Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

Sign up for GitHub

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Jump to bottom

"Extend" of Initial conditions: Introduce container criteria for molecules #2355

Open
Tracked by #2130
rwmcintosh opened this issue Oct 30, 2024 · 1 comment
Open
Tracked by #2130

"Extend" of Initial conditions: Introduce container criteria for molecules #2355

rwmcintosh opened this issue Oct 30, 2024 · 1 comment
Labels
prio: high type: feature
Milestone
OSMOSES vNext

Comments

@rwmcintosh
Copy link
Member

No description provided.

@rwmcintosh rwmcintosh mentioned this issue Oct 30, 2024
Closed
4 tasks
@rwmcintosh rwmcintosh added this to v12 Oct 30, 2024
@PavelBal PavelBal self-assigned this Nov 4, 2024
@PavelBal
Copy link
Member

PavelBal commented Nov 5, 2024

Okay, so what we need is some kind of Container criteria for molecules that are respected when extending the IC BB.

  • \<Molecule>-FcRn_Complex are present in Plasma, Interstitial, Endosome and "Not in container: BloodOrgan"
  • FcRn only in Plasma, Interstitial, Endosome and "In Container: EndogenousIgG"
  • LigandEndo only "In container: EndogenousIgG"
  • LigandEndo_Complex only in Plasma, Interstitial, Endosome and "In Container: EndogenousIgG"

This would also solve #2356

@PavelBal PavelBal mentioned this issue Nov 5, 2024
Closed
@PavelBal PavelBal removed their assignment Nov 5, 2024
@PavelBal PavelBal added this to the OSMOSES vNext milestone Nov 6, 2024
@PavelBal PavelBal removed this from v12 Nov 6, 2024
@PavelBal PavelBal changed the title "Extend" of Initial conditions: by default, do not extend for FcRn-complexes (e.g. "Fluvoxamine-FcRn_Complex") (== use PK-Sim knowledge). This should be managed by a check box (e.g. "Do not create for FcRn blabla..") "Extend" of Initial conditions: Introduce container criteria for molecules Nov 22, 2024
@PavelBal PavelBal mentioned this issue Dec 17, 2024
Closed
@github-project-automation github-project-automation bot moved this to Under discussion (technically feasible; open for sponsorship) in OSP Suite Software Roadmap Jan 2, 2025
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Assignees
No one assigned
Labels
prio: high type: feature
Projects
OSP Suite Software Roadmap
Status: Under discussion (technically feasible; open for sponsorship)
Milestone
OSMOSES vNext
Development

No branches or pull requests
3 participants
@rwmcintosh @Yuri05 @PavelBal