  18     4334   6088   4039    785    785    990       N  \\nATOM    607  CA  GLY B  18      55.937  52.674  24.675  1.00 37.88           C  \\nANISOU  607  CA  GLY B  18     4360   6050   3984    781    694    962       C  \\nATOM    608  C   GLY B  18      56.393  53.774  23.737  1.00 42.08           C  \\nANISOU  608  C   GLY B  18     4902   6549   4537    733    570    823       C  \\nATOM    609  O   GLY B  18      57.556  54.144  23.749  1.00 39.68           O  \\nANISOU  609  O   GLY B  18     4636   6272   4169    748    490    774       O  \\nATOM    610  N   LYS B  19      55.480  54.300  22.926  1.00 46.31           N  \\nANISOU  610  N   LYS B  19     5401   7030   5167    675    557    766       N  \\nATOM    611  CA  LYS B  19      55.810  55.400  22.022  1.00 38.96           C  \\nANISOU  611  CA  LYS B  19     4482   6063   4257    634    449    651       C  \\nATOM    612  C   LYS B  19      55.288  56.737  22.557  1.00 34.42           C  \\nANISOU  612  C   LYS B  19     3912   5542   3622    687    428    569       C  \\nATOM    613  O   LYS B  19      54.135  57.099  22.348  1.00 44.24           O  \\nANISOU  613  O   LYS B  19     5115   6771   4921    682    456    554       O  \\nATOM    614  CB  LYS B  19      55.267  55.130  20.614  1.00 34.11           C  \\nANISOU  614  CB  LYS B  19     3827   5350   3782    542    431    639       C  \\nATOM    615  CG  LYS B  19      55.632  53.760  20.055  1.00 23.36           C  \\nANISOU  615  CG  LYS B  19     2456   3924   2496    490    460    705       C  \\nATOM    616  CD  LYS B  19      55.196  53.608  18.598  1.00 32.98           C  \\nANISOU  616  CD  LYS B  19     3637   5060   3833    402    423    665       C  \\nATOM    617  CE  LYS B  19      55.618  52.260  18.023  1.00 44.64           C  \\nANISOU  617  CE  LYS B  19     5107   6467   5388    352    448    708       C  \\nATOM    618  NZ  LYS B  19      55.379  52.163  16.545  1.00 46.57           N  \\nANISOU  618  NZ  LYS B  19     5323   6648   5725    271    396    648       N  \\nATOM    619  N   ASN B  20      56.155  57.469  23.242  1.00 40.14           N  \\nANISOU  619  N   ASN B  20     4683   6329   4238    738    375    508       N  \\nATOM    620  CA  ASN B  20      55.787  58.744  23.842  1.00 37.88           C  \\nANISOU  620  CA  ASN B  20     4410   6090   3892    795    352    414       C  \\nATOM    621  C   ASN B  20      56.423  59.953  23.140  1.00 44.96           C  \\nANISOU  621  C   ASN B  20     5336   6928   4818    757    243    301       C  \\nATOM    622  O   ASN B  20      56.601  61.011  23.753  1.00 24.87           O  \\nANISOU  622  O   ASN B  20     2819   4419   2212    804    204    206       O  \\nATOM    623  CB  ASN B  20      56.162  58.756  25.323  1.00 42.17           C  \\nANISOU  623  CB  ASN B  20     4981   6760   4281    893    380    414       C  \\nATOM    624  CG  ASN B  20      55.558  57.584  26.095  1.00 51.62           C  \\nANISOU  624  CG  ASN B  20     6154   8019   5440    939    501    546       C  \\nATOM    625  OD1 ASN B  20      54.336  57.385  26.121  1.00 44.42           O  \\nANISOU  625  OD1 ASN B  20     5198   7100   4581    941    585    589       O  \\nATOM    626  ND2 ASN B  20      56.423  56.805  26.737  1.00 49.55           N  \\nANISOU  626  ND2 ASN B  20     5918   7818   5090    978    514    615       N  \\nATOM    627  N   LEU B  21      56.776  59.785  21.865  1.00 34.96           N  \\nANISOU  627  N   LEU B  21     4066   5573   3646    672    197    311       N  \\nATOM    628  CA  LEU B  21      57.212  60.911  21.033  1.00 43.83           C  \\nANISOU  628  CA  LEU B  21     5212   6626   4815    627    109    227       C  \\nATOM    629  C   LEU B  21      56.448  60.960  19.711  1.00 40.10           C  \\nANISOU  629  C   LEU B  21     4712   6069   4455    568    100    248       C  \\nATOM    630  O   LEU B  21      56.188  59.920  19.091  1.00 43.20           O  \\nANISOU  630  O   LEU B  21     5073   6442   4899    526    132    316       O  \\nATOM    631  CB  LEU B  21      58.713  60.841  20.737  1.00 23.93           C  \\nANISOU  631  CB  LEU B  21     2718   4099   2276    582     46    209       C  \\nATOM    632  CG  LEU B  21      59.699  61.019  21.880  1.00 44.84           C  \\nANISOU  632  CG  LEU B  21     5389   6833   4815    633     20    163       C  \\nATOM    633  CD1 LEU B  21      61.092  60.717  21.366  1.00 36.09           C  \\nANISOU  633  CD1 LEU B  21     4284   5714   3713    578    -34    163       C  \\nATOM    634  CD2 LEU B  21      59.612  62.428  22.460  1.00 41.80           C  \\nANISOU  634  CD2 LEU B  21     5028   6455   4399    669    -23     45       C  \\nATOM    635  N   CYS B  22      56.092  62.169  19.283  1.00 32.48           N  \\nANISOU  635  N   CYS B  22     3759   5053   3529    570     55    186       N  \\nATOM    636  CA  CYS B  22      55.630  62.393  17.916  1.00 20.28           C  \\nANISOU  636  CA  CYS B  22     2198   3434   2075    517     23    201       C  \\nATOM    637  C   CYS B  22      56.871  62.638  17.044  1.00 36.67           C  \\nANISOU  637  C   CYS B  22     4309   5460   4164    449    -42    190       C  \\nATOM    638  O   CYS B  22      57.883  63.171  17.523  1.00 33.76           O  \\nANISOU  638  O   CYS B  22     3976   5096   3754    449    -76    142       O  \\nATOM    639  CB  CYS B  22      54.696  63.603  17.847  1.00 20.79           C  \\nANISOU  639  CB  CYS B  22     2261   3462   2176    563      6    154       C  \\nATOM    640  SG  CYS B  22      53.162  63.502  18.828  1.00 23.93           S  \\nANISOU  640  SG  CYS B  22     2604   3924   2564    650     87    157       S  \\nATOM    641  N   TYR B  23      56.810  62.234  15.781  1.00 31.06           N  \\nANISOU  641  N   TYR B  23     3582   4711   3506    391    -59    230       N  \\nATOM    642  CA  TYR B  23      57.896  62.539  14.859  1.00 37.83           C  \\nANISOU  642  CA  TYR B  23     4470   5528   4375    329   -111    225       C  \\nATOM    643  C   TYR B  23      57.350  63.094  13.556  1.00 39.21           C  \\nANISOU  643  C   TYR B  23     4643   5649   4606    303   -146    242       C  \\nATOM    644  O   TYR B  23      56.216  62.800  13.176  1.00 33.59           O  \\nANISOU  644  O   TYR B  23     3893   4944   3926    319   -133    265       O  \\nATOM    645  CB  TYR B  23      58.782  61.315  14.590  1.00 24.94           C  \\nANISOU  645  CB  TYR B  23     2826   3923   2725    285    -97    261       C  \\nATOM    646  CG  TYR B  23      58.169  60.299  13.640  1.00 35.57           C  \\nANISOU  646  CG  TYR B  23     4136   5263   4115    253    -77    305       C  \\nATOM    647  CD1 TYR B  23      57.345  59.287  14.113  1.00 35.66           C  \\nANISOU  647  CD1 TYR B  23     4108   5299   4141    274    -19    336       C  \\nATOM    648  CD2 TYR B  23      58.422  60.351  12.276  1.00 23.39           C  \\nANISOU  648  CD2 TYR B  23     2596   3692   2598    200   -113    313       C  \\nATOM    649  CE1 TYR B  23      56.785  58.358  13.253  1.00 41.81           C  \\nANISOU  649  CE1 TYR B  23     4847   6065   4974    236     -5    360       C  \\nATOM    650  CE2 TYR B  23      57.869  59.427  11.408  1.00 41.14           C  \\nANISOU  650  CE2 TYR B  23     4808   5943   4880    172   -102    333       C  \\nATOM    651  CZ  TYR B  23      57.048  58.434  11.906  1.00 47.52           C  \\nANISOU  651  CZ  TYR B  23     5574   6766   5716    187    -51    349       C  \\nATOM    652  OH  TYR B  23      56.483  57.510  11.064  1.00 48.05           O  \\nANISOU  652  OH  TYR B  23     5598   6827   5830    151    -43    354       O  \\nATOM    653  N   LYS B  24      58.167  63.907  12.890  1.00 35.17           N  \\nANISOU  653  N   LYS B  24     4168   5089   4104    264   -191    234       N  \\nATOM    654  CA  LYS B  24      57.860  64.412  11.561  1.00 34.09           C  \\nANISOU  654  CA  LYS B  24     4039   4909   4004    240   -224    267       C  \\nATOM    655  C   LYS B  24      59.108  64.347  10.707  1.00 36.59           C  \\nANISOU  655  C   LYS B  24     4378   5215   4311    170   -243    286       C  \\nATOM    656  O   LYS B  24      60.148  64.886  11.082  1.00 39.69           O  \\nANISOU  656  O   LYS B  24     4796   5586   4698    145   -253    260       O  \\nATOM    657  CB  LYS B  24      57.357  65.858  11.601  1.00 23.39           C  \\nANISOU  657  CB  LYS B  24     2715   3487   2687    280   -251    250       C  \\nATOM    658  CG  LYS B  24      57.154  66.458  10.189  1.00 35.02           C  \\nANISOU  658  CG  LYS B  24     4203   4913   4188    263   -287    303       C  \\nATOM    659  CD  LYS B  24      56.405  67.808  10.188  1.00 24.08           C  \\nANISOU  659  CD  LYS B  24     2843   3452   2852    322   -310    301       C  \\nATOM    660  CE  LYS B  24      57.235  68.914  10.834  1.00 33.48           C  \\nANISOU  660  CE  LYS B  24     4088   4562   4072    312   -318    254       C  \\nATOM    661  NZ  LYS B  24      56.538  70.244  10.801  1.00 28.39           N  \\nANISOU  661  NZ  LYS B  24     3475   3822   3490    373   -337    251       N  \\nATOM    662  N   MET B  25      59.007  63.684   9.559  1.00 30.97           N  \\nANISOU  662  N   MET B  25     3647   4525   3594    139   -247    325       N  \\nATOM    663  CA  MET B  25      60.099  63.666   8.595  1.00 23.98           C  \\nANISOU  663  CA  MET B  25     2779   3639   2693     79   -258    349       C  \\nATOM    664  C   MET B  25      59.827  64.640   7.476  1.00 24.71           C  \\nANISOU  664  C   MET B  25     2898   3692   2798     74   -289    392       C  \\nATOM    665  O   MET B  25      58.715  64.708   6.961  1.00 36.19           O  \\nANISOU  665  O   MET B  25     4339   5154   4259    109   -306    413       O  \\nATOM    666  CB  MET B  25      60.282  62.271   8.012  1.00 19.69           C  \\nANISOU  666  CB  MET B  25     2204   3153   2127     52   -240    357       C  \\nATOM    667  CG  MET B  25      60.733  61.255   9.032  1.00 38.09           C  \\nANISOU  667  CG  MET B  25     4512   5512   4446     58   -205    333       C  \\nATOM    668  SD  MET B  25      61.211  59.709   8.266  1.00 59.62           S  \\nANISOU  668  SD  MET B  25     7211   8280   7163     25   -182    337       S  \\nATOM    669  CE  MET B  25      61.530  58.717   9.720  1.00 47.97           C  \\nANISOU  669  CE  MET B  25     5719   6822   5686     56   -138    329       C  \\nATOM    670  N   THR B  26      60.848  65.399   7.102  1.00 35.52           N  \\nANISOU  670  N   THR B  26     4301   5022   4171     30   -294    411       N  \\nATOM    671  CA  THR B  26      60.772  66.274   5.932  1.00 37.31           C  \\nANISOU  671  CA  THR B  26     4560   5213   4404     20   -313    476       C  \\nATOM    672  C   THR B  26      62.011  66.048   5.075  1.00 31.07           C  \\nANISOU  672  C   THR B  26     3774   4449   3581    -48   -296    507       C  \\nATOM    673  O   THR B  26      63.033  65.560   5.569  1.00 29.70           O  \\nANISOU  673  O   THR B  26     3583   4299   3403    -87   -275    471       O  \\nATOM    674  CB  THR B  26      60.754  67.763   6.365  1.00 39.65           C  \\nANISOU  674  CB  THR B  26     4900   5404   4760     34   -325    479       C  \\nATOM    675  OG1 THR B  26      61.861  68.012   7.249  1.00 32.85           O  \\nANISOU  675  OG1 THR B  26     4044   4514   3923     -9   -312    426       O  \\nATOM    676  CG2 THR B  26      59.444  68.102   7.084  1.00 26.33           C  \\nANISOU  676  CG2 THR B  26     3209   3693   3104    115   -339    450       C  \\nATOM    677  N   LEU B  27      61.936  66.385   3.795  1.00 26.34           N  \\nANISOU  677  N   LEU B  27     3194   3858   2955    -56   -302    577       N  \\nATOM    678  CA  LEU B  27      63.158  66.530   2.996  1.00 37.00           C  \\nANISOU  678  CA  LEU B  