sPY_template

/*--------------------------------------------------------------
	TEMPLATE FILE FOR REGULAR-SPIKING CORTICAL PYRAMIDAL CELL
	---------------------------------------------------------

	One compartment model and currents derived from:

   Pospischil, M., Toledo-Rodriguez, M., Monier, C., Piwkowska, Z., 
   Bal, T., Fregnac, Y., Markram, H. and Destexhe, A.
   Minimal Hodgkin-Huxley type models for different classes of
   cortical and thalamic neurons.
   Biological Cybernetics 99: 427-441, 2008.

	This model was inspired from:

   McCormick, D.A., Wang, Z. and Huguenard, J. Neurotransmitter 
   control of neocortical neuronal activity and excitability. 
   Cerebral Cortex 3: 387-398, 1993.

	- one compartment model
	- passive
	- HH: Traub
	- IM: m format

	Alain Destexhe, CNRS, 2008

--------------------------------------------------------------*/


print " "
print " << defining template for one-compartment sPY cell >> "
print " "


begintemplate sPY		// create a new template object
public soma

create soma[1]

proc init() { local v_potassium, v_sodium

  v_potassium = -100		// potassium reversal potential 
  v_sodium = 50			// sodium reversal potential 

  soma {
	Ra = 100		// geometry 
	nseg = 1
	diam = 96
	L = 96			// so that area is about 29000 um2
	cm = 1

	insert pas		// leak current 
	e_pas = -70
	g_pas = 0.0001		// Rin = 34 Meg

	// conversion with McC units: 
	// g(S/cm2) = g(nS)*1e-9/29000e-8
	//	    = g(nS) * 3.45e-6

	insert hh2		// Hodgin-Huxley INa and IK 
	ek = v_potassium
	ena = v_sodium
	vtraub_hh2 = -55	// Resting Vm, BJ was -55
	gnabar_hh2 = 0.05	// McCormick=15 muS, thal was 0.09
	gkbar_hh2 = 0.005	// spike duration of pyr cells


	insert im		// M current 
	taumax_im = 1000
	gkbar_im = 7e-5		// Diego's IM (copyrighted)

//	insert iahp
//	alpha_iahp = 1.25e9
//	beta_iahp = 0.001
//	gkbar_iahp = 1.7e-5	// McCormick=5 nS

//	insert cad		// calcium decay
//	depth_cad = 1		// McCormick= 0.1 um
//	taur_cad = 5		// McCormick=1 ms !!!
//	cainf_cad = 2.4e-4	// McCormick=0
//	kt_cad = 0		// no pump
  }

  print " "
  print "<< sPY: passive, INa, IK, IM inserted >>"
  print " "

}
endtemplate sPY