diff --git a/.gitattributes b/.gitattributes new file mode 100644 index 00000000..fb70f761 --- /dev/null +++ b/.gitattributes @@ -0,0 +1,5 @@ +* text=auto +*.m text diff=matlab +.gitattributes export-ignore +.gitignore export-ignore +.github export-ignore \ No newline at end of file diff --git a/.gitignore b/.gitignore index 840b4722..37e56fad 100644 --- a/.gitignore +++ b/.gitignore @@ -46,6 +46,12 @@ Thumbs.db *.mat helpsearch*/ +# Python-related things # +######################### +*.ipynb_checkpoints/ +*.pyc +*.env + # Non-complying tables # ######################## *.xls diff --git a/ComplementaryData/databases/BiGGmetDictionary.csv b/ComplementaryData/databases/BiGGmetDictionary.csv new file mode 100644 index 00000000..0b6fe794 --- /dev/null +++ b/ComplementaryData/databases/BiGGmetDictionary.csv @@ -0,0 +1,1722 @@ +s_0001[ce],13BDglcn +s_0002[c],13BDglcn +s_0003[e],13BDglcn +s_0004[ce],16BDglcn +s_0006[m],2ahhmd +s_0007[c],aconm +s_0008[m],23dhmp +s_0009[c],3c2hmp 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+s_3527[ce],pa160161 +s_3529[ce],pa180161 +s_3530[ce],pa181161 +s_3531[ce],pa160181 +s_3532[ce],pa161181 +s_3533[ce],pa180181 +s_3534[ce],pa181181 +s_3535[ce],pail3p160161 +s_3538[ce],pail3p180161 +s_3539[ce],pail3p181161 +s_3540[ce],pail3p160181 +s_3541[ce],pail3p161181 +s_3542[ce],pail3p180181 +s_3543[ce],pail3p181181 +s_3544[c],pail3p160161 +s_3545[c],pail160161 +s_3548[c],pail3p180161 +s_3549[c],pail180161 +s_3550[c],pail3p181161 +s_3551[c],pail181161 +s_3552[c],pail3p160181 +s_3553[c],pail160181 +s_3554[c],pail3p161181 +s_3555[c],pail161181 +s_3556[c],pail3p180181 +s_3557[c],pail180181 +s_3558[c],pail3p181181 +s_3559[c],pail181181 +s_3560[erm],pail3p160161 +s_3562[erm],pail3p180161 +s_3563[erm],pail3p181161 +s_3564[erm],pail3p160181 +s_3565[erm],pail3p161181 +s_3566[erm],pail3p180181 +s_3567[erm],pail3p181181 +s_3568[gm],pail3p160161 +s_3570[gm],pail3p180161 +s_3571[gm],pail3p181161 +s_3572[gm],pail3p160181 +s_3573[gm],pail3p161181 +s_3574[gm],pail3p180181 +s_3575[gm],pail3p181181 +s_3576[c],pail4p160161 +s_3578[c],pail4p180161 +s_3579[c],pail4p181161 +s_3580[c],pail4p160181 +s_3581[c],pail4p161181 +s_3582[c],pail4p180181 +s_3583[c],pail4p181181 +s_3584[erm],pail4p160161 +s_3586[erm],pail4p180161 +s_3587[erm],pail4p181161 +s_3588[erm],pail4p160181 +s_3589[erm],pail4p161181 +s_3590[erm],pail4p180181 +s_3591[erm],pail4p181181 +s_3592[ce],pail35bp160161 +s_3593[ce],pail35bp161161 +s_3594[ce],pail35bp180161 +s_3595[ce],pail35bp181161 +s_3596[ce],pail35bp160181 +s_3597[ce],pail35bp161181 +s_3598[ce],pail35bp180181 +s_3599[ce],pail35bp181181 +s_3600[c],pail35bp160161 +s_3601[c],pail35bp161161 +s_3602[c],pail35bp180161 +s_3603[c],pail35bp181161 +s_3604[c],pail35bp160181 +s_3605[c],pail35bp161181 +s_3606[c],pail35bp180181 +s_3607[c],pail35bp181181 +s_3608[erm],pail45bp160161 +s_3609[erm],pail45bp161161 +s_3610[erm],pail45bp180161 +s_3611[erm],pail45bp181161 +s_3612[erm],pail45bp160181 +s_3613[erm],pail45bp161181 +s_3614[erm],pail45bp180181 +s_3615[erm],pail45bp181181 +s_3616[vm],dag2p160161 +s_3617[vm],dag2p161161 +s_3618[vm],dag2p180161 +s_3619[vm],dag2p181161 +s_3620[vm],dag2p160181 +s_3621[vm],dag2p161181 +s_3622[vm],dag2p180181 +s_3623[vm],dag2p181181 +s_3624[gm],dag2p160161 +s_3625[gm],dag2p161161 +s_3626[gm],dag2p180161 +s_3627[gm],dag2p181161 +s_3628[gm],dag2p160181 +s_3629[gm],dag2p161181 +s_3630[gm],dag2p180181 +s_3631[gm],dag2p181181 +s_3634[c],1acsngl3ph161 +s_3635[c],mag161 +s_3638[c],1acsngl3ph181 +s_3642[vm],1acsngl3ph161 +s_3643[vm],mag161 +s_3646[vm],1acsngl3ph181 +s_3650[gm],1acsngl3ph161 +s_3651[gm],mag161 +s_3654[gm],1acsngl3ph181 +s_3656[lp],ergpal +s_3658[lp],ergole +s_3659[lp],epipal +s_3661[lp],epiole +s_3662[lp],fecpal +s_3663[lp],fecole +s_3664[lp],lanpal +s_3666[lp],lanole +s_3667[lp],zympal +s_3668[lp],zymole +s_3669[ce],zympal +s_3670[ce],zymole +s_3672[lp],mag161 +s_3675[m],dag160181 +s_3678[m],dag161181 +s_3679[m],mag161 +s_3680[m],dag180181 +s_3686[lp],pe160181 +s_3688[lp],pe161181 +s_3690[lp],pe180181 +s_3692[lp],pe181181 +s_3693[lp],pc160161 +s_3697[lp],pc180161 +s_3699[lp],pc181161 +s_3701[lp],pc160181 +s_3702[lp],pc161181 +s_3703[lp],pc180181 +s_3704[lp],pc181181 +s_3705[lp],pe160161 +s_3707[lp],pe180161 +s_3708[lp],pe181161 +s_3709[erm],ergstest +s_3718[c],carbohydrate +s_3721[g],cer +s_3722[c],cer +s_3723[c],mip2c +s_3724[c],ipc +s_3725[c],mipc +s_3726[er],lcb +s_3727[c],lcb +s_3728[er],lcbp +s_3729[c],lcbp +s_3730[erm],pa +s_3731[c],pa +s_3732[erm],dag +s_3733[c],dag +s_3734[erm],lpi +s_3735[c],lpi +s_3736[mm],pg +s_3737[c],pg +s_3738[mm],cl +s_3739[c],cl +s_3740[c],c160chain +s_3741[c],c161chain +s_3742[c],c180chain +s_3743[c],c181chain +s_3744[c],c240chain +s_3745[c],c260chain +s_3746[c],lipidbackbone +s_3747[c],lipidchain +s_3760[c],adpdrib1pho +s_3762[c],qui +s_3763[c],14ben +s_3767[er],nnchi +s_3768[c],drib5pho +s_3771[er],g0017 +s_3773[er],g0001 +s_3774[er],g00011 +s_3784[m],sulcarh +s_3786[m],sulcarsh +s_3789[c],3chlalc +s_3790[c],3chl +s_3791[c],3hydbenalc +s_3792[c],3hydben +s_3795[c],4isoalc +s_3796[c],pcumald +s_3806[c],4hyd4met2oxoglu +s_3807[c],lmetssoxi +s_3816[c],cytcllys +s_3817[c],cytcn6metllys +s_3819[n],llyshis +s_3821[n],n6metllyshis +s_3828[c],sben +s_3829[c],benz +s_3830[er],rx +s_3832[er],hx +s_3833[er],rsglu +s_3834[c],rx +s_3835[c],hx +s_3836[c],rsglu +s_3841[c],thr3hydlasp +s_3842[p],rx +s_3844[p],hx +s_3845[p],rsglu +s_3851[c],cya +s_3852[c],alddrib5pho +s_3853[c],rscys +s_3854[c],ssublcys +s_3856[c],glytrnala +s_3857[c],dtyrtrntyr +s_3858[c],dtyr +s_3863[m],3hyd2metcoa +s_3865[e],ste +s_3866[c],ste +s_3869[c],monaciami +s_3870[c],car +s_3873[c],ben +s_3876[c],proctersfarlcys +s_3877[c],prctesfalcymees +s_3879[er],g0014 +s_3884[c],prot +s_3885[c],largpro +s_3886[er],proasp +s_3887[er],g00008 +s_3888[er],doldip +s_3889[er],g00009 +s_3891[er],g106 +s_3893[er],g01 +s_3894[er],g00 +s_3895[er],g000 +s_3896[er],g0000 +s_3900[v],alpdmann +s_3901[v],alpdman +s_3902[v],nonglysugacc +s_3903[c],lthr +s_3909[c],suldon +s_3910[c],adp5eth4met2car +s_3911[er],dolbetdglupho +s_3912[er],g10599 +s_3917[c],apo +s_3918[c],pron6liplys +s_3923[c],n4oxoglulcys +s_3924[m],n4oxoglulcys +s_3927[c],rib5tri +s_3928[c],rib5pho +s_3929[c],2deo5tri +s_3930[c],2deo5pho +s_3932[er],g00012 +s_3934[c],eth +s_3940[c],pepdiph +s_3941[c],pepdip +s_3942[p],8oxodgt +s_3943[p],8oxodgm +s_3944[m],apo +s_3945[m],pron6octlys +s_3947[m],pron6liplys +s_3951[c],Glc_aD +s_3959[c],2pro +s_3960[c],pro +s_3975[c],tra3chlald +s_3976[c],tra3chlaci +s_3977[c],cis3chlald +s_3978[c],cis3chlaci +s_3979[c],chl +s_3980[c],chlaci +s_3983[c],2tra6trafar +s_3984[c],faraci +s_3985[erm],pho +s_3986[gm],pho +s_3988[c],1olesngly +s_3989[er],g10 +s_3990[er],g00006 +s_3993[er],g105 +s_3994[er],g1059 +s_3995[er],g10597 +s_3996[er],g00007 +s_4001[er],g10598 +s_4002[er],g00149 +s_4003[er],g001 +s_4004[m],suldon +s_4006[m],ssullcysdes +s_4007[m],disfor +s_4008[m],ssucydedifoscprco +s_4018[c],pol +s_4022[m],por +s_4023[c],por +s_4024[c],sta +s_4028[m],rx +s_4029[m],hx +s_4030[m],rsglu +s_4033[c],pron6acellys +s_4044[c],thy3mon +s_4045[e],thy3mon +s_4046[c],thy5mon +s_4047[e],thy5mon +s_4066[c],gua2mon +s_4067[e],gua2mon +s_4072[c],cysspho +s_4075[e],cysspho +s_4076[c],hyp +s_4081[c],uri2pho +s_4082[e],uri2pho +s_4088[c],npho +s_4090[e],npho +s_4100[c],cyt2pho +s_4101[e],cyt2pho +s_4131[e],tur +s_4136[c],3oxa3 +s_4137[e],3oxa3 +s_4187[c],2aceaci +s_4205[c],cofactor +s_4206[c],ion diff --git a/ComplementaryData/databases/BiGGrxnDictionary.csv b/ComplementaryData/databases/BiGGrxnDictionary.csv new file mode 100644 index 00000000..e4df652b --- /dev/null +++ b/ComplementaryData/databases/BiGGrxnDictionary.csv @@ -0,0 +1,1400 @@ +r_0001,D_LACDcm +r_0002,D_LACDm +r_0003,BTDD_RR +r_0004,L_LACD2cm +r_0007,PRMICI +r_0012,P5CDm +r_0014,DRTPPD +r_0016,ACHBSm +r_0018,AATA +r_0019,DPR +r_0020,DDPAm +r_0021,2HPMBQMTm +r_0022,2HP6MPMOm +r_0023,IPPMIb +r_0024,IPPS +r_0025,IPPSm +r_0028,MCITSm +r_0029,OMCDC +r_0030,OMCDCm +r_0032,BPNT +r_0033,PDE1 +r_0034,PDE2 +r_0035,PDE3 +r_0036,PDE4 +r_0037,PDE5 +r_0038,DB4PS +r_0039,DHQTi +r_0040,DHQS +r_0042,DDPA +r_0043,3OPHB5Hm +r_0045,HKYNH +r_0057,HACD6p +r_0058,3HAO +r_0060,IPPMIa +r_0061,IPMD +r_0062,3MOBDC +r_0063,MTMOHT +r_0064,3MOPDC +r_0065,PSCVT +r_0066,ADCS +r_0067,ADCL +r_0068,ABTA +r_0069,4HTHRS +r_0070,4HBZFm +r_0072,4MOPDC +r_0075,MTAP +r_0076,NTD4 +r_0077,NTD11 +r_0078,NTD2 +r_0079,PRFGS +r_0080,MTHFR3 +r_0081,ALASm +r_0084,FTHFCL +r_0085,MHPGLUT +r_0086,MDRPD +r_0087,MTRI +r_0090,PFK26 +r_0091,PGL +r_0095,ACALDCD +r_0099,ACOATAm +r_0100,ACACT8p +r_0101,ACACT9p +r_0102,ACACT7p +r_0103,ACACT1r +r_0104,ACACT1m +r_0105,ACACT6p +r_0106,ACACT4p +r_0108,ACCOACrm +r_0109,ACCOAC +r_0111,ACOAHim +r_0112,ACS +r_0113,ACSm +r_0115,ACGKm +r_0116,ACP1e +r_0117,ACONT3m +r_0118,ACOTAim +r_0119,ACPSm +r_0121,ACOAO5p +r_0122,ACOAO9p +r_0123,ACOAO7p +r_0124,ACOAO8p +r_0125,ACOAO6p +r_0138,ADD +r_0139,ADPT +r_0140,ADA +r_0142,ADNK1 +r_0143,AMPDA +r_0144,AHCi +r_0145,ADMDC +r_0146,AMAOTr +r_0147,ADNCYC +r_0148,ADK1 +r_0149,ADK1m +r_0150,ADK3m +r_0151,ADSL2r +r_0152,ADSL1r +r_0153,ADSS +r_0154,ADSK +r_0155,23CAPPD +r_0156,AGTi +r_0157,ALATRS +r_0158,OHACT3 +r_0160,OHACT2 +r_0161,OHACT4 +r_0162,OHACT5 +r_0163,ALCD2x +r_0164,ALCD19y +r_0165,ALCD2irm +r_0166,ALCD22xi +r_0167,ALCD22xim +r_0168,ALCD22yi +r_0169,ALCD25xi +r_0170,ALCD25xim +r_0171,ALCD25yi +r_0172,ALDD22x +r_0173,ALDD2y +r_0174,ALDD2xm +r_0175,ALDD2ym +r_0176,ALDD20xm +r_0177,ALDD20y +r_0178,ALDD20ym +r_0179,ALCD24xi +r_0180,ALCD24xim +r_0181,ALCD24yi +r_0182,ALCD23xi +r_0183,ALCD23xim +r_0184,ALCD23yi +r_0185,ALDD19xr +r_0186,ALCD26xi +r_0187,ALCD26xim +r_0188,AKP1 +r_0189,ALLTAHr +r_0190,ALLTN +r_0191,ALPHNH +r_0193,TREHv +r_0194,TREH +r_0195,TRE6PS +r_0198,MALT +r_0199,AMID +r_0200,AACTOOR +r_0201,ABUTDm +r_0202,ANPRT +r_0203,ANS +r_0204,AP4AH +r_0205,ARABR +r_0206,ARGN +r_0207,ARGSL +r_0208,ARGSS +r_0209,ARGTRS +r_0210,ARGTRSm +r_0211,ASNS1 +r_0212,ASNTRS +r_0213,ASNTRSm +r_0214,ASPCT +r_0215,ASPK 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+r_4553,EX_Lcyst_e +r_4554,EX_isetac_e +r_4555,EX_acac_e +r_4556,EX_acglu_e +r_4557,EX_ump_e +r_4558,EX_cmp_e +r_4563,EX_3ump_e +r_4564,EX_23ccmp_e +r_4565,EX_23cump_e +r_4573,MMSAD3 +r_4579,ACLS +r_4580,KARA1 +r_4581,ERTHMMOR +r_4583,FACOAE1829Z12Z +r_4584,FACOAL1821 +r_4585,STACHGALACT +r_4588,Clt +r_4590,MNt2 +r_4591,r2073_1 +r_4593,EX_cl_e +r_4594,EX_cu2_e +r_4595,EX_mn2_e +r_4596,EX_zn2_e +r_4597,EX_mg2_e +r_4600,EX_ca2_e diff --git a/ComplementaryData/databases/BiGGrxnDictionary_newIDs.csv b/ComplementaryData/databases/BiGGrxnDictionary_newIDs.csv new file mode 100644 index 00000000..49d4ca9c --- /dev/null +++ b/ComplementaryData/databases/BiGGrxnDictionary_newIDs.csv @@ -0,0 +1,2561 @@ +r_0005,13BETGLUSYN +r_0006,16BETGLUSYN +r_0013,23DI5ME1PHDERE +r_0015,DRPPPNRED25645 +r_0017,AHHM246 +r_0026,ARAT +r_0027,2METDEH +r_0041,3DSPHRr +r_0044,3HPH5MBDCm +r_0059,3ISO3MET +r_0073,4PPIP5DEPTOIP6 +r_0074,4PPIP5PYR45PP2IP4 +r_0082,PMI12346PH +r_0083,PMI12346PS +r_0088,5PPIP5PYR45PP2IP4 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+r_1803,GDPMANNtg +r_1827,Htlp +r_1831,Htv +r_1833,HEXCCOAtr +r_1834,EX_hxdcal_e +r_1837,HIS__Ltm +r_1851,IPC124tgr +r_1852,IPC224tgr +r_1853,IPC2A24tgr +r_1854,IPC324tgr +r_1855,IPC424tgr +r_1856,IPC126tgr +r_1857,IPC226tgr +r_1858,IPC2A26tgr +r_1859,IPC326tgr +r_1860,IPC426tgr +r_1890,GLU__Ltn +r_1892,GLN__Ltn +r_1907,SER__Ltr +r_1919,LYS__Ltm +r_1920,MIP2C124tgr +r_1921,MIP2C224tgr +r_1922,MIP2C2A24tgr +r_1923,MIP2C324tgr +r_1924,MIP2C424tgr +r_1925,MIP2C126tgr +r_1926,MIP2C226tgr +r_1927,MIP2C2A26tgr +r_1928,MIP2C326tgr +r_1929,MIP2C426tgr +r_1937,MIPC124tgr +r_1938,MIPC224tgr +r_1939,MIPC2A24tgr +r_1940,MIPC324tgr +r_1941,MIPC424tgr +r_1942,MIPC126tgr +r_1943,MIPC226tgr +r_1944,MIPC2A26tgr +r_1945,MIPC326tgr +r_1946,MIPC426tgr +r_1952,EX_nndif_e +r_1966,NCAMtn +r_1971,NMNtx +r_2004,PHE__Ltm +r_2008,PItv +r_2063,TTCCOAtr +r_2080,TREtv +r_2082,TRP__Ltm +r_2087,TYR__Ltx +r_2107,ZYMSTtce +r_2108,BIOMASS_yeastGEM_LIP +r_2111,GROWTH +r_2125,COAtlp +r_2134,EX_44mzym_e +r_2136,44MZYMt +r_2137,EX_ergtetrol_e +r_2139,ERGTETROLt +r_2229,BUTtx +r_2231,OCDCEAtx +r_2812,LATR160161mm +r_2813,LATR160181mm +r_2814,LPCAT161161_sn2mm +r_2815,LATR161181mm +r_2816,LATR180161mm +r_2817,LATR180181mm +r_2818,LATR181161mm +r_2819,LATR181181mm +r_3332,KIN160161gm +r_3333,KIN161161gm +r_3334,KIN180161gm +r_3335,KIN181161gm +r_3336,KIN160181gm +r_3337,KIN161181gm +r_3338,KIN180181gm +r_3339,KIN181181gm +r_3340,KIN160161vm +r_3341,KIN161161vm +r_3342,KIN180161vm +r_3343,KIN181161vm +r_3344,KIN160181vm +r_3345,KIN161181vm +r_3346,KIN180181vm +r_3347,KIN181181vm +r_3508,DDCAtrm +r_3509,TTDCAtrm +r_3510,HDCAtrm +r_3511,HDCEAtrm +r_3512,OCDCAtrm +r_3513,OCDCEAtrm +r_3514,MALCOAtrm +r_3515,DDCACOAtrm +r_3516,TDCOAtrm +r_3517,PMTCOAtrm +r_3518,HDCOAtrm +r_3519,STCOAtrm +r_3520,OCDCE9COAtrm +r_3521,ARACHCOAtrm +r_3522,DOCOSCOAtrm +r_3523,TTCCOAtrm +r_3524,HEXCCOAtrm +r_3525,Htrm +r_3526,H2Otrm +r_3527,CO2trm +r_3528,COAtrm +r_3529,NADPHtrm +r_3530,NADPtrm +r_3531,O2trm +r_3532,NADHtrm +r_3533,NADtrm +r_3534,GLYC3Ptrm +r_3535,DHAPtrm +r_3536,PPItrm +r_3537,PItrm +r_3538,CTPtrm +r_3539,CDPtrm +r_3540,CMPtrm +r_3541,CDPEAtrm +r_3542,CDPCHOLtrm +r_3543,ATPtrm +r_3544,AMPtrm +r_3545,SER__Ltrm +r_3546,INOSTtrm +r_3547,AMETtrm +r_3548,AHCYStrm +r_3549,EPISTtrm +r_3550,FECOSTtrm +r_3551,LANOSTtrm +r_3552,ERGSTtrm +r_3553,ZYMSTtrm +r_3554,DAG160161trm +r_3555,12DGR161trm +r_3556,DAG180161trm +r_3557,DAG181161trm +r_3558,DAG160181trm +r_3559,DAG161181trm +r_3560,DAG180181trm +r_3561,12DGR181trm +r_3562,PAIL160161trm +r_3563,PAIL161trm +r_3564,PAIL180161trm +r_3565,PAIL181161trm +r_3566,PAIL160181trm +r_3567,PAIL161181trm +r_3568,PAIL180181trm +r_3569,PAIL181181trm +r_3570,G3PCtrm +r_3571,HDCAtlp +r_3572,HDCEAtlp +r_3573,OCDCAtlp +r_3574,OCDCEAtlp +r_3575,DDCACOAtlp +r_3576,TDCOAtlp +r_3577,PMTCOAtlp +r_3578,HDCOAtlp +r_3579,STCOAtlp +r_3580,OCDCE9COAtlp +r_3581,GLYC3Ptlp +r_3582,DHAPtlp +r_3583,NADPHtlp +r_3584,NADPtlp +r_3585,ATPtlp +r_3586,AMPtlp +r_3587,PPItlp +r_3588,DAG160161tlp +r_3589,12DGR161tlp +r_3590,DAG180161tlp +r_3591,DAG181161tlp +r_3592,DAG160181tlp +r_3593,DAG161181tlp +r_3594,DAG180181tlp +r_3595,12DGR181tlp +r_3596,H2Otlp +r_3597,GLYCtlp +r_3598,DOCOSCOAtlp +r_3599,TTCCOAtlp +r_3600,HEXCCOAtlp +r_3601,ATPtce +r_3602,ADPtce +r_3603,Htce +r_3604,H2Otce +r_3605,PItce +r_3606,G3PCtce +r_3607,G3PItce +r_3608,HDCAtce +r_3609,HDCEAtce +r_3610,OCDCAtce +r_3611,OCDCEAtce +r_3612,ARACHCOAtce +r_3613,DOCOSCOAtce +r_3614,TTCCOAtce +r_3615,HEXCCOAtce +r_3616,PAIL45BP160161tce +r_3617,PAIL45BP161161tce +r_3618,PAIL45BP180161tce +r_3619,PAIL45BP181161tce +r_3620,PAIL45BP160181tce +r_3621,PAIL45BP161181tce +r_3622,PAIL45BP180181tce +r_3623,PAIL45BP181181tce +r_3624,PAIL4P160161tce +r_3625,PAIL4P161tce +r_3626,PAIL4P180161tce +r_3627,PAIL4P181161tce +r_3628,PAIL4P160181tce +r_3629,PAIL4P161181tce +r_3630,PAIL4P180181tce +r_3631,PAIL4P181181tce +r_3632,PAIL45BP160161tn +r_3633,PAIL45BP161161tn +r_3634,PAIL45BP180161tn +r_3635,PAIL45BP181161tn +r_3636,PAIL45BP160181tn +r_3637,PAIL45BP161181tn +r_3638,PAIL45BP180181tn +r_3639,PAIL45BP181181tn +r_3640,DAG160161tn +r_3641,12DGR161tn +r_3642,DAG180161tn +r_3643,DAG181161tn +r_3644,DAG160181tn +r_3645,DAG161181tn +r_3646,DAG180181tn +r_3647,12DGR181tn +r_3648,H2Otvm +r_3649,PItvm +r_3650,Htvm +r_3651,ATPtvm +r_3652,ADPtvm +r_3653,CO2tvm +r_3654,PAIL35BP160161tvm +r_3655,PAIL35BP161161tvm +r_3656,PAIL35BP180161tvm +r_3657,PAIL35BP181161tvm +r_3658,PAIL35BP160181tvm +r_3659,PAIL35BP161181tvm +r_3660,PAIL35BP180181tvm +r_3661,PAIL35BP181181tvm +r_3662,H2Otgm +r_3663,PItgm +r_3664,Htgm +r_3665,CO2tgm +r_3666,ATPtgm +r_3667,ADPtgm +r_3668,H2Otmm +r_3669,CO2tmm +r_3670,HDCOAtmm +r_3671,OCDCE9COAtmm +r_3672,DAG160161tmm +r_3673,12DGR161tmm +r_3674,DAG180161tmm +r_3675,DAG181161tmm +r_3676,DAG160181tmm +r_3677,DAG161181tmm +r_3678,HDCAtmm +r_3679,OCDCAtmm +r_3680,COAtmm +r_3681,DDCAtrmlp +r_3682,TTDCAtrmlp +r_3683,LGNCtrmlp +r_3684,HEXCtrmlp +r_3685,TAG160161160trmlp +r_3686,TAG160161161trmlp +r_3687,TAG160161180trmlp +r_3688,TAG160161181trmlp +r_3689,TAG1619Z1619Z160trmlp +r_3690,TAG1619Z1619Z1619Ztrmlp +r_3691,TAG161161180trmlp +r_3692,TAG1619Z1619Z1819Ztrmlp +r_3693,TAG180161160trmlp +r_3694,TAG180161161trmlp +r_3695,TAG180161180trmlp +r_3696,TAG180161181trmlp +r_3697,TAG181161160trmlp +r_3698,TAG1819Z1619Z1619Ztrmlp +r_3699,TAG181161180trmlp +r_3700,TAG1819Z1619Z1819Ztrmlp +r_3701,TAG160181160trmlp +r_3702,TAG160181161trmlp +r_3703,TAG160181180trmlp +r_3704,TAG160181181trmlp +r_3705,TAG161181160trmlp +r_3706,TAG161181161trmlp +r_3707,TAG161181180trmlp +r_3708,TAG161181181trmlp +r_3709,TAG180181160trmlp +r_3710,TAG180181161trmlp +r_3711,TAG180181180trmlp +r_3712,TAG180181181trmlp +r_3713,TAG181181160trmlp +r_3714,TAG181181161trmlp +r_3715,TAG181181180trmlp +r_3716,TAG181181181trmlp +r_3717,EPISTtrmlp +r_3718,FECOSTtrmlp +r_3719,LANOSTtrmlp +r_3720,ZYMSTtrmlp +r_3721,ERGPALtrmlp +r_3722,ERGOLEtrmlp +r_3723,EPIPALtrmlp +r_3724,EPIOLEtrmlp +r_3725,FECPALtrmlp +r_3726,FECOLEtrmlp +r_3727,LANPALtrmlp +r_3728,LANOLEtrmlp +r_3729,ZYMPALtrmlp +r_3730,ZYMOLEtrmlp +r_3731,PC160161trmlp +r_3732,PC161trmlp +r_3733,PC180161trmlp +r_3734,PC181161trmlp +r_3735,PC160181trmlp +r_3736,PC161181trmlp +r_3737,PC180181trmlp +r_3738,PC181181trmlp +r_3739,PE160161trmlp +r_3740,PE161trmlp +r_3741,PE180161trmlp +r_3742,PE181161trmlp +r_3743,PE160181trmlp +r_3744,PE161181trmlp +r_3745,PE180181trmlp +r_3746,PE181181trmlp +r_3747,1AGPC160trmlp +r_3748,1AGPC161trmlp +r_3749,1AGPC180trmlp +r_3750,1AGPC181trmlp +r_3751,1AGPE160trmlp +r_3752,1AGPE161trmlp +r_3753,1AGPE180trmlp +r_3754,1AGPE181trmlp +r_3755,PA160181tlprm +r_3756,PA161181tlprm +r_3757,PA180181tlprm +r_3758,PA181181tlprm +r_3759,PA160161trmmm +r_3760,PA161trmmm +r_3761,PA180161trmmm +r_3762,PA181161trmmm +r_3763,PA160181trmmm +r_3764,PA161181trmmm +r_3765,PS160161trmmm +r_3766,PS161161trmmm +r_3767,PS180161trmmm +r_3768,PS181161trmmm +r_3769,PS160181trmmm +r_3770,PS161181trmmm +r_3771,PS180181trmmm +r_3772,PS181181trmmm +r_3773,PE160161tmmrm +r_3774,PE161tmmrm +r_3775,PE180161tmmrm +r_3776,PE181161tmmrm +r_3777,PE160181tmmrm +r_3778,PE161181tmmrm +r_3779,PE180181tmmrm +r_3780,PE181181tmmrm +r_3781,PC160161trmmm +r_3782,PC161trmmm +r_3783,PC180161trmmm +r_3784,PC181161trmmm +r_3785,PC160181trmmm +r_3786,PC161181trmmm +r_3787,PC180181trmmm +r_3788,PC181181trmmm +r_3789,DAG160161trmgm +r_3790,12DGR161trmgm +r_3791,DAG180161trmgm +r_3792,DAG181161trmgm +r_3793,DAG160181trmgm +r_3794,DAG161181trmgm +r_3795,DAG180181trmgm +r_3796,12DGR181trmgm +r_3797,PA160161trmgm +r_3798,PA161trmgm +r_3799,PA180161trmgm +r_3800,PA181161trmgm +r_3801,PA160181trmgm +r_3802,PA161181trmgm +r_3803,PA180181trmgm +r_3804,PA181181trmgm +r_3805,PAIL160161trmgm +r_3806,PAIL161trmgm +r_3807,PAIL180161trmgm +r_3808,PAIL181161trmgm +r_3809,PAIL160181trmgm +r_3810,PAIL161181trmgm +r_3811,PAIL180181trmgm +r_3812,PAIL181181trmgm +r_3813,PS160161trmgm +r_3814,PS161161trmgm +r_3815,PS180161trmgm +r_3816,PS181161trmgm +r_3817,PS160181trmgm +r_3818,PS161181trmgm +r_3819,PS180181trmgm +r_3820,PS181181trmgm +r_3821,PE160161tgmrm +r_3822,PE161tgmrm +r_3823,PE180161tgmrm +r_3824,PE181161tgmrm +r_3825,PE160181tgmrm +r_3826,PE161181tgmrm +r_3827,PE180181tgmrm +r_3828,PE181181tgmrm +r_3829,PA160161trmvm +r_3830,PA161trmvm +r_3831,PA180161trmvm +r_3832,PA181161trmvm +r_3833,PA160181trmvm +r_3834,PA161181trmvm +r_3835,PA180181trmvm +r_3836,PA181181trmvm +r_3837,PAIL160161trmvm +r_3838,PAIL161trmvm +r_3839,PAIL180161trmvm +r_3840,PAIL181161trmvm +r_3841,PAIL160181trmvm +r_3842,PAIL161181trmvm +r_3843,PAIL180181trmvm +r_3844,PAIL181181trmvm +r_3845,PS160161trmvm +r_3846,PS161161trmvm +r_3847,PS180161trmvm +r_3848,PS181161trmvm +r_3849,PS160181trmvm +r_3850,PS161181trmvm +r_3851,PS180181trmvm +r_3852,PS181181trmvm +r_3853,PE160161tvmrm +r_3854,PE161tvmrm +r_3855,PE180161tvmrm +r_3856,PE181161tvmrm +r_3857,PE160181tvmrm +r_3858,PE161181tvmrm +r_3859,PE180181tvmrm +r_3860,PE181181tvmrm +r_3861,PAIL3P160161tvmrm +r_3862,PAIL3P161tvmrm +r_3863,PAIL3P180161tvmrm +r_3864,PAIL3P181161tvmrm +r_3865,PAIL3P160181tvmrm +r_3866,PAIL3P161181tvmrm +r_3867,PAIL3P180181tvmrm +r_3868,PAIL3P181181tvmrm +r_3869,PAIL160161trmce +r_3870,PAIL161trmce +r_3871,PAIL180161trmce +r_3872,PAIL181161trmce +r_3873,PAIL160181trmce +r_3874,PAIL161181trmce +r_3875,PAIL180181trmce +r_3876,PAIL181181trmce +r_3877,PC160161trmce +r_3878,PC161trmce +r_3879,PC180161trmce +r_3880,PC181161trmce +r_3881,PC160181trmce +r_3882,PC161181trmce +r_3883,PC180181trmce +r_3884,PC181181trmce +r_3885,PE160161trmce +r_3886,PE161trmce +r_3887,PE180161trmce +r_3888,PE181161trmce +r_3889,PE160181trmce +r_3890,PE161181trmce +r_3891,PE180181trmce +r_3892,PE181181trmce +r_3893,PS160161trmce +r_3894,PS161161trmce +r_3895,PS180161trmce +r_3896,PS181161trmce +r_3897,PS160181trmce +r_3898,PS161181trmce +r_3899,PS180181trmce +r_3900,PS181181trmce +r_3901,LGNCtcerm +r_3902,HEXCtcerm +r_3903,PA160161tcerm +r_3904,PA161tcerm +r_3905,PA180161tcerm +r_3906,PA181161tcerm +r_3907,PA160181tcerm +r_3908,PA161181tcerm +r_3909,PA180181tcerm +r_3910,PA181181tcerm +r_3911,PAIL4P160161tcerm +r_3912,PAIL4P161tcerm +r_3913,PAIL4P180161tcerm +r_3914,PAIL4P181161tcerm +r_3915,PAIL4P160181tcerm +r_3916,PAIL4P161181tcerm +r_3917,PAIL4P180181tcerm +r_3918,PAIL4P181181tcerm +r_3919,PAIL45BP160161tcerm +r_3920,PAIL45BP161161tcerm +r_3921,PAIL45BP180161tcerm +r_3922,PAIL45BP181161tcerm +r_3923,PAIL45BP160181tcerm +r_3924,PAIL45BP161181tcerm +r_3925,PAIL45BP180181tcerm +r_3926,PAIL45BP181181tcerm +r_3927,ZYMPALtrmce +r_3928,ZYMOLEtrmce +r_3929,PAIL160161trmn +r_3930,PAIL161trmn +r_3931,PAIL180161trmn +r_3932,PAIL181161trmn +r_3933,PAIL160181trmn +r_3934,PAIL161181trmn +r_3935,PAIL180181trmn +r_3936,PAIL181181trmn +r_3937,LGNCtrmr +r_3938,HEXCtrmr +r_3939,ERGSTtrrm +r_3940,PItrrm +r_3941,PAIL3P160161tvmgm +r_3942,PAIL3P161tvmgm +r_3943,PAIL3P180161tvmgm +r_3944,PAIL3P181161tvmgm +r_3945,PAIL3P160181tvmgm +r_3946,PAIL3P161181tvmgm +r_3947,PAIL3P180181tvmgm +r_3948,PAIL3P181181tvmgm +r_3949,PAIL35BP160161tvmce +r_3950,PAIL35BP161161tvmce +r_3951,PAIL35BP180161tvmce +r_3952,PAIL35BP181161tvmce +r_3953,PAIL35BP160181tvmce +r_3954,PAIL35BP161181tvmce +r_3955,PAIL35BP180181tvmce +r_3956,PAIL35BP181181tvmce +r_3957,Htmmm +r_3958,GLYC3Ptmmm +r_3959,CMPtmmm +r_3960,CTPtmmm +r_3961,PItmmm +r_3962,PPItmmm +r_3973,ERGSTESTtrm +r_3987,PS_CHOtrm +r_3996,PCHOL_CHOtrm +r_4005,PE_HStrm +r_4038,TAG_CHOtrm +r_4040,HEMEAtm +r_4041,BIOMASS_yeastGEM +r_4047,BIOMASS_yeastGEM_PROT +r_4048,BIOMASS_yeastGEM_CARB +r_4049,BIOMASS_yeastGEM_RNA +r_4050,BIOMASS_yeastGEM_DNA +r_4051,CERtg +r_4052,MIP2Ctg +r_4053,IPCtg +r_4054,MIPCtg +r_4055,LCBtr +r_4056,LCBPtr +r_4057,PAtrm +r_4058,DAGtrm +r_4059,LPItrm +r_4060,PGtmm +r_4061,CLtmm +r_4062,SINK_LIPBACK +r_4063,BIOMASS_yeastGEM_LIPBACK +r_4064,SINK_LIPCHAIN +r_4065,BIOMASS_yeastGEM_LIPCHAIN +r_4066,cer1_24SLIMEg +r_4067,cer1_26SLIMEg +r_4068,cer2_24SLIMEg +r_4069,cer2_26SLIMEg +r_4070,cer2a24SLIMEg +r_4071,cer2a26SLIMEg +r_4072,cer3_24SLIMEg +r_4073,cer3_26SLIMEg +r_4074,cer424SLIMEg +r_4075,cer426SLIMEg +r_4076,psphingsSLIMEer +r_4077,psph1pSLIMEer +r_4078,sphgnSLIMEer +r_4079,sph1pSLIMEer +r_4080,pa160161SLIMErm +r_4081,pa160181SLIMErm +r_4082,pa161SLIMErm +r_4083,pa161181SLIMErm +r_4084,pa180161SLIMErm +r_4085,pa180181SLIMErm +r_4086,pa181161SLIMErm +r_4087,pa181181SLIMErm +r_4088,dag160161SLIMErm +r_4089,dag160181SLIMErm +r_4090,12dgr161SLIMErm +r_4091,dag161181SLIMErm +r_4092,dag180161SLIMErm +r_4093,dag180181SLIMErm +r_4094,dag181161SLIMErm +r_4095,12dgr181SLIMErm +r_4096,lpi161SLIMErm +r_4097,lpi181SLIMErm +r_4098,pg160161SLIMEmm +r_4099,pg161161SLIMEmm +r_4100,pg180161SLIMEmm +r_4101,pg181161SLIMEmm +r_4102,pg160181SLIMEmm +r_4103,pg161181SLIMEmm +r_4104,cl160161160161SLIMEmm +r_4105,cl160161161161SLIMEmm +r_4106,cl160161180161SLIMEmm +r_4107,cl160161181161SLIMEmm +r_4108,cl160161160181SLIMEmm +r_4109,cl160161161181SLIMEmm +r_4110,cl161161160161SLIMEmm +r_4111,clpn161SLIMEmm +r_4112,cl161161180161SLIMEmm +r_4113,cl161161181161SLIMEmm +r_4114,cl161161160181SLIMEmm +r_4115,cl161161161181SLIMEmm +r_4116,cl180161160161SLIMEmm +r_4117,cl180161161161SLIMEmm +r_4118,cl180161180161SLIMEmm +r_4119,cl180161181161SLIMEmm +r_4120,cl180161160181SLIMEmm +r_4121,cl180161161181SLIMEmm +r_4122,cl181161160161SLIMEmm +r_4123,cl181161161161SLIMEmm +r_4124,cl181161180161SLIMEmm +r_4125,cl181161181161SLIMEmm +r_4126,cl181161160181SLIMEmm +r_4127,cl181161161181SLIMEmm +r_4128,cl160181160161SLIMEmm +r_4129,cl160181161161SLIMEmm +r_4130,cl160181180161SLIMEmm +r_4131,cl160181181161SLIMEmm +r_4132,cl160181160181SLIMEmm +r_4133,cl160181161181SLIMEmm +r_4134,cl161181160161SLIMEmm +r_4135,cl161181161161SLIMEmm +r_4136,cl161181180161SLIMEmm +r_4137,cl161181181161SLIMEmm +r_4138,cl161181160181SLIMEmm +r_4139,cl161181161181SLIMEmm +r_4140,cl181181160161SLIMEmm +r_4141,cl181181161161SLIMEmm +r_4142,cl181181180161SLIMEmm +r_4143,cl181181181161SLIMEmm +r_4144,cl181181160181SLIMEmm +r_4145,cl181181161181SLIMEmm +r_4146,cl160161181181SLIMEmm +r_4147,cl161161181181SLIMEmm +r_4148,cl180161181181SLIMEmm +r_4149,cl181161181181SLIMEmm +r_4150,cl160181181181SLIMEmm +r_4151,cl161181181181SLIMEmm +r_4154,ACTDn +r_4155,AGGGAFMSTYOXI +r_4156,MAMEMEAPE2 +r_4157,APPPRRPHT1 +r_4158,NADOXI +r_4159,GLCNACTr +r_4160,ADADADDIRIPPT +r_4161,ARG__Ltv +r_4162,HIS__Ltv +r_4163,LYS__Ltv +r_4164,OXACOALx +r_4165,ARALPSGCL2 +r_4166,ARALPSGCL22 +r_4167,VACACHCO1VAHOCCFAPR1 +r_4168,FRUtv +r_4169,GALtv +r_4170,GLCNACPTr +r_4173,LCYSACCSUL +r_4174,CHSTEROLtrrm +r_4175,PUARALDHG +r_4176,PUARALDHG2 +r_4178,PUARALDHG3 +r_4181,MANTRAATP1 +r_4184,HMOGPPFLYA442 +r_4186,LMETDISSOXI +r_4187,PROTRSm +r_4189,4AHYDTETHYDHYDLYA +r_4192,CYLYMET1 +r_4193,ADMELYMET +r_4194,ZN2tr +r_4195,ZN2tmv +r_4196,FCYTOB5OXRr +r_4198,BIBCFPRRED24 +r_4199,GLGS1 +r_4200,GLGS12 +r_4201,GLGS13 +r_4203,ILLLVYAPE1 +r_4204,ILLLVYAPE12 +r_4206,THHYASAMLYA3 +r_4207,EGDDLMOP24 +r_4209,GTHDHx +r_4210,UREHYDLYACYAFOR +r_4211,RPGPPPGHLYA535 +r_4215,CGDUGPGDCSMDP1 +r_4217,FEROm +r_4218,ADGTATTDCL +r_4219,ADGTATTDCL2 +r_4220,4NITPHOPHO +r_4223,3HYD2METCOAHYD +r_4225,BRRAACPHDE3.DEERPR1t +r_4229,MONACIAMIAMI +r_4231,ACYAMI +r_4233,ADMETEFACYMET +r_4234,GGGPCS +r_4237,CAVATRATP2 +r_4238,CATRATP2g +r_4239,LARGTRNARGPROARG +r_4240,DOOLDIPRSU +r_4241,MAPROLGCL +r_4242,ISAOCEPMAT161 +r_4243,AADGGMADGLPMAT1236 +r_4244,GMMAMBGBGDAMAT1314146 +r_4245,MANPGHv +r_4246,ALMA +r_4247,ATPTHRBICADE +r_4250,DOLDIPPHO +r_4251,CTPCYT +r_4252,THITHISYNTHIBIOENZ +r_4253,DBGPGAGAMAMAMAMAMAMAMAMAMBGBGDA13131212131213121616141412 +r_4256,LIPATPT +r_4258,LCPLAF +r_4260,DEDGGLHO1 +r_4261,DEDGGLHO12 +r_4263,CLtg +r_4264,FRD2m +r_4265,NUCTRIDIP +r_4269,HINNNCPPSST1 +r_4271,EMAMOR129 +r_4272,ALMAAL12 +r_4273,ETH2OXINITFOR +r_4275,FEIINADOXI +r_4276,FEIINADOXI2 +r_4277,ACGPATR31 +r_4278,DIPLIGAMPFOR +r_4279,8OXODGTDIP +r_4280,OCANACPROC +r_4281,LIPACPPRON6LIP +r_4283,HEX7 +r_4295,2PRO1ALNOXI +r_4297,TMABADH +r_4298,ALDHc +r_4299,IMACTD +r_4301,5HOXINDACTOX +r_4303,FATALDDEHHFD +r_4304,FATALDDEHHFD +r_4305,CHLOXI +r_4306,PYLALDOX +r_4307,FAROXI +r_4308,AAPPPPT +r_4309,PUTESTYMR +r_4310,GDMAALMAT12 +r_4311,GDMAALMAT122 +r_4312,SADELMETNMET +r_4313,AADGMAGLPMAT12689 +r_4314,AADGMAGLPMAT126892 +r_4316,ADDEGMADGLMPMAT11223967 +r_4318,ISO6ALPDGLU +r_4319,DEX6ALPDGLU +r_4320,DBGPMAMAMAMAMAMAMAMAMBGBGDA1212131213121616141413 +r_4321,DBGPGAMAMAMAMAMAMAMAMAMBGBGDA131212131213121616141413 +r_4322,GPMAT4 +r_4323,PRON6OCTANOLYSSUL +r_4324,OCTANOACPSULSUL +r_4325,IRSUCLASPR2MIIRSUCLSCPR2 +r_4327,MG2tm +r_4328,UDPPHOBETDGLU +r_4331,ACBEGL14 +r_4333,POLPHO +r_4334,CU2abc_c_g +r_4337,IROSULCLUTRAATMMIT +r_4338,ALOLGCL126 +r_4339,UACGAMtrg +r_4340,DHAAAOP3 +r_4341,GLYC2Pt +r_4343,THRPHOPROSYMt +r_4344,PTHRc +r_4345,ALKPHO +r_4346,GUATRAPROSYM +r_4351,ALKPHO2 +r_4352,CYSSPHOt +r_4353,CYSOXI +r_4354,HYPOXI +r_4356,2AMIYRATRA +r_4357,ALKPHO3 +r_4358,URPRPHPRSY2t +r_4361,GLYMETTRAPROSYM +r_4362,DIP +r_4363,R07 +r_4364,NPHOTRA +r_4365,CRETRA +r_4368,TYRPc +r_4369,TRITRAINPROSYM +r_4370,ALKPHO4 +r_4371,CYPRMOPRSY2t +r_4372,CYCPHO +r_4373,PRPRCYUMPRSY23t +r_4374,SUALCALYA34 +r_4375,SULALAPROANT3t +r_4377,3AMPt +r_4378,ALPGLU +r_4380,RE2223c +r_4381,ACETRAPROSYM +r_4382,THICOXI +r_4383,TETt +r_4385,5DGLCNt2ec +r_4386,DIP2 +r_4387,ALAASPPROSYMt +r_4388,CYCPHO2 +r_4389,PRPRCYCMPRSY23t +r_4390,BG_MADGc +r_4392,ALPMETGLUPROSYMt +r_4393,ATPTAG6PHO +r_4394,DTAG6PHO4EPI +r_4398,ALAGLNTRAPROSYM +r_4399,LALALGLUtcv +r_4401,ALATHRTRAPROSYM +r_4402,ALTHPRSYEXCYt +r_4403,PPA2 +r_4404,GLASPRSYEXCYt +r_4405,GLYC1Pt +r_4408,LALALGLUtec +r_4409,LALGPv +r_4410,3OXAGLYLYAOXAFOR +r_4411,LCYSBISLYADEA +r_4412,CYCPHO3 +r_4413,DEO3PRIPHO +r_4414,CYTNONDIP +r_4415,CYTNONSPEDIP +r_4416,CYTNONSPEDIP2 +r_4417,CYTNONSPEDIP3 +r_4418,CYTNONSPEDIP4 +r_4419,LCYSTRAPROSYM +r_4420,ALPGLU2 +r_4421,2HYDTRAPROSYM +r_4422,3OXATRAPROSYM +r_4423,GLYMETTRAPROSYM2 +r_4424,GLYGLNTRAPROSYM +r_4425,GLYGLNTRAPROSYM2 +r_4426,ALAGLNTRAPROSYM2 +r_4427,NACETRAPROSYM +r_4428,PHOTRAPROSYM +r_4429,ALAHISTRAPROSYM +r_4430,ALAHISTRAPROSYM2 +r_4431,ALAASPPROSYMt +r_4433,THY3MONt +r_4434,THY5MONt +r_4435,GLY1PHOPHO +r_4436,NSTPMPHT5 +r_4437,GLGLPRSYEXCYt +r_4438,GLGLPRSYCYVAt +r_4439,CYTNONDIP2 +r_4440,MET__Ltv +r_4441,THR__Ltv +r_4443,23CGMPt +r_4446,G1Pt +r_4447,CBPt +r_4448,MEALPRSYEXCYt +r_4449,MEALPRSYCYVAt +r_4452,MINOHPt +r_4453,G6Pt +r_4454,UMPt +r_4456,MAN6Pt +r_4457,PHOETHPROSYMt +r_4460,PYRTRAINPROSYM +r_4464,23CAMPt +r_4465,ADPRMOPRSY2t +r_4471,ALLEPRSYEXCYt +r_4472,ALLEPRSYCYVAt +r_4473,LALATRAPROANT +r_4474,LALATRAPROANT2 +r_4478,METSOX_S__Lt +r_4479,GLYASNTRAPROSYM +r_4480,CYSTRAPROANT +r_4481,H2SO +r_4482,ALAt2cv +r_4483,GLYt2cv +r_4491,ARAREDDARA +r_4493,ACACt +r_4495,ALKPHO5 +r_4497,EX_3oxa3_e +r_4501,EX_tur_e +r_4509,EX_ala_L_ile__L_e +r_4522,EX_glyc1p_e +r_4528,EX_pppi_e +r_4531,EX_cbp_e +r_4533,EX_cysspho_e +r_4534,EX_gua2mon_e +r_4544,EX_amp2p_e +r_4551,EX_3sala_e +r_4559,EX_thy5mon_e +r_4560,EX_thy3mon_e +r_4561,EX_cyt2pho_e +r_4562,EX_uri2pho_e +r_4566,GNK +r_4567,6PHOPHO +r_4568,R06 +r_4569,CARESTHYD +r_4570,PHODEH +r_4571,SEE +r_4572,APAT2c +r_4574,3OXOOXIDECCOAACE +r_4575,3OXOPROCARLYA +r_4576,KARI_23dhmbc +r_4577,DIHACIDEHMIT +r_4578,KETACIREDMIT +r_4582,MALBETMETSYN +r_4586,STASYN +r_4587,CA2t3ec +r_4589,CU2TRA +r_4592,MGt2ec +r_4598,BIOMASS_yeastGEM_COFACTOR +r_4599,BIOMASS_yeastGEM_ION diff --git a/ComplementaryData/databases/DBnewGeneAnnotation.tsv b/ComplementaryData/databases/DBnewGeneAnnotation.tsv index c0f00797..42105136 100644 --- a/ComplementaryData/databases/DBnewGeneAnnotation.tsv +++ b/ComplementaryData/databases/DBnewGeneAnnotation.tsv @@ -1,306 +1,306 @@ -NO gene annotation_SGD ec_SGD protein_name_SGD annotation_uniprot ec_uniprot protein_name_uniprot annotation_kegg ec_kegg annotation_biocyc annotation_reactome reaction_found_in_Rhea_based_on_ecSGD reaction_found_in_Brenda_based_on_ecSGD reaction_found_in_Rhea_based_on_ecUniprot reaction_found_in_Brenda_based_on_ecUniprot reaction_biocyc reaction_kegg reaction_reactome Annotation_score reaction_uniprot Choosed_reaction manual_check subpathway note sign_for_ec_from_ecoli_human subsystem_SGD subsystem_uniprot subsystem_kegg subsystem_biocyc subsystem_reactome pathway_comprehensive compartment_uni compartment_sgd common_compartment -5 YAL026C "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ YES phospholipids transport "pathway from reactome;3.6.3.1 many transport reactions in human model" "E586;H449" "Neutrophil degranulation;Ion transport by P-type ATPases" NA Golgi "Golgi membrane;endoplasmic reticulum;Golgi;cell envelope" Golgi -7 YAL035W "Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2" 3.6.5.3 Translation initiation factor eIF5B Plays a role in translation initiation (PubMed:9624054). Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:12507428, PubMed:12471154, PubMed:12008673). GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome (PubMed:25478828). The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes (PubMed:12507428, PubMed:18976658, PubMed:19029250). Stimulates 20S pre-rRNA cleavage to mature 18S rRNA by PIN-domain endonuclease NOB1 (PubMed:22751017). {ECO:0000269|PubMed:12008673, ECO:0000269|PubMed:12471154, ECO:0000269|PubMed:12507428, ECO:0000269|PubMed:18976658, ECO:0000269|PubMed:19029250, ECO:0000269|PubMed:22751017, ECO:0000269|PubMed:25478828, ECO:0000269|PubMed:9624054}. 3.6.5.3 Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) "FUN12, yIF2; translation initiation factor eIF5B" NA Function Unknown Now NA NA "GTP + H2O = GDP + phosphate;XTP + H2O = XDP + phosphate;XDP + H2O = XMP + phosphate" NA "GTP + H2O = GDP + phosphate;XTP + H2O = XDP + phosphate;XDP + H2O = XMP + phosphate" NA NA NA 5 out of 5 GTP + H(2)O = GDP + phosphate. {ECO:0000269|PubMed:12507428, ECO:0000269|PubMed:18976658}. GTP + H(2)O = GDP + phosphate YES Nucleotide Salvage Pathway from e.coli NA E450 NA NA RNA transport NA NA NA cytoplasm "cytoplasm;mitochondrion" cytoplasm -8 YAL039C "Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in mitochondrial intermembrane space; human homolog HCCS implicated in microphthalmia with linear skin defects (MLS), and can complement yeast null mutant" 4.4.1.17 Cytochrome c heme lyase (holocytochrome c synthase) Links covalently the heme group to the apoprotein of cytochrome c. 4.4.1.17 Cytochrome c heme lyase (CCHL) (EC 4.4.1.17) (Holocytochrome-c synthase) "CYC3; holocytochrome c synthase CYC3" 4.4.1.17 cytochrome c heme lyase "holo-[cytochrome c] => apo-[cytochrome c] + heme b;apo-[cytochrome c] + heme b => holo-[cytochrome c]" "Cytochrome c <=> Apocytochrome c + Heme;c-type cytochrome = heme c + apo-[c-type cytochrome];Holocytochrome c = apocytochrome c + heme" "holo-[cytochrome c] => apo-[cytochrome c] + heme b;apo-[cytochrome c] + heme b => holo-[cytochrome c]" "Cytochrome c <=> Apocytochrome c + Heme;c-type cytochrome = heme c + apo-[c-type cytochrome];Holocytochrome c = apocytochrome c + heme" a c-type cytochrome <=> heme c + an apo-[c-type cytochrome] Cytochrome c <=> Apocytochrome c + Heme 3 out of 5 Holocytochrome c = apocytochrome c + heme. Cytochrome c <=> Apocytochrome c + Heme YES Porphyrin and chlorophyll metabolism pathway from kegg H991 Porphyrin and chlorophyll metabolism "Porphyrin and chlorophyll metabolism;path:map00860" mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -9 YAL061W "Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3" 1.1.1.303 Putative medium-chain alcohol dehydrogenase with similarity to BDH1 Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH. {ECO:0000305}. 1.1.1.303 Probable diacetyl reductase [(R)-acetoin forming] 2 (EC 1.1.1.303) "BDH2; putative dehydrogenase BDH2" "1.1.1.4;1.1.1.303" BDH2 "(R)-acetoin + NAD(+) => diacetyl + H(+) + NADH;diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)" (R)-acetoin + NAD+ = diacetyl + NADH + H+ "(R)-acetoin + NAD(+) => diacetyl + H(+) + NADH;diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)" (R)-acetoin + NAD+ = diacetyl + NADH + H+ "(R)-Acetoin + NAD+ <=> Diacetyl + NADH + H+;(R,R)-Butane-2,3-diol + NAD+ <=> (R)-Acetoin + NADH + H+;meso-2,3-Butanediol + NAD+ <=> (S)-Acetoin + NADH + H+" 3 out of 5 (R)-acetoin + NAD(+) = diacetyl + NADH. (R)-acetoin + NAD(+) <=> diacetyl + NADH YES Butanoate metabolism pathway from kegg Butanoate metabolism "Butanoate metabolism;path:map00650" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -21 YBL035C "B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation" B subunit of DNA polymerase alpha-primase complex Non-catalytic component of DNA polymerase alpha, which in a complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase. POL12 may play an essential role at the early stage of chromosomal DNA replication by coupling DNA polymerase alpha to the cellular replication machinery (By similarity). Interacts with MCM10. {ECO:0000250}. DNA polymerase alpha subunit B (DNA polymerase I subunit B) (DNA polymerase alpha:primase complex p86 subunit) (Pol alpha-primase complex p86 subunit) (DNA polymerase-primase complex p74 subunit) "POL12; DNA-directed DNA polymerase alpha subunit POL12" POLymerase "Detection of damage during initiation of DNA synthesis in S-phase;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere;RFC binding displaces Pol Alpha on the C-strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin;RFC binding displaces Pol Alpha;Loading of PCNA - Sliding Clamp Formation;RFC dissociates after sliding clamp formation;Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 NA 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA polymerase . Pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication" "Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand" NA nucleus nucleus nucleus -26 YBL057C "One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1" 3.1.1.29 One of two mitochondrially-localized peptidyl-tRNA hydrolases The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. {ECO:0000250, ECO:0000269|PubMed:12475929, ECO:0000269|PubMed:12799450}. 3.1.1.29 Peptidyl-tRNA hydrolase 2 (PTH 2) (EC 3.1.1.29) "PTH2; aminoacyl-tRNA hydrolase" 3.1.1.29 Peptidyl-Trna Hydrolase "N-acyl-L-alpha-aminoacyl-tRNA + H2O => an N-acyl-L-amino acid + H(+) + tRNA;an N-acyl-L-amino acid + H(+) + tRNA => N-acyl-L-alpha-aminoacyl-tRNA + H2O" "N-Substituted aminoacyl-tRNA + H2O <=> N-Substituted amino acid + tRNA;H2O + N-modified aminoacyl-[tRNA] = uncharged tRNA + N-modified amino acid + H+;L-asparaginyl-[tRNAasn] + H2O = L-asparagine + tRNAasn + H+;L-cysteinyl-[tRNAcys] + H2O = L-cysteine + tRNAcys + H+;N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA;diacetyl-lysyl-tRNALys + H2O = diacetyl-lysine + tRNALys;peptidyl-tRNAL + H2O = peptide + tRNA;peptidyl-tRNALys + H2O = peptide + tRNALys;peptidyl-tRNA + H2O = peptide + tRNA" "N-acyl-L-alpha-aminoacyl-tRNA + H2O => an N-acyl-L-amino acid + H(+) + tRNA;an N-acyl-L-amino acid + H(+) + tRNA => N-acyl-L-alpha-aminoacyl-tRNA + H2O" "N-Substituted aminoacyl-tRNA + H2O <=> N-Substituted amino acid + tRNA;H2O + N-modified aminoacyl-[tRNA] = uncharged tRNA + N-modified amino acid + H+;L-asparaginyl-[tRNAasn] + H2O = L-asparagine + tRNAasn + H+;L-cysteinyl-[tRNAcys] + H2O = L-cysteine + tRNAcys + H+;N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA;diacetyl-lysyl-tRNALys + H2O = diacetyl-lysine + tRNALys;peptidyl-tRNAL + H2O = peptide + tRNA;peptidyl-tRNALys + H2O = peptide + tRNALys;peptidyl-tRNA + H2O = peptide + tRNA" "an L-asparaginyl-[tRNAasn] + H2O => L-asparagine + tRNAasn + H+;an N-modified aminoacyl-[tRNA] + H2O => an uncharged tRNA + an N-modified amino acid + H+" 4 out of 5 N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA. N-acyl-L-alpha-aminoacyl-tRNA + H2O <=> an N-acyl-L-amino acid + H(+) + tRNA YES other "no subsystem from e.coli and human model; reaction from rhea" H1234 NA cytoplasm "cytoplasm;mitochondrion;mitochondrial membrane" cytoplasm -29 YBL080C "Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog" 6.3.5.- Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000269|PubMed:19417106}. 6.3.5.- Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112) "PET112; glutamyl-tRNA(Gln) amidotransferase subunit PET112" "6.3.5.6;6.3.5.7" PETite colonies "Glutaminyl-tRNA + L-Glutamate + Orthophosphate + ADP <=> L-Glutamyl-tRNA(Gln) + L-Glutamine + ATP + H2O;L-Asparaginyl-tRNA(Asn) + L-Glutamate + Orthophosphate + ADP <=> L-Aspartyl-tRNA(Asn) + L-Glutamine + ATP + H2O" 4 out of 5 ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. {ECO:0000255|HAMAP-Rule:MF_03147}. ATP + L-glutamyl-tRNA(Gln) + L-glutamine <=> ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate YES Aminoacyl-tRNA biosynthesis pathway from kegg "Aminoacyl-tRNA biosynthesis;Metabolic pathways" NA mitochondrion mitochondrion mitochondrion -30 YBL082C "Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; G353A missense mutation in human ortholog ALG3 implicated in carbohydrate deficient glycoprotein syndrome type IV, which is characterized by microcephaly, severe epilepsy, minimal psychomotor development, partial deficiency of sialic acids in serum glycoproteins; wild-type human ALG3 can complement yeast alg3 mutant" 2.4.1.258 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol. Sensitive to H.mrakii HM-1 killer toxin. {ECO:0000269|PubMed:11308030, ECO:0000269|PubMed:9108275}. 2.4.1.258 Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase) (HM-1 killer toxin resistance protein) "ALG3, RHK1; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase" 2.4.1.258 "dolichyl-P-Man:Man5GlcNAc2-PP-dolichol α-1,3-mannosyltransferase" Addition of the sixth mannose to the N-glycan precursor by ALG3. "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+ Dolichyl phosphate D-mannose + G00006 <=> Dolichyl phosphate + G10595 5 out of 5 Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:11308030}. Dolichyl phosphate D-mannose + G00006 <=> Dolichyl phosphate + G10595 YES N-Glycan biosynthesis pathway from kegg H1140 lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -32 YBL091C "Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p" 3.4.11.18 Methionine aminopeptidase Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays only a minor role in N-terminal methionine removal. Less efficient when the second residue is Val, Gly, Cys or Thr. {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:11811952, ECO:0000269|PubMed:12874831, ECO:0000269|PubMed:15547949, ECO:0000269|PubMed:8618900, ECO:0000269|PubMed:9177176}. 3.4.11.18 Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M) "MAP2; methionine aminopeptidase" 3.4.11.18 methionine aminopeptidase 2 "METAP1/2 demethylates GNAT1;Exocytosis of azurophil granule lumen proteins;Exocytosis of azurophil granule lumen proteins" "Met-Ala + H2O = Met + Ala;N-terminal-L-methionyl-L-alanyl-[protein] + H2O = N-terminal L-alanyl-[protein] + L-methionine;N-terminal-L-methionyl-L-cysteinyl-[protein] + H2O = N-terminal cysteinyl-[protein] + L-methionine;N-terminal-L-methionyl-glycyl-[protein] + H2O = N-terminal glycyl-[protein] + L-methionine;N-terminal-L-methionyl-L-seryl-[protein] + H2O = N-terminal L-seryl-[protein] + L-methionine;N-terminal-L-methionyl-L-threonyl-[protein] + H2O = N-terminal L-threonyl-[protein] + L-methionine;N-terminal-L-methionyl-L-valyl-[protein] + H2O = N-terminal L-valyl-[protein] + L-methionine;Met-peptide + H2O = Met + peptide" "Met-Ala + H2O = Met + Ala;N-terminal-L-methionyl-L-alanyl-[protein] + H2O = N-terminal L-alanyl-[protein] + L-methionine;N-terminal-L-methionyl-L-cysteinyl-[protein] + H2O = N-terminal cysteinyl-[protein] + L-methionine;N-terminal-L-methionyl-glycyl-[protein] + H2O = N-terminal glycyl-[protein] + L-methionine;N-terminal-L-methionyl-L-seryl-[protein] + H2O = N-terminal L-seryl-[protein] + L-methionine;N-terminal-L-methionyl-L-threonyl-[protein] + H2O = N-terminal L-threonyl-[protein] + L-methionine;N-terminal-L-methionyl-L-valyl-[protein] + H2O = N-terminal L-valyl-[protein] + L-methionine;Met-peptide + H2O = Met + peptide" a peptide with an N-terminal L-methionine + H2O => L-methionine + a peptide + H+ 5 out of 5 Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:8618900}. Met-Ala + H2O <=> Met + Ala YES other "Met-Ala + H2O = Met + Ala; hydrolysis of peptide bond" "Inactivation, recovery and regulation of the phototransduction cascade;Neutrophil degranulation" NA cytoplasm "nucleus;cytoplasm" cytoplasm -34 YBR001C "Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication" 3.2.1.28 Putative neutral trehalase, required for thermotolerance 3.2.1.28 Probable trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) "NTH2; alpha,alpha-trehalase NTH2" 3.2.1.28 neutral trehalase "alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose;alpha-D-glucose + beta-D-glucose => alpha,alpha-trehalose + H2O" "alpha,alpha-trehalose + H2O = 2 beta-D-glucose;alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose" "alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose;alpha-D-glucose + beta-D-glucose => alpha,alpha-trehalose + H2O" "alpha,alpha-trehalose + H2O = 2 beta-D-glucose;alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose" alpha,alpha-trehalose + H2O => beta-D-glucopyranose + alpha-D-glucopyranose alpha,alpha-Trehalose + H2O <=> 2 D-Glucose 3 out of 5 Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose. alpha,alpha-Trehalose + H2O <=> 2 D-Glucose YES Starch and sucrose metabolism pathway from kegg "E240;H561" "Starch and sucrose metabolism;Metabolic pathways" chitin biosynthesis // trehalose degradation II (trehalase) "Starch and sucrose metabolism;path:map00500;Metabolic pathways;path:map01100" "cytoplasm;mitochondrion" -35 YBR022W "Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing" "3.1.3.84;3.2.2.-" Phosphatase that is highly specific for ADP-ribose 1''-phosphate Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. {ECO:0000269|PubMed:10550052, ECO:0000269|PubMed:15684411, ECO:0000269|PubMed:23474712}. "3.1.3.84; 3.2.2.-" ADP-ribose 1''-phosphate phosphatase (EC 3.1.3.84) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase) "POA1; ADP-ribose 1''-phosphate phosphatase" 3.1.3.84 ADP-ribose 1''-phosphate phosphatase "ADP-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate;ADP-D-ribose + phosphate => ADP-D-ribose 1''-phosphate + H2O" ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate "ADP-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate;ADP-D-ribose + phosphate => ADP-D-ribose 1''-phosphate + H2O" ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate ADP ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate 3 out of 5 ADP-D-ribose 1''-phosphate + H(2)O = ADP-D-ribose + phosphate. ADP ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate YES other "NA;NA" tRNA splicing "NA;NA" -37 YBR046C "NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin" 1.6.5.5 NADPH-dependent quinone reductase 1.6.5.5 Probable quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) "ZTA1; NADPH:quinone reductase" 1.6.5.5 quinone oxidoreductase "2 a quinone + H(+) + NADPH => 2 a 1,4-benzosemiquinone + NADP(+);2 a 1,4-benzosemiquinone + NADP(+) => 2 a quinone + H(+) + NADPH" "2 Quinone + NADPH + H+ <=> 2 Semiquinone + NADP+;NADPH + quinone + H+ = NADP+ + semiquinone;NADPH + H+ + 2 quinone = NADP+ + 2 semiquinone" "2 a quinone + H(+) + NADPH => 2 a 1,4-benzosemiquinone + NADP(+);2 a 1,4-benzosemiquinone + NADP(+) => 2 a quinone + H(+) + NADPH" "2 Quinone + NADPH + H+ <=> 2 Semiquinone + NADP+;NADPH + quinone + H+ = NADP+ + semiquinone;NADPH + H+ + 2 quinone = NADP+ + 2 semiquinone" 2 a quinone + NADPH + H+ => 2 a semiquinone + NADP+ 3 out of 5 NADPH + 2 quinone = NADP(+) + 2 semiquinone. 2 a quinone + H(+) + NADPH <=> 2 a 1,4-benzosemiquinone + NADP(+) YES Tyrosine metabolism "pathway from recon3D; reaction from rhea" H676 NA "nucleus;cytoplasm" -41 YBR070C "Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to ER membrane; similar to bacterial and human glycosyltransferases; both human homologs ALG13 and ALG14 are required to complement yeast alg14 mutant" Component of UDP-GlcNAc transferase Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER. {ECO:0000269|PubMed:15615718, ECO:0000269|PubMed:16100110}. UDP-N-acetylglucosamine transferase subunit ALG14 (Asparagine-linked glycosylation protein 14) "ALG14; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14" 2.4.1.141 UDP-N-acetylglucosamine transferase Alg14p subunit ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP + H+ UDP-N-acetyl-D-glucosamine + N-Acetyl-D-glucosaminyldiphosphodolichol <=> UDP + N,N'-Chitobiosyldiphosphodolichol 5 out of 5 NA UDP-N-acetyl-D-glucosamine + N-Acetyl-D-glucosaminyldiphosphodolichol <=> UDP + N,N'-Chitobiosyldiphosphodolichol YES N-Glycan biosynthesis Essential for the second step of the dolichol-linked oligosaccharide pathway. Pathway from kegg lipid-linked oligosaccharide biosynthesis "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein NA "endoplasmic reticulum membrane;nucleus" "nucleus;endoplasmic reticulum;endoplasmic reticulum membrane" "nucleus;endoplasmic reticulum membrane" -45 YBR111C "Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate" 3.6.1.13 Nudix hydrolase family member with ADP-ribose pyrophosphatase activity 3.6.1.13 ADP-ribose pyrophosphatase (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) "YSA1, RMA2; ADP-ribose diphosphatase" 3.6.1.13 YSA1 Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP "ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate;GDP-mannose + H2O = GMP + D-mannose 1-phosphate;ADP-glucose + H2O = AMP + alpha-D-glucose 1-phosphate;ADP-mannose + H2O = AMP + D-mannose 1-phosphate" "ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate;GDP-mannose + H2O = GMP + D-mannose 1-phosphate;ADP-glucose + H2O = AMP + alpha-D-glucose 1-phosphate;ADP-mannose + H2O = AMP + D-mannose 1-phosphate" ADP-D-ribose + H2O = AMP + D-ribofuranose 5-phosphate + 2 H+ ADP-ribose + H2O <=> AMP + D-Ribose 5-phosphate Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP 4 out of 5 ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate. ADP-D-ribose + H2O <=> AMP + D-ribofuranose 5-phosphate + 2 H+ YES Purine metabolism pathway from kegg "E332;H61" Purine metabolism Phosphate bond hydrolysis by NUDT proteins "Purine metabolism;path:map00230" "nucleus;cytoplasm;mitochondrion" -51 YBR147W "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" Putative vacuolar membrane transporter for cationic amino acids May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) "RTC2, RRT11, YPQ3; cationic amino acid transporter" Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 4 out of 5 NA " L-Arg <=> L-Arg; L-His <=> L-His; L-Lys <=> L-Lys" YES "L-Arg transport (from lysosomal lumen to cytosol); L-His transport (from lysosomal lumen to cytosol); L-Lys transport (from lysosomal lumen to cytosol)" cationic amino acids transport Miscellaneous transport and binding events NA "vacuolar membrane;mitochondrial membrane" "mitochondrion;vacuole;vacuolar membrane;mitochondrial membrane" "mitochondrial membrane;vacuolar membrane" -52 YBR154C "RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation" RNA polymerase subunit ABC27 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerase complexes are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (ABC27) (DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide) "RPB5; DNA-directed RNA polymerase core subunit RPB5" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Binding of RRN3 to RNA Polymerase I;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase RNA polymerase. Pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase I Transcription Initiation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus -56 YBR177C "Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication" "2.3.1.84;3.1.1.-" Acyl-coenzymeA:ethanol O-acyltransferase Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification. {ECO:0000269|PubMed:16361250}. "2.3.1.84; 3.1.1.-" Medium-chain fatty acid ethyl ester synthase/esterase 2 (Alcohol O-acetyltransferase) (EC 2.3.1.84) (EC 3.1.1.-) (Ethanol hexanoyl transferase 1) "EHT1; medium-chain fatty acid ethyl ester synthase/esterase" NA alcohol acyl transferase ABHD3 hydrolyses LPC(14:0) to 1AGPC "acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA;an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol" "acetyl-CoA + a primary alcohol = CoA + an acetyl ester;butanol + acetyl-CoA = butyl acetate + CoA;phenylethyl alcohol + acetyl-CoA = phenylethyl acetate + CoA;geraniol + acetyl-CoA = CoA + geranyl acetate;coniferyl alcohol + acetyl-CoA = coniferyl acetate + CoA;isoamylalcohol + acetyl-CoA = isoamyl acetate + CoA;acetyl-CoA + alcohol = CoA + acetate" "acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA;an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol" "acetyl-CoA + a primary alcohol = CoA + an acetyl ester;butanol + acetyl-CoA = butyl acetate + CoA;phenylethyl alcohol + acetyl-CoA = phenylethyl acetate + CoA;geraniol + acetyl-CoA = CoA + geranyl acetate;coniferyl alcohol + acetyl-CoA = coniferyl acetate + CoA;isoamylalcohol + acetyl-CoA = isoamyl acetate + CoA;acetyl-CoA + alcohol = CoA + acetate" "butan-1-ol + acetyl-CoA => butyl acetate + coenzyme A;ethanol + acetyl-CoA => ethyl acetate + coenzyme A" NA ABHD3 hydrolyses LPC(14:0) to 1AGPC 5 out of 5 Acetyl-CoA + an alcohol = CoA + an acetyl ester. Acetyl-CoA + an alcohol = CoA + an acetyl ester YES Other NA "NA;NA" NA NA NA NA Synthesis of PC "NA;NA" "mitochondrion;mitochondrial membrane;lipid particle" -58 YBR222C "Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase" 6.-.-.- Oxalyl-CoA synthetase Non-essential protein involved in fatty acid metabolism. 6.-.-.- Peroxisomal-coenzyme A synthetase (EC 6.-.-.-) "PCS60, FAT2; Pcs60p" 6.2.1.8 PCS60 "ACSF2 ligates CoA-SH to MCFA;ACSF3 ligates CoA-SH to VLCFA" ATP + Oxalate + CoA <=> AMP + Diphosphate + Oxalyl-CoA ACSF3 ligates CoA-SH to VLCFA 4 out of 5 NA ATP + Oxalate + CoA <=> AMP + Diphosphate + Oxalyl-CoA YES Glyoxylate and dicarboxylate metabolism pathway from kegg Glyoxylate and dicarboxylate metabolism "Synthesis of very long-chain fatty acyl-CoAs;Mitochondrial Fatty Acid Beta-Oxidation" NA peroxisome "cytoplasm;peroxisome" peroxisome -59 YBR229C "Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations" 3.2.1.84 Glucosidase II catalytic subunit Catalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. {ECO:0000269|PubMed:16373354, ECO:0000269|PubMed:8910335}. 3.2.1.84 Glucosidase 2 subunit alpha (EC 3.2.1.84) (Alpha-glucosidase II subunit alpha) (Glucosidase II subunit alpha) (Reversal of TOR2 lethality protein 2) "ROT2, GLS2; glucan 1,3-alpha-glucosidase ROT2" 3.2.1.84 "α-glucosidase II α subunit" "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose;Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose;sucrose + H2O => glucose + fructose;sucrose + H2O => glucose + fructose;maltose + H2O => 2 D-glucose (maltase-glucoamylase);maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase);maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase);maltose + H2O => 2 D-glucose (sucrase-isomaltase);maltose + H2O => 2 D-glucose (sucrase-isomaltase);maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase);GAA hydrolyzes alpha(1,6) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,6) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,4) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,4) linkages in lysosomal glycogen;Removal of the third glucose by glucosidase II and release from the chaperone;isomaltose + H2O => 2 D-glucose (sucrase-isomaltase);isomaltose + H2O => 2 D-glucose (sucrase-isomaltase);Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins" "nigerose + H2O = 2 D-glucose;H2O + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;H2O + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GlcMan7GlcNAc2 + H2O = Man7GlcNAc2 + D-glucose;mutan = glucan;alpha-1,3-mutan + H2O = alpha-D-glucose;Glc2Man9GlcNAc2 + H2O = Man9GlcNAc2 + alpha-D-glucose" "nigerose + H2O = 2 D-glucose;H2O + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;H2O + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GlcMan7GlcNAc2 + H2O = Man7GlcNAc2 + D-glucose;mutan = glucan;alpha-1,3-mutan + H2O = alpha-D-glucose;Glc2Man9GlcNAc2 + H2O = Man9GlcNAc2 + alpha-D-glucose" "a [protein]-L-asparagine-[(glucosyl)2(mannosyl)9(N-acetylglucosaminyl)2] + H2O => a [protein]-L-asparagine-[glucosyl(mannosyl)9(N-acetylglucosaminyl)2] + D-glucopyranose;a [protein]-L-asparagine-[glucosyl(mannosyl)9(N-acetylglucosaminyl)2] + H2O => a [protein]-L-asparagine-[(mannosyl)9(N-acetylglucosaminyl)2] + D-glucopyranose" "H2O + G00171 <=> D-Glucose + G00010;H2O + G00010 <=> D-Glucose + G00011" "GAA hydrolyzes alpha(1,6) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,6) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,4) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,4) linkages in lysosomal glycogen" 5 out of 5 Hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D-glucans. "H2O + G00171 <=> D-Glucose + G00010;H2O + G00010 <=> D-Glucose + G00011" YES N-Glycan biosynthesis pathway from kegg "PATHWAY: Glycan metabolism; N-glycan metabolism." "N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (yeast) processing in the ER "Digestion of dietary carbohydrate;Lysosomal glycogen catabolism;Neutrophil degranulation;Calnexin/calreticulin cycle" "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum "mitochondrion;endoplasmic reticulum" endoplasmic reticulum -60 YBR235W "Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family" Vacuolar membrane cation-chloride cotransporter (CCC) Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation. {ECO:0000305|PubMed:23022132}. Vacuolar cation-chloride cotransporter 1 (Vacuolar homolog of CCC family protein 1) "VHC1; Vhc1p" Vacuolar protein Homologous to CCC family "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol;SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol;SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region" "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol;SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol;SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region" 4 out of 5 NA "Na+ <=> Na+; K+ <=> K+; Cl- <=> Cl-" YES "chloride transport; K+ transport; Na transport" Cation-coupled Cation-coupled Chloride cotransporters NA vacuolar membrane "vacuole;vacuolar membrane" vacuolar membrane -63 YBR241C "Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene; YBR241C has a paralog, VPS73, that arose from the whole genome duplication" NA Putative transporter, member of the sugar porter family NA NA Probable metabolite transport protein YBR241C hypothetical protein NA YBR241C "SLC2A5 transports fructose from extracellular region to cytosol;SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT7 and GLUT11 transport glucose and fructose;GLUT7 and GLUT11 transport glucose and fructose;SLC2A9 transports Fru, Glc, urate;GLUT1 tetramer binds 4xATP;GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP;GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol;SLC2A1 tetramer transports Glc from cytosol to Golgi lumen;Exocytosis of secretory granule membrane proteins;Exocytosis of secretory granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol;GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol;GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol;GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" NA NA NA NA NA NA "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT7 and GLUT11 transport glucose and fructose;GLUT7 and GLUT11 transport glucose and fructose;SLC2A9 transports Fru, Glc, urate;GLUT1 tetramer binds 4xATP;GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP;GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol;SLC2A1 tetramer transports Glc from cytosol to Golgi lumen;Exocytosis of secretory granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol;GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol;GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol;GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" 2 out of 5 NA " Fru <=> Fru; Gal <=> Gal; Glc <=> Glc" YES sugar transport sugar transport NA NA NA NA NA "Cellular hexose transport;Vitamin C (ascorbate) metabolism;Regulation of insulin secretion;Lactose synthesis;Neutrophil degranulation;Intestinal hexose absorption" NA vacuolar membrane "vacuole;vacuolar membrane" vacuolar membrane -64 YBR243C "UDP-N-acetyl-glucosamine-1-P transferase; transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin; human homolog DPAGT1 can complement yeast ALG7 mutant" 2.7.8.15 UDP-N-acetyl-glucosamine-1-P transferase Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides. 2.7.8.15 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (G1PT) (GPT) (N-acetylglucosamine-1-phosphate transferase) (Tunicamycin resistance protein 1) "ALG7, TUR1; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" 2.7.8.15 "UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase" Addition of N-acetyl-D-glucosamine to Dolichyl phosphate "dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP;N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP => dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol;UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP" "dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP;N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP => dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol;UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP" a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP UDP-N-acetyl-alpha-D-glucosamine + Dolichyl phosphate <=> UMP + N-Acetyl-D-glucosaminyldiphosphodolichol 5 out of 5 UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol. UDP-N-acetyl-alpha-D-glucosamine + Dolichyl phosphate <=> UMP + N-Acetyl-D-glucosaminyldiphosphodolichol YES N-Glycan biosynthesis pathway from kegg H289 lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -69 YBR278W "Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication" 2.7.7.7 Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. {ECO:0000269|PubMed:12124389}. 2.7.7.7 DNA polymerase epsilon subunit C (EC 2.7.7.7) (DNA polymerase II subunit C) "DPB3; DNA polymerase epsilon noncatalytic subunit" 2.7.7.7 DNA Polymerase B (II) subunit "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus -70 YBR281C "Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" 3.4.-.- Component of glutamine amidotransferase (GATase II) Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. {ECO:0000269|PubMed:17179087}. 3.4.-.- Probable di- and tripeptidase DUG2 (EC 3.4.-.-) (Deficient in utilization of glutathione protein 2) (GSH degradosomal complex subunit DUG2) "DUG2; glutamine amidotransferase subunit DUG2" Deficient in Utilization of Glutathione glutathione + H2O => L-cysteinyl-glycine + L-glutamate 5 out of 5 NA glutathione + H2O => L-cysteinyl-glycine + L-glutamate YES Glutathione metabolism pathway from biocyc. It is changed into Glutathione metabolism "H1096;H1295" glutathione degradation (DUG pathway) NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -72 YBR295W "Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function" 3.6.3.3 Cadmium transporting P-type ATPase Cadmium transporting P-type ATPase which plays a critical role in cadmium resistance by extruding intracellular cadmium. Capable of high affinity copper ion binding, but not active copper ion transport. May play a role in copper resistance by chelating and sequestering copper ions. {ECO:0000269|PubMed:10743563, ECO:0000269|PubMed:14534306, ECO:0000269|PubMed:17107946, ECO:0000269|PubMed:18753133, ECO:0000269|PubMed:21483812, ECO:0000269|PubMed:2249249, ECO:0000269|PubMed:7754711}. 3.6.3.3 P-type cation-transporting ATPase (EC 3.6.3.3) (Cadmium resistance protein 2) (Cadmium-translocating P-type ATPase) (Cd(2+)-exporting ATPase) "PCA1, CAD2, PAY2; cation-transporting P-type ATPase PCA1" 3.6.3.4 P-type Cation-transporting ATPase "ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate;ADP + Cd(2+)(out) + H(+) + phosphate => ATP + Cd(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Cd2+/in = ADP + phosphate + Cd2+/out;ATP + H2O + Pb2+/in = ADP + phosphate + Pb2+/out" "ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate;ADP + Cd(2+)(out) + H(+) + phosphate => ATP + Cd(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Cd2+/in = ADP + phosphate + Cd2+/out;ATP + H2O + Pb2+/in = ADP + phosphate + Pb2+/out" Cd2+[in] + ATP + H2O = Cd2+[out] + ADP + phosphate + H+ ATP + H2O <=> ADP + Orthophosphate 5 out of 5 ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out). Cd2+[in] + ATP + H2O <=> Cd2+[out] + ADP + phosphate + H+ YES Cadmium transport "E586;E622" NA cell envelope cell envelope cell envelope -73 YCL017C "Cysteine desulfurase; involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria" 2.8.1.7 Cysteine desulfurase Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs. {ECO:0000269|PubMed:10406803, ECO:0000269|PubMed:10551871, ECO:0000269|PubMed:14722066, ECO:0000269|PubMed:15220327, ECO:0000269|PubMed:8444805}. 