27     4555   5221   4281   -120   -276    620       C  \\nATOM    679  C   LEU B  27      63.877  67.790   3.443  1.00 40.31           C  \\nANISOU  679  C   LEU B  27     5006   5540   4771   -158   -266    635       C  \\nATOM    680  O   LEU B  27      63.245  68.836   3.596  1.00 36.30           O  \\nANISOU  680  O   LEU B  27     4534   4946   4313   -126   -283    660       O  \\nATOM    681  CB  LEU B  27      62.837  66.660   1.515  1.00 26.87           C  \\nANISOU  681  CB  LEU B  27     3290   3981   2938   -109   -282    701       C  \\nATOM    682  CG  LEU B  27      62.205  65.449   0.831  1.00 35.98           C  \\nANISOU  682  CG  LEU B  27     4409   5241   4020    -81   -298    677       C  \\nATOM    683  CD1 LEU B  27      62.057  65.742  -0.655  1.00 27.51           C  \\nANISOU  683  CD1 LEU B  27     3359   4222   2871    -70   -307    758       C  \\nATOM    684  CD2 LEU B  27      63.045  64.200   1.056  1.00 24.99           C  \\nANISOU  684  CD2 LEU B  27     2979   3909   2608   -120   -267    612       C  \\nATOM    685  N   MET B  28      65.186  67.695   3.658  1.00 41.15           N  \\nANISOU  685  N   MET B  28     5093   5653   4888   -225   -238    613       N  \\nATOM    686  CA  MET B  28      65.964  68.837   4.147  1.00 40.10           C  \\nANISOU  686  CA  MET B  28     4976   5424   4836   -277   -230    608       C  \\nATOM    687  C   MET B  28      65.748  70.091   3.292  1.00 42.81           C  \\nANISOU  687  C   MET B  28     5373   5675   5219   -286   -222    707       C  \\nATOM    688  O   MET B  28      65.691  71.207   3.808  1.00 42.45           O  \\nANISOU  688  O   MET B  28     5357   5510   5261   -292   -230    699       O  \\nATOM    689  CB  MET B  28      67.453  68.480   4.254  1.00 39.61           C  \\nANISOU  689  CB  MET B  28     4870   5404   4776   -354   -201    579       C  \\nATOM    690  CG  MET B  28      67.780  67.628   5.476  1.00 52.21           C  \\nANISOU  690  CG  MET B  28     6421   7054   6362   -339   -216    477       C  \\nATOM    691  SD  MET B  28      69.529  67.552   5.892  1.00101.23           S  \\nANISOU  691  SD  MET B  28    12569  13295  12597   -420   -199    429       S  \\nATOM    692  CE  MET B  28      69.472  66.801   7.525  1.00 45.54           C  \\nANISOU  692  CE  MET B  28     5485   6293   5526   -365   -235    319       C  \\nATOM    693  N   LYS B  29      65.577  69.897   1.991  1.00 33.96           N  \\nANISOU  693  N   LYS B  29     4264   4608   4031   -278   -206    799       N  \\nATOM    694  CA  LYS B  29      65.377  71.016   1.079  1.00 59.92           C  \\nANISOU  694  CA  LYS B  29     7605   7822   7341   -276   -193    917       C  \\nATOM    695  C   LYS B  29      63.937  71.560   1.051  1.00 61.95           C  \\nANISOU  695  C   LYS B  29     7902   8027   7610   -182   -237    949       C  \\nATOM    696  O   LYS B  29      63.697  72.669   0.564  1.00 68.42           O  \\nANISOU  696  O   LYS B  29     8772   8751   8473   -166   -232   1043       O  \\nATOM    697  CB  LYS B  29      65.862  70.642  -0.330  1.00 69.78           C  \\nANISOU  697  CB  LYS B  29     8852   9166   8496   -300   -156   1011       C  \\nATOM    698  CG  LYS B  29      67.390  70.583  -0.443  1.00 75.56           C  \\nANISOU  698  CG  LYS B  29     9550   9914   9244   -400    -97   1012       C  \\nATOM    699  CD  LYS B  29      67.862  70.105  -1.817  1.00 85.82           C  \\nANISOU  699  CD  LYS B  29    10843  11329  10435   -414    -52   1094       C  \\nATOM    700  CE  LYS B  29      69.376  70.263  -1.966  1.00 91.49           C  \\nANISOU  700  CE  LYS B  29    11523  12053  11186   -515     17   1112       C  \\nATOM    701  NZ  LYS B  29      69.901  69.602  -3.197  1.00 92.52           N  \\nANISOU  701  NZ  LYS B  29    11635  12321  11199   -523     68   1168       N  \\nATOM    702  N   MET B  30      62.989  70.789   1.586  1.00 54.77           N  \\nANISOU  702  N   MET B  30     6965   7177   6670   -118   -276    875       N  \\nATOM    703  CA  MET B  30      61.578  71.186   1.599  1.00 39.85           C  \\nANISOU  703  CA  MET B  30     5093   5259   4791    -23   -318    893       C  \\nATOM    704  C   MET B  30      60.970  71.027   2.986  1.00 36.15           C  \\nANISOU  704  C   MET B  30     4602   4764   4372     16   -338    782       C  \\nATOM    705  O   MET B  30      60.201  70.092   3.219  1.00 35.16           O  \\nANISOU  705  O   MET B  30     4433   4722   4202     58   -357    734       O  \\nATOM    706  CB  MET B  30      60.781  70.311   0.632  1.00 49.71           C  \\nANISOU  706  CB  MET B  30     6316   6636   5935     26   -344    922       C  \\nATOM    707  CG  MET B  30      61.366  70.197  -0.771  1.00 40.48           C  \\nANISOU  707  CG  MET B  30     5163   5539   4681     -3   -323   1017       C  \\nATOM    708  SD  MET B  30      60.807  71.567  -1.791  1.00217.11           S  \\nANISOU  708  SD  MET B  30    27598  27842  27051     57   -335   1174       S  \\nATOM    709  CE  MET B  30      59.041  71.415  -1.551  1.00129.03           C  \\nANISOU  709  CE  MET B  30    16416  16718  15892    176   -409   1136       C  \\nATOM    710  N   PRO B  31      61.303  71.937   3.917  1.00 36.95           N  \\nANISOU  710  N   PRO B  31     4727   4748   4564      1   -332    739       N  \\nATOM    711  CA  PRO B  31      60.835  71.809   5.306  1.00 39.89           C  \\nANISOU  711  CA  PRO B  31     5079   5108   4969     40   -346    627       C  \\nATOM    712  C   PRO B  31      59.316  71.926   5.475  1.00 41.51           C  \\nANISOU  712  C   PRO B  31     5278   5315   5178    145   -374    623       C  \\nATOM    713  O   PRO B  31      58.790  71.506   6.511  1.00 53.11           O  \\nANISOU  713  O   PRO B  31     6717   6816   6647    184   -377    539       O  \\nATOM    714  CB  PRO B  31      61.549  72.964   6.035  1.00 34.21           C  \\nANISOU  714  CB  PRO B  31     4395   4255   4347      1   -338    584       C  \\nATOM    715  CG  PRO B  31      61.894  73.947   4.952  1.00 36.18           C  \\nANISOU  715  CG  PRO B  31     4693   4410   4643    -31   -323    699       C  \\nATOM    716  CD  PRO B  31      62.168  73.116   3.722  1.00 40.59           C  \\nANISOU  716  CD  PRO B  31     5233   5084   5104    -58   -308    787       C  \\nATOM    717  N   LYS B  32      58.630  72.473   4.475  1.00 41.97           N  \\nANISOU  717  N   LYS B  32     5360   5349   5236    194   -392    719       N  \\nATOM    718  CA  LYS B  32      57.190  72.740   4.562  1.00 39.36           C  \\nANISOU  718  CA  LYS B  32     5018   5017   4921    301   -423    722       C  \\nATOM    719  C   LYS B  32      56.307  71.516   4.315  1.00 48.25           C  \\nANISOU  719  C   LYS B  32     6075   6285   5972    335   -442    704       C  \\nATOM    720  O   LYS B  32      55.106  71.555   4.597  1.00 44.27           O  \\nANISOU  720  O   LYS B  32     5538   5799   5485    417   -464    684       O  \\nATOM    721  CB  LYS B  32      56.788  73.842   3.574  1.00 37.77           C  \\nANISOU  721  CB  LYS B  32     4866   4736   4750    352   -442    839       C  \\nATOM    722  CG  LYS B  32      57.331  75.224   3.907  1.00 58.55           C  \\nANISOU  722  CG  LYS B  32     7565   7190   7490    338   -423    855       C  \\nATOM    723  CD  LYS B  32      56.564  75.861   5.055  1.00 58.40           C  \\nANISOU  723  CD  LYS B  32     7548   7086   7554    415   -433    766       C  \\nATOM    724  CE  LYS B  32      57.158  77.212   5.436  1.00 67.42           C  \\nANISOU  724  CE  LYS B  32     8759   8039   8820    393   -416    759       C  \\nATOM    725  NZ  LYS B  32      57.822  77.168   6.774  1.00 72.08           N  \\nANISOU  725  NZ  LYS B  32     9339   8601   9446    340   -401    611       N  \\nATOM    726  N   ILE B  33      56.898  70.447   3.781  1.00 43.46           N  \\nANISOU  726  N   ILE B  33     5443   5776   5293    271   -432    707       N  \\nATOM    727  CA  ILE B  33      56.153  69.237   3.418  1.00 31.18           C  \\nANISOU  727  CA  ILE B  33     3823   4346   3677    289   -450    685       C  \\nATOM    728  C   ILE B  33      56.531  68.018   4.245  1.00 29.22           C  \\nANISOU  728  C   ILE B  33     3532   4155   3415    241   -420    600       C  \\nATOM    729  O   ILE B  33      57.623  67.470   4.084  1.00 42.85           O  \\nANISOU  729  O   ILE B  33     5266   5905   5109    172   -396    594       O  \\nATOM    730  CB  ILE B  33      56.360  68.872   1.937  1.00 32.35           C  \\nANISOU  730  CB  ILE B  33     3973   4573   3746    268   -469    755       C  \\nATOM    731  CG1 ILE B  33      55.931  70.034   1.039  1.00 36.56           C  \\nANISOU  731  CG1 ILE B  33     4550   5063   4278    328   -499    860       C  \\nATOM    732  CG2 ILE B  33      55.592  67.598   1.576  1.00 28.49           C  \\nANISOU  732  CG2 ILE B  33     3412   4207   3205    279   -492    709       C  \\nATOM    733  CD1 ILE B  33      55.927  69.682  -0.414  1.00 30.64           C  \\nANISOU  733  CD1 ILE B  33     3798   4415   3428    330   -525    929       C  \\nATOM    734  N   PRO B  34      55.617  67.576   5.123  1.00 28.14           N  \\nANISOU  734  N   PRO B  34     3347   4042   3302    284   -415    542       N  \\nATOM    735  CA  PRO B  34      55.851  66.345   5.889  1.00 25.72           C  \\nANISOU  735  CA  PRO B  34     3000   3791   2982    249   -381    480       C  \\nATOM    736  C   PRO B  34      55.769  65.171   4.931  1.00 31.99           C  \\nANISOU  736  C   PRO B  34     3753   4671   3730    215   -390    485       C  \\nATOM    737  O   PRO B  34      54.850  65.130   4.112  1.00 34.34           O  \\nANISOU  737  O   PRO B  34     4020   5012   4017    248   -427    505       O  \\nATOM    738  CB  PRO B  34      54.670  66.301   6.881  1.00 22.26           C  \\nANISOU  738  CB  PRO B  34     2517   3359   2582    313   -370    438       C  \\nATOM    739  CG  PRO B  34      53.938  67.620   6.720  1.00 32.74           C  \\nANISOU  739  CG  PRO B  34     3866   4625   3948    385   -401    466       C  \\nATOM    740  CD  PRO B  34      54.266  68.115   5.344  1.00 25.11           C  \\nANISOU  740  CD  PRO B  34     2937   3646   2957    371   -438    541       C  \\nATOM    741  N   ILE B  35      56.723  64.252   4.986  1.00 28.08           N  \\nANISOU  741  N   ILE B  35     3256   4204   3209    155   -361    463       N  \\nATOM    742  CA  ILE B  35      56.669  63.102   4.093  1.00 26.48           C  \\nANISOU  742  CA  ILE B  35     3017   4075   2970    125   -367    451       C  \\nATOM    743  C   ILE B  35      56.242  61.848   4.862  1.00 31.91           C  \\nANISOU  743  C   ILE B  35     3649   4787   3688    118   -335    397       C  \\nATOM    744  O   ILE B  35      55.802  60.856   4.285  1.00 37.07           O  \\nANISOU  744  O   ILE B  35     4257   5489   4339    100   -342    371       O  \\nATOM    745  CB  ILE B  35      58.009  62.890   3.351  1.00 42.43           C  \\nANISOU  745  CB  ILE B  35     5070   6111   4941     69   -355    468       C  \\nATOM    746  CG1 ILE B  35      59.133  62.580   4.335  1.00 18.48           C  \\nANISOU  746  CG1 ILE B  35     2049   3051   1922     34   -312    442       C  \\nATOM    747  CG2 ILE B  35      58.364  64.119   2.492  1.00 27.65           C  \\nANISOU  747  CG2 ILE B  35     3249   4214   3041     72   -377    540       C  \\nATOM    748  CD1 ILE B  35      60.442  62.291   3.687  1.00 22.18           C  \\nANISOU  748  CD1 ILE B  35     2533   3543   2350    -18   -295    452       C  \\nATOM    749  N   LYS B  36      56.362  61.912   6.179  1.00 41.12           N  \\nANISOU  749  N   LYS B  36     4821   5920   4884    131   -299    381       N  \\nATOM    750  CA  LYS B  36      56.011  60.790   7.037  1.00 44.91           C  \\nANISOU  750  CA  LYS B  36     