cortical_stimulation.hoc

//----------------------------------------------------------------------------
access str_soma
objectvar stim2,upbkgrnd,dwnbkgrnd // insert NetStim in MSN neuron Changed 3/28/2012 KMB From stim1
 

//create "artificial cell" stimulation
//***********************************************************************************

proc cor_stim() { 
		


objref stim2,upbkgrnd,dwnbkgrnd


		//To excite in the upstate Amplitude does not make the difference frequecy does
		// the upstate peak is ~800 Hz with max upstate lasting ~300ms Blackwell et al 2003
		// to keep the cell in up state the input must be at least 450 hz for no more than 300ms
		// This is the Glutamate connection i.e. NMDA AMPA stimulation
		
		stim2 = new KBNetStim(0.5) //3/28/2012 KMB Changed to add functionality to NetStim
		stim2.interval = 2	// therefore interval should be ~3.333msec
		// With upstate background at 2 ms interval (500 hz) this should cause excitation
		stim2.number = 0
		stim2.noise = 0
		stim2.start = 1
		

		//interval therefore should not chage only number if the upstate bckground noise 
		//is 500Hz to cause firing it should increase up to ~800 therefor add 300Hz input
		
		//This is an upstate background it is 
		
		// Therefore 150 pulses with interval of 2.0 ms= 300 ms w/ f=500 Hz

		
		upbkgrnd = new KBNetStim(0.5) //3/28/2012 KMB Changed to add functionality to NetStim
		upbkgrnd.interval = 2.5		
		upbkgrnd.number = 13			//(msec)interval*number = time
		upbkgrnd.noise = 0
		upbkgrnd.start = 1
		
		dwnbkgrnd = new KBNetStim(0.5) //3/28/2012 KMB Changed to add functionality to NetStim
		
		
		// for down state ~ 300 seems to be accurate 
		
		dwnbkgrnd.interval =25		 // for down state ~10-40Hz this is 100ms to 25ms 
		dwnbkgrnd.number =0			// (msec) interval*number = time
		dwnbkgrnd.noise =0		
		dwnbkgrnd.start =1
		
		
}