2.8.1.7 Cysteine desulfurase, mitochondrial (EC 2.8.1.7) (tRNA-splicing protein SPL1) "NFS1, SPL1; Nfs1p" 2.8.1.7 L-cysteine desulfurase "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster;Frataxin binds iron;Sec is reduced to H2Se by SCLY;NFS1 transfers sulfur from cysteine onto MOCS3" "(sulfur carrier)-H + L-cysteine => (sulfur carrier)-SH + L-alanine;(sulfur carrier)-SH + L-alanine => (sulfur carrier)-H + L-cysteine" "L-cysteine sulfinic acid = L-alanine + sulfite;L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor;[Enzyme]-cysteine + L-Cysteine <=> [Enzyme]-S-sulfanylcysteine + L-Alanine;L-Cysteine + [Protein]-L-cysteine <=> L-Alanine + [Protein]-S-sulfanyl-L-cysteine;[Enzyme]-S-sulfanylcysteine + [Protein]-L-cysteine <=> [Enzyme]-cysteine + [Protein]-S-sulfanyl-L-cysteine;[L-cysteine desulfurase] L-cysteine persulfide + unsulfurated [sulfur carrier] = [L-cysteine desulfurase]-L-cysteine + sulfurated [sulfur carrier];L-cysteine + unsulfurated [sulfur carrier] = L-alanine + sulfurated [sulfur carrier];S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex = [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex;[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-cysteine = S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-alanine;S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex = [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex;[L-cysteine desulfurase] + L-cysteine = S-sulfanyl-[L-cysteine desulfurase] + L-alanine;ThiI sulfur-carrier protein + L-cysteine = S-sulfanyl-[ThiI sulfur-carrier protein] + L-alanine;[L-cysteine desulfurase]-L-cysteine + L-cysteine = [L-cysteine desulfurase] L-cysteine persulfide + L-alanine;[enzyme]-S-sulfanylcysteine + acceptor = [enzyme]-cysteine + S-sulfanyl-acceptor;L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine;L-cysteine + Slr0077 = L-alanine + Slr0077-SSH;L-cysteine + IscS = L-alanine + IscS-SSH;L-cysteine + RhdA = L-alanine + RhdA-SSH;L-cysteine + SufS = L-alanine + SufS-SSH;L-cysteine = L-alanine + sulfur;L-cysteine + MOC3 protein = L-alanine + S-sulfanyl-MOC3 protein;L-cysteine + SufE = L-alanine + S-sulfanyl-SufE" "(sulfur carrier)-H + L-cysteine => (sulfur carrier)-SH + L-alanine;(sulfur carrier)-SH + L-alanine => (sulfur carrier)-H + L-cysteine" "L-cysteine sulfinic acid = L-alanine + sulfite;L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor;[Enzyme]-cysteine + L-Cysteine <=> [Enzyme]-S-sulfanylcysteine + L-Alanine;L-Cysteine + [Protein]-L-cysteine <=> L-Alanine + [Protein]-S-sulfanyl-L-cysteine;[Enzyme]-S-sulfanylcysteine + [Protein]-L-cysteine <=> [Enzyme]-cysteine + [Protein]-S-sulfanyl-L-cysteine;[L-cysteine desulfurase] L-cysteine persulfide + unsulfurated [sulfur carrier] = [L-cysteine desulfurase]-L-cysteine + sulfurated [sulfur carrier];L-cysteine + unsulfurated [sulfur carrier] = L-alanine + sulfurated [sulfur carrier];S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex = [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex;[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-cysteine = S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-alanine;S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex = [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex;[L-cysteine desulfurase] + L-cysteine = S-sulfanyl-[L-cysteine desulfurase] + L-alanine;ThiI sulfur-carrier protein + L-cysteine = S-sulfanyl-[ThiI sulfur-carrier protein] + L-alanine;[L-cysteine desulfurase]-L-cysteine + L-cysteine = [L-cysteine desulfurase] L-cysteine persulfide + L-alanine;[enzyme]-S-sulfanylcysteine + acceptor = [enzyme]-cysteine + S-sulfanyl-acceptor;L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine;L-cysteine + Slr0077 = L-alanine + Slr0077-SSH;L-cysteine + IscS = L-alanine + IscS-SSH;L-cysteine + RhdA = L-alanine + RhdA-SSH;L-cysteine + SufS = L-alanine + SufS-SSH;L-cysteine = L-alanine + sulfur;L-cysteine + MOC3 protein = L-alanine + S-sulfanyl-MOC3 protein;L-cysteine + SufE = L-alanine + S-sulfanyl-SufE" "a [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-cysteine => an S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-alanine;an S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex => a [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex;an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex => a [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex;an [L-cysteine desulfurase] L-cysteine persulfide + an unsulfurated [sulfur carrier] <=> an [L-cysteine desulfurase]-L-cysteine + a sulfurated [sulfur carrier];an [L-cysteine desulfurase]-L-cysteine + L-cysteine => an [L-cysteine desulfurase] L-cysteine persulfide + L-alanine;L-cysteine + an unsulfurated [sulfur carrier] => L-alanine + a sulfurated [sulfur carrier]" "[Enzyme]-cysteine + L-Cysteine <=> [Enzyme]-S-sulfanylcysteine + L-Alanine;L-Cysteine + [Protein]-L-cysteine <=> L-Alanine + [Protein]-S-sulfanyl-L-cysteine;[Enzyme]-S-sulfanylcysteine + [Protein]-L-cysteine <=> [Enzyme]-cysteine + [Protein]-S-sulfanyl-L-cysteine" "Sec is reduced to H2Se by SCLY;NFS1 transfers sulfur from cysteine onto MOCS3" 5 out of 5 L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor. {ECO:0000269|PubMed:15220327}. (sulfur carrier)-H + L-cysteine <=> (sulfur carrier)-SH + L-alanine YES iron-sulfur cluster biosynthesis "pathway from biocyc; reaction from rhea" "Thiamine metabolism;Metabolic pathways;Sulfur relay system" iron-sulfur cluster biosynthesis // tRNA-uridine 2-thiolation (yeast mitochondria) "Mitochondrial iron-sulfur cluster biogenesis;Metabolism of ingested SeMet, Sec, MeSec into H2Se;Molybdenum cofactor biosynthesis" "Thiamine metabolism;path:map00730;Metabolic pathways;path:map01100" mitochondrion "nucleus;mitochondrion" mitochondrion -77 YCL047C "Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion" 2.7.7.1 Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT) Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Involved in the salvage pathway for NAD(+) biosynthesis via NMN (PubMed:24759102). Involved in the filamentation pathway. Suppresses the filamentation defect of a KSS1 deletion (PubMed:21460040). {ECO:0000269|PubMed:21460040, ECO:0000269|PubMed:24759102}. 2.7.7.1 Nicotinamide mononucleotide adenylyltransferase (NMN adenylyltransferase) (NMNAT) (EC 2.7.7.1) (NMN-specific adenylyltransferase) (Promoter of filamentation protein 1) "POF1; nicotinamide-nucleotide adenylyltransferase" 2.7.7.1 Promoter Of Filamentation "beta-nicotinamide D-ribonucleotide + ATP + H(+) => diphosphate + NAD(+);diphosphate + NAD(+) => beta-nicotinamide D-ribonucleotide + ATP + H(+)" "ATP + nicotinamide ribonucleotide = diphosphate + NAD+;ATP + beta-nicotinate D-ribonucleotide = diphosphate + deamido-NAD+;tiazofurin monophosphate + ATP = tiazofurin adenine dinucleotide + diphosphate" "beta-nicotinamide D-ribonucleotide + ATP + H(+) => diphosphate + NAD(+);diphosphate + NAD(+) => beta-nicotinamide D-ribonucleotide + ATP + H(+)" "ATP + nicotinamide ribonucleotide = diphosphate + NAD+;ATP + beta-nicotinate D-ribonucleotide = diphosphate + deamido-NAD+;tiazofurin monophosphate + ATP = tiazofurin adenine dinucleotide + diphosphate" "ATP + Nicotinamide D-ribonucleotide <=> Diphosphate + NAD+;ATP + Nicotinate D-ribonucleotide <=> Diphosphate + Deamino-NAD+" 5 out of 5 ATP + nicotinamide ribonucleotide = diphosphate + NAD(+). {ECO:0000269|PubMed:24759102}. beta-nicotinamide D-ribonucleotide + ATP + H(+) <=> diphosphate + NAD(+) YES Nicotinate and nicotinamide metabolism "pathway from kegg; reaction from rhea" "E78;H422" "PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. {ECO:0000305|PubMed:24759102}." "Nicotinate and nicotinamide metabolism;Metabolic pathways" "Nicotinate and nicotinamide metabolism;path:map00760;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -81 YCR011C Putative ATP-dependent permease of the ABC transporter family Putative ATP-dependent permease of the ABC transporter family Probable ATP-dependent permease "ADP1; putative ATP-dependent permease ADP1" ATP-Dependent Permease "ABCG4 may mediate cholesterol efflux;ABCG1-mediated transport of intracellular cholesterol to the cell surface;ABCG2 dimer transports heme from cytosol to extracellular region" "ABCG4 may mediate cholesterol efflux;ABCG1-mediated transport of intracellular cholesterol to the cell surface" 3 out of 5 NA cholesterol <=> cholesterol YES cholesterol transport "ABC transporters in lipid homeostasis;HDL remodeling;Iron uptake and transport" NA endoplasmic reticulum membrane "vacuole;cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" endoplasmic reticulum membrane -82 YCR014C "DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta" 2.7.7.7 DNA polymerase IV Repair polymerase. Involved in gap-filling in DNA nonhomologous end joining (NHEJ) required for double-strand break repair. Seems to conduct DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Preferentially acts upon short gaps formed by the alignment of linear duplexes with complementary single-strand ends. Required for filling gaps that need removal of a 5'- or 3'-terminal mismatch, however lacks nuclease activities. {ECO:0000269|PubMed:10438542, ECO:0000269|PubMed:12235149, ECO:0000269|PubMed:8065914}. 2.7.7.7 DNA polymerase IV (POL IV) (EC 2.7.7.7) "POL4; DNA-directed DNA polymerase IV" 2.7.7.7 POLymerase "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA synthesis. Pathway obtained by comparing the ec H1117 Non-homologous end-joining "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus -88 YCR068W "Phospholipase; preferentially hydrolyses phosphatidylserine, with minor activity against cardiolipin and phosphatidylethanolamine; required for lysis of autophagic and CVT bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway; required for the maintenance of lipid droplet quantity after the diauxic shift; regulates lipolysis; expression regulated by Yap1p during autophagy" 3.1.1.3 Phospholipase Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension. {ECO:0000269|PubMed:11085977, ECO:0000269|PubMed:11264288, ECO:0000269|PubMed:11566994, ECO:0000269|PubMed:12499386, ECO:0000269|PubMed:18690010, ECO:0000269|PubMed:21364763, ECO:0000269|PubMed:21777356}. 3.1.1.3 Putative lipase ATG15 (EC 3.1.1.3) (Autophagy-related protein 15) (Cytoplasm to vacuole targeting protein 17) "ATG15, AUT5, CVT17; triglyceride lipase ATG15" 3.1.1.3 lipase "retinyl palmitate + H2O = retinol + palmitate;methyl acetate + H2O = methanol + acetate;tributyrin + H2O = dibutyrin + butyrate;1,2-Diacyl-sn-glycerol + H2O <=> 1-Acylglycerol + Fatty acid;triacylglycerol + H2O = diacylglycerol + a carboxylate;diacylglycerol + H2O = monoacylglycerol + a carboxylate;4-nitrophenyl butyrate + H2O = 4-nitrophenol + butyrate;triolein + H2O = diolein + oleate;Triacylglycerol + H2O <=> 1,2-Diacyl-sn-glycerol + Fatty acid;1,2-Diacyl-sn-glycerol + H2O <=> 2-Acylglycerol + Fatty acid;dietary all-trans-retinyl ester + H2O = all-trans-retinol + long-chain fatty acid + H+;triglyceride + H2O = 1,2-diglyceride + fatty acid + H+;tripalmitin + H2O = dipalmitin + palmitate;tricaprylin + H2O = dicaprylin + caprylate;trimyristin + H2O = dimyristin + myristate;(RS)-1-phenylethanol + vinyl acetate = (R)-1-phenylethyl acetate + acetaldehyde + (S)-1-phenylethanol" "retinyl palmitate + H2O = retinol + palmitate;methyl acetate + H2O = methanol + acetate;tributyrin + H2O = dibutyrin + butyrate;1,2-Diacyl-sn-glycerol + H2O <=> 1-Acylglycerol + Fatty acid;triacylglycerol + H2O = diacylglycerol + a carboxylate;diacylglycerol + H2O = monoacylglycerol + a carboxylate;4-nitrophenyl butyrate + H2O = 4-nitrophenol + butyrate;triolein + H2O = diolein + oleate;Triacylglycerol + H2O <=> 1,2-Diacyl-sn-glycerol + Fatty acid;1,2-Diacyl-sn-glycerol + H2O <=> 2-Acylglycerol + Fatty acid;dietary all-trans-retinyl ester + H2O = all-trans-retinol + long-chain fatty acid + H+;triglyceride + H2O = 1,2-diglyceride + fatty acid + H+;tripalmitin + H2O = dipalmitin + palmitate;tricaprylin + H2O = dicaprylin + caprylate;trimyristin + H2O = dimyristin + myristate;(RS)-1-phenylethanol + vinyl acetate = (R)-1-phenylethyl acetate + acetaldehyde + (S)-1-phenylethanol" a triglyceride + H2O => a 1,2-diglyceride + a fatty acid + H+ "Triacylglycerol + H2O <=> 1,2-Diacyl-sn-glycerol + Fatty acid;1,2-Diacyl-sn-glycerol + H2O <=> 1-Acylglycerol + Fatty acid" 5 out of 5 Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. "Triacylglycerol + H2O <=> 1,2-Diacyl-sn-glycerol + Fatty acid;1,2-Diacyl-sn-glycerol + H2O <=> 1-Acylglycerol + Fatty acid" YES Glycerolipid metabolism pathway from kegg "H367;H721;H1070" "Glycerolipid metabolism;Metabolic pathways;Autophagy - yeast" triacylglycerol degradation "Glycerolipid metabolism;path:map00561;Metabolic pathways;path:map01100" "endoplasmic reticulum membrane;Golgi membrane;cytoplasm" "Golgi membrane;cytoplasm;vacuole;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi" "Golgi membrane;endoplasmic reticulum membrane;cytoplasm" -92 YCR107W "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog, AAD15, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" Putative aryl-alcohol dehydrogenase 1.1.1.- Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) "AAD3; putative aryl-alcohol dehydrogenase" aryl-alcohol dehydrogenase "3-chlorobenzyl alcohol + NAD+ = 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ = 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ = 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ = p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ = 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ = an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ = benzaldehyde + NADH + H+" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism "pathway from E.coli model; reaction from biocyc" "E646;E743;H1286" NA -94 YEL002C "Beta subunit of the oligosaccharyl transferase glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum; human homolog DDOST can complement yeast growth defect during down-regulation of yeast gene" 2.4.99.18 Beta subunit of the oligosaccharyl transferase glycoprotein complex Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1 (Oligosaccharyl transferase subunit WBP1) (EC 2.4.99.18) (Oligosaccharyl transferase subunit beta) "WBP1; dolichyl-diphosphooligosaccharide-protein glycotransferase" NA "oligosaccharyl transferase complex β subunit" "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA NA 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis "pathway from kegg; reaction not sure" NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps Neutrophil degranulation "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "nucleus;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -95 YEL004W "Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER" Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc) and is required for cell wall chitin synthesis. {ECO:0000269|PubMed:10788474}. UDP-N-acetylglucosamine transporter YEA4 "YEA4; Yea4p" YEA4 "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen;SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen" "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen;SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen" 4 out of 5 NA UDP-GlcNAc <=> UDP-GlcNAc YES "Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transport; UDP-xylose[c] => UDP-xylose[g]; UDP-GlcNAc[c] <=> UDP-GlcNAc[g]" UDP-N-acetylglucosamine Transport of nucleotide sugars NA "endoplasmic reticulum;endoplasmic reticulum membrane" "endoplasmic reticulum;endoplasmic reticulum membrane;Golgi membrane" "endoplasmic reticulum;endoplasmic reticulum membrane" -96 YEL011W "Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease" 2.4.1.18 Glycogen branching enzyme, involved in glycogen accumulation 2.4.1.18 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Glycogen-branching enzyme) "GLC3, GHA1; 1,4-alpha-glucan branching enzyme" 2.4.1.18 1,4-glucan-6-(1,4-glucano)-transferase "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a;GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a;GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b" "glycogen + H2O = maltooligosaccharides;amylopectin + H2O = malto-oligosaccharides;1,4-alpha-D-glucan = (1,6)-alpha-D-glucosyl-(1,4)-alpha-glucan + H2O;glucosylated glycogenin = glycogen;2 1,4-alpha-D-glucan = alpha-1,4-D-glucan-alpha-1,6-(alpha-1,4-D-glucan) + H2O" "glycogen + H2O = maltooligosaccharides;amylopectin + H2O = malto-oligosaccharides;1,4-alpha-D-glucan = (1,6)-alpha-D-glucosyl-(1,4)-alpha-glucan + H2O;glucosylated glycogenin = glycogen;2 1,4-alpha-D-glucan = alpha-1,4-D-glucan-alpha-1,6-(alpha-1,4-D-glucan) + H2O" "a 1,4-alpha-D-glucan = a glycogen;a glucosylated glycogenin => a glycogen" Amylose <=> Starch "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a;GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a;GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b" 3 out of 5 Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. glygn1[c] => glygn2[c] YES Starch and sucrose metabolism pathway from kegg, reaction from human model, This reaction: [c] : glycogen --> bglycogen from E.coli, which is much simple. "E570;H281" glycogen biosynthesis "PATHWAY: Glycan biosynthesis; glycogen biosynthesis." "Starch and sucrose metabolism;path:map00500;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" glycogen biosynthesis Glycogen synthesis "Starch and sucrose metabolism;path:map00500;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" cytoplasm -101 YEL031W "P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1" 3.6.3.- P-type ATPase, ion transporter of the ER membrane Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. {ECO:0000269|PubMed:24392018}. 3.6.3.- Manganese-transporting ATPase 1 (EC 3.6.3.-) "SPF1, COD1, PER9, PIO1; ion-transporting P-type ATPase SPF1" Sensitivity to Pichia Farinosa killer toxin ATP13A1 transports Mn2+ from cytosol to ER lumen ATP13A1 transports Mn2+ from cytosol to ER lumen 5 out of 5 ATP + H(2)O = ADP + phosphate. Mn2+ <=> Mn2+ YES Mn2+ transport transports Mn2+ from cytosol to ER lumen Ion transport by P-type ATPases NA endoplasmic reticulum membrane "mitochondrion;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi;cell envelope" endoplasmic reticulum membrane -107 YEL064C "Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" NA Putative transporter Probable amino acid transporter of unknown specificity. {ECO:0000269|PubMed:11274162}. NA Vacuolar amino acid transporter 2 "AVT2; Avt2p" NA Amino acid Vacuolar Transport "Glutamine transport from astrocytes;L-Glutamine transport into neurons;SLC38A2 (ATA2)-mediated uptake of neutral amino acids;SLC38A1 (ATA1)-mediated uptake of neutral amino acids;SLC38A4 (ATA3)-mediated uptake of arginine and lysine;SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine;SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" NA NA NA NA NA NA "SLC38A4 (ATA3)-mediated uptake of arginine and lysine;SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine;SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" 3 out of 5 NA "arginine <=> arginine; lysine <=> lysine; glutamine <=> glutamine; histidine <=> histidine; asparagine <=> asparagine; alanine <=> alanine ; serine <=> serine" YES "amio acid transport; uptake of amino acids" NA NA NA NA NA "Astrocytic Glutamate-Glutamine Uptake And Metabolism;Glutamate Neurotransmitter Release Cycle;Amino acid transport across the plasma membrane" NA vacuolar membrane "vacuole;vacuolar membrane;endoplasmic reticulum" vacuolar membrane -108 YEL066W "D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; acetylates histones and polyamines, also autoacetylates" "2.3.1.36;2.3.1.48" D-Amino acid N-acetyltransferase that detoxifies D-amino acids N-acetyltransferase that acetylates histone H4 at 'Lys-8'. Also acetylates polyamines like putrescine, spermidine and spermine (PubMed:23775086). Acts on a wide range of D-amino acids. Catalyzes the N-acetylation through an ordered bi-bi mechanism, in which acetyl-CoA is the first substrate to be bound and CoA is the last product to be liberated (PubMed:15375647). D-amino acids are toxic for the cell and their N-acetylation, preceding removal from cells, plays an important role in detoxification of D-amino acids (PubMed:10600387, PubMed:16362288). {ECO:0000269|PubMed:10600387, ECO:0000269|PubMed:15375647, ECO:0000269|PubMed:16362288, ECO:0000269|PubMed:23775086}. "2.3.1.36; 2.3.1.48" D-amino-acid N-acetyltransferase HPA3 (DNT) (EC 2.3.1.36) (EC 2.3.1.48) (Histone and other protein acetyltransferase 3) "HPA3; D-amino-acid N-acetyltransferase" 2.3.1.36 Histone and other Protein Acetyltransferase "a D-amino acid + acetyl-CoA => an N-acetyl-D-amino acid + CoA + H(+);an N-acetyl-D-amino acid + CoA + H(+) => a D-amino acid + acetyl-CoA;[histone]-L-lysine + acetyl-CoA => [histone]-N(6)-acetyl-L-lysine + CoA + H(+);[histone]-N(6)-acetyl-L-lysine + CoA + H(+) => [histone]-L-lysine + acetyl-CoA;[protein]-L-lysine + acetyl-CoA => [protein]-N(6)-acetyl-L-lysine + CoA + H(+);[protein]-N(6)-acetyl-L-lysine + CoA + H(+) => [protein]-L-lysine + acetyl-CoA" "acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid;acetyl-CoA + D-phenylalanine = CoA + N-acetyl-D-phenylalanine;propionyl-CoA + D-alanine = CoA + N-propionyl-D-alanine;acetyl-CoA + D-cysteine = CoA + N-acetyl-D-cysteine;acetyl-CoA + D-tyrosine = CoA + N-acetyl-D-tyrosine;acetyl-CoA + D-leucine = CoA + N-acetyl-D-leucine;acetyl-CoA + D-threonine = CoA + N-acetyl-D-threonine;acetyl-CoA + D-valine = CoA + N-acetyl-D-valine;acetyl-CoA + D-alanine = CoA + N-acetyl-D-alanine;acetyl-CoA + D-glutamine = CoA + N-acetyl-D-glutamine;acetyl-CoA + D-asparagine = CoA + N-acetyl-D-asparagine;acetyl-CoA + D-asparaginate = CoA + N-acetyl-D-asparaginate;acetyl-CoA + D-histidine = CoA + N-acetyl-D-histidine;acetyl-CoA + D-norvaline = CoA + N-acetyl-D-norvaline;acetyl-CoA + D-serine = CoA + N-acetyl-D-serine;acetyl-CoA + D-cystine = CoA + N-acetyl-D-cystine;acetyl-CoA + D-isoleucine = CoA + N-acetyl-D-isoleucine;acetyl-CoA + norleucine = CoA + N-acetyl-D-norleucine;acetyl-CoA + D-proline = CoA + N-acetyl-D-proline;acetyl-CoA + D-methionine = CoA + N-acetyl-D-methionine;propionyl-CoA + D-leucine = CoA + N-propionyl-D-leucine;propionyl-CoA + D-glutamine = CoA + N-propionyl-D-glutamine;propionyl-CoA + D-allo-isoleucine = CoA + N-propionyl-D-allo-isoleucine;propionyl-CoA + D-serine = CoA + N-propionyl-D-serine;propionyl-CoA + D-tryptophan = CoA + N2-propionyl-D-tryptophan;Acetyl-CoA + Histone-L-lysine <=> CoA + Histone N6-acetyl-L-lysine;acetyl-CoA + [histone]-L-lysine = [histone]-N6-acetyl-L-lysine + coenzyme A + H+;acetyl-CoA + histone H4 = CoA + acetylhistone H4;4 acetyl-CoA + histone H4 = 4 CoA + tetraacetylhistone H4;histone H4 + acetyl-CoA = acetyl-histone H4 + CoA;acetyl-CoA + p53 = CoA + acetyl-p53;histone H3 + acetyl-CoA = acetyl-histone H3 + CoA;acetyl-CoA + histone H3 = CoA + acetylhistone H3;acetyl-CoA + histone H2A = CoA + acetylhistone H2A;piccoloNuA4 peptide + acetyl-CoA = acetyl-piccoloNuA4 peptide + CoA;acetyl-CoA + c-Myc = CoA + acetylated c-Myc;androgen receptor + acetyl-CoA = acetylated androgen receptor + CoA;acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine;acetyl-CoA + histone H = CoA + acetylhistone H;ATM kinase + acetyl-CoA = acetylated ATM kinase + CoA;promyelotic leukemia zinc finger gene + acetyl-CoA = acetylated promyelotic leukemia zinc finger gene + CoA;acetyl-CoA + beta-site amyloid precursor protein-cleaving enzyme 1 = CoA + acetylated beta-site amyloid precursor protein-cleaving enzyme 1;acetyl-CoA + p50 protein = CoA + acetyl-p50 protein;acetyl-CoA + p65 protein = CoA + acetyl-p65 protein;acetyl-CoA + histone = CoA + acetylhistone" "a D-amino acid + acetyl-CoA => an N-acetyl-D-amino acid + CoA + H(+);an N-acetyl-D-amino acid + CoA + H(+) => a D-amino acid + acetyl-CoA;[histone]-L-lysine + acetyl-CoA => [histone]-N(6)-acetyl-L-lysine + CoA + H(+);[histone]-N(6)-acetyl-L-lysine + CoA + H(+) => [histone]-L-lysine + acetyl-CoA;[protein]-L-lysine + acetyl-CoA => [protein]-N(6)-acetyl-L-lysine + CoA + H(+);[protein]-N(6)-acetyl-L-lysine + CoA + H(+) => [protein]-L-lysine + acetyl-CoA" "acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid;acetyl-CoA + D-phenylalanine = CoA + N-acetyl-D-phenylalanine;propionyl-CoA + D-alanine = CoA + N-propionyl-D-alanine;acetyl-CoA + D-cysteine = CoA + N-acetyl-D-cysteine;acetyl-CoA + D-tyrosine = CoA + N-acetyl-D-tyrosine;acetyl-CoA + D-leucine = CoA + N-acetyl-D-leucine;acetyl-CoA + D-threonine = CoA + N-acetyl-D-threonine;acetyl-CoA + D-valine = CoA + N-acetyl-D-valine;acetyl-CoA + D-alanine = CoA + N-acetyl-D-alanine;acetyl-CoA + D-glutamine = CoA + N-acetyl-D-glutamine;acetyl-CoA + D-asparagine = CoA + N-acetyl-D-asparagine;acetyl-CoA + D-asparaginate = CoA + N-acetyl-D-asparaginate;acetyl-CoA + D-histidine = CoA + N-acetyl-D-histidine;acetyl-CoA + D-norvaline = CoA + N-acetyl-D-norvaline;acetyl-CoA + D-serine = CoA + N-acetyl-D-serine;acetyl-CoA + D-cystine = CoA + N-acetyl-D-cystine;acetyl-CoA + D-isoleucine = CoA + N-acetyl-D-isoleucine;acetyl-CoA + norleucine = CoA + N-acetyl-D-norleucine;acetyl-CoA + D-proline = CoA + N-acetyl-D-proline;acetyl-CoA + D-methionine = CoA + N-acetyl-D-methionine;propionyl-CoA + D-leucine = CoA + N-propionyl-D-leucine;propionyl-CoA + D-glutamine = CoA + N-propionyl-D-glutamine;propionyl-CoA + D-allo-isoleucine = CoA + N-propionyl-D-allo-isoleucine;propionyl-CoA + D-serine = CoA + N-propionyl-D-serine;propionyl-CoA + D-tryptophan = CoA + N2-propionyl-D-tryptophan;Acetyl-CoA + Histone-L-lysine <=> CoA + Histone N6-acetyl-L-lysine;acetyl-CoA + [histone]-L-lysine = [histone]-N6-acetyl-L-lysine + coenzyme A + H+;acetyl-CoA + histone H4 = CoA + acetylhistone H4;4 acetyl-CoA + histone H4 = 4 CoA + tetraacetylhistone H4;histone H4 + acetyl-CoA = acetyl-histone H4 + CoA;acetyl-CoA + p53 = CoA + acetyl-p53;histone H3 + acetyl-CoA = acetyl-histone H3 + CoA;acetyl-CoA + histone H3 = CoA + acetylhistone H3;acetyl-CoA + histone H2A = CoA + acetylhistone H2A;piccoloNuA4 peptide + acetyl-CoA = acetyl-piccoloNuA4 peptide + CoA;acetyl-CoA + c-Myc = CoA + acetylated c-Myc;androgen receptor + acetyl-CoA = acetylated androgen receptor + CoA;acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine;acetyl-CoA + histone H = CoA + acetylhistone H;ATM kinase + acetyl-CoA = acetylated ATM kinase + CoA;promyelotic leukemia zinc finger gene + acetyl-CoA = acetylated promyelotic leukemia zinc finger gene + CoA;acetyl-CoA + beta-site amyloid precursor protein-cleaving enzyme 1 = CoA + acetylated beta-site amyloid precursor protein-cleaving enzyme 1;acetyl-CoA + p50 protein = CoA + acetyl-p50 protein;acetyl-CoA + p65 protein = CoA + acetyl-p65 protein;acetyl-CoA + histone = CoA + acetylhistone" Acetyl-CoA + D-Phenylalanine <=> CoA + N-Acetyl-D-phenylalanine 5 out of 5 "Acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid. {ECO:0000269|PubMed:15375647}.; Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine. {ECO:0000269|PubMed:23775086}." "Acetyl-CoA + a D-amino acid <=> CoA + an N-acetyl-D-amino acid; Acetyl-CoA + [protein]-L-lysine <=> CoA + [protein]-N(6)-acetyl-L-lysine" YES other pathway from kegg "NA;NA" Phenylalanine metabolism "Phenylalanine metabolism;path:map00360;NA" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -109 YEL070W "Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication" Mannitol dehydrogenase 1.1.1.- Mannitol dehydrogenase DSF1 (EC 1.1.1.-) (Deletion suppressor of MPT5 mutation protein 1) "DSF1, MAN1; mannitol dehydrogenase DSF1" 1.1.1.67 Deletion Suppressor of mptFive/pufFive mutation Mannitol + NAD+ <=> D-Fructose + NADH + H+ 2 out of 5 NA Mannitol + NAD+ <=> D-Fructose + NADH + H+ YES Fructose and mannose metabolism pathway from kegg "E646;E743;H1286" Fructose and mannose metabolism NA -110 YER001W "Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family" 2.4.1.- Alpha-1,3-mannosyltransferase Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications. 2.4.1.- Alpha-1,3-mannosyltransferase MNN1 (EC 2.4.1.-) "MNN1; alpha-1,3-mannosyltransferase MNN1" "α-1,3-mannosyltransferase MMN1" GDP-alpha-D-mannose + an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] => an alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] + GDP + H+ "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" 4 out of 5 NA "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" YES Various types of N-glycan biosynthesis pathway from kegg "H815;H837;H838;H839" "PATHWAY: Protein modification; protein glycosylation." "Various types of N-glycan biosynthesis;Other types of O-glycan biosynthesis;Metabolic pathways" protein O-mannosylation I (yeast) NA Golgi membrane "Golgi membrane;Golgi" Golgi membrane -111 YER010C "Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate" "4.1.1.3;4.1.3.17" Bifunctional HMG aldolase/oxaloacetate decarboxylase Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions. {ECO:0000269|PubMed:24359411}. "4.1.3.17; 4.1.1.3" 4-hydroxy-4-methyl-2-oxoglutarate aldolase (HMG aldolase) (EC 4.1.3.17) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.3) (Regulator of ribonuclease activity homolog) (RraA-like protein) bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase Unknown "NA;4-hydroxy-4-methyl-2-oxoglutarate => 2 pyruvate;2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate;2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => oxaloacetate + pyruvate;oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate" "oxaloacetate = pyruvate + CO2;2-Oxobutanoate + CO2 <=> Methyloxaloacetate;4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate;4-carboxy-4-hydroxy-2-oxoadipate = oxaloacetate + pyruvate;(R)-4-hydroxy-4-methyl-2-oxoglutarate = pyruvate;l-4-carboxy-4-hydroxy-2-oxoadipate = pyruvate + oxaloacetate" "4-hydroxy-4-methyl-2-oxoglutarate => 2 pyruvate;2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate;2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => oxaloacetate + pyruvate;oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate;NA" "4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate;4-carboxy-4-hydroxy-2-oxoadipate = oxaloacetate + pyruvate;(R)-4-hydroxy-4-methyl-2-oxoglutarate = pyruvate;l-4-carboxy-4-hydroxy-2-oxoadipate = pyruvate + oxaloacetate;oxaloacetate = pyruvate + CO2;2-Oxobutanoate + CO2 <=> Methyloxaloacetate" 5 out of 5 "4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. {ECO:0000269|PubMed:24359411}.; Oxaloacetate = pyruvate + CO(2). {ECO:0000269|PubMed:24359411}." "4-hydroxy-4-methyl-2-oxoglutarate <=> 2 pyruvate; Oxaloacetate <=> pyruvate + CO2" YES "Benzoate degradation; C5-Branched dibasic acid metabolism" pathway from kegg "NA;NA" "Benzoate degradation;path:map00362;C5-Branched dibasic acid metabolism;path:map00660;Microbial metabolism in diverse environments;path:map01120;NA" -116 YER042W "Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease" 1.8.4.11 Methionine-S-sulfoxide reductase Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product. 1.8.4.11 Peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) "MXR1; peptide-methionine-S-sulfoxide reductase" 1.8.4.11 peptide methionine sulfoxide reductase MSRA reduces L-methyl-(S)-S-oxide to L-Methionine "[protein]-L-methionine + [thioredoxin]-disulfide + H2O => [protein]-L-methionine (S)-S-oxide + [thioredoxin]-dithiol;[protein]-L-methionine (S)-S-oxide + [thioredoxin]-dithiol => [protein]-L-methionine + [thioredoxin]-disulfide + H2O" "L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine (S)-S-oxide + Thioredoxin;Peptide-L-methionine + Thioredoxin disulfide + H2O <=> Peptide-L-methionine (S)-S-oxide + Thioredoxin;[protein]-L-methionine + oxidized thioredoxin + H2O = protein-L-methionine-(S)-S-oxide + reduced thioredoxin;calmodulin L-methionine-(S)-sulfoxide + thioredoxin = calmodulin L-methionine + thioredoxin disulfide;dabsyl-L-methionine (S)-sulfoxide + thioredoxin = dabsyl-L-methionine + thioredoxin disulfide + H2O;sulindac + thioredoxin = sulindac sulfide + thioredoxin disulfide + H2O;Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + thioredoxin = Tyr-Gly-Gly-Phe-L-methionine + thioredoxin disulfide + H2O;ribosomal protein L12-L-methionine (S)-sulfoxide + thioredoxin = ribosomal protein L12-L-methionine + thioredoxin disulfide + H2O;peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin;protein-L-methionine (S)-sulfoxide + thioredoxin = protein-L-methionine + thioredoxin disulfide + H2O;Hsp21 L-methionine S-oxide + dithiothreitol = Hsp21 L-methionine + dithiothreitol S-oxide;L-methionine (S)-sulfoxide + 2 dithiothreitol = L-methionine + dithiothreitol disulfide + H2O;L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O" "[protein]-L-methionine + [thioredoxin]-disulfide + H2O => [protein]-L-methionine (S)-S-oxide + [thioredoxin]-dithiol;[protein]-L-methionine (S)-S-oxide + [thioredoxin]-dithiol => [protein]-L-methionine + [thioredoxin]-disulfide + H2O" "L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine (S)-S-oxide + Thioredoxin;Peptide-L-methionine + Thioredoxin disulfide + H2O <=> Peptide-L-methionine (S)-S-oxide + Thioredoxin;[protein]-L-methionine + oxidized thioredoxin + H2O = protein-L-methionine-(S)-S-oxide + reduced thioredoxin;calmodulin L-methionine-(S)-sulfoxide + thioredoxin = calmodulin L-methionine + thioredoxin disulfide;dabsyl-L-methionine (S)-sulfoxide + thioredoxin = dabsyl-L-methionine + thioredoxin disulfide + H2O;sulindac + thioredoxin = sulindac sulfide + thioredoxin disulfide + H2O;Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + thioredoxin = Tyr-Gly-Gly-Phe-L-methionine + thioredoxin disulfide + H2O;ribosomal protein L12-L-methionine (S)-sulfoxide + thioredoxin = ribosomal protein L12-L-methionine + thioredoxin disulfide + H2O;peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin;protein-L-methionine (S)-sulfoxide + thioredoxin = protein-L-methionine + thioredoxin disulfide + H2O;Hsp21 L-methionine S-oxide + dithiothreitol = Hsp21 L-methionine + dithiothreitol S-oxide;L-methionine (S)-sulfoxide + 2 dithiothreitol = L-methionine + dithiothreitol disulfide + H2O;L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O" "a [protein]-L-methionine + an oxidized thioredoxin + H2O = a protein-L-methionine-(R)-S-oxide + a reduced thioredoxin;a [protein]-L-methionine + an oxidized thioredoxin + H2O = a protein-L-methionine-(S)-S-oxide + a reduced thioredoxin" 3 out of 5 "Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin; L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin." L-methionine + thioredoxin disulfide + H(2)O <=> L-methionine (S)-S-oxide + thioredoxin YES Cysteine and methionine metabolism "L-methionine-S-oxide reductase; [c] : metsox-S-L + trdrd --> h2o + met-L + trdox; Methionine Metabolism from e.coli model; it was changed into Cysteine and methionine metabolism based on yeast7.7" "E526;H1252" Protein repair NA "nucleus;cytoplasm" -120 YER087W "Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss" 6.1.1.15 Protein with similarity to tRNA synthetases 6.1.1.15 Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Altered inheritance rate of mitochondria protein 10) (Prolyl-tRNA synthetase) (ProRS) "AIM10; putative proline--tRNA ligase AIM10" 6.1.1.15 Altered Inheritance rate of Mitochondria "L-proline + ATP + tRNA(Pro) => L-prolyl-tRNA(Pro) + AMP + diphosphate;L-prolyl-tRNA(Pro) + AMP + diphosphate => L-proline + ATP + tRNA(Pro)" "ATP + L-Proline + tRNA(Pro) <=> AMP + Diphosphate + L-Prolyl-tRNA(Pro);tRNApro + L-proline + ATP = L-prolyl-[tRNApro] + diphosphate + AMP;ATP + L-proline + tRNAPro = AMP + diphosphate + L-prolyl-tRNAPro;ATP + L-cysteine + tRNAPro = AMP + diphosphate + L-cysteinyl-tRNAPro" "L-proline + ATP + tRNA(Pro) => L-prolyl-tRNA(Pro) + AMP + diphosphate;L-prolyl-tRNA(Pro) + AMP + diphosphate => L-proline + ATP + tRNA(Pro)" "ATP + L-Proline + tRNA(Pro) <=> AMP + Diphosphate + L-Prolyl-tRNA(Pro);tRNApro + L-proline + ATP = L-prolyl-[tRNApro] + diphosphate + AMP;ATP + L-proline + tRNAPro = AMP + diphosphate + L-prolyl-tRNAPro;ATP + L-cysteine + tRNAPro = AMP + diphosphate + L-cysteinyl-tRNAPro" a tRNApro + L-proline + ATP => an L-prolyl-[tRNApro] + AMP + diphosphate ATP + L-Proline + tRNA(Pro) <=> AMP + Diphosphate + L-Prolyl-tRNA(Pro) 3 out of 5 ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). L-proline + ATP + tRNA(Pro) <=> L-prolyl-tRNA(Pro) + AMP + diphosphate YES Aminoacyl-tRNA biosynthesis "pathway from kegg; reaction from rhea" H1017 Aminoacyl-tRNA biosynthesis tRNA charging "Aminoacyl-tRNA biosynthesis;path:map00970" mitochondrion "cytoplasm;mitochondrion" mitochondrion -132 YER141W "Protein required for the hydroxylation of heme O to form heme A; heme A is an essential prosthetic group for cytochrome c oxidase" Protein required for the hydroxylation of heme O to form heme A Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase. {ECO:0000269|PubMed:11248251, ECO:0000269|PubMed:9228094}. Cytochrome c oxidase assembly protein COX15 "COX15; Cox15p" heme a synthase COX15 transforms heme O to heme A ferroheme o + 2 a reduced electron acceptor + 2 oxygen => ferroheme a + 2 an oxidized electron acceptor + 3 H2O Heme O <=> Heme A COX15 transforms heme O to heme A 3 out of 5 NA Heme O <=> Heme A YES Porphyrin and chlorophyll metabolism pathway from kegg "Oxidative phosphorylation;Porphyrin and chlorophyll metabolism;Metabolic pathways;Biosynthesis of secondary metabolites" heme a biosynthesis Heme biosynthesis NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -136 YER163C "Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle" 2.3.2.- Gamma-glutamyl cyclotransferase Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Allows utilization of gluthathione through subsequent cleavage of the Cys-Gly dipeptide by Cys-Gly metallodipeptidase DUG1. {ECO:0000269|PubMed:23070364}. 4.3.2.- Glutathione-specific gamma-glutamylcyclotransferase (Gamma-GCG) (EC 4.3.2.-) "GCG1; gamma-glutamylcyclotransferase" glutathione-specific gamma-glutamylcyclotransferase "CHAC1,2 cleaves GSH to OPRO and CysGly;CHAC1,2 cleaves GSH to OPRO and CysGly" "CHAC1,2 cleaves GSH to OPRO and CysGly;CHAC1,2 cleaves GSH to OPRO and CysGly" 4 out of 5 Glutathione = 5-oxo-L-proline + L-cysteinylglycine. {ECO:0000269|PubMed:23070364}. Glutathione <=> 5-oxo-L-proline + L-cysteinylglycine YES Glutathione metabolism "Glutathione = 5-oxo-L-proline + L-cysteinylglycine; pathway from reactome;. It is changed into Glutathione metabolism" 5-oxo-L-proline metabolism Glutathione synthesis and recycling NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -137 YER166W "Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog, DNF2, that arose from the whole genome duplication" 3.6.3.1 Aminophospholipid translocase (flippase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. {ECO:0000305}. 3.6.3.1 Phospholipid-transporting ATPase DNF1 (EC 3.6.3.1) (Flippase DNF1) "DNF1; aminophospholipid-translocating P4-type ATPase DNF1" 3.6.3.1 Drs2 Neo1 Family "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ YES phospholipids transport pathway from reactome "E586;H449" Ion transport by P-type ATPases NA "cell envelope;cytoplasm;Golgi" "Golgi membrane;mitochondrion;cytoplasm;endoplasmic reticulum;Golgi;cell envelope" "cell envelope;Golgi;cytoplasm" -144 YHL012W "Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication" 2.7.7.9 Putative UTP glucose-1-phosphate uridylyltransferase Plays a central role as a glucosyl donor in cellular metabolic pathways. {ECO:0000250}. 2.7.7.9 Probable UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) UTP--glucose-1-phosphate uridylyltransferase 2.7.7.9 UTP glucose-1-phosphate uridylyltransferase "alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-D-glucose;diphosphate + UDP-D-glucose => alpha-D-glucose 1-phosphate + H(+) + UTP" "UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-alpha-D-galactose;dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose;UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose" "alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-D-glucose;diphosphate + UDP-D-glucose => alpha-D-glucose 1-phosphate + H(+) + UTP" "UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-alpha-D-galactose;dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose;UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose" alpha-D-glucopyranose 1-phosphate + UTP + H+ <=> UDP-alpha-D-glucose + diphosphate UTP + D-Glucose 1-phosphate <=> Diphosphate + UDP-glucose 2 out of 5 UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose. UTP + D-Glucose 1-phosphate <=> Diphosphate + UDP-glucose YES Pentose and glucuronate interconversions pathway from kegg "E341;H733" "dolichyl glucosyl phosphate biosynthesis;glycogen biosynthesis" "Pentose and glucuronate interconversions;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of antibiotics" dolichyl glucosyl phosphate biosynthesis // UDP-glucose biosynthesis "Pentose and glucuronate interconversions;path:map00040;Galactose metabolism;path:map00052;Starch and sucrose metabolism;path:map00500;Amino sugar and nucleotide sugar metabolism;path:map00520;Metabolic pathways;path:map01100;Biosynthesis of antibiotics;path:map01130" cytoplasm -145 YHL018W "Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS" 4.2.1.96 Putative 4a-hydroxytetrahydrobiopterin dehydratase 4.2.1.96 Putative pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydratase) (PCD) 4A-hydroxytetrahydrobiopterin dehydratase 4.2.1.96 Unknown "4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O;(6R)-L-erythro-6,7-dihydrobiopterin + H2O => 4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin" "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O;10-formyltetrahydrofolate-4a-carbinolamine = 10-formyldihydrofolate + H2O;4alpha-hydroxy-tetrahydrobiopterin = 7,8-dihydrobiopterin + H2O" "4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O;(6R)-L-erythro-6,7-dihydrobiopterin + H2O => 4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin" "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O;10-formyltetrahydrofolate-4a-carbinolamine = 10-formyldihydrofolate + H2O;4alpha-hydroxy-tetrahydrobiopterin = 7,8-dihydrobiopterin + H2O" "4alpha-hydroxy-tetrahydrobiopterin = 7,8-dihydrobiopterin + H2O;a 10-formyltetrahydrofolate-4a-carbinolamine = an N10-formyldihydrofolate + H2O" 4a-Hydroxytetrahydrobiopterin <=> Dihydrobiopterin + H2O 2 out of 5 (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O. 4a-Hydroxytetrahydrobiopterin <=> Dihydrobiopterin + H2O YES Folate biosynthesis pathway from kegg H552 Folate biosynthesis "Folate biosynthesis;path:map00790" mitochondrion -148 YHR001W "Oxysterol-binding protein; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication" NA Oxysterol-binding protein Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. {ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206936}. NA Oxysterol-binding protein homolog 7 "OSH7; oxysterol-binding protein related protein OSH7" NA oxysterol-binding protein homolog 7 "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" NA NA NA NA NA NA "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" 5 out of 5 NA "phosphatidylserine <=> phosphatidylserine; phosphatidylinositol 4-phosphate <=> phosphatidylinositol 4-phosphate" YES Lipid transport "Lipid transporter; deliver ps from ER membrane to plasma membrane for the exchanges of phosphatidylinositol 4-phosphate; phosphatidylserine[er] + phosphatidylinositol 4-phosphate[c] => phosphatidylserine[c] + phosphatidylinositol 4-phosphate[er]" NA NA NA NA NA "Acyl chain remodelling of PS;Synthesis of bile acids and bile salts" NA endoplasmic reticulum membrane "cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -150 YHR008C "Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix" 1.15.1.1 Mitochondrial manganese superoxide dismutase Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. 1.15.1.1 Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) "SOD2; superoxide dismutase SOD2" 1.15.1.1 mitochondrial superoxide dismutase "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix);SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2;SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2" "2 H(+) + 2 superoxide => H2O2 + O2;H2O2 + O2 => 2 H(+) + 2 superoxide" 2 superoxide + 2 H+ = O2 + H2O2 "2 H(+) + 2 superoxide => H2O2 + O2;H2O2 + O2 => 2 H(+) + 2 superoxide" 2 superoxide + 2 H+ = O2 + H2O2 2 superoxide + 2 H+ => hydrogen peroxide + oxygen 5 out of 5 2 superoxide + 2 H(+) = O(2) + H(2)O(2). 2 H(+) + 2 superoxide <=> H2O2 + O2 YES Peroxisome "pathway from kegg; reaction from rhea" "E398;H537" removal of superoxide radicals "Peroxisome;Longevity regulating pathway - multiple species" superoxide radicals degradation // ethylene biosynthesis "Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species" NA mitochondrion mitochondrion mitochondrion -156 YHR043C "2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae" 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase Active on 2-DOG-6P, not very active on fructose-1p. 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase 2 (2-DOG-6-P 2) (2-deoxyglucose-6-phosphatase 2) (EC 3.1.3.68) "DOG2; 2-deoxyglucose-6-phosphatase" 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate;2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O" "2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate" "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate;2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O" "2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate" 2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate 3 out of 5 2-deoxy-D-glucose 6-phosphate + H(2)O = 2-deoxy-D-glucose + phosphate. 2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate YES Alternate Carbon Metabolism pathway from e.coli model E695 NA "nucleus;cytoplasm" -157 YHR044C "2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae" 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase Active on 2-DOG-6P, also very active on fructose-1P. 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase 1 (2-DOG-6-P 1) (2-deoxyglucose-6-phosphatase 1) (EC 3.1.3.68) "DOG1; 2-deoxyglucose-6-phosphatase" 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate;2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O" "2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate" "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate;2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O" "2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate" 2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate 3 out of 5 2-deoxy-D-glucose 6-phosphate + H(2)O = 2-deoxy-D-glucose + phosphate. 2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate YES Alternate Carbon Metabolism pathway from e.coli model E695 NA cytoplasm -167 YHR109W "Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth" 2.1.1.59 Cytochrome c lysine methyltransferase Methyltransferase which mediates trimethylation of 'Lys-78' of cytochrome c (CYC1). {ECO:0000269|PubMed:10791961}. 2.1.1.59 Cytochrome c lysine N-methyltransferase 1 (EC 2.1.1.59) "CTM1; cytochrome c lysine N-methyltransferase" 2.1.1.59 cytochrome c methyltransferase "S-adenosyl-L-methionine + [cytochrome c]-L-lysine => S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [cytochrome c]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[cytochrome c]-L-lysine + S-adenosyl-L-methionine = [cytochrome c]-N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+;S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine" "S-adenosyl-L-methionine + [cytochrome c]-L-lysine => S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [cytochrome c]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[cytochrome c]-L-lysine + S-adenosyl-L-methionine = [cytochrome c]-N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+;S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine" a [cytochrome c]-L-lysine + S-adenosyl-L-methionine => a [cytochrome c]-N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+ "Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine" 4 out of 5 S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine. {ECO:0000255|PROSITE-ProRule:PRU00943, ECO:0000269|PubMed:10791961}. S-adenosyl-L-methionine + [cytochrome c]-L-lysine <=> S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine YES Lysine metabolism "pathway from kegg; reaction from uniprot; Lysine degradation was changed into lysine metabolism based on yeast 7.7" Lysine degradation "Lysine degradation;path:map00310" cytoplasm cytoplasm cytoplasm -171 YHR116W "Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs" NA Protein that functions in mitochondrial copper homeostasis Required for the assembly of cytochrome c oxidase. {ECO:0000269|PubMed:15145942}. NA Cytochrome c oxidase-assembly factor COX23, mitochondrial "COX23; Cox23p" NA Cytochrome OXidase NA NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 3 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA NA aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA "cytoplasm;mitochondrial membrane" "cytoplasm;mitochondrion;mitochondrial membrane" "mitochondrial membrane;cytoplasm" -172 YHR119W "Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain" 2.1.1.43 Histone methyltransferase, subunit of the COMPASS (Set1C) complex Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. {ECO:0000269|PubMed:11742990, ECO:0000269|PubMed:11751634, ECO:0000269|PubMed:11752412, ECO:0000269|PubMed:11805083, ECO:0000269|PubMed:11818070, ECO:0000269|PubMed:12060701, ECO:0000269|PubMed:12353038, ECO:0000269|PubMed:12845608, ECO:0000269|PubMed:14636589, ECO:0000269|PubMed:15949446, ECO:0000269|PubMed:9398665, ECO:0000269|PubMed:9988274}. 2.1.1.43 Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC 2.1.1.43) (COMPASS component SET1) (Lysine N-methyltransferase 2) (SET domain-containing protein 1) "SET1, KMT2, YTX1; histone methyltransferase SET1" 2.1.1.43 SET domain-containing SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" a [histone]-L-lysine + S-adenosyl-L-methionine => a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+ "Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine;S-Adenosyl-L-methionine + Histone-L-lysine <=> S-Adenosyl-L-homocysteine + Histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine" 5 out of 5 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. {ECO:0000269|PubMed:11805083}. S-adenosyl-L-methionine + L-lysine-[histone] <=> S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone] YES Lysine metabolism "pathway from kegg; reaction from uniprot; Lysine degradation was changed into lysine metabolism based on yeast 7.7" "H372;H974" Lysine degradation PKMTs methylate histone lysines "Lysine degradation;path:map00310" nucleus nucleus nucleus -174 YHR143W-A "RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress" RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) "RPC10, RPB12; DNA-directed RNA polymerase core subunit RPC10" RNA Polymerase C "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Binding of RRN3 to RNA Polymerase I;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase I Transcription Initiation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus "nucleus;cytoplasm" nucleus -179 YHR179W "Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress" 1.6.99.1 Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) Oxidizes beta-NADH, beta-NADPH, and alpha-NADPH. 1.6.99.1 NADPH dehydrogenase 2 (EC 1.6.99.1) (Old yellow enzyme 2) "OYE2; NADPH dehydrogenase" 1.6.99.1 NAPDH dehydrogenase "NADPH + H+ + acceptor = NADP+ + reduced acceptor;2-cyclohexen-1-one + NADPH + H+ = cyclohexanone + NADP+" "NADPH + H+ + acceptor = NADP+ + reduced acceptor;2-cyclohexen-1-one + NADPH + H+ = cyclohexanone + NADP+" an oxidized electron acceptor + NADPH + H+ = a reduced electron acceptor + NADP+ Acceptor + NADPH + H+ <=> Reduced acceptor + NADP+ 5 out of 5 NADPH + acceptor = NADP(+) + reduced acceptor. Acceptor + NADPH + H+ <=> Reduced acceptor + NADP+ YES other no pathway from database NA "nucleus;cytoplasm;mitochondrion" -180 YHR189W "One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2" 3.1.1.29 One of two mitochondrially-localized peptidyl-tRNA hydrolases 3.1.1.29 Peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29) "PTH1; aminoacyl-tRNA hydrolase" 3.1.1.29 Peptidyl-Trna Hydrolase "N-acyl-L-alpha-aminoacyl-tRNA + H2O => an N-acyl-L-amino acid + H(+) + tRNA;an N-acyl-L-amino acid + H(+) + tRNA => N-acyl-L-alpha-aminoacyl-tRNA + H2O" "N-Substituted aminoacyl-tRNA + H2O <=> N-Substituted amino acid + tRNA;H2O + N-modified aminoacyl-[tRNA] = uncharged tRNA + N-modified amino acid + H+;L-asparaginyl-[tRNAasn] + H2O = L-asparagine + tRNAasn + H+;L-cysteinyl-[tRNAcys] + H2O = L-cysteine + tRNAcys + H+;N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA;diacetyl-lysyl-tRNALys + H2O = diacetyl-lysine + tRNALys;peptidyl-tRNAL + H2O = peptide + tRNA;peptidyl-tRNALys + H2O = peptide + tRNALys;peptidyl-tRNA + H2O = peptide + tRNA" "N-acyl-L-alpha-aminoacyl-tRNA + H2O => an N-acyl-L-amino acid + H(+) + tRNA;an N-acyl-L-amino acid + H(+) + tRNA => N-acyl-L-alpha-aminoacyl-tRNA + H2O" "N-Substituted aminoacyl-tRNA + H2O <=> N-Substituted amino acid + tRNA;H2O + N-modified aminoacyl-[tRNA] = uncharged tRNA + N-modified amino acid + H+;L-asparaginyl-[tRNAasn] + H2O = L-asparagine + tRNAasn + H+;L-cysteinyl-[tRNAcys] + H2O = L-cysteine + tRNAcys + H+;N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA;diacetyl-lysyl-tRNALys + H2O = diacetyl-lysine + tRNALys;peptidyl-tRNAL + H2O = peptide + tRNA;peptidyl-tRNALys + H2O = peptide + tRNALys;peptidyl-tRNA + H2O = peptide + tRNA" "an L-asparaginyl-[tRNAasn] + H2O => L-asparagine + tRNAasn + H+;an N-modified aminoacyl-[tRNA] + H2O => an uncharged tRNA + an N-modified amino acid + H+" 2 out of 5 N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA. N-acyl-L-alpha-aminoacyl-tRNA + H2O <=> an N-acyl-L-amino acid + H(+) + tRNA YES other "no pathway from database; reaction from rhea" H1234 NA mitochondrion mitochondrion mitochondrion -181 YHR201C "Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix" 3.6.1.11 Exopolyphosphatase Degradation of inorganic polyphosphates. 3.6.1.11 Exopolyphosphatase (ExopolyPase) (EC 3.6.1.11) (Metaphosphatase) "PPX1; exopolyphosphatase" 3.6.1.11 exopolyphosphatase "H2O + polyphosphaten => H(+) + phosphate + polyphosphaten-1;H(+) + phosphate + polyphosphaten-1 => H2O + polyphosphaten" "(polyphosphate)n + H2O = (polyphosphate)n-1 + phosphate;guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;inosine tetraphosphate + H2O = ITP + phosphate" "H2O + polyphosphaten => H(+) + phosphate + polyphosphaten-1;H(+) + phosphate + polyphosphaten-1 => H2O + polyphosphaten" "(polyphosphate)n + H2O = (polyphosphate)n-1 + phosphate;guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;inosine tetraphosphate + H2O = ITP + phosphate" (polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate Guanosine 3'-diphosphate 5'-triphosphate + H2O <=> Guanosine 3',5'-bis(diphosphate) + Orthophosphate 4 out of 5 (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate. (polyphosphate)(n) + H2O <=> (polyphosphate)(n-1) + phosphate YES Cofactor and Prosthetic Group Biosynthesis "pathway in kegg is wrong; pathway from e.coli model" E590 Purine metabolism "Purine metabolism;path:map00230" "cytoplasm;mitochondrion;cell envelope" -185 YIL014W "Alpha-1,3-mannosyltransferase; adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation" 2.4.1.- Alpha-1,3-mannosyltransferase Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans. 2.4.1.- Alpha-1,3-mannosyltransferase MNT3 (EC 2.4.1.-) "MNT3; alpha-1,3-mannosyltransferase MNT3" "α-1,3-mannosyltransferase MMN3" "GDP-alpha-D-mannose + an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] => an alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] + GDP + H+;GDP-alpha-D-mannose + an alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] => an alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] + GDP + H+" "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" 3 out of 5 NA "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" YES Other types of O-glycan biosynthesis pathway from kegg "H815;H837;H838;H839" "PATHWAY: Protein modification; protein glycosylation." Other types of O-glycan biosynthesis protein O-mannosylation I (yeast) NA Golgi membrane "Golgi membrane;vacuole;Golgi" Golgi membrane -187 YIL021W "RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit" RNA polymerase II third largest subunit B44 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination. {ECO:0000269|PubMed:16537912}. DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (B44.5) (DNA-directed RNA polymerase II 45 kDa polypeptide) "RPB3; DNA-directed RNA polymerase II core subunit RPB3" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus -188 YIL023C "Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family" Zinc transporter Zinc transporter whose role depends on the zinc status of the cells. It helps to balance zinc levels between the cytosol and the secretory pathway. It transports zinc into the secretory pathway in a zinc-adequate environment and in a high zinc medium. In high zinc medium, transport of zinc into the secretory pathway is a way to eliminate zinc from the cytosol. Under low cytosolic zinc conditions, it removes zinc from the secretory pathway and acts as zinc importer that helps to alleviate ER stress. {ECO:0000269|PubMed:16760462}. Zinc transporter YKE4 "YKE4; Zn(2+) transporter YKE4" Yeast ortholog of mouse KE4 "ZIP6 and ZIP14 mediate zinc influx into cells;ZIP6 and ZIP14 mediate zinc influx into cells;ZIP8 mediates zinc influx into cells;ZIP7 mediates zinc efflux from the endoplasmic reticulum;SLC39A1-4 transports Zn2+ from extracellular region to cytosol" "ZIP6 and ZIP14 mediate zinc influx into cells;ZIP6 and ZIP14 mediate zinc influx into cells;ZIP8 mediates zinc influx into cells;ZIP7 mediates zinc efflux from the endoplasmic reticulum;SLC39A1-4 transports Zn2+ from extracellular region to cytosol" 3 out of 5 NA Zn2+ <=> Zn2+ YES Zinc transport Zinc tranport Zinc influx into cells by the SLC39 gene family NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -193 YIL043C "Cytochrome b reductase; not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia" 1.6.2.2 Cytochrome b reductase Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes. Plays a role in bud morphology. {ECO:0000269|PubMed:10622712}. 1.6.2.2 NADH-cytochrome b5 reductase 1 (EC 1.6.2.2) (Microsomal cytochrome b reductase) (P35) "CBR1, CBR5; Cbr1p" 1.6.2.2 NADH-cytochrome b5 reductase "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme;Surface deployment of platelet alpha granule membrane components;Surface deployment of platelet alpha granule membrane components;Exocytosis of azurophil granule lumen proteins;Exocytosis of azurophil granule lumen proteins;CYB5Rs reduce MetHb to Hb;CYB5Rs reduce MetHb to Hb" "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" 2 a ferricytochrome b5 + NADH => 2 a ferrocytochrome b5 + NAD+ + H+ NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme;CYB5Rs reduce MetHb to Hb;CYB5Rs reduce MetHb to Hb" 5 out of 5 NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5. NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ YES Amino sugar and nucleotide sugar metabolism pathway from kegg H588 Amino sugar and nucleotide sugar metabolism "Platelet degranulation ;Erythrocytes take up carbon dioxide and release oxygen;Vitamin C (ascorbate) metabolism;Neutrophil degranulation" "Amino sugar and nucleotide sugar metabolism;path:map00520" "endoplasmic reticulum membrane;mitochondrial membrane" "nucleus;mitochondrion;mitochondrial membrane;endoplasmic reticulum;endoplasmic reticulum membrane" "mitochondrial membrane;endoplasmic reticulum membrane" -194 YIL048W "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ YES phospholipids transport "E586;H449" NA "cytoplasm;Golgi membrane" "Golgi membrane;cytoplasm;Golgi;cell envelope" "Golgi membrane;cytoplasm" -195 YIL049W "Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human homolog SRD5A3 confer CDG (Congenital Disorders of Glycosylation); human SRD5A3 can complement yeast null mutant" 1.3.1.94 Probable polyprenol reductase Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. {ECO:0000269|PubMed:20637498}. 1.3.1.94 Polyprenol reductase (EC 1.3.1.94) (Protein DFG10) "DFG10; putative polyprenol reductase" "1.3.1.22;1.3.1.94" polyprenol reductase "di-trans,poly-cis-dolichol + NADP(+) => di-trans,poly-cis-polyprenol + H(+) + NADPH;di-trans,poly-cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)" ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH + H+ "di-trans,poly-cis-dolichol + NADP(+) => di-trans,poly-cis-polyprenol + H(+) + NADPH;di-trans,poly-cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)" ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH + H+ a di-trans, poly-cis-polyprenol + NADPH + H+ => a dolichol + NADP+ "5alpha-Pregnane-3,20-dione + NADP+ <=> Progesterone + NADPH + H+;Dihydrotestosterone + NADP+ <=> Testosterone + NADPH + H+;11-Deoxycorticosterone + NADPH + H+ <=> 5alpha-Dihydrodeoxycorticosterone + NADP+;5alpha-Androstane-3,17-dione + NADP+ <=> Androstenedione + NADPH + H+" 5 out of 5 Ditrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH. {ECO:0000269|PubMed:20637498}. a di-trans, poly-cis-polyprenol + NADPH + H+ => a dolichol + NADP+ YES dolichol and dolichyl phosphate biosynthesis pathway from biocyc "PATHWAY: Protein modification; protein glycosylation." dolichol and dolichyl phosphate biosynthesis NA endoplasmic reticulum membrane "cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -211 YIR008C "Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair" 2.7.7.- Subunit of DNA primase DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48. 2.7.7.- DNA primase small subunit (EC 2.7.7.-) (DNA polymerase alpha:primase complex p48 subunit) (DNA polymerase-primase complex p48 subunit) (Pol alpha-primase complex p48 subunit) (DNA primase 48 kDa subunit) "PRI1; DNA primase subunit PRI1" NA DNA PRImase "Detection of damage during initiation of DNA synthesis in S-phase;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere;RFC binding displaces Pol Alpha on the C-strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin;RFC binding displaces Pol Alpha;Loading of PCNA - Sliding Clamp Formation;RFC dissociates after sliding clamp formation;Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" NA NA NA NA a single stranded DNA = a short RNA Segment "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" NA 5 out of 5 NA 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA primase is required for DNA synthesis and double-strand break repair NA NA NA "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication" NA "Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand" NA nucleus -216 YIR036C "Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci" 1.1.1.320 Putative benzil reductase Reduces benzil stereospecifically to (S)-benzoin. Is probably involved in a pathway contributing to genomic integrity. 