5255   6416   5391    129   -255    351       C  \\nATOM    751  C   LYS B  36      55.882  61.308   8.471  1.00 24.29           C  \\nANISOU  751  C   LYS B  36     2656   3779   2794    171   -225    345       C  \\nATOM    752  O   LYS B  36      56.739  62.044   8.949  1.00 38.05           O  \\nANISOU  752  O   LYS B  36     4447   5492   4519    173   -227    343       O  \\nATOM    753  CB  LYS B  36      57.067  59.678   6.926  1.00 33.91           C  \\nANISOU  753  CB  LYS B  36     3866   5036   3980     81   -227    340       C  \\nATOM    754  CG  LYS B  36      56.769  58.414   7.734  1.00 43.25           C  \\nANISOU  754  CG  LYS B  36     5009   6223   5200     78   -175    324       C  \\nATOM    755  CD  LYS B  36      57.766  57.308   7.424  1.00 32.78           C  \\nANISOU  755  CD  LYS B  36     3687   4902   3866     38   -153    314       C  \\nATOM    756  CE  LYS B  36      57.801  56.254   8.524  1.00 35.64           C  \\nANISOU  756  CE  LYS B  36     4031   5249   4261     48    -92    321       C  \\nATOM    757  NZ  LYS B  36      56.473  55.612   8.753  1.00 30.15           N  \\nANISOU  757  NZ  LYS B  36     3279   4548   3630     50    -64    318       N  \\nATOM    758  N   ARG B  37      54.791  60.942   9.133  1.00 29.04           N  \\nANISOU  758  N   ARG B  37     3208   4397   3430    204   -196    335       N  \\nATOM    759  CA  ARG B  37      54.511  61.384  10.497  1.00 44.80           C  \\nANISOU  759  CA  ARG B  37     5208   6385   5427    255   -161    325       C  \\nATOM    760  C   ARG B  37      53.845  60.278  11.294  1.00 34.33           C  \\nANISOU  760  C   ARG B  37     3826   5092   4125    262    -98    328       C  \\nATOM    761  O   ARG B  37      53.177  59.419  10.732  1.00 47.38           O  \\nANISOU  761  O   ARG B  37     5423   6760   5819    234    -90    332       O  \\nATOM    762  CB  ARG B  37      53.593  62.606  10.498  1.00 33.09           C  \\nANISOU  762  CB  ARG B  37     3723   4884   3966    315   -189    319       C  \\nATOM    763  CG  ARG B  37      54.240  63.857   9.998  1.00 39.22           C  \\nANISOU  763  CG  ARG B  37     4564   5607   4731    318   -237    325       C  \\nATOM    764  CD  ARG B  37      53.434  65.056  10.421  1.00 36.08           C  \\nANISOU  764  CD  ARG B  37     4172   5173   4362    391   -248    311       C  \\nATOM    765  NE  ARG B  37      52.176  65.160   9.700  1.00 31.76           N  \\nANISOU  765  NE  ARG B  37     3572   4647   3847    429   -274    330       N  \\nATOM    766  CZ  ARG B  37      51.453  66.273   9.649  1.00 36.25           C  \\nANISOU  766  CZ  ARG B  37     4146   5180   4448    500   -300    333       C  \\nATOM    767  NH1 ARG B  37      51.871  67.364  10.284  1.00 37.35           N  \\nANISOU  767  NH1 ARG B  37     4346   5249   4598    533   -299    310       N  \\nATOM    768  NH2 ARG B  37      50.313  66.299   8.972  1.00 31.73           N  \\nANISOU  768  NH2 ARG B  37     3513   4641   3901    540   -330    352       N  \\nATOM    769  N   GLY B  38      54.005  60.323  12.609  1.00 32.05           N  \\nANISOU  769  N   GLY B  38     3551   4814   3810    300    -51    326       N  \\nATOM    770  CA  GLY B  38      53.401  59.338  13.476  1.00 33.67           C  \\nANISOU  770  CA  GLY B  38     3710   5051   4032    313     23    348       C  \\nATOM    771  C   GLY B  38      54.015  59.332  14.858  1.00 42.00           C  \\nANISOU  771  C   GLY B  38     4801   6133   5025    355     67    353       C  \\nATOM    772  O   GLY B  38      54.599  60.323  15.301  1.00 35.48           O  \\nANISOU  772  O   GLY B  38     4025   5305   4151    386     36    320       O  \\nATOM    773  N   CYS B  39      53.879  58.200  15.537  1.00 41.27           N  \\nANISOU  773  N   CYS B  39     4682   6064   4935    355    138    396       N  \\nATOM    774  CA  CYS B  39      54.396  58.036  16.881  1.00 32.22           C  \\nANISOU  774  CA  CYS B  39     3565   4961   3716    405    185    415       C  \\nATOM    775  C   CYS B  39      55.683  57.253  16.819  1.00 28.87           C  \\nANISOU  775  C   CYS B  39     3174   4530   3265    377    178    440       C  \\nATOM    776  O   CYS B  39      55.904  56.490  15.885  1.00 34.28           O  \\nANISOU  776  O   CYS B  39     3846   5175   4003    320    169    453       O  \\nATOM    777  CB  CYS B  39      53.400  57.262  17.742  1.00 26.35           C  \\nANISOU  777  CB  CYS B  39     2771   4253   2988    435    281    469       C  \\nATOM    778  SG  CYS B  39      51.783  58.013  17.883  1.00 41.68           S  \\nANISOU  778  SG  CYS B  39     4649   6217   4970    475    306    445       S  \\nATOM    779  N   THR B  40      56.524  57.435  17.833  1.00 38.62           N  \\nANISOU  779  N   THR B  40     4449   5810   4415    424    181    438       N  \\nATOM    780  CA  THR B  40      57.781  56.707  17.936  1.00 34.26           C  \\nANISOU  780  CA  THR B  40     3922   5266   3830    415    174    464       C  \\nATOM    781  C   THR B  40      58.203  56.649  19.404  1.00 49.05           C  \\nANISOU  781  C   THR B  40     5817   7218   5602    492    205    484       C  \\nATOM    782  O   THR B  40      57.747  57.467  20.222  1.00 35.32           O  \\nANISOU  782  O   THR B  40     4085   5526   3807    546    210    449       O  \\nATOM    783  CB  THR B  40      58.880  57.382  17.097  1.00 37.31           C  \\nANISOU  783  CB  THR B  40     4336   5627   4212    371     91    409       C  \\nATOM    784  OG1 THR B  40      60.044  56.547  17.058  1.00 37.42           O  \\nANISOU  784  OG1 THR B  40     4359   5650   4208    361     89    435       O  \\nATOM    785  CG2 THR B  40      59.237  58.760  17.679  1.00 34.70           C  \\nANISOU  785  CG2 THR B  40     4038   5323   3824    403     42    340       C  \\nATOM    786  N   ASP B  41      59.055  55.683  19.745  1.00 43.03           N  \\nANISOU  786  N   ASP B  41     5065   6475   4811    507    225    537       N  \\nATOM    787  CA  ASP B  41      59.594  55.629  21.105  1.00 42.89           C  \\nANISOU  787  CA  ASP B  41     5069   6549   4678    589    241    559       C  \\nATOM    788  C   ASP B  41      60.924  56.372  21.224  1.00 41.54           C  \\nANISOU  788  C   ASP B  41     4923   6419   4441    596    152    484       C  \\nATOM    789  O   ASP B  41      61.079  57.262  22.062  1.00 47.34           O  \\nANISOU  789  O   ASP B  41     5675   7221   5092    644    121    422       O  \\nATOM    790  CB  ASP B  41      59.667  54.194  21.662  1.00 36.98           C  \\nANISOU  790  CB  ASP B  41     4315   5813   3923    626    320    675       C  \\nATOM    791  CG  ASP B  41      60.650  53.305  20.929  1.00 80.83           C  \\nANISOU  791  CG  ASP B  41     9869  11314   9527    590    300    702       C  \\nATOM    792  OD1 ASP B  41      61.376  52.569  21.631  1.00101.38           O  \\nANISOU  792  OD1 ASP B  41    12486  13960  12074    649    321    768       O  \\nATOM    793  OD2 ASP B  41      60.689  53.306  19.671  1.00 77.77           O  \\nANISOU  793  OD2 ASP B  41     9469  10850   9229    512    267    663       O  \\nATOM    794  N   ALA B  42      61.878  56.029  20.372  1.00 35.31           N  \\nANISOU  794  N   ALA B  42     4131   5591   3693    545    112    480       N  \\nATOM    795  CA  ALA B  42      63.118  56.792  20.294  1.00 44.38           C  \\nANISOU  795  CA  ALA B  42     5288   6768   4805    531     29    404       C  \\nATOM    796  C   ALA B  42      63.111  57.601  18.994  1.00 43.68           C  \\nANISOU  796  C   ALA B  42     5198   6599   4797    444    -18    346       C  \\nATOM    797  O   ALA B  42      62.655  57.111  17.961  1.00 26.34           O  \\nANISOU  797  O   ALA B  42     2992   4338   2679    395      4    378       O  \\nATOM    798  CB  ALA B  42      64.322  55.861  20.371  1.00 23.86           C  \\nANISOU  798  CB  ALA B  42     2680   4203   2183    549     21    445       C  \\nATOM    799  N   CYS B  43      63.580  58.844  19.057  1.00 47.72           N  \\nANISOU  799  N   CYS B  43     5722   7117   5292    427    -80    261       N  \\nATOM    800  CA  CYS B  43      63.578  59.715  17.881  1.00 43.35           C  \\nANISOU  800  CA  CYS B  43     5174   6486   4812    351   -119    221       C  \\nATOM    801  C   CYS B  43      64.487  59.185  16.782  1.00 43.38           C  \\nANISOU  801  C   CYS B  43     5162   6463   4857    290   -132    243       C  \\nATOM    802  O   CYS B  43      65.691  58.984  17.003  1.00 41.61           O  \\nANISOU  802  O   CYS B  43     4923   6283   4603    289   -158    229       O  \\nATOM    803  CB  CYS B  43      64.020  61.137  18.240  1.00 27.06           C  \\nANISOU  803  CB  CYS B  43     3128   4420   2734    343   -178    127       C  \\nATOM    804  SG  CYS B  43      63.674  62.341  16.937  1.00 30.45           S  \\nANISOU  804  SG  CYS B  43     3575   4737   3258    268   -208    101       S  \\nATOM    805  N   PRO B  44      63.918  58.963  15.589  1.00 46.27           N  \\nANISOU  805  N   PRO B  44     5525   6768   5286    242   -117    272       N  \\nATOM    806  CA  PRO B  44      64.705  58.491  14.439  1.00 44.41           C  \\nANISOU  806  CA  PRO B  44     5276   6514   5084    187   -124    286       C  \\nATOM    807  C   PRO B  44      65.811  59.479  14.055  1.00 39.71           C  \\nANISOU  807  C   PRO B  44     4681   5916   4490    137   -174    240       C  \\nATOM    808  O   PRO B  44      65.670  60.696  14.211  1.00 52.63           O  \\nANISOU  808  O   PRO B  44     6335   7526   6134    124   -204    198       O  \\nATOM    809  CB  PRO B  44      63.662  58.387  13.318  1.00 37.49           C  \\nANISOU  809  CB  PRO B  44     4401   5584   4261    153   -110    307       C  \\nATOM    810  CG  PRO B  44      62.346  58.249  14.035  1.00 37.15           C  \\nANISOU  810  CG  PRO B  44     4356   5538   4221    200    -76    324       C  \\nATOM    811  CD  PRO B  44      62.484  59.080  15.276  1.00 30.25           C  \\nANISOU  811  CD  PRO B  44     3499   4699   3296    247    -91    290       C  \\nATOM    812  N   LYS B  45      66.913  58.939  13.554  1.00 37.61           N  \\nANISOU  812  N   LYS B  45     4391   5674   4226    110   -176    246       N  \\nATOM    813  CA  LYS B  45      68.052  59.736  13.143  1.00 44.38           C  \\nANISOU  813  CA  LYS B  45     5233   6535   5093     55   -211    210       C  \\nATOM    814  C   LYS B  45      67.792  60.449  11.828  1.00 35.76           C  \\nANISOU  814  C   LYS B  45     4158   5383   4044    -10   -213    222       C  \\nATOM    815  O   LYS B  45      67.149  59.906  10.919  1.00 29.01           O  \\nANISOU  815  O   LYS B  45     3311   4509   3203    -17   -189    258       O  \\nATOM    816  CB  LYS B  45      69.308  58.869  12.943  1.00 60.45           C  \\nANISOU  816  CB  LYS B  45     7227   8624   7119     52   -205    217       C  \\nATOM    817  CG  LYS B  45      69.351  57.475  13.552  1.00 78.92           C  \\nANISOU  817  CG  LYS B  45     9552  11003   9431    122   -175    253       C  \\nATOM    818  CD  LYS B  45      68.709  56.247  12.888  1.00 87.11           C  \\nANISOU  818  CD  LYS B  45    10596  12005  10497    135   -125    302       C  \\nATOM    819  CE  LYS B  45      67.187  56.091  12.888  1.00 50.55           C  \\nANISOU  819  CE  LYS B  45     5994   7324   5886    146    -97    327       C  \\nATOM    820  NZ  LYS B  45      66.833  54.899  12.064  1.00 42.78           N  \\nANISOU  820  NZ  LYS B  45     5003   6305   4945    139    -57    353       N  \\nATOM    821  N   SER B  46      68.328  61.653  11.703  1.00 31.26           N  \\nANISOU  821  N   SER B  46     3592   4786   3498    -59   -242    191       N  \\nATOM    822  CA  SER B  46      68.324  62.323  10.405  1.00 35.39           C  \\nANISOU  822  CA  SER B  46     4131   5260   4058   -121   -237    221       C  \\nATOM    823  C   SER B  46      69.269  61.650   9.408  1.00 35.34           C  \\nANISOU  823  C   SER B  46     4091   5292   4044   -160   -213    246       C  \\nATOM    824  O   SER B  46      70.139  60.867   9.786  1.00 50.43           O  \\nANISOU  824  O   SER B  46     5962   7263   5937   -146   -207    230       O  \\nATOM    825  CB  SER B  46      68.707  63.784  10.579  1.00 25.69           C  \\nANISOU  825  CB  SER B  46     2915   3975   2871   -167   -265    188       C  \\nATOM    826  OG  SER B  46      67.655  64.478  11.238  1.00 49.65           O  \\nANISOU  826  OG  SER B  46     5987   6959   5917   -126   -282    165       O  \\nATOM    827  N   SER B  47      69.082  61.947   8.129  1.00 27.37           N  \\nANISOU  827  N   SER B  47     3099   4259   3044   -199   -198    288       N  \\nATOM    828  CA  SER B  47      70.040  61.541   7.103  1.00 27.00           C  \\nANISOU  828  CA  SER B  47     3021   4254   2984   -240   -170    308       C  \\nATOM    829  C   SER B  47      70.473  62.775   6.309  1.00 34.37           C  \\nANISOU  829  C   SER B  47     3965   5149   3944   -310   -164    341       C  \\nATOM    830  O   SER B  47      70.051  63.899   6.611  1.00 36.96           O  \\nANISOU  830  O   SER B  47     4327   5407   4311   -324   -186    343       O  \\nATOM    831  CB  SER B  47      69.432  60.484   6.168  1.00 26.17           C  \\nANISOU  831  CB  SER B  47     2922   4174   2846   -216   -145    331       C  \\nATOM    832  OG  SER B  47      68.525  61.071   5.235  1.00 37.63           O  \\nANISOU  832  OG  SER B  47     4413   5595   4291   -226   -150    370       O  \\nATOM    833  N   LEU B  48      71.319  62.566   5.307  1.00 19.21           N  \\nANISOU  833  N   LEU B  48     2018   3272   2009   -351   -129    368       N  \\nATOM    834  CA  LEU B  48      71.726  63.643   4.411  1.00 38.49           C  \\nANISOU  834  CA  LEU B  48     4470   5681   4471   -418   -108    421       C  \\nATOM    835  C   LEU B  48      70.566  64.275   3.641  1.00 29.34           C  \\nANISOU  835  C   LEU B  48     3376   4470   3300   -406   -113    483       C  \\nATOM    836  O   LEU B  48      70.666  65.416   3.208  1.00 43.50           O  \\nANISOU  836  O   LEU B  48     5195   6204   5128   -450   -104    535       O  \\nATOM    837  CB  LEU B  48      72.750  63.135   3.394  1.00 39.57           C  \\nANISOU  837  CB  LEU B  48     4564   5896   4576   -452    -57    445       C  \\nATOM    838  CG  LEU B  48      74.216  63.024   3.808  1.00 56.16           C  \\nANISOU  838  CG  LEU B  48     6587   8044   6706   -493    -41    407       C  \\nATOM    839  CD1 LEU B  48      75.078  63.749   2.794  1.00 69.96           C  \\nANISOU  839  CD1 LEU B  48     8311   9802   8468   -573     12    464       C  \\nATOM    840  CD2 LEU B  48      74.443  63.587   5.203  1.00 73.90           C  \\nANISOU  840  CD2 LEU B  48     8817  10251   9012   -502    -89    348       C  \\nATOM    841  N   LEU B  49      69.480  63.526   3.459  1.00 26.85           N  \\nANISOU  841  N   LEU B  49     3083   4176   2943   -345   -127    480       N  \\nATOM    842  CA  LEU B  49      68.342  63.988   2.660  1.00 35.13           C  \\nANISOU  842  CA  LEU B  49     4180   5197   3969   -321   -140    535       C  \\nATOM    843  C   LEU B  49      67.092  64.267   3.478  1.00 33.49           C  \\nANISOU  843  C   LEU B  49     4000   4932   3792   -269   -181    514       C  \\nATOM    844  O   LEU B  49      66.201  64.990   3.030  1.00 35.20           O  \\nANISOU  844  O   LEU B  49     4255   5108   4012   -247   -199    560       O  \\nATOM    845  CB  LEU B  49      68.001  62.960   1.578  1.00 24.12           C  \\nANISOU  845  CB  LEU B  49     2780   3885   2500   -296   -128    542       C  \\nATOM    846  CG  LEU B  49      68.998  62.834   0.426  1.00 29.12           C  \\nANISOU  846  CG  LEU B  49     3397   4585   3082   -335    -83    577       C  \\nATOM    847  CD1 LEU B  49      68.595  61.712  -0.501  1.00 31.89           C  \\nANISOU  847  CD1 LEU B  49     3740   5020   3356   -300    -78    554       C  \\nATOM    848  CD2 LEU B  49      69.080  64.141  -0.339  1.00 23.18           C  \\nANISOU  848  CD2 LEU B  49     2682   3798   2328   -369    -68    672       C  \\nATOM    849  N   VAL B  50      67.023  63.684   4.670  1.00 37.11           N  \\nANISOU  849  N   VAL B  50     4437   5395   4268   -241   -192    450       N  \\nATOM    850  CA  VAL B  50      65.819  63.761   5.499  1.00 23.74           C  \\nANISOU  850  CA  VAL B  50     2759   3667   2593   -185   -218    426       C  \\nATOM    851  C   VAL B  50      66.091  64.361   6.880  1.00 33.57           C  \\nANISOU  851  C   VAL B  50     4006   4870   3879   -180   -233    377       C  \\nATOM    852  O   VAL B  50      67.027  63.968   7.590  1.00 45.68           O  \\nANISOU  852  O   VAL B  50     5509   6438   5410   -193   -228    335       O  \\nATOM    853  CB  VAL B  50      65.169  62.362   5.635  1.00 35.76           C  \\nANISOU  853  CB  VAL B  50     4256   5242   4088   -144   -212    401       C  \\nATOM    854  CG1 VAL B  50      64.070  62.355   6.682  1.00 37.18           C  \\nANISOU  854  CG1 VAL B  50     4439   5397   4291    -90   -225    376       C  \\nATOM    855  CG2 VAL B  50      64.634  61.908   4.273  1.00 28.95           C  \\nANISOU  855  CG2 VAL B  50     3395   4418   3188   -143   -212    430       C  \\nATOM    856  N   LYS B  51      65.273  65.339   7.244  1.00 28.20           N  \\nANISOU  856  N   LYS B  51     3359   4122   3234   -153   -254    376       N  \\nATOM    857  CA  LYS B  51      65.276  65.886   8.593  1.00 27.54           C  \\nANISOU  857  CA  LYS B  51     3280   4005   3180   -132   -271    312       C  \\nATOM    858  C   LYS B  51      64.160  65.233   9.415  1.00 27.97           C  \\nANISOU  858  C   LYS B  51     3327   4089   3210    -58   -271    287       C  \\nATOM    859  O   LYS B  51      63.055  65.007   8.899  1.00 31.28           O  \\nANISOU  859  O   LYS B  51     3751   4509   3626    -24   -269    320       O  \\nATOM    860  CB  LYS B  51      65.103  67.409   8.545  1.00 26.22           C  \\nANISOU  860  CB  LYS B  51     3153   3732   3075   -145   -288    316       C  \\nATOM    861  CG  LYS B  51      64.881  68.062   9.900  1.00 54.91           C  \\nANISOU  861  CG  LYS B  51     6798   7326   6739   -110   -309    234       C  \\nATOM    862  CD  LYS B  51      66.061  67.810  10.829  1.00 78.81           C  \\nANISOU  862  CD  LYS B  51     9792  10400   9754   -141   -318    161       C  \\nATOM    863  CE  LYS B  51      67.367  68.302  10.216  1.00 91.71           C  \\nANISOU  863  CE  LYS B  51    11409  12006  11429   -234   -315    172       C  \\nATOM    864  NZ  LYS B  51      68.533  67.955  11.068  1.00 91.52           N  \\nANISOU  864  NZ  LYS B  51    11335  12048  11390   -259   -330     98       N  \\nATOM    865  N   VAL B  52      64.453  64.914  10.682  1.00 41.42           N  \\nANISOU  865  N   VAL B  52     5015   5828   4895    -31   -271    230       N  \\nATOM    866  CA  VAL B  52      63.447  64.368  11.606  1.00 35.60           C  \\nANISOU  866  CA  VAL B  52     4271   5122   4133     40   -259    213       C  \\nATOM    867  C   VAL B  52      63.252  65.240  12.864  1.00 43.09           C  \\nANISOU  867  C   VAL B  52     5237   6051   5085     81   -275    145       C  \\nATOM    868  O   VAL B  52      64.171  65.355  13.684  1.00 48.02           O  \\nANISOU  868  O   VAL B  52     5854   6704   5689     74   -289     91       O  \\nATOM    869  CB  VAL B  52      63.804  62.937  12.060  1.00 28.23           C  \\nANISOU  869  CB  VAL B  52     3304   4266   3155     56   -232    219       C  \\nATOM    870  CG1 VAL B  52      62.609  62.288  12.748  1.00 28.03           C  \\nANISOU  870  CG1 VAL B  52     3269   4265   3115    120   -203    229       C  \\nATOM    871  CG2 VAL B  52      64.276  62.093  10.887  1.00 17.62           C  \\nANISOU  871  CG2 VAL B  52     1943   2942   1811     13   -218    261       C  \\nATOM    872  N   VAL B  53      62.070  65.857  13.001  1.00 47.96           N  \\nANISOU  872  N   VAL B  53     5872   6625   5725    129   -275    141       N  \\nATOM    873  CA  VAL B  53      61.658  66.538  14.245  1.00 32.61           C  \\nANISOU  873  CA  VAL B  53     3942   4675   3775    188   -280     69       C  \\nATOM    874  C   VAL B  53      61.021  65.531  15.198  1.00 34.00           C  \\nANISOU  874  C   VAL B  53     4091   4937   3889    253   -243     70       C  \\nATOM    875  O   VAL B  53      60.269  64.648  14.779  1.00 44.02           O  \\nANISOU  875  O   VAL B  53     5336   6232   5157    264   -212    129       O  \\nATOM    876  CB  VAL B  53      60.654  67.736  14.000  1.00 85.12           C  \\nANISOU  876  CB  VAL B  53    10622  11235  10484    222   -292     61       C  \\nATOM    877  CG1 VAL B  53      59.205  67.484  14.602  1.00 25.10           C  \\nANISOU  877  CG1 VAL B  53     3003   3669   2866    310   -263     58       C  \\nATOM    878  CG2 VAL B  53      61.233  69.020  14.551  1.00 85.78           C  \\nANISOU  878  CG2 VAL B  53    10739  11245  10607    212   -323    -21       C  \\nATOM    879  N   CYS B  54      61.329  65.656  16.479  1.00 36.68           N  \\nANISOU  879  N   CYS B  54     4434   5325   4178    294   -245      5       N  \\nATOM    880  CA  CYS B  54      60.600  64.908  17.493  1.00 32.77           C  \\nANISOU  880  CA  CYS B  54     3921   4911   3620    368   -200     13       C  \\nATOM    881  C   CYS B  54      60.146  65.854  18.591  1.00 32.61           C  \\nANISOU  881  C   CYS B  54     3920   4897   3574    436   -205    -74       C  \\nATOM    882  O   CYS B  54      60.869  66.782  18.966  1.00 41.41           O  \\nANISOU  882  O   CYS B  54     5058   5986   4692    424   -251   -160       O  \\nATOM    883  CB  CYS B  54      61.449  63.765  18.061  1.00 34.88           C  \\nANISOU  883  CB  CYS B  54     4168   5267   3817    371   -186     37       C  \\nATOM    884  SG  CYS B  54      61.630  62.348  16.926  1.00 35.72           S  \\nANISOU  884  SG  CYS B  54     4248   5372   3953    319   -157    138       S  \\nATOM    885  N   CYS B  55      58.941  65.623  19.099  1.00 31.10           N  \\nANISOU  885  N   CYS B  55     3714   4739   3362    505   -157    -58       N  \\nATOM    886  CA  CYS B  55      58.366  66.475  20.130  1.00 29.03           C  \\nANISOU  886  CA  CYS B  55     3467   4493   3070    583   -151   -142       C  \\nATOM    887  C   CYS B  55      57.407  65.619  20.964  1.00 36.84           C  \\nANISOU  887  C   CYS B  55     4425   5580   3994    658    -75    -99       C  \\nATOM    888  O   CYS B  55      57.002  64.531  20.529  1.00 27.52           O  \\nANISOU  888  O   CYS B  55     3211   4420   2827    638    -31     -3       O  \\nATOM    889  CB  CYS B  55      57.639  67.645  19.481  1.00 22.49           C  \\nANISOU  889  CB  CYS B  55     2655   3555   2334    589   -172   -170       C  \\nATOM    890  SG  CYS B  55      56.421  67.108  18.255  1.00 32.55           S  \\nANISOU  890  SG  CYS B  55     3892   4798   3679    578   -141    -60       S  \\nATOM    891  N   ASN B  56      57.052  66.086  22.160  1.00 42.59           N  \\nANISOU  891  N   ASN B  56     5162   6369   4653    741    -55   -172       N  \\nATOM    892  CA  ASN B  56      56.300  65.236  23.084  1.00 41.38           C  \\nANISOU  892  CA  ASN B  56     4979   6325   4419    813     27   -123       C  \\nATOM    893  C   ASN B  56      55.027  65.824  23.687  1.00 42.90           C  \\nANISOU  893  C   ASN B  56     5156   6540   4604    900     77   -165       C  \\nATOM    894  O   ASN B  56      54.570  65.367  24.735  1.00 45.08           O  \\nANISOU  894  O   ASN B  56     