1.1.1.320 Benzil reductase ((S)-benzoin forming) IRC24 (EC 1.1.1.320) (Increased recombination centers protein 24) "IRC24; sepiapterin reductase family protein IRC24" 1.1.1.320 Increased Recombination Centers "PTHP is reduced to BH4 by sepiapterin reductase (SPR);Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II;Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II;Salvage - Sepiapterin is reduced to BH2" "(S)-benzoin + NADP(+) => benzil + H(+) + NADPH;benzil + H(+) + NADPH => (S)-benzoin + NADP(+);2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH;1-phenyl-1,2-propanedione + H(+) + NADPH => 2-hydroxy-1-phenyl-1-propanone + NADP(+)" "(S)-benzoin + NADP+ = benzil + NADPH + H+;2-hydroxy-1-phenyl-1-propanone + NADP+ = 1-phenylpropane-1,2-dione + NADPH + H+" "(S)-benzoin + NADP(+) => benzil + H(+) + NADPH;benzil + H(+) + NADPH => (S)-benzoin + NADP(+);2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH;1-phenyl-1,2-propanedione + H(+) + NADPH => 2-hydroxy-1-phenyl-1-propanone + NADP(+)" "(S)-benzoin + NADP+ = benzil + NADPH + H+;2-hydroxy-1-phenyl-1-propanone + NADP+ = 1-phenylpropane-1,2-dione + NADPH + H+" NA NA "PTHP is reduced to BH4 by sepiapterin reductase (SPR);Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II;Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II;Salvage - Sepiapterin is reduced to BH2" 4 out of 5 (S)-benzoin + NADP(+) = benzil + NADPH. {ECO:0000269|PubMed:11796169}. (S)-benzoin + NADP(+) = benzil + NADPH YES Other NA NA NA NA NA NA Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation NA cytoplasm -217 YIR038C "ER associated glutathione S-transferase; capable of homodimerization; glutathione transferase for Yvc1p vacuolar cation channel; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p" 2.5.1.18 ER associated glutathione S-transferase 2.5.1.18 Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) "GTT1; bifunctional glutathione transferase/peroxidase" 2.5.1.18 glutathione transferase "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+;glutathione + 4-hydroxy-2-nonenal = 4-hydroxy-2-nonenal-glutathione conjugate;glutathione + RX = a glutathione-toxin conjugate + HX" "RX + Glutathione <=> Halide + R-S-Glutathione;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH" 4 out of 5 RX + glutathione = HX + R-S-glutathione. RX + glutathione = HX + R-S-glutathione YES Glutathione metabolism "pathway from kegg; reaction from uniprot" "H675;H1101" glutathione-glutaredoxin redox reactions Glutathione metabolism "Glutathione metabolism;path:map00480;Metabolism of xenobiotics by cytochrome P450;path:map00980;Drug metabolism - cytochrome P450;path:map00982" endoplasmic reticulum membrane "nucleus;mitochondrion;mitochondrial membrane;endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" endoplasmic reticulum membrane -222 YKL045W "Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair" 2.7.7.- Subunit of DNA primase DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48. 2.7.7.- DNA primase large subunit (EC 2.7.7.-) (DNA polymerase alpha:primase complex p58 subunit) (DNA polymerase-primase complex p58 subunit) (Pol alpha-primase complex p58 subunit) (DNA primase 58 kDa subunit) "PRI2; DNA primase subunit PRI2" NA DNA PRImase "Detection of damage during initiation of DNA synthesis in S-phase;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere;RFC binding displaces Pol Alpha on the C-strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin;RFC binding displaces Pol Alpha;Loading of PCNA - Sliding Clamp Formation;RFC dissociates after sliding clamp formation;Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" NA NA NA NA a single stranded DNA = a short RNA Segment "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" NA 5 out of 5 NA 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA primase is required for DNA synthesis and double-strand break repair NA NA NA "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication" NA "Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand" NA nucleus -225 YKL069W "Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress" 1.8.4.14 Methionine-R-sulfoxide reductase Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Does not act on S-enantiomer of free methionine sulfoxide or R-enantiomer of dabsylated methionine sulfoxide. Involved in protection against oxidative stress. {ECO:0000269|PubMed:19049972}. 1.8.4.14 Free methionine-R-sulfoxide reductase (fRMsr) (EC 1.8.4.14) (GAF domain-containing protein YKL069W) "YKG9; L-methionine (R)-S-oxide reductase" 1.8.4.14 YKL069W "[thioredoxin]-disulfide + L-methionine + H2O => [thioredoxin]-dithiol + L-methionine (R)-S-oxide;[thioredoxin]-dithiol + L-methionine (R)-S-oxide => [thioredoxin]-disulfide + L-methionine + H2O" "L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine (R)-S-oxide + Thioredoxin;L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin" "[thioredoxin]-disulfide + L-methionine + H2O => [thioredoxin]-dithiol + L-methionine (R)-S-oxide;[thioredoxin]-dithiol + L-methionine (R)-S-oxide => [thioredoxin]-disulfide + L-methionine + H2O" "L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine (R)-S-oxide + Thioredoxin;L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin" L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin 5 out of 5 L-methionine + thioredoxin disulfide + H(2)O = L-methionine (R)-S-oxide + thioredoxin. {ECO:0000269|PubMed:19049972}. L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin YES Cysteine and methionine metabolism pathway from kegg E526 Cysteine and methionine metabolism "Cysteine and methionine metabolism;path:map00270" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -229 YKL087C "Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant" 4.4.1.- Cytochrome c1 heme lyase Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein. 4.4.1.- Cytochrome c1 heme lyase (CC1HL) (EC 4.4.1.-) "CYT2; cytochrome c1 heme lyase CYT2" 4.4.1.17 cytochrome c1 heme lyase a c-type cytochrome <=> heme c + an apo-[c-type cytochrome] Cytochrome c <=> Apocytochrome c + Heme 3 out of 5 NA Cytochrome c <=> Apocytochrome c + Heme YES Porphyrin and chlorophyll metabolism pathway from kegg Porphyrin and chlorophyll metabolism NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -231 YKL103C "Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress" 3.4.11.22 Vacuolar aminopeptidase yscI Resident vacuolar enzyme that catalyzes the removal of amino acids from the N-terminus of peptides and proteins. Also acts as the major cargo protein of the cytoplasm-to-vacuole targeting (Cvt) pathway. The precursor form of aminopeptidase 1 (prApe1) assembles into dodecamers and the propeptide mediates the aggregation of dodecamers into higher multimers. The multimers are then recognized via the propeptide by their receptor ATG19, and ATG19 further interacts with ATG11, which tethers the APE1-ATG19 complex to the pre-autophagosomal structure (PAS). The cargo-receptor complex (also Cvt complex) is selectively enwrapped by a double-membrane structure termed the Cvt vesicle under vegetative growth conditions and by a similar but larger double-membrane structure termed the autophagosome under nitrogen starvation conditions. The Cvt vesicle or the autophagosome fuses with the vacuolar membrane and release its content in the vacuolar lumen. In the vacuole, prApe1 is processed into mature aminopeptidase 1 (mApe1). {ECO:0000269|PubMed:11382752, ECO:0000269|PubMed:11430817, ECO:0000269|PubMed:15138258, ECO:0000269|PubMed:22123825, ECO:0000269|PubMed:363165, ECO:0000269|PubMed:8901576, ECO:0000269|PubMed:9214379, ECO:0000269|PubMed:9412464}. 3.4.11.22 Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I) "APE1, API, LAP4, YSC1; metalloaminopeptidase APE1" 3.4.11.22 vacuolar aminopeptidase ysc1 "L-Ala-Gly + H2O = L-Ala + Gly;L-Ala-L-Leu + H2O = L-Ala + L-Leu" "L-Ala-Gly + H2O = L-Ala + Gly;L-Ala-L-Leu + H2O = L-Ala + L-Leu" a protein + H2O => a proteinogenic amino acid + a peptide 5 out of 5 Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates. {ECO:0000269|PubMed:19185714, ECO:0000269|PubMed:363165, ECO:0000269|PubMed:3890752, ECO:0000269|PubMed:5147, ECO:0000269|PubMed:6352682}. "L-Ala-Gly + H2O <=> L-Ala + Gly;L-Ala-L-Leu + H2O <=> L-Ala + L-Leu" YES Hydrolysis of peptide bond no pathway from database NA vacuole "vacuole;extracellular;cytoplasm" vacuole -238 YKL144C "RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p" RNA polymerase III subunit C25 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation. DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III 25 kDa polypeptide) (RNA polymerase III subunit C25) "RPC25, YKL1; DNA-directed RNA polymerase III subunit RPC25" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus -239 YKL150W "Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis" 1.6.2.2 Mitochondrial NADH-cytochrome b5 reductase The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals. {ECO:0000269|PubMed:11420140}. 1.6.2.2 "NADH-cytochrome b5 reductase 2 (EC 1.6.2.2) (Mitochondrial cytochrome b reductase) (p34/p32) [Cleaved into: NADH-cytochrome b5 reductase p34 form; NADH-cytochrome b5 reductase p32 form]" "MCR1; cytochrome-b5 reductase" 1.6.2.2 NADH-cytochrome b5 reductase CYB5Rs reduce MetHb to Hb "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" "2 a ferricytochrome b5 + NADH => 2 a ferrocytochrome b5 + NAD+ + H+;2 a ferrihemoglobin + NADH = 2 a ferrohemoglobin + NAD+ + H+" NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ CYB5Rs reduce MetHb to Hb 5 out of 5 NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5. NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ YES Amino sugar and nucleotide sugar metabolism pathway from kegg H588 Amino sugar and nucleotide sugar metabolism Erythrocytes take up carbon dioxide and release oxygen "Amino sugar and nucleotide sugar metabolism;path:map00520" mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -253 YKL215C "5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress" 3.5.2.9 5-oxoprolinase Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. {ECO:0000269|PubMed:20349993, ECO:0000269|PubMed:20402795}. 3.5.2.9 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase) "OXP1; 5-oxoprolinase" 3.5.2.9 5-oxoprolinase (ATP-hydrolysing) OPLAH hydrolyses OPRO to L-Glu "5-oxo-L-proline + ATP + 2 H2O => L-glutamate + ADP + H(+) + phosphate;L-glutamate + ADP + H(+) + phosphate => 5-oxo-L-proline + ATP + 2 H2O" ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate "5-oxo-L-proline + ATP + 2 H2O => L-glutamate + ADP + H(+) + phosphate;L-glutamate + ADP + H(+) + phosphate => 5-oxo-L-proline + ATP + 2 H2O" ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate 5-oxo-L-proline + ATP + 2 H2O => L-glutamate + ADP + phosphate + H+ ATP + Pidolic acid + 2 H2O <=> ADP + Orthophosphate + L-Glutamate OPLAH hydrolyses OPRO to L-Glu 5 out of 5 ATP + 5-oxo-L-proline + 2 H(2)O = ADP + phosphate + L-glutamate. 5-oxo-L-proline + ATP + 2 H2O => L-glutamate + ADP + phosphate + H+ YES Glutathione metabolism pathway from kegg H436 Glutathione metabolism "γ-glutamyl cycle // 5-oxo-L-proline metabolism" Glutathione synthesis and recycling "Glutathione metabolism;path:map00480" cytoplasm cytoplasm cytoplasm -254 YKL218C "3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity" 4.3.1.16 3-hydroxyaspartate dehydratase Catalyzes the deamination of L-threo-3-hydroxyaspartate to oxaloacetate and ammonia. Shows a high specificity towards L-threo-3-hydroxyaspartate as other 3-hydroxyaminoacids, i.e. D,L-erythro- and D-threo-3-hydroxyaspartate, D-threonine, L-threonine, D,L-allothreonine, D-serine, and L-serine, are not substrates for this enzyme. Exhibits no detectable serine racemase activity. Is responsible for the 3-hydroxyaspartate resistance of S.cerevisiae, and thus may be involved in the detoxification of naturally occurring 3-hydroxyaspartate. {ECO:0000269|PubMed:12951240}. 4.3.1.16 L-threo-3-hydroxyaspartate ammonia-lyase (EC 4.3.1.16) (L-threo-3-hydroxyaspartate dehydratase) "SRY1; threo-3-hydroxy-L-aspartate ammonia-lyase SRY1" NA Serine Racemase NA "(3S)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate;NH4(+) + oxaloacetate => (3S)-3-hydroxy-L-aspartate" threo-3-hydroxy-L-aspartate = oxaloacetate + NH3 "(3S)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate;NH4(+) + oxaloacetate => (3S)-3-hydroxy-L-aspartate" threo-3-hydroxy-L-aspartate = oxaloacetate + NH3 (3S)-3-hydroxy-L-aspartate = oxaloacetate + ammonium NA NA 5 out of 5 Threo-3-hydroxy-L-aspartate = oxaloacetate + NH(3). {ECO:0000269|PubMed:12951240}. Threo-3-hydroxy-L-aspartate = oxaloacetate + NH(3) YES Other NA NA NA NA NA NA NA NA cytoplasm -255 YKL220C "Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels" 1.16.1.9 Ferric reductase and cupric reductase Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake. {ECO:0000269|PubMed:11120744, ECO:0000269|PubMed:9153234}. 1.16.1.9 Ferric/cupric reductase transmembrane component 2 (EC 1.16.1.9) (Ferric-chelate reductase 2) "FRE2; ferric/cupric-chelate reductase" ferric reductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+;2 an Fe(III)-siderophore + NADPH => 2 Fe2+ + 2 a siderophore + NADP+ + H+;2 ferric (2,3-dihydroxybenzoylserine)3 + NADPH + 9 H+ => 2 Fe2+ + 2 (2,3-dihydroxybenzoylserine)3 + NADP+" 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope "vacuole;cell envelope" cell envelope -256 YKR002W "Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping" 2.7.7.19 Poly(A) polymerase Polymerase component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. {ECO:0000269|PubMed:17850751, ECO:0000269|PubMed:18537269}. 2.7.7.19 Poly(A) polymerase (PAP) (EC 2.7.7.19) (Polynucleotide adenylyltransferase) "PAP1; polynucleotide adenylyltransferase PAP1" 2.7.7.19 Poly(A) Polymerase NA "ATP + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => ATP + RNAn" "ATP + RNA <=> Diphosphate + RNA;ATP + mRNA = diphosphate + mRNA;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+3'-A;ATP + RNA = diphosphate + RNA(A)n" "ATP + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => ATP + RNAn" "ATP + RNA <=> Diphosphate + RNA;ATP + mRNA = diphosphate + mRNA;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+3'-A;ATP + RNA = diphosphate + RNA(A)n" ATP + an mRNA = an mRNA + diphosphate NA NA 5 out of 5 ATP + RNA(n) = diphosphate + RNA(n+1). {ECO:0000269|PubMed:17850751, ECO:0000269|PubMed:18537269}. ATP + RNA(n) <=> diphosphate + RNA(n+1) YES mRNA surveillance pathway RNA synthesis H1118 NA NA mRNA surveillance pathway NA NA NA nucleus nucleus nucleus -257 YKR003W "Member of an oxysterol-binding protein family; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion; OSH6 has a paralog, OSH7, that arose from the whole genome duplication" NA Member of an oxysterol-binding protein family Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum (PubMed:23934110, PubMed:26206936). Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206936). {ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206936}. NA Oxysterol-binding protein homolog 6 "OSH6; oxysterol-binding protein OSH6" NA OxySterol binding protein Homolog "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" NA NA NA NA NA NA "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" 5 out of 5 NA "phosphatidylserine <=> phosphatidylserine; phosphatidylinositol 4-phosphate <=> phosphatidylinositol 4-phosphate" YES Lipid transport "Lipid transporter; deliver ps from ER membrane to plasma membrane for the exchanges of phosphatidylinositol 4-phosphate; phosphatidylserine[er] + phosphatidylinositol 4-phosphate[c] => phosphatidylserine[c] + phosphatidylinositol 4-phosphate[c]" NA NA NA NA NA "Acyl chain remodelling of PS;Synthesis of bile acids and bile salts" NA endoplasmic reticulum membrane "cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -259 YKR025W RNA polymerase III subunit C37 RNA polymerase III subunit C37 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation. {ECO:0000269|PubMed:16362040}. DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 37 kDa polypeptide) (RNA polymerase III subunit C37) "RPC37; DNA-directed RNA polymerase III subunit C37" RNA Polymerase C a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 3 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;RNA polymerase" NA nucleus nucleus nucleus -263 YKR076W "S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm" "1.8.5.1;2.5.1.18" S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis. {ECO:0000269|PubMed:16709151}. "2.5.1.18; 1.8.5.1" Glutathione S-transferase omega-like 2 (EC 2.5.1.18) (Extracellular mutant protein 4) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) "ECM4, GTO2; S-glutathionyl-(chloro)hydroquinone reductase" 1.8.5.7 ExtraCellular Mutant "L-dehydroascorbate + 2 glutathione => L-ascorbate + glutathione disulfide;L-ascorbate + glutathione disulfide => L-dehydroascorbate + 2 glutathione;glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate;5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione;L-dehydroascorbate + 2 glutathione => L-ascorbate + glutathione disulfide;L-ascorbate + glutathione disulfide => L-dehydroascorbate + 2 glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin;2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate" "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+;glutathione + 4-hydroxy-2-nonenal = 4-hydroxy-2-nonenal-glutathione conjugate;glutathione + RX = a glutathione-toxin conjugate + HX" 5 out of 5 "RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:16709151}.; 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate. {ECO:0000269|PubMed:16709151}." "RX + glutathione = HX + R-S-glutathione;2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate" YES Glutathione metabolism "pathway from kegg; reaction from uniprot" "H675;H1101;NA" "Glutathione metabolism;path:map00480;Metabolism of xenobiotics by cytochrome P450;path:map00980;Drug metabolism - cytochrome P450;path:map00982;NA" cytoplasm cytoplasm cytoplasm -266 YKR093W "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" Integral membrane peptide transporter Uptake of small peptides. Peptide transporter PTR2 (Peptide permease PTR2) "PTR2; Ptr2p" Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport" 4 out of 5 NA "di- peptide <=> di- peptide; tri-peptide <=> tri-peptide" YES peptide transport Uptake of small peptides. "Proton/oligopeptide cotransporters;Neutrophil degranulation" NA "vacuole;cell envelope" -269 YFL061W "Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p" 4.2.1.69 Cyanamide hydratase that detoxifies cyanamide Cyanamide hydratase involved in the detoxification and/or utilization of cyanamide, a toxic nitrile compound distributed widely in the environment. {ECO:0000269|PubMed:25847245}. 4.2.1.69 Cyanamide hydratase DDI2 (CAH) (EC 4.2.1.69) (DNA damage-inducible protein 2) "DDI2; cyanamide hydratase" 4.2.1.69 DNA Damage Inducible "urea => cyanamide + H2O;cyanamide + H2O => urea" urea = cyanamide + H2O "urea => cyanamide + H2O;cyanamide + H2O => urea" urea = cyanamide + H2O Urea <=> Cyanamide + H2O 4 out of 5 Urea = cyanamide + H(2)O. {ECO:0000269|PubMed:25847245}. Urea <=> Cyanamide + H2O YES Atrazine degradation pathway from kegg Atrazine degradation "Atrazine degradation;path:map00791;Microbial metabolism in diverse environments;path:map01120" -270 YFL060C "Protein of unknown function; nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin" "3.5.1.2;4.3.3.6" Protein of unknown function Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform. {ECO:0000250|UniProtKB:Q03144, ECO:0000269|PubMed:12271461}. "4.3.3.6; 3.5.1.2" Probable pyridoxal 5'-phosphate synthase subunit SNO3 (EC 4.3.3.6) (PDX2 homolog 3) (Pdx2.3) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) "SNO3; putative pyridoxal 5'-phosphate synthase" 4.3.3.6 SNZ proximal Open reading frame "L-glutamine + H2O => L-glutamate + NH4(+);L-glutamate + NH4(+) => L-glutamine + H2O;aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-glutamine + H2O = D-glutamate + NH3;a monocarboxylic acid amide + H2O = a monocarboxylate + NH3;L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine;L-glutamine + H2O => L-glutamate + NH4(+);L-glutamate + NH4(+) => L-glutamine + H2O" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+;L-glutamine + H2O = L-glutamate + NH3;D-glutamine + H2O = D-glutamate + NH3;a monocarboxylic acid amide + H2O = a monocarboxylate + NH3" D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O 4 out of 5 "D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate. {ECO:0000250|UniProtKB:Q03144}.; L-glutamine + H(2)O = L-glutamate + NH(3). {ECO:0000250|UniProtKB:Q03144}." "L-glutamine + H2O => L-glutamate + NH4(+);aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate" YES Vitamin B6 metabolism "pathway from kegg; reaction from rhea" "NA;NA" "PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. {ECO:0000250|UniProtKB:Q03144}." Vitamin B6 metabolism "Vitamin B6 metabolism;path:map00750;NA" cytoplasm -271 YFL059W "Member of a stationary phase-induced gene family; expressed in the presence of galactose; transcription of SNZ3 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3" 4.3.3.6 Member of a stationary phase-induced gene family Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. {ECO:0000250|UniProtKB:Q03148}. 4.3.3.6 Probable pyridoxal 5'-phosphate synthase subunit SNZ3 (PLP synthase subunit SNZ3) (EC 4.3.3.6) (PDX1 homolog 3) (Pdx1.3) "SNZ3; pyridoxine biosynthesis protein SNZ3" 4.3.3.6 SNooZe "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O 3 out of 5 D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate. {ECO:0000250|UniProtKB:Q03148}. D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O YES Vitamin B6 metabolism pathway from kegg "PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis." Vitamin B6 metabolism "Vitamin B6 metabolism;path:map00750" -272 YFL058W "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" Protein involved in synthesis of the thiamine precursor HMP Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. {ECO:0000269|PubMed:23048037}. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5 (HMP-P synthase) (Hydroxymethylpyrimidine phosphate synthase) (Thiamine biosynthesis protein 5) (Thiamine pyrimidine synthase) "THI5; 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" MONOMER3O-3915 [an HMP-P synthase]-L-histidine + pyridoxal 5'-phosphate => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + an HMP-P synthase Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine 5 out of 5 NA Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine YES Thiamine metabolism pathway from kegg thiamine biosynthesis "PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000305|PubMed:12777485}." "Thiamine metabolism;Metabolic pathways" superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis NA -273 YFL054C "Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol" Putative channel-like protein Uncharacterized membrane protein YFL054C "AQY3; Aqy3p" YFL054C "Aquaporin-9 passively transports glycerol into cell;Aquaporin-7 passively transports glycerol out of cell;Aquaporin-3 passively transports water out of cell;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport urea out of cells;Aquaporins passively transport urea out of cells;Aquaporins passively transport urea into cells;Aquaporins passively transport urea into cells" "Aquaporin-9 passively transports glycerol into cell;Aquaporin-7 passively transports glycerol out of cell;Aquaporin-3 passively transports water out of cell;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport urea out of cells;Aquaporins passively transport urea out of cells;Aquaporins passively transport urea into cells;Aquaporins passively transport urea into cells" 3 out of 5 NA glycerol <=> glycerol YES glycerol transport glycerol "Transport of glycerol from adipocytes to the liver by Aquaporins;Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins" NA cell envelope -275 YFL036W "Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Rpo41p also synthesizes RNA primers for mitochondrial DNA replication" 2.7.7.6 Mitochondrial RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. 2.7.7.6 DNA-directed RNA polymerase, mitochondrial (EC 2.7.7.6) "RPO41; DNA-directed RNA polymerase" 2.7.7.6 RNA POlymerase "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). {ECO:0000255|PROSITE-ProRule:PRU10031, ECO:0000255|PROSITE-ProRule:PRU10032}. 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase Mitochondrial RNA polymerase H1118 "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" mitochondrion "cytoplasm;mitochondrion" mitochondrion -284 YFR044C "Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant" 3.4.13.- Cys-Gly metallo-di-peptidase Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides. {ECO:0000269|PubMed:17179087, ECO:0000269|PubMed:19346245}. 3.4.13.- Cys-Gly metallodipeptidase DUG1 (EC 3.4.13.-) (Deficient in utilization of glutathione protein 1) (GSH degradosomal complex subunit DUG1) "DUG1; metallodipeptidase" MONOMER3O-4 CNDP2:2Mn2+ dimer hydrolyses CysGly L-cysteinyl-glycine + H2O => L-cysteine + glycine "Cys-Gly + H2O <=> L-Cysteine + Glycine;R-S-Cysteinylglycine + H2O <=> S-Substituted L-cysteine + Glycine" CNDP2:2Mn2+ dimer hydrolyses CysGly 5 out of 5 NA "Cys-Gly + H2O <=> L-Cysteine + Glycine;R-S-Cysteinylglycine + H2O <=> S-Substituted L-cysteine + Glycine" YES cysteine and methionine metabolism pathway from E.coli model. Cysteine metabolism was changed into cysteine and methionine metabolism based on yeast 7.7 E528 "superpathway of glutathione metabolism (truncated gamma-glutamyl cycle);glutathione degradation" "Glutathione metabolism;Metabolic pathways" "superpathway of glutathione metabolism (truncated γ-glutamyl cycle) // glutathione degradation // γ-glutamyl cycle // glutathione degradation (DUG pathway)" Glutathione synthesis and recycling NA cytoplasm "cytoplasm;mitochondrion" cytoplasm -286 YFR055W "Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner" 4.4.1.8 Beta-lyase involved in the production of thiols 4.4.1.8 Putative cystathionine beta-lyase (CBL) (EC 4.4.1.8) (Beta-cystathionase) (Cysteine lyase) (Increased recombination centers protein 7) "IRC7; cysteine-S-conjugate beta-lyase IRC7" 4.4.1.8 cystathionine beta-lyase "L-cystathionine + H2O => L-homocysteine + NH4(+) + pyruvate;L-homocysteine + NH4(+) + pyruvate => L-cystathionine + H2O" "2-aminoprop-2-enoate = 2-iminopropanoate;2-iminopropanoate + H2O = pyruvate + NH3;L-cysteine + H2O = sulfide + NH3 + pyruvate;L-cystathionine = L-homocysteine + 2-aminoprop-2-enoate;L-cystathionine + H2O = L-homocysteine + pyruvate + NH3;L-cystine + H2O = L-thiocysteine + pyruvate + NH3;L-Selenocystathionine + H2O <=> Selenohomocysteine + Ammonia + Pyruvate" "L-cystathionine + H2O => L-homocysteine + NH4(+) + pyruvate;L-homocysteine + NH4(+) + pyruvate => L-cystathionine + H2O" "2-aminoprop-2-enoate = 2-iminopropanoate;2-iminopropanoate + H2O = pyruvate + NH3;L-cysteine + H2O = sulfide + NH3 + pyruvate;L-cystathionine = L-homocysteine + 2-aminoprop-2-enoate;L-cystathionine + H2O = L-homocysteine + pyruvate + NH3;L-cystine + H2O = L-thiocysteine + pyruvate + NH3;L-Selenocystathionine + H2O <=> Selenohomocysteine + Ammonia + Pyruvate" "L-cystathionine + H2O => ammonium + pyruvate + L-homocysteine;L-selenocystathionine + H2O = ammonium + pyruvate + seleno-L-homocysteine" "L-Cysteine + H2O <=> Hydrogen sulfide + Pyruvate + Ammonia;L-Cystathionine + H2O <=> L-Homocysteine + Ammonia + Pyruvate;L-Cystine + H2O <=> Pyruvate + Ammonia + Thiocysteine;L-Selenocystathionine + H2O <=> Selenohomocysteine + Ammonia + Pyruvate" 4 out of 5 L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate. L-cystathionine + H2O <=> L-homocysteine + NH4(+) + pyruvate YES Cysteine and methionine metabolism "pathway from kegg; reaction from uniprot; reaction from rhea" "E83;E469" "PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1." "Cysteine and methionine metabolism;Selenocompound metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of amino acids" superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) // cysteine biosynthesis IV (fungi) // homocysteine and cysteine interconversion "Cysteine and methionine metabolism;path:map00270;Selenocompound metabolism;path:map00450;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" cytoplasm -292 YDL021W "Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM2 has a paralog, GPM3, that arose from the whole genome duplication" 5.4.2.11 Homolog of Gpm1p phosphoglycerate mutase Could be non-functional. 5.4.2.11 Phosphoglycerate mutase 2 (PGAM 2) (EC 5.4.2.11) (BPG-dependent PGAM 2) (MPGM 2) (Phosphoglyceromutase 2) "GPM2; phosphoglycerate mutase family protein GPM2" 5.4.2.11 Glycerate PhosphoMutase "2-phospho-D-glycerate => 3-phospho-D-glycerate;3-phospho-D-glycerate => 2-phospho-D-glycerate;2,3-bisphospho-D-glycerate + H2O => 3-phospho-D-glycerate + phosphate;3-phospho-D-glycerate + phosphate => 2,3-bisphospho-D-glycerate + H2O" "2-phospho-D-glycerate = 3-phospho-D-glycerate;2,3-Bisphospho-D-glycerate + Protein histidine <=> 3-Phospho-D-glycerate + Protein N(tau)-phospho-L-histidine;[enzyme]-Ntau-phospho-L-histidine + 2/3-bisphospho-D-glycerate = [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate;[enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-Ntau-phospho-L-histidine + 3-phospho-D-glycerate;[enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-Ntau-phospho-L-histidine + 2/3-phospho-D-glycerate;2-phospho-D-glycerate + 2,3-bisphosphoglycerate = 3-phospho-D-glycerate + 2,3-bisphosphoglycerate;[enzyme]-Ntau-phospho-L-histidine + 2-phospho-D-glycerate = [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate" "2-phospho-D-glycerate => 3-phospho-D-glycerate;3-phospho-D-glycerate => 2-phospho-D-glycerate;2,3-bisphospho-D-glycerate + H2O => 3-phospho-D-glycerate + phosphate;3-phospho-D-glycerate + phosphate => 2,3-bisphospho-D-glycerate + H2O" "2-phospho-D-glycerate = 3-phospho-D-glycerate;2,3-Bisphospho-D-glycerate + Protein histidine <=> 3-Phospho-D-glycerate + Protein N(tau)-phospho-L-histidine;[enzyme]-Ntau-phospho-L-histidine + 2/3-bisphospho-D-glycerate = [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate;[enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-Ntau-phospho-L-histidine + 3-phospho-D-glycerate;[enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-Ntau-phospho-L-histidine + 2/3-phospho-D-glycerate;2-phospho-D-glycerate + 2,3-bisphosphoglycerate = 3-phospho-D-glycerate + 2,3-bisphosphoglycerate;[enzyme]-Ntau-phospho-L-histidine + 2-phospho-D-glycerate = [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate" 2-phospho-D-glycerate <=> 3-phospho-D-glycerate 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate 4 out of 5 2-phospho-D-glycerate = 3-phospho-D-glycerate. 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate YES Glycolysis / Gluconeogenesis Could be non-functional. Pathway from kegg E632 "PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5." "Glycolysis / Gluconeogenesis;Glycine, serine and threonine metabolism;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids" gluconeogenesis // glycolysis "Glycolysis / Gluconeogenesis;path:map00010;Glycine, serine and threonine metabolism;path:map00260;Methane metabolism;path:map00680;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" cytoplasm cytoplasm cytoplasm -293 YDL024C "Protein of unknown function; involved in invasive and pseudohyphal growth" 3.1.3.2 Protein of unknown function 3.1.3.2 Probable acid phosphatase DIA3 (EC 3.1.3.2) (Digs into agar protein 3) "DIA3; putative acid phosphatase DIA3" 3.1.3.2 Digs Into Agar "D-glycerate 2-phosphate + H2O = D-glycerate + phosphate;glycerol 1-phosphate + H2O = glycerol + phosphate;D-glycerate 3-phosphate + H2O = D-glycerate + phosphate;a phosphate monoester + H2O = an alcohol + phosphate;glycerol 2-phosphate + H2O = glycerol + phosphate;4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate;alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate;D-glucose 6-phosphate + H2O = D-glucose + phosphate;diphosphate + H2O = 2 phosphate;ATP + H2O = ADP + phosphate;dTTP + H2O = dTDP + phosphate;GDP + H2O = GMP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;GTP + H2O = GDP + phosphate;phosphoenolpyruvate + H2O = pyruvate + phosphate;phosphocholine + H2O = choline + phosphate;thiamine phosphate + H2O = thiamine + phosphate;FMN + H2O = riboflavin + phosphate;UDP + H2O = UMP + phosphate;dTDP + H2O = dTMP + phosphate;UTP + H2O + H+/in = UDP + phosphate + H+/out;CTP + H2O + H+/in = CDP + phosphate + H+/out;D-gluconate 6-phosphate + H2O = D-gluconate + phosphate;O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate;O-phospho-L-threonine + H2O = L-threonine + phosphate;3'AMP + H2O = adenosine + phosphate;O-phosphoserine + H2O = serine + phosphate;phenyl phosphate = phenol + phosphate;dCMP + H2O = deoxycytidine + phosphate;pyridoxamine 5'-phosphate + H2O = pyridoxamine + phosphate;pyridoxine 5'-phosphate + H2O = pyridoxine + phosphate;3'-TMP + H2O = thymidine + phosphate;2'-deoxyuridine 5'-phosphate + H2O = 2'-deoxyuridine + phosphate;adenosine 5'-diphosphate + H2O = AMP + phosphate;dAMP + H2O = 2'-deoxyadenosine + phosphate;nicotinamide mononucleotide + H2O = nicotinamide riboside + phosphate;adenosine monophosphate + H2O = adenosine + phosphate;guanosine monophosphate + H2O = guanosine + phosphate;dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate;2'-AMP + H2O = adenosine + phosphate;3'-dUMP + H2O = deoxyuridine + phosphate;3'-dCMP + H2O = deoxycytidine + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;3'-GMP + H2O = guanosine + phosphate;D-mannose 6-phosphate + H2O = D-mannose + phosphate;D-glyceraldehyde 3-phosphate + H2O = D-glyceraldehyde + phosphate;NADP+ + H2O = NAD+ + phosphate;CDP + H2O = CMP + phosphate;NADPH + H2O = NADH + phosphate;CMP + H2O = cytidine + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate;lysophosphatidate + H2O = monoacylglycerol + phosphate;uridine 5'-phosphate + H2O = uridine + phosphate;3'-UMP + H2O = uridine + phosphate;3'-CMP + H2O = cytidine + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate;2'-deoxyadenosine 3'-monophosphate + H2O = 2'-deoxyadenosine + phosphate;2'-deoxyguanosine 3'-monophosphate + H2O = 2'-deoxyguanosine + phosphate;carbamoyl phosphate + H2O = carbamate + phosphate;thiamine diphosphate + 2 H2O = thiamine + 2 phosphate;ADP + 2 H2O = adenosine + 2 phosphate" "D-glycerate 2-phosphate + H2O = D-glycerate + phosphate;glycerol 1-phosphate + H2O = glycerol + phosphate;D-glycerate 3-phosphate + H2O = D-glycerate + phosphate;a phosphate monoester + H2O = an alcohol + phosphate;glycerol 2-phosphate + H2O = glycerol + phosphate;4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate;alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate;D-glucose 6-phosphate + H2O = D-glucose + phosphate;diphosphate + H2O = 2 phosphate;ATP + H2O = ADP + phosphate;dTTP + H2O = dTDP + phosphate;GDP + H2O = GMP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;GTP + H2O = GDP + phosphate;phosphoenolpyruvate + H2O = pyruvate + phosphate;phosphocholine + H2O = choline + phosphate;thiamine phosphate + H2O = thiamine + phosphate;FMN + H2O = riboflavin + phosphate;UDP + H2O = UMP + phosphate;dTDP + H2O = dTMP + phosphate;UTP + H2O + H+/in = UDP + phosphate + H+/out;CTP + H2O + H+/in = CDP + phosphate + H+/out;D-gluconate 6-phosphate + H2O = D-gluconate + phosphate;O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate;O-phospho-L-threonine + H2O = L-threonine + phosphate;3'AMP + H2O = adenosine + phosphate;O-phosphoserine + H2O = serine + phosphate;phenyl phosphate = phenol + phosphate;dCMP + H2O = deoxycytidine + phosphate;pyridoxamine 5'-phosphate + H2O = pyridoxamine + phosphate;pyridoxine 5'-phosphate + H2O = pyridoxine + phosphate;3'-TMP + H2O = thymidine + phosphate;2'-deoxyuridine 5'-phosphate + H2O = 2'-deoxyuridine + phosphate;adenosine 5'-diphosphate + H2O = AMP + phosphate;dAMP + H2O = 2'-deoxyadenosine + phosphate;nicotinamide mononucleotide + H2O = nicotinamide riboside + phosphate;adenosine monophosphate + H2O = adenosine + phosphate;guanosine monophosphate + H2O = guanosine + phosphate;dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate;2'-AMP + H2O = adenosine + phosphate;3'-dUMP + H2O = deoxyuridine + phosphate;3'-dCMP + H2O = deoxycytidine + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;3'-GMP + H2O = guanosine + phosphate;D-mannose 6-phosphate + H2O = D-mannose + phosphate;D-glyceraldehyde 3-phosphate + H2O = D-glyceraldehyde + phosphate;NADP+ + H2O = NAD+ + phosphate;CDP + H2O = CMP + phosphate;NADPH + H2O = NADH + phosphate;CMP + H2O = cytidine + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate;lysophosphatidate + H2O = monoacylglycerol + phosphate;uridine 5'-phosphate + H2O = uridine + phosphate;3'-UMP + H2O = uridine + phosphate;3'-CMP + H2O = cytidine + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate;2'-deoxyadenosine 3'-monophosphate + H2O = 2'-deoxyadenosine + phosphate;2'-deoxyguanosine 3'-monophosphate + H2O = 2'-deoxyguanosine + phosphate;carbamoyl phosphate + H2O = carbamate + phosphate;thiamine diphosphate + 2 H2O = thiamine + 2 phosphate;ADP + 2 H2O = adenosine + 2 phosphate" "a phosphate monoester + H2O => an alcohol + phosphate;thiamine phosphate + H2O => thiamine + phosphate" "FMN + H2O <=> Riboflavin + Orthophosphate;Thiamin monophosphate + H2O <=> Thiamine + Orthophosphate" 3 out of 5 A phosphate monoester + H(2)O = an alcohol + phosphate. "FMN + H2O <=> Riboflavin + Orthophosphate;Thiamin monophosphate + H2O <=> Thiamine + Orthophosphate" YES Thiamine metabolism pathway from kegg "E15;E510;H18;H977" "Thiamine metabolism;Riboflavin metabolism;Metabolic pathways" phosphate acquisition // superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // thiamin diphosphate biosynthesis IV (eukaryotes) "Riboflavin metabolism;path:map00740;Metabolic pathways;path:map01100" cell envelope -305 YDL102W "Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)" 2.7.7.7 Catalytic subunit of DNA polymerase delta DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. POL3 contains the polymerase active site and most likely the active site for the 3'-5' exonuclease activity. {ECO:0000269|PubMed:1648480}. 2.7.7.7 DNA polymerase delta catalytic subunit (EC 2.7.7.7) (DNA polymerase III) "POL3, CDC2, HPR6, TEX1; DNA-directed DNA polymerase delta POL3" 2.7.7.7 POLymerase "CIA Targeting Complex transfers 4Fe-4S clusters to apoproteins;Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination" "Cytosolic iron-sulfur cluster assembly (yeast);Removal of the Flap Intermediate;Processive synthesis on the lagging strand" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus -310 YDL120W "Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog FXN is mutated in Friedrich's ataxia; human FTL gene can complement yeast yfh1 null mutant" 1.16.3.1 Mitochondrial matrix iron chaperone Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain. {ECO:0000269|PubMed:15961414, ECO:0000269|PubMed:16371422, ECO:0000269|PubMed:17027502, ECO:0000269|PubMed:19884169, ECO:0000269|PubMed:9180083, ECO:0000269|PubMed:9988680}. 1.16.3.1 Frataxin homolog, mitochondrial (EC 1.16.3.1) [Cleaved into: Frataxin homolog intermediate form] "YFH1; ferroxidase" 1.16.3.1 frataxin "TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix;TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix;Precursor proteins enter TIM23 PAM complex;Precursor proteins enter TIM23 PAM complex;MPP hydrolyzes presequence of matrix precursors;MPP hydrolyzes presequence of matrix precursors;FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster;Frataxin binds iron" "4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O;4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2" "4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O;4 Cu+ + 4 H+ + O2 = 4 Cu2+ + 2 H2O;4 Mn(II) + 4 H+ + O2 = 4 Mn(III) + 2 H2O;2 hydroquinone + O2 = 2 quinone + 2 H2O" "4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O;4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2" "4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O;4 Cu+ + 4 H+ + O2 = 4 Cu2+ + 2 H2O;4 Mn(II) + 4 H+ + O2 = 4 Mn(III) + 2 H2O;2 hydroquinone + O2 = 2 quinone + 2 H2O" a [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex + 2 Fe3+ => a [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex Oxygen + 4 Fe2+ + 4 H+ <=> 4 Fe3+ + 2 H2O 5 out of 5 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O. {ECO:0000269|PubMed:16371422}. 4 Fe(2+) + 4 H(+) + O2 <=> 4 Fe(3+) + 2 H2O YES iron-sulfur cluster biosynthesis "pathway from biocyc; reaction from biocyc is wrong; reaction from rhea" "E532;H587" Porphyrin and chlorophyll metabolism iron-sulfur cluster biosynthesis Mitochondrial iron-sulfur cluster biogenesis "Porphyrin and chlorophyll metabolism;path:map00860" mitochondrion mitochondrion mitochondrion -314 YDL140C "RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime" 2.7.7.6 RNA polymerase II largest subunit B220 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcription cycle, Pol II, general transcription factors and the Mediator complex assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcription elongation in which it moves on the template as the transcript elongates. Pol II appears to oscillate between inactive and active conformations at each step of nucleotide addition. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Pol II is composed of mobile elements that move relative to each other. The core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. The clamp element (portions of RPB1, RPB2 and RPB3) is connected to the core through a set of flexible switches and moves to open and close the cleft. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. In elongating Pol II, the lid loop (RPB1) appears to act as a wedge to drive apart the DNA and RNA strands at the upstream end of the transcription bubble and guide the RNA strand toward the RNA exit groove located near the base of the largely unstructured CTD domain of RPB1. The rudder loop (RPB1) interacts with single-stranded DNA after separation from the RNA strand, likely preventing reassociation with the exiting RNA. The cleft is surrounded by jaws: an upper jaw formed by portions of RBP1, RPB2 and RPB9, and a lower jaw, formed by RPB5 and portions of RBP1. The jaws are thought to grab the incoming DNA template, mainly by RPB5 direct contacts to DNA. 2.7.7.6 DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit 1) (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (RNA polymerase II subunit B220) "RPO21, RPB1, RPB220, SUA8; DNA-directed RNA polymerase II core subunit RPO21" 2.7.7.6 RNA POlymerase "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus "nucleus;mitochondrion;cytoplasm" nucleus -316 YDL150W RNA polymerase III subunit C53 RNA polymerase III subunit C53 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation. {ECO:0000269|PubMed:16362040}. DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (C53) (DNA-directed RNA polymerase III 47 kDa polypeptide) "RPC53, RPC4; DNA-directed RNA polymerase III subunit C53" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus -319 YDL164C "DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; DNA ligase I mutants trigger ubiquitination of PCNA at K107, facilitating Rad59p-mediated bypass of unligated Okazaki fragments; human homolog LIG1 can complement yeast cdc9 temperature-sensitive mutant at restrictive temperature" 6.5.1.1 DNA ligase I found in nucleus and mitochondria DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. The mitochondrial form is required for mitochondrial DNA maintenance but is non-essential while the nuclear form is essential for cell viability. 6.5.1.1 DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) "CDC9, MMS8; DNA ligase (ATP) CDC9" "6.5.1.1;6.5.1.6;6.5.1.7" Cell Division Cycle "LIG1 binds APEX1 and PCNA at SSB;DNA ligase I ligates single stranded nick in double stranded DNA;LIG1 bound to APEX1 and PCNA ligates SSB;Ligation of newly synthesized repair patch to incised DNA in TC-NER;Joining of adjacent Okazaki fragments" "ATP + [DNA ligase]-L-lysine = [DNA ligase]-N6-(5'-adenylyl)-L-lysine + diphosphate;ATP + ADP = P1-(5'-adenosyl),P3-(5'-adenosyl)triphosphate + diphosphate;ATP + DNA(n) + 5'-Phospho-DNA(m) <=> AMP + Diphosphate + DNA(n+m);[DNA]-3'-hydroxyl + 5'-phospho-[DNA] + ATP = DNAn + AMP + diphosphate;dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n;[DNA ligase]-N6-(5'-adenylyl)-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;ADP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + phosphate + (deoxyribonucleotide)n+m;ATP + (deoxyribonucleotide)20 + (deoxyribonucleotide)20 = AMP + diphosphate + (deoxyribonucleotide)40;ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)m+n;ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m;ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate;(deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP" "ATP + [DNA ligase]-L-lysine = [DNA ligase]-N6-(5'-adenylyl)-L-lysine + diphosphate;ATP + ADP = P1-(5'-adenosyl),P3-(5'-adenosyl)triphosphate + diphosphate;ATP + DNA(n) + 5'-Phospho-DNA(m) <=> AMP + Diphosphate + DNA(n+m);[DNA]-3'-hydroxyl + 5'-phospho-[DNA] + ATP = DNAn + AMP + diphosphate;dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n;[DNA ligase]-N6-(5'-adenylyl)-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;ADP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + phosphate + (deoxyribonucleotide)n+m;ATP + (deoxyribonucleotide)20 + (deoxyribonucleotide)20 = AMP + diphosphate + (deoxyribonucleotide)40;ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)m+n;ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m;ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate;(deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP" a [DNA]-3'-hydroxyl + a 5'-phospho-[DNA] + ATP => DNAn + AMP + diphosphate "ATP + DNA(n) + 5'-Phospho-DNA(m) <=> AMP + Diphosphate + DNA(n+m);NAD+ + DNA(n) + 5'-Phospho-DNA(m) <=> AMP + Nicotinamide D-ribonucleotide + DNA(n+m);ADP + DNA(n) + 5'-Phospho-DNA(m) <=> AMP + Orthophosphate + DNA(n+m);GTP + DNA(n) + 5'-Phospho-DNA(m) <=> GMP + Diphosphate + DNA(n+m)" 5 out of 5 ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate. {ECO:0000255|PROSITE-ProRule:PRU10135}. 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" "DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Gap-filling DNA repair synthesis and ligation in TC-NER;Processive synthesis on the lagging strand" NA "mitochondrion;nucleus" "nucleus;mitochondrion" "mitochondrion;nucleus" -320 YDL166C "Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p; complex with Rps14 is conserved between humans, yeast, and arches; may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes; human TAF9 functionally complements the lethality of the null mutation" 2.7.4.3 Essential NTPase required for small ribosome subunit synthesis Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity (By similarity). Involved in 18S rRNA maturation. Required for cleavage of the 20S pre-rRNA at site D in the cytoplasm. Involved in oxidative stress response. Required for POS9-dependent target gene transcription upon oxidative stress. {ECO:0000255|HAMAP-Rule:MF_03173, ECO:0000269|PubMed:10692169, ECO:0000269|PubMed:12837249, ECO:0000269|PubMed:16287850}. 2.7.4.3 Adenylate kinase isoenzyme 6 homolog FAP7 (AK6) (EC 2.7.4.3) (Dual activity adenylate kinase/ATPase) (AK/ATPase) (POS9-activating factor 7) "FAP7; nucleoside-triphosphatase" 2.7.4.3 Factor Activating Pos9 AK6 phosphorylates (d)NMPs to (d)NDPs "AMP + ATP => 2 ADP;2 ADP => AMP + ATP" "ATP + AMP = 2 ADP;ATP + dAMP = ADP + dADP;GTP + AMP = GDP + ADP;ATP + CDP = ADP + CTP;ATP + CMP = ADP + CDP;UTP + AMP = UDP + ADP;Thiamin diphosphate + ADP <=> Thiamin triphosphate + AMP" "AMP + ATP => 2 ADP;2 ADP => AMP + ATP" "ATP + AMP = 2 ADP;ATP + dAMP = ADP + dADP;GTP + AMP = GDP + ADP;ATP + CDP = ADP + CTP;ATP + CMP = ADP + CDP;UTP + AMP = UDP + ADP;Thiamin diphosphate + ADP <=> Thiamin triphosphate + AMP" "ATP + AMP <=> 2 ADP;ATP + dAMP <=> ADP + dADP" AK6 phosphorylates (d)NMPs to (d)NDPs 5 out of 5 ATP + AMP = 2 ADP. {ECO:0000255|HAMAP-Rule:MF_03173}. "ATP + AMP <=> 2 ADP;ATP + dAMP <=> ADP + dADP" YES Purine metabolism pathway from kegg "E228;E598;H56" "Purine metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Ribosome biogenesis in eukaryotes" Interconversion of nucleotide di- and triphosphates "Purine metabolism;path:map00230;Thiamine metabolism;path:map00730;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Biosynthesis of antibiotics;path:map01130" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -323 YDL193W "Forms dehydrodolichyl diphosphate syntase complex with RER2 or SRT1; tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY, suggesting that Nus1p may be involved in protein trafficking; mutations in human homolog NUS1 have been implicated in congenital scoliosis, neurological impairment, refractory epilepsy, hearing deficit, and visual impairment; human cis-prenyltransferase complex complements yeast null mutant" 2.5.1.87 Forms dehydrodolichyl diphosphate syntase complex with RER2 or SRT1 With SRT1 or RER2, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). {ECO:0000269|PubMed:25066056}. 2.5.1.87 Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Di-trans,poly-cis-decaprenylcistransferase) (Nuclear undecaprenyl pyrophosphate synthase 1) (Undecaprenyl diphosphate synthase) (UDS) "NUS1; ditrans,polycis-polyprenyl diphosphate synthase" 2.5.1.87 dehydrodolichyl diphosphate syntase NUS1 subunit DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP NA "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate;(2E,6E)-farnesyl diphosphate + 13 isopentenyl diphosphate = 13 diphosphate + di-trans,poly-cis-hexadecaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = di-trans, poly-cis-polyisoprenyl diphosphate + diphosphate;geranyl diphosphate + n isopentenyl diphosphate = n diphosphate + di-trans,poly-cis-polyprenyl diphosphate;(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n: 10-55);(2E,6E)-farnesyl diphosphate + 14 isopentenyl diphosphate = 14 diphosphate + di-trans,poly-cis-heptadecaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + di-trans,poly-cis-octaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + di-trans,poly-cis-nonaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 19 isopentenyl diphosphate = 19 diphosphate + di-trans,poly-cis-docosaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 21 isopentenyl diphosphate = 21 diphosphate + di-trans,poly-cis tetracosaprenyl diphosphate" NA "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate;(2E,6E)-farnesyl diphosphate + 13 isopentenyl diphosphate = 13 diphosphate + di-trans,poly-cis-hexadecaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = di-trans, poly-cis-polyisoprenyl diphosphate + diphosphate;geranyl diphosphate + n isopentenyl diphosphate = n diphosphate + di-trans,poly-cis-polyprenyl diphosphate;(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n: 10-55);(2E,6E)-farnesyl diphosphate + 14 isopentenyl diphosphate = 14 diphosphate + di-trans,poly-cis-heptadecaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + di-trans,poly-cis-octaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + di-trans,poly-cis-nonaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 19 isopentenyl diphosphate = 19 diphosphate + di-trans,poly-cis-docosaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 21 isopentenyl diphosphate = 21 diphosphate + di-trans,poly-cis tetracosaprenyl diphosphate" (2E,6E)-farnesyl diphosphate + 13 isopentenyl diphosphate => di-trans, poly-cis-polyprenyl diphosphate (C80) + 13 diphosphate trans,trans-Farnesyl diphosphate + n Isopentenyl diphosphate <=> Dehydrodolichol diphosphate + n Diphosphate NA 5 out of 5 (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55). {ECO:0000269|PubMed:25066056}. trans,trans-Farnesyl diphosphate + n Isopentenyl diphosphate <=> Dehydrodolichol diphosphate + n Diphosphate YES Terpenoid backbone biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation. {ECO:0000305}." "Terpenoid backbone biosynthesis;Biosynthesis of secondary metabolites" dolichol and dolichyl phosphate biosynthesis Synthesis of Dolichyl-phosphate "Terpenoid backbone biosynthesis;path:map00900;Biosynthesis of secondary metabolites;path:map01110" "endoplasmic reticulum membrane;lipid particle;nucleus" "nucleus;endoplasmic reticulum;endoplasmic reticulum membrane;lipid particle" "nucleus;endoplasmic reticulum membrane;lipid particle" -327 YDL219W "D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes" 3.1.-.- D-Tyr-tRNA(Tyr) deacylase " An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs (Probable). Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr) (PubMed:10766779). May also deacylate mischarged D-leucyl-tRNA(Leu) (PubMed:10918062). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality (By similarity). {ECO:0000250|UniProtKB:Q8IIS0, ECO:0000269|PubMed:10766779, ECO:0000305|PubMed:10918062}." "3.1.1.96; 3.1.1.-" D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (EC 3.1.1.-) "DTD1; D-tyrosyl-tRNA(Tyr) deacylase" NA D-Tyr-tRNA(Tyr) Deacylase NA NA NA "a D-aminoacyl-tRNA + H2O => a D-amino acid + H(+) + tRNA;a D-amino acid + H(+) + tRNA => a D-aminoacyl-tRNA + H2O" "D-aminoacyl-[tRNA] + H2O = D-amino acid + uncharged tRNA + H+;D-tyrosyl-tRNATyr + H2O = D-tyrosine + tRNATyr;a D-aminoacyl-tRNA + H2O = a D-amino acid + tRNA;D-aminoacyl-tRNA + H2O = D-amino acid + tRNA;D-Tyr-tRNA + H2O = D-Tyr + tRNA" NA NA NA 5 out of 5 "Glycyl-tRNA(Ala) + H(2)O = glycine + tRNA(Ala). {ECO:0000250|UniProtKB:Q8IIS0}.; A D-aminoacyl-tRNA + H(2)O = a D-amino acid + tRNA. {ECO:0000305|PubMed:10766779}." "Glycyl-tRNA(Ala) + H(2)O <=> glycine + tRNA(Ala); D-leucyl-tRNA(Leu) <=> D-leu + tRNA(Leu); D-tyrosyl-tRNA(Tyr) <=> D-tyrosine + tRNA(Tyr)" YES other "D-Tyr-tRNA(Tyr) deacylase;" "NA;NA" NA NA NA NA NA "NA;NA" cytoplasm cytoplasm cytoplasm -330 YDL232W "Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex" 2.4.99.18 Subunit of the oligosaccharyltransferase complex of the ER lumen Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. OST4 is required for recruitment of OST3 or OST6 to the OST complex. It is essential for cell growth at 37 but not at 25 degrees Celsius. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4 (Oligosaccharyl transferase subunit OST4) (EC 2.4.99.18) (Oligosaccharyl transferase 4 kDa subunit) (OTase 4 kDa subunit) "OST4; olichyl-diphosphooligosaccharide--protein glycotransferase OST4" oligosaccharyl transferase complex OST4 subunit "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "mitochondrion;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -331 YDL236W "Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts" 3.1.3.41 Conserved phosphatase acting as a metabolite repair enzyme PHO13 is dispensable for vegetative growth and sporulation. 3.1.3.41 4-nitrophenylphosphatase (PNPPase) (EC 3.1.3.41) "PHO13; 4-nitrophenylphosphatase" 3.1.3.41 p-nitrophenyl phosphatase "4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate;4-nitrophenol + H(+) + phosphate => 4-nitrophenyl phosphate + H2O" 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate "4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate;4-nitrophenol + H(+) + phosphate => 4-nitrophenyl phosphate + H2O" 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate 4-nitrophenyl phosphate + H2O => 4-nitrophenol + phosphate + H+ 4-Nitrophenyl phosphate + H2O <=> 4-Nitrophenol + Orthophosphate 5 out of 5 4-nitrophenyl phosphate + H(2)O = 4-nitrophenol + phosphate. 4-nitrophenyl phosphate + H2O <=> 4-nitrophenol + phosphate YES Aminobenzoate degradation pathway from kegg H639 "Aminobenzoate degradation;path:map00627;Microbial metabolism in diverse environments;path:map01120" "nucleus;cytoplasm" -332 YDL243C "Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" Putative aryl-alcohol dehydrogenase 1.1.1.- Probable aryl-alcohol dehydrogenase AAD4 (EC 1.1.1.-) "AAD4; putative aryl-alcohol dehydrogenase" aryl-alcohol dehydrogenase "3-chlorobenzyl alcohol + NAD+ = 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ = 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ = 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ = p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ = 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ = an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ = benzaldehyde + NADH + H+" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism "pathway from E.coli model; reaction from biocyc" "E646;E743;H1286" NA -333 YDL244W "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" Protein involved in synthesis of the thiamine precursor HMP Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. {ECO:0000250|UniProtKB:P43534}. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI13 (HMP-P synthase) (Hydroxymethylpyrimidine phosphate synthase) (Thiamine biosynthesis protein 13) (Thiamine pyrimidine synthase) "THI13; 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" MONOMER3O-9145 [an HMP-P synthase]-L-histidine + pyridoxal 5'-phosphate => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + an HMP-P synthase Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine 3 out of 5 NA Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine YES Thiamine metabolism pathway from kegg thiamine biosynthesis "PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000305|PubMed:12777485}." "Thiamine metabolism;Metabolic pathways" superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis NA -334 YDL246C "Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase" 1.1.1.14 Sorbitol dehydrogenase 1.1.1.14 Sorbitol dehydrogenase 2 (EC 1.1.1.14) (L-iditol 2-dehydrogenase 2) "SOR2; L-iditol 2-dehydrogenase SOR2" 1.1.1.14 Unknown "L-iditol + NAD(+) => L-sorbopyranose + H(+) + NADH;L-sorbopyranose + H(+) + NADH => L-iditol + NAD(+)" "xylitol + NAD+ = D-xylulose + NADH + H+;L-iditol + NAD+ = L-sorbose + NADH + H+;ribitol + NAD+ = D-ribulose + NADH + H+;D-mannitol + NAD+ = D-fructose + NADH + H+;D-sorbitol + NAD+ = D-fructose + NADH + H+;L-arabinose + NADH = L-arabitol + NAD+;D-galactose + NADH = dulcitol + NAD+;L-threitol + NAD+ = L-erythrulose + NADH + H+;D-sorbitol + NADH + H+ = D-fructose + NADH + H+;D-sorbitol + NAD+ = L-sorbose + NADH + H+" "L-iditol + NAD(+) => L-sorbopyranose + H(+) + NADH;L-sorbopyranose + H(+) + NADH => L-iditol + NAD(+)" "xylitol + NAD+ = D-xylulose + NADH + H+;L-iditol + NAD+ = L-sorbose + NADH + H+;ribitol + NAD+ = D-ribulose + NADH + H+;D-mannitol + NAD+ = D-fructose + NADH + H+;D-sorbitol + NAD+ = D-fructose + NADH + H+;L-arabinose + NADH = L-arabitol + NAD+;D-galactose + NADH = dulcitol + NAD+;L-threitol + NAD+ = L-erythrulose + NADH + H+;D-sorbitol + NADH + H+ = D-fructose + NADH + H+;D-sorbitol + NAD+ = L-sorbose + NADH + H+" "D-sorbitol + NAD+ => keto-D-fructose + NADH + H+;L-iditol + NAD+ = keto-L-sorbose + NADH + H+" "D-Sorbitol + NAD+ <=> D-Fructose + NADH + H+;Xylitol + NAD+ <=> D-Xylulose + NADH + H+" 3 out of 5 L-iditol + NAD(+) = L-sorbose + NADH. "D-sorbitol + NAD+ => keto-D-fructose + NADH + H+;L-iditol + NAD+ = keto-L-sorbose + NADH + H+" YES Pentose and glucuronate interconversions pathway from kegg H527 "Pentose and glucuronate interconversions;Fructose and mannose metabolism;Metabolic pathways" sorbitol degradation "Pentose and glucuronate interconversions;path:map00040;Fructose and mannose metabolism;path:map00051;Metabolic pathways;path:map01100" -335 YDR009W "Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication" NA Transcriptional regulator The GAL3 regulatory function is required for rapid induction of the galactose system. At normal induction, galactose in the presence of the GAL3 protein may lead to the induction of the GAL genes, including GAL1. Then the galactokinase protein (GAL1) in the presence of galactose may reinforce the induction leading to a higher expression level. Upon depletion of galactose, the inducing activity of the galactokinase protein may decrease, after which transcription of the GAL genes, including GAL1, may decrease. NA Protein GAL3 "GAL3; transcriptional regulator GAL3" 2.7.1.6 GALactose metabolism GALK1 phosphorylates Gal to Gal1P NA NA NA NA NA ATP + alpha-D-Galactose <=> ADP + alpha-D-Galactose 1-phosphate GALK1 phosphorylates Gal to Gal1P 4 out of 5 NA ATP + alpha-D-Galactose <=> ADP + alpha-D-Galactose 1-phosphate YES Galactose metabolism pathway from kegg NA NA NA "Galactose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways" NA Galactose catabolism NA "nucleus;cytoplasm" -337 YDR020C "Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases" 2.7.1.48 Putative protein of unknown function Putative uridine kinase identified in a screen for mutants with increased levels of rDNA transcription. {ECO:0000269|PubMed:19270272}. 2.7.1.48 Putative uridine kinase DAS2 (EC 2.7.1.48) (DST1-delta 6-azauracil sensitivity protein 2) (Regulator of rDNA transcription 3) "DAS2, RRT3; putative uridine kinase DAS2" uridine kinase "ATP + uridine => ADP + H(+) + UMP;ADP + H(+) + UMP => ATP + uridine" "ATP + CMP = ADP + CDP;ATP + uridine = ADP + UMP;ATP + cytidine = ADP + CMP;dATP + cytidine = dADP + CMP;dUTP + cytidine = dUDP + CMP;dCTP + cytidine = dCDP + CMP;GTP + uridine = UMP + GDP;GTP + cytidine = CMP + GDP;ITP + uridine = IDP + UMP;ATP + 5-fluorouridine = ADP + 5-fluorouridine 5'-monophosphate;dATP + uridine = dADP + UMP;dGTP + uridine = dGDP + UMP;dUTP + uridine = dUDP + UMP;dCTP + uridine = dCDP + UMP;dTTP + uridine = dTDP + UMP;UTP + cytidine = UDP + cytidine 5'-phosphate;ITP + cytidine = IDP + CMP;UTP + Uridine <=> UDP + UMP;dGTP + Cytidine <=> dGDP + CMP;dTTP + Cytidine <=> dTDP + CMP;ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine = ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine 5'-phosphate;ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine = ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine 5'-phosphate" "ATP + uridine => ADP + H(+) + UMP;ADP + H(+) + UMP => ATP + uridine" "ATP + CMP = ADP + CDP;ATP + uridine = ADP + UMP;ATP + cytidine = ADP + CMP;dATP + cytidine = dADP + CMP;dUTP + cytidine = dUDP + CMP;dCTP + cytidine = dCDP + CMP;GTP + uridine = UMP + GDP;GTP + cytidine = CMP + GDP;ITP + uridine = IDP + UMP;ATP + 5-fluorouridine = ADP + 5-fluorouridine 5'-monophosphate;dATP + uridine = dADP + UMP;dGTP + uridine = dGDP + UMP;dUTP + uridine = dUDP + UMP;dCTP + uridine = dCDP + UMP;dTTP + uridine = dTDP + UMP;UTP + cytidine = UDP + cytidine 5'-phosphate;ITP + cytidine = IDP + CMP;UTP + Uridine <=> UDP + UMP;dGTP + Cytidine <=> dGDP + CMP;dTTP + Cytidine <=> dTDP + CMP;ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine = ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine 5'-phosphate;ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine = ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine 5'-phosphate" "uridine + ATP => UMP + ADP + H+;uridine + GTP => UMP + GDP + H+" 4 out of 5 "ATP + uridine = ADP + UMP.; ATP + cytidine = ADP + CMP." "uridine + ATP => UMP + ADP + H+;uridine + GTP => UMP + GDP + H+" YES Pyrimidine metabolism pathway from kegg "E28;H578;H1022" "PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1." pyrimidine ribonucleosides salvage I // salvage pathways of pyrimidine ribonucleotides "Pyrimidine metabolism;path:map00240;Drug metabolism - other enzymes;path:map00983;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -339 YDR036C "3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis" 3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:14566057, PubMed:25609543, PubMed:28154081). mS47 has enzymatic activity in vitro, and is able to catalyze the specific hydrolysis of 3-hydroxyisobutyryl-CoA (HIBYL-CoA). However, because the turnover rate of mS47/EHD3 is only a fraction of that of the homologous mammalian enzyme, the physiological function of this activity remains unclear (PubMed:12697341). Has an indirect role in endocytic membrane trafficking (PubMed:11378903). {ECO:0000269|PubMed:11378903, ECO:0000269|PubMed:12697341, ECO:0000305|PubMed:14566057, ECO:0000305|PubMed:25609543, ECO:0000305|PubMed:28154081}. 