5415   6925   4787    974    145   -151       O  \\nATOM    895  CB  ASN B  56      57.210  64.693  24.196  1.00 48.83           C  \\nANISOU  895  CB  ASN B  56     5936   7385   5233    848     30   -135       C  \\nATOM    896  CG  ASN B  56      57.917  65.794  24.966  1.00 69.44           C  \\nANISOU  896  CG  ASN B  56     8582  10016   7784    881    -35   -279       C  \\nATOM    897  OD1 ASN B  56      57.709  66.983  24.707  1.00 84.25           O  \\nANISOU  897  OD1 ASN B  56    10479  11806   9728    877    -74   -372       O  \\nATOM    898  ND2 ASN B  56      58.758  65.403  25.923  1.00 54.30           N  \\nANISOU  898  ND2 ASN B  56     6673   8214   5745    917    -48   -302       N  \\nATOM    899  N   LYS B  57      54.456  66.831  23.036  1.00 40.72           N  \\nANISOU  899  N   LYS B  57     4884   6165   4422    900     47   -210       N  \\nATOM    900  CA  LYS B  57      53.116  67.281  23.405  1.00 51.14           C  \\nANISOU  900  CA  LYS B  57     6174   7501   5757    984    100   -234       C  \\nATOM    901  C   LYS B  57      52.111  66.851  22.336  1.00 46.04           C  \\nANISOU  901  C   LYS B  57     5472   6810   5211    953    124   -140       C  \\nATOM    902  O   LYS B  57      52.494  66.504  21.218  1.00 36.44           O  \\nANISOU  902  O   LYS B  57     4255   5531   4059    870     84    -81       O  \\nATOM    903  CB  LYS B  57      53.055  68.798  23.675  1.00 46.19           C  \\nANISOU  903  CB  LYS B  57     5588   6805   5157   1037     55   -368       C  \\nATOM    904  CG  LYS B  57      53.683  69.675  22.612  1.00 64.53           C  \\nANISOU  904  CG  LYS B  57     7952   8980   7588    966    -31   -394       C  \\nATOM    905  CD  LYS B  57      55.096  70.080  23.014  1.00 73.37           C  \\nANISOU  905  CD  LYS B  57     9123  10087   8669    924    -93   -481       C  \\nATOM    906  CE  LYS B  57      56.024  70.225  21.814  1.00 62.62           C  \\nANISOU  906  CE  LYS B  57     7783   8618   7393    813   -156   -439       C  \\nATOM    907  NZ  LYS B  57      57.424  69.809  22.168  1.00 63.61           N  \\nANISOU  907  NZ  LYS B  57     7921   8795   7454    755   -192   -464       N  \\nATOM    908  N   ASP B  58      50.831  66.845  22.693  1.00 32.23           N  \\nANISOU  908  N   ASP B  58     3668   5106   3472   1023    191   -131       N  \\nATOM    909  CA  ASP B  58      49.782  66.390  21.774  1.00 43.23           C  \\nANISOU  909  CA  ASP B  58     4990   6478   4958    999    214    -51       C  \\nATOM    910  C   ASP B  58      49.795  67.089  20.414  1.00 39.99           C  \\nANISOU  910  C   ASP B  58     4593   5949   4652    957    130    -51       C  \\nATOM    911  O   ASP B  58      49.765  68.322  20.331  1.00 25.31           O  \\nANISOU  911  O   ASP B  58     2772   4018   2827   1001     85   -122       O  \\nATOM    912  CB  ASP B  58      48.400  66.541  22.421  1.00 47.82           C  \\nANISOU  912  CB  ASP B  58     5503   7126   5541   1092    293    -63       C  \\nATOM    913  CG  ASP B  58      47.916  65.263  23.083  1.00 51.38           C  \\nANISOU  913  CG  ASP B  58     5891   7686   5944   1092    399     19       C  \\nATOM    914  OD1 ASP B  58      48.742  64.352  23.327  1.00 47.31           O  \\nANISOU  914  OD1 ASP B  58     5402   7201   5371   1042    413     73       O  \\nATOM    915  OD2 ASP B  58      46.704  65.174  23.364  1.00 67.10           O  \\nANISOU  915  OD2 ASP B  58     7803   9730   7961   1143    472     35       O  \\nATOM    916  N   LYS B  59      49.842  66.285  19.356  1.00 33.36           N  \\nANISOU  916  N   LYS B  59     3725   5091   3861    876    112     29       N  \\nATOM    917  CA  LYS B  59      49.729  66.784  17.986  1.00 40.93           C  \\nANISOU  917  CA  LYS B  59     4686   5962   4903    841     41     50       C  \\nATOM    918  C   LYS B  59      50.759  67.864  17.662  1.00 47.45           C  \\nANISOU  918  C   LYS B  59     5599   6691   5738    823    -32      3       C  \\nATOM    919  O   LYS B  59      50.489  68.782  16.871  1.00 39.44           O  \\nANISOU  919  O   LYS B  59     4602   5595   4790    839    -82      2       O  \\nATOM    920  CB  LYS B  59      48.322  67.334  17.719  1.00 47.02           C  \\nANISOU  920  CB  LYS B  59     5393   6731   5740    913     48     45       C  \\nATOM    921  CG  LYS B  59      47.198  66.301  17.738  1.00 54.33           C  \\nANISOU  921  CG  LYS B  59     6212   7741   6690    913    112     96       C  \\nATOM    922  CD  LYS B  59      45.920  66.910  17.170  1.00 55.75           C  \\nANISOU  922  CD  LYS B  59     6322   7914   6948    975     93     92       C  \\nATOM    923  CE  LYS B  59      44.718  66.014  17.370  1.00 60.43           C  \\nANISOU  923  CE  LYS B  59     6790   8597   7573    981    164    125       C  \\nATOM    924  NZ  LYS B  59      43.500  66.671  16.824  1.00 68.69           N  \\nANISOU  924  NZ  LYS B  59     7758   9646   8695   1051    137    115       N  \\nATOM    925  N   CYS B  60      51.934  67.741  18.272  1.00 32.59           N  \\nANISOU  925  N   CYS B  60     3770   4821   3794    790    -38    -29       N  \\nATOM    926  CA  CYS B  60      52.964  68.758  18.173  1.00 37.12           C  \\nANISOU  926  CA  CYS B  60     4416   5308   4380    767    -98    -88       C  \\nATOM    927  C   CYS B  60      53.772  68.630  16.898  1.00 28.86           C  \\nANISOU  927  C   CYS B  60     3393   4200   3374    672   -149    -29       C  \\nATOM    928  O   CYS B  60      54.590  69.492  16.590  1.00 36.38           O  \\nANISOU  928  O   CYS B  60     4399   5067   4357    639   -196    -59       O  \\nATOM    929  CB  CYS B  60      53.909  68.639  19.357  1.00 26.48           C  \\nANISOU  929  CB  CYS B  60     3101   4016   2946    770    -89   -155       C  \\nATOM    930  SG  CYS B  60      54.767  67.078  19.417  1.00 34.40           S  \\nANISOU  930  SG  CYS B  60     4085   5108   3877    702    -66    -82       S  \\nATOM    931  N   ASN B  61      53.570  67.532  16.181  1.00 34.85           N  \\nANISOU  931  N   ASN B  61     4109   5002   4131    627   -135     51       N  \\nATOM    932  CA  ASN B  61      54.320  67.277  14.952  1.00 40.98           C  \\nANISOU  932  CA  ASN B  61     4902   5742   4929    543   -176    106       C  \\nATOM    933  C   ASN B  61      53.527  67.681  13.714  1.00 38.08           C  \\nANISOU  933  C   ASN B  61     4519   5329   4621    550   -208    156       C  \\nATOM    934  O   ASN B  61      52.620  68.505  13.824  1.00 38.33           O  \\nANISOU  934  O   ASN B  61     4543   5329   4692    622   -213    138       O  \\nATOM    935  CB  ASN B  61      54.758  65.809  14.868  1.00 36.22           C  \\nANISOU  935  CB  ASN B  61     4268   5210   4284    487   -147    151       C  \\nATOM    936  CG  ASN B  61      53.595  64.859  14.660  1.00 35.41           C  \\nANISOU  936  CG  ASN B  61     4095   5160   4200    501   -108    194       C  \\nATOM    937  OD1 ASN B  61      52.454  65.157  15.013  1.00 39.72           O  \\nANISOU  937  OD1 ASN B  61     4604   5721   4768    564    -85    183       O  \\nATOM    938  ND2 ASN B  61      53.885  63.704  14.085  1.00 22.34           N  \\nANISOU  938  ND2 ASN B  61     2415   3530   2541    441    -99    238       N  \\nATOM    939  OXT ASN B  61      53.771  67.207  12.599  1.00 27.54           O  \\nANISOU  939  OXT ASN B  61     3177   3996   3292    493   -232    212       O  \\nTER     940      ASN B  61                                                      \\nHETATM  941  O   HOH A 101      74.826  53.239   3.395  1.00 22.77           O  \\nHETATM  942  O   HOH A 102      63.231  58.783  -3.483  1.00 25.28           O  \\nHETATM  943  O   HOH A 103      73.299  55.368  -3.080  1.00 26.84           O  \\nHETATM  944  O   HOH A 104      61.514  52.082  -0.408  1.00 31.79           O  \\nHETATM  945  O   HOH A 105      59.257  54.188  -4.092  1.00 26.51           O  \\nHETATM  946  O   HOH A 106      73.623  43.081  26.104  1.00 35.69           O  \\nHETATM  947  O   HOH A 107      78.304  54.113   8.025  1.00 38.66           O  \\nHETATM  948  O   HOH A 108      58.727  45.532   3.585  1.00 41.75           O  \\nHETATM  949  O   HOH A 109      70.446  56.833   6.300  1.00 35.79           O  \\nHETATM  950  O   HOH A 110      64.991  36.479   3.699  1.00 41.95           O  \\nHETATM  951  O   HOH A 111      70.670  42.742  15.677  1.00 35.42           O  \\nHETATM  952  O   HOH A 112      81.363  50.971   6.892  1.00 34.84           O  \\nHETATM  953  O   HOH A 113      82.811  49.323   5.484  1.00 38.20           O  \\nHETATM  954  O   HOH A 114      69.052  40.833  18.157  1.00 37.88           O  \\nHETATM  955  O   HOH A 115      63.711  50.599  15.551  1.00 35.91           O  \\nHETATM  956  O   HOH A 116      65.484  52.258  13.751  1.00 32.16           O  \\nHETATM  957  O   HOH A 117      63.491  42.646  14.117  1.00 35.54           O  \\nHETATM  958  O   HOH A 118      85.178  48.471   5.216  1.00 35.21           O  \\nHETATM  959  O   HOH A 119      80.115  48.497   4.430  1.00 34.44           O  \\nHETATM  960  O   HOH A 120      71.140  45.925  -1.602  1.00 42.34           O  \\nHETATM  961  O   HOH B 101      52.598  53.756  15.975  1.00 18.32           O  \\nHETATM  962  O   HOH B 102      49.302  50.174  22.944  1.00 29.63           O  \\nHETATM  963  O   HOH B 103      54.960  62.281  25.517  1.00 23.82           O  \\nHETATM  964  O   HOH B 104      61.168  67.348   9.729  1.00 26.40           O  \\nHETATM  965  O   HOH B 105      49.709  57.223  23.826  1.00 32.14           O  \\nHETATM  966  O   HOH B 106      52.767  59.258   7.687  1.00 25.09           O  \\nHETATM  967  O   HOH B 107      63.285  70.140   6.424  1.00 47.22           O  \\nHETATM  968  O   HOH B 108      59.616  71.152   8.662  1.00 56.53           O  \\nHETATM  969  O   HOH B 109      66.877  56.706  18.054  1.00 36.51           O  \\nHETATM  970  O   HOH B 110      50.733  60.161  26.570  1.00 42.81           O  \\nHETATM  971  O   HOH B 111      59.697  67.987   2.378  1.00 30.71           O  \\nHETATM  972  O   HOH B 112      44.843  59.342  10.776  1.00 35.60           O  \\nHETATM  973  O   HOH B 113      53.213  60.672  26.684  1.00 42.95           O  \\nHETATM  974  O   HOH B 114      56.156  70.611   7.874  1.00 34.65           O  \\nHETATM  975  O   HOH B 115      51.766  55.791  24.122  1.00 35.19           O  \\nHETATM  976  O   HOH B 116      53.194  56.580  10.270  1.00 43.06           O  \\nHETATM  977  O   HOH B 117      57.713  54.137  15.381  1.00 48.65           O  \\nHETATM  978  O   HOH B 118      57.898  74.940   7.339  1.00 28.14           O  \\nHETATM  979  O   HOH B 119      59.142  57.634  24.089  1.00 52.38           O  \\nHETATM  980  O   HOH B 120      61.481  69.904  10.940  1.00 33.94           O  \\nHETATM  981  O   HOH B 121      59.265  55.850  25.363  1.00 46.67           O  \\nHETATM  982  O   HOH B 122      52.070  51.440  14.411  1.00 51.67           O  \\nHETATM  983  O   HOH B 123      42.965  59.027  18.585  1.00 41.48           O  \\nHETATM  984  O   HOH B 124      63.400  71.147  10.372  1.00 46.17           O  \\nHETATM  985  O   HOH B 125      50.060  57.816  28.365  1.00 43.81           O  \\nHETATM  986  O   HOH B 126      46.529  60.864  24.401  1.00 36.51           O  \\nHETATM  987  O   HOH B 127      63.974  66.922  17.310  1.00 25.94           O  \\nHETATM  988  O   HOH B 128      57.982  71.615  12.191  1.00 52.48           O  \\nHETATM  989  O   HOH B 129      48.760  51.806  17.377  1.00 49.01           O  \\nCONECT   23  170                                                                \\nCONECT  119  308                                                                \\nCONECT  170   23                                                                \\nCONECT  308  119                                                                \\nCONECT  334  414                                                                \\nCONECT  414  334                                                                \\nCONECT  420  460                                                                \\nCONECT  460  420                                                                \\nCONECT  493  640                                                                \\nCONECT  589  778                                                                \\nCONECT  640  493                                                                \\nCONECT  778  589                                                                \\nCONECT  804  884                                                                \\nCONECT  884  804                                                                \\nCONECT  890  930                                                                \\nCONECT  930  890                                                                \\nMASTER      240    0    0    0   10    0    0    6  987    2   16   10          \\nEND                                                                             \\n\",\"pdb\");\n",