3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H) (Mitochondrial small ribosomal subunit protein mS47) "EHD3; Ehd3p" 3.1.2.4 EHD3 beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA "3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+);3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O" "3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate;(S)-3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + (S)-3-hydroxy-2-methylpropanoate;L-3-hydroxybutyryl-CoA + H2O = CoA + L-3-hydroxybutyrate;3-hydroxypropanoyl-CoA + H2O = CoA + 3-hydroxypropanoate" "3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+);3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O" "3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate;(S)-3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + (S)-3-hydroxy-2-methylpropanoate;L-3-hydroxybutyryl-CoA + H2O = CoA + L-3-hydroxybutyrate;3-hydroxypropanoyl-CoA + H2O = CoA + 3-hydroxypropanoate" "3-Hydroxypropanoate + CoA <=> 3-Hydroxypropionyl-CoA + H2O;(S)-3-Hydroxyisobutyryl-CoA + H2O <=> CoA + (S)-3-Hydroxyisobutyrate" 4 out of 5 3-hydroxy-2-methylpropanoyl-CoA + H(2)O = CoA + 3-hydroxy-2-methylpropanoate. {ECO:0000269|PubMed:12697341}. 3-hydroxy-2-methylpropanoyl-CoA + H2O <=> 3-hydroxy-2-methylpropanoate + CoA + H(+) YES valine, leucine and isoleucine metabolism "pathway from kegg; Valine, leucine and isoleucine degradation was changed into Valine, leucine and isoleucine metabolism based on yeast7.7; reaction from rhea" H13 "Valine, leucine and isoleucine degradation;beta-Alanine metabolism;Propanoate metabolism;Metabolic pathways;Carbon metabolism" Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation;path:map00280;beta-Alanine metabolism;path:map00410;Propanoate metabolism;path:map00640;Metabolic pathways;path:map01100" mitochondrion "mitochondrion;cytoplasm" mitochondrion -340 YDR038C "Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family" 3.6.3.7 Protein with similarity to P-type ATPase sodium pumps This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithium ions to allow salt tolerance. {ECO:0000250}. 3.6.3.7 Sodium transport ATPase 5 (EC 3.6.3.7) "ENA5; putative Na(+)-exporting P-type ATPase ENA5" Exitus NAtru (Latin, \exit sodium\) "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ 3 out of 5 ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out). Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ YES sodium transport E586 NA cell envelope cell envelope cell envelope -341 YDR039C "P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux" 3.6.3.7 P-type ATPase sodium pump This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithiums ions to allow salt tolerance. {ECO:0000269|PubMed:7664728, ECO:0000269|PubMed:8437581}. 3.6.3.7 Sodium transport ATPase 2 (EC 3.6.3.7) "ENA2; Na(+)-exporting P-type ATPase ENA2" 3.6.3.7 Exitus NAtru (Latin, \exit sodium\) "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ 5 out of 5 ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out). Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ YES sodium transport E586 NA cell envelope "mitochondrion;cell envelope" cell envelope -342 YDR040C "P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance" 3.6.3.7 P-type ATPase sodium pump This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3. {ECO:0000269|PubMed:7664728, ECO:0000269|PubMed:9315618}. 3.6.3.7 Sodium transport ATPase 1 (EC 3.6.3.7) "ENA1, HOR6, PMR2; Na(+)/Li(+)-exporting P-type ATPase ENA1" Exitus NAtru (Latin, \exit sodium\) "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ 5 out of 5 ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out). Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ YES sodium transport E586 NA cell envelope "vacuole;cell envelope" cell envelope -343 YDR045C "RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS" RNA polymerase III subunit C11 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in Pol III transcription reinitiation and RNA cleavage during transcription termination. {ECO:0000269|PubMed:16362040}. DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerases III 12.5 kDa polypeptide) (RNA polymerase III subunit C11) "RPC11; DNA-directed RNA polymerase III core subunit RPC11" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus -344 YDR051C "Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel" 3.1.3.- Acid phosphatase Metal-independent, broad-range acid phosphatase. Involved, either directly or indirectly, in the bidirectional transport of sterols between the endoplasmic reticulum and the plasma membrane. {ECO:0000269|PubMed:19060182, ECO:0000269|PubMed:19753119}. 3.1.3.- Broad-range acid phosphatase DET1 (EC 3.1.3.-) (Decreased ergosterol transport protein 1) "DET1; acid phosphatase DET1" Decreased Ergosterol Transport 2-phospho-D-glycerate <=> 3-phospho-D-glycerate 4 out of 5 NA sterols <=> sterols YES sterols transport transport of sterols "E88;E587;H1052" gluconeogenesis // glycolysis NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -353 YDR093W "Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication" 3.6.3.1 Aminophospholipid translocase (flippase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles. {ECO:0000269|PubMed:12221123}. 3.6.3.1 Phospholipid-transporting ATPase DNF2 (EC 3.6.3.1) (Flippase DNF2) "DNF2; aminophospholipid-translocating P4-type ATPase DNF2" 3.6.3.1 Drs2 Neo1 Family "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ YES phospholipids transport "E586;H449" Ion transport by P-type ATPases NA cell envelope "Golgi membrane;endoplasmic reticulum;cell envelope" cell envelope -354 YDR105C "Vacuolar membrane protein of unknown function; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance" Vacuolar membrane protein of unknown function Membrane protein TMS1 "TMS1; Tms1p" Unknown "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane;SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane" "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane;SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane" 2 out of 5 NA L-ser <=> L-ser YES L-ser transport Serine biosynthesis NA vacuole -356 YDR111C "Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, that arose from the whole genome duplication" 2.6.1.2 Catalytically inactive alanine transaminase 2.6.1.2 Probable alanine aminotransferase (EC 2.6.1.2) (Glutamate pyruvate transaminase) (GPT) (Glutamic--alanine transaminase) (Glutamic--pyruvic transaminase) "ALT2; alanine transaminase ALT2" 2.6.1.2 transaminase "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2];alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2];alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT];pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT]" "2-oxoglutarate + L-alanine => L-glutamate + pyruvate;L-glutamate + pyruvate => 2-oxoglutarate + L-alanine" "L-alanine + 2-oxoglutarate = pyruvate + L-glutamate;serine + 2-oxoglutarate = 3-hydroxy-2-oxopropanoate + glutamate;2-oxoglutarate + 6-aminohexanoate = glutamate + 6-oxohexanoate;D-alanine + 2-oxoglutarate = pyruvate + D-glutamate" "2-oxoglutarate + L-alanine => L-glutamate + pyruvate;L-glutamate + pyruvate => 2-oxoglutarate + L-alanine" "L-alanine + 2-oxoglutarate = pyruvate + L-glutamate;serine + 2-oxoglutarate = 3-hydroxy-2-oxopropanoate + glutamate;2-oxoglutarate + 6-aminohexanoate = glutamate + 6-oxohexanoate;D-alanine + 2-oxoglutarate = pyruvate + D-glutamate" 2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate L-Alanine + 2-Oxoglutarate <=> Pyruvate + L-Glutamate 3 out of 5 L-alanine + 2-oxoglutarate = pyruvate + L-glutamate. L-Alanine + 2-Oxoglutarate <=> Pyruvate + L-Glutamate YES Alanine, aspartate and glutamate metabolism pathway from kegg "E42;H82" "PATHWAY: Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1." "Arginine biosynthesis;Alanine, aspartate and glutamate metabolism;Metabolic pathways;Carbon metabolism;2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids" alanine degradation III // alanine biosynthesis Amino acid synthesis and interconversion (transamination) "Arginine biosynthesis;path:map00220;Alanine, aspartate and glutamate metabolism;path:map00250;Carbon fixation in photosynthetic organisms;path:map00710;Metabolic pathways;path:map01100;Microbial metabolism in diverse environments;path:map01120" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -358 YDR121W "Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization" 2.7.7.7 Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. Also functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex. {ECO:0000269|PubMed:11024162, ECO:0000269|PubMed:11081629, ECO:0000269|PubMed:11238944, ECO:0000269|PubMed:11533234, ECO:0000269|PubMed:12124389, ECO:0000269|PubMed:14673157}. 2.7.7.7 DNA polymerase epsilon subunit D (EC 2.7.7.7) (DNA polymerase II subunit D) "DPB4; DNA polymerase epsilon noncatalytic subunit" 2.7.7.7 DNA Polymerase B (II) subunit "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus -365 YDR156W RNA polymerase I subunit A14 RNA polymerase I subunit A14 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. RPA14 seems to play a role in the stability of subunits RPO26 and RPA43. In vitro, the RPA14-RPA43 subcomplex binds single-stranded RNA. {ECO:0000269|PubMed:12888498, ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerase I subunit RPA14 (A14) (DNA-directed RNA polymerase I 14 kDa polypeptide) "RPA14; DNA-directed RNA polymerase I subunit RPA14" RNA Polymerase A a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus -370 YDR231C "Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase" NA Mitochondrial inner membrane protein Involved in the assembly of the cytochrome oxidase complex. Required for the maturation and subsequent assembly of the mitochondrially encoded COX2, the precursor of subunit 2 of cytochrome oxidase. {ECO:0000269|PubMed:10671482}. NA Cytochrome c oxidase protein 20, mitochondrial "COX20; Cox20p" NA Cytochrome c OXidase NA NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 4 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA NA aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -371 YDR242W Putative amidase 3.5.1.4 Putative amidase 3.5.1.4 Probable amidase (EC 3.5.1.4) "AMD2; putative amidase" 3.5.1.4 amidase "FAAH hydrolyses AEA to AA and ETA;FAAH2 hydrolyses AEA to AA and ETA" "a monocarboxylic acid amide + H2O => a monocarboxylate + NH4(+);a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O;H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+);(indol-3-yl)acetate + NH4(+) => H2O + indole-3-acetamide;acetamide + H2O => acetate + NH4(+);acetate + NH4(+) => acetamide + H2O" "a monocarboxylic acid amide + H2O = a monocarboxylate + NH3;anandamide + H2O = arachidonic acid + ethanolamine;pyrazinamide + H2O = pyrazinoic acid + NH3;an acetic ester + H2O = an alcohol + acetate;indole-3-acetamide + H2O = indole-3-acetic acid + NH3;propionamide + H2O = propionic acid + NH3;phenylacetamide = phenylacetic acid + NH3;benzamide + H2O = benzoic acid + NH3;acetamide + H2O = acetic acid + NH3;acrylamide + H2O = acrylic acid + NH3;4-Guanidinobutanamide + H2O <=> 4-Guanidinobutanoate + Ammonia;ethyl propionate + H2O = ethanol + propionate;glutaramic acid + H2O = glutaric acid + NH3;2-hydroxyisobutyramide + H2O = 2-hydroxyisobutanoate + ammonium;2-arylpropionic amide + H2O = S-2-arylpropionic acid + NH3;isobutyramide + H2O = isobutyrate + NH3;2-chloropropionamide + H2O = 2-chloropropionate + NH3;butyramide + H2O = n-butyrate + NH3;2 indole-3-acetonitrile + 3 H2O = indole-3-acetamide + indole-3-acetic acid + NH3;N-methylpropionamide + H2O = methylamine + propionate;DL-lactamide + H2O = DL-lactate + NH3;pivalamide + H2O = pivalate + NH3;propionohydrazide + H2O = hydrazine + propionate;N-oleoylethanolamine + H2O = oleic acid + ethanolamine;2-arachidonoylglycerol + H2O = arachidonic acid + glycerol;N-methylacetamide + H2O = methylamine + acetate;acetanilide + H2O = acetate + aniline;acetohydrazide + H2O = hydrazine + acetate;acetohydroxamate + H2O = hydroxylamine + acetate;monoamidated dicarboxylate + H2O = dicarboxylate + ammonia;ethyl acrylate + H2O = acrylate + ethanol;1-naphthaleneacetamide + H2O = 1-naphthaleneacetic acid + NH3;(R)-(+)-2-chloropropionamide + H2O = (+)-2-chloropropionic acid + NH3;(S)-(-)-2-chloropropionamide + H2O = (-)-2-chloropropionic acid + NH3;propionohydroxamate + H2O = hydroxylamine + propionate;hydroxylamine + acylamide = acylhydroxamate + NH3;carboxylic acid ester + hydroxylamine = N-hydroxy-carboxylic acid amide + alcohol;carboxylic acid + hydroxylamine = N-hydroxy-carboxylic acid amide + H2O;phenetidine + acetate = phenacetin + H2O;3,3,3-trifluoro-2-hydroxy-2-methylpropanamide + H2O = 3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid + NH3;ketoprofen amide = 2-(3-benzoylphenyl)propionic acid + NH3" "a monocarboxylic acid amide + H2O => a monocarboxylate + NH4(+);a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O;H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+);(indol-3-yl)acetate + NH4(+) => H2O + indole-3-acetamide;acetamide + H2O => acetate + NH4(+);acetate + NH4(+) => acetamide + H2O" "a monocarboxylic acid amide + H2O = a monocarboxylate + NH3;anandamide + H2O = arachidonic acid + ethanolamine;pyrazinamide + H2O = pyrazinoic acid + NH3;an acetic ester + H2O = an alcohol + acetate;indole-3-acetamide + H2O = indole-3-acetic acid + NH3;propionamide + H2O = propionic acid + NH3;phenylacetamide = phenylacetic acid + NH3;benzamide + H2O = benzoic acid + NH3;acetamide + H2O = acetic acid + NH3;acrylamide + H2O = acrylic acid + NH3;4-Guanidinobutanamide + H2O <=> 4-Guanidinobutanoate + Ammonia;ethyl propionate + H2O = ethanol + propionate;glutaramic acid + H2O = glutaric acid + NH3;2-hydroxyisobutyramide + H2O = 2-hydroxyisobutanoate + ammonium;2-arylpropionic amide + H2O = S-2-arylpropionic acid + NH3;isobutyramide + H2O = isobutyrate + NH3;2-chloropropionamide + H2O = 2-chloropropionate + NH3;butyramide + H2O = n-butyrate + NH3;2 indole-3-acetonitrile + 3 H2O = indole-3-acetamide + indole-3-acetic acid + NH3;N-methylpropionamide + H2O = methylamine + propionate;DL-lactamide + H2O = DL-lactate + NH3;pivalamide + H2O = pivalate + NH3;propionohydrazide + H2O = hydrazine + propionate;N-oleoylethanolamine + H2O = oleic acid + ethanolamine;2-arachidonoylglycerol + H2O = arachidonic acid + glycerol;N-methylacetamide + H2O = methylamine + acetate;acetanilide + H2O = acetate + aniline;acetohydrazide + H2O = hydrazine + acetate;acetohydroxamate + H2O = hydroxylamine + acetate;monoamidated dicarboxylate + H2O = dicarboxylate + ammonia;ethyl acrylate + H2O = acrylate + ethanol;1-naphthaleneacetamide + H2O = 1-naphthaleneacetic acid + NH3;(R)-(+)-2-chloropropionamide + H2O = (+)-2-chloropropionic acid + NH3;(S)-(-)-2-chloropropionamide + H2O = (-)-2-chloropropionic acid + NH3;propionohydroxamate + H2O = hydroxylamine + propionate;hydroxylamine + acylamide = acylhydroxamate + NH3;carboxylic acid ester + hydroxylamine = N-hydroxy-carboxylic acid amide + alcohol;carboxylic acid + hydroxylamine = N-hydroxy-carboxylic acid amide + H2O;phenetidine + acetate = phenacetin + H2O;3,3,3-trifluoro-2-hydroxy-2-methylpropanamide + H2O = 3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid + NH3;ketoprofen amide = 2-(3-benzoylphenyl)propionic acid + NH3" "4-guanidinobutyramide + H2O = ammonium + 4-guanidinobutanoate;a monocarboxylic acid amide + H2O = a monocarboxylate + ammonium;acrylamide + H2O = ammonium + acrylate;indole-3-acetamide + H2O = indole-3-acetate + ammonium;nicotinamide + H2O => ammonium + nicotinate" "2-Phenylacetamide + H2O <=> Phenylacetic acid + Ammonia;(Indol-3-yl)acetamide + H2O <=> Indole-3-acetate + Ammonia;4-Guanidinobutanamide + H2O <=> 4-Guanidinobutanoate + Ammonia;Monocarboxylic acid amide + H2O <=> Carboxylate + Ammonia;Acrylic acid + Ammonia <=> Acrylamide + H2O;Benzamide + H2O <=> Benzoate + Ammonia" 2 out of 5 A monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3). "2-Phenylacetamide + H2O <=> Phenylacetic acid + Ammonia;(Indol-3-yl)acetamide + H2O <=> Indole-3-acetate + Ammonia;4-Guanidinobutanamide + H2O <=> 4-Guanidinobutanoate + Ammonia;Monocarboxylic acid amide + H2O <=> Carboxylate + Ammonia;Acrylic acid + Ammonia <=> Acrylamide + H2O;Benzamide + H2O <=> Benzoate + Ammonia" YES "Arginine and proline metabolism; Phenylalanine metabolism; Tryptophan metabolism" pathway from kegg H1175 "Arginine and proline metabolism;Phenylalanine metabolism;Tryptophan metabolism" NAD salvage pathway Arachidonic acid metabolism "Arginine and proline metabolism;path:map00330;Phenylalanine metabolism;path:map00360;Tryptophan metabolism;path:map00380;Aminobenzoate degradation;path:map00627;Styrene degradation;path:map00643;Microbial metabolism in diverse environments;path:map01120" -374 YDR248C "Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1" 2.7.1.12 Putative gluconokinase 2.7.1.12 Probable gluconokinase (EC 2.7.1.12) (Gluconate kinase) gluconokinase 2.7.1.12 putative gluconokinase "D-gluconate + ATP => 6-phospho-D-gluconate + ADP + H(+);6-phospho-D-gluconate + ADP + H(+) => D-gluconate + ATP" "ATP + D-gluconate = ADP + 6-phospho-D-gluconate;ATP + a protein = ADP + a phosphoprotein" "D-gluconate + ATP => 6-phospho-D-gluconate + ADP + H(+);6-phospho-D-gluconate + ADP + H(+) => D-gluconate + ATP" "ATP + D-gluconate = ADP + 6-phospho-D-gluconate;ATP + a protein = ADP + a phosphoprotein" ATP + D-gluconate => D-gluconate 6-phosphate + ADP + H+ ATP + D-Gluconic acid <=> ADP + 6-Phospho-D-gluconate 3 out of 5 ATP + D-gluconate = ADP + 6-phospho-D-gluconate. D-gluconate + ATP <=> 6-phospho-D-gluconate + ADP + H(+) YES Pentose phosphate pathway "pathway from kegg; reaction from rhea" E577 "PATHWAY: Carbohydrate acid metabolism; D-gluconate degradation." "Pentose phosphate pathway;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism" D-gluconate degradation "Pentose phosphate pathway;path:map00030;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" cytoplasm "vacuole;cytoplasm" cytoplasm -377 YDR270W "Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant" 3.6.3.54 Cu(+2)-transporting P-type ATPase Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles. 3.6.3.54 Copper-transporting ATPase (EC 3.6.3.54) (Cu(2+)-ATPase) "CCC2; Cu(2+)-transporting P-type ATPase CCC2" 3.6.3.54 Cross-Complements Ca(2+) phenotype of csg1 ATP7B transports cytosolic Cu2+ to Golgi lumen "ATP + Cu(+)(in) + H2O => ADP + Cu(+)(out) + H(+) + phosphate;ADP + Cu(+)(out) + H(+) + phosphate => ATP + Cu(+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Cu+[side 1] = ADP + phosphate + Cu+[side 2];ATP + a protein = ADP + a phosphoprotein" "ATP + Cu(+)(in) + H2O => ADP + Cu(+)(out) + H(+) + phosphate;ADP + Cu(+)(out) + H(+) + phosphate => ATP + Cu(+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Cu+[side 1] = ADP + phosphate + Cu+[side 2];ATP + a protein = ADP + a phosphoprotein" Cu2+[in] + ATP + H2O => Cu2+[out] + ADP + phosphate + H+ ATP + H2O <=> ADP + Orthophosphate ATP7B transports cytosolic Cu2+ to Golgi lumen 5 out of 5 ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2). Cu2+[in] + ATP + H2O => Cu2+[out] + ADP + phosphate + H+ YES Cu2+ transport pathway from reactome "E521;E586" Ion transport by P-type ATPases NA Golgi "Golgi;cell envelope" Golgi -383 YDR307W "Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation" 2.4.1.109 Putative protein mannosyltransferase similar to Pmt1p Probable protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. {ECO:0000250|UniProtKB:P33775}. 2.4.1.109 Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7 (EC 2.4.1.109) "PMT7; putative dolichyl-phosphate-mannose--protein mannosyltransferase" 2.4.1.109 PMT7 "[protein]-L-serine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => [protein]-L-serine + dolichyl beta-D-mannosyl phosphate;[protein]-L-threonine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+) => [protein]-L-threonine + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + alpha-D-Man-1-Ser/Thr;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein];dolichyl beta-D-mannosyl phosphate + [protein]-(L-serine/L-threonine) = dolichyl phosphate + [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+;dolichyl phosphate D-mannose + protein AN5660 = dolichyl phosphate + O-D-mannosylprotein;dolichyl phosphate D-mannose + alpha-dystroglycan = dolichyl phosphate + O-D-mannosyl-[alpha-dystroglycan];dolichyl phosphate D-mannose + protein Aga2 = dolichyl phosphate + O-D-mannosylprotein Aga2;dolichyl phosphate D-mannose + protein Bar1 = dolichyl phosphate + O-D-mannosylprotein Bar1;dolichyl phosphate D-mannose + protein chitinase 1 = dolichyl phosphate + O-D-mannosylprotein chitinase 1;dolichyl phosphate D-mannose + protein Ggp1/Gas1 = dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1;dolichyl phosphate D-mannose + protein Kex2 = dolichyl phosphate + O-D-mannosylprotein Kex2;dolichyl phosphate D-mannose + protein Kre9 = dolichyl phosphate + O-D-mannosylprotein Kre9;dolichyl phosphate D-mannose + protein Pir2/hsp150 = dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150;dolichyl phosphate D-mannose + ribonuclease 2 = dolichyl phosphate + ribonuclease 2-D-mannose;dolichyl phosphate D-mannose + glucoamylase I = dolichyl phosphate + O-D-mannosyl glucoamylase I;dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein" "[protein]-L-serine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => [protein]-L-serine + dolichyl beta-D-mannosyl phosphate;[protein]-L-threonine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+) => [protein]-L-threonine + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + alpha-D-Man-1-Ser/Thr;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein];dolichyl beta-D-mannosyl phosphate + [protein]-(L-serine/L-threonine) = dolichyl phosphate + [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+;dolichyl phosphate D-mannose + protein AN5660 = dolichyl phosphate + O-D-mannosylprotein;dolichyl phosphate D-mannose + alpha-dystroglycan = dolichyl phosphate + O-D-mannosyl-[alpha-dystroglycan];dolichyl phosphate D-mannose + protein Aga2 = dolichyl phosphate + O-D-mannosylprotein Aga2;dolichyl phosphate D-mannose + protein Bar1 = dolichyl phosphate + O-D-mannosylprotein Bar1;dolichyl phosphate D-mannose + protein chitinase 1 = dolichyl phosphate + O-D-mannosylprotein chitinase 1;dolichyl phosphate D-mannose + protein Ggp1/Gas1 = dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1;dolichyl phosphate D-mannose + protein Kex2 = dolichyl phosphate + O-D-mannosylprotein Kex2;dolichyl phosphate D-mannose + protein Kre9 = dolichyl phosphate + O-D-mannosylprotein Kre9;dolichyl phosphate D-mannose + protein Pir2/hsp150 = dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150;dolichyl phosphate D-mannose + ribonuclease 2 = dolichyl phosphate + ribonuclease 2-D-mannose;dolichyl phosphate D-mannose + glucoamylase I = dolichyl phosphate + O-D-mannosyl glucoamylase I;dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein" a dolichyl beta-D-mannosyl phosphate + a [protein]-(L-serine/L-threonine) => a dolichyl phosphate + a [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+ "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + G13027;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein]" 3 out of 5 Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein. {ECO:0000250|UniProtKB:P33775}. "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + G13027;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein]" YES Mannose type O-glycan biosynthesis "pathway from kegg; ; reaction from kegg; dolp_L[c] + M02645[c] <=> dolmanp_L[c] + Ser_Gly_Ala_X_Gly[c] from recon3" H1179 "PATHWAY: Protein modification; protein glycosylation. {ECO:0000305}." "Other types of O-glycan biosynthesis;Mannose type O-glycan biosynthesis;Metabolic pathways" protein O-mannosylation I (yeast) "Other types of O-glycan biosynthesis;path:map00514;Mannose type O-glycan biosynthesis;path:map00515;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -386 YDR352W "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter" Putative vacuolar membrane transporter for cationic amino acids May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. {ECO:0000269|PubMed:23169667}. Probable vacuolar amino acid transporter YPQ2 (PQ-loop repeat-containing protein 2) "YPQ2; Ypq2p" Yeast PQ-loop protein PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 4 out of 5 NA " L-Arg <=> L-Arg; L-His <=> L-His; L-Lys <=> L-Lys" YES "L-Arg transport (from lysosomal lumen to cytosol); L-His transport (from lysosomal lumen to cytosol); L-Lys transport (from lysosomal lumen to cytosol)" cationic amino acids transport Miscellaneous transport and binding events NA vacuolar membrane "vacuole;vacuolar membrane" vacuolar membrane -387 YDR371W "Putative chitinase; functionally complements A. gossypii cts2 mutant sporulation defect" 3.2.1.14 Putative chitinase 3.2.1.14 Sporulation-specific chitinase 2 (EC 3.2.1.14) "CTS2; putative chitinase" 3.2.1.14 ChiTinaSe "CHIA hydrolyses chitin;CHIT1 hydrolyses CHIT to 3xADGP;Exocytosis of tertiary granule lumen proteins;Exocytosis of tertiary granule lumen proteins;Exocytosis of specific granule lumen proteins;Exocytosis of specific granule lumen proteins;Exocytosis of specific granule lumen proteins;Exocytosis of specific granule lumen proteins" "GlcNAc beta(1-4)GlcNAc + H2O = N-acetyl-D-glucosamine + N-acetyl-D-glucosamine;Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin;beta-1,4-Poly-N-acetyl-D-glucosamine(n+2) + H2O <=> Chitobiose + beta-1,4-Poly-N-acetyl-D-glucosamine(n);N,N',N'',N''',N''''-pentaacetylchitopentaose + H2O = N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;solid beta-chitin + H2O = N,N'-diacetylchitobiose;N-acetylglucosamine oligomers + H2O = N-acetylglucosamine;chitosan + H2O = chitosan oligosaccharides;chitopentaose + H2O = chitobiose + chitotriose" "GlcNAc beta(1-4)GlcNAc + H2O = N-acetyl-D-glucosamine + N-acetyl-D-glucosamine;Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin;beta-1,4-Poly-N-acetyl-D-glucosamine(n+2) + H2O <=> Chitobiose + beta-1,4-Poly-N-acetyl-D-glucosamine(n);N,N',N'',N''',N''''-pentaacetylchitopentaose + H2O = N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;solid beta-chitin + H2O = N,N'-diacetylchitobiose;N-acetylglucosamine oligomers + H2O = N-acetylglucosamine;chitosan + H2O = chitosan oligosaccharides;chitopentaose + H2O = chitobiose + chitotriose" "a chitodextrin + n H2O => n N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;chitin + H2O => 2 a chitodextrin" "Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin" 3 out of 5 Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. "Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin" YES Amino sugar and nucleotide sugar metabolism "pathway from kegg; human model: 2 h2o[c] + Chitin[c] -> 3 N-Acetyl-D-Glucosamine[c]" "H142;H1198" "Amino sugar and nucleotide sugar metabolism;Metabolic pathways" "Digestion of dietary carbohydrate;Neutrophil degranulation" "Amino sugar and nucleotide sugar metabolism;path:map00520;Metabolic pathways;path:map01100" "extracellular;cytoplasm" -388 YDR387C "Putative transporter; member of the sugar porter family; non-essential gene; overexpression results in elevated colony sectoring, an indicator of chromosomal instability" Putative transporter Probable metabolite transport protein YDR387C "CIN10; Cin10p" YDR387C "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;HMIT co-transports myo-inositol with a proton;AP-2 directly binds some endocytic cargo" "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;HMIT co-transports myo-inositol with a proton;AP-2 directly binds some endocytic cargo" 3 out of 5 NA "Glc <=> Glc; myo-inositol <=> myo-inositol" YES Glc transport my-inositol transport is not sure, only shown in reactome database. "Cellular hexose transport;Inositol transporters;Cargo recognition for clathrin-mediated endocytosis" NA "vacuole;cell envelope" -389 YDR404C "RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation" RNA polymerase II subunit B16 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II. {ECO:0000269|PubMed:11087726, ECO:0000269|PubMed:15304220, ECO:0000269|PubMed:17875743}. DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (B16) "RPB7; DNA-directed RNA polymerase II subunit RPB7" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA "nucleus;cytoplasm" "nucleus;cytoplasm" "nucleus;cytoplasm" -390 YDR410C "Farnesyl cysteine-carboxyl methyltransferase; mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane" 2.1.1.100 Farnesyl cysteine-carboxyl methyltransferase Mediates C-terminal methylation of the isoprenylated C-terminal cysteine in A-factor mating pheromone and Ras proteins. {ECO:0000269|PubMed:8289819}. 2.1.1.100 Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT) "STE14; protein-S-isoprenylcysteine carboxyl O-methyltransferase" 2.1.1.100 STErile ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins "S-adenosyl-L-methionine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine => S-adenosyl-L-homocysteine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester;S-adenosyl-L-homocysteine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester => S-adenosyl-L-methionine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine" "S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester;[protein] C-terminal S-farnesyl-L-cysteine + S-adenosyl-L-methionine = [protein] C-terminal S-farnesyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester;S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester;S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester" "S-adenosyl-L-methionine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine => S-adenosyl-L-homocysteine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester;S-adenosyl-L-homocysteine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester => S-adenosyl-L-methionine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine" "S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester;[protein] C-terminal S-farnesyl-L-cysteine + S-adenosyl-L-methionine = [protein] C-terminal S-farnesyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester;S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester;S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester" a [protein] C-terminal S-farnesyl-L-cysteine + S-adenosyl-L-methionine => a [protein] C-terminal S-farnesyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine S-Adenosyl-L-methionine + Protein C-terminal S-farnesyl-L-cysteine <=> S-Adenosyl-L-homocysteine + Protein C-terminal S-farnesyl-L-cysteine methyl ester NA 4 out of 5 S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. S-Adenosyl-L-methionine + Protein C-terminal S-farnesyl-L-cysteine <=> S-Adenosyl-L-homocysteine + Protein C-terminal S-farnesyl-L-cysteine methyl ester YES Terpenoid backbone biosynthesis pathway from kegg H1124 NA NA "Terpenoid backbone biosynthesis;Biosynthesis of antibiotics" NA Gamma carboxylation, hypusine formation and arylsulfatase activation "Terpenoid backbone biosynthesis;path:map00900;Biosynthesis of antibiotics;path:map01130" "nucleus;endoplasmic reticulum;endoplasmic reticulum membrane" -391 YDR419W "DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV" 2.7.7.7 DNA polymerase eta DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O(6)-methylguanine, 7,8-dihydro-8-oxoguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts. {ECO:0000269|PubMed:10347143, ECO:0000269|PubMed:10601233, ECO:0000269|PubMed:10713149, ECO:0000269|PubMed:10725365, ECO:0000269|PubMed:10924462, ECO:0000269|PubMed:10932195, ECO:0000269|PubMed:11027270, ECO:0000269|PubMed:11054429, ECO:0000269|PubMed:11062246, ECO:0000269|PubMed:11113193, ECO:0000269|PubMed:11238937, ECO:0000269|PubMed:11545742, ECO:0000269|PubMed:11861920, ECO:0000269|PubMed:12110599, ECO:0000269|PubMed:12665597, ECO:0000269|PubMed:12692307, ECO:0000269|PubMed:12888515, ECO:0000269|PubMed:12899630, ECO:0000269|PubMed:14527996, ECO:0000269|PubMed:15024063, ECO:0000269|PubMed:15157108, ECO:0000269|PubMed:15284331, ECO:0000269|PubMed:15333698, ECO:0000269|PubMed:15520252, ECO:0000269|PubMed:15544332, ECO:0000269|PubMed:15743815, ECO:0000269|PubMed:15779911, ECO:0000269|PubMed:16181813, ECO:0000269|PubMed:16366567, ECO:0000269|PubMed:16387871, ECO:0000269|PubMed:16415180, ECO:0000269|PubMed:16866379, ECO:0000269|PubMed:9409821, ECO:0000269|PubMed:9974380}. 2.7.7.7 DNA polymerase eta (EC 2.7.7.7) (Radiation-sensitive protein 30) "RAD30, DBH1; DNA-directed DNA polymerase eta" 2.7.7.7 RADiation sensitive "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication involved in translesion synthesis during post-replication repair H1117 "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus "nucleus;mitochondrion" nucleus -394 YDR437W "Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis; shares similarity with mammalian PIG-P" 2.4.1.198 Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Involved in cell wall biosynthesis. {ECO:0000269|PubMed:16278447}. 2.4.1.198 Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19 (GPI-GlcNAc transferase complex subunit GPI19) (GPI-GnT subunit GPI19) (EC 2.4.1.198) "GPI19; phosphatidylinositol N-acetylglucosaminyltransferase GPI19" Glycosyl PhosphatidylInositol anchor biosynthesis "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" an L-1-phosphatidyl-inositol + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H+ UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 4 out of 5 UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol. UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES lycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H479;H1129" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;path:map00563;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "nucleus;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -395 YDR440W "Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response" 2.1.1.43 Nucleosomal histone H3-Lys79 methylase Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro). {ECO:0000269|PubMed:11029058, ECO:0000269|PubMed:12097318, ECO:0000269|PubMed:12152067, ECO:0000269|PubMed:12574507, ECO:0000269|PubMed:15292170, ECO:0000269|PubMed:15632126, ECO:0000269|PubMed:16166626, ECO:0000269|PubMed:9755194}. 2.1.1.43 Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Disrupter of telomere silencing protein 1) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) "DOT1, KMT4, PCH1; histone methyltransferase DOT1" 2.1.1.43 Disruptor Of Telomeric silencing "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79);DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79);DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)" "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" a [histone]-L-lysine + S-adenosyl-L-methionine => a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+ "Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine;S-Adenosyl-L-methionine + Histone-L-lysine <=> S-Adenosyl-L-homocysteine + Histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine" 5 out of 5 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. {ECO:0000255|PROSITE-ProRule:PRU00902, ECO:0000269|PubMed:12080090, ECO:0000269|PubMed:12086673, ECO:0000269|PubMed:15292170}. S-adenosyl-L-methionine + L-lysine-[histone] <=> S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone] YES Lysine metabolism "pathway from kegg; reaction from uniprot; Lysine degradation was changed into lysine metabolism based on yeast 7.7" "H372;H974" Lysine degradation PKMTs methylate histone lysines "Lysine degradation;path:map00310" nucleus nucleus nucleus -396 YDR441C "Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication" 2.4.2.7 Potential adenine phosphoribosyltransferase Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. May lack catalytic activity. 2.4.2.7 Adenine phosphoribosyltransferase 2 (APRT 2) (EC 2.4.2.7) "APT2; adenine phosphoribosyltransferase APT2" 2.4.2.7 adenine phosphoribosyltransferase "Exocytosis of secretory granule lumen proteins;Exocytosis of secretory granule lumen proteins;Adenine + PRPP => AMP + PPi" "AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine;5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate" "AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate;5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate = 5-amino-4-imidazolecarboxamide ribotide + diphosphate;5-phospho-alpha-D-ribose 1-diphosphate + guanine = GMP + diphosphate" "AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine;5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate" "AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate;5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate = 5-amino-4-imidazolecarboxamide ribotide + diphosphate;5-phospho-alpha-D-ribose 1-diphosphate + guanine = GMP + diphosphate" 5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate "AMP + Diphosphate <=> Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate;GMP + Diphosphate <=> Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate;1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Diphosphate <=> 5-Amino-4-imidazolecarboxyamide + 5-Phospho-alpha-D-ribose 1-diphosphate" Adenine + PRPP => AMP + PPi 3 out of 5 AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. 5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate YES Purine metabolism pathway from kegg "E227;E613;H62" "PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1." "Purine metabolism;Metabolic pathways" superpathway of purine nucleosides salvage // salvage pathways of adenine, hypoxanthine and their nucleosides // adenine and adenosine salvage IV "Neutrophil degranulation;Purine salvage" "Purine metabolism;path:map00230;Metabolic pathways;path:map01100" cytoplasm cytoplasm cytoplasm -397 YDR452W "Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress" "3.6.1.10;3.6.1.11" Dual endo- and exopolyphosphatase with a role in phosphate metabolism Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths both by cleaving phosphate from the chain end and by fragmenting long-chain polymers into shorter ones. The limited digestion products are 1 and 3 P(i) residues (PubMed:11102525, PubMed:11447286, PubMed:15170373, PubMed:15342119, PubMed:15792812, PubMed:8900207, Ref.16). Also releases phosphate from dATP. dATP phosphohydrolase activity is about 7-fold lower than the exopolyphosphatase activity (Ref.16). {ECO:0000269|PubMed:11102525, ECO:0000269|PubMed:11447286, ECO:0000269|PubMed:15170373, ECO:0000269|PubMed:15342119, ECO:0000269|PubMed:15792812, ECO:0000269|PubMed:8900207, ECO:0000269|Ref.16}. "3.6.1.10; 3.6.1.-; 3.6.1.11" Endopolyphosphatase (EC 3.6.1.10) (Deoxyadenosine triphosphate phosphohydrolase) (dATP phosphohydrolase) (EC 3.6.1.-) (Exopolyphosphatase) (EC 3.6.1.11) (Phosphate metabolism protein 5) "PPN1, PHM5; endopolyphosphatase" 3.6.1.10 PPN1 Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) "n H2O + polyphosphaten+1 => n H(+) + (n+1) phosphate;n H(+) + (n+1) phosphate => n H2O + polyphosphaten+1;H2O + polyphosphaten => H(+) + phosphate + polyphosphaten-1;H(+) + phosphate + polyphosphaten-1 => H2O + polyphosphaten" "polyphosphate + n H2O = (n+1) oligophosphate;(polyphosphate)n + H2O = (polyphosphate)n-1 + phosphate;guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;inosine tetraphosphate + H2O = ITP + phosphate" "n H2O + polyphosphaten+1 => n H(+) + (n+1) phosphate;n H(+) + (n+1) phosphate => n H2O + polyphosphaten+1;H2O + polyphosphaten => H(+) + phosphate + polyphosphaten-1;H(+) + phosphate + polyphosphaten-1 => H2O + polyphosphaten" "polyphosphate + n H2O = (n+1) oligophosphate;(polyphosphate)n + H2O = (polyphosphate)n-1 + phosphate;guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;inosine tetraphosphate + H2O = ITP + phosphate" (polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate NA Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) 5 out of 5 "Polyphosphate + n H(2)O = (n+1) oligophosphate. {ECO:0000269|PubMed:15792812}.; (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate. {ECO:0000269|PubMed:15170373}.; dATP + H(2)O = dADP + phosphate. {ECO:0000269|Ref.16}." "Polyphosphate + n H(2)O <=> (n+1) oligophosphate; (Polyphosphate)(n) + H(2)O <=> (polyphosphate)(n-1) + phosphate; dATP + H(2)O <=> dADP + phosphate" YES other The choose reactions should be: Polyphosphate + n H(2)O <=> (n+1) oligophosphate "NA;NA;NA" NA NA NA NA Glycosphingolipid metabolism "NA;NA;NA" "vacuolar membrane;cytoplasm" "vacuole;nucleus;cytoplasm;vacuolar membrane" "vacuolar membrane;cytoplasm" -398 YDR456W "Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism" Na+/H+ and K+/H+ exchanger Endosomal/prevacuolar electroneutral Na(+)/H(+) exchanger which mediates intracellular sequestration of Na(+) cations, regulates vacuolar pH and contributes to osmotolerance following sudden exposure to hyperosmotic media. Contributes also to the postdiauxic/stationary phase resistance to osmotic stress and allows for the continued growth of cells until the acquired osmotolerance response can occur. Involved in hygromycin resistance probably through its influence on the electrochemical proton gradient affecting secondarily the entrance of hygromycin. Mediates pH-dependent vesicle trafficking out of the endosome. Contributes to K(+) sequestration and homeostasis. {ECO:0000269|PubMed:10589731, ECO:0000269|PubMed:10998367, ECO:0000269|PubMed:11102523, ECO:0000269|PubMed:14610088, ECO:0000269|PubMed:1493335, ECO:0000269|PubMed:15635088, ECO:0000269|PubMed:15659172, ECO:0000269|PubMed:16671892, ECO:0000269|PubMed:17588950, ECO:0000269|PubMed:18378800, ECO:0000269|PubMed:18799619, ECO:0000269|PubMed:9334180, ECO:0000269|PubMed:9694857}. Endosomal/prevacuolar sodium/hydrogen exchanger (Endosomal/prevacuolar Na(+)/H(+) exchanger) (Vacuolar protein sorting-associated protein 44) "NHX1, NHA2, VPL27, VPS44; bifunctional K:H/Na:H antiporter NHX1" Na+/H+ eXchanger "SLC9A9 exchanges Na+ for H+ across the late endosome membrane;SLC9A6,7 exchange Na+ for H+ across the early endosome membrane;Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at trans-golgi membrane);Na+/H+ exchanger transport (at trans-golgi membrane)" "SLC9A9 exchanges Na+ for H+ across the late endosome membrane;SLC9A6,7 exchange Na+ for H+ across the early endosome membrane;Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at trans-golgi membrane);Na+/H+ exchanger transport (at trans-golgi membrane)" 5 out of 5 NA "Na+ (out) + H+ (in) <=> Na+ (in) + H+ (out); K+ (out) + H+ (in) <=> K+ (in) + H+ (out)" YES "Na+/H+ exchanger transport; K+/H+ exchanger transport" Sodium/Proton exchangers NA cytoplasm "vacuole;cytoplasm;endoplasmic reticulum;Golgi" cytoplasm -406 YDR516C "Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" 2.7.1.2 Non-essential protein of unknown function Putative glucokinase involved in phosphorylation of aldohexoses and glucose uptake (By similarity). Involved in sporulation. Required for the full activation of the early meiotic inducer IME1. {ECO:0000250, ECO:0000269|PubMed:12586695}. 2.7.1.2 Putative glucokinase-2 (EC 2.7.1.2) (Early meiotic induction protein 2) (Glucose kinase 2) (GLK-2) "EMI2; putative glucokinase" 2.7.1.1 putative glucokinase-2 "glucokinase [nucleoplasm] => glucokinase [cytosol];glucokinase [nucleoplasm] => glucokinase [cytosol];Exocytosis of secretory granule lumen proteins;Exocytosis of secretory granule lumen proteins;Exocytosis of ficolin-rich granule lumen proteins;Exocytosis of ficolin-rich granule lumen proteins;HK1,2,3,GCK phosphorylate Glc to form G6P;HK1,2,3,GCK phosphorylate Glc to form G6P;HK1,2,3,GCK phosphorylate Glc to form G6P" "D-glucose + ATP => D-glucose 6-phosphate + ADP + H(+);D-glucose 6-phosphate + ADP + H(+) => D-glucose + ATP" "ATP + H2O = ADP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate;ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate;ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate;ATP + D-fructose = ADP + D-fructose 6-phosphate;ATP + D-mannose = ADP + D-mannose 6-phosphate;ITP + D-glucose = IDP + D-glucose 6-phosphate;2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate;ATP + beta-D-glucose = ADP + beta-D-glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate" "D-glucose + ATP => D-glucose 6-phosphate + ADP + H(+);D-glucose 6-phosphate + ADP + H(+) => D-glucose + ATP" "ATP + H2O = ADP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate;ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate;ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate;ATP + D-fructose = ADP + D-fructose 6-phosphate;ATP + D-mannose = ADP + D-mannose 6-phosphate;ITP + D-glucose = IDP + D-glucose 6-phosphate;2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate;ATP + beta-D-glucose = ADP + beta-D-glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate" D-glucopyranose + ATP => D-glucopyranose 6-phosphate + ADP + H+ "ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate;ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ATP + D-Mannose <=> ADP + D-Mannose 6-phosphate;ATP + beta-D-Glucose <=> ADP + beta-D-Glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate;ATP + D-Glucosamine <=> ADP + D-Glucosamine 6-phosphate;ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate" "glucokinase [nucleoplasm] => glucokinase [cytosol];glucokinase [nucleoplasm] => glucokinase [cytosol];HK1,2,3,GCK phosphorylate Glc to form G6P" 4 out of 5 ATP + D-glucose = ADP + D-glucose 6-phosphate. ATP + D-glucose <=> ADP + D-glucose 6-phosphate YES Glycolysis / Gluconeogenesis pathway from kegg "E388;H1171" "Glycolysis / Gluconeogenesis;Fructose and mannose metabolism;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism" chitin biosynthesis // sucrose degradation III (sucrose invertase) // glycolysis III (from glucose) // trehalose degradation II (trehalase) // glucose-6-phosphate biosynthesis "Regulation of Glucokinase by Glucokinase Regulatory Protein;Neutrophil degranulation;Glycolysis" "Glycolysis / Gluconeogenesis;path:map00010;Galactose metabolism;path:map00052;Starch and sucrose metabolism;path:map00500;Amino sugar and nucleotide sugar metabolism;path:map00520;Streptomycin biosynthesis;path:map00521;Neomycin, kanamycin and gentamicin biosynthesis;path:map00524;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" cytoplasm cytoplasm cytoplasm -410 YDR533C "Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress" 4.2.1.130 Methylglyoxalase that converts methylglyoxal to D-lactate Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals (PubMed:24302734). Involved in protection against reactive oxygen species (ROS) (PubMed:17395014). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893). {ECO:0000269|PubMed:17395014, ECO:0000269|PubMed:24302734, ECO:0000269|PubMed:24706893}. 4.2.1.130 Glutathione-independent glyoxalase HSP31 (EC 4.2.1.130) (Glyoxalase 3 homolog 1) (Heat shock protein 31) "HSP31; glutathione-independent methylglyoxalase" Heat-Shock Protein "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O 5 out of 5 (R)-lactate = methylglyoxal + H(2)O. {ECO:0000269|PubMed:24302734, ECO:0000269|PubMed:24758716}. (R)-lactate <=> methylglyoxal + H2O YES Methylglyoxal Metabolism pathway from e.coli model E513 "Pyruvate metabolism;path:map00620;Microbial metabolism in diverse environments;path:map01120" cytoplasm cytoplasm cytoplasm -412 YGL006W "Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a" 3.6.3.8 Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium. 3.6.3.8 Calcium-transporting ATPase 2 (EC 3.6.3.8) (Vacuolar Ca(2+)-ATPase) "PMC1; calcium-transporting ATPase PMC1" 3.6.3.8 Plasma Membrane Calcium "ATP2B1-4 transport cytosolic Ca2+ to extracellular region;ATP2B1-4 transport cytosolic Ca2+ to extracellular region;ATP2B1-4 transport cytosolic Ca2+ to extracellular region;ATP2B1-4 transport cytosolic Ca2+ to extracellular region;ATP2B4 binds to NOS1, inhibiting it" "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate;ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2];ATP + H2O + 2 Ca2+[cytoplasm side] = ADP + phosphate + 2 Ca2+[lumen side]" "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate;ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2];ATP + H2O + 2 Ca2+[cytoplasm side] = ADP + phosphate + 2 Ca2+[lumen side]" Ca2+[out] + ATP + H2O = Ca2+[in] + ADP + phosphate + H+ 4 out of 5 ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). Ca2+[out] + ATP + H2O <=> Ca2+[in] + ADP + phosphate + H+ YES Ca2+ transport pathway from reactome E586 "Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases" NA vacuolar membrane "vacuole;vacuolar membrane;cell envelope" vacuolar membrane -414 YGL017W "Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway" 2.3.2.8 Arginyl-tRNA-protein transferase Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). {ECO:0000250}. 2.3.2.8 Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) "ATE1; arginyltransferase" 2.3.2.8 arginyl-tRNA-protein transferase "L-arginyl-tRNA(Arg) + a [protein] N-terminus => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg);H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => L-arginyl-tRNA(Arg) + a [protein] N-terminus" "L-Arginyl-tRNA(Arg) + Protein <=> tRNA(Arg) + L-Arginyl-protein;L-arginyl-[tRNAarg] + protein = tRNAarg + N-terminal arginyl-[protein];L-arginyl-[tRNAarg] + N-terminal L-glutamyl-[protein] = tRNAarg + N-terminal L-arginiyl-L-glutamyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal L-aspartyl-[protein] = tRNAarg + N-terminal L-arginiyl-L-aspartyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal 3-sulfino-L-alanyl-[protein] = tRNAarg + N-terminal L-arginiyl-3-sulfino-L-alanyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal 3-sulfo-L-alanyl-[protein] = tRNAarg + N-terminal L-arginiyl-3-sulfo-L-alanyl-[protein] + H+;L-arginyl-tRNAArg + calreticulin = tRNAArg + L-arginyl-[calreticulin];L-arginyl-tRNAArg + protein disulfide isomerase = tRNAArg + L-arginyl-[protein disulfide isomerase];L-arginyl-tRNAArg + BiP/GRP78 protein = tRNAArg + L-arginyl-[BiP/GRP78 protein];L-arginyl-tRNAArg + acceptor protein = tRNAArg + L-arginyl-[acceptor protein];L-Arg-tRNA + apolipoprotein A-I = tRNAArg + L-Arg-[apolipoprotein A-I];L-Arg-tRNAArg + alpha-1-antitrypsin = tRNAArg + L-Arg-[alpha-1-antitrypsin];L-Arg-tRNAArg + apolipoprotein E = tRNAArg + L-Arg-[apolipoprotein E];L-Arg-tRNAArg + calreticulin = tRNAArg + L-Arg-[calreticulin];L-Arg-tRNAArg + protein-disulfide isomerase = tRNAArg + L-Arg-[protein-disulfide isomerase];L-Arg-tRNAArg + hemopexin = tRNAArg + L-Arg-[hemopexin];L-Arg-tRNAArg + contrapsin-like protease inhibitor-3 = tRNAArg + L-Arg-[contrapsin-like protease inhibitor-3];L-Arg-tRNAArg + glucose-related protein 78 = tRNAArg + L-Arg-[glucose-related protein 78];L-arginyl-tRNAArg + protein = tRNAArg + L-arginyl-[protein]" "L-arginyl-tRNA(Arg) + a [protein] N-terminus => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg);H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => L-arginyl-tRNA(Arg) + a [protein] N-terminus" "L-Arginyl-tRNA(Arg) + Protein <=> tRNA(Arg) + L-Arginyl-protein;L-arginyl-[tRNAarg] + protein = tRNAarg + N-terminal arginyl-[protein];L-arginyl-[tRNAarg] + N-terminal L-glutamyl-[protein] = tRNAarg + N-terminal L-arginiyl-L-glutamyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal L-aspartyl-[protein] = tRNAarg + N-terminal L-arginiyl-L-aspartyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal 3-sulfino-L-alanyl-[protein] = tRNAarg + N-terminal L-arginiyl-3-sulfino-L-alanyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal 3-sulfo-L-alanyl-[protein] = tRNAarg + N-terminal L-arginiyl-3-sulfo-L-alanyl-[protein] + H+;L-arginyl-tRNAArg + calreticulin = tRNAArg + L-arginyl-[calreticulin];L-arginyl-tRNAArg + protein disulfide isomerase = tRNAArg + L-arginyl-[protein disulfide isomerase];L-arginyl-tRNAArg + BiP/GRP78 protein = tRNAArg + L-arginyl-[BiP/GRP78 protein];L-arginyl-tRNAArg + acceptor protein = tRNAArg + L-arginyl-[acceptor protein];L-Arg-tRNA + apolipoprotein A-I = tRNAArg + L-Arg-[apolipoprotein A-I];L-Arg-tRNAArg + alpha-1-antitrypsin = tRNAArg + L-Arg-[alpha-1-antitrypsin];L-Arg-tRNAArg + apolipoprotein E = tRNAArg + L-Arg-[apolipoprotein E];L-Arg-tRNAArg + calreticulin = tRNAArg + L-Arg-[calreticulin];L-Arg-tRNAArg + protein-disulfide isomerase = tRNAArg + L-Arg-[protein-disulfide isomerase];L-Arg-tRNAArg + hemopexin = tRNAArg + L-Arg-[hemopexin];L-Arg-tRNAArg + contrapsin-like protease inhibitor-3 = tRNAArg + L-Arg-[contrapsin-like protease inhibitor-3];L-Arg-tRNAArg + glucose-related protein 78 = tRNAArg + L-Arg-[glucose-related protein 78];L-arginyl-tRNAArg + protein = tRNAArg + L-arginyl-[protein]" a protein + an L-arginyl-[tRNAarg] => a tRNAarg + an N-terminal arginyl-[protein] L-Arginyl-tRNA(Arg) + Protein <=> tRNA(Arg) + L-Arginyl-protein 3 out of 5 L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein]. L-Arginyl-tRNA(Arg) + Protein <=> tRNA(Arg) + L-Arginyl-protein YES other No pathway from database H1249 NA cytoplasm cytoplasm cytoplasm -415 YGL018C "Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix" Specialized J-protein that functions in Fe-S cluster biogenesis Co-chaperone required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Stimulates the ATPase activity of its specialized Hsp70 chaperone partner SSQ1. Binds to the substrate protein ISU1 and targets it to SSQ1. May function together with SSQ1 in the dislocation of the Fe/S cluster from ISU1 and its insertion into apoproteins. {ECO:0000269|PubMed:11171977, ECO:0000269|PubMed:11273703, ECO:0000269|PubMed:11278728, ECO:0000269|PubMed:12756240, ECO:0000269|PubMed:12970193, ECO:0000269|PubMed:15123690, ECO:0000269|PubMed:16431909, ECO:0000269|PubMed:16551614, ECO:0000269|PubMed:9813017}. J-type co-chaperone JAC1, mitochondrial (J-type accessory chaperone 1) "JAC1; J-type chaperone JAC1" co-chaperone for [Fe-S] cluster biosynthesis "TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix;TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix;Precursor proteins enter TIM23 PAM complex;Precursor proteins enter TIM23 PAM complex;MPP hydrolyzes presequence of matrix precursors;Formation of 4Fe-4S cluster on ISCA1:ISCA2" a [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex + an [Fe-S cluster biosynthesis co-chaperone] => a [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + L-cysteine desulfurase 5 out of 5 NA a [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex + an [Fe-S cluster biosynthesis co-chaperone] => a [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + L-cysteine desulfurase YES iron-sulfur cluster biosynthesis pathway from biocyc iron-sulfur cluster biosynthesis Mitochondrial iron-sulfur cluster biogenesis NA mitochondrion mitochondrion mitochondrion -418 YGL022W "Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis" 2.4.99.18 Subunit of the oligosaccharyltransferase complex of the ER lumen Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000269|PubMed:12359722}. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 (Oligosaccharyl transferase subunit STT3) (EC 2.4.99.18) "STT3; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3" 2.4.99.18 oligosaccharyl transferase complex STT3 subunit "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate "Dolichyl diphosphooligosaccharide + Protein asparagine <=> Dolichyl diphosphate + Glycoprotein with the oligosaccharide chain attached by N-glycosyl linkage to protein L-asparagine;Protein asparagine + G00008 <=> Dolichyl diphosphate + G00009" 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. "Dolichyl diphosphooligosaccharide + Protein asparagine <=> Dolichyl diphosphate + Glycoprotein with the oligosaccharide chain attached by N-glycosyl linkage to protein L-asparagine;Protein asparagine + G00008 <=> Dolichyl diphosphate + G00009" YES N-Glycan biosynthesis pathway from kegg "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -419 YGL027C "Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress" 3.2.1.106 Processing alpha glucosidase I Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically (PubMed:9363442). Seems to play a role in beta-1,6-glucan synthesis (PubMed:8576053). {ECO:0000269|PubMed:8576053, ECO:0000269|PubMed:9363442}. 3.2.1.106 Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) (Glucosidase I) "CWH41, DER7, GLS1; Cwh41p" 3.2.1.106 "mannosyl-oligosaccharide 1,2-α-glucosidase" Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase "Glc3Man9GlcNAc2 + H2O = D-glucose + Glc2Man9GlcNAc2;4-methylumbelliferyl-alpha-D-glucoside + H2O = 4-methylumbelliferone + D-glucose;H2O + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;Glc3Man9GlcNAc + H2O = D-glucose + Glc2Man9GlcNAc" "Glc3Man9GlcNAc2 + H2O = D-glucose + Glc2Man9GlcNAc2;4-methylumbelliferyl-alpha-D-glucoside + H2O = 4-methylumbelliferone + D-glucose;H2O + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;Glc3Man9GlcNAc + H2O = D-glucose + Glc2Man9GlcNAc" a [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H2O => a [protein]-L-asparagine-[(glucosyl)2(mannosyl)9(N-acetylglucosaminyl)2] + D-glucopyranose H2O + G00009 <=> D-Glucose + G00171 5 out of 5 Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). {ECO:0000269|PubMed:23536181}. H2O + G00009 <=> D-Glucose + G00171 YES N-Glycan biosynthesis pathway from kegg H393 "PATHWAY: Glycan metabolism; N-glycan degradation. {ECO:0000305}." "N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (yeast) processing in the ER N-glycan trimming in the ER and Calnexin/Calreticulin cycle "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "vacuole;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -420 YGL038C "Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins" 2.4.1.232 Mannosyltransferase of the cis-Golgi apparatus Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates. Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. Has also the potential to transfer a second alpha-1,6-mannose to the Man(8)GlNAc(2) core oligosaccharide. {ECO:0000269|PubMed:1523886, ECO:0000269|PubMed:1628616, ECO:0000269|PubMed:17042779, ECO:0000269|PubMed:21979948, ECO:0000269|PubMed:7649302, ECO:0000269|PubMed:8253757}. 2.4.1.232 Initiation-specific alpha-1,6-mannosyltransferase (EC 2.4.1.232) (Outer chain elongation protein 1) "OCH1, LDB12, NGD29; Och1p" 2.4.1.232 "initiation-specific 1,6-α-mannosyltransferase" "GDP-D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GDP-D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GDP-alpha-D-mannose + lipid-linked D-mannose-oligosaccharide = lipid-linked alpha(1->6)-D-mannosyl-D-mannose-oligosaccharide + GDP;GDP-mannose + Man8GlcNAc = GDP + Man9GlcNAc" "GDP-D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GDP-D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GDP-alpha-D-mannose + lipid-linked D-mannose-oligosaccharide = lipid-linked alpha(1->6)-D-mannosyl-D-mannose-oligosaccharide + GDP;GDP-mannose + Man8GlcNAc = GDP + Man9GlcNAc" "GDP-alpha-D-mannose + a [protein]-L-asparagine-[(mannosyl)8(N-acetylglucosaminyl)2] => a [protein]-L-asparagine-[(mannosyl)9(N-acetylglucosaminyl)2] + GDP + H+;GDP-alpha-D-mannose + a [protein]-L-asparagine-[(mannosyl)9(N-acetylglucosaminyl)2] => a [protein]-L-asparagine-[(mannosyl)10(N-acetylglucosaminyl)2] + GDP + H+" GDP-D-mannose + G10694 <=> GDP + G01813 5 out of 5 Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage. {ECO:0000269|PubMed:1628616, ECO:0000269|PubMed:17042779}. GDP-D-mannose + G10694 <=> GDP + G01813 YES Various types of N-glycan biosynthesis pathway from kegg "Various types of N-glycan biosynthesis;Metabolic pathways" "Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" "endoplasmic reticulum membrane;Golgi membrane" "Golgi;Golgi membrane;endoplasmic reticulum;endoplasmic reticulum membrane" "Golgi membrane;endoplasmic reticulum membrane" -421 YGL047W "Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress; both human homologs ALG13 and ALG14 are required to complement yeast alg13 mutant" 2.4.1.141 Catalytic component of UDP-GlcNAc transferase Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. {ECO:0000269|PubMed:15615718, ECO:0000269|PubMed:16100110}. 