              "\tviewer_1725285451326232.setStyle({\"cartoon\": {\"color\": \"spectrum\"}});\n",
              "\tviewer_1725285451326232.setBackgroundColor(\"white\");\n",
              "\tviewer_1725285451326232.zoomTo();\n",
              "\tviewer_1725285451326232.zoom(2,800);\n",
              "viewer_1725285451326232.render();\n",
              "});\n",
              "</script>"
            ]
          },
          "metadata": {}
        }
      ],
      "source": [
        "import py3Dmol\n",
        "import requests\n",
        "\n",
        "def fetch_pdb(pdb_id):\n",
        "    url = f'https://files.rcsb.org/download/{pdb_id}.pdb'\n",
        "    response = requests.get(url)\n",
        "    return response.text\n",
        "\n",
        "pdb = fetch_pdb(\"3VTS\")\n",
        "\n",
        "pdbview = py3Dmol.view()\n",
        "pdbview.addModel(pdb, \"pdb\")\n",
        "pdbview.setStyle({\"cartoon\": {\"color\": \"spectrum\"}})\n",
        "pdbview.setBackgroundColor(\"white\")\n",
        "pdbview.zoomTo()\n",
        "pdbview.zoom(2, 800)\n",
        "pdbview.show()"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "0avzYmVrPFM2"
      },
      "source": [
        "## 1.4 Machine Learning and Proteins\n",
        "\n",
        "In the realm of machine learning, proteins present an interesting challenge. The wide range of structures and functions of proteins offers a vast playground for prediction tasks. Proteins can be represented in various ways (e.g., sequences, structures) which can be used to train machine learning models for tasks such as:\n",
        "\n",
        "* **Protein Classification**: Classifying proteins into their respective families\n",
        " based on their amino acid sequences.\n",
        "\n",
        "* **Protein Structure Prediction**: Predicting the 3D structure of a protein from its amino acid sequence (e.g. AlphaFold 2).\n",
        "\n",
        "* **Protein Function Prediction**: Predicting the function of a protein based on its sequence or structure.\n",
        "\n",
        "* **Protein-Protein Interaction Prediction**: Predicting how proteins will interact with each other."
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "7R_xOsqLWFjX"
      },
      "source": [
        "🥜 **In a nutshell**:\n",
        "- Proteins are super important for tons of different things in the body. We can use machine learning to learn more about them!\n",
        "- Proteins are made up of many building blocks which together form complex structures.\n",
        "- Proteins are dynamic and constantly shifting around in the body."
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "bfhR4n8pf48O"
      },
      "source": [
        "# 2. **Representation of Proteins**"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "89FPaYNHgJeO"
      },
      "source": [
        "A protein structure has a sequence associated. For example the following is the toxin sequence associated to the previous structure.\n"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "dc8eEvPrgOq0"
      },
      "outputs": [],
      "source": [
        "toxin_sequence = (\n",
        "    'LKCHNKLVPFLSKTCPEGKNLCYKMTLMKMPKIPIKRGCTDACPKSSLLVKVVCCNKDKCN'\n",
        ")"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "gFy4DCgIgQdS",
        "outputId": "7df49c81-71ef-4be5-eb37-c5fc4fb5e2fc"
      },
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "The length of the protein is 61.\n"
          ]
        }
      ],
      "source": [
        "print(f'The length of the protein is {len(toxin_sequence)}.')"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "Sg_1UA_rgS60"
      },
      "source": [
        "Now we have a **sequence representation** of a protein. But since machine learning deals with numerical data, how can we represent this sequence in a numerical form?"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "3e2miwtmgciP"
      },
      "source": [
        "## 2.1 One-hot encoding of a protein sequence."
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "gMSDFygmgiQg"
      },
      "source": [
        "The simplest way to represent a protein sequence is using a **one-hot encoding**. Here is how it works:\n",
        "- Since there are 21 possible amino acids, each amino acid must be one of these 21 options.\n",
        "- We can therefore represent each amino acid as a binary vector that is all zeroes except for a single \"1\" in the position corresponding to that amino acid.\n",
        "\n",
        "As a concrete example, imaginine we want to one-hot encode a small protein with just 5 amino acids, MALWN.\n",
        "\n",
        "First, let's define the mapping between an amino acid letter code to an integer index:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "mgo33x3wgka8",
        "outputId": "7c0fb32f-50ff-4983-f661-316e211ac8bd"
      },
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "{'R': 0,\n",
              " 'H': 1,\n",
              " 'K': 2,\n",
              " 'D': 3,\n",
              " 'E': 4,\n",
              " 'S': 5,\n",
              " 'T': 6,\n",
              " 'N': 7,\n",
              " 'Q': 8,\n",
              " 'G': 9,\n",
              " 'P': 10,\n",
              " 'C': 11,\n",
              " 'U': 12,\n",
              " 'A': 13,\n",
              " 'V': 14,\n",
              " 'I': 15,\n",
              " 'L': 16,\n",
              " 'M': 17,\n",
              " 'F': 18,\n",
              " 'Y': 19,\n",
              " 'W': 20}"
            ]
          },
          "metadata": {},
          "execution_count": 8
        }
      ],
      "source": [
        "amino_acids = [\n",
        "    'R', 'H','K', 'D', 'E',\n",
        "    'S', 'T', 'N', 'Q', 'G',\n",
        "    'P', 'C', 'U', 'A', 'V',\n",
        "    'I', 'L', 'M', 'F', 'Y',\n",
        "    'W']\n",
        "\n",
        "amino_acid_to_index = {\n",
        "    amino_acid: index for index, amino_acid in enumerate(amino_acids)\n",
        "    }\n",
        "\n",
        "amino_acid_to_index"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "XfM64hDvgmue"
      },
      "source": [
        "Now, given a specific protein sequence, or a small part of it that we call peptide o Kmer, we can convert it to a sequence of integers:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "wAbLzH_ff4j-",
        "outputId": "f5cdc585-8430-4df5-9173-3c6eaa7eccf3"
      },
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "[1, 7, 2, 16, 14, 10, 18, 16]"
            ]
          },
          "metadata": {},
          "execution_count": 9
        }
      ],
      "source": [
        "Toxin_Kmer = toxin_sequence[3:11]\n",
        "\n",
        "Toxin_Kmer_indices = [\n",
        "    amino_acid_to_index[amino_acid] for amino_acid in Toxin_Kmer]\n",
        "\n",
        "Toxin_Kmer_indices"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "7rfNESH1hUbX"
      },
      "source": [
        "In code, this is how we can get this embedding:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "lkhId-MqhWPd",
        "outputId": "2f651bb2-d777-4664-931a-df2fc008ebfb"
      },
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "tensor([[0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0],\n",
            "        [0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0],\n",
            "        [0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0],\n",
            "        [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0],\n",
            "        [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0],\n",
            "        [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0],\n",
            "        [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0],\n",
            "        [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0]])\n"
          ]
        }
      ],
      "source": [
        "# Convert indices list to a tensor\n",
        "indices_tensor = torch.tensor(Toxin_Kmer_indices)\n",
        "\n",
        "# Perform one-hot encoding\n",
        "one_hot_encoded_sequence = torch.nn.functional.one_hot(indices_tensor, num_classes=len(amino_acids))\n",
        "\n",
        "# Print the one-hot encoded sequence\n",
        "print(one_hot_encoded_sequence)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "th_lcIKSh-8B"
      },
      "source": [
        "So the encoding for the first amino acid \"M\" is:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "12qJxv3yh-YJ",
        "outputId": "9a2f1910-ced8-4f94-d73b-f07759d6b492"
      },
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "tensor([0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0])"
            ]
          },
          "metadata": {},
          "execution_count": 11
        }
      ],
      "source": [
        "one_hot_encoded_sequence[0]"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "iAoVF30NiC4U"
      },
      "source": [
        "We can visualise the one-hot encoded matrix representing our tiny protein sequence \"MALWN\":"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 269
        },
        "id": "fFo5QHrJiB6M",
        "outputId": "09cb9524-7246-414f-bebc-cb5366b85da4"
      },
      "outputs": [
        {
          "output_type": "display_data",
          "data": {
            "text/plain": [
              "<Figure size 640x480 with 1 Axes>"
            ],
            "image/png": 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\n"
          },
          "metadata": {}
        }
      ],
      "source": [
        "import seaborn as sns\n",
        "import matplotlib.pyplot as plt\n",
        "\n",
        "fig = sns.heatmap(\n",
        "    one_hot_encoded_sequence, square=True, cbar=False, cmap='viridis')\n",
        "fig.set(xlabel='amino acid index', ylabel='peptide sequence')\n",
        "plt.show()"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "sQyqq5bdiFzS"
      },
      "source": [
        "Having this basic numerical representation of a protein sequence allows us to interact with proteins mathematically. Although a good starting point, at the moment this representation is too basic to be useful. Let's now examine **dense learned embeddings of amino acids**."
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "9rGTMiU7iLJr"
      },
      "source": [
        "## 2.2 Learned embeddings of amino acids"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "O61llXz7iM7z"
      },
      "source": [
        "Thoughout the rest of the practical, we will use a popular pre-trained transformer protein language model called **ESM** from Meta. We will discuss more about how the model works in a minute, but first, let's explore its representation of amino acids."