2.4.1.141 UDP-N-acetylglucosamine transferase subunit ALG13 (EC 2.4.1.141) (Asparagine-linked glycosylation protein 13) "ALG13; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13" 2.4.1.141 UDP-N-acetylglucosamine transferase Alg13p subunit "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => N,N'-diacetylchitobiosyl diphosphodolichol + H(+) + UDP;N,N'-diacetylchitobiosyl diphosphodolichol + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol;N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-glucosaminyl-(1rarr4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + H+ + UDP;N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-glucuronic acid = D-glucuronyl-1,4-N-acetyl-D-glucosaminyl-diphosphodolichol + UDP" "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => N,N'-diacetylchitobiosyl diphosphodolichol + H(+) + UDP;N,N'-diacetylchitobiosyl diphosphodolichol + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol;N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-glucosaminyl-(1rarr4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + H+ + UDP;N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-glucuronic acid = D-glucuronyl-1,4-N-acetyl-D-glucosaminyl-diphosphodolichol + UDP" N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP + H+ UDP-N-acetyl-D-glucosamine + N-Acetyl-D-glucosaminyldiphosphodolichol <=> UDP + N,N'-Chitobiosyldiphosphodolichol 5 out of 5 UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol. UDP-N-acetyl-D-glucosamine + N-Acetyl-D-glucosaminyldiphosphodolichol <=> UDP + N,N'-Chitobiosyldiphosphodolichol YES N-Glycan biosynthesis pathway from kegg "H290;H1136" lipid-linked oligosaccharide biosynthesis "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum "nucleus;cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum -426 YGL065C "Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; human ALG2 complements the temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of the alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement" "2.4.1.132;2.4.1.257" Mannosyltransferase in the N-linked glycosylation pathway Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. {ECO:0000269|PubMed:16878994}. "2.4.1.132; 2.4.1.257" Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase) "ALG2; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase" "2.4.1.132;2.4.1.257" ALG2 mannosyltransferase "Addition of a second mannose to the N-glycan precursor by ALG2;Addition of a third mannose to the N-glycan precursor by Alg2" "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+);alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose;alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+);alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose" "GDP-mannose + beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol <=> GDP + alpha-D-Mannosyl-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol;GDP-D-mannose + beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> GDP + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;GDP-alpha-D-mannose + beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr3)-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+;GDPmannose + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol = GDP + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-3)Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol;GDPmannose + tetrasaccharide-diphosphoryl-lipid = GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid;GDP-D-mannose + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> GDP + alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;alpha-D-Man-(1rarr3)-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + H+ + GDP;GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol" "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+);alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose;alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+);alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose" "GDP-mannose + beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol <=> GDP + alpha-D-Mannosyl-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol;GDP-D-mannose + beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> GDP + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;GDP-alpha-D-mannose + beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr3)-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+;GDPmannose + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol = GDP + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-3)Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol;GDPmannose + tetrasaccharide-diphosphoryl-lipid = GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid;GDP-D-mannose + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> GDP + alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;alpha-D-Man-(1rarr3)-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + H+ + GDP;GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol" "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+;beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+" "GDP-D-mannose + G00003 <=> GDP + G00004;GDP-D-mannose + G00004 <=> GDP + G00005" 5 out of 5 "GDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994}.; GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994}." "GDP-D-mannose + G00003 <=> GDP + G00004;GDP-D-mannose + G00004 <=> GDP + G00005" YES N-Glycan biosynthesis pathway from kegg "H247;H1290;NA" lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100;NA" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -427 YGL070C "RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription" RNA polymerase II subunit B12.6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation. Involved in DNA repair of damage in the transcribed strand. Mediates a transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER). {ECO:0000269|PubMed:12411509}. DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (B12.6) (DNA-directed RNA polymerase II 14.2 kDa polypeptide) (DNA-directed RNA polymerase II subunit 9) "RPB9, SSU73; DNA-directed RNA polymerase II core subunit RPB9" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus -431 YGL104C "Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog, YBR241C, that arose from the whole genome duplication" NA Mitochondrial protein May be involved in vacuolar protein sorting. {ECO:0000269|PubMed:12134085}. NA Vacuolar protein sorting-associated protein 73 "VPS73; putative sugar transporter" NA Vacuolar Protein Sorting "SLC2A5 transports fructose from extracellular region to cytosol;SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT7 and GLUT11 transport glucose and fructose;GLUT7 and GLUT11 transport glucose and fructose;SLC2A9 transports Fru, Glc, urate;GLUT1 tetramer binds 4xATP;GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP;GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol;SLC2A1 tetramer transports Glc from cytosol to Golgi lumen;Exocytosis of secretory granule membrane proteins;Exocytosis of secretory granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol;GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol;GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol;GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" NA NA NA NA NA NA "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT7 and GLUT11 transport glucose and fructose;GLUT7 and GLUT11 transport glucose and fructose;SLC2A9 transports Fru, Glc, urate;GLUT1 tetramer binds 4xATP;GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP;GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol;SLC2A1 tetramer transports Glc from cytosol to Golgi lumen;Exocytosis of secretory granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol;GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol;GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol;GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" 3 out of 5 NA " Fru <=> Fru; Gal <=> Gal; Glc <=> Glc" YES hexose transport putative sugar transporter. Not sure NA NA NA NA NA "Cellular hexose transport;Vitamin C (ascorbate) metabolism;Regulation of insulin secretion;Lactose synthesis;Neutrophil degranulation;Intestinal hexose absorption" NA mitochondrial membrane "vacuole;mitochondrion;mitochondrial membrane" mitochondrial membrane -440 YGL156W "Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway" 3.2.1.24 Vacuolar alpha mannosidase Degrades free oligosaccharides in the vacuole. {ECO:0000269|PubMed:12723970}. 3.2.1.24 Alpha-mannosidase (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) "AMS1; alpha-mannosidase" 3.2.1.24 alpha mannosidase MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 "2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;Mannobiose + H2O <=> 2 D-Mannose;alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-D-GlcNAc + H2O <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-D-GlcNAc + D-Mannose;alpha-D-Man-(1->6)-beta-D-Man-(1->4)-D-GlcNAc + H2O <=> beta-D-Man-(1->4)-D-GlcNAc + D-Mannose;alpha-(1-3)-mannobiose + H2O = alpha-D-mannopyranose + D-mannopyranose;alpha-(1-2)-mannobiose + H2O = alpha-D-mannopyranose + D-mannopyranose;alpha-(1-6)-mannobiose = alpha-D-mannopyranose + D-mannopyranose;Manalpha(1-3)GlcNAc + H2O = alpha-D-mannopyranose + N-acetyl-D-glucosamine;Manalpha(1-6)GlcNAc + H2O = alpha-mannopyranose + N-acetyl-D-glucosamine;Man9GlcNAc2 + H2O = Man8GlcNAc2 + mannose;mannotriose + H2O = alpha-D-mannopyranose + mannobiose;mannotetraose + H2O = alpha-D-mannopyranose + mannotriose;Man5GlcNAc2 + H2O = Man4GlcNAc2 + alpha-D-mannopyranose;Man9GlcNAc2 + H2O = Man5-8GlcNAc2 + alpha-D-mannopyranose;Man7GlcNAc + 2 H2O = Man5GlcNAc + 2 alpha-D-mannopyranose;2 Man9GlcNAc + 3 H2O = Man8GlcNAc + Man7GlcNAc + 3 alpha-D-mannopyranose;3-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;Man9-5GlcNAc + 4 H2O = Man5-3GlcNAc + 4 alpha-D-mannopyranose;Manalpha(1-4)Manbeta(1-4)Man + H2O = alpha-D-mannopyranose + Manbeta(1-4)Man;mannosyl rhamnose + H2O = alpha-D-mannopyranose + rhamnose;Man5GlcNAc + 2 H2O = Man3GlcNAc + 2 alpha-D-mannopyranose;GDP-mannosylpyranose + H2O = alpha-D-mannopyranose + GDP;Man8GlcNAc + 3 H2O = Man5GlcNAc + 3 alpha-D-mannopyranose;Man3GlcNAc2 + H2O = Man2GlcNAc2 + alpha-D-mannopyranose;Man8GlcNAc2 + 3 H2O = Man5GlcNAc2 + 3 D-mannose;Man8GlcNAc2 + 3 H2O = Man5GlcNAc2 + 3 alpha-D-mannopyranose;alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O = 6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc;alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + H2O = alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc + alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)-beta-D-Man" "2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;Mannobiose + H2O <=> 2 D-Mannose;alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-D-GlcNAc + H2O <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-D-GlcNAc + D-Mannose;alpha-D-Man-(1->6)-beta-D-Man-(1->4)-D-GlcNAc + H2O <=> beta-D-Man-(1->4)-D-GlcNAc + D-Mannose;alpha-(1-3)-mannobiose + H2O = alpha-D-mannopyranose + D-mannopyranose;alpha-(1-2)-mannobiose + H2O = alpha-D-mannopyranose + D-mannopyranose;alpha-(1-6)-mannobiose = alpha-D-mannopyranose + D-mannopyranose;Manalpha(1-3)GlcNAc + H2O = alpha-D-mannopyranose + N-acetyl-D-glucosamine;Manalpha(1-6)GlcNAc + H2O = alpha-mannopyranose + N-acetyl-D-glucosamine;Man9GlcNAc2 + H2O = Man8GlcNAc2 + mannose;mannotriose + H2O = alpha-D-mannopyranose + mannobiose;mannotetraose + H2O = alpha-D-mannopyranose + mannotriose;Man5GlcNAc2 + H2O = Man4GlcNAc2 + alpha-D-mannopyranose;Man9GlcNAc2 + H2O = Man5-8GlcNAc2 + alpha-D-mannopyranose;Man7GlcNAc + 2 H2O = Man5GlcNAc + 2 alpha-D-mannopyranose;2 Man9GlcNAc + 3 H2O = Man8GlcNAc + Man7GlcNAc + 3 alpha-D-mannopyranose;3-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;Man9-5GlcNAc + 4 H2O = Man5-3GlcNAc + 4 alpha-D-mannopyranose;Manalpha(1-4)Manbeta(1-4)Man + H2O = alpha-D-mannopyranose + Manbeta(1-4)Man;mannosyl rhamnose + H2O = alpha-D-mannopyranose + rhamnose;Man5GlcNAc + 2 H2O = Man3GlcNAc + 2 alpha-D-mannopyranose;GDP-mannosylpyranose + H2O = alpha-D-mannopyranose + GDP;Man8GlcNAc + 3 H2O = Man5GlcNAc + 3 alpha-D-mannopyranose;Man3GlcNAc2 + H2O = Man2GlcNAc2 + alpha-D-mannopyranose;Man8GlcNAc2 + 3 H2O = Man5GlcNAc2 + 3 D-mannose;Man8GlcNAc2 + 3 H2O = Man5GlcNAc2 + 3 alpha-D-mannopyranose;alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O = 6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc;alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + H2O = alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc + alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)-beta-D-Man" "2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H2O => D-mannopyranose 6-phosphate + D-glycerate;an alpha-D-mannoside + H2O => alpha-D-mannopyranose + a non glycosylated sugar acceptor" MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 5 out of 5 Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. "2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H2O => D-mannopyranose 6-phosphate + D-glycerate;an alpha-D-mannoside + H2O => alpha-D-mannopyranose + a non glycosylated sugar acceptor" YES Other glycan degradation pathway from kegg H26 Other glycan degradation Lysosomal oligosaccharide catabolism "Other glycan degradation;path:map00511" vacuole vacuole vacuole -442 YGL167C "High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant" 3.6.3.8 High affinity Ca2+/Mn2+ P-type ATPase This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway. 3.6.3.8 Calcium-transporting ATPase 1 (EC 3.6.3.8) (Bypass SOD defects protein 1) (Golgi Ca(2+)-ATPase) "PMR1, BSD1, LDB1, SSC1; Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1" 3.6.3.8 Plasma Membrane ATPase Related "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen;ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen;ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen;ATP2A1-3 transport Ca2+ from cytosol to ER lumen;ATP2A1-3 transport Ca2+ from cytosol to ER lumen;ATP2A1-3 transport Ca2+ from cytosol to ER lumen;ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen;ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen" "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate;ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2];ATP + H2O + 2 Ca2+[cytoplasm side] = ADP + phosphate + 2 Ca2+[lumen side]" "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate;ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2];ATP + H2O + 2 Ca2+[cytoplasm side] = ADP + phosphate + 2 Ca2+[lumen side]" Ca2+[out] + ATP + H2O = Ca2+[in] + ADP + phosphate + H+ "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen;ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen" 5 out of 5 ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). Ca2+[out] + ATP + H2O <=> Ca2+[in] + ADP + phosphate + H+ YES "Ca2+ transport; Mg2+ transport" "required for Ca2+ and Mn2+ transport into Golgi; pathway from reactome" E586 "Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases" NA Golgi membrane "Golgi membrane;Golgi;cell envelope" Golgi membrane -443 YGL169W "Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length" 2.7.7.87 Protein involved in threonylcarbamoyl adenosine biosynthesis Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length. {ECO:0000269|PubMed:19287007, ECO:0000269|PubMed:19369944, ECO:0000269|PubMed:19884342, ECO:0000269|PubMed:21183954, ECO:0000269|PubMed:23258706, ECO:0000269|PubMed:23620299}. 2.7.7.87 Threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (Suppressor of upstream AUG protein 5) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein SUA5) (tRNA threonylcarbamoyladenosine biosynthesis protein SUA5) "SUA5; threonylcarbamoyladenylate synthase" 2.7.7.87 Suppressor of Upstream AUG NA "L-threonine + ATP + hydrogencarbonate => L-threonylcarbamoyladenylate + diphosphate + H2O;L-threonylcarbamoyladenylate + diphosphate + H2O => L-threonine + ATP + hydrogencarbonate" "L-threonine + ATP + HCO3- = L-threonylcarbamoyladenylate + diphosphate + H2O;L-threonylcarbamoyl-AMP + tRNA = t6A37-tRNA;L-threonine + ATP + CO2 = L-threonylcarbamoyl-AMP + diphosphate" "L-threonine + ATP + hydrogencarbonate => L-threonylcarbamoyladenylate + diphosphate + H2O;L-threonylcarbamoyladenylate + diphosphate + H2O => L-threonine + ATP + hydrogencarbonate" "L-threonine + ATP + HCO3- = L-threonylcarbamoyladenylate + diphosphate + H2O;L-threonylcarbamoyl-AMP + tRNA = t6A37-tRNA;L-threonine + ATP + CO2 = L-threonylcarbamoyl-AMP + diphosphate" NA L-Threonine + ATP + HCO3- + H+ <=> L-Threonylcarbamoyladenylate + Diphosphate + H2O NA 5 out of 5 L-threonine + ATP + HCO(3)(-) = L-threonylcarbamoyladenylate + diphosphate + H(2)O. {ECO:0000269|PubMed:23620299}. L-Threonine + ATP + HCO3- + H+ <=> L-Threonylcarbamoyladenylate + Diphosphate + H2O YES Other NA NA NA NA NA NA NA NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -450 YGL196W "D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate" 4.3.1.18 D-serine dehydratase (aka D-serine ammonia-lyase) Converts specifically D-serine to pyruvate and ammonia. May play a role in D-serine detoxification. {ECO:0000269|PubMed:17869212, ECO:0000269|PubMed:17937657}. 4.3.1.18 D-serine dehydratase (EC 4.3.1.18) (D-serine deaminase) (DSD) "DSD1; D-serine ammonia-lyase DSD1" 4.3.1.18 DSD1 "D-serine => NH4(+) + pyruvate;NH4(+) + pyruvate => D-serine" "D-Serine = pyruvate + NH3;3-chloro-D-alanine + H2O = pyruvate + chloride + NH3;alpha-Amino acid <=> 2-Oxo acid + Ammonia" "D-serine => NH4(+) + pyruvate;NH4(+) + pyruvate => D-serine" "D-Serine = pyruvate + NH3;3-chloro-D-alanine + H2O = pyruvate + chloride + NH3;alpha-Amino acid <=> 2-Oxo acid + Ammonia" D-Serine <=> Pyruvate + Ammonia 4 out of 5 D-serine = pyruvate + NH(3). {ECO:0000269|PubMed:17869212, ECO:0000269|PubMed:17937657}. D-Serine <=> Pyruvate + Ammonia YES Glycine, serine and threonine metabolism pathway from kegg E630 Glycine, serine and threonine metabolism "Glycine, serine and threonine metabolism;path:map00260" -456 YGL226C-A "Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins" 2.4.99.18 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5 (Oligosaccharyl transferase subunit OST5) (EC 2.4.99.18) (Oligosaccharyl transferase 9.5 kDa subunit) (Oligosaccharyl transferase subunit zeta) "OST5; dolichyl-diphosphooligosaccharide--protein glycotransferase subunit" "oligosaccharyl transferase complex ζ subunit" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate 4 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -460 YGL257C "Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans" 2.4.1.- Mannosyltransferase Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans. 2.4.1.- Alpha-1,3-mannosyltransferase MNT2 (EC 2.4.1.-) "MNT2; alpha-1,3-mannosyltransferase MNT2" "α-1,3-mannosyltransferase MMN2" GDP-alpha-D-mannose + an alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] => an alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] + GDP + H+ "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" 3 out of 5 NA "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" YES Other types of O-glycan biosynthesis pathway from kegg "H815;H837;H838;H839" "PATHWAY: Protein modification; protein glycosylation." Other types of O-glycan biosynthesis protein O-mannosylation I (yeast) NA Golgi membrane "Golgi membrane;vacuole;Golgi;cell envelope" Golgi membrane -462 YGR012W "Putative cysteine synthase; localized to the mitochondrial outer membrane" 2.5.1.47 Putative cysteine synthase Putative cysteine synthase that catalyzes the conversion of O-acetyl-L-serine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway. However, this CS-like protein is unlikely to function in cysteine biosynthesis. It seems that in S.cerevisiae cysteine biosynthesis occurs exclusively through the cystathionine pathway and not via direct incorporation of sulfur into OAS. {ECO:0000305|PubMed:9409150}. 2.5.1.47 Putative cysteine synthase (CS) (EC 2.5.1.47) (Cysteine synthase-like protein) (CSl) (O-acetylserine (thiol)-lyase) (OAS-TL) (O-acetylserine sulfhydrylase) "MCY1; putative cysteine synthase" 2.5.1.47 cysteine synthase "O-acetyl-L-serine + hydrogen sulfide => L-cysteine + acetate;L-cysteine + acetate => O-acetyl-L-serine + hydrogen sulfide" "O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate;O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate;O-acetyl-L-serine + thiosulfate = S-sulfo-L-cysteine + acetate;O-acetyl-Ser + selenide = selenocysteine + acetate;O-Acetyl-L-serine + Thiosulfate + Thioredoxin + H+ <=> L-Cysteine + Sulfite + Thioredoxin disulfide + Acetate;L-cysteine + dithiothreitol = S-(2,3-hydroxy-4-thiobutyl)-L-cysteine + H2S" "O-acetyl-L-serine + hydrogen sulfide => L-cysteine + acetate;L-cysteine + acetate => O-acetyl-L-serine + hydrogen sulfide" "O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate;O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate;O-acetyl-L-serine + thiosulfate = S-sulfo-L-cysteine + acetate;O-acetyl-Ser + selenide = selenocysteine + acetate;O-Acetyl-L-serine + Thiosulfate + Thioredoxin + H+ <=> L-Cysteine + Sulfite + Thioredoxin disulfide + Acetate;L-cysteine + dithiothreitol = S-(2,3-hydroxy-4-thiobutyl)-L-cysteine + H2S" "O-acetyl-L-serine + hydrogen selenide = L-selenocysteine + acetate + H+;O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate + H+;O-acetyl-L-serine + thiosulfate = S-sulfo-L-cysteine + acetate + H+" "O-Acetyl-L-serine + Hydrogen sulfide <=> L-Cysteine + Acetate;O-Acetyl-L-serine + Hydrogen selenide <=> L-Selenocysteine + Acetate;O-Acetyl-L-serine + Thiosulfate + Thioredoxin + H+ <=> L-Cysteine + Sulfite + Thioredoxin disulfide + Acetate" 3 out of 5 O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. {ECO:0000250|UniProtKB:P0ABK5}. O-acetyl-L-serine + hydrogen sulfide <=> L-cysteine + acetate YES Cysteine and methionine metabolism pathway from kegg E364 "Cysteine and methionine metabolism;Sulfur metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids" "Cysteine and methionine metabolism;path:map00270;Sulfur metabolism;path:map00920;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Biosynthesis of antibiotics;path:map01130" "mitochondrion;mitochondrial membrane" "mitochondrion;mitochondrial membrane" "mitochondrion;mitochondrial membrane" -466 YGR036C "Dolichyl pyrophosphate (Dol-P-P) phosphatase; has a luminally oriented active site in the ER; cleaves the anhydride linkage in Dol-P-P; required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation" 3.6.1.43 Dolichyl pyrophosphate (Dol-P-P) phosphatase Non-essential protein which is required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. {ECO:0000269|PubMed:10024662, ECO:0000269|PubMed:11504728}. 3.6.1.43 Dolichyldiphosphatase (EC 3.6.1.43) (Dolichyl pyrophosphate phosphatase) "CAX4, CWH8; Cax4p" 3.6.1.43 CAX4 DOLPP1 dephosphorylates DOLDP to DOLP "dolichyl diphosphate + H2O => dolichyl phosphate + H(+) + phosphate;dolichyl phosphate + H(+) + phosphate => dolichyl diphosphate + H2O" dolichyl diphosphate + H2O = dolichyl phosphate + phosphate "dolichyl diphosphate + H2O => dolichyl phosphate + H(+) + phosphate;dolichyl phosphate + H(+) + phosphate => dolichyl diphosphate + H2O" dolichyl diphosphate + H2O = dolichyl phosphate + phosphate a dolichyl diphosphate + H2O = a dolichyl phosphate + phosphate + H+ Dolichyl diphosphate + H2O <=> Dolichyl phosphate + Orthophosphate 4 out of 5 Dolichyl diphosphate + H(2)O = dolichyl phosphate + phosphate. Dolichyl diphosphate + H2O <=> Dolichyl phosphate + Orthophosphate YES N-Glycan biosynthesis pathway from kegg "H193;H1135" "PATHWAY: Protein modification; protein glycosylation." N-Glycan biosynthesis Synthesis of Dolichyl-phosphate "N-Glycan biosynthesis;path:map00510" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -468 YGR043C "Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication" 2.2.1.2 Transaldolase of unknown function Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. 2.2.1.2 Transaldolase NQM1 (EC 2.2.1.2) (Non-quiescent mutant protein 1) "NQM1; sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1" 2.2.1.2 transaldolase "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate;sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate" "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => beta-D-fructose 6-phosphate + D-erythrose 4-phosphate;beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate" "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate;dihydroxyacetone + D-glyceraldehyde 3-phosphate = D-fructose 6-phosphate" "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => beta-D-fructose 6-phosphate + D-erythrose 4-phosphate;beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate" "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate;dihydroxyacetone + D-glyceraldehyde 3-phosphate = D-fructose 6-phosphate" D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> beta-D-fructofuranose 6-phosphate + D-erythrose 4-phosphate Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + beta-D-Fructose 6-phosphate "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate;sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate" 4 out of 5 Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. {ECO:0000255|PROSITE-ProRule:PRU10019, ECO:0000269|PubMed:18831051}. Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + beta-D-Fructose 6-phosphate YES Pentose phosphate pathway pathway from kegg "E70;H745" "PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3." "Pentose phosphate pathway;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids" pentose phosphate pathway // pentose phosphate pathway (non-oxidative branch) "Insulin effects increased synthesis of Xylulose-5-Phosphate;Pentose phosphate pathway (hexose monophosphate shunt)" "Pentose phosphate pathway;path:map00030;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" "nucleus;cytoplasm" -469 YGR046W "Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition" 2.7.7.41 Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase) Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. {ECO:0000269|PubMed:16790493, ECO:0000269|PubMed:16943180, ECO:0000269|PubMed:19114592, ECO:0000269|PubMed:23623749}. 2.7.7.41 Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (Mitochondrial import protein MMP37) (Mitochondrial matrix protein of 37 kDa) (Mitochondrial translocator assembly and maintenance protein 41) "TAM41, MMP37; putative phosphatidate cytidylyltransferase" Translocator Assembly and Maintenance 41 "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate;a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)" "CTP + phosphatidate = diphosphate + CDP-diacylglycerol;dCTP + phosphatidate = diphosphate + dCDPdiacylglycerol;CTP + 2,3,4-saturated L-phosphatidate + H+ = diphosphate + CDP-2,3,4-saturated-diacylglycerol" "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate;a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)" "CTP + phosphatidate = diphosphate + CDP-diacylglycerol;dCTP + phosphatidate = diphosphate + dCDPdiacylglycerol;CTP + 2,3,4-saturated L-phosphatidate + H+ = diphosphate + CDP-2,3,4-saturated-diacylglycerol" 5 out of 5 CTP + phosphatidate = diphosphate + CDP-diacylglycerol. {ECO:0000269|PubMed:23623749}. CTP + phosphatidate = diphosphate + CDP-diacylglycerol YES Glycerophospholipid metabolism "pathway from kegg; reaction from uniprot" "E679;H137;H788" "PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. {ECO:0000269|PubMed:19114592, ECO:0000269|PubMed:20485265}." "Glycerophospholipid metabolism;path:map00564;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Phosphatidylinositol signaling system;path:map04070" mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -471 YGR062C "Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p" NA Protein required for membrane insertion of C-terminus of Cox2p Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space. {ECO:0000269|PubMed:11950926}. NA Mitochondrial inner membrane protein COX18 (Cytochrome c oxidase assembly protein 18) "COX18, OXA2; membrane insertase COX18" NA Cytochrome c OXidase NA NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 4 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA NA aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -478 YGR144W "Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents" Thiazole synthase Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance. {ECO:0000255|HAMAP-Rule:MF_03158, ECO:0000269|PubMed:15544818, ECO:0000269|PubMed:16171982, ECO:0000269|PubMed:16734458, ECO:0000269|PubMed:17309261, ECO:0000269|PubMed:18652458, ECO:0000269|PubMed:22031445, ECO:0000269|PubMed:9367751}. Thiamine thiazole synthase (Thiazole biosynthetic enzyme) "THI4, ESP35, MOL1; thiamine thiazole synthase" NAD+ + Glycine + Sulfur donor <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + Nicotinamide + 3 H2O 5 out of 5 NA NAD+ + Glycine + Sulfur donor <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + Nicotinamide + 3 H2O YES Thiamine metabolism pathway from kegg thiamine biosynthesis "Thiamine metabolism;Metabolic pathways" NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -480 YGR154C "Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization" "1.8.5.1;2.5.1.18" Omega-class glutathione transferase Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). {ECO:0000269|PubMed:16709151}. "2.5.1.18; 1.8.5.1" Glutathione S-transferase omega-like 1 (EC 2.5.1.18) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) "GTO1; omega-class glutathione transferase" NA Glutathione Transferase Omega-like NA "L-dehydroascorbate + 2 glutathione => L-ascorbate + glutathione disulfide;L-ascorbate + glutathione disulfide => L-dehydroascorbate + 2 glutathione;glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate;5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione;L-dehydroascorbate + 2 glutathione => L-ascorbate + glutathione disulfide;L-ascorbate + glutathione disulfide => L-dehydroascorbate + 2 glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin;2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate" "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+;glutathione + 4-hydroxy-2-nonenal = 4-hydroxy-2-nonenal-glutathione conjugate;glutathione + RX = a glutathione-toxin conjugate + HX" NA NA 4 out of 5 "RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:16709151}.; 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate. {ECO:0000269|PubMed:16709151}." "RX + glutathione = HX + R-S-glutathione;2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate" YES Glutathione metabolism "pathway from kegg; reaction from uniprot" "H675;H1101;NA" NA NA NA NA NA "Glutathione metabolism;path:map00480;Metabolism of xenobiotics by cytochrome P450;path:map00980;Drug metabolism - cytochrome P450;path:map00982;NA" peroxisome peroxisome peroxisome -485 YGR199W "Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases" 2.4.1.109 Protein O-mannosyltransferase Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. {ECO:0000250|UniProtKB:P33775, ECO:0000303|PubMed:18182384, ECO:0000303|PubMed:9184828}. 2.4.1.109 Dolichyl-phosphate-mannose--protein mannosyltransferase 6 (EC 2.4.1.109) "PMT6; dolichyl-phosphate-mannose-protein mannosyltransferase PMT6" 2.4.1.109 dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase "[protein]-L-serine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => [protein]-L-serine + dolichyl beta-D-mannosyl phosphate;[protein]-L-threonine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+) => [protein]-L-threonine + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + alpha-D-Man-1-Ser/Thr;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein];dolichyl beta-D-mannosyl phosphate + [protein]-(L-serine/L-threonine) = dolichyl phosphate + [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+;dolichyl phosphate D-mannose + protein AN5660 = dolichyl phosphate + O-D-mannosylprotein;dolichyl phosphate D-mannose + alpha-dystroglycan = dolichyl phosphate + O-D-mannosyl-[alpha-dystroglycan];dolichyl phosphate D-mannose + protein Aga2 = dolichyl phosphate + O-D-mannosylprotein Aga2;dolichyl phosphate D-mannose + protein Bar1 = dolichyl phosphate + O-D-mannosylprotein Bar1;dolichyl phosphate D-mannose + protein chitinase 1 = dolichyl phosphate + O-D-mannosylprotein chitinase 1;dolichyl phosphate D-mannose + protein Ggp1/Gas1 = dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1;dolichyl phosphate D-mannose + protein Kex2 = dolichyl phosphate + O-D-mannosylprotein Kex2;dolichyl phosphate D-mannose + protein Kre9 = dolichyl phosphate + O-D-mannosylprotein Kre9;dolichyl phosphate D-mannose + protein Pir2/hsp150 = dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150;dolichyl phosphate D-mannose + ribonuclease 2 = dolichyl phosphate + ribonuclease 2-D-mannose;dolichyl phosphate D-mannose + glucoamylase I = dolichyl phosphate + O-D-mannosyl glucoamylase I;dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein" "[protein]-L-serine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => [protein]-L-serine + dolichyl beta-D-mannosyl phosphate;[protein]-L-threonine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+) => [protein]-L-threonine + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + alpha-D-Man-1-Ser/Thr;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein];dolichyl beta-D-mannosyl phosphate + [protein]-(L-serine/L-threonine) = dolichyl phosphate + [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+;dolichyl phosphate D-mannose + protein AN5660 = dolichyl phosphate + O-D-mannosylprotein;dolichyl phosphate D-mannose + alpha-dystroglycan = dolichyl phosphate + O-D-mannosyl-[alpha-dystroglycan];dolichyl phosphate D-mannose + protein Aga2 = dolichyl phosphate + O-D-mannosylprotein Aga2;dolichyl phosphate D-mannose + protein Bar1 = dolichyl phosphate + O-D-mannosylprotein Bar1;dolichyl phosphate D-mannose + protein chitinase 1 = dolichyl phosphate + O-D-mannosylprotein chitinase 1;dolichyl phosphate D-mannose + protein Ggp1/Gas1 = dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1;dolichyl phosphate D-mannose + protein Kex2 = dolichyl phosphate + O-D-mannosylprotein Kex2;dolichyl phosphate D-mannose + protein Kre9 = dolichyl phosphate + O-D-mannosylprotein Kre9;dolichyl phosphate D-mannose + protein Pir2/hsp150 = dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150;dolichyl phosphate D-mannose + ribonuclease 2 = dolichyl phosphate + ribonuclease 2-D-mannose;dolichyl phosphate D-mannose + glucoamylase I = dolichyl phosphate + O-D-mannosyl glucoamylase I;dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein" a dolichyl beta-D-mannosyl phosphate + a [protein]-(L-serine/L-threonine) => a dolichyl phosphate + a [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+ "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + G13027;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein]" 4 out of 5 Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein. {ECO:0000250|UniProtKB:P33775, ECO:0000303|PubMed:18182384, ECO:0000303|PubMed:9184828}. "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + G13027;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein]" YES Mannose type O-glycan biosynthesis "pathway from kegg; ; reaction from kegg" H1179 "PATHWAY: Protein modification; protein glycosylation. {ECO:0000305}." "Other types of O-glycan biosynthesis;Mannose type O-glycan biosynthesis;Metabolic pathways" protein O-mannosylation I (yeast) "Other types of O-glycan biosynthesis;path:map00514;Mannose type O-glycan biosynthesis;path:map00515;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -487 YGR216C "Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs" 2.4.1.198 Membrane protein involved in the synthesis of GlcNAc-PI Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. {ECO:0000269|PubMed:8910381}. 2.4.1.198 Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1 (GPI-GlcNAc transferase complex subunit GPI1) (GPI-GnT subunit GPI1) (EC 2.4.1.198) "GPI1; phosphatidylinositol N-acetylglucosaminyltransferase" GlycosylPhosphatidylInositol anchoring biosynthesis "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" an L-1-phosphatidyl-inositol + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H+ UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 3 out of 5 UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol. UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H479;H1129" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000305|PubMed:8910381}." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;path:map00563;Metabolic pathways;path:map01100" endoplasmic reticulum -488 YGR227W "Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase; located in the ER; functions in pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation; has a role in regulation of ITR1 and INO1; human homolog ALG10B can complement yeast die2 null mutant" 2.4.1.256 Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. {ECO:0000269|PubMed:9597543}. 2.4.1.256 Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10) (Asparagine-linked glycosylation protein 10) (Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10) "DIE2, ALG10; dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2-glucosyltransferase" 2.4.1.256 "dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol α-1,2-glucosyltransferase" Addition of a third glucose to the N-glycan skeleton by Alg10 "alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+ Dolichyl D-glucosyl phosphate + G10599 <=> Dolichyl phosphate + G00008 4 out of 5 Dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:9597543}. Dolichyl D-glucosyl phosphate + G10599 <=> Dolichyl phosphate + G00008 YES N-Glycan biosynthesis pathway from kegg lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" endoplasmic reticulum membrane -489 YGR234W "Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" 1.14.12.17 Nitric oxide oxidoreductase " Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.; FUNCTION: In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity." 1.14.12.17 Flavohemoprotein (EC 1.14.12.17) (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) "YHB1, YHB4; flavohemoglobin" 1.14.12.17 Yeast HemogloBin-like protein "NADPH + 2 nitric oxide + 2 O2 => H(+) + NADP(+) + 2 nitrate;H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2;NADH + 2 nitric oxide + 2 O2 => H(+) + NAD(+) + 2 nitrate;H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2" "2 nitric oxide + 2 O2 + NADPH = 2 nitrate + NADP+ + H+;2 nitric oxide + 2 O2 + NADH = 2 nitrate + NAD+ + H+;NADH + H+ + H2O2 = NAD+ + 2 H2O;NADH + Fe3+ = NAD+ + Fe2+;nitrite + NADH = NO + NAD+ + H2O;NO + O2 + e- = NO3-" "NADPH + 2 nitric oxide + 2 O2 => H(+) + NADP(+) + 2 nitrate;H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2;NADH + 2 nitric oxide + 2 O2 => H(+) + NAD(+) + 2 nitrate;H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2" "2 nitric oxide + 2 O2 + NADPH = 2 nitrate + NADP+ + H+;2 nitric oxide + 2 O2 + NADH = 2 nitrate + NAD+ + H+;NADH + H+ + H2O2 = NAD+ + 2 H2O;NADH + Fe3+ = NAD+ + Fe2+;nitrite + NADH = NO + NAD+ + H2O;NO + O2 + e- = NO3-" 2 nitric oxide + NAD(P)H + 2 oxygen => 2 nitrate + NAD(P)+ + H+ 5 out of 5 2 nitric oxide + 2 O(2) + NAD(P)H = 2 nitrate + NAD(P)(+) + H(+). {ECO:0000269|PubMed:10922365}. 2 nitric oxide + 2 O2 + NAD(P)H <=> 2 nitrate + NAD(P)+ + H+ YES Nitrogen Metabolism "[c] : nadph + (2) no + (2) o2 --> h + nadp + (2) no3; Nitrogen Metabolism: pathway from e.coli model" E519 NA cytoplasm "nucleus;cytoplasm;mitochondrion" cytoplasm -497 YHR001W-A "Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain" NA Subunit of the ubiqunol-cytochrome c oxidoreductase complex Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR10 is required for stable association of the iron-sulfur protein with the complex. NA Cytochrome b-c1 complex subunit 10 (Complex III subunit 10) (Complex III subunit XI) (Ubiquinol-cytochrome c reductase complex 8.5 kDa protein) "QCR10; ubiquinol--cytochrome-c reductase subunit 10" NA ubiquinol-cytochrome C oxidoreductase NA NA NA NA NA 2 an oxidized c-type cytochrome[out] + an ubiquinol[membrane] => 2 a reduced c-type cytochrome[out] + a ubiquinone[membrane] + 2 H+[out] NA NA 4 out of 5 NA 2 an oxidized c-type cytochrome[out] + an ubiquinol[membrane] => 2 a reduced c-type cytochrome[out] + a ubiquinone[membrane] + 2 H+[out] YES Oxidative phosphorylation pathway from kegg NA aerobic respiration, electron transport chain NA "Oxidative phosphorylation;Metabolic pathways" aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -499 YJL002C "Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins" 2.4.99.18 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (EC 2.4.99.18) (Oligosaccharyl transferase 64 kDa subunit) (Oligosaccharyl transferase subunit OST1) (Oligosaccharyl transferase subunit alpha) "OST1, NLT1; dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1" NA "oligosaccharyl transferase complex α subunit" NA "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA NA 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps NA "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -500 YJL003W "Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase" NA Mitochondrial inner membrane protein Required for the assembly of cytochrome c oxidase. {ECO:0000269|PubMed:12446688}. NA Cytochrome c oxidase assembly protein COX16, mitochondrial "COX16; Cox16p" NA Cytochrome c OXidase NA NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 3 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA NA aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -501 YJL011C "RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" RNA polymerase III subunit C17 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation. DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (RNA polymerase III subunit C17) "RPC17; DNA-directed RNA polymerase III subunit RPC17" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase NA nucleus "nucleus;cytoplasm" nucleus -506 YJL046W "Putative lipoate-protein ligase; required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss" "2.7.7.63;6.3.1.20" Putative lipoate-protein ligase Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. {ECO:0000250}. 6.3.1.20 Putative lipoate-protein ligase A (EC 6.3.1.20) (Altered inheritance rate of mitochondria protein 22) "AIM22, LIP3, RRG3; putative lipoate--protein ligase" 6.3.1.20 octanoyl-CoA-protein transferase LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs "(R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP => [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+);[lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+) => (R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP" "ATP + (R)-lipoate = lipoyl-AMP + diphosphate;ATP + (R)-Lipoate + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP + Diphosphate;Lipoyl-AMP + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP;[glycine cleavage system lipoyl-carrier protein]-L-lysine + ATP + (R)-lipoate = AMP + diphosphate + [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + H+;[lipoyl-carrier protein]-L-lysine + octanoate + ATP = [lipoyl-carrier protein] N6-octanoyl-L-lysine + AMP + diphosphate + H+;ATP + lipoate + apoprotein = AMP + diphosphate + protein N6-(lipoyl)lysine;lipoic acid + ATP + apoprotein = diphosphate + AMP + N6-(lipoyl)-lysine;lipoyl-AMP + [GLDH1 protein]-L-lysine = [GLDH1 protein]-N6-(lipoyl)lysine + AMP" "(R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP => [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+);[lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+) => (R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP" "ATP + (R)-lipoate = lipoyl-AMP + diphosphate;ATP + (R)-Lipoate + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP + Diphosphate;Lipoyl-AMP + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP;[glycine cleavage system lipoyl-carrier protein]-L-lysine + ATP + (R)-lipoate = AMP + diphosphate + [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + H+;[lipoyl-carrier protein]-L-lysine + octanoate + ATP = [lipoyl-carrier protein] N6-octanoyl-L-lysine + AMP + diphosphate + H+;ATP + lipoate + apoprotein = AMP + diphosphate + protein N6-(lipoyl)lysine;lipoic acid + ATP + apoprotein = diphosphate + AMP + N6-(lipoyl)-lysine;lipoyl-AMP + [GLDH1 protein]-L-lysine = [GLDH1 protein]-N6-(lipoyl)lysine + AMP" "octanoyl-CoA + [2-oxoglutarate dehydrogenase E2 lipoyl-carrier protein]-L-lysine => a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + coenzyme A + H+;octanoyl-CoA + [pyruvate dehydrogenase E2 lipoyl-carrier protein]-L-lysine => a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + coenzyme A + H+" "ATP + (R)-Lipoate <=> Diphosphate + Lipoyl-AMP;Lipoyl-AMP + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP;ATP + (R)-Lipoate + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP + Diphosphate" 4 out of 5 ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N(6)-(lipoyl)lysine + AMP + diphosphate. "ATP + (R)-Lipoate <=> Diphosphate + Lipoyl-AMP;Lipoyl-AMP + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP;ATP + (R)-Lipoate + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP + Diphosphate" YES Lipoic acid metabolism pathway from kegg "PATHWAY: Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.; PATHWAY: Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2." "Lipoic acid metabolism;Metabolic pathways" superpathway of lipoate biosynthesis and incorporation (PDH, KGDH, GCV) // lipoate biosynthesis and incorporation (pyruvate dehydrogenase and oxoglutarate dehydrogenase) Glyoxylate metabolism and glycine degradation "Lipoic acid metabolism;path:map00785;Metabolic pathways;path:map01100" mitochondrion -509 YJL062W "Integral plasma membrane protein; involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity" 2.-.-.- Integral plasma membrane protein Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. Although not essential, addition of ethanolamine phosphate to the second mannose plays an important role in cell separation via the GPI-based modification of daughter-specific proteins. {ECO:0000269|PubMed:10329735, ECO:0000269|PubMed:14985347, ECO:0000269|PubMed:15452134}. 2.-.-.- GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (Glycosylphosphatidylinositol-anchor biosynthesis protein 7) (Local anestheticum-sensitive protein 21) "LAS21, GPI7; mannose-ethanolamine phosphotransferase LAS21" Local Anestheticum Sensitive Phosphatidylethanolamine + G00141 <=> 1,2-Diacyl-sn-glycerol + G00151 5 out of 5 NA Phosphatidylethanolamine + G00141 <=> 1,2-Diacyl-sn-glycerol + G00151 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis." Glycosylphosphatidylinositol (GPI)-anchor biosynthesis NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" endoplasmic reticulum membrane -517 YJL126W "Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" 3.5.-.- Nit protein Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. {ECO:0000269|PubMed:28373563}. 3.5.1.- Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.-) (Nitrilase homolog 1) "NIT2; putative hydrolase" NA nitrilase NA NA NA NA NA "a nitrile + 2 H2O = a carboxylate + ammonium;indole-3-acetonitrile + 2 H2O => ammonium + indole-3-acetate" NA NA 4 out of 5 N-(4-oxoglutarate)-L-cysteinylglycine + H(2)O = 2-oxoglutarate + L-cysteinylglycine. {ECO:0000269|PubMed:28373563}. N-(4-oxoglutarate)-L-cysteinylglycine + H(2)O <=> 2-oxoglutarate + L-cysteinylglycine YES other NA "E263;H1023" NA NA NA indole-3-acetate biosynthesis V (bacteria and fungi) NA NA "cytoplasm;mitochondrion" "cytoplasm;mitochondrion" "mitochondrion;cytoplasm" -521 YJL140W "RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation" RNA polymerase II subunit B32 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex is necessary for promoter-directed transcription initiation but is not required for recruitment of Pol II to active preinitiation complexes and seems to be dispensable for transcription elongation and termination. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II. Involved in DNA repair of damage in the transcribed strand. RPB4 is dispensable under optimal growth conditions, but becomes essential during heat or cold shock and under nutrient depletion. Suppresses the RBP9-mediated transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER) but facilitates the RAD26-mediated TCR subpathway. Under stress conditions only, involved in mRNA export to the cytoplasm. Involved in mRNA decay. Promotes or enhances the deadenylation process of specific mRNAs and may recruit PAT1 and the LSM1-7 complex to these mRNAs, thus stimulating their decapping and further decay. {ECO:0000269|PubMed:11087726, ECO:0000269|PubMed:11382749, ECO:0000269|PubMed:12411509, ECO:0000269|PubMed:12857861, ECO:0000269|PubMed:15304220, ECO:0000269|PubMed:16357218, ECO:0000269|PubMed:1985924}. DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (B32) (DNA-directed RNA polymerase II 32 kDa polypeptide) "RPB4, CTF15; DNA-directed RNA polymerase II subunit RPB4" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA "nucleus;cytoplasm" "nucleus;cytoplasm" "nucleus;cytoplasm" -523 YJL148W "RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p" RNA polymerase I subunit A34.5 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. The heterodimer formed by RPA34 and RPA49 stimulates transcript elongation by Pol I. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:20797630, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184, ECO:0000269|PubMed:9121426}. DNA-directed RNA polymerase I subunit RPA34 (A34) (DNA-directed DNA-dependent RNA polymerase 34.5 kDa polypeptide) (A34.5) "RPA34, CST21; DNA-directed RNA polymerase I subunit RPA34" RNA Polymerase A a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus -526 YJL168C "Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia" 2.1.1.43 Histone methyltransferase with a role in transcriptional elongation Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent. {ECO:0000269|PubMed:11839797, ECO:0000269|PubMed:12629047, ECO:0000269|PubMed:12736296, ECO:0000269|PubMed:12773564, ECO:0000269|PubMed:12917322, ECO:0000269|PubMed:15798214, ECO:0000269|PubMed:16227595}. 2.1.1.43 Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.43) (Lysine N-methyltransferase 3) (SET domain-containing protein 2) "SET2, EZL1, KMT3; histone methyltransferase SET2" 2.1.1.43 SET domain-containing "EHMT1:EHMT2 methylates IL8 promoter;EHMT1:EHMT2 methylates IL8 promoter;EHMT1:EHMT2 methylates IL6 promoter;EHMT1:EHMT2 methylates IL6 promoter;eNoSC deacetylates histone H3;eNoSC dimethylates histone H3 at lysine-9;Formation of energy-dependent Nucleolar Silencing Complex (eNoSC);SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9);SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9);SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9);WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36);WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36);SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4);EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9);EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9);EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9);EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9);WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4);SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36);WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36);WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36);WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27);WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27);WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27);WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27);WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27);WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27);HERC2 and PIAS4 are recruited to DNA DSBs;ATM phosphorylates HERC2;PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs;HERC2 facilitates UBE2N:UBE2V2 binding to RNF8;RNF8 and RNF168 ubiquitinate H2AFX;WHSC1 dimethylates histone H4 on lysine K21 at DSBs;WHSC1 binds DNA DSBs;ATM phosphorylates WHSC1;ATM phosphorylates WHSC1;KDM4A,B bind H4K20Me2;RNF8 and RNF168 ubiquitinate KDM4A,B" "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" a [histone]-L-lysine + S-adenosyl-L-methionine => a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+ "Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine;S-Adenosyl-L-methionine + Histone-L-lysine <=> S-Adenosyl-L-homocysteine + Histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine" 5 out of 5 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. {ECO:0000255|PROSITE-ProRule:PRU00901}. S-adenosyl-L-methionine + L-lysine-[histone] <=> S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone] YES Lysine metabolism "pathway from kegg; reaction from uniprot; Lysine degradation was changed into lysine metabolism based on yeast 7.7" "H372;H974" Lysine degradation "Senescence-Associated Secretory Phenotype (SASP);PKMTs methylate histone lysines;SIRT1 negatively regulates rRNA expression;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "Lysine degradation;path:map00310" nucleus "nucleus;cytoplasm" nucleus -528 YJL180C "Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency" Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase Essential for the assembly of the mitochondrial F1-F0 complex. {ECO:0000269|PubMed:1826907}. Protein ATP12, mitochondrial "ATP12; ATP synthase complex assembly protein ATP12" ATP synthase ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] 3 out of 5 NA ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] YES Oxidative phosphorylation pathway from kegg superpathway of purine nucleotides de novo biosynthesis I // adenosine nucleotides de novo biosynthesis // adenosine ribonucleotides de novo biosynthesis NA mitochondrion "mitochondrion;mitochondrial membrane" mitochondrion -531 YJL200C "Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol" "4.2.1.-;4.2.1.3" Putative mitochondrial aconitase isozyme Catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. {ECO:0000269|PubMed:23106124}. 4.2.1.- Homocitrate dehydratase, mitochondrial (EC 4.2.1.-) (Aconitase 2) "ACO2; aconitate hydratase ACO2" aconitate hydratase "isocitrate <=> citrate;ACO1 binds 4Fe-4S;ACO1:4Fe-4S isomerises CIT to ISCIT;SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2;SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2;citrate <=> isocitrate" "citrate => isocitrate;isocitrate => citrate" "Citrate = cis-aconitate + H2O;(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O;citrate = isocitrate;isocitrate = cis-aconitate" "cis-aconitate + H2O <=> D-threo-isocitrate;citrate <=> cis-aconitate + H2O;citrate <=> D-threo-isocitrate" (R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O "isocitrate <=> citrate;citrate <=> isocitrate" 4 out of 5 (R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H(2)O. "(R)-2-hydroxybutane-1,2,4-tricarboxylate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O; citrate <=> isocitrate" YES "Lysine metabolism; Citrate cycle (TCA cycle)" "pathway from kegg and uniprot; Lysine biosynthesis was changed into lysine metabolism based on yeast7.7" H867 TCA cycle, aerobic respiration "PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 2/5." "Lysine biosynthesis;Metabolic pathways;Biosynthesis of antibiotics;2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids" glyoxylate cycle // TCA cycle, aerobic respiration "Citric acid cycle (TCA cycle);Iron uptake and transport" NA mitochondrion mitochondrion mitochondrion -533 YJR006W "Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia" 2.7.7.7 Subunit of DNA polymerase delta (polymerase III) DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. {ECO:0000269|PubMed:7567461}. 2.7.7.7 DNA polymerase delta small subunit (EC 2.7.7.7) (Hydroxyurea-sensitive protein 2) "POL31, HUS2, HYS2, SDP5; DNA-directed DNA polymerase delta subunit POL31" POLymerase "Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA synthesis. Pathway from kegg H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination" "Removal of the Flap Intermediate;Processive synthesis on the lagging strand" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus "nucleus;cytoplasm" nucleus -538 YJR040W "Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism" Voltage-gated chloride channel Anion/proton exchange transporter involved in iron and copper cation homeostasis. Involved in intracellular iron metabolism during growth on fermentable and non fermentable carbon sources. Required for proper copper-loading and maturation of multicopper oxidase FET3. Important for adjusting intracellular compartment pH to more alkaline pH under iron limitation. May also transport chloride ions through the plasma membrane. {ECO:0000269|PubMed:12074596, ECO:0000269|PubMed:17662057, ECO:0000269|PubMed:7505388, ECO:0000269|PubMed:9520490, ECO:0000269|PubMed:9614122}. "Anion/proton exchange transporter GEF1 (CLC protein GEF1) (ClC-A) (ClC-Y1) (Voltage-gated chloride channel) [Cleaved into: GEF1 N-terminal; GEF1 C-terminal]" "GEF1, CLC; Gef1p" Glycerol Ethanol, Ferric requiring "CLCN4/5/6 exchange Cl- for H+;CLCN4/5/6 exchange Cl- for H+;CLCN4/5/6 exchange Cl- for H+;CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region;CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region" "CLCN4/5/6 exchange Cl- for H+;CLCN4/5/6 exchange Cl- for H+;CLCN4/5/6 exchange Cl- for H+;CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region;CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region" 5 out of 5 NA Cl- <=> Cl- YES chloride transport Voltage-gated chloride channel Stimuli-sensing channels NA "Golgi membrane;cytoplasm" "Golgi membrane;vacuole;cytoplasm;endoplasmic reticulum;Golgi;cell envelope" "Golgi membrane;cytoplasm" -539 YJR043C "Third subunit of DNA polymerase delta; involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; forms a complex with Rev3p, Rev7p and Pol31p; interacts with Hys2p, PCNA (Pol30p), and Pol1p" Third subunit of DNA polymerase delta DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. DNA polymerase delta subunit 3 "POL32, REV5; DNA polymerase delta subunit POL32" POLymerase "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 NA 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination" NA nucleus nucleus nucleus -540 YJR051W "Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication" 1.3.1.6 Fumarate reductase, catalyzes the reduction of fumarate to succinate Irreversibly catalyzes the reduction of fumarate to succinate. Together with the second isozyme of soluble fumarate reductase (FRD1), essential for anaerobic growth. Involved in maintaining redox balance during oxygen deficiency conditions. Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2). {ECO:0000269|PubMed:12949191, ECO:0000269|PubMed:17345583, ECO:0000269|PubMed:9587404, ECO:0000269|PubMed:9711846}. 1.3.1.6 Fumarate reductase 2 (FRDS2) (EC 1.3.1.6) (NADH-dependent fumarate reductase) (Osmotic sensitivity protein 1) (Soluble fumarate reductase, mitochondrial isozyme) "OSM1; fumarate reductase" fumarate reductase (NADH) "NAD(+) + succinate => fumarate + H(+) + NADH;fumarate + H(+) + NADH => NAD(+) + succinate" succinate + NAD+ = fumarate + NADH + H+ "NAD(+) + succinate => fumarate + H(+) + NADH;fumarate + H(+) + NADH => NAD(+) + succinate" succinate + NAD+ = fumarate + NADH + H+ succinate + NAD+ = fumarate + NADH + H+ 5 out of 5 Succinate + NAD(+) = fumarate + NADH. {ECO:0000269|PubMed:9587404}. succinate + NAD+ <=> fumarate + NADH + H+ YES Carbon fixation pathways in prokaryotes required for the reoxidation of intracellular NADH under anaerobic conditions "Carbon fixation pathways in prokaryotes;path:map00720;Microbial metabolism in diverse environments;path:map01120" mitochondrion "mitochondrion;endoplasmic reticulum" mitochondrion -543 YJR063W "RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism" RNA polymerase I subunit A12.2 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. Proposed to contribute to the polymerase catalytic activity and form the polymerase active center together with the two largest subunits. Subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. Involved in transcriptional termination. {ECO:0000269|PubMed:15073335, ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerase I subunit RPA12 (A12) (A12.2) (DNA-directed RNA polymerase I 13.7 kDa polypeptide) "RPA12, RRN4; DNA-directed RNA polymerase I core subunit RPA12" RNA Polymerase A Binding of RRN3 to RNA Polymerase I a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation NA nucleus nucleus nucleus -545 YJR069C "Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA" "3.6.1.19;3.6.1.9" Nucleoside triphosphate pyrophosphohydrolase Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528, ECO:0000269|PubMed:17899088, ECO:0000269|PubMed:9918490}. 3.6.1.9 Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Hydroxylaminopurine sensitivity protein 1) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) "HAM1; nucleoside triphosphate pyrophosphohydrolase HAM1" 6-n-HydroxylAMinopurine sensitive "ITPA hydrolyses ITP to IMP;ITPA hydrolyses XTP to XMP;ITPA hydrolyses dITP to dIMP" "NA;dUTP + H2O => diphosphate + dUMP + H(+);diphosphate + dUMP + H(+) => dUTP + H2O;a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+);a ribonucleoside 5'-phosphate + diphosphate + H(+) => a ribonucleoside 5'-triphosphate + H2O;dATP + H2O => dAMP + diphosphate + H(+);dAMP + diphosphate + H(+) => dATP + H2O;dGTP + H2O => dGMP + diphosphate + H(+);dGMP + diphosphate + H(+) => dGTP + H2O;dTTP + H2O => diphosphate + dTMP + H(+);diphosphate + dTMP + H(+) => dTTP + H2O;a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+);a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O" "dITP + H2O = dIMP + diphosphate;XTP + H2O = XMP + diphosphate;ITP + H2O = IMP + diphosphate;dCTP + H2O = dCMP + diphosphate;FAD + H2O = AMP + FMN;NAD+ + H2O = AMP + NMN;dUTP + H2O = dUMP + diphosphate;ATP + H2O = AMP + diphosphate;a nucleoside triphosphate + H2O = a nucleotide + diphosphate;CTP + H2O = CMP + diphosphate;UTP + H2O = UMP + diphosphate;GDP-mannose + H2O = GMP + D-mannose 1-phosphate;ADP-glucose + H2O = AMP + alpha-D-glucose 1-phosphate;NADH + H2O = NMNH + AMP;ITP + H2O = IMP + diphosphate;GTP + H2O = GMP + diphosphate;dGTP + H2O = dGMP + diphosphate;TTP + H2O = TMP + diphosphate;UDP + H2O = UMP + phosphate;dCTP + H2O = dCDP + phosphate;ATP + 2 H2O = AMP + 2 phosphate;dATP + H2O = dAMP + diphosphate;bis(p-nitrophenyl)phosphate + H2O = p-nitrophenol + p-nitrophenylphosphate;ADP-ribose + H2O = AMP + alpha-D-ribose 1-phosphate;dGTP + H2O = dGDP + phosphate;dCDP + H2O = dCMP + phosphate;dGDP + H2O = dGMP + phosphate;adenosine 5'-diphosphate + H2O = AMP + phosphate;CDP + H2O = CMP + phosphate;UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate;nicotinic acid adenine dinucleotide + H2O = nicotinic acid mononucleotide + 5'-AMP;CDP-glucose + H2O = CMP + D-glucose-1-phosphate;Dephospho-CoA + H2O <=> Pantetheine 4'-phosphate + AMP;UDP-N-acetyl-alpha-D-glucosamine + H2O = UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate;UDP-alpha-D-galactose + H2O = UMP + alpha-D-galactose-1-phosphate;UDP-glucuronic acid + H2O = UMP + glucuronic acid phosphate;UDP-N-acetyl-alpha-D-galactosamine + H2O = N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP;NADPH + H2O = NMNH + adenosine 2',5'-phosphate;NADP+ + H2O = NMN + adenosine 2',5'-phosphate;diadenosine 5',5''-P1, P5-pentaposphate + H2O = ATP + ADP + AMP + adenosine 5'-tetraphosphate;3 diadenosine 5',5''-P1, P4-tetraphosphate + 3 H2O = 2 ATP + 2 ADP + 2 AMP;TDP-glucose + H2O = TMP + D-glucose-1-phosphate;2-nitrophenyl phosphate + H2O = 2-nitrophenol + phosphate;ADP-ribose + H2O = AMP + phosphoribose;alpha-NADH + H2O = alpha-NMNH + AMP;4-nitrophenyl-5'-TMP + H2O = 4-nitrophenol + 5'-TMP;diadenosine 5',5''-P1, P2-diphosphate + H2O = AMP + AMP;2',3'-cAMP + H2O = adenosine monophosphate" "dUTP + H2O => diphosphate + dUMP + H(+);diphosphate + dUMP + H(+) => dUTP + H2O;a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+);a ribonucleoside 5'-phosphate + diphosphate + H(+) => a ribonucleoside 5'-triphosphate + H2O;dATP + H2O => dAMP + diphosphate + H(+);dAMP + diphosphate + H(+) => dATP + H2O;dGTP + H2O => dGMP + diphosphate + H(+);dGMP + diphosphate + H(+) => dGTP + H2O;dTTP + H2O => diphosphate + dTMP + H(+);diphosphate + dTMP + H(+) => dTTP + H2O;a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+);a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O" "dCTP + H2O = dCMP + diphosphate;FAD + H2O = AMP + FMN;NAD+ + H2O = AMP + NMN;dUTP + H2O = dUMP + diphosphate;ATP + H2O = AMP + diphosphate;a nucleoside triphosphate + H2O = a nucleotide + diphosphate;CTP + H2O = CMP + diphosphate;UTP + H2O = UMP + diphosphate;GDP-mannose + H2O = GMP + D-mannose 1-phosphate;ADP-glucose + H2O = AMP + alpha-D-glucose 1-phosphate;NADH + H2O = NMNH + AMP;ITP + H2O = IMP + diphosphate;GTP + H2O = GMP + diphosphate;dGTP + H2O = dGMP + diphosphate;TTP + H2O = TMP + diphosphate;UDP + H2O = UMP + phosphate;dCTP + H2O = dCDP + phosphate;ATP + 2 H2O = AMP + 2 phosphate;dATP + H2O = dAMP + diphosphate;bis(p-nitrophenyl)phosphate + H2O = p-nitrophenol + p-nitrophenylphosphate;ADP-ribose + H2O = AMP + alpha-D-ribose 1-phosphate;dGTP + H2O = dGDP + phosphate;dCDP + H2O = dCMP + phosphate;dGDP + H2O = dGMP + phosphate;adenosine 5'-diphosphate + H2O = AMP + phosphate;CDP + H2O = CMP + phosphate;UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate;nicotinic acid adenine dinucleotide + H2O = nicotinic acid mononucleotide + 5'-AMP;CDP-glucose + H2O = CMP + D-glucose-1-phosphate;Dephospho-CoA + H2O <=> Pantetheine 4'-phosphate + AMP;UDP-N-acetyl-alpha-D-glucosamine + H2O = UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate;UDP-alpha-D-galactose + H2O = UMP + alpha-D-galactose-1-phosphate;UDP-glucuronic acid + H2O = UMP + glucuronic acid phosphate;UDP-N-acetyl-alpha-D-galactosamine + H2O = N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP;NADPH + H2O = NMNH + adenosine 2',5'-phosphate;NADP+ + H2O = NMN + adenosine 2',5'-phosphate;diadenosine 5',5''-P1, P5-pentaposphate + H2O = ATP + ADP + AMP + adenosine 5'-tetraphosphate;3 diadenosine 5',5''-P1, P4-tetraphosphate + 3 H2O = 2 ATP + 2 ADP + 2 AMP;TDP-glucose + H2O = TMP + D-glucose-1-phosphate;2-nitrophenyl phosphate + H2O = 2-nitrophenol + phosphate;ADP-ribose + H2O = AMP + phosphoribose;alpha-NADH + H2O = alpha-NMNH + AMP;4-nitrophenyl-5'-TMP + H2O = 4-nitrophenol + 5'-TMP;diadenosine 5',5''-P1, P2-diphosphate + H2O = AMP + AMP;2',3'-cAMP + H2O = adenosine monophosphate" "GTP + H2O <=> GMP + Diphosphate;ITP + H2O <=> IMP + Diphosphate;dGTP + H2O <=> dGMP + Diphosphate;dUTP + H2O <=> dUMP + Diphosphate;XTP + H2O <=> Xanthosine 5'-phosphate + Diphosphate;dITP + H2O <=> 2'-Deoxyinosine 5'-phosphate + Diphosphate;6-Mercaptopurine ribonucleoside triphosphate + H2O <=> 6-Thioinosine-5'-monophosphate + Diphosphate" 5 out of 5 A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528}. "dUTP + H2O => diphosphate + dUMP + H(+);a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+);dATP + H2O => dAMP + diphosphate + H(+);dGTP + H2O => dGMP + diphosphate + H(+);dTTP + H2O => diphosphate + dTMP + H(+);a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)" YES Purine metabolism "pathway from kegg; A nucleoside triphosphate + H2O = a nucleotide + diphospha from uniprot" "E77;E649;H222" "Purine metabolism;Metabolic pathways" Purine catabolism "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Starch and sucrose metabolism;path:map00500;Riboflavin metabolism;path:map00740;Nicotinate and nicotinamide metabolism;path:map00760;Pantothenate and CoA biosynthesis;path:map00770;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -548 YJR104C "Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex" 1.15.1.1 Cytosolic copper-zinc superoxide dismutase Destroys radicals which are normally produced within the cells and which are toxic to biological systems. 1.15.1.1 Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) "SOD1, CRS4; superoxide dismutase SOD1" 1.15.1.1 cytoplasmic superoxide dismutase "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular);SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular);SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol);CCS transfers Cu to SOD1;CCS transfers Cu to SOD1;CCS transfers Cu to SOD1;SOD1:Zn2+ binds CCS:Zn2+:2xCu1+;SOD1:Zn2+ binds CCS:Zn2+:2xCu1+;SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space);Release of platelet cytosolic components;Release of platelet cytosolic components;Secretion of SOD3;Secretion of SOD3;Secretion of SOD3;2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates;2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates" "2 H(+) + 2 superoxide => H2O2 + O2;H2O2 + O2 => 2 H(+) + 2 superoxide" 2 superoxide + 2 H+ = O2 + H2O2 "2 H(+) + 2 superoxide => H2O2 + O2;H2O2 + O2 => 2 H(+) + 2 superoxide" 2 superoxide + 2 H+ = O2 + H2O2 2 superoxide + 2 H+ => hydrogen peroxide + oxygen 5 out of 5 2 superoxide + 2 H(+) = O(2) + H(2)O(2). 2 superoxide + 2 H+ => hydrogen peroxide + oxygen YES Peroxisome pathway from kegg "E398;H537" removal of superoxide radicals "Peroxisome;Longevity regulating pathway - multiple species" superoxide radicals degradation // ethylene biosynthesis "Platelet degranulation ;Detoxification of Reactive Oxygen Species" NA "cytoplasm;mitochondrial membrane" "nucleus;cytoplasm;mitochondrion;mitochondrial membrane" "mitochondrial membrane;cytoplasm" -549 YJR117W "Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves both isoprenylated and non-prenylated oligopeptides; contains multiple transmembrane spans; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and can complement yeast null mutant" 3.4.24.84 Highly conserved zinc metalloprotease Proteolytically removes the C-terminal three residues of farnesylated A-factor mating pheromone. Also acts to cleave the N-terminal extension of the pheromone. Does not act on Ras. {ECO:0000269|PubMed:10692417, ECO:0000269|PubMed:9015299, ECO:0000269|PubMed:9065405, ECO:0000269|PubMed:9700155, ECO:0000269|PubMed:9725832}. 3.4.24.84 CAAX prenyl protease 1 (EC 3.4.24.84) (A-factor-converting enzyme) (Prenyl protein-specific endoprotease 1) (PPSEP 1) "STE24, AFC1, PIO2; zinc metalloprotease" 3.4.24.84 CAAX prenyl protease 1 NA NA "S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide;farnesylated protein that ends with a CAAX sequence + H2O = [protein] C-terminal S-farnesyl-L-cysteine + peptide + H+;a-factor-CaaX + H2O = a-factor + aaX;a-factor-CaaX + H2O = a-factor-C + aaX;a-factor + H2O = fragments of a-factor" NA "S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide;farnesylated protein that ends with a CAAX sequence + H2O = [protein] C-terminal S-farnesyl-L-cysteine + peptide + H+;a-factor-CaaX + H2O = a-factor + aaX;a-factor-CaaX + H2O = a-factor-C + aaX;a-factor + H2O = fragments of a-factor" a farnesylated protein that ends with a CAAX sequence + H2O => a [protein] C-terminal S-farnesyl-L-cysteine + a peptide + H+ S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide NA 5 out of 5 The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids. S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide YES Terpenoid backbone biosynthesis pathway from kegg NA NA NA "Terpenoid backbone biosynthesis;Biosynthesis of antibiotics" NA NA "Terpenoid backbone biosynthesis;path:map00900;Biosynthesis of antibiotics;path:map01130" endoplasmic reticulum membrane "nucleus;mitochondrial membrane;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -550 YJR131W "Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation" 3.2.1.113 Alpha-1,2-mannosidase Involved in glycoprotein quality control as it is important for the targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations it further trims the carbohydrates to Man(5)GlcNAc(2). {ECO:0000269|PubMed:12090241}. 3.2.1.113 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Man(9)-alpha-mannosidase) "MNS1; mannosyl-oligosaccharide 1,2-alpha-mannosidase" 3.2.1.113 "mannosyl-oligosaccharide 1,2-α-mannosidase" "MAN1B1 hydrolyses 1,2-linked mannose (a branch);MAN1B1 hydrolyses a second 1,2-linked mannose (a branch);MAN1B1 hydrolyses 1,2-linked mannose (c branch);MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch);Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2" "2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn + 4 H2O <=> alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn + 4 D-Mannose;H2O + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O = (Man)5GlcNAc + 4 D-mannose;Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O = Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 D-mannose;Manalpha(1-2)Manalpha(1-3)Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 2 H2O = (Man)5GlcNAc + 2 D-mannose;alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + H2O = alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose;Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O = Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + D-mannose" "2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn + 4 H2O <=> alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn + 4 D-Mannose;H2O + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O = (Man)5GlcNAc + 4 D-mannose;Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O = Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 D-mannose;Manalpha(1-2)Manalpha(1-3)Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 2 H2O = (Man)5GlcNAc + 2 D-mannose;alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + H2O = alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose;Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O = Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + D-mannose" a [protein]-L-asparagine-[(mannosyl)9(N-acetylglucosaminyl)2] + H2O => a [protein]-L-asparagine-[(mannosyl)8(N-acetylglucosaminyl)2] + beta-D-mannopyranose "G00011 + 4 H2O <=> G00012 + 4 D-Mannose;H2O + G00011 <=> D-Mannose + G10694" 5 out of 5 Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). {ECO:0000269|PubMed:12090241}. "G00011 + 4 H2O <=> G00012 + 4 D-Mannose;H2O + G00011 <=> D-Mannose + G10694" YES N-Glycan biosynthesis pathway from kegg H405 "PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:12090241}." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (yeast) processing in the ER "ER Quality Control Compartment (ERQC);Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2" "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -551 YJR149W "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" 1.13.12.16 Putative protein of unknown function Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites. {ECO:0000250}. 1.13.12.16 Putative nitronate monooxygenase (EC 1.13.12.16) (Nitroalkane oxidase) putative nitronate monooxygenase 1.13.12.16 Unknown NA NA "ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O;ethylnitronate + oxygen = acetaldehyde + nitrite + [unspecified degradation products];3-aci-nitropropanoate + oxygen = 3-oxopropanoate + nitrite + [unspecified degradation products];ethylnitronate + O2 = acetaldehyde + nitrite + other products" NA "ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O;ethylnitronate + oxygen = acetaldehyde + nitrite + [unspecified degradation products];3-aci-nitropropanoate + oxygen = 3-oxopropanoate + nitrite + [unspecified degradation products];ethylnitronate + O2 = acetaldehyde + nitrite + other products" NA Ethylnitronate + Oxygen + Reduced FMN <=> Acetaldehyde + Nitrite + FMN + H2O NA 3 out of 5 Ethylnitronate + O(2) = acetaldehyde + nitrite + other products. Ethylnitronate + Oxygen + Reduced FMN <=> Acetaldehyde + Nitrite + FMN + H2O YES Nitrogen metabolism pathway from kegg NA NA NA Nitrogen metabolism NA NA "Nitrogen metabolism;path:map00910" cytoplasm cytoplasm cytoplasm -552 YJR155W "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" Putative aryl-alcohol dehydrogenase 1.1.1.- Putative aryl-alcohol dehydrogenase AAD10 (EC 1.1.1.-) "AAD10; putative aryl-alcohol dehydrogenase" aryl-alcohol dehydrogenase "3-chlorobenzyl alcohol + NAD+ = 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ = 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ = 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ = p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ = 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ = an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ = benzaldehyde + NADH + H+" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism "pathway from E.coli model; reaction from biocyc" "E646;E743;H1286" NA -553 YJR156C "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" Protein involved in synthesis of the thiamine precursor HMP Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. {ECO:0000250|UniProtKB:P43534}. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI11 (HMP-P synthase) (Hydroxymethylpyrimidine phosphate synthase) (Thiamine biosynthesis protein 11) (Thiamine pyrimidine synthase) "THI11; 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" MONOMER3O-9135 [an HMP-P synthase]-L-histidine + pyridoxal 5'-phosphate => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + an HMP-P synthase Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine 3 out of 5 NA Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine YES Thiamine metabolism pathway from kegg thiamine biosynthesis "PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000305|PubMed:12777485}." "Thiamine metabolism;Metabolic pathways" superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis NA -554 YLL001W "Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur; participates in endocytosis and regulates peroxisome fission along with Vps1p; mutants in the human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy" 3.6.5.5 Dynamin-related GTPase involved in mitochondrial organization Microtubule-associated force-producing protein that participates mitochondrial fission. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Functions antagonistically with FZO1. {ECO:0000269|PubMed:10559943, ECO:0000269|PubMed:23530241}. 3.6.5.5 Dynamin-related protein DNM1 (EC 3.6.5.5) "DNM1; dynamin-related GTPase DNM1" 3.6.5.5 DyNaMin-related "Mitochondrial recruitment of Drp1;Mitochondrial recruitment of Drp1" NA GTP + H2O = GDP + phosphate NA GTP + H2O = GDP + phosphate NA NA NA 5 out of 5 GTP + H(2)O = GDP + phosphate. GTP + H(2)O = GDP + phosphate YES Nucleotide Salvage Pathway from e.coli NA E450 NA NA Mitophagy - yeast NA Apoptotic execution phase NA "mitochondrial membrane;cytoplasm" "mitochondrion;mitochondrial membrane;peroxisome;cytoplasm" "mitochondrial membrane;cytoplasm" -559 YLL051C "Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels" 1.16.1.9 Putative ferric reductase with similarity to Fre2p Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol. Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol. {ECO:0000269|PubMed:17553781, ECO:0000269|PubMed:17681937}. 1.16.1.9 Ferric reductase transmembrane component 6 (EC 1.16.1.9) (Ferric-chelate reductase 6) "FRE6; putative ferric-chelate reductase" Ferric REductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" NA vacuolar membrane "vacuole;vacuolar membrane;cell envelope" vacuolar membrane -562 YLL058W "Putative protein of unknown function with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene" 2.5.1.48 Putative protein of unknown function with similarity to Str2p Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity). {ECO:0000250}. 2.5.1.48 Putative cystathionine gamma-synthase YLL058W (EC 2.5.1.48) (O-succinylhomoserine (thiol)-lyase) cystathionine gamma-synthase 2.5.1.48 Unknown "O-succinyl-L-homoserine + L-cysteine => L-cystathionine + H(+) + succinate;L-cystathionine + H(+) + succinate => O-succinyl-L-homoserine + L-cysteine" "O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate;O-succinyl-L-homoserine + H2O = succinate + 2-oxobutyrate + NH3;O-succinyl-L-homoserine + H2S = L-homocysteine + succinate;O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate;O-acetyl-L-homoserine + L-cysteine = L-cystathionine + acetate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate;O-succinyl-L-homoserine + L-cysteine = O-acetyl-L-homocysteine + L-cysteine;O-succinyl-L-homoserine + L-selenocysteine = selenocystathionine + succinate" "O-succinyl-L-homoserine + L-cysteine => L-cystathionine + H(+) + succinate;L-cystathionine + H(+) + succinate => O-succinyl-L-homoserine + L-cysteine" "O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate;O-succinyl-L-homoserine + H2O = succinate + 2-oxobutyrate + NH3;O-succinyl-L-homoserine + H2S = L-homocysteine + succinate;O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate;O-acetyl-L-homoserine + L-cysteine = L-cystathionine + acetate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate;O-succinyl-L-homoserine + L-cysteine = O-acetyl-L-homocysteine + L-cysteine;O-succinyl-L-homoserine + L-selenocysteine = selenocystathionine + succinate" "O-Succinyl-L-homoserine + H2O <=> 2-Oxobutanoate + Succinate + Ammonia;O-Succinyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Succinate;Cystathionine + Succinate <=> O-Succinyl-L-homoserine + L-Cysteine;O-Acetyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Acetate;O-Succinyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Succinate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate" 3 out of 5 O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate. "L-cysteine + O-succinyl-L-homoserine => succinate + L-cystathionine + H+;O-succinyl-L-homoserine + H2O => 2-oxobutanoate + succinate + ammonium + H+" YES Cysteine and methionine metabolism pathway from kegg E470 "PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1." "Cysteine and methionine metabolism;Selenocompound metabolism;Sulfur metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Biosynthesis of amino acids" "Cysteine and methionine metabolism;path:map00270;Selenocompound metabolism;path:map00450;Sulfur metabolism;path:map00920;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Biosynthesis of antibiotics;path:map01130" cytoplasm -563 YLL060C "Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress" 2.5.1.18 Glutathione S-transferase capable of homodimerization NA 2.5.1.18 Glutathione S-transferase 2 (EC 2.5.1.18) (GST-II) "GTT2; glutathione transferase GTT2" NA glutathione transferase NA "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+;glutathione + 4-hydroxy-2-nonenal = 4-hydroxy-2-nonenal-glutathione conjugate;glutathione + RX = a glutathione-toxin conjugate + HX" NA NA 4 out of 5 RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:19851333}. RX + glutathione = HX + R-S-glutathione YES Glutathione metabolism "pathway from kegg; reaction from uniprot" "H675;H1101" glutathione-glutaredoxin redox reactions NA NA NA NA "Glutathione metabolism;path:map00480;Metabolism of xenobiotics by cytochrome P450;path:map00980;Drug metabolism - cytochrome P450;path:map00982" mitochondrion -567 YLR047C "Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p" 1.16.1.7 Protein with sequence similarity to iron/copper reductases Required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates (By similarity). Involved in iron homeostasis. {ECO:0000250, ECO:0000269|PubMed:14534306}. 1.16.1.7 Probable ferric reductase transmembrane component 8 (EC 1.16.1.7) (Ferric-chelate reductase 8) "FRE8; putative ferric-chelate reductase" FRE8 "2 a Fe(II)-siderophore + H(+) + NAD(+) => 2 a Fe(III)-siderophore + NADH;2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)" "2 Fe(II)-siderophore + NAD+ + H+ = 2 Fe(III)-siderophore + NADH;NADH + Fe3+ = NAD+ + Fe2+" "2 a Fe(II)-siderophore + H(+) + NAD(+) => 2 a Fe(III)-siderophore + NADH;2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)" "2 Fe(II)-siderophore + NAD+ + H+ = 2 Fe(III)-siderophore + NADH;NADH + Fe3+ = NAD+ + Fe2+" 4 out of 5 2 Fe(II)-siderophore + NAD(+) + H(+) = 2 Fe(III)-siderophore + NADH. 2 a Fe(III)-siderophore + NADPH <=> 2 a Fe(II)-siderophore + H(+) + NADP(+) YES ferric-chelate reductase no pathway from database NA "vacuole;endoplasmic reticulum" -568 YLR057W "Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene" 3.2.1.- Putative mannosidase involved in ER-associated protein degradation Putative mannosidase involved in glycoprotein quality control since it is involved in the targeting of misfolded glycoproteins for ER-associated protein degradation (ERAD). {ECO:0000269|PubMed:21971548}. 3.2.1.- Putative endoplasmic reticulum mannosidase MNL2 (EC 3.2.1.-) (Mannosidase-like protein 2) "MNL2; putative mannosidase MNL2" 3.2.1.113 MaNnosidase-Like protein "G00011 + 4 H2O <=> G00012 + 4 D-Mannose;H2O + G00011 <=> D-Mannose + G10694" 4 out of 5 NA "G00011 + 4 H2O <=> G00012 + 4 D-Mannose;H2O + G00011 <=> D-Mannose + G10694" YES N-Glycan biosynthesis pathway from kegg "PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P32906}." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" NA endoplasmic reticulum membrane "Golgi membrane;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -571 YLR099C "Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication; human ABHD5 can complement ict1 null mutant" 2.3.1.51 Lysophosphatidic acid acyltransferase Lysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper. {ECO:0000269|PubMed:10628851, ECO:0000269|PubMed:11055939, ECO:0000269|PubMed:18252723, ECO:0000269|PubMed:9717239}. 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase ICT1 (EC 2.3.1.51) (Increased copper tolerance protein 1) (Lysophosphatidic acid acyltransferase ICT1) (LPAAT) "ICT1; lysophosphatidic acid acyltransferase ICT1" Increased Copper Tolerance ABHD4 hydrolyses NAPE "1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA;a 1,2-diacyl-sn-glycero-3-phosphate + CoA => 1-acyl-sn-glycero-3-phosphate + an acyl-CoA" "acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate;palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate;acyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate;1-oleoyl-sn-glycerol-3-phosphate + oleoyl-CoA = CoA + 1,2-oleoyl-sn-glycerol-3-phosphate;2,3-Dehydroacyl-CoA + 1-Acyl-sn-glycerol 3-phosphate <=> CoA + Phosphatidate;palmitoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];long-chain acyl-[acyl-carrier protein] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl 2-acyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];stearoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-stearoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];oleoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];18-hydroxylinoleoyl-CoA + 1-[18-hydroxyoleyl]-2-lyso-phosphatidate = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + coenzyme A;palmitoleoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-CoA + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];myristoyl-CoA + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + coenzyme A;myristoyl-[acp] + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + holo-[acyl-carrier protein];1-palmitoylglycerol 3-phosphate + myristoyl-CoA = 1-palmitoyl-2-myristoyl phosphatidate + coenzyme A;1-palmitoylglycerol 3-phosphate + myristoyl-[acp] = 1-palmitoyl-2-myristoyl phosphatidate + holo-[acyl-carrier protein];long-chain acyl-CoA + 1-alkyl-sn-glycerol 3-phosphate = 2-acyl-1-alkyl-sn-glycerol 3-phosphate + coenzyme A;2,3,4-saturated fatty acyl-[acp] + 2,3,4-saturated 2-lysophosphatidate = 2,3,4-saturated L-phosphatidate + holo-[acyl-carrier protein];palmitoyl-[acp] + 1-palmitoylglycerol 3-phosphate = dipalmitoyl phosphatidate + holo-[acyl-carrier protein];oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol = CoA + 1,2-dioleoyl-sn-phosphatidylinositol;myristoyl-CoA + 1-myristoyl-sn-glycerol 3-phosphate = CoA + 1,2-dimyristoyl-sn-glycerol 3-phosphate;lauroyl-CoA + 1-lauroyl-sn-glycerol 3-phosphate = CoA + 1,2-dilauroyl-sn-glycerol 3-phosphate;arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate" "1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA;a 1,2-diacyl-sn-glycero-3-phosphate + CoA => 1-acyl-sn-glycero-3-phosphate + an acyl-CoA" "acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate;palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate;acyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate;1-oleoyl-sn-glycerol-3-phosphate + oleoyl-CoA = CoA + 1,2-oleoyl-sn-glycerol-3-phosphate;2,3-Dehydroacyl-CoA + 1-Acyl-sn-glycerol 3-phosphate <=> CoA + Phosphatidate;palmitoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];long-chain acyl-[acyl-carrier protein] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl 2-acyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];stearoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-stearoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];oleoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];18-hydroxylinoleoyl-CoA + 1-[18-hydroxyoleyl]-2-lyso-phosphatidate = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + coenzyme A;palmitoleoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-CoA + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];myristoyl-CoA + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + coenzyme A;myristoyl-[acp] + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + holo-[acyl-carrier protein];1-palmitoylglycerol 3-phosphate + myristoyl-CoA = 1-palmitoyl-2-myristoyl phosphatidate + coenzyme A;1-palmitoylglycerol 3-phosphate + myristoyl-[acp] = 1-palmitoyl-2-myristoyl phosphatidate + holo-[acyl-carrier protein];long-chain acyl-CoA + 1-alkyl-sn-glycerol 3-phosphate = 2-acyl-1-alkyl-sn-glycerol 3-phosphate + coenzyme A;2,3,4-saturated fatty acyl-[acp] + 2,3,4-saturated 2-lysophosphatidate = 2,3,4-saturated L-phosphatidate + holo-[acyl-carrier protein];palmitoyl-[acp] + 1-palmitoylglycerol 3-phosphate = dipalmitoyl phosphatidate + holo-[acyl-carrier protein];oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol = CoA + 1,2-dioleoyl-sn-phosphatidylinositol;myristoyl-CoA + 1-myristoyl-sn-glycerol 3-phosphate = CoA + 1,2-dimyristoyl-sn-glycerol 3-phosphate;lauroyl-CoA + 1-lauroyl-sn-glycerol 3-phosphate = CoA + 1,2-dilauroyl-sn-glycerol 3-phosphate;arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate" ABHD4 hydrolyses NAPE 3 out of 5 Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate <=> CoA + 1,2-diacyl-sn-glycerol 3-phosphate YES "Glycerolipid metabolism;Glycerophospholipid metabolism" pathway from kegg "E705;H70;H787" Acyl chain remodelling of PE "Glycerolipid metabolism;path:map00561;Glycerophospholipid metabolism;path:map00564;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" -576 YLR143W "Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene" 6.3.1.14 Diphthamide synthetase Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EFT1 or EFT2) to diphthamide. {ECO:0000269|PubMed:23169644, ECO:0000269|PubMed:23468660}. 6.3.1.14 Diphthine--ammonia ligase (EC 6.3.1.14) (Diphthamide synthase) (Diphthamide synthetase) "DPH6; diphthine--ammonia ligase" 6.3.1.14 "diphthine—ammonia ligase" DPH6 ligates ammonium to diphthine-EEF2 "ATP + diphthine-[translation elongation factor 2] + NH4(+) => AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+);AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) => ATP + diphthine-[translation elongation factor 2] + NH4(+)" ATP + Peptide diphthine + Ammonia + H+ <=> AMP + Diphosphate + Peptide diphthamide "ATP + diphthine-[translation elongation factor 2] + NH4(+) => AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+);AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) => ATP + diphthine-[translation elongation factor 2] + NH4(+)" ATP + Peptide diphthine + Ammonia + H+ <=> AMP + Diphosphate + Peptide diphthamide a diphthine-[translation elongation factor 2] + ammonium + ATP => a diphthamide-[translation elongation factor 2] + AMP + diphosphate + H+ ATP + Peptide diphthine + Ammonia + H+ <=> AMP + Diphosphate + Peptide diphthamide 4 out of 5 ATP + diphthine-[translation elongation factor 2] + NH(3) = AMP + diphosphate + diphthamide-[translation elongation factor 2]. {ECO:0000269|PubMed:23169644}. ATP + Peptide diphthine + Ammonia + H+ <=> AMP + Diphosphate + Peptide diphthamide YES diphthamide biosynthesis pathway from biocyc "PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. {ECO:0000269|PubMed:23169644}." diphthamide biosynthesis Synthesis of diphthamide-EEF2 NA cytoplasm cytoplasm cytoplasm -578 YLR151C "8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1" 3.6.1.55 8-oxo-dGTP diphosphatase " Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine. Has a strong preference for oxidized CoA disulfide (CoASSCoA) as substrate. May be required to remove potentially toxic oxidized CoA disulfide to maintain the capacity for beta-oxidation of fatty acids. Can degrade 8-oxo-dGTP in vitro; however, such activity may not be relevant in vivo." 3.6.1.55 Peroxisomal coenzyme A diphosphatase 1, peroxisomal (EC 3.6.1.55) "PCD1; 8-oxo-dGTP diphosphatase" NA peroxisomal nudix hydrolase NA "8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+);8-oxo-dGMP + diphosphate + H(+) => 8-oxo-dGTP + H2O" "8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate;GTP + H2O = GMP + diphosphate;dGTP + H2O = dGMP + diphosphate;8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate;8-oxo-GDP + H2O = 8-oxo-GMP + phosphate;dGDP + H2O = dGMP + phosphate" "8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+);8-oxo-dGMP + diphosphate + H(+) => 8-oxo-dGTP + H2O" "8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate;GTP + H2O = GMP + diphosphate;dGTP + H2O = dGMP + diphosphate;8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate;8-oxo-GDP + H2O = 8-oxo-GMP + phosphate;dGDP + H2O = dGMP + phosphate" NA NA NA 5 out of 5 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate. {ECO:0000269|PubMed:10922370}. 8-oxo-dGTP + H(2)O <=> 8-oxo-dGMP + diphosphate YES other NA NA NA NA NA NA NA NA peroxisome "peroxisome;cytoplasm" peroxisome -580 YLR164W "Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p" Putative alternate subunit of succinate dehydrogenase (SDH) Homolog of SDH4, but seems not to be a stoichiometric subunit of either the succinate dehydrogenase (SDH) complex or the mitochondrial inner membrane translocase TIM22 complex. {ECO:0000303|PubMed:22152483}. Mitochondrial inner membrane protein SHH4 (SDH4 homolog) "SHH4; protein SHH4" SDH4 Homolog Quinone + Succinate <=> Hydroquinone + Fumarate 4 out of 5 NA Quinone + Succinate <=> Hydroquinone + Fumarate YES Citrate cycle (TCA cycle) pathway from kegg "Citrate cycle (TCA cycle);Oxidative phosphorylation;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism" NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -587 YLR214W "Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels" 1.16.1.9 Ferric reductase and cupric reductase Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake. {ECO:0000269|PubMed:11120744, ECO:0000269|PubMed:12954629, ECO:0000269|PubMed:1431884, ECO:0000269|PubMed:1570306, ECO:0000269|PubMed:7814363, ECO:0000269|PubMed:8662826, ECO:0000269|PubMed:8662973, ECO:0000269|PubMed:9153234}. 1.16.1.9 Ferric/cupric reductase transmembrane component 1 (EC 1.16.1.9) (Ferric-chelate reductase 1) "FRE1; ferric/cupric-chelate reductase" ferric reductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+;2 an Fe(III)-siderophore + NADPH => 2 Fe2+ + 2 a siderophore + NADP+ + H+;2 ferric (2,3-dihydroxybenzoylserine)3 + NADPH + 9 H+ => 2 Fe2+ + 2 (2,3-dihydroxybenzoylserine)3 + NADP+" 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. {ECO:0000269|PubMed:11120744, ECO:0000269|PubMed:1431884, ECO:0000269|PubMed:15288128, ECO:0000269|PubMed:8662826, ECO:0000269|PubMed:8662973}. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope cell envelope cell envelope -590 YLR239C "Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups" 2.3.1.181 Lipoyl ligase Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). {ECO:0000250}. 2.3.1.181 Octanoyltransferase, mitochondrial (EC 2.3.1.181) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase) "LIP2; lipoyl(octanoyl) transferase LIP2" 2.3.1.181 octanoyl transferase LIPT2 transfers octanoyl group to GCSH "[protein]-L-lysine + octanoyl-[ACP] => [protein]-N(6)-octanoyl-L-lysine + H(+) + holo-[ACP];[protein]-N(6)-octanoyl-L-lysine + H(+) + holo-[ACP] => [protein]-L-lysine + octanoyl-[ACP]" "octanoyl-[acyl-carrier protein] + protein = protein 6-N-(octanoyl)lysine + acyl carrier protein;Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein;octanoyl-[acp] + [glycine cleavage system lipoyl-carrier protein]-L-lysine = [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + holo-[acyl-carrier protein] + H+;octanoyl-[acp] + [lipoyl-carrier protein]-L-lysine = [lipoyl-carrier protein] N6-octanoyl-L-lysine + holo-[acyl-carrier protein] + H+;an octanoyl-[acyl-carrier protein] + glycine cleavage system protein = glycine cleavage system protein-N6-(octanoyl)lysine + an [acyl-carrier protein];octanoyl-[acyl-carrier protein] + apo-H protein = APO H-protein N6-(octanoyl)lysine + acyl-carrier protein" "[protein]-L-lysine + octanoyl-[ACP] => [protein]-N(6)-octanoyl-L-lysine + H(+) + holo-[ACP];[protein]-N(6)-octanoyl-L-lysine + H(+) + holo-[ACP] => [protein]-L-lysine + octanoyl-[ACP]" "octanoyl-[acyl-carrier protein] + protein = protein 6-N-(octanoyl)lysine + acyl carrier protein;Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein;octanoyl-[acp] + [glycine cleavage system lipoyl-carrier protein]-L-lysine = [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + holo-[acyl-carrier protein] + H+;octanoyl-[acp] + [lipoyl-carrier protein]-L-lysine = [lipoyl-carrier protein] N6-octanoyl-L-lysine + holo-[acyl-carrier protein] + H+;an octanoyl-[acyl-carrier protein] + glycine cleavage system protein = glycine cleavage system protein-N6-(octanoyl)lysine + an [acyl-carrier protein];octanoyl-[acyl-carrier protein] + apo-H protein = APO H-protein N6-(octanoyl)lysine + acyl-carrier protein" "an octanoyl-[acp] + a [lipoyl-carrier protein]-L-lysine => a [lipoyl-carrier protein] N6-octanoyl-L-lysine + a holo-[acyl-carrier protein] + H+;an octanoyl-[acp] + [glycine cleavage system lipoyl-carrier protein]-L-lysine => a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + a holo-[acyl-carrier protein] + H+" "Octanoyl-[acp] + Apoprotein <=> Protein N6-(octanoyl)lysine + Acyl-carrier protein;Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein" NA 4 out of 5 Octanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein]. "Octanoyl-[acp] + Apoprotein <=> Protein N6-(octanoyl)lysine + Acyl-carrier protein;Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein" YES Lipoic acid metabolism pathway from kegg "H1034;H1035" NA "PATHWAY: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2." "Lipoic acid metabolism;Metabolic pathways" superpathway of lipoate biosynthesis and incorporation (PDH, KGDH, GCV) // lipoate biosynthesis and incorporation (glycine cleavage system) // lipoate biosynthesis and incorporation I Glyoxylate metabolism and glycine degradation "Lipoic acid metabolism;path:map00785;Metabolic pathways;path:map01100" mitochondrion mitochondrion mitochondrion -591 YLR244C "Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p" 3.4.11.18 Methionine aminopeptidase Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays the major role in N-terminal methionine removal. Less efficient when the second residue is Val. {ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:11811952, ECO:0000269|PubMed:11968008, ECO:0000269|PubMed:12874831, ECO:0000269|PubMed:7862096}. 3.4.11.18 Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1) "MAP1; methionine aminopeptidase MAP1" 3.4.11.18 methionine aminopeptidase METAP1/2 demethylates GNAT1 "Met-Ala + H2O = Met + Ala;N-terminal-L-methionyl-L-alanyl-[protein] + H2O = N-terminal L-alanyl-[protein] + L-methionine;N-terminal-L-methionyl-L-cysteinyl-[protein] + H2O = N-terminal cysteinyl-[protein] + L-methionine;N-terminal-L-methionyl-glycyl-[protein] + H2O = N-terminal glycyl-[protein] + L-methionine;N-terminal-L-methionyl-L-seryl-[protein] + H2O = N-terminal L-seryl-[protein] + L-methionine;N-terminal-L-methionyl-L-threonyl-[protein] + H2O = N-terminal L-threonyl-[protein] + L-methionine;N-terminal-L-methionyl-L-valyl-[protein] + H2O = N-terminal L-valyl-[protein] + L-methionine;Met-peptide + H2O = Met + peptide" "Met-Ala + H2O = Met + Ala;N-terminal-L-methionyl-L-alanyl-[protein] + H2O = N-terminal L-alanyl-[protein] + L-methionine;N-terminal-L-methionyl-L-cysteinyl-[protein] + H2O = N-terminal cysteinyl-[protein] + L-methionine;N-terminal-L-methionyl-glycyl-[protein] + H2O = N-terminal glycyl-[protein] + L-methionine;N-terminal-L-methionyl-L-seryl-[protein] + H2O = N-terminal L-seryl-[protein] + L-methionine;N-terminal-L-methionyl-L-threonyl-[protein] + H2O = N-terminal L-threonyl-[protein] + L-methionine;N-terminal-L-methionyl-L-valyl-[protein] + H2O = N-terminal L-valyl-[protein] + L-methionine;Met-peptide + H2O = Met + peptide" a peptide with an N-terminal L-methionine + H2O => L-methionine + a peptide + H+ 5 out of 5 Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. {ECO:0000255|HAMAP-Rule:MF_03174}. Met-Ala + H2O <=> Met + Ala YES Hydrolysis of peptide bond no pathway from database Inactivation, recovery and regulation of the phototransduction cascade NA cytoplasm cytoplasm cytoplasm -597 YLR286C "Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p" 3.2.1.14 Endochitinase Chitinase is required for cell separation during growth of Saccharomyces cerevisiae. 3.2.1.14 Endochitinase (EC 3.2.1.14) (Soluble cell wall protein 2) "CTS1, SCW2; Cts1p" 3.2.1.14 endochitinase "GlcNAc beta(1-4)GlcNAc + H2O = N-acetyl-D-glucosamine + N-acetyl-D-glucosamine;Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin;beta-1,4-Poly-N-acetyl-D-glucosamine(n+2) + H2O <=> Chitobiose + beta-1,4-Poly-N-acetyl-D-glucosamine(n);N,N',N'',N''',N''''-pentaacetylchitopentaose + H2O = N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;solid beta-chitin + H2O = N,N'-diacetylchitobiose;N-acetylglucosamine oligomers + H2O = N-acetylglucosamine;chitosan + H2O = chitosan oligosaccharides;chitopentaose + H2O = chitobiose + chitotriose" "GlcNAc beta(1-4)GlcNAc + H2O = N-acetyl-D-glucosamine + N-acetyl-D-glucosamine;Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin;beta-1,4-Poly-N-acetyl-D-glucosamine(n+2) + H2O <=> Chitobiose + beta-1,4-Poly-N-acetyl-D-glucosamine(n);N,N',N'',N''',N''''-pentaacetylchitopentaose + H2O = N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;solid beta-chitin + H2O = N,N'-diacetylchitobiose;N-acetylglucosamine oligomers + H2O = N-acetylglucosamine;chitosan + H2O = chitosan oligosaccharides;chitopentaose + H2O = chitobiose + chitotriose" "a chitodextrin + n H2O => n N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;chitin + H2O => 2 a chitodextrin" "Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin" 5 out of 5 Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. "Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin" YES Amino sugar and nucleotide sugar metabolism pathway from kegg "H142;H1198" "Amino sugar and nucleotide sugar metabolism;Metabolic pathways" "Amino sugar and nucleotide sugar metabolism;path:map00520;Metabolic pathways;path:map01100" cell envelope "vacuole;extracellular;cell envelope;nucleus;endoplasmic reticulum" cell envelope -601 YLR345W "Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene" "2.7.1.105;3.1.3.46" Similar to 6-phosphofructo-2-kinase enzymes Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000250}. "2.7.1.105; 3.1.3.46" "Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase "2.7.1.105;3.1.3.46" putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase "beta-D-fructose 6-phosphate + ATP => beta-D-fructose 2,6-bisphosphate + ADP + H(+);beta-D-fructose 2,6-bisphosphate + ADP + H(+) => beta-D-fructose 6-phosphate + ATP;beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate;beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O" "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate;beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate" "beta-D-fructose 6-phosphate + ATP => beta-D-fructose 2,6-bisphosphate + ADP + H(+);beta-D-fructose 2,6-bisphosphate + ADP + H(+) => beta-D-fructose 6-phosphate + ATP;beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate;beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O" "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate;beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate" beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructofuranose 6-phosphate + phosphate 4 out of 5 "Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.; ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate." "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 2,6-bisphosphate;beta-D-fructose 2,6-bisphosphate + H2O <=> D-fructose 6-phosphate + phosphate" YES Fructose and mannose metabolism pathway from kegg "H459;NA" Fructose and mannose metabolism fructose 2,6-bisphosphate biosynthesis "Fructose and mannose metabolism;path:map00051;NA" cytoplasm cytoplasm cytoplasm -602 YLR351C "Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" 3.5.-.- Nit protein Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively. {ECO:0000269|PubMed:28373563}. 3.5.1.3 Omega-amidase NIT3 (EC 3.5.1.3) (Nitrilase homolog 2) "NIT3; putative hydrolase" NA nitrilase "Exocytosis of tertiary granule lumen proteins;Exocytosis of tertiary granule lumen proteins;Exocytosis of specific granule lumen proteins;Exocytosis of specific granule lumen proteins" NA NA "a monoamide of a dicarboxylate + H2O => a dicarboxylate + NH4(+);a dicarboxylate + NH4(+) => a monoamide of a dicarboxylate + H2O" "a monocarboxylic acid amide + H2O = a monocarboxylate + NH3;2-oxoglutaramate + H2O = 2-oxoglutarate + NH3;2-oxosuccinamate + H2O = 2-oxosuccinate + NH3;a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH3;glutaramic acid + H2O = glutaric acid + NH3;Monoamide of dicarboxylate + H2O <=> Dicarboxylate + Ammonia;monoamide of a dicarboxylate + H2O = dicarboxylate + ammonium" "a nitrile + 2 H2O = a carboxylate + ammonium;indole-3-acetonitrile + 2 H2O => ammonium + indole-3-acetate" NA NA 4 out of 5 A monoamide of a dicarboxylate + H(2)O = a dicarboxylate + NH(3). {ECO:0000269|PubMed:28373563}. a monoamide of a dicarboxylate + H2O <=> a dicarboxylate + NH4(+) YES urea cycle "h2o[c] + 2-Oxoglutaramate[c] -> nh4[c] + akg[c] from human; subsystem from human" H590 NA NA NA indole-3-acetate biosynthesis V (bacteria and fungi) Neutrophil degranulation "Alanine, aspartate and glutamate metabolism;path:map00250" "cytoplasm;mitochondrion" -604 YLR369W "Mitochondrial hsp70-type molecular chaperone; required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia" Mitochondrial hsp70-type molecular chaperone Has a role in mitochondrial iron homeostasis. Appears to be involved in the processing of the intermediate form of the frataxin homolog YFH1. Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. {ECO:0000269|PubMed:10779357, ECO:0000269|PubMed:11273703, ECO:0000269|PubMed:12756240, ECO:0000269|PubMed:15123690, ECO:0000269|PubMed:15958384, ECO:0000269|PubMed:16431909, ECO:0000269|PubMed:9660806}. Heat shock protein SSQ1, mitochondrial (Stress-seventy subfamily Q protein 1) (mtHSP70 homolog) "SSQ1, SSC2, SSH1; Hsp70 family ATPase SSQ1" chaperone for [Fe-S] cluster biosynthesis "a [chaperone-ADP]-[disordered-form scaffold protein] complex + ATP => an [Fe-S cluster biosynthesis chaperone]-ATP + a [disordered-form [Fe-S] cluster scaffold protein] + ADP;a [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex + an apo-iron-sulfur protein => a [chaperone-ADP]-[disordered-form scaffold protein] complex + an [Fe-S cluster biosynthesis co-chaperone] + an [2Fe-2S] cluster protein + phosphate;a [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + an [Fe-S cluster biosynthesis chaperone]-ATP => a [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex" 5 out of 5 NA "a [chaperone-ADP]-[disordered-form scaffold protein] complex + ATP => an [Fe-S cluster biosynthesis chaperone]-ATP + a [disordered-form [Fe-S] cluster scaffold protein] + ADP;a [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex + an apo-iron-sulfur protein => a [chaperone-ADP]-[disordered-form scaffold protein] complex + an [Fe-S cluster biosynthesis co-chaperone] + an [2Fe-2S] cluster protein + phosphate;a [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + an [Fe-S cluster biosynthesis chaperone]-ATP => a [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex" YES iron-sulfur cluster biosynthesis "Mitochondrial hsp70-type molecular chaperone; pathway from biocyc" RNA degradation iron-sulfur cluster biosynthesis NA mitochondrion mitochondrion mitochondrion -605 YLR393W "Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6" Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase Essential for the assembly of the mitochondrial F1-F0 complex. Mitochondrial ATPase complex subunit ATP10 "ATP10; Atp10p" ATP synthase ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] 3 out of 5 NA ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] YES Oxidative phosphorylation pathway from kegg superpathway of purine nucleotides de novo biosynthesis I // adenosine nucleotides de novo biosynthesis // adenosine ribonucleotides de novo biosynthesis NA mitochondrial membrane "cytoplasm;mitochondrion;mitochondrial membrane" mitochondrial membrane -613 YLR446W "Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene" 2.7.1.1 Putative hexokinase 2.7.1.1 Putative hexokinase YLR446W (EC 2.7.1.1) hexokinase 2.7.1.1 Unknown "D-hexose + ATP => D-hexose 6-phosphate + ADP + H(+);D-hexose 6-phosphate + ADP + H(+) => D-hexose + ATP" "ATP + H2O = ADP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;ATP + D-hexose = ADP + D-hexose 6-phosphate;ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate;ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate;ATP + D-allose = ADP + D-allose 6-phosphate;ATP + D-arabinose = ADP + D-arabinose 5-phosphate;ATP + D-fructose = ADP + D-fructose 6-phosphate;ATP + D-mannose = ADP + D-mannose 6-phosphate;ITP + D-glucose = IDP + D-glucose 6-phosphate;2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate;dATP + D-fructose = dADP + D-fructose 6-phosphate;ITP + D-fructose = IDP + D-fructose 6-phosphate;ITP + D-mannose = IDP + D-mannose 6-phosphate;dATP + D-mannose = dADP + D-mannose 6-phosphate;ATP + beta-D-glucose = ADP + beta-D-glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate;ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ITP + D-Glucosamine <=> IDP + D-Glucosamine 6-phosphate;dATP + D-Glucosamine <=> dADP + D-Glucosamine 6-phosphate;ITP + D-Hexose <=> IDP + D-Hexose 6-phosphate;dATP + D-Hexose <=> dADP + D-Hexose 6-phosphate;ATP + D-Sorbitol <=> ADP + Sorbitol 6-phosphate;ITP + D-Sorbitol <=> IDP + Sorbitol 6-phosphate;dATP + D-Sorbitol <=> dADP + Sorbitol 6-phosphate;ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ATP + hexose = ADP + hexose 6-phosphate" "D-hexose + ATP => D-hexose 6-phosphate + ADP + H(+);D-hexose 6-phosphate + ADP + H(+) => D-hexose + ATP" "ATP + H2O = ADP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;ATP + D-hexose = ADP + D-hexose 6-phosphate;ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate;ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate;ATP + D-allose = ADP + D-allose 6-phosphate;ATP + D-arabinose = ADP + D-arabinose 5-phosphate;ATP + D-fructose = ADP + D-fructose 6-phosphate;ATP + D-mannose = ADP + D-mannose 6-phosphate;ITP + D-glucose = IDP + D-glucose 6-phosphate;2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate;dATP + D-fructose = dADP + D-fructose 6-phosphate;ITP + D-fructose = IDP + D-fructose 6-phosphate;ITP + D-mannose = IDP + D-mannose 6-phosphate;dATP + D-mannose = dADP + D-mannose 6-phosphate;ATP + beta-D-glucose = ADP + beta-D-glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate;ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ITP + D-Glucosamine <=> IDP + D-Glucosamine 6-phosphate;dATP + D-Glucosamine <=> dADP + D-Glucosamine 6-phosphate;ITP + D-Hexose <=> IDP + D-Hexose 6-phosphate;dATP + D-Hexose <=> dADP + D-Hexose 6-phosphate;ATP + D-Sorbitol <=> ADP + Sorbitol 6-phosphate;ITP + D-Sorbitol <=> IDP + Sorbitol 6-phosphate;dATP + D-Sorbitol <=> dADP + Sorbitol 6-phosphate;ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ATP + hexose = ADP + hexose 6-phosphate" "a D-hexose + ATP = D-hexose 6-phosphate + ADP + H+;D-glucopyranose + ATP => D-glucopyranose 6-phosphate + ADP + H+" "ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate;ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ATP + D-Mannose <=> ADP + D-Mannose 6-phosphate;ATP + beta-D-Glucose <=> ADP + beta-D-Glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate;ATP + D-Glucosamine <=> ADP + D-Glucosamine 6-phosphate;ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate" 2 out of 5 ATP + D-hexose = ADP + D-hexose 6-phosphate. "ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate;ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ATP + D-Mannose <=> ADP + D-Mannose 6-phosphate;ATP + beta-D-Glucose <=> ADP + beta-D-Glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate;ATP + D-Glucosamine <=> ADP + D-Glucosamine 6-phosphate;ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate" YES Glycolysis / Gluconeogenesis pathway from kegg "E155;E166;E388;H329;H1171" "Glycolysis / Gluconeogenesis;Fructose and mannose metabolism;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism" chitin biosynthesis // sucrose degradation III (sucrose invertase) // glycolysis III (from glucose) // trehalose degradation II (trehalase) // glucose-6-phosphate biosynthesis "Glycolysis / Gluconeogenesis;path:map00010;Fructose and mannose metabolism;path:map00051;Galactose metabolism;path:map00052;Starch and sucrose metabolism;path:map00500;Amino sugar and nucleotide sugar metabolism;path:map00520;Streptomycin biosynthesis;path:map00521;Neomycin, kanamycin and gentamicin biosynthesis;path:map00524;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" cytoplasm -621 YML019W "Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p" 2.4.99.18 Subunit of the oligosaccharyltransferase complex of the ER lumen Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Can participate in redox reactions and is able to catalyze dithiol-disulfide exchange reactions with other proteins, albeit with relatively low efficiency. May form transient disulfide bonds with nascent polypeptides in the endoplasmic reticulum and thereby promote efficient glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal oligosaccharyl transferase activity. {ECO:0000269|PubMed:19549845}. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6 (Oligosaccharyl transferase subunit OST6) (EC 2.4.99.18) (Oligosaccharyl transferase 37 kDa subunit) (OTase 37 kDa subunit) "OST6; dolichyl-diphosphooligosaccharide--protein glycotransferase" NA oligosaccharyl transferase complex OST6 subunit NA "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA NA 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps NA "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -630 YML082W "Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; not an essential gene; YML082W has a paralog, STR2, that arose from the whole genome duplication" 2.5.1.48 Putative protein predicted to have carbon-sulfur lyase activity Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity). {ECO:0000250}. 2.5.1.48 Putative cystathionine gamma-synthase YML082W (EC 2.5.1.48) (O-succinylhomoserine (thiol)-lyase) putative cystathionine gamma-synthase 2.5.1.48 "putative cystathionine γ-synthase YML082W" "O-succinyl-L-homoserine + L-cysteine => L-cystathionine + H(+) + succinate;L-cystathionine + H(+) + succinate => O-succinyl-L-homoserine + L-cysteine" "O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate;O-succinyl-L-homoserine + H2O = succinate + 2-oxobutyrate + NH3;O-succinyl-L-homoserine + H2S = L-homocysteine + succinate;O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate;O-acetyl-L-homoserine + L-cysteine = L-cystathionine + acetate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate;O-succinyl-L-homoserine + L-cysteine = O-acetyl-L-homocysteine + L-cysteine;O-succinyl-L-homoserine + L-selenocysteine = selenocystathionine + succinate" "O-succinyl-L-homoserine + L-cysteine => L-cystathionine + H(+) + succinate;L-cystathionine + H(+) + succinate => O-succinyl-L-homoserine + L-cysteine" "O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate;O-succinyl-L-homoserine + H2O = succinate + 2-oxobutyrate + NH3;O-succinyl-L-homoserine + H2S = L-homocysteine + succinate;O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate;O-acetyl-L-homoserine + L-cysteine = L-cystathionine + acetate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate;O-succinyl-L-homoserine + L-cysteine = O-acetyl-L-homocysteine + L-cysteine;O-succinyl-L-homoserine + L-selenocysteine = selenocystathionine + succinate" "L-cysteine + O-succinyl-L-homoserine => succinate + L-cystathionine + H+;O-succinyl-L-homoserine + H2O => 2-oxobutanoate + succinate + ammonium + H+" "O-Succinyl-L-homoserine + H2O <=> 2-Oxobutanoate + Succinate + Ammonia;O-Succinyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Succinate;Cystathionine + Succinate <=> O-Succinyl-L-homoserine + L-Cysteine;O-Acetyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Acetate;O-Succinyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Succinate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate" 3 out of 5 O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate. "L-cysteine + O-succinyl-L-homoserine => succinate + L-cystathionine + H+;O-succinyl-L-homoserine + H2O => 2-oxobutanoate + succinate + ammonium + H+" YES Cysteine and methionine metabolism pathway from kegg E470 "PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1." "Cysteine and methionine metabolism;Selenocompound metabolism;Sulfur metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Biosynthesis of amino acids" superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) // cysteine biosynthesis IV (fungi) // homocysteine and cysteine interconversion "Cysteine and methionine metabolism;path:map00270;Selenocompound metabolism;path:map00450;Sulfur metabolism;path:map00920;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Biosynthesis of antibiotics;path:map01130" "nucleus;cytoplasm" -634 YML125C "Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication" 1.6.2.2 Putative cytochrome b5 reductase, localized to the plasma membrane NADH-dependent cytochrome b5 reductase that reduces coenzyme Q6 at the plasma membrane and mediates lifespan extension by calorie restriction by shifting fermentative to respiratory metabolism, probably through modulating the NAD(+)/NADH ratio. {ECO:0000269|PubMed:16943325, ECO:0000269|PubMed:19239415}. 1.6.2.2 Plasma membrane-associated coenzyme Q6 reductase PGA3 (EC 1.6.2.2) (Processing of GAS1 and ALP protein 3) "PGA3, NQR1; cytochrome-b5 reductase" 1.6.2.2 Processing of Gas1p and ALP CYB5Rs reduce MetHb to Hb "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ CYB5Rs reduce MetHb to Hb 5 out of 5 NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5. {ECO:0000269|PubMed:19239415}. NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ YES Amino sugar and nucleotide sugar metabolism pathway from kegg H588 Amino sugar and nucleotide sugar metabolism Erythrocytes take up carbon dioxide and release oxygen "Amino sugar and nucleotide sugar metabolism;path:map00520" "cell envelope;endoplasmic reticulum membrane" "endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" "cell envelope;endoplasmic reticulum membrane" -643 YMR084W "Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1" 2.6.1.16 Putative protein of unknown function Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins). {ECO:0000250}. 2.6.1.16 Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing] (GFAT) (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (Hexosephosphate aminotransferase) putative glutamine--fructose-6-phosphate transaminase Unknown "D-fructofuranose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate;D-glucosamine 6-phosphate + L-glutamate => D-fructofuranose 6-phosphate + L-glutamine" L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate "D-fructofuranose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate;D-glucosamine 6-phosphate + L-glutamate => D-fructofuranose 6-phosphate + L-glutamine" L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate 3 out of 5 L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. L-glutamine + D-fructose 6-phosphate <=> L-glutamate + D-glucosamine 6-phosphate YES UDP-N-acetyl-alpha-D-glucosamine biosynthesis pathway from uniprot "E417;H276" "PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1." "Alanine, aspartate and glutamate metabolism;path:map00250;Amino sugar and nucleotide sugar metabolism;path:map00520;Metabolic pathways;path:map01100;Biosynthesis of antibiotics;path:map01130" -644 YMR087W "Putative ADP-ribose-1''-monophosphatase; converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain" 3.1.3.84 Putative ADP-ribose-1''-monophosphatase Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. + phosphate. 3.1.3.84 Probable ADP-ribose 1''-phosphate phosphatase YML087W (EC 3.1.3.84) putative ADP-ribose 1''-phosphate phosphatase YMR087W "ADP-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate;ADP-D-ribose + phosphate => ADP-D-ribose 1''-phosphate + H2O" ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate "ADP-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate;ADP-D-ribose + phosphate => ADP-D-ribose 1''-phosphate + H2O" ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate 4 out of 5 ADP-D-ribose 1''-phosphate + H(2)O = ADP-D-ribose + phosphate. ADP-D-ribose 1''-phosphate + H2O <=> ADP-D-ribose + phosphate YES other NA -645 YMR099C "Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS" 5.1.3.15 Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase) Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P). {ECO:0000269|PubMed:16857670}. 5.1.3.15 Glucose-6-phosphate 1-epimerase (EC 5.1.3.15) (D-hexose-6-phosphate mutarotase) glucose-6-phosphate 1-epimerase 5.1.3.15 D-glucose 6-phosphate 1-epimerase "alpha-D-glucose 6-phosphate => beta-D-glucose 6-phosphate;beta-D-glucose 6-phosphate => alpha-D-glucose 6-phosphate" alpha-D-Glucose 6-phosphate = beta-D-glucose 6-phosphate "alpha-D-glucose 6-phosphate => beta-D-glucose 6-phosphate;beta-D-glucose 6-phosphate => alpha-D-glucose 6-phosphate" alpha-D-Glucose 6-phosphate = beta-D-glucose 6-phosphate "alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate;alpha-D-glucose 6-phosphate <=> beta-D-glucose 6-phosphate;alpha-D-mannopyranose 6-phosphate <=> beta-D-mannopyranose 6-phosphate" alpha-D-Glucose 6-phosphate <=> beta-D-Glucose 6-phosphate 4 out of 5 Alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate. {ECO:0000269|PubMed:16857670}. alpha-D-Glucose 6-phosphate <=> beta-D-Glucose 6-phosphate YES Glycolysis / Gluconeogenesis pathway from kegg "Glycolysis / Gluconeogenesis;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics" UDP-glucose biosynthesis "Glycolysis / Gluconeogenesis;path:map00010;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" "nucleus;cytoplasm" -648 YMR110C "Dehydrogenase involved in ubiquinone and sphingolipid metabolism; oxidizes 4-hydroxybenzaldehyde into 4-hydroxybenzoic acid in ubiquinone biosynthesis; converts hexadecenal to hexadecenoic acid in sphingosine 1-phosphate breakdown pathway; located in the mitochondrial outer membrane and also in lipid particles; human homolog ALDH3A2, a fatty aldehyde dehydrogenase (FALDH) mutated in neurocutaneous disorder Sjogren-Larsson syndrome, can complement yeast hfd1 mutant" 1.2.1.3 Dehydrogenase involved in ubiquinone and sphingolipid metabolism Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. {ECO:0000269|PubMed:22633490}. 