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "bSUpfGTRiOOW"
      },
      "source": [
        " The model is hosted on the Hugging Face 🤗 platform. In case you are not already familiar with Hugging Face, it is a really fantastic resource of thousands of pre-trained models that you can quickly load and get started with. To access the ESM2 protein language model, we first will use the transformers library (ESM2 is a transformer-based model). Lets import the required module and load up the ESM2 tokenizer and model:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "O3dt8JC1iCBg"
      },
      "outputs": [],
      "source": [
        "from IPython.display import clear_output\n",
        "from transformers import AutoTokenizer, EsmModel, EsmConfig\n",
        "\n",
        "model_checkpoint = \"facebook/esm2_t30_150M_UR50D\"  # From: https://github.com/facebookresearch/esm#available-models-and-datasets-\n",
        "tokenizer = AutoTokenizer.from_pretrained(model_checkpoint)\n",
        "model = EsmModel.from_pretrained(model_checkpoint)\n",
        "clear_output()"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "1vSeJpvKiWHu"
      },
      "source": [
        "We can examine the mapping between tokens and indices that the ESM2 tokenizer uses:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "E6fzU6w-iCD-",
        "outputId": "1201baa8-f792-41be-b882-6517f62935cd"
      },
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "{'<cls>': 0,\n",
              " '<pad>': 1,\n",
              " '<eos>': 2,\n",
              " '<unk>': 3,\n",
              " 'L': 4,\n",
              " 'A': 5,\n",
              " 'G': 6,\n",
              " 'V': 7,\n",
              " 'S': 8,\n",
              " 'E': 9,\n",
              " 'R': 10,\n",
              " 'T': 11,\n",
              " 'I': 12,\n",
              " 'D': 13,\n",
              " 'P': 14,\n",
              " 'K': 15,\n",
              " 'Q': 16,\n",
              " 'N': 17,\n",
              " 'F': 18,\n",
              " 'Y': 19,\n",
              " 'M': 20,\n",
              " 'H': 21,\n",
              " 'W': 22,\n",
              " 'C': 23,\n",
              " 'X': 24,\n",
              " 'B': 25,\n",
              " 'U': 26,\n",
              " 'Z': 27,\n",
              " 'O': 28,\n",
              " '.': 29,\n",
              " '-': 30,\n",
              " '<null_1>': 31,\n",
              " '<mask>': 32}"
            ]
          },
          "metadata": {},
          "execution_count": 14
        }
      ],
      "source": [
        "vocab_to_index = tokenizer.get_vocab()\n",
        "vocab_to_index"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "S-v4P3IeiZNc"
      },
      "source": [
        "You can see it's quite similar to the amino acid to integer mapping we made manually, but contains some additional tokens that are useful such as a token for an unknown amino acid (`unk`) and a token designating the end of the string (`eos` for 'end of sentence').\n",
        "\n",
        "Let's use the tokenizer to encode our tiny protein sequence:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "JADGzCaqiCGp",
        "outputId": "0fc3cbe8-aa48-419b-d7ae-03204b0fc480"
      },
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "[0, 21, 17, 15, 4, 7, 14, 18, 4, 2]"
            ]
          },
          "metadata": {},
          "execution_count": 18
        }
      ],
      "source": [
        "tokenized_Toxin_Kmer = tokenizer(Toxin_Kmer)['input_ids']\n",
        "tokenized_Toxin_Kmer"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "dEOLkBP2ifb7"
      },
      "source": [
        "We could choose to chop off the initial `cls` and final `eos` tokens if we wanted to:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "xjh9y_8xic_C",
        "outputId": "9582eb21-8d2a-4434-8ee6-9132c00415fc"
      },
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "[21, 17, 15, 4, 7, 14, 18, 4]"
            ]
          },
          "metadata": {},
          "execution_count": 19
        }
      ],
      "source": [
        "tokenized_Toxin_Kmer[1:-1]"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "uHDcabDMnYmg"
      },
      "source": [
        "Let's extract the embeddings for each amino acid:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "VtAQ9R0WYMje",
        "outputId": "b4e91408-d2df-471b-86c9-285e79a358b9"
      },
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "(33, 640)"
            ]
          },
          "metadata": {},
          "execution_count": 20
        }
      ],
      "source": [
        "token_embeddings = model.get_input_embeddings().weight.detach().numpy()\n",
        "token_embeddings.shape"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "Vdo7wytDYvx2"
      },
      "source": [
        "You can see that for each of the 33 possible input tokens, we have a 640-dimensional embedding vector.\n",
        "\n",
        "Although it's a bit (!) tricky to visualise in 640 dimensions, we can use a dimensionality reduction technique such as tSNE to map this information down to 2 dimensions and plot where each token lies in this new 2 dimensional space:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "Xg2__L6rtho2",
        "outputId": "dd0650f7-644b-4e7c-b92c-1bf9125e9582"
      },
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "(33, 2)"
            ]
          },
          "metadata": {},
          "execution_count": 21
        }
      ],
      "source": [
        "from sklearn.manifold import TSNE\n",
        "\n",
        "tsne = TSNE(n_components=2, learning_rate='auto', init='random',\n",
        "            random_state=123, perplexity=3)\n",
        "embeddings_tsne = tsne.fit_transform(token_embeddings)\n",
        "embeddings_tsne_df = pd.DataFrame(\n",
        "    embeddings_tsne, columns=['first_dim', 'second_dim'])\n",
        "embeddings_tsne_df.shape"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "3Lob9MZPZbG6"
      },
      "source": [
        "Let's plot a scatter plot:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 468
        },
        "id": "qvYIjaTzZOvi",
        "outputId": "b3eefa3f-36f5-4a96-8f7f-94ce51a8e152"
      },
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "<Axes: xlabel='first_dim', ylabel='second_dim'>"
            ]
          },
          "metadata": {},
          "execution_count": 22
        },
        {
          "output_type": "display_data",
          "data": {
            "text/plain": [
              "<Figure size 640x480 with 1 Axes>"
            ],
            "image/png": 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\n"
          },
          "metadata": {}
        }
      ],
      "source": [
        "sns.scatterplot(data=embeddings_tsne_df,\n",
        "                x='first_dim',\n",
        "                y='second_dim',\n",
        "                s=50)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "0KE0NEM1ZLcH"
      },
      "source": [
        "To see if similar types of tokens and amino acids cluster together, we can label each token with its label, and replot the plot and colour by label:"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 363
        },
        "id": "4lr3pAU2tzWB",
        "outputId": "3d240eb6-530d-4582-b653-ea8911c7ad9c"
      },
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "    first_dim  second_dim  token               label\n",
              "0   84.252831 -151.931641  <cls>       special_token\n",
              "1 -328.320160   26.773651  <pad>       special_token\n",
              "2   98.762131 -182.481689  <eos>       special_token\n",
              "3 -354.844238   39.576466  <unk>       special_token\n",
              "4   49.348991  156.832977      L         hydrophobic\n",
              "5  -12.306890   88.708771      A         hydrophobic\n",
              "6  -90.414093   -0.246226      G  special_amino_acid\n",
              "7   11.655083  127.006844      V         hydrophobic\n",
              "8  -62.815372   33.480095      S     polar_uncharged\n",
              "9  239.446838   81.936119      E  negatively_charged"
            ],
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              "      <td>11.655083</td>\n",
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            ],
            "application/vnd.google.colaboratory.intrinsic+json": {
              "type": "dataframe",
              "variable_name": "embeddings_tsne_df",
              "summary": "{\n  \"name\": \"embeddings_tsne_df\",\n  \"rows\": 33,\n  \"fields\": [\n    {\n      \"column\": \"first_dim\",\n      \"properties\": {\n        \"dtype\": \"float32\",\n        \"num_unique_values\": 33,\n        \"samples\": [\n          45.8167724609375,\n          234.90904235839844,\n          -145.985595703125\n        ],\n        \"semantic_type\": \"\",\n        \"description\": \"\"\n      }\n    },\n    {\n      \"column\": \"second_dim\",\n      \"properties\": {\n        \"dtype\": \"float32\",\n        \"num_unique_values\": 33,\n        \"samples\": [\n          -65.9063491821289,\n          -89.0955581665039,\n          -246.07411193847656\n        ],\n        \"semantic_type\": \"\",\n        \"description\": \"\"\n      }\n    },\n    {\n      \"column\": \"token\",\n      \"properties\": {\n        \"dtype\": \"string\",\n        \"num_unique_values\": 33,\n        \"samples\": [\n          \"<null_1>\",\n          \"K\",\n          \"U\"\n        ],\n        \"semantic_type\": \"\",\n        \"description\": \"\"\n      }\n    },\n    {\n      \"column\": \"label\",\n      \"properties\": {\n        \"dtype\": \"category\",\n        \"num_unique_values\": 6,\n        \"samples\": [\n          \"special_token\",\n          \"hydrophobic\",\n          \"positively_charged\"\n        ],\n        \"semantic_type\": \"\",\n        \"description\": \"\"\n      }\n    }\n  ]\n}"
            }
          },
          "metadata": {},
          "execution_count": 23
        }
      ],
      "source": [
        "embeddings_tsne_df['token'] = list(vocab_to_index.keys())\n",
        "\n",
        "token_labels = {\n",
        "    '<cls>': 'special_token',\n",
        "    '<pad>': 'special_token',\n",
        "    '<eos>': 'special_token',\n",
        "    '<unk>': 'special_token',\n",
        "    'L': 'hydrophobic',\n",
        "    'A': 'hydrophobic',\n",
        "    'G': 'special_amino_acid',\n",
        "    'V': 'hydrophobic',\n",
        "    'S': 'polar_uncharged',\n",
        "    'E': 'negatively_charged',\n",
        "    'R': 'positively_charged',\n",
        "    'T': 'polar_uncharged',\n",
        "    'I': 'hydrophobic',\n",
        "    'D': 'negatively_charged',\n",
        "    'P': 'special_amino_acid',\n",
        "    'K': 'positively_charged',\n",
        "    'Q': 'polar_uncharged',\n",
        "    'N': 'polar_uncharged',\n",
        "    'F': 'hydrophobic',\n",
        "    'Y': 'hydrophobic',\n",
        "    'M': 'hydrophobic',\n",
        "    'H': 'positively_charged',\n",
        "    'W': 'hydrophobic',\n",
        "    'C': 'special_amino_acid',\n",
        "    'X': 'special_amino_acid',\n",
        "    'B': 'special_amino_acid',\n",
        "    'U': 'special_amino_acid',\n",
        "    'Z': 'special_amino_acid',\n",
        "    'O': 'special_amino_acid',\n",
        "    '.': 'special_token',\n",
        "    '-': 'special_token',\n",
        "    '<null_1>': 'special_token',\n",
        "    '<mask>': 'special_token'\n",
        "    }\n",
        "\n",
        "embeddings_tsne_df['label'] = embeddings_tsne_df['token'].map(token_labels)\n",
        "\n",
        "embeddings_tsne_df.head(10)"
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "ax = sns.scatterplot(data=embeddings_tsne_df,\n",
        "                x='first_dim',\n",
        "                y='second_dim',\n",
        "                hue='label',\n",
        "                s=50, alpha=0.7)\n",
        "plt.legend(loc='center left', bbox_to_anchor=(1, 0.5))\n",
        "\n",
        "plt.tight_layout()\n",
        "\n",
        "# Add the token name next to its position in the embedding space.\n",
        "for i, token in enumerate(embeddings_tsne_df['token']):\n",
        "  plt.annotate(text=token,\n",
        "               xy=(embeddings_tsne_df['first_dim'][i] + 15,\n",
        "                   embeddings_tsne_df['second_dim'][i] - 5),\n",
        "               alpha=0.6)"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 487
        },
        "id": "RVlRsGR4chRV",
        "outputId": "0f38a819-2ffe-4526-9406-6b36c687ca01"
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "display_data",
          "data": {
            "text/plain": [
              "<Figure size 640x480 with 1 Axes>"
            ],
            "image/png": 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\n"
          },
          "metadata": {}
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "gG2RcAq2jG6x"
      },
      "source": [
        "# 3. Using a protein language model\n",
        "The output of the ESM model is updated embeddings, with the same dimensions and sequence length as the input, with encoded information about the specific protein and each amino acid."
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "uX5drmvhjG6x",
        "outputId": "4a26d5fb-6fe1-4153-9c25-7998e37f58c7"
      },
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Protein sequence length: 61\n",
            "Model output shape: torch.Size([1, 63, 640])\n"
          ]
        }
      ],
      "source": [
        "output = model(**tokenizer(toxin_sequence, return_tensors='pt'))\n",
        "print(f'Protein sequence length: {len(toxin_sequence)}')\n",
        "print(f'Model output shape: {output.last_hidden_state.shape}')"
      ]
    },
    {
      "cell_type": "markdown",
      "source": [
        "The shapes of each dimension and meaning is:\n",
        "*   `1` - Batch Size\n",
        "*   `112` - `<cls>` + 61 amino acids + `<eos>`\n",
        "*   `640` - Embedding size of the model and matches the size of our input embeddings\n",
        "\n",
        "Notice that the output length will change based on the length of the protein sequence. Often, we want to make predictions about the entire proteins. We can summarize proteins of various lengths by averaging the embeddings along the sequence.\n",
        "\n",
        "As an example, we can visualize the average embeddings of proteins which either belong inside the cellular fluid (cytosolic) or are stuck in the membrane of the protein."
      ],
      "metadata": {
        "id": "cNJAH7l3DWf4"
      }
    },
    {
      "cell_type": "code",
      "source": [
        "cytosolic_sequences = [\n",
        " 'MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRRM',\n",
        " 'MAARALCMLGLVLALLSSSSAEEYVGLSANQCAVPAKDRVDCGYPHVTPKECNNRGCCFDSRIPGVPWCFKPLQEAECTF',\n",
        " 'MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ',\n",
        " 'MPLSDWCCGICEEAPLGRAYTQTWMETGCGPHGVTALGQQELKDCLRARSGGTASSVDWIMEAARGSLNVHNCLIKFGRRD',\n",
        " 'MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGGGGRKGRTKREAAANTNRPSPGGHERKLVTKLQNSERKKRGARR',\n",
        " 'MASSSGAGAAAAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEALSSVIKELRKATEALKAAENMTS',\n",
        " 'MAVFHDEVEIEDFQYDEDSETYFYPCPCGDNFSITKEDLENGEDVATCPSCSLIIKVIYDKDQFVCGETVPAPSANKELVKC',\n",
        " 'MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTGRFNGQFKTYAICGAIRRMGESDDSILRLAKADGIVSKNF',\n",
        " 'MSGPNGDLGMPVEAGAEGEEDGFGEAEYAAINSMLDQINSCLDHLEEKNDHLHARLQELLESNRQTRLEFQQQLGEAPSDASP',\n",
        " 'MALSVLRLALLLLAVTFAASLIPQFGLFSKYRTPNCSQYRLPGCPRHFNPVCGSDMSTYANECTLCMKIREGGHNIKIIRNGPC']\n",
        "\n",
        "membrane_sequences = [\n",
        " 'MGRAMVARLGLGLLLLALLLPTQIYSSETTTGTSSNSSQSTSNSGLAPNPTNATTKAAGGALQSTASLFVVSLSLLHLYS',\n",
        " 'MATPTQTPTKAPEEPDPFYYDYNTVQTVGMTLATILFLLGILIVISKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV',\n",
        " 'MKYPLMPLVNDLTFSFLVFWFCLPVGLLLLLIIWLRFLLSQDSEENDSSVCLDWEPWSKGPAEFCWKGTLHGQEKERPCW',\n",
        " 'MAYHGLTVPLIVMSVFWGFVGFLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP',\n",
        " 'MDGGQPIPSSLVPLGNESADSSMSLEQKMTFVFVILLFIFLGILIVRCFRILLDPYRSMPTSTWADGLEGLEKGQFDHALA',\n",
        " 'MSSTYCGNSSAKMSVNEVSAFSLTLEQKTGFAFVGILCIFLGLLIIRCFKILLDPYSSMPSSTWEDEVEEFDKGTFEYALA',\n",
        " 'MSATWTLSPEPLPPSTGPPVGAGLDAEQRTVFAFVLCLLVVLVLLMVRCVRILLDPYSRMPASSWTDHKEALERGQFDYALV',\n",
        " 'MAVSTEELEATVQEVLGRLKSHQFFQSTWDTVAFIVFLTFMGTVLLLLLLVVAHCCCCSSPGPRRESPRKERPKGVDNLALEP',\n",
        " 'MEALGSGHYVGGSIRSMAAAALSGLAVRLSRPQGTRGSYGAFCKTLTRTLLTFFDLAWRLRKNFFYFYILASVILNVHLQVYI',\n",
        " 'MDLSFMAAQLPMMGGAFMDSPNEDFSTEYSLFNSSANVHAAANGQGQPEDPPRSSNDAVLLWIAIIATLGNIVVVGVVYAFTF']"
      ],
      "metadata": {
        "id": "6bdEl6f2FpIP"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "markdown",
      "source": [
        "We'll extract the embeddings for each sequence and then average along the sequence length.\n",
        "\n",
        "**Group Task:** Write function to compute average embedding over the sequence."
      ],
      "metadata": {
        "id": "ZREhz9VoViZo"
      }
    },
    {
      "cell_type": "code",
      "source": [
        "def sequence_embeddings(sequences, device='cpu'):\n",
        "  model_inputs = tokenizer(sequences,padding=True, return_tensors='pt')\n",
        "  model_inputs = {k:v.to(device) for k,v in model_inputs.items()}\n",
        "  outputs = model(**model_inputs)\n",
        "  # TODO: Implement averaging. Should convert shape\n",
        "  # shape (<Batch>, <Sequence Length>, <Embedding>) -> (<Batch>, <Embedding>)\n"
      ],
      "metadata": {
        "id": "xeQKu3UlH7JW"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "# @title Answer to code task (Try not to peek until you've given it a good try!')\n",
        "\n",
        "def sequence_embeddings(sequences, device='cpu'):\n",
        "  model_inputs = tokenizer(sequences,padding=True, return_tensors='pt')\n",
        "  model_inputs = {k:v.to(device) for k,v in model_inputs.items()}\n",
        "  outputs = model(**model_inputs)\n",
        "  embeddings = outputs.last_hidden_state.detach().cpu().numpy()\n",
        "  seq_len = model_inputs['attention_mask'].cpu().sum(axis=-1, keepdims=True)\n",
        "  return np.sum(embeddings, axis=1) / seq_len  # Average along sequence dimension."
      ],
      "metadata": {
        "id": "qE-LvrswyGfV"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "markdown",
      "source": [
        "###### Now we'll compute this for the sequences."
      ],
      "metadata": {
        "id": "SAi_T9plyHfB"
      }
    },
    {
      "cell_type": "code",
      "source": [
        "cytosolic_embeddings = sequence_embeddings(cytosolic_sequences)\n",
        "membrane_embeddings = sequence_embeddings(membrane_sequences)\n",
        "combined_embeddings = np.concatenate([cytosolic_embeddings, membrane_embeddings], axis=0)"
      ],
      "metadata": {
        "id": "Z-zKD3S6IesY"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "combined_embeddings.shape"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "Y54TRB8zVq81",
        "outputId": "cf27e648-cd86-41f6-cecb-b58ac4ebcd93"
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "(20, 640)"
            ]
          },
          "metadata": {},
          "execution_count": 30
        }
      ]
    },
    {
      "cell_type": "markdown",
      "source": [
        "Notice that even though the lengths of the proteins are different, the averaged embeddings are all the same length.\n",
        "\n",
        "This makes it easy to then feed into downstream classifeirs that require a fixed feature length e.g. Random Forest or a simple Multilayer Perceptron."
      ],
      "metadata": {
        "id": "0LzYM7DPVvgD"
      }
    },
    {
      "cell_type": "code",
      "source": [
        "embeddings_tsne = TSNE(n_components=2, learning_rate='auto',\n",
        "                       init='random', random_state=123, perplexity=3).fit_transform(combined_embeddings)\n",
        "embeddings_tsne_df = pd.DataFrame(\n",
        "    embeddings_tsne, columns=['first_dim', 'second_dim'])\n",
        "embeddings_tsne_df['type'] = ['Cytosolic'] * len(cytosolic_sequences) + ['Membrane'] * len(membrane_sequences)"
      ],
      "metadata": {
        "id": "w7tgWzzlJmG0"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "ax = sns.scatterplot(data=embeddings_tsne_df,\n",
        "                x='first_dim',\n",
        "                y='second_dim',\n",
        "                hue='type',\n",
        "                s=50, alpha=0.7)\n",
        "plt.legend(loc='center left', bbox_to_anchor=(1, 0.5))\n",
        "plt.title('Plot of embeddings T-SNE Plot')\n",
        "plt.tight_layout()"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 487
        },
        "id": "QZ5-ZYhzvrYR",
        "outputId": "56a61858-5d0b-4c75-dca9-83f838f322b7"
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "display_data",
          "data": {
            "text/plain": [
              "<Figure size 640x480 with 1 Axes>"
            ],
            "image/png": 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\n"
          },
          "metadata": {}
        }
      ]
    },
    {
      "cell_type": "markdown",
      "source": [
        "As you can see, there is some nice clustering of the different protein types. This means that embeddings contain information on where the protein is located with-in the cell."
      ],
      "metadata": {
        "id": "zTLYU8ajVT7k"
      }
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "PzqX0xqs2elM"
      },
      "source": [
        "# 4. Training a model\n",
        "\n",
        "Last year we used a dataset [to train a simple model using the amino acid embeddings](https://github.com/deep-learning-indaba/indaba-pracs-2023/blob/main/practicals/ML_for_Bio_Indaba_Practical_2023.ipynb) to predict Snake Antivenom Binding.\n",
        "\n",
        "<!-- !['Paths to Follow'](https://assets.stickpng.com/images/580b57fbd9996e24bc43bce5.png) -->\n",
        "<img src=\"https://assets.stickpng.com/images/580b57fbd9996e24bc43bce5.png\"  width=\"60%\">\n",
        "\n",
        "\n",
        "\n",
        "Currently, the only effective treatment against snakebite envenoming consists of unspecified cocktails of polyclonal antibodies. These antivenom antibodies work unreliably across different species of snake, and until recently little data existed on which of the 2000+ snake venom toxins they bind, as well as where the binding of the antibody to the toxin occurs.\n",
        "\n",
        "To address this issue, a recent study used high-density peptide microarray (HDPM) technology with all currently available African snake toxin protein sequences, together with eight commercial antivenoms in clinical use in Africa to better understand how antivenoms bind to specific snake venom toxins.\n",
        "\n",
        "We will use the dataset from this study, which measures how cross-reactive the eight snake antivenoms are and where in the toxin sequence the antibodies they bind to the toxin (epitope).\n",
        "\n",
        "!['Paths to Follow'](https://i.ibb.co/sgtcN4v/ml-for-bio-02-720.png)\n",
        "\n",
        "\n",
        "\n",
        "The specific dataset we will use originates from the [African Snake Antivenom Binding Challenge](https://zindi.africa/competitions/umojahack-africa-2022-advanced-challenge) hosted on [Zindi](https://zindi.africa/).\n",
        "\n",
        "This year we will deep dive on how this dataset has been created!\n",
        "Welcome to the wold of mass spectrometry and peptide sequencing!"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "1qZZ4T_H2ele"
      },
      "source": [
        "## 5.1 Loading the data\n",
        "\n"
      ]
    },
    {
      "cell_type": "markdown",
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        "id": "deQI0Op-lHzw"
      },
      "source": [
        "Reading in the data with Pandas"
      ]
    },
    {
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        "id": "ll9ABaS02ele",
        "outputId": "04d49d7c-ec0d-4ebd-c929-15abf425487c"
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          "data": {
            "text/plain": [
              "                  ID Toxin_UniprotID  Kmer_Position_start  Kmer_Position_end  \\\n",
              "0  P07037_Bioclone_1          P07037                    1                 16   \n",
              "1  P07037_Bioclone_2          P07037                    2                 17   \n",
              "2  P07037_Bioclone_3          P07037                    3                 18   \n",
              "3  P07037_Bioclone_4          P07037                    4                 19   \n",
              "4  P07037_Bioclone_5          P07037                    5                 20   \n",
              "\n",
              "  Antivenom        Toxin_Kmer  Signal       Genus              Species  \\\n",
              "0  Bioclone  NLYQFKNMIQCTVPNR   -0.53  Aspidelaps  Aspidelaps_scutatus   \n",
              "1  Bioclone  LYQFKNMIQCTVPNRS   -1.00  Aspidelaps  Aspidelaps_scutatus   \n",
              "2  Bioclone  YQFKNMIQCTVPNRSW   -0.21  Aspidelaps  Aspidelaps_scutatus   \n",
              "3  Bioclone  QFKNMIQCTVPNRSWW   -0.30  Aspidelaps  Aspidelaps_scutatus   \n",
              "4  Bioclone  FKNMIQCTVPNRSWWH   -1.00  Aspidelaps  Aspidelaps_scutatus   \n",
              "\n",
              "         ProteinFam      ProteinSubFam   ProteinSubSubFam  \n",
              "0  Phospholipase_A2  Group_I_subfamily  D49_sub_subfamily  \n",
              "1  Phospholipase_A2  Group_I_subfamily  D49_sub_subfamily  \n",
              "2  Phospholipase_A2  Group_I_subfamily  D49_sub_subfamily  \n",
              "3  Phospholipase_A2  Group_I_subfamily  D49_sub_subfamily  \n",
              "4  Phospholipase_A2  Group_I_subfamily  D49_sub_subfamily  "
            ],
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              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>P07037_Bioclone_3</td>\n",
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              "      <td>3</td>\n",
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              "      <td>Bioclone</td>\n",
              "      <td>YQFKNMIQCTVPNRSW</td>\n",
              "      <td>-0.21</td>\n",
              "      <td>Aspidelaps</td>\n",
              "      <td>Aspidelaps_scutatus</td>\n",
              "      <td>Phospholipase_A2</td>\n",
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              "      <th>3</th>\n",
              "      <td>P07037_Bioclone_4</td>\n",
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              "      <td>P07037</td>\n",
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              "      <td>-1.00</td>\n",
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              "\n",
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            ],
            "application/vnd.google.colaboratory.intrinsic+json": {
              "type": "dataframe",
              "variable_name": "data_df"
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          },
          "metadata": {},
          "execution_count": 33
        }
      ],
      "source": [
        "data_df = pd.read_csv(\"https://storage.googleapis.com/umojahack2022/train.csv\")\n",
        "data_df.head(5)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "YWv8eIUH2ele"
      },
      "source": [
        "Each row in the dataset represents a k-mer (16 amino acid sequence within the toxin) and it has a signal column coming from the high-density peptide microarray experiment. With this, we will predict signal column generated by a given `Toxin_K_mer` and `Antivenom`.\n",
        "\n",
        "Note: A K-mer is a subsequence of a full protein consisting of `K` sequential amino acids"
      ]
    },
    {
      "cell_type": "markdown",
      "source": [
        "# 5. Further Resources"
      ],
      "metadata": {
        "id": "t_Kd79bK_JyK"
      }
    },
    {
      "cell_type": "markdown",
      "source": [
        "We hope that this practical has got you excited about applying machine learning to biology!\n",
        "\n",
        "If you'd like to venture a little deeper down this rabbit hole, here are some of the resources we found useful in preparing this practical:\n",
        "1. [I should have loved biology ](https://jsomers.net/i-should-have-loved-biology/) (Essay by James Somers)\n",
        "2. [The Most Complex Language in the World](https://www.youtube.com/watch?v=TYPFenJQciw) (Youtube video by Kurzgesagt)\n",
        "3. [Language models of protein sequences at the scale\n",
        "of evolution enable accurate structure prediction](https://www.biorxiv.org/content/10.1101/2022.07.20.500902v1.full.pdf) (ESM paper)\n",
        "4. [Inner Life of a Cell | Protein Packing Animation](https://www.youtube.com/watch?v=uHeTQLNFTgU) (Protein packing animation)\n",
        "\n",
        "Today we have focussed on proteins, but the field of biology is enormous and there is plently of other areas ripe for research! From drug discovery, modelling genes to studying the brain! Best of luck for your journey ahead 🚀"
      ],
      "metadata": {
        "id": "zM3mSQsD_MJV"
      }
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "oglV4kHMWnIN"
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      "source": [
        "<img src=\"https://baobab.deeplearningindaba.com/static/media/indaba-logo-dark.d5a6196d.png\" width=\"50%\" />"
      ]
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