1.2.1.3 Fatty aldehyde dehydrogenase HFD1 (EC 1.2.1.3) "HFD1; hexadecenal dehydrogenase" 1.2.1.3 Homolog of Fatty aldehyde Dehydrogenase "ALDH3A2-2 oxidizes pristanal to pristanate;ALDH3A2-1 oxidises HD2NAL to PALM;ALD3A1 oxidises 4HPCP to CXPA;ALDH3B1 oxidises HXAL to PALM;Exocytosis of secretory granule membrane proteins;Exocytosis of secretory granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;ALDH3B2 oxidises HXAL to PALM" "an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH;a carboxylate + 2 H(+) + NADH => an aldehyde + H2O + NAD(+);acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH;acetate + 2 H(+) + NADH => acetaldehyde + H2O + NAD(+)" "succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+;4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + H+;(S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+;2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+;an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+;4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH + 2 H+;4-guanidinobutanal + NAD+ + H2O = 4-guanidinobutanoate + NADH + H+;salicylaldehyde + NAD+ + H2O = salicylate + NADH + 2 H+;benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+;Aldehyde + NAD+ + H2O <=> Carboxylate + NADH + H+;glycolaldehyde + NAD+ + H2O = glycolate + NADH + H+;retinal + NAD+ + H2O = retinoate + NADH + H+;phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+;a long-chain aldehyde + NAD+ + H2O = a long-chain carboxylate + NADH + H+;betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+;(2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+;geranial + H2O + NAD+ = geranate + NADH + H+;D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + 2 H+;3-aminopropanal + NAD+ + H2O = 3-aminopropanoate + NADH + H+;propionaldehyde + NAD+ + H2O = propionate + NADH + H+;acetaldehyde + NAD+ + H2O = acetate + NADH + H+;2-oxoglutaric semialdehyde + NAD+ + H2O = 2-oxoglutarate + NADH;D-lactaldehyde + NAD+ + H2O = D-lactate + NADH + H+;p-nitrobenzaldehyde + NAD+ + H2O = p-nitrobenzoate + NADH;octanal + NAD+ + H2O = octanoate + NADH + H+;decanal + NAD+ + H2O = decanoate + NADH;dodecanal + NAD+ + H2O = dodecanoate + NADH;monochloroacetaldehyde + NAD+ + H2O = monochloroacetate + NADH;3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O = 3,4-dihydroxyphenylacetate + NADH + H+;N-acetyl-4-aminobutyraldehyde + NAD+ + H2O = N-acetyl-4-aminobutyrate + NADH;p-methylbenzaldehyde + NAD+ + H2O = p-methylbenzoate + NADH;m-methylbenzaldehyde + NAD+ + H2O = m-methylbenzoate + NADH;indole-3-acetaldehyde + NAD+ + H2O = indole-3-acetate + NADH + H+;3,4-dihydroxymandelic aldehyde + NAD+ + H2O = 3,4-dihydroxymandelate + NADH;5-hydroxyindol acetaldehyde + NAD+ + H2O = 5-hydroxyindol acetate + NADH;acetaldehyde + NADP+ + H2O = acetate + NADPH + H+;propanal + beta-NADP+ + H2O = propionate + beta-NADPH + H+;perillaldehyde + NAD+ + H2O = perillic acid + NADH;octadecanal + NAD+ + H2O = octadecanoic acid + NADH;(S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+;phytenal + NAD+ + H2O = phytenate + NADH + H+;4-aminobutyraldehyde + NADP+ + H2O = 4-aminobutanoate + NADPH;syringaldehyde + NAD+ + H2O = syringic acid + NADH;3-hydroxypropionaldehyde + NAD+ + H2O = 3-hydroxypropanoate + NADH + 2 H+;glyceryl trinitrate + NADH + H+ = 1,3-glyceryl dinitrate + nitrite + NAD+;phosphonoacetaldehyde + NAD+ + H2O = phosphonoacetate + NADH + H+;formaldehyde + NAD+ + H2O = formate + NADH + H+;3-hydroxybenzaldehyde + NAD+ + H2O = 3-hydroxybenzoate + NADH + H+;4-hydroxyphenyl-3-methoxyglycolaldehyde + NAD+ + H2O = 4-hydroxyphenyl-3-methoxyglycolate + NADH;2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH;3-methoxy-4-hydroxyphenylacetaldehyde + NAD+ + H2O = 3-methoxy-4-hydroxyphenylacetate + NADH + H+;1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH;D-glyceraldehyde + NAD+ + H2O = D-glycerate + NADH + H+;Imidazole-4-acetaldehyde + NAD+ + H2O <=> Imidazole-4-acetate + NADH + H+;2-Propynal + NAD+ + H2O <=> Propynoate + NADH + H+;D-Glucuronolactone + NAD+ + 2 H2O <=> D-Glucarate + NADH + H+;p-carboxybenzaldehyde + NAD+ + H2O = p-carboxybenzoate + NADH;Aldehyde + NAD+ + H2O <=> Fatty acid + NADH + H+;(S)-Methylmalonate semialdehyde + NAD+ + H2O <=> Methylmalonate + NADH + H+;3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al + NAD+ + H2O <=> 3alpha,7alpha-Dihydroxy-5beta-cholestanate + NADH + H+;trans-3-Chloroallyl aldehyde + H2O <=> trans-3-Chloroacrylic acid + 2 H+;cis-3-Chloroallyl aldehyde + H2O <=> cis-3-Chloroacrylic acid + 2 H+;(2E)-hexadecenal + NAD+ + H2O = (2E)-hexadecenoate + NADH + H+;hydroxypyruvaldehyde phosphate + H2O + NAD+ = 3-phospho-hydroxypyruvate + NADH + H+;3-dimethylsulfoniopropionaldehyde + H2O + NAD+ = dimethylsulfoniopropanoate + NADH + H+;2-methyl branched 2,3,4-saturated fatty aldehyde + NAD+ + H2O = 2-methyl branched 2,3,4-saturated fatty acid + NADH + H+;odd numbered straight chain 2,3,4-saturated fatty aldehyde + NAD+ + H2O = odd numbered straight chain 2,3,4-saturated fatty acid + NADH + H+;retinol + NAD+ + H2O = retinoic acid + NADH + H+" "an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH;a carboxylate + 2 H(+) + NADH => an aldehyde + H2O + NAD(+);acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH;acetate + 2 H(+) + NADH => acetaldehyde + H2O + NAD(+)" "succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+;4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + H+;(S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+;2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+;an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+;4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH + 2 H+;4-guanidinobutanal + NAD+ + H2O = 4-guanidinobutanoate + NADH + H+;salicylaldehyde + NAD+ + H2O = salicylate + NADH + 2 H+;benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+;Aldehyde + NAD+ + H2O <=> Carboxylate + NADH + H+;glycolaldehyde + NAD+ + H2O = glycolate + NADH + H+;retinal + NAD+ + H2O = retinoate + NADH + H+;phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+;a long-chain aldehyde + NAD+ + H2O = a long-chain carboxylate + NADH + H+;betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+;(2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+;geranial + H2O + NAD+ = geranate + NADH + H+;D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + 2 H+;3-aminopropanal + NAD+ + H2O = 3-aminopropanoate + NADH + H+;propionaldehyde + NAD+ + H2O = propionate + NADH + H+;acetaldehyde + NAD+ + H2O = acetate + NADH + H+;2-oxoglutaric semialdehyde + NAD+ + H2O = 2-oxoglutarate + NADH;D-lactaldehyde + NAD+ + H2O = D-lactate + NADH + H+;p-nitrobenzaldehyde + NAD+ + H2O = p-nitrobenzoate + NADH;octanal + NAD+ + H2O = octanoate + NADH + H+;decanal + NAD+ + H2O = decanoate + NADH;dodecanal + NAD+ + H2O = dodecanoate + NADH;monochloroacetaldehyde + NAD+ + H2O = monochloroacetate + NADH;3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O = 3,4-dihydroxyphenylacetate + NADH + H+;N-acetyl-4-aminobutyraldehyde + NAD+ + H2O = N-acetyl-4-aminobutyrate + NADH;p-methylbenzaldehyde + NAD+ + H2O = p-methylbenzoate + NADH;m-methylbenzaldehyde + NAD+ + H2O = m-methylbenzoate + NADH;indole-3-acetaldehyde + NAD+ + H2O = indole-3-acetate + NADH + H+;3,4-dihydroxymandelic aldehyde + NAD+ + H2O = 3,4-dihydroxymandelate + NADH;5-hydroxyindol acetaldehyde + NAD+ + H2O = 5-hydroxyindol acetate + NADH;acetaldehyde + NADP+ + H2O = acetate + NADPH + H+;propanal + beta-NADP+ + H2O = propionate + beta-NADPH + H+;perillaldehyde + NAD+ + H2O = perillic acid + NADH;octadecanal + NAD+ + H2O = octadecanoic acid + NADH;(S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+;phytenal + NAD+ + H2O = phytenate + NADH + H+;4-aminobutyraldehyde + NADP+ + H2O = 4-aminobutanoate + NADPH;syringaldehyde + NAD+ + H2O = syringic acid + NADH;3-hydroxypropionaldehyde + NAD+ + H2O = 3-hydroxypropanoate + NADH + 2 H+;glyceryl trinitrate + NADH + H+ = 1,3-glyceryl dinitrate + nitrite + NAD+;phosphonoacetaldehyde + NAD+ + H2O = phosphonoacetate + NADH + H+;formaldehyde + NAD+ + H2O = formate + NADH + H+;3-hydroxybenzaldehyde + NAD+ + H2O = 3-hydroxybenzoate + NADH + H+;4-hydroxyphenyl-3-methoxyglycolaldehyde + NAD+ + H2O = 4-hydroxyphenyl-3-methoxyglycolate + NADH;2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH;3-methoxy-4-hydroxyphenylacetaldehyde + NAD+ + H2O = 3-methoxy-4-hydroxyphenylacetate + NADH + H+;1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH;D-glyceraldehyde + NAD+ + H2O = D-glycerate + NADH + H+;Imidazole-4-acetaldehyde + NAD+ + H2O <=> Imidazole-4-acetate + NADH + H+;2-Propynal + NAD+ + H2O <=> Propynoate + NADH + H+;D-Glucuronolactone + NAD+ + 2 H2O <=> D-Glucarate + NADH + H+;p-carboxybenzaldehyde + NAD+ + H2O = p-carboxybenzoate + NADH;Aldehyde + NAD+ + H2O <=> Fatty acid + NADH + H+;(S)-Methylmalonate semialdehyde + NAD+ + H2O <=> Methylmalonate + NADH + H+;3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al + NAD+ + H2O <=> 3alpha,7alpha-Dihydroxy-5beta-cholestanate + NADH + H+;trans-3-Chloroallyl aldehyde + H2O <=> trans-3-Chloroacrylic acid + 2 H+;cis-3-Chloroallyl aldehyde + H2O <=> cis-3-Chloroacrylic acid + 2 H+;(2E)-hexadecenal + NAD+ + H2O = (2E)-hexadecenoate + NADH + H+;hydroxypyruvaldehyde phosphate + H2O + NAD+ = 3-phospho-hydroxypyruvate + NADH + H+;3-dimethylsulfoniopropionaldehyde + H2O + NAD+ = dimethylsulfoniopropanoate + NADH + H+;2-methyl branched 2,3,4-saturated fatty aldehyde + NAD+ + H2O = 2-methyl branched 2,3,4-saturated fatty acid + NADH + H+;odd numbered straight chain 2,3,4-saturated fatty aldehyde + NAD+ + H2O = odd numbered straight chain 2,3,4-saturated fatty acid + NADH + H+;retinol + NAD+ + H2O = retinoic acid + NADH + H+" "2,5-Dioxopentanoate + NADP+ + H2O <=> 2-Oxoglutarate + NADPH + H+;Aldehyde + NAD+ + H2O <=> Fatty acid + NADH + H+;Acetaldehyde + NAD+ + H2O <=> Acetate + NADH + H+;3-Aminopropanal + NAD+ + H2O <=> beta-Alanine + NADH + H+;D-Glyceraldehyde + NAD+ + H2O <=> D-Glycerate + NADH + H+;4-Aminobutyraldehyde + NADP+ + H2O <=> 4-Aminobutanoate + NADPH + H+;4-Aminobutyraldehyde + NAD+ + H2O <=> 4-Aminobutanoate + NADH + H+;Indole-3-acetaldehyde + NAD+ + H2O <=> Indole-3-acetate + NADH + H+;2-Propynal + NAD+ + H2O <=> Propynoate + NADH + H+;D-Glucuronolactone + NAD+ + 2 H2O <=> D-Glucarate + NADH + H+;4-Trimethylammoniobutanal + NAD+ + H2O <=> 4-Trimethylammoniobutanoate + NADH + H+;(S)-Methylmalonate semialdehyde + NAD+ + H2O <=> Methylmalonate + NADH + H+;Imidazole-4-acetaldehyde + NAD+ + H2O <=> Imidazole-4-acetate + NADH + H+;3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al + NAD+ + H2O <=> 3alpha,7alpha-Dihydroxy-5beta-cholestanate + NADH + H+;5-Hydroxyindoleacetaldehyde + NAD+ + H2O <=> 5-Hydroxyindoleacetate + H+ + NADH;N4-Acetylaminobutanal + NAD+ + H2O <=> 4-Acetamidobutanoate + NADH + H+;trans-3-Chloroallyl aldehyde + H2O <=> trans-3-Chloroacrylic acid + 2 H+;cis-3-Chloroallyl aldehyde + H2O <=> cis-3-Chloroacrylic acid + 2 H+;Chloroacetaldehyde + NAD+ + H2O <=> Chloroacetic acid + NADH + H+;Perillyl aldehyde + H2O + NAD+ <=> Perillic acid + NADH + H+;2-trans,6-trans-Farnesal + NAD+ + H2O <=> Farnesoic acid + NADH + H+" "ALDH3A2-2 oxidizes pristanal to pristanate;ALDH3A2-1 oxidises HD2NAL to PALM;ALDH3B1 oxidises HXAL to PALM;Exocytosis of secretory granule membrane proteins;Exocytosis of specific granule membrane proteins;ALDH3B2 oxidises HXAL to PALM" 5 out of 5 An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH. "2,5-Dioxopentanoate + NADP+ + H2O <=> 2-Oxoglutarate + NADPH + H+;Aldehyde + NAD+ + H2O <=> Fatty acid + NADH + H+;Acetaldehyde + NAD+ + H2O <=> Acetate + NADH + H+;3-Aminopropanal + NAD+ + H2O <=> beta-Alanine + NADH + H+;D-Glyceraldehyde + NAD+ + H2O <=> D-Glycerate + NADH + H+;4-Aminobutyraldehyde + NADP+ + H2O <=> 4-Aminobutanoate + NADPH + H+;4-Aminobutyraldehyde + NAD+ + H2O <=> 4-Aminobutanoate + NADH + H+;Indole-3-acetaldehyde + NAD+ + H2O <=> Indole-3-acetate + NADH + H+;2-Propynal + NAD+ + H2O <=> Propynoate + NADH + H+;D-Glucuronolactone + NAD+ + 2 H2O <=> D-Glucarate + NADH + H+;4-Trimethylammoniobutanal + NAD+ + H2O <=> 4-Trimethylammoniobutanoate + NADH + H+;(S)-Methylmalonate semialdehyde + NAD+ + H2O <=> Methylmalonate + NADH + H+;Imidazole-4-acetaldehyde + NAD+ + H2O <=> Imidazole-4-acetate + NADH + H+;3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al + NAD+ + H2O <=> 3alpha,7alpha-Dihydroxy-5beta-cholestanate + NADH + H+;5-Hydroxyindoleacetaldehyde + NAD+ + H2O <=> 5-Hydroxyindoleacetate + H+ + NADH;N4-Acetylaminobutanal + NAD+ + H2O <=> 4-Acetamidobutanoate + NADH + H+;trans-3-Chloroallyl aldehyde + H2O <=> trans-3-Chloroacrylic acid + 2 H+;cis-3-Chloroallyl aldehyde + H2O <=> cis-3-Chloroacrylic acid + 2 H+;Chloroacetaldehyde + NAD+ + H2O <=> Chloroacetic acid + NADH + H+;Perillyl aldehyde + H2O + NAD+ <=> Perillic acid + NADH + H+;2-trans,6-trans-Farnesal + NAD+ + H2O <=> Farnesoic acid + NADH + H+" YES Sphingolipid metabolism "pathway from reactome; it is changed into Sphingolipid metabolism. Subsystem may be wrong according to kegg database" "E74;E595;H86;H970" "Glycolysis / Gluconeogenesis;Fatty acid degradation;Valine, leucine and isoleucine degradation;Lysine degradation;Arginine and proline metabolism;Histidine metabolism;Tryptophan metabolism;beta-Alanine metabolism;Glycerolipid metabolism;Pyruvate metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics" "Sphingolipid de novo biosynthesis;Phase I - Functionalization of compounds;Alpha-oxidation of phytanate;Neutrophil degranulation" "Glycolysis / Gluconeogenesis;path:map00010;Ascorbate and aldarate metabolism;path:map00053;Fatty acid degradation;path:map00071;Valine, leucine and isoleucine degradation;path:map00280;Lysine degradation;path:map00310;Arginine and proline metabolism;path:map00330;Histidine metabolism;path:map00340;Tryptophan metabolism;path:map00380;beta-Alanine metabolism;path:map00410;Glycerolipid metabolism;path:map00561;Pyruvate metabolism;path:map00620;Chloroalkane and chloroalkene degradation;path:map00625;Limonene and pinene degradation;path:map00903;Insect hormone biosynthesis;path:map00981;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" "mitochondrial membrane;cytoplasm" "mitochondrion;mitochondrial membrane;cytoplasm;endoplasmic reticulum;lipid particle" "mitochondrial membrane;cytoplasm" -653 YMR149W "Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum" 2.4.99.18 Delta subunit of the oligosaccharyl transferase glycoprotein complex Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1 (Oligosaccharyl transferase subunit SWP1) (EC 2.4.99.18) (Oligosaccharyl transferase subunit delta) "SWP1; dolichyl-diphosphooligosaccharide-protein glycotransferase" NA "oligosaccharyl transferase complex δ subunit" NA "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA NA 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps NA "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -655 YMR162C "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). phospholipid + ATP + H2O <=> phospholipid + ADP + phosphate + H+ YES phospholipids transport "transport of phospholipids (Probable); reaction not sure" "E586;H449" NA Golgi "Golgi membrane;endoplasmic reticulum;Golgi" Golgi -658 YMR210W "Monoacylglycerol lipase; palmitoyl monoacylglycerol is the preferred substrate; role in triacylglycerol catabolism; minor role in medium-chain fatty acid ethyl ester biosynthesis; contains an alpha/beta hydrolase domain and a typical lipase motif; has similarity to acyltransferases, Eeb1p and Eht1p, and human ABHD1" 3.1.1.- Monoacylglycerol lipase NA 3.1.1.- Putative esterase YMR210W (EC 3.1.1.-) "MGL2; putative carboxylic ester hydrolase" NA monoacylglycerol lipase ABHD3 hydrolyses LPC(14:0) to 1AGPC NA NA NA NA "1-oleoyl-sn-glycerol + H2O => glycerol + oleate + H+;a 1-monoglyceride + H2O => a fatty acid + glycerol + H+" NA ABHD3 hydrolyses LPC(14:0) to 1AGPC 3 out of 5 NA "1-oleoyl-sn-glycerol + H2O => glycerol + oleate + H+;a 1-monoglyceride + H2O => a fatty acid + glycerol + H+" YES Glycerophospholipid metabolism pathway from biocyc and reactome E371 NA NA NA monoacylglycerol metabolism // triacylglycerol degradation Synthesis of PC NA -666 YMR243C "Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication" Vacuolar membrane zinc transporter Probably responsible for the uptake of zinc and cadmium ions. Zinc/cadmium resistance protein "ZRC1, OSR1; Zn(2+) transporter ZRC1" Zinc Resistance Conferring "ZnT1 mediates the efflux of zinc from the cell;SLC30A8 transports Zn2+ from cytosol to secretory granule;SLC30A10 transports Mn2+ from cytosol to extracellular region" ZnT1 mediates the efflux of zinc from the cell 4 out of 5 NA Zn2+ <=> Zn2+ YES zinc transport Vacuolar membrane zinc transporter "Insulin processing;Metal ion SLC transporters;Zinc efflux and compartmentalization by the SLC30 family" NA mitochondrial membrane "vacuole;mitochondrion;mitochondrial membrane" mitochondrial membrane -668 YMR251W "Omega class glutathione transferase; putative cytosolic localization" 2.5.1.18 Omega class glutathione transferase Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). {ECO:0000269|PubMed:16709151}. 2.5.1.18 Glutathione S-transferase omega-like 3 (EC 2.5.1.18) "GTO3; omega-class glutathione transferase" NA Glutathione Transferase Omega-like NA "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" NA NA NA 3 out of 5 RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:16709151}. RX + glutathione = HX + R-S-glutathione YES Glutathione metabolism "pathway from kegg; reaction from uniprot" "H675;H1101" NA NA NA NA NA "Glutathione metabolism;path:map00480;Metabolism of xenobiotics by cytochrome P450;path:map00980;Drug metabolism - cytochrome P450;path:map00982" cytoplasm cytoplasm cytoplasm -669 YMR274C "Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone" 3.4.22.- Type II CAAX prenyl protease Proteolytically removes the C-terminal three residues of farnesylated proteins, including the a-factor mating pheromone and RAS. {ECO:0000269|PubMed:10825201, ECO:0000269|PubMed:9065405}. 3.4.22.- CAAX prenyl protease 2 (EC 3.4.22.-) (Prenyl protein-specific endoprotease 2) (PPSEP 2) (Ras and A-factor-converting enzyme) (RACE) "RCE1; CAAX prenyl protease" NA Ras and a-factor Converting Enzyme "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1;USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1" NA NA NA NA NA S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide NA 4 out of 5 NA S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide YES Terpenoid backbone biosynthesis pathway from kegg H1123 NA NA "Terpenoid backbone biosynthesis;Biosynthesis of antibiotics" NA Ub-specific processing proteases NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -676 YMR301C "Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; human homolog ABCB7 can complement yeast null mutant" Mitochondrial inner membrane ATP-binding cassette (ABC) transporter Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound. {ECO:0000269|PubMed:10406803, ECO:0000269|PubMed:24604199}. Iron-sulfur clusters transporter ATM1, mitochondrial "ATM1; ATP-binding cassette Fe/S cluster precursor transporter ATM1" ABC Transporter, Mitochondrial "ABCB6 transports porphyrin from cytosol to mitchondrial matrix;4Fe-4S cluster assembles on CFD1:NBP35 scaffold;ABC7, mABC1 and mABC2 mediate heme transport" "ABCB6 transports porphyrin from cytosol to mitchondrial matrix;ABC7, mABC1 and mABC2 mediate heme transport" 5 out of 5 NA porphyrin <=> porphyrin YES porphyrin transport "exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; is porphyrin the precursors of iron-sulfur (Fe/S) clusters ??? porphyrin[c] + ATP + H2O <=> porphyrin[m] + ADP + phosphate + H(+)" ABC transporters "Mitochondrial ABC transporters;Cytosolic iron-sulfur cluster assembly (yeast)" NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -678 YMR306W "Protein involved in spore wall assembly; has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" 2.4.1.34 Protein involved in spore wall assembly Required for spore wall assembly. {ECO:0000269|PubMed:17158736}. 2.4.1.34 1,3-beta-glucan synthase component FKS3 (EC 2.4.1.34) (1,3-beta-D-glucan-UDP glucosyltransferase) (FK506 sensitivity protein 3) "FKS3; putative 1,3-beta-D-glucan synthase" 2.4.1.34 FKS3 "[(1->3)-beta-D-glucosyl]n + UDP-alpha-D-glucose => [(1->3)-beta-D-glucosyl]n+1 + H(+) + UDP;[(1->3)-beta-D-glucosyl]n+1 + H(+) + UDP => [(1->3)-beta-D-glucosyl]n + UDP-alpha-D-glucose" UDP-alpha-D-glucose + [(1->3)-beta-D-glucosyl]n = UDP + [(1->3)-beta-D-glucosyl]n+1 "[(1->3)-beta-D-glucosyl]n + UDP-alpha-D-glucose => [(1->3)-beta-D-glucosyl]n+1 + H(+) + UDP;[(1->3)-beta-D-glucosyl]n+1 + H(+) + UDP => [(1->3)-beta-D-glucosyl]n + UDP-alpha-D-glucose" UDP-alpha-D-glucose + [(1->3)-beta-D-glucosyl]n = UDP + [(1->3)-beta-D-glucosyl]n+1 UDP-alpha-D-glucose + 1,3-beta-D-glucan(n) => 1,3-beta-D-glucan(n+1) + UDP UDP-glucose + 1,3-beta-D-Glucan <=> UDP + 1,3-beta-D-Glucan 4 out of 5 UDP-glucose + ((1->3)-beta-D-glucosyl)(n) = UDP + ((1->3)-beta-D-glucosyl)(n+1). UDP-glucose + ((1=>3)-beta-D-glucosyl)(n) = UDP + ((1=>3)-beta-D-glucosyl)(n+1) YES Starch and sucrose metabolism pathway from kegg "Starch and sucrose metabolism;MAPK signaling pathway - yeast" "1,3-β-D-glucan biosynthesis" "Starch and sucrose metabolism;path:map00500" mitochondrion "mitochondrion;endoplasmic reticulum" mitochondrion -680 YMR322C "Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation" 4.2.1.130 Possible chaperone and cysteine protease Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893). {ECO:0000250|UniProtKB:Q04432, ECO:0000269|PubMed:24706893}. 4.2.1.130 Probable glutathione-independent glyoxalase SNO4 (EC 4.2.1.130) (Glyoxalase 3 homolog 4) (Heat shock protein 34) (SNZ proximal open reading frame 4) "SNO4, HSP34; glutathione-independent methylglyoxalase family protein" SNZ proximal Open reading frame "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O 4 out of 5 (R)-lactate = methylglyoxal + H(2)O. {ECO:0000250|UniProtKB:Q04432}. (R)-lactate <=> methylglyoxal + H2O YES Methylglyoxal Metabolism pathway from e.coli model E513 "Pyruvate metabolism;path:map00620;Microbial metabolism in diverse environments;path:map01120" cytoplasm cytoplasm cytoplasm -681 YMR323W "Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose" 4.2.1.11 Enolase, a phosphopyruvate hydratase 4.2.1.11 Enolase-related protein 3 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) "ERR3; phosphopyruvate hydratase ERR3" 4.2.1.11 phophopyruvate hydratase "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O 3 out of 5 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O. 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O YES Glycolysis / Gluconeogenesis pathway from kegg "E61;H213" "PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5." "Glycolysis / Gluconeogenesis;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids;RNA degradation" gluconeogenesis // glycolysis // glycolysis III (from glucose) "Glycolysis / Gluconeogenesis;path:map00010;Methane metabolism;path:map00680;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" cytoplasm -687 YNL036W "Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress" 4.2.1.1 Carbonic anhydrase Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase. Involved in protection against oxidative damage. Encodes a substrate for the non-classical protein export pathway for proteins that lack a cleavable signal sequence. {ECO:0000269|PubMed:10407265, ECO:0000269|PubMed:15096093, ECO:0000269|PubMed:15813743, ECO:0000269|PubMed:15948716, ECO:0000269|PubMed:18993072}. 4.2.1.1 Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) (Non-classical export protein 3) "NCE103, NCE3; carbonate dehydratase NCE103" 4.2.1.1 NonClassical Export "H(+) + hydrogencarbonate => CO2 + H2O;CO2 + H2O => H(+) + hydrogencarbonate" H2CO3 = CO2 + H2O "H(+) + hydrogencarbonate => CO2 + H2O;CO2 + H2O => H(+) + hydrogencarbonate" H2CO3 = CO2 + H2O "Carbonic acid <=> CO2 + H2O;HCO3- + H+ <=> CO2 + H2O" 5 out of 5 H(2)CO(3) = CO(2) + H(2)O. {ECO:0000269|PubMed:15813743, ECO:0000269|PubMed:18993072}. HCO3- + H+ <=> CO2 + H2O YES other no pathway from database "E22;H325;H1060" Nitrogen metabolism "Nitrogen metabolism;path:map00910" "cytoplasm;nucleus;mitochondrial membrane" "nucleus;cytoplasm;mitochondrion;mitochondrial membrane" "nucleus;mitochondrial membrane;cytoplasm" -688 YNL038W "Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol" 2.4.1.198 Protein involved in the synthesis of GlcNAc-PI Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. {ECO:0000269|PubMed:11746600}. 2.4.1.198 Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15 (GPI-GlcNAc transferase complex subunit GPI5) (GPI-GnT subunit GPI5) (EC 2.4.1.198) (PIGH homolog) "GPI15; phosphatidylinositol N-acetylglucosaminyltransferase GPI15" GlycosylPhosphatidylInositol anchor biosynthesis "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" an L-1-phosphatidyl-inositol + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H+ UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 3 out of 5 UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol. UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H479;H1129" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;path:map00563;Metabolic pathways;path:map01100" None -690 YNL048W "Alpha-1,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER" 2.4.1.131 Alpha-1,2-mannosyltransferase Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. {ECO:0000269|PubMed:11278778, ECO:0000269|PubMed:16878994, ECO:0000269|PubMed:19929855}. 2.4.1.131 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131) (Alpha-1,2-mannosyltransferase ALG11) (Asparagine-linked glycosylation protein 11) (Glycolipid 2-alpha-mannosyltransferase) "ALG11; alpha-1,2-mannosyltransferase ALG11" 2.4.1.131 "DP-Man:Man3GlcNAc2-PP-dolichol α-1,2-mannosyltransferase" Addition of the fourth and fifth mannose to the N-glycan precursor skeleton by Alg11 "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose" "alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP;alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP;GDP-alpha-D-mannose + alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+;2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol;more = more" "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose" "alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP;alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP;GDP-alpha-D-mannose + alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+;2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol;more = more" alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+ "G00005 + GDP-D-mannose <=> G10526 + GDP;G10526 + GDP-D-mannose <=> G00006 + GDP" 5 out of 5 2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994, ECO:0000269|PubMed:19929855}. "G00005 + GDP-D-mannose <=> G10526 + GDP;G10526 + GDP-D-mannose <=> G00006 + GDP" YES N-Glycan biosynthesis pathway from kegg "H246;H1138" lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -696 YNL092W "S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene" 2.1.1.22 S-adenosylmethionine-dependent protein methyltransferase N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). {ECO:0000269|PubMed:26001783}. 2.1.1.22 Carnosine N-methyltransferase (EC 2.1.1.22) S-adenosylmethionine-dependent methyltransferase 2.1.1.22 YNL092W CARNMT1 methylates CARN to Anserine "S-adenosyl-L-methionine + carnosine => S-adenosyl-L-homocysteine + anserine + H(+);S-adenosyl-L-homocysteine + anserine + H(+) => S-adenosyl-L-methionine + carnosine" "S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine;actin peptide H + S-adenosyl-L-methionine = actin peptide H methylated at N1-position of histidine + S-adenosyl-L-homocysteine" "S-adenosyl-L-methionine + carnosine => S-adenosyl-L-homocysteine + anserine + H(+);S-adenosyl-L-homocysteine + anserine + H(+) => S-adenosyl-L-methionine + carnosine" "S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine;actin peptide H + S-adenosyl-L-methionine = actin peptide H methylated at N1-position of histidine + S-adenosyl-L-homocysteine" S-Adenosyl-L-methionine + Carnosine <=> S-Adenosyl-L-homocysteine + beta-Alanyl-N(pi)-methyl-L-histidine CARNMT1 methylates CARN to Anserine 4 out of 5 S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine. {ECO:0000269|PubMed:26001783}. S-adenosyl-L-methionine + carnosine <=> S-adenosyl-L-homocysteine + anserine YES Histidine metabolism pathway from kegg Histidine metabolism Histidine catabolism "Histidine metabolism;path:map00340" -697 YNL094W "Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway" 3.1.3.4 Phosphatidate phosphatase, converts phosphatidate to diacylglycerol Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. May play a role in vesicular trafficking through its PAP activity at cortical actin patches. {ECO:0000269|PubMed:23071111}. 3.1.3.4 Phosphatidate phosphatase APP1 (PAP) (EC 3.1.3.4) (Actin patch protein 1) "APP1; phosphatidate phosphatase APP1" Actin Patch Protein "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate;a 1,2-diacyl-sn-glycerol + phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + H2O;1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-2-acyl-sn-glycerol + phosphate;1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O" "a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate;sphingosine 1-phosphate + H2O = sphingosine + phosphate;dihydro-sphingosine-1-phosphate + H2O = dihydro-sphingosine + phosphate;lysophosphatidate + H2O = monoacylglycerol + phosphate;ceramide 1-phosphate + H2O = ceramide + phosphate;2-Acyl-1-alkyl-sn-glycero-3-phosphate + H2O <=> 1-Alkyl-2-acylglycerol + Orthophosphate;1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + H2O = 1-stearoyl-2-palmitoyl-glycerol + phosphate;1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + H2O = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol + phosphate;2-acyl-1-alkyl-sn-glycerol 3-phosphate + H2O = 2-acyl-1-alkyl-sn-glycerol + phosphate;phosphatidic acid + H2O = 1,2-dioleoyl-sn-glycerol + phosphate" "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate;a 1,2-diacyl-sn-glycerol + phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + H2O;1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-2-acyl-sn-glycerol + phosphate;1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O" "a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate;sphingosine 1-phosphate + H2O = sphingosine + phosphate;dihydro-sphingosine-1-phosphate + H2O = dihydro-sphingosine + phosphate;lysophosphatidate + H2O = monoacylglycerol + phosphate;ceramide 1-phosphate + H2O = ceramide + phosphate;2-Acyl-1-alkyl-sn-glycero-3-phosphate + H2O <=> 1-Alkyl-2-acylglycerol + Orthophosphate;1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + H2O = 1-stearoyl-2-palmitoyl-glycerol + phosphate;1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + H2O = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol + phosphate;2-acyl-1-alkyl-sn-glycerol 3-phosphate + H2O = 2-acyl-1-alkyl-sn-glycerol + phosphate;phosphatidic acid + H2O = 1,2-dioleoyl-sn-glycerol + phosphate" 5 out of 5 A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate. {ECO:0000269|PubMed:23071111}. A 1,2-diacylglycerol 3-phosphate + H2O <=> a 1,2-diacyl-sn-glycerol + phosphate YES "Glycerolipid metabolism;Glycerophospholipid metabolism" pathway from kegg "E688;H488;H791" "Glycerolipid metabolism;path:map00561;Glycerophospholipid metabolism;path:map00564;Ether lipid metabolism;path:map00565;Sphingolipid metabolism;path:map00600;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" cytoplasm cytoplasm cytoplasm -699 YNL102W "Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis" 2.7.7.7 Catalytic subunit of the DNA polymerase I alpha-primase complex Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase. POL1 has a role in promoting telomere replication during interaction with CDC13. {ECO:0000269|PubMed:10898792}. 2.7.7.7 DNA polymerase alpha catalytic subunit A (EC 2.7.7.7) (DNA polymerase I subunit A) (DNA polymerase alpha:primase complex p180 subunit) (DNA polymerase-primase complex p180 subunit) (Pol alpha-primase complex p180 subunit) "POL1, CDC17, CRT5, HPR3; DNA-directed DNA polymerase alpha catalytic subunit POL1" 2.7.7.7 POLymerase "Detection of damage during initiation of DNA synthesis in S-phase;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere;RFC binding displaces Pol Alpha on the C-strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin;RFC binding displaces Pol Alpha;Loading of PCNA - Sliding Clamp Formation;RFC dissociates after sliding clamp formation;Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA synthesis H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication" "Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus "nucleus;mitochondrion" nucleus -702 YNL113W "RNA polymerase subunit AC19; common to RNA polymerases I and III" RNA polymerase subunit AC19 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerases I and III 16 kDa polypeptide) (RPA19) "RPC19; DNA-directed RNA polymerase core subunit RPC19" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;Binding of RRN3 to RNA Polymerase I" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation NA nucleus nucleus nucleus -708 YNL151C RNA polymerase III subunit C31 RNA polymerase III subunit C31 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. C31 is involved in the formation of the initiation complex. DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III 31 kDa polypeptide) (C31) "RPC31, ACP2, RPC8; DNA-directed RNA polymerase III subunit C31" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus -713 YNL191W "Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" Component of glutamine amidotransferase (GATase II) Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. {ECO:0000269|PubMed:17179087}. Probable glutamine amidotransferase DUG3 (Deficient in utilization of glutathione protein 3) (GSH degradosomal complex subunit DUG3) "DUG3; glutamine amidotransferase subunit DUG3" glutamine amidotransferase II glutathione + H2O => L-cysteinyl-glycine + L-glutamate 5 out of 5 NA glutathione + H2O => L-cysteinyl-glycine + L-glutamate YES Glutathione metabolism "pathway from biocyc;. It is changed into Glutathione metabolism" glutathione degradation (DUG pathway) NA cytoplasm cytoplasm cytoplasm -717 YNL219C "Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of both the seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; human homolog ALG9 can complement yeast null mutant; mutation of human homolog causes type 1 congenital disorders of glycosylation" "2.4.1.259;2.4.1.261" Mannosyltransferase, involved in N-linked glycosylation Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. {ECO:0000269|PubMed:15987956}. "2.4.1.259; 2.4.1.261" Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) "ALG9; dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase" "2.4.1.259;2.4.1.261" Dol-PP-GlcNAc2:Man6:Man transferase "Addition of the seventh mannose to the N-glycan precursor by ALG9;Addition of the last mannose to the N-glycan precursor by ALG9" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate;alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate;Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-a-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate;alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate;Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-a-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+;alpha-D-Man-a-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+" "Dolichyl phosphate D-mannose + G10595 <=> Dolichyl phosphate + G10596;Dolichyl phosphate D-mannose + G10597 <=> Dolichyl phosphate + G00007" 5 out of 5 "Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:15987956}.; Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:15987956}." "Dolichyl phosphate D-mannose + G10595 <=> Dolichyl phosphate + G10596;Dolichyl phosphate D-mannose + G10597 <=> Dolichyl phosphate + G00007" YES N-Glycan biosynthesis pathway from kegg "H1141;NA" lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100;NA" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -720 YNL229C "Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase activity and can mutate to acquire GST activity; self-assembly under limited nitrogen conditions creates [URE3] prion and releases catabolite repression" "1.11.1.9;1.8.4.-" Nitrogen catabolite repression transcriptional regulator Plays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation. Is also an atypical glutaredoxin without a catalytical cysteine residue. Has glutathione peroxidase and thiol:disulfide oxidoreductase activities in both native and fibrillar form. Also shows insulin disulfide reductase and dehydroascorbic acid reductase (DHAR) actvites. {ECO:0000269|PubMed:10604478, ECO:0000269|PubMed:10799523, ECO:0000269|PubMed:15371425, ECO:0000269|PubMed:19321443, ECO:0000269|PubMed:1990286, ECO:0000269|PubMed:8755910}. "1.8.4.-; 1.11.1.9" Transcriptional regulator URE2 (Disulfide reductase) (EC 1.8.4.-) (Glutathione peroxidase) (EC 1.11.1.9) "URE2; Ure2p" 2.5.1.18 glutathione S-transferase "2 glutathione + H2O2 => glutathione disulfide + 2 H2O;glutathione disulfide + 2 H2O => 2 glutathione + H2O2" "2 glutathione + H2O2 = glutathione disulfide + 2 H2O;tert-butyl hydroperoxide + 2 GSH = tert-butyl alcohol + GSSG + H2O;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;2 Glutathione + 5(S)-HPETE <=> Glutathione disulfide + 5(S)-HETE + H2O;2 Glutathione + 15(S)-HPETE <=> Glutathione disulfide + (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + H2O;glutathione + ROOH = glutathione disulfide + ROH + H2O;5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O" "2 glutathione + H2O2 => glutathione disulfide + 2 H2O;glutathione disulfide + 2 H2O => 2 glutathione + H2O2" "2 glutathione + H2O2 = glutathione disulfide + 2 H2O;tert-butyl hydroperoxide + 2 GSH = tert-butyl alcohol + GSSG + H2O;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;2 Glutathione + 5(S)-HPETE <=> Glutathione disulfide + 5(S)-HETE + H2O;2 Glutathione + 15(S)-HPETE <=> Glutathione disulfide + (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + H2O;glutathione + ROOH = glutathione disulfide + ROH + H2O;5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O" "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+;glutathione + 4-hydroxy-2-nonenal = 4-hydroxy-2-nonenal-glutathione conjugate;glutathione + RX = a glutathione-toxin conjugate + HX" "RX + Glutathione <=> Halide + R-S-Glutathione;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH" 5 out of 5 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O. {ECO:0000269|PubMed:19321443}. 2 glutathione + H2O2 <=> glutathione disulfide + 2 H2O YES Glutathione metabolism pathway from kegg "NA;NA" Glutathione metabolism "NA;NA" cytoplasm cytoplasm cytoplasm -723 YNL248C "RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p" RNA polymerase I subunit A49 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. The heterodimer formed by RPA34 and RPA49 stimulates transcript elongation by Pol I. Subunit RPA49 can bind both single-stranded and double-stranded DNA. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:20797630, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerase I subunit RPA49 (A49) (DNA-directed RNA polymerase I 49 kDa polypeptide) "RPA49; DNA-directed RNA polymerase I subunit RPA49" RNA Polymerase A Binding of RRN3 to RNA Polymerase I a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation NA nucleus nucleus nucleus -724 YNL262W "Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p" 2.7.7.7 Catalytic subunit of DNA polymerase (II) epsilon DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. {ECO:0000269|PubMed:12124389}. 2.7.7.7 DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) "POL2, DUN2; DNA polymerase epsilon catalytic subunit" 2.7.7.7 POLymerase "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;DNA polymerase epsilon binds at the origin" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair" "Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus -725 YNL274C "Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" 1.1.1.26 Glyoxylate reductase Reversibly reduces glyoxylate to glycolate. {ECO:0000269|PubMed:17173333}. 1.1.1.26 Glyoxylate reductase 1 (EC 1.1.1.26) "GOR1; glyoxylate reductase" 1.1.1.26 glyoxylate reductase 1 glyoxylate + NADPH + H+ => glycolate + NADP+ "glycolate + NAD(+) => glyoxylate + H(+) + NADH;glyoxylate + H(+) + NADH => glycolate + NAD(+)" "glycolate + NAD+ = glyoxylate + NADH + H+;D-glycerate + NAD+ = hydroxypyruvate + NADH + H+;glycolate + NADP+ = glyoxylate + NADPH + H+" "glycolate + NAD(+) => glyoxylate + H(+) + NADH;glyoxylate + H(+) + NADH => glycolate + NAD(+)" "glycolate + NAD+ = glyoxylate + NADH + H+;D-glycerate + NAD+ = hydroxypyruvate + NADH + H+;glycolate + NADP+ = glyoxylate + NADPH + H+" glycolate + NAD+ = glyoxylate + NADH + H+ "Glycolate + NAD+ <=> Glyoxylate + NADH + H+;D-Glycerate + NAD+ <=> Hydroxypyruvate + NADH + H+" 5 out of 5 Glycolate + NAD(+) = glyoxylate + NADH. glycolate + NAD+ <=> glyoxylate + NADH + H+ YES Glyoxylate and dicarboxylate metabolism pathway from kegg "E305;E351;E582" "Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Biosynthesis of secondary metabolites" Glyoxylate metabolism and glycine degradation "Glyoxylate and dicarboxylate metabolism;path:map00630;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120" "cytoplasm;nucleus;mitochondrion" "nucleus;cytoplasm;mitochondrion" "mitochondrion;nucleus;cytoplasm" -726 YNL275W "Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1" Boron efflux transporter of the plasma membrane Functions in boric acid/borate export across the plasma membrane, and thereby protects yeast cells from boron toxicity. Involved in the trafficking of proteins to the vacuole. {ECO:0000269|PubMed:11401825, ECO:0000269|PubMed:16565073, ECO:0000269|PubMed:16923078, ECO:0000269|PubMed:17166224, ECO:0000269|PubMed:17459946}. Boron transporter 1 "BOR1; Bor1p" BORon transporter "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-;Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;Na+-driven Cl-/HCO3- exchanger transport;Na+-driven Cl-/HCO3- exchanger transport;SLC4A4 cotransports Na+ with 3HCO3-" "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-;Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;Na+-driven Cl-/HCO3- exchanger transport;Na+-driven Cl-/HCO3- exchanger transport;SLC4A4 cotransports Na+ with 3HCO3-" 4 out of 5 NA Br- <=> Br- YES Boron transport Boron efflux transporter of the plasma membrane "Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Bicarbonate transporters" NA "cell envelope;vacuolar membrane" "vacuole;vacuolar membrane;cell envelope" "cell envelope;vacuolar membrane" -729 YNL315C "Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo" Molecular chaperone Essential for the assembly of the mitochondrial F1-F0 complex. May interact with the alpha and/or beta subunits of F1-ATPase. Protein ATP11, mitochondrial "ATP11; Atp11p" ATP synthase ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] 3 out of 5 NA ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] YES Oxidative phosphorylation pathway from kegg superpathway of purine nucleotides de novo biosynthesis I // adenosine nucleotides de novo biosynthesis // adenosine ribonucleotides de novo biosynthesis NA mitochondrion mitochondrion mitochondrion -732 YNL331C "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" Putative aryl-alcohol dehydrogenase 1.1.1.- Putative aryl-alcohol dehydrogenase AAD14 (EC 1.1.1.-) "AAD14; putative aryl-alcohol dehydrogenase" aryl-alcohol dehydrogenase "3-chlorobenzyl alcohol + NAD+ = 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ = 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ = 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ = p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ = 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ = an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ = benzaldehyde + NADH + H+" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism "pathway from E.coli model; reaction from biocyc" "E646;E743;H1286" NA -733 YNL332W "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" Protein involved in synthesis of the thiamine precursor HMP Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. {ECO:0000250|UniProtKB:P43534}. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI12 (HMP-P synthase) (Hydroxymethylpyrimidine phosphate synthase) (Thiamine biosynthesis protein 12) (Thiamine pyrimidine synthase) "THI12; 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" MONOMER3O-9140 [an HMP-P synthase]-L-histidine + pyridoxal 5'-phosphate => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + an HMP-P synthase Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine 3 out of 5 NA Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine YES Thiamine metabolism pathway from kegg thiamine biosynthesis "PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000305|PubMed:12777485}." "Thiamine metabolism;Metabolic pathways" superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis NA -734 YNL333W "Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p" 4.3.3.6 Member of a stationary phase-induced gene family Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. {ECO:0000250|UniProtKB:Q03148}. 4.3.3.6 Probable pyridoxal 5'-phosphate synthase subunit SNZ2 (PLP synthase subunit SNZ2) (EC 4.3.3.6) (PDX1 homolog 2) (Pdx1.2) "SNZ2; pyridoxine biosynthesis protein SNZ2" 4.3.3.6 SNooZe "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O 3 out of 5 D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate. {ECO:0000250|UniProtKB:Q03148}. D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O YES Vitamin B6 metabolism pathway from kegg "PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis." Vitamin B6 metabolism "Vitamin B6 metabolism;path:map00750" -735 YNL334C "Protein of unknown function; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin" "3.5.1.2;4.3.3.6" Protein of unknown function Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform. {ECO:0000250|UniProtKB:Q03144, ECO:0000269|PubMed:12271461}. "4.3.3.6; 3.5.1.2" Probable pyridoxal 5'-phosphate synthase subunit SNO2 (EC 4.3.3.6) (PDX2 homolog 2) (Pdx2.2) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) "SNO2; putative pyridoxal 5'-phosphate synthase" 4.3.3.6 SNZ proximal Open reading frame "L-glutamine + H2O => L-glutamate + NH4(+);L-glutamate + NH4(+) => L-glutamine + H2O;aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-glutamine + H2O = D-glutamate + NH3;a monocarboxylic acid amide + H2O = a monocarboxylate + NH3;L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine;L-glutamine + H2O => L-glutamate + NH4(+);L-glutamate + NH4(+) => L-glutamine + H2O" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+;L-glutamine + H2O = L-glutamate + NH3;D-glutamine + H2O = D-glutamate + NH3;a monocarboxylic acid amide + H2O = a monocarboxylate + NH3" D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O 4 out of 5 "D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate. {ECO:0000250|UniProtKB:Q03144}.; L-glutamine + H(2)O = L-glutamate + NH(3). {ECO:0000250|UniProtKB:Q03144}." "D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O; L-glutamine + H(2)O = L-glutamate + NH(3)" YES Vitamin B6 metabolism pathway from kegg "NA;NA" "PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. {ECO:0000250|UniProtKB:Q03144}." Vitamin B6 metabolism "Vitamin B6 metabolism;path:map00750;NA" cytoplasm -736 YNL335W "Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI2 and Ddi2p" 4.2.1.69 Cyanamide hydratase that detoxifies cyanamide Cyanamide hydratase involved in the detoxification and/or utilization of cyanamide, a toxic nitrile compound distributed widely in the environment. {ECO:0000269|PubMed:25847245}. 4.2.1.69 Cyanamide hydratase DDI3 (CAH) (EC 4.2.1.69) (DNA damage-inducible protein 3) "DDI3; cyanamide hydratase" 4.2.1.69 DNA Damage Inducible "urea => cyanamide + H2O;cyanamide + H2O => urea" urea = cyanamide + H2O "urea => cyanamide + H2O;cyanamide + H2O => urea" urea = cyanamide + H2O Urea <=> Cyanamide + H2O 4 out of 5 Urea = cyanamide + H(2)O. {ECO:0000269|PubMed:25847245}. Urea <=> Cyanamide + H2O YES Atrazine degradation pathway from kegg Atrazine degradation "Atrazine degradation;path:map00791;Microbial metabolism in diverse environments;path:map01120" -738 YNR003C "RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex" RNA polymerase III subunit C34 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in recruitment of Pol III to the preinitiation complex. Involved in the configuration of an initiation-competent form of RNA polymerase. {ECO:0000269|PubMed:9312031}. DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (C34) (DNA-directed RNA polymerase III 36 kDa polypeptide) "RPC34; DNA-directed RNA polymerase III subunit C34" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus "nucleus;cytoplasm;mitochondrion" nucleus -741 YNR027W "Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)" 2.7.1.35 Putative pyridoxal kinase Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (By similarity). Important for bud site selection. {ECO:0000250, ECO:0000269|PubMed:11452010}. 2.7.1.35 Putative pyridoxal kinase BUD17 (EC 2.7.1.35) (Bud site selection protein 17) "BUD17; putative pyridoxal kinase BUD17" 2.7.1.35 BUD site selection "Exocytosis of secretory granule lumen proteins;Exocytosis of secretory granule lumen proteins;Exocytosis of specific granule lumen proteins;Exocytosis of specific granule lumen proteins;2xPDXK:2xZn2+ phosphorylates PXA;2xPDKX:2xZn2+ phosphorylates PDX;2xPDXK:2xZn2+ phosphorylates PXL" "ATP + pyridoxal => ADP + H(+) + pyridoxal 5'-phosphate;ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal;ATP + pyridoxamine => ADP + H(+) + pyridoxamine 5'-phosphate;ADP + H(+) + pyridoxamine 5'-phosphate => ATP + pyridoxamine;ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate;ADP + H(+) + pyridoxine 5'-phosphate => ATP + pyridoxine" "ATP + pyridoxine = ADP + pyridoxine 5'-phosphate;ATP + pyridoxamine = ADP + pyridoxamine 5'-phosphate;ATP + pyridoxal = ADP + pyridoxal 5'-phosphate" "ATP + pyridoxal => ADP + H(+) + pyridoxal 5'-phosphate;ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal;ATP + pyridoxamine => ADP + H(+) + pyridoxamine 5'-phosphate;ADP + H(+) + pyridoxamine 5'-phosphate => ATP + pyridoxamine;ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate;ADP + H(+) + pyridoxine 5'-phosphate => ATP + pyridoxine" "ATP + pyridoxine = ADP + pyridoxine 5'-phosphate;ATP + pyridoxamine = ADP + pyridoxamine 5'-phosphate;ATP + pyridoxal = ADP + pyridoxal 5'-phosphate" "ATP + Pyridoxal <=> ADP + Pyridoxal phosphate;ATP + Pyridoxine <=> ADP + Pyridoxine phosphate;ATP + Pyridoxamine <=> ADP + Pyridoxamine phosphate" "2xPDXK:2xZn2+ phosphorylates PXA;2xPDKX:2xZn2+ phosphorylates PDX;2xPDXK:2xZn2+ phosphorylates PXL" 4 out of 5 ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. ATP + pyridoxal <=> ADP + pyridoxal 5'-phosphate YES Vitamin B6 metabolism pathway from kegg E125 "Vitamin B6 metabolism;Metabolic pathways" "Neutrophil degranulation;Vitamins B6 activation to pyridoxal phosphate" "Vitamin B6 metabolism;path:map00750;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -743 YNR030W "Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant" 2.4.1.260 Alpha-1,6-mannosyltransferase localized to the ER Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. {ECO:0000269|PubMed:10336995, ECO:0000269|PubMed:15987956}. 2.4.1.260 Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Extracellular mutant protein 39) (Mannosyltransferase ALG12) "ALG12, ECM39; dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase" 2.4.1.260 "dolichyl-P-Man:Man7GlcNAc2-PP-dolichol α-1,6-mannosyltransferase" Addition of the eighth mannose to the N-glycan precursor by ALG12 "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-a-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-a-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-mannosyl phosphate => alpha-D-Man-a-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+ Dolichyl phosphate D-mannose + G10596 <=> Dolichyl phosphate + G10597 4 out of 5 Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:15987956}. Dolichyl phosphate D-mannose + G10596 <=> Dolichyl phosphate + G10597 YES N-Glycan biosynthesis pathway from kegg H1142 lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -751 YNR060W "Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" 1.16.1.9 Ferric reductase Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to dihydroxamate rhodotorulic acid. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. {ECO:0000269|PubMed:11120744}. 1.16.1.9 Ferric reductase transmembrane component 4 (EC 1.16.1.9) (Ferric-chelate reductase 4) "FRE4; ferric-chelate reductase" Ferric REductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" 2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+ 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope cell envelope cell envelope -752 YNR073C "Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication" Mannitol dehydrogenase 1.1.1.- Mannitol dehydrogenase YNR073C (EC 1.1.1.-) "MAN2; putative mannitol dehydrogenase" 1.1.1.67 YNR073C Mannitol + NAD+ <=> D-Fructose + NADH + H+ 2 out of 5 NA Mannitol + NAD+ <=> D-Fructose + NADH + H+ YES Fructose and mannose metabolism pathway from kegg "E646;E743;H1286" Fructose and mannose metabolism NA -754 YOL005C "RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit" RNA polymerase II subunit B12.5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft. Seems to be involved transcript termination. {ECO:0000269|PubMed:16537912}. DNA-directed RNA polymerase II subunit RPB11 (RNA polymerase II subunit B11) (B13.6) (DNA-directed RNA polymerase II 13.6 kDa polypeptide) "RPB11; DNA-directed RNA polymerase II core subunit RPB11" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus -763 YOL075C Putative ABC transporter Putative ABC transporter Uncharacterized ABC transporter ATP-binding protein/permease YOL075C hypothetical protein YOL075C "ABCG5:ABCG8 transports sterols from cytosol to extracellular region;ABCG5:ABCG8 transports sterols from cytosol to extracellular region" "ABCG5:ABCG8 transports sterols from cytosol to extracellular region;ABCG5:ABCG8 transports sterols from cytosol to extracellular region" 3 out of 5 NA sterols <=> sterols YES sterols transport transports sterols from cytosol to extracellular ABC transporters in lipid homeostasis NA "vacuole;cell envelope" -766 YOL092W "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication" Putative vacuolar membrane transporter for cationic amino acids May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. {ECO:0000269|PubMed:23169667}. Probable vacuolar amino acid transporter YPQ1 (PQ-loop repeat-containing protein 1) "YPQ1; cationic amino acid transporter" Yeast PQ-loop protein PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 4 out of 5 NA "L-Arg <=> L-Arg; L-His <=> L-His; L-Lys <=> L-Lys" YES "L-Arg transport (from lysosomal lumen to cytosol); L-His transport (from lysosomal lumen to cytosol); L-Lys transport (from lysosomal lumen to cytosol)" cationic amino acids transport Miscellaneous transport and binding events NA vacuolar membrane "vacuole;cytoplasm;vacuolar membrane;endoplasmic reticulum" vacuolar membrane -777 YOL152W "Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels" 1.16.1.9 Putative ferric reductase with similarity to Fre2p Cell surface metalloreductase. May be involved in copper homeostasis. {ECO:0000269|PubMed:17553781, ECO:0000269|PubMed:17681937}. 1.16.1.9 Ferric/cupric reductase transmembrane component 7 (EC 1.16.1.9) (Ferric-chelate reductase 7) "FRE7; putative ferric-chelate reductase" Ferric REductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" 2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+ 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope cell envelope cell envelope -778 YOL157C "Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose" 3.2.1.10 Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase) Alpha-glucosidase with specificity for isomaltase, methyl-alpha-glucoside, and palatinose. {ECO:0000269|PubMed:20562106}. 3.2.1.10 Oligo-1,6-glucosidase IMA2 (EC 3.2.1.10) (Alpha-glucosidase) (Isomaltase 2) "IMA2; oligo-1,6-glucosidase IMA2" 3.2.1.10 IsoMAltase SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu "isomaltose + h2O = 2 D-glucose;Starch + H2O <=> Amylose + alpha-D-Glucose;nigerose + H2O = 2 D-glucose;alpha,alpha-trehalose + H2O = 2 beta-D-glucose;sucrose + H2O = D-fructose + alpha-D-glucose;dextrin + H2O = dextrin + beta-D-glucose;oligosaccharide + H2O = monosaccharide" "isomaltose + h2O = 2 D-glucose;Starch + H2O <=> Amylose + alpha-D-Glucose;nigerose + H2O = 2 D-glucose;alpha,alpha-trehalose + H2O = 2 beta-D-glucose;sucrose + H2O = D-fructose + alpha-D-glucose;dextrin + H2O = dextrin + beta-D-glucose;oligosaccharide + H2O = monosaccharide" "(1,4-alpha-D-glucosyl)(n) + H2O => (1,4-alpha-D-glucosyl)(n-1) + D-glucopyranose;maltose + H2O => 2 D-glucopyranose;maltotriose + H2O => maltose + D-glucopyranose" "Sucrose + H2O <=> D-Fructose + D-Glucose;Isomaltose + H2O <=> alpha-D-Glucose + D-Glucose;Dextrin + H2O <=> D-Glucose + Dextrin;Starch(n+1) + H2O <=> alpha-D-Glucose + Starch(n)" SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu 3 out of 5 Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. "Sucrose + H2O <=> D-Fructose + D-Glucose;Isomaltose + H2O <=> alpha-D-Glucose + D-Glucose;Dextrin + H2O <=> D-Glucose + Dextrin;Starch(n+1) + H2O <=> alpha-D-Glucose + Starch(n)" YES Starch and sucrose metabolism "Alpha-glucosidase with specificity for isomaltase, methyl-alpha-glucoside, and palatinose; pathway from kegg" "H432;H1196" "Galactose metabolism;Starch and sucrose metabolism;Metabolic pathways" Amino acid transport across the plasma membrane "Galactose metabolism;path:map00052;Starch and sucrose metabolism;path:map00500;Metabolic pathways;path:map01100" -779 YOL165C "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD15 has a paralog, AAD3, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" Putative aryl-alcohol dehydrogenase Putative aryl-alcohol dehydrogenase. {ECO:0000250}. 1.1.1.- Putative aryl-alcohol dehydrogenase AAD15 (EC 1.1.1.-) "AAD15; putative aryl-alcohol dehydrogenase" aryl-alcohol dehydrogenase "3-chlorobenzyl alcohol + NAD+ = 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ = 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ = 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ = p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ = 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ = an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ = benzaldehyde + NADH + H+" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism "pathway from E.coli model; reaction from biocyc" "E646;E743;H1286" NA -780 YOR002W "Alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in human ortholog ALG6 causes carbohydrate-deficient glycoprotein syndrome type-Ic; wild-type human ortholog ALG6 can partially complement yeast alg6 mutant" 2.4.1.267 Alpha 1,3 glucosyltransferase Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. {ECO:0000269|PubMed:8877369}. 2.4.1.267 Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase) "ALG6; dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase" 2.4.1.267 (mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol glucosyltransferase Addition of the first glucose to the N-glycan precursor by ALG6 "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+ Dolichyl D-glucosyl phosphate + G00007 <=> Dolichyl phosphate + G10598 5 out of 5 Dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:8877369}. Dolichyl D-glucosyl phosphate + G00007 <=> Dolichyl phosphate + G10598 YES N-Glycan biosynthesis pathway from kegg H1145 lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -787 YOR067C "Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; human homolog ALG8 can complement yeast null mutant" 2.4.1.265 Glucosyl transferase Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol. {ECO:0000269|PubMed:3536907}. 2.4.1.265 Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase) "ALG8, YOR29-18; dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase" 2.4.1.265 (glucosyl)-(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol glucosyltransferase Addition of a second glucose to the N-glycan precursor by ALG8 "alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+ Dolichyl D-glucosyl phosphate + G10598 <=> Dolichyl phosphate + G10599 4 out of 5 Dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:3536907}. Dolichyl D-glucosyl phosphate + G10598 <=> Dolichyl phosphate + G10599 YES N-Glycan biosynthesis pathway from kegg lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -788 YOR085W "Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins" 2.4.99.18 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 (EC 2.4.99.18) (Oligosaccharyl transferase 34 kDa subunit) (Oligosaccharyl transferase subunit OST3) (Oligosaccharyl transferase subunit gamma) "OST3; dolichyl-diphosphooligosaccharide--protein glycotransferase OST3" NA "oligosaccharyl transferase complex γ subunit" "TUSC3 transports Mg2+ from extracellular region to cytosol;MAGT1 transports Mg2+ from extracellular region to cytosol;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA "TUSC3 transports Mg2+ from extracellular region to cytosol;MAGT1 transports Mg2+ from extracellular region to cytosol;Exocytosis of azurophil granule membrane proteins" 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps "Miscellaneous transport and binding events;Neutrophil degranulation" "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -790 YOR103C "Epsilon subunit of the oligosaccharyltransferase complex; located in the ER lumen; catalyzes asparagine-linked glycosylation of newly synthesized proteins" 2.4.99.18 Epsilon subunit of the oligosaccharyltransferase complex Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2 (Oligosaccharyl transferase subunit OST2) (EC 2.4.99.18) (Oligosaccharyl transferase 16 kDa subunit) (Oligosaccharyl transferase subunit epsilon) "OST2; dolichyl-diphosphooligosaccharide-protein glycotransferase" NA "oligosaccharyl transferase complex ε subunit" NA "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA NA 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps NA "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -792 YOR116C "RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21" 2.7.7.6 RNA polymerase III largest subunit C160 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). {ECO:0000250}. 2.7.7.6 DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (RNA polymerase III subunit C160) "RPO31, RPC1, RPC160; DNA-directed RNA polymerase III core subunit RPO31" 2.7.7.6 RNA POlymerase "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus -795 YOR149C "Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure" 2.4.1.- Alpha 1,2-mannosyltransferase Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi. Involved in plasmid maintenance with SMP2. {ECO:0000269|PubMed:11356840}. 2.4.1.- GPI mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) "SMP3, LAS2, SAP2; glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase" alpha 1,2 mannosyltransferase mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI Dolichyl phosphate D-mannose + G00149 <=> Dolichyl phosphate + G00140 4 out of 5 NA Dolichyl phosphate D-mannose + G00149 <=> Dolichyl phosphate + G00140 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H815;H837;H838;H839" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis." Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Synthesis of glycosylphosphatidylinositol (GPI) NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -796 YOR151C "RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit" 2.7.7.6 RNA polymerase II second largest subunit B150 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerases II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcription cycle, Pol II, general transcription factors and the Mediator complex assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcription elongation in which it moves on the template as the transcript elongates. Pol II appears to oscillate between inactive and active conformations at each step of nucleotide addition. Pol II is composed of mobile elements that move relative to each other. The core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. The clamp element (portions of RPB1, RPB2 and RPB3) is connected to the core through a set of flexible switches and moves to open and close the cleft. The cleft is surrounded by jaws: an upper jaw formed by portions of RBP1, RPB2 and RPB9, and a lower jaw. The jaws are thought to grab the incoming DNA template. The fork loop 1 (RPB2) interacts with the RNA-DNA hybrid, possibly stabilizing it. 2.7.7.6 DNA-directed RNA polymerase II subunit RPB2 (RNA polymerase II subunit 2) (EC 2.7.7.6) (B150) (DNA-directed RNA polymerase II 140 kDa polypeptide) "RPB2, RPB150, RPO22, SIT2, SOH2; DNA-directed RNA polymerase II core subunit RPB2" 2.7.7.6 RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus "nucleus;mitochondrion;cytoplasm" nucleus -798 YOR161C "Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport" Protein of unknown function Probably involved in transport through the plasma membrane. {ECO:0000250}. Protein PNS1 (pH nine-sensitive protein 1) "PNS1; Pns1p" pH Nine Sensitive "Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;SLC44A1 transports Cho from cytosol to mitochondrial matrix;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" "Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;SLC44A1 transports Cho from cytosol to mitochondrial matrix;Exocytosis of specific granule membrane proteins" 2 out of 5 NA choline <=> choline YES choline transport choline transporter. Choline[e] <=> choline[c] "Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Choline catabolism;Neutrophil degranulation" NA cell envelope cell envelope cell envelope -799 YOR196C "Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase" 2.8.1.8 Protein involved in biosynthesis of the coenzyme lipoic acid Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000305|PubMed:19570983, ECO:0000305|PubMed:8349643}. 2.8.1.8 Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase) "LIP5; putative lipoate synthase" 2.8.1.8 lipoyl synthase LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH "2 (sulfur carrier)-SH + 2 S-adenosyl-L-methionine + [protein]-N(6)-octanoyl-L-lysine + 2 reduced [2Fe-2S]-[ferredoxin] => 2 (sulfur carrier)-H + 2 5'-deoxyadenosine + [protein]-(R)-N(6)-lipoyl-L-lysine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin];2 (sulfur carrier)-H + 2 5'-deoxyadenosine + [protein]-(R)-N(6)-lipoyl-L-lysine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 (sulfur carrier)-SH + 2 S-adenosyl-L-methionine + [protein]-N(6)-octanoyl-L-lysine + 2 reduced [2Fe-2S]-[ferredoxin]" "Protein N6-(octanoyl)lysine + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine;Octanoyl-[acp] + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine;[glycine-cleavage complex H protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[lipoyl-carrier protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [lipoyl-carrier protein]-N6-lipoyl-L-lysine + 5'-deoxyadenosine + L-methionine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] cluster = protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] cluster;protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosine;protein N6-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = protein N6-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin" "2 (sulfur carrier)-SH + 2 S-adenosyl-L-methionine + [protein]-N(6)-octanoyl-L-lysine + 2 reduced [2Fe-2S]-[ferredoxin] => 2 (sulfur carrier)-H + 2 5'-deoxyadenosine + [protein]-(R)-N(6)-lipoyl-L-lysine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin];2 (sulfur carrier)-H + 2 5'-deoxyadenosine + [protein]-(R)-N(6)-lipoyl-L-lysine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 (sulfur carrier)-SH + 2 S-adenosyl-L-methionine + [protein]-N(6)-octanoyl-L-lysine + 2 reduced [2Fe-2S]-[ferredoxin]" "Protein N6-(octanoyl)lysine + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine;Octanoyl-[acp] + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine;[glycine-cleavage complex H protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[lipoyl-carrier protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [lipoyl-carrier protein]-N6-lipoyl-L-lysine + 5'-deoxyadenosine + L-methionine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] cluster = protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] cluster;protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosine;protein N6-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = protein N6-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin" "a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier] + 2 a reduced [2Fe-2S] ferredoxin => a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 L-methionine + 2 5'-deoxyadenosine + 2 an unsulfurated [sulfur carrier] + 2 an oxidized [2Fe-2S] ferredoxin;a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier] + 2 a reduced [2Fe-2S] ferredoxin => a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + 2 L-methionine + 2 5'-deoxyadenosine + 2 an unsulfurated [sulfur carrier] + 2 an oxidized [2Fe-2S] ferredoxin;a [lipoyl-carrier protein] N6-octanoyl-L-lysine + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier] + 2 a reduced [2Fe-2S] ferredoxin => a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + 2 5'-deoxyadenosine + 2 L-methionine + 2 an unsulfurated [sulfur carrier] + 2 an oxidized [2Fe-2S] ferredoxin;a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier] + 2 a reduced [2Fe-2S] ferredoxin => a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 L-methionine + 2 5'-deoxyadenosine + 2 an unsulfurated [sulfur carrier] + 2 an oxidized [2Fe-2S] ferredoxin" "Protein N6-(octanoyl)lysine + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine;Octanoyl-[acp] + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine" NA 3 out of 5 Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin. {ECO:0000255|HAMAP-Rule:MF_03123}. "Protein N6-(octanoyl)lysine + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine;Octanoyl-[acp] + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine" YES Lipoic acid metabolism pathway from kegg "H1034;H1036" NA "PATHWAY: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03123}." "Lipoic acid metabolism;Metabolic pathways" lipoate biosynthesis and incorporation (glycine cleavage system) // superpathway of lipoate biosynthesis and incorporation (PDH, KGDH, GCV) // lipoate biosynthesis and incorporation (pyruvate dehydrogenase and oxoglutarate dehydrogenase) // lipoate biosynthesis and incorporation I Glyoxylate metabolism and glycine degradation "Lipoic acid metabolism;path:map00785;Metabolic pathways;path:map01100" mitochondrion mitochondrion mitochondrion -801 YOR207C "Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs" 2.7.7.6 Second-largest subunit of RNA polymerase III DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}. 2.7.7.6 DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 130 kDa polypeptide) "RET1, PDS2, RPC128, RPC2; DNA-directed RNA polymerase III core subunit RET1" 2.7.7.6 Reduced Efficiency of Termination "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus -803 YOR210W "RNA polymerase subunit ABC10-beta; common to RNA polymerases I, II, and III" RNA polymerase subunit ABC10-beta DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (ABC10-beta) (ABC8) (DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide) "RPB10; DNA-directed RNA polymerase core subunit RPB10" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Binding of RRN3 to RNA Polymerase I;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase I Transcription Initiation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus -805 YOR224C "RNA polymerase subunit ABC14.5; common to RNA polymerases I, II, and III" RNA polymerase subunit ABC14.5 DNA-dependent RNA polymerases catalyze the transcription. of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (ABC14.4) (ABC14.5) (DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide) "RPB8; DNA-directed RNA polymerase core subunit RPB8" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Binding of RRN3 to RNA Polymerase I;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase I Transcription Initiation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus -806 YOR226C "Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant" Mitochondrial protein required for iron-sulfur protein synthesis Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2. In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH. Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1. ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (By similarity). ISU2 is the minor isoform in yeast and is not detectable in cells grown to stationary phase (PubMed:10588895). {ECO:0000250|UniProtKB:Q03020, ECO:0000269|PubMed:10588895}. Iron sulfur cluster assembly protein 2, mitochondrial (Iron sulfur cluster scaffold protein 2) "ISU2, NUA2; putative iron-binding protein ISU2" ISU2 [Fe-s} cluster scaffold protein monomer "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster;Frataxin binds iron" an S-sulfanyl-[L-cysteine desulfurase] + a [disordered-form [Fe-S] cluster scaffold protein] => an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex 5 out of 5 NA an S-sulfanyl-[L-cysteine desulfurase] + a [disordered-form [Fe-S] cluster scaffold protein] => an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex YES iron-sulfur cluster biosynthesis pathway from biocyc "PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis. {ECO:0000269|PubMed:10588895, ECO:0000269|PubMed:15143178}." iron-sulfur cluster biosynthesis Mitochondrial iron-sulfur cluster biogenesis NA mitochondrion mitochondrion mitochondrion -812 YOR251C "Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized" 2.8.1.1 Rhodanese domain sulfur transferase Required for formation of the 2-thio group of the 5-methoxycarbonylmethyl-2-thiouridine modified base in some tRNAs. {ECO:0000269|PubMed:18755837}. 2.8.1.1 Thiosulfate sulfurtransferase TUM1 (EC 2.8.1.1) (Thiouridine modification protein 1) "TUM1; thiosulfate sulfurtransferase" "2.8.1.1;2.8.1.2" TUM1 sulfurtransferase "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate;2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate" "thiosulfate + cyanide = sulfite + thiocyanate + H+;sulfurated [sulfur carrier] + hydrogen cyanide = unsulfurated [sulfur carrier] + thiocyanate + H+" "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate;2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate" "thiosulfate + cyanide = sulfite + thiocyanate + H+;sulfurated [sulfur carrier] + hydrogen cyanide = unsulfurated [sulfur carrier] + thiocyanate + H+" "an [L-cysteine desulfurase] L-cysteine persulfide + a [TUM1 protein]-L-cysteine => an [L-cysteine desulfurase]-L-cysteine + a [TUM1]-S-sulfanylcysteine;thiosulfate + hydrogen cyanide => sulfite + thiocyanate + 2 H+" "Thiosulfate + Cyanide ion <=> Sulfite + Thiocyanate;Mercaptopyruvate + Sulfite <=> Thiosulfate + Pyruvate;Hydrogen cyanide + Mercaptopyruvate <=> Thiocyanate + Pyruvate" 4 out of 5 Thiosulfate + cyanide = sulfite + thiocyanate. hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate YES Sulfur metabolism "pathway from kegg; reaction from rhea" "E405;H677;H1177" "Cysteine and methionine metabolism;Sulfur metabolism;Metabolic pathways;Sulfur relay system" tRNA-uridine 2-thiolation (yeast mitochondria) // thiosulfate disproportionation III (rhodanese) "Sulfur metabolism;path:map00920;Microbial metabolism in diverse environments;path:map01120" "mitochondrion;cytoplasm" "cytoplasm;mitochondrion" "mitochondrion;cytoplasm" -818 YOR283W "Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene" 3.1.3.- Phosphatase with a broad substrate specificity Metal-independent phosphatase active against a broad range of phosphorylated substrates including nucleoside tri- and diphosphates, phosphorylated organic acids, and amino acids. Shows no activity against phytic acid, phosphorylated carbohydrates, and nucleoside monophosphates. {ECO:0000269|PubMed:19753119, ECO:0000269|PubMed:20427268}. 3.1.3.- Broad-specificity phosphatase YOR283W (EC 3.1.3.-) phosphoglycerate mutase 5.4.2.12 YOR283W TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate 2-phospho-D-glycerate <=> 3-phospho-D-glycerate 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate 3 out of 5 NA 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate YES Glycolysis / Gluconeogenesis pathway from kegg "E88;E587;H1052" "Glycolysis / Gluconeogenesis;Glycine, serine and threonine metabolism;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids" gluconeogenesis // glycolysis TP53 Regulates Metabolic Genes NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -819 YOR285W "Thiosulfate sulfurtransferase; contains a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress; similar to the human TSTD gene" 2.8.1.1 Thiosulfate sulfurtransferase Thiosulfate:glutathione sulfurtransferase (TST) required to produce glutathione persulfide (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). {ECO:0000269|PubMed:24981631}. 2.8.1.- Thiosulfate:glutathione sulfurtransferase (TST) (EC 2.8.1.-) (Rhodanese-like protein 1) "RDL1; thiosulfate sulfurtransferase RDL1" RhoDanese-Like protein Thiosulfate can transfer its sulfur atom to glutathione "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate;2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate" "thiosulfate + cyanide = sulfite + thiocyanate + H+;sulfurated [sulfur carrier] + hydrogen cyanide = unsulfurated [sulfur carrier] + thiocyanate + H+" thiosulfate + hydrogen cyanide => sulfite + thiocyanate + 2 H+ Thiosulfate can transfer its sulfur atom to glutathione 5 out of 5 NA hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate YES Sulfur metabolism "pathway from kegg; reaction from rhea" H1233 thiosulfate disproportionation III (rhodanese) Sulfide oxidation to sulfate NA mitochondrion "mitochondrion;mitochondrial membrane;endoplasmic reticulum" mitochondrion -820 YOR286W "Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss" 2.8.1.1 Protein with rhodanese activity Thiosulfate sulfurtransferase which catalyzes the transfer of sulfane sulfur from thiosulfate to cyanide. {ECO:0000269|PubMed:19864628}. 2.8.1.1 Thiosulfate sulfurtransferase RDL2, mitochondrial (EC 2.8.1.1) (Altered inheritance of mitochondria protein 42) (Found in mitochondrial proteome protein 31) (Rhodanese-like protein 2) "RDL2, AIM42; thiosulfate sulfurtransferase RDL2" "thiosulfate—thiol sulfurtransferase" Thiosulfate can transfer its sulfur atom to glutathione "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate;2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate" "thiosulfate + cyanide = sulfite + thiocyanate + H+;sulfurated [sulfur carrier] + hydrogen cyanide = unsulfurated [sulfur carrier] + thiocyanate + H+" "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate;2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate" "thiosulfate + cyanide = sulfite + thiocyanate + H+;sulfurated [sulfur carrier] + hydrogen cyanide = unsulfurated [sulfur carrier] + thiocyanate + H+" thiosulfate + 2 a thiol = sulfite + hydrogen sulfide + a disulfide + H+ Thiosulfate can transfer its sulfur atom to glutathione 4 out of 5 Thiosulfate + cyanide = sulfite + thiocyanate. hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate YES Sulfur metabolism "pathway from kegg; reaction from rhea" "E405;H677;H1177" Sulfide oxidation to sulfate "Sulfur metabolism;path:map00920;Microbial metabolism in diverse environments;path:map01120" mitochondrion mitochondrion mitochondrion -823 YOR316C "Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication" Vacuolar transporter that mediates zinc transport into the vacuole Probably responsible for the uptake of cobalt ions. It appears to act in a dosage-dependent manner to counteract the adverse effects of cobalt ions on cells. It may participate in the regulation of cobalt levels under normal physiological conditions and may be important in the supply of metal that is required for metalloenzyme or cofactor synthesis. It reduces the toxicity of cobalt and rhodium ions. Other components responsible for cobalt transport exist. Cobalt uptake protein COT1 "COT1; metal cation transporter COT1" CObalt Toxicity "ZnT1 mediates the efflux of zinc from the cell;SLC30A8 transports Zn2+ from cytosol to secretory granule;SLC30A10 transports Mn2+ from cytosol to extracellular region" ZnT1 mediates the efflux of zinc from the cell 5 out of 5 NA Zn2+ <=> Zn2+ YES zinc transport Zn2+ transport "Insulin processing;Metal ion SLC transporters;Zinc efflux and compartmentalization by the SLC30 family" NA mitochondrial membrane "vacuole;mitochondrion;mitochondrial membrane" mitochondrial membrane -824 YOR330C "Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occur more frequently in some lab strains; human ortholog POLG complements yeast mip1 mutant; mutations in human POLG associated with Alpers-Huttenlocher syndrome (AHS), progressive external ophthalmoplegia (PEO), parkinsonism, other mitochondrial diseases" 2.7.7.7 Mitochondrial DNA polymerase gamma Involved in the replication of mitochondrial DNA. 2.7.7.7 DNA polymerase gamma (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) "MIP1; DNA-directed DNA polymerase gamma MIP1" 2.7.7.7 MItochondrial DNA Polymerase "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate 4 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication Mitochondrial DNA polymerase gamma H1117 "Metabolic pathways;Mitophagy - yeast" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" mitochondrion mitochondrion mitochondrion -825 YOR334W "Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA" Mitochondrial inner membrane Mg(2+) channel High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix (PubMed:12628916, PubMed:17827224, PubMed:20653776, PubMed:23999289). Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes (PubMed:11544180). {ECO:0000269|PubMed:11544180, ECO:0000269|PubMed:12628916, ECO:0000269|PubMed:17827224, ECO:0000269|PubMed:20653776, ECO:0000269|PubMed:23999289}. Magnesium transporter MRS2, mitochondrial (RNA-splicing protein MRS2) "MRS2; Mrs2p" Mitochondrial RNA Splicing MRS2 transports Mg2+ from cytosol to mitochondrial matrix MRS2 transports Mg2+ from cytosol to mitochondrial matrix 5 out of 5 NA Mg2+ <=> Mg2+ YES magnesium transport Mg2+ transport Miscellaneous transport and binding events NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -827 YOR340C RNA polymerase I subunit A43 RNA polymerase I subunit A43 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. Through its association with RRN3 is involved in recruitment of Pol I to rDNA promoters. In vitro, the A13-A43 subcomplex binds single-stranded RNA. {ECO:0000269|PubMed:11032814, ECO:0000269|PubMed:12888498, ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerase I subunit RPA43 (A43) (DNA-directed DNA-dependent RNA polymerase 36 kDa polypeptide) "RPA43; DNA-directed RNA polymerase I subunit RPA43" RNA Polymerase A a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus -828 YOR341W RNA polymerase I largest subunit A190 2.7.7.6 RNA polymerase I largest subunit A190 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. RPA190 and RPA135 both contribute to the polymerase catalytic activity and together form the Pol I active center. In addition, subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA190 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. 2.7.7.6 DNA-directed RNA polymerase I subunit RPA190 (EC 2.7.7.6) (DNA-directed RNA polymerase I 190 kDa polypeptide) (A190) (DNA-directed RNA polymerase I largest subunit) "RPA190, RRN1; DNA-directed RNA polymerase I core subunit RPA190" 2.7.7.6 RNA Polymerase A Binding of RRN3 to RNA Polymerase I "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus -830 YOR356W "Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase" 1.5.5.1 Putative ortholog of human ETF-dH Accepts electrons from ETF and reduces ubiquinone. {ECO:0000250}. 1.5.5.1 Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Changed intracellular redox state protein 2) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase) "CIR2; putative electron-transferring-flavoprotein dehydrogenase" 1.5.5.1 Changed Intracellular Redox state ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 "a ubiquinone + reduced [electron-transfer flavoprotein] => a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein];a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] => a ubiquinone + reduced [electron-transfer flavoprotein]" "reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol;reduced electron-transfer flavoprotein + ubiquinone = oxidized electron-transfer flavoprotein + ubiquinol + H+;ubiquinone + reduced electron-transfer flavoprotein = ubiquinol + oxidized electron-transfer flavoprotein + H+" "a ubiquinone + reduced [electron-transfer flavoprotein] => a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein];a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] => a ubiquinone + reduced [electron-transfer flavoprotein]" "reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol;reduced electron-transfer flavoprotein + ubiquinone = oxidized electron-transfer flavoprotein + ubiquinol + H+;ubiquinone + reduced electron-transfer flavoprotein = ubiquinol + oxidized electron-transfer flavoprotein + H+" a reduced electron-transfer flavoprotein + ubiquinone-6 = an oxidized electron-transfer flavoprotein + ubiquinol-6 + H+ 5 out of 5 Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol. a ubiquinone + reduced [electron-transfer flavoprotein] <=> a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] YES Respiratory electron transport "pathway from reactome; reaction from rhea" "H215;H1270" Respiratory electron transport NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -833 YOR381W "Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" 1.16.1.9 Ferric reductase Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to di- and trihydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. {ECO:0000269|PubMed:11120744}. 1.16.1.9 Ferric reductase transmembrane component 3 (EC 1.16.1.9) (Ferric-chelate reductase 3) "FRE3; ferric-chelate reductase" ferric reductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+;2 an Fe(III)-siderophore + NADPH => 2 Fe2+ + 2 a siderophore + NADP+ + H+;2 ferric (2,3-dihydroxybenzoylserine)3 + NADPH + 9 H+ => 2 Fe2+ + 2 (2,3-dihydroxybenzoylserine)3 + NADP+" 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope "vacuole;cell envelope" cell envelope -834 YOR384W "Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" 1.16.1.9 Putative ferric reductase with similarity to Fre2p Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity). {ECO:0000250}. 1.16.1.9 Ferric reductase transmembrane component 5 (EC 1.16.1.9) (Ferric-chelate reductase 5) "FRE5; putative ferric-chelate reductase" Ferric REductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" 2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+ 4 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope "mitochondrion;cell envelope" cell envelope -836 YOR391C "Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer" "3.2.-.-;4.2.1.130" Possible chaperone and cysteine protease Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893). {ECO:0000250|UniProtKB:Q04432, ECO:0000269|PubMed:24706893}. 4.2.1.130 Probable glutathione-independent glyoxalase HSP33 (EC 4.2.1.130) (Glyoxalase 3 homolog 3) (Heat shock protein 33) "HSP33; glutathione-independent methylglyoxalase family protein" Heat-Shock Protein "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O 4 out of 5 (R)-lactate = methylglyoxal + H(2)O. {ECO:0000250|UniProtKB:Q04432}. (R)-lactate <=> methylglyoxal + H2O YES Methylglyoxal Metabolism pathway from e.coli model E513 "Pyruvate metabolism;path:map00620;Microbial metabolism in diverse environments;path:map01120" cytoplasm cytoplasm cytoplasm -837 YOR393W Putative phosphopyruvate hydratase 4.2.1.11 Putative phosphopyruvate hydratase 4.2.1.11 Enolase-related protein 1 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) "ERR1; phosphopyruvate hydratase ERR1" 4.2.1.11 enolase "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O 3 out of 5 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O. 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O YES Glycolysis / Gluconeogenesis pathway from kegg "E61;H213" "PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5." "Glycolysis / Gluconeogenesis;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids;RNA degradation" gluconeogenesis // glycolysis // glycolysis III (from glucose) "Glycolysis / Gluconeogenesis;path:map00010;Methane metabolism;path:map00680;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" None -839 YPL006W "Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p" Vacuolar membrane protein Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments. {ECO:0000269|PubMed:14970192, ECO:0000269|PubMed:16138904}. Niemann-Pick type C-related protein 1 "NCR1; sphingolipid transporter" Niemann-pick type C Related "NPC1L1 inactivation by ezetimibe;PTCH is internalized;PTCH is internalized;SMURF1/2 dissociates from ub-PTCH1;CHOL translocates from lysosome membrane to ER membrane" CHOL translocates from lysosome membrane to ER membrane 4 out of 5 NA sphingolipid <=> sphingolipid YES sphingolipid transport "sphingolipid transporter; sphingolipid[c] <=> sphingolipid[er]" "Hedgehog 'on' state;Intestinal lipid absorption;LDL clearance" NA vacuolar membrane "vacuole;vacuolar membrane;endoplasmic reticulum" vacuolar membrane -848 YPL060W "Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p" Mitochondrial inner membrane magnesium transporter Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. {ECO:0000269|PubMed:11254124, ECO:0000269|PubMed:17827224, ECO:0000269|PubMed:20653776}. Mitochondrial inner membrane magnesium transporter MFM1 (MRS2 function modulating factor 1) "MFM1, LPE10; Mfm1p" Mrs2 Function Modulating factor MRS2 transports Mg2+ from cytosol to mitochondrial matrix MRS2 transports Mg2+ from cytosol to mitochondrial matrix 4 out of 5 NA Mg2+ <=> Mg2+ YES magnesium transport Mg2+ transport Miscellaneous transport and binding events NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -851 YPL076W "Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol" 2.4.1.198 Protein involved in the synthesis of GlcNAc-PI Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. {ECO:0000269|PubMed:7768896}. 2.4.1.198 Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit (GPI-GlcNAc transferase complex subunit GPI2) (GPI-GnT subunit GPI2) (EC 2.4.1.198) "GPI2, GCR4; phosphatidylinositol N-acetylglucosaminyltransferase" GlycosylPhosphatidylInositol anchor biosynthesis "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" an L-1-phosphatidyl-inositol + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H+ UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 4 out of 5 UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol. UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H479;H1129" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000305|PubMed:7768896}." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;path:map00563;Metabolic pathways;path:map01100" "endoplasmic reticulum;endoplasmic reticulum membrane" -854 YPL088W "Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance" Putative aryl alcohol dehydrogenase Putative aryl-alcohol dehydrogenase. {ECO:0000250}. 1.1.1.- Putative aryl-alcohol dehydrogenase AAD16 (EC 1.1.1.-) aldo-keto reductase superfamily protein YPL088W "AKR dimers reduce AFBDHO to AFBDOH;AKR dimers reduce AFBDHO to AFBDOH;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" "AKR dimers reduce AFBDHO to AFBDOH;AKR dimers reduce AFBDHO to AFBDOH" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism pathway from kegg "E646;E743;H1286" "Aflatoxin activation and detoxification;Neutrophil degranulation" NA -861 YPL132W "Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p" NA Protein required for delivery of copper to Cox1p Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. {ECO:0000250}. NA Cytochrome c oxidase assembly protein COX11, mitochondrial "COX11, LPI13, PSO7; Cox11p" NA Cytochrome c OXidase NA NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 4 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA "Oxidative phosphorylation;Metabolic pathways" aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -862 YPL135W "Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant" Conserved protein of the mitochondrial matrix Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2. In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH. Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1. ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (PubMed:10588895, PubMed:12970193, PubMed:14741370, PubMed:15123690, PubMed:16341089, PubMed:16431909, PubMed:23615440, PubMed:25358379). {ECO:0000269|PubMed:10588895, ECO:0000269|PubMed:12970193, ECO:0000269|PubMed:14741370, ECO:0000269|PubMed:15123690, ECO:0000269|PubMed:16341089, ECO:0000269|PubMed:16431909, ECO:0000269|PubMed:23615440, ECO:0000269|PubMed:25358379}. Iron sulfur cluster assembly protein 1, mitochondrial (Iron sulfur cluster scaffold protein 1) "ISU1, NUA1; iron-binding protein ISU1" ISU1 [Fe-S] cluster scaffold protein monomer "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster;Frataxin binds iron" an S-sulfanyl-[L-cysteine desulfurase] + a [disordered-form [Fe-S] cluster scaffold protein] => an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex 5 out of 5 NA an S-sulfanyl-[L-cysteine desulfurase] + a [disordered-form [Fe-S] cluster scaffold protein] => an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex YES iron-sulfur cluster biosynthesis "Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters; pathway from kegg" "PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis. {ECO:0000269|PubMed:10588895, ECO:0000269|PubMed:15123690, ECO:0000269|PubMed:15143178, ECO:0000269|PubMed:16431909}." iron-sulfur cluster biosynthesis Mitochondrial iron-sulfur cluster biogenesis NA mitochondrion mitochondrion mitochondrion -870 YPL167C "Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev7p, Pol31p and Pol32p" 2.7.7.7 Catalytic subunit of DNA polymerase zeta Nonessential DNA polymerase. Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Translesion synthesis in S.cerevisiae may use a specialized DNA polymerase that is not required for other DNA replicative processes. Has a role in the bypass of abasic (AP) sites. Highly inefficient in incorporating nucleotides opposite the AP site, but efficiently extends from nucleotides, particularly an A, inserted opposite the lesion. {ECO:0000269|PubMed:11316789, ECO:0000269|PubMed:16452144, ECO:0000269|PubMed:2676986, ECO:0000269|PubMed:8658138}. 2.7.7.7 DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3) "REV3, PSO1; Rev3p" 2.7.7.7 REVersionless "POLK incorporates dNMP opposite to damaged DNA base;POLI incorporates dNMP opposite to damaged DNA base" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). {ECO:0000269|PubMed:11316789}. 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA synthesis . Nonessential DNA polymerase H1117 Metabolic pathways "Translesion synthesis by POLK;Translesion synthesis by POLI" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" "mitochondrion;nucleus" "nucleus;mitochondrion" "mitochondrion;nucleus" -871 YPL171C "Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death" 1.6.99.1 Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) Oxidizes beta-NADH, beta-NADPH, and alpha-NADPH. 1.6.99.1 NADPH dehydrogenase 3 (EC 1.6.99.1) (Old yellow enzyme 3) "OYE3, ZRG6; NADPH dehydrogenase" 1.6.99.1 NADPH dehydrogenase "NADPH + H+ + acceptor = NADP+ + reduced acceptor;2-cyclohexen-1-one + NADPH + H+ = cyclohexanone + NADP+" "NADPH + H+ + acceptor = NADP+ + reduced acceptor;2-cyclohexen-1-one + NADPH + H+ = cyclohexanone + NADP+" an oxidized electron acceptor + NADPH + H+ = a reduced electron acceptor + NADP+ Acceptor + NADPH + H+ <=> Reduced acceptor + NADP+ 4 out of 5 NADPH + acceptor = NADP(+) + reduced acceptor. Acceptor + NADPH + H+ <=> Reduced acceptor + NADP+ YES other NA -872 YPL175W "UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins" 2.4.1.198 UDP-glycosyltransferase subunit of the GPI-GnT complex Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. {ECO:0000269|PubMed:10970797, ECO:0000269|PubMed:7768896}. 2.4.1.198 Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit (GPI-GlcNAc transferase complex subunit GPI3) (GPI-GnT subunit GPI3) (EC 2.4.1.198) (GlcNAc-PI synthesis protein) "SPT14, CWH6, GPI3; phosphatidylinositol N-acetylglucosaminyltransferase SPT14" 2.4.1.198 SuPpressor of Ty "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" an L-1-phosphatidyl-inositol + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H+ UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 5 out of 5 UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol. UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H479;H1129" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000305|PubMed:7737116}." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;path:map00563;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane;cytoplasm" endoplasmic reticulum membrane -879 YPL227C "UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant" 2.4.1.117 UDP-glucose:dolichyl-phosphate glucosyltransferase 2.4.1.117 Dolichyl-phosphate beta-glucosyltransferase (DolP-glucosyltransferase) (EC 2.4.1.117) (Asparagine-linked glycosylation protein 5) "ALG5; dolichyl-phosphate beta-glucosyltransferase" 2.4.1.117 UDP-glucose:dolichyl-phosphate glucosyltransferase Synthesis of dolichyl-phosphate-glucose "dolichyl phosphate + UDP-alpha-D-glucose => dolichyl beta-D-glucosyl phosphate + UDP;dolichyl beta-D-glucosyl phosphate + UDP => dolichyl phosphate + UDP-alpha-D-glucose" UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate "dolichyl phosphate + UDP-alpha-D-glucose => dolichyl beta-D-glucosyl phosphate + UDP;dolichyl beta-D-glucosyl phosphate + UDP => dolichyl phosphate + UDP-alpha-D-glucose" UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate a dolichyl phosphate + UDP-alpha-D-glucose => a dolichyl beta-D-glucosyl phosphate + UDP UDP-glucose + Dolichyl phosphate <=> UDP + Dolichyl beta-D-glucosyl phosphate 3 out of 5 UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate. UDP-glucose + Dolichyl phosphate <=> UDP + Dolichyl beta-D-glucosyl phosphate YES N-Glycan biosynthesis pathway from kegg "H569;H1144" dolichyl glucosyl phosphate biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Metabolic pathways" dolichyl glucosyl phosphate biosynthesis // protein N-glycosylation (eukaryotic) initial steps Synthesis of dolichyl-phosphate-glucose "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane -886 YPL280W "Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer" "3.2.-.-;4.2.1.130" Possible chaperone and cysteine protease Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893). {ECO:0000250|UniProtKB:Q04432, ECO:0000269|PubMed:24706893}. 4.2.1.130 Probable glutathione-independent glyoxalase HSP32 (EC 4.2.1.130) (Glyoxalase 3 homolog 2) (Heat shock protein 32) "HSP32; glutathione-independent methylglyoxalase family protein" Heat-Shock Protein "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O 4 out of 5 (R)-lactate = methylglyoxal + H(2)O. {ECO:0000250|UniProtKB:Q04432}. (R)-lactate <=> methylglyoxal + H2O YES Methylglyoxal Metabolism pathway from e.coli model E513 "Pyruvate metabolism;path:map00620;Microbial metabolism in diverse environments;path:map01120" cytoplasm cytoplasm cytoplasm -887 YPL281C "Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant" 4.2.1.11 Enolase, a phosphopyruvate hydratase 4.2.1.11 Enolase-related protein 2 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) "ERR2; phosphopyruvate hydratase ERR2" 4.2.1.11 enolase "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O 3 out of 5 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O. 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O YES Glycolysis / Gluconeogenesis pathway from kegg "E61;H213" "PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5." "Glycolysis / Gluconeogenesis;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids;RNA degradation" gluconeogenesis // glycolysis // glycolysis III (from glucose) "Glycolysis / Gluconeogenesis;path:map00010;Methane metabolism;path:map00680;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" None -889 YPR003C "Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene" Putative sulfate permease Possible sulfate transporter. Putative sulfate transporter YPR003C hypothetical protein YPR003C "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol;SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol;Group 3 - Selective Cl- transport;Group 3 - Selective Cl- transport;SLC26A3,6 exchange Cl- for HCO3-;SLC26A3,6 exchange Cl- for HCO3-;SLC26A4 transports I- from cytosol to extracellular region" "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol;SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol;Group 3 - Selective Cl- transport;Group 3 - Selective Cl- transport;SLC26A3,6 exchange Cl- for HCO3-;SLC26A3,6 exchange Cl- for HCO3-;SLC26A4 transports I- from cytosol to extracellular region" 3 out of 5 NA SO4(2-) <=> SO4(2-) YES sulfate transport Putative sulfate permease "Transport and synthesis of PAPS;Multifunctional anion exchangers" NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" endoplasmic reticulum membrane -890 YPR010C RNA polymerase I second largest subunit A135 2.7.7.6 RNA polymerase I second largest subunit A135 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. RPA190 and RPA135 both contribute to the polymerase catalytic activity and together form the Pol I active center. In addition, subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA190 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. 2.7.7.6 DNA-directed RNA polymerase I subunit RPA135 (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (A135) (DNA-directed RNA polymerase I polypeptide 2) (RNA polymerase I subunit 2) "RPA135, RPA2, RRN2, SRP3; DNA-directed RNA polymerase I core subunit RPA135" 2.7.7.6 RNA Polymerase A Binding of RRN3 to RNA Polymerase I "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus -899 YPR110C "RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes" RNA polymerase subunit AC40 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I (Pol I) and III (Pol III) which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPC40 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft (PubMed:18160037, PubMed:24153182, PubMed:24153184). Plays an important role in targeting retrotransposons Ty integration upstream of pol III-transcribed genes such as tRNA genes, allowing Ty1, Ty2 and Ty4 to proliferate and yet minimizing genetic damage (PubMed:25931562). {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184, ECO:0000269|PubMed:25931562, ECO:0000305|PubMed:10384303}. DNA-directed RNA polymerases I and III subunit RPAC1 (RNA polymerases I and III subunit AC1) (C37) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (AC40) (C40) "RPC40, RPC5; DNA-directed RNA polymerase core subunit RPC40" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;Binding of RRN3 to RNA Polymerase I" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation NA nucleus nucleus nucleus -901 YPR127W "Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" 1.1.1.65 Putative pyridoxine 4-dehydrogenase Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+). {ECO:0000250}. 1.1.1.65 Putative pyridoxal reductase (PL reductase) (PL-red) (EC 1.1.1.65) pyridoxine 4-dehydrogenase 1.1.1.65 pyridoxine 4-dehydrogenase "NADP(+) + pyridoxine => H(+) + NADPH + pyridoxal;H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine" pyridoxine + NADP+ = pyridoxal + NADPH + H+ "NADP(+) + pyridoxine => H(+) + NADPH + pyridoxal;H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine" pyridoxine + NADP+ = pyridoxal + NADPH + H+ pyridoxine + NADP+ <=> pyridoxal + NADPH + H+ Pyridoxine + NADP+ <=> Pyridoxal + NADPH + H+ 3 out of 5 Pyridoxine + NADP(+) = pyridoxal + NADPH. Pyridoxine + NADP+ <=> Pyridoxal + NADPH + H+ YES Vitamin B6 metabolism pathway from kegg "PATHWAY: Cofactor degradation; B6 vitamer degradation; pyridoxal from pyridoxine (dehydrogenase route): step 1/1." "Vitamin B6 metabolism;Metabolic pathways" superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis "Vitamin B6 metabolism;path:map00750;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -903 YPR139C "Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA" 2.3.1.51 Lysophosphatidic acid acyltransferase Acyl-CoA-dependent lysophosphatidic acid acyltransferase with preference for oleoyl-CoA. Involved in triacylglyceride homeostasis and lipid droplet formation. Involved in vacuolar protein sorting. {ECO:0000269|PubMed:12134085, ECO:0000269|PubMed:22090344}. 2.3.1.51 Lysophosphatidic acid:oleoyl-CoA acyltransferase 1 (LPAAT) (Lysophosphatidic acid acyltransferase) (EC 2.3.1.51) (Vacuolar protein sorting-associated protein 66) "LOA1, VPS66; lysophosphatidic acid acyltransferase LOA1" oleoyl-CoA: lysophosphatidate acyltransferase "1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA;a 1,2-diacyl-sn-glycero-3-phosphate + CoA => 1-acyl-sn-glycero-3-phosphate + an acyl-CoA" "acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate;palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate;acyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate;1-oleoyl-sn-glycerol-3-phosphate + oleoyl-CoA = CoA + 1,2-oleoyl-sn-glycerol-3-phosphate;2,3-Dehydroacyl-CoA + 1-Acyl-sn-glycerol 3-phosphate <=> CoA + Phosphatidate;palmitoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];long-chain acyl-[acyl-carrier protein] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl 2-acyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];stearoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-stearoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];oleoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];18-hydroxylinoleoyl-CoA + 1-[18-hydroxyoleyl]-2-lyso-phosphatidate = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + coenzyme A;palmitoleoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-CoA + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];myristoyl-CoA + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + coenzyme A;myristoyl-[acp] + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + holo-[acyl-carrier protein];1-palmitoylglycerol 3-phosphate + myristoyl-CoA = 1-palmitoyl-2-myristoyl phosphatidate + coenzyme A;1-palmitoylglycerol 3-phosphate + myristoyl-[acp] = 1-palmitoyl-2-myristoyl phosphatidate + holo-[acyl-carrier protein];long-chain acyl-CoA + 1-alkyl-sn-glycerol 3-phosphate = 2-acyl-1-alkyl-sn-glycerol 3-phosphate + coenzyme A;2,3,4-saturated fatty acyl-[acp] + 2,3,4-saturated 2-lysophosphatidate = 2,3,4-saturated L-phosphatidate + holo-[acyl-carrier protein];palmitoyl-[acp] + 1-palmitoylglycerol 3-phosphate = dipalmitoyl phosphatidate + holo-[acyl-carrier protein];oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol = CoA + 1,2-dioleoyl-sn-phosphatidylinositol;myristoyl-CoA + 1-myristoyl-sn-glycerol 3-phosphate = CoA + 1,2-dimyristoyl-sn-glycerol 3-phosphate;lauroyl-CoA + 1-lauroyl-sn-glycerol 3-phosphate = CoA + 1,2-dilauroyl-sn-glycerol 3-phosphate;arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate" "1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA;a 1,2-diacyl-sn-glycero-3-phosphate + CoA => 1-acyl-sn-glycero-3-phosphate + an acyl-CoA" "acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate;palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate;acyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate;1-oleoyl-sn-glycerol-3-phosphate + oleoyl-CoA = CoA + 1,2-oleoyl-sn-glycerol-3-phosphate;2,3-Dehydroacyl-CoA + 1-Acyl-sn-glycerol 3-phosphate <=> CoA + Phosphatidate;palmitoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];long-chain acyl-[acyl-carrier protein] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl 2-acyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];stearoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-stearoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];oleoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];18-hydroxylinoleoyl-CoA + 1-[18-hydroxyoleyl]-2-lyso-phosphatidate = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + coenzyme A;palmitoleoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-CoA + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];myristoyl-CoA + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + coenzyme A;myristoyl-[acp] + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + holo-[acyl-carrier protein];1-palmitoylglycerol 3-phosphate + myristoyl-CoA = 1-palmitoyl-2-myristoyl phosphatidate + coenzyme A;1-palmitoylglycerol 3-phosphate + myristoyl-[acp] = 1-palmitoyl-2-myristoyl phosphatidate + holo-[acyl-carrier protein];long-chain acyl-CoA + 1-alkyl-sn-glycerol 3-phosphate = 2-acyl-1-alkyl-sn-glycerol 3-phosphate + coenzyme A;2,3,4-saturated fatty acyl-[acp] + 2,3,4-saturated 2-lysophosphatidate = 2,3,4-saturated L-phosphatidate + holo-[acyl-carrier protein];palmitoyl-[acp] + 1-palmitoylglycerol 3-phosphate = dipalmitoyl phosphatidate + holo-[acyl-carrier protein];oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol = CoA + 1,2-dioleoyl-sn-phosphatidylinositol;myristoyl-CoA + 1-myristoyl-sn-glycerol 3-phosphate = CoA + 1,2-dimyristoyl-sn-glycerol 3-phosphate;lauroyl-CoA + 1-lauroyl-sn-glycerol 3-phosphate = CoA + 1,2-dilauroyl-sn-glycerol 3-phosphate;arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate" 1-oleyl-2-lyso-phosphatidate + oleoyl-CoA => dioleoyl phosphatidate + coenzyme A 4 out of 5 Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. {ECO:0000269|PubMed:22090344}. Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate <=> CoA + 1,2-diacyl-sn-glycerol 3-phosphate YES "Glycerolipid metabolism;Glycerophospholipid metabolism" pathway from kegg "E705;H70;H787" superpathway phosphatidate biosynthesis (yeast) // phospholipid remodeling (phosphatidate) "Glycerolipid metabolism;path:map00561;Glycerophospholipid metabolism;path:map00564;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" "lipid particle;endoplasmic reticulum membrane" "cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;lipid particle" "endoplasmic reticulum membrane;lipid particle" -906 YPR175W "Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate" 2.7.7.7 Second largest subunit of DNA polymerase II (DNA polymerase epsilon) DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. {ECO:0000269|PubMed:12124389}. 2.7.7.7 DNA polymerase epsilon subunit B (EC 2.7.7.7) (DNA polymerase II subunit 2) "DPB2; DNA polymerase epsilon noncatalytic subunit" 2.7.7.7 DNA Polymerase B subunit 2 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;DNA polymerase epsilon binds at the origin" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair" "Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -909 YPR187W "RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit" RNA polymerase subunit ABC23 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (ABC23) (DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide) "RPO26, RPB6; DNA-directed RNA polymerase core subunit RPO26" RNA POlymerase "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Binding of RRN3 to RNA Polymerase I;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase I Transcription Initiation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -910 YPR190C RNA polymerase III subunit C82 RNA polymerase III subunit C82 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (C82) (DNA-directed III 74 kDa polypeptide) (C74) "RPC82, RPC3, RPC80; DNA-directed RNA polymerase III subunit C82" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" -916 YLL018C-A "Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs" NA Protein required for cytochrome c oxidase assembly Required for the assembly of mitochondrial cytochrome c oxidase. {ECO:0000269|PubMed:12171940}. NA Cytochrome c oxidase assembly protein COX19 "COX19; Cox19p" NA Cytochrome c OXidase "MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds;MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds" NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 4 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA NA aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA "cytoplasm;mitochondrial membrane" "cytoplasm;mitochondrion;mitochondrial membrane" "mitochondrial membrane;cytoplasm" -918 YOL077W-A "Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase" Subunit k of the mitochondrial F1F0 ATP synthase Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. The K chain binds the dimeric form by interacting with the G and E chains. ATP synthase subunit K, mitochondrial "ATP19; F1F0 ATP synthase subunit K" ATP synthase ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] 4 out of 5 NA ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] YES Oxidative phosphorylation pathway from kegg "Oxidative phosphorylation;Metabolic pathways" superpathway of purine nucleotides de novo biosynthesis I // adenosine nucleotides de novo biosynthesis // adenosine ribonucleotides de novo biosynthesis NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane -921 YPL096C-A "Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein" Endoplasmic reticulum membrane protein that binds and inhibits Ras2p Probable component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. Ras may inhibit the enzyme activity of the GPI-GnT complex via the association between ERI1 and RAS2. {ECO:0000269|PubMed:12832483, ECO:0000269|PubMed:15163411}. Phosphatidylinositol N-acetylglucosaminyltransferase ERI1 subunit (GPI-GlcNAc transferase complex subunit ERI1) (GPI-GnT subunit ERI1) (Endoplasmic reticulum-associated Ras inhibitor protein 1) "ERI1, RIN1; Eri1p" ER-associated Ras Inhibitor UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 4 out of 5 NA UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis "atalyzes the first step in GPI-anchor biosynthesis; pathway from kegg" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000305|PubMed:12832483}." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +NO gene annotation_SGD ec_SGD protein_name_SGD annotation_uniprot ec_uniprot protein_name_uniprot annotation_kegg ec_kegg annotation_biocyc annotation_reactome reaction_found_in_Rhea_based_on_ecSGD reaction_found_in_Brenda_based_on_ecSGD reaction_found_in_Rhea_based_on_ecUniprot reaction_found_in_Brenda_based_on_ecUniprot reaction_biocyc reaction_kegg reaction_reactome Annotation_score reaction_uniprot Choosed_reaction manual_check subpathway note sign_for_ec_from_ecoli_human subsystem_SGD subsystem_uniprot subsystem_kegg subsystem_biocyc subsystem_reactome pathway_comprehensive compartment_uni compartment_sgd common_compartment +5 YAL026C "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ YES phospholipids transport "pathway from reactome;3.6.3.1 many transport reactions in human model" "E586;H449" "Neutrophil degranulation;Ion transport by P-type ATPases" NA Golgi "Golgi membrane;endoplasmic reticulum;Golgi;cell envelope" Golgi +7 YAL035W "Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2" 3.6.5.3 Translation initiation factor eIF5B Plays a role in translation initiation (PubMed:9624054). Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:12507428, PubMed:12471154, PubMed:12008673). GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome (PubMed:25478828). The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes (PubMed:12507428, PubMed:18976658, PubMed:19029250). Stimulates 20S pre-rRNA cleavage to mature 18S rRNA by PIN-domain endonuclease NOB1 (PubMed:22751017). {ECO:0000269|PubMed:12008673, ECO:0000269|PubMed:12471154, ECO:0000269|PubMed:12507428, ECO:0000269|PubMed:18976658, ECO:0000269|PubMed:19029250, ECO:0000269|PubMed:22751017, ECO:0000269|PubMed:25478828, ECO:0000269|PubMed:9624054}. 3.6.5.3 Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) "FUN12, yIF2; translation initiation factor eIF5B" NA Function Unknown Now NA NA "GTP + H2O = GDP + phosphate;XTP + H2O = XDP + phosphate;XDP + H2O = XMP + phosphate" NA "GTP + H2O = GDP + phosphate;XTP + H2O = XDP + phosphate;XDP + H2O = XMP + phosphate" NA NA NA 5 out of 5 GTP + H(2)O = GDP + phosphate. {ECO:0000269|PubMed:12507428, ECO:0000269|PubMed:18976658}. GTP + H(2)O = GDP + phosphate YES Nucleotide Salvage Pathway from e.coli NA E450 NA NA RNA transport NA NA NA cytoplasm "cytoplasm;mitochondrion" cytoplasm +8 YAL039C "Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in mitochondrial intermembrane space; human homolog HCCS implicated in microphthalmia with linear skin defects (MLS), and can complement yeast null mutant" 4.4.1.17 Cytochrome c heme lyase (holocytochrome c synthase) Links covalently the heme group to the apoprotein of cytochrome c. 4.4.1.17 Cytochrome c heme lyase (CCHL) (EC 4.4.1.17) (Holocytochrome-c synthase) "CYC3; holocytochrome c synthase CYC3" 4.4.1.17 cytochrome c heme lyase "holo-[cytochrome c] => apo-[cytochrome c] + heme b;apo-[cytochrome c] + heme b => holo-[cytochrome c]" "Cytochrome c <=> Apocytochrome c + Heme;c-type cytochrome = heme c + apo-[c-type cytochrome];Holocytochrome c = apocytochrome c + heme" "holo-[cytochrome c] => apo-[cytochrome c] + heme b;apo-[cytochrome c] + heme b => holo-[cytochrome c]" "Cytochrome c <=> Apocytochrome c + Heme;c-type cytochrome = heme c + apo-[c-type cytochrome];Holocytochrome c = apocytochrome c + heme" a c-type cytochrome <=> heme c + an apo-[c-type cytochrome] Cytochrome c <=> Apocytochrome c + Heme 3 out of 5 Holocytochrome c = apocytochrome c + heme. Cytochrome c <=> Apocytochrome c + Heme YES Porphyrin and chlorophyll metabolism pathway from kegg H991 Porphyrin and chlorophyll metabolism "Porphyrin and chlorophyll metabolism;path:map00860" mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +9 YAL061W "Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3" 1.1.1.303 Putative medium-chain alcohol dehydrogenase with similarity to BDH1 Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH. {ECO:0000305}. 1.1.1.303 Probable diacetyl reductase [(R)-acetoin forming] 2 (EC 1.1.1.303) "BDH2; putative dehydrogenase BDH2" "1.1.1.4;1.1.1.303" BDH2 "(R)-acetoin + NAD(+) => diacetyl + H(+) + NADH;diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)" (R)-acetoin + NAD+ = diacetyl + NADH + H+ "(R)-acetoin + NAD(+) => diacetyl + H(+) + NADH;diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)" (R)-acetoin + NAD+ = diacetyl + NADH + H+ "(R)-Acetoin + NAD+ <=> Diacetyl + NADH + H+;(R,R)-Butane-2,3-diol + NAD+ <=> (R)-Acetoin + NADH + H+;meso-2,3-Butanediol + NAD+ <=> (S)-Acetoin + NADH + H+" 3 out of 5 (R)-acetoin + NAD(+) = diacetyl + NADH. (R)-acetoin + NAD(+) <=> diacetyl + NADH YES Butanoate metabolism pathway from kegg Butanoate metabolism "Butanoate metabolism;path:map00650" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +21 YBL035C "B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation" B subunit of DNA polymerase alpha-primase complex Non-catalytic component of DNA polymerase alpha, which in a complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase. POL12 may play an essential role at the early stage of chromosomal DNA replication by coupling DNA polymerase alpha to the cellular replication machinery (By similarity). Interacts with MCM10. {ECO:0000250}. DNA polymerase alpha subunit B (DNA polymerase I subunit B) (DNA polymerase alpha:primase complex p86 subunit) (Pol alpha-primase complex p86 subunit) (DNA polymerase-primase complex p74 subunit) "POL12; DNA-directed DNA polymerase alpha subunit POL12" POLymerase "Detection of damage during initiation of DNA synthesis in S-phase;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere;RFC binding displaces Pol Alpha on the C-strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin;RFC binding displaces Pol Alpha;Loading of PCNA - Sliding Clamp Formation;RFC dissociates after sliding clamp formation;Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 NA 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA polymerase . Pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication" "Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand" NA nucleus nucleus nucleus +26 YBL057C "One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1" 3.1.1.29 One of two mitochondrially-localized peptidyl-tRNA hydrolases The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. {ECO:0000250, ECO:0000269|PubMed:12475929, ECO:0000269|PubMed:12799450}. 3.1.1.29 Peptidyl-tRNA hydrolase 2 (PTH 2) (EC 3.1.1.29) "PTH2; aminoacyl-tRNA hydrolase" 3.1.1.29 Peptidyl-Trna Hydrolase "N-acyl-L-alpha-aminoacyl-tRNA + H2O => an N-acyl-L-amino acid + H(+) + tRNA;an N-acyl-L-amino acid + H(+) + tRNA => N-acyl-L-alpha-aminoacyl-tRNA + H2O" "N-Substituted aminoacyl-tRNA + H2O <=> N-Substituted amino acid + tRNA;H2O + N-modified aminoacyl-[tRNA] = uncharged tRNA + N-modified amino acid + H+;L-asparaginyl-[tRNAasn] + H2O = L-asparagine + tRNAasn + H+;L-cysteinyl-[tRNAcys] + H2O = L-cysteine + tRNAcys + H+;N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA;diacetyl-lysyl-tRNALys + H2O = diacetyl-lysine + tRNALys;peptidyl-tRNAL + H2O = peptide + tRNA;peptidyl-tRNALys + H2O = peptide + tRNALys;peptidyl-tRNA + H2O = peptide + tRNA" "N-acyl-L-alpha-aminoacyl-tRNA + H2O => an N-acyl-L-amino acid + H(+) + tRNA;an N-acyl-L-amino acid + H(+) + tRNA => N-acyl-L-alpha-aminoacyl-tRNA + H2O" "N-Substituted aminoacyl-tRNA + H2O <=> N-Substituted amino acid + tRNA;H2O + N-modified aminoacyl-[tRNA] = uncharged tRNA + N-modified amino acid + H+;L-asparaginyl-[tRNAasn] + H2O = L-asparagine + tRNAasn + H+;L-cysteinyl-[tRNAcys] + H2O = L-cysteine + tRNAcys + H+;N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA;diacetyl-lysyl-tRNALys + H2O = diacetyl-lysine + tRNALys;peptidyl-tRNAL + H2O = peptide + tRNA;peptidyl-tRNALys + H2O = peptide + tRNALys;peptidyl-tRNA + H2O = peptide + tRNA" "an L-asparaginyl-[tRNAasn] + H2O => L-asparagine + tRNAasn + H+;an N-modified aminoacyl-[tRNA] + H2O => an uncharged tRNA + an N-modified amino acid + H+" 4 out of 5 N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA. N-acyl-L-alpha-aminoacyl-tRNA + H2O <=> an N-acyl-L-amino acid + H(+) + tRNA YES other "no subsystem from e.coli and human model; reaction from rhea" H1234 NA cytoplasm "cytoplasm;mitochondrion;mitochondrial membrane" cytoplasm +29 YBL080C "Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog" 6.3.5.- Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000269|PubMed:19417106}. 6.3.5.- Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112) "PET112; glutamyl-tRNA(Gln) amidotransferase subunit PET112" "6.3.5.6;6.3.5.7" PETite colonies "Glutaminyl-tRNA + L-Glutamate + Orthophosphate + ADP <=> L-Glutamyl-tRNA(Gln) + L-Glutamine + ATP + H2O;L-Asparaginyl-tRNA(Asn) + L-Glutamate + Orthophosphate + ADP <=> L-Aspartyl-tRNA(Asn) + L-Glutamine + ATP + H2O" 4 out of 5 ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. {ECO:0000255|HAMAP-Rule:MF_03147}. ATP + L-glutamyl-tRNA(Gln) + L-glutamine <=> ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate YES Aminoacyl-tRNA biosynthesis pathway from kegg "Aminoacyl-tRNA biosynthesis;Metabolic pathways" NA mitochondrion mitochondrion mitochondrion +30 YBL082C "Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; G353A missense mutation in human ortholog ALG3 implicated in carbohydrate deficient glycoprotein syndrome type IV, which is characterized by microcephaly, severe epilepsy, minimal psychomotor development, partial deficiency of sialic acids in serum glycoproteins; wild-type human ALG3 can complement yeast alg3 mutant" 2.4.1.258 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol. Sensitive to H.mrakii HM-1 killer toxin. {ECO:0000269|PubMed:11308030, ECO:0000269|PubMed:9108275}. 2.4.1.258 Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase) (HM-1 killer toxin resistance protein) "ALG3, RHK1; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase" 2.4.1.258 "dolichyl-P-Man:Man5GlcNAc2-PP-dolichol α-1,3-mannosyltransferase" Addition of the sixth mannose to the N-glycan precursor by ALG3. "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+ Dolichyl phosphate D-mannose + G00006 <=> Dolichyl phosphate + G10595 5 out of 5 Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:11308030}. Dolichyl phosphate D-mannose + G00006 <=> Dolichyl phosphate + G10595 YES N-Glycan biosynthesis pathway from kegg H1140 lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +32 YBL091C "Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p" 3.4.11.18 Methionine aminopeptidase Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays only a minor role in N-terminal methionine removal. Less efficient when the second residue is Val, Gly, Cys or Thr. {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:11811952, ECO:0000269|PubMed:12874831, ECO:0000269|PubMed:15547949, ECO:0000269|PubMed:8618900, ECO:0000269|PubMed:9177176}. 3.4.11.18 Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M) "MAP2; methionine aminopeptidase" 3.4.11.18 methionine aminopeptidase 2 "METAP1/2 demethylates GNAT1;Exocytosis of azurophil granule lumen proteins;Exocytosis of azurophil granule lumen proteins" "Met-Ala + H2O = Met + Ala;N-terminal-L-methionyl-L-alanyl-[protein] + H2O = N-terminal L-alanyl-[protein] + L-methionine;N-terminal-L-methionyl-L-cysteinyl-[protein] + H2O = N-terminal cysteinyl-[protein] + L-methionine;N-terminal-L-methionyl-glycyl-[protein] + H2O = N-terminal glycyl-[protein] + L-methionine;N-terminal-L-methionyl-L-seryl-[protein] + H2O = N-terminal L-seryl-[protein] + L-methionine;N-terminal-L-methionyl-L-threonyl-[protein] + H2O = N-terminal L-threonyl-[protein] + L-methionine;N-terminal-L-methionyl-L-valyl-[protein] + H2O = N-terminal L-valyl-[protein] + L-methionine;Met-peptide + H2O = Met + peptide" "Met-Ala + H2O = Met + Ala;N-terminal-L-methionyl-L-alanyl-[protein] + H2O = N-terminal L-alanyl-[protein] + L-methionine;N-terminal-L-methionyl-L-cysteinyl-[protein] + H2O = N-terminal cysteinyl-[protein] + L-methionine;N-terminal-L-methionyl-glycyl-[protein] + H2O = N-terminal glycyl-[protein] + L-methionine;N-terminal-L-methionyl-L-seryl-[protein] + H2O = N-terminal L-seryl-[protein] + L-methionine;N-terminal-L-methionyl-L-threonyl-[protein] + H2O = N-terminal L-threonyl-[protein] + L-methionine;N-terminal-L-methionyl-L-valyl-[protein] + H2O = N-terminal L-valyl-[protein] + L-methionine;Met-peptide + H2O = Met + peptide" a peptide with an N-terminal L-methionine + H2O => L-methionine + a peptide + H+ 5 out of 5 Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:8618900}. Met-Ala + H2O <=> Met + Ala YES other "Met-Ala + H2O = Met + Ala; hydrolysis of peptide bond" "Inactivation, recovery and regulation of the phototransduction cascade;Neutrophil degranulation" NA cytoplasm "nucleus;cytoplasm" cytoplasm +34 YBR001C "Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication" 3.2.1.28 Putative neutral trehalase, required for thermotolerance 3.2.1.28 Probable trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) "NTH2; alpha,alpha-trehalase NTH2" 3.2.1.28 neutral trehalase "alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose;alpha-D-glucose + beta-D-glucose => alpha,alpha-trehalose + H2O" "alpha,alpha-trehalose + H2O = 2 beta-D-glucose;alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose" "alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose;alpha-D-glucose + beta-D-glucose => alpha,alpha-trehalose + H2O" "alpha,alpha-trehalose + H2O = 2 beta-D-glucose;alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose" alpha,alpha-trehalose + H2O => beta-D-glucopyranose + alpha-D-glucopyranose alpha,alpha-Trehalose + H2O <=> 2 D-Glucose 3 out of 5 Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose. alpha,alpha-Trehalose + H2O <=> 2 D-Glucose YES Starch and sucrose metabolism pathway from kegg "E240;H561" "Starch and sucrose metabolism;Metabolic pathways" chitin biosynthesis // trehalose degradation II (trehalase) "Starch and sucrose metabolism;path:map00500;Metabolic pathways;path:map01100" "cytoplasm;mitochondrion" +35 YBR022W "Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing" "3.1.3.84;3.2.2.-" Phosphatase that is highly specific for ADP-ribose 1''-phosphate Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. {ECO:0000269|PubMed:10550052, ECO:0000269|PubMed:15684411, ECO:0000269|PubMed:23474712}. "3.1.3.84; 3.2.2.-" ADP-ribose 1''-phosphate phosphatase (EC 3.1.3.84) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase) "POA1; ADP-ribose 1''-phosphate phosphatase" 3.1.3.84 ADP-ribose 1''-phosphate phosphatase "ADP-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate;ADP-D-ribose + phosphate => ADP-D-ribose 1''-phosphate + H2O" ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate "ADP-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate;ADP-D-ribose + phosphate => ADP-D-ribose 1''-phosphate + H2O" ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate ADP ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate 3 out of 5 ADP-D-ribose 1''-phosphate + H(2)O = ADP-D-ribose + phosphate. ADP ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate YES other "NA;NA" tRNA splicing "NA;NA" +37 YBR046C "NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin" 1.6.5.5 NADPH-dependent quinone reductase 1.6.5.5 Probable quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) "ZTA1; NADPH:quinone reductase" 1.6.5.5 quinone oxidoreductase "2 a quinone + H(+) + NADPH => 2 a 1,4-benzosemiquinone + NADP(+);2 a 1,4-benzosemiquinone + NADP(+) => 2 a quinone + H(+) + NADPH" "2 Quinone + NADPH + H+ <=> 2 Semiquinone + NADP+;NADPH + quinone + H+ = NADP+ + semiquinone;NADPH + H+ + 2 quinone = NADP+ + 2 semiquinone" "2 a quinone + H(+) + NADPH => 2 a 1,4-benzosemiquinone + NADP(+);2 a 1,4-benzosemiquinone + NADP(+) => 2 a quinone + H(+) + NADPH" "2 Quinone + NADPH + H+ <=> 2 Semiquinone + NADP+;NADPH + quinone + H+ = NADP+ + semiquinone;NADPH + H+ + 2 quinone = NADP+ + 2 semiquinone" 2 a quinone + NADPH + H+ => 2 a semiquinone + NADP+ 3 out of 5 NADPH + 2 quinone = NADP(+) + 2 semiquinone. 2 a quinone + H(+) + NADPH <=> 2 a 1,4-benzosemiquinone + NADP(+) YES Tyrosine metabolism "pathway from recon3D; reaction from rhea" H676 NA "nucleus;cytoplasm" +41 YBR070C "Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to ER membrane; similar to bacterial and human glycosyltransferases; both human homologs ALG13 and ALG14 are required to complement yeast alg14 mutant" Component of UDP-GlcNAc transferase Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER. {ECO:0000269|PubMed:15615718, ECO:0000269|PubMed:16100110}. UDP-N-acetylglucosamine transferase subunit ALG14 (Asparagine-linked glycosylation protein 14) "ALG14; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14" 2.4.1.141 UDP-N-acetylglucosamine transferase Alg14p subunit ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP + H+ UDP-N-acetyl-D-glucosamine + N-Acetyl-D-glucosaminyldiphosphodolichol <=> UDP + N,N'-Chitobiosyldiphosphodolichol 5 out of 5 NA UDP-N-acetyl-D-glucosamine + N-Acetyl-D-glucosaminyldiphosphodolichol <=> UDP + N,N'-Chitobiosyldiphosphodolichol YES N-Glycan biosynthesis Essential for the second step of the dolichol-linked oligosaccharide pathway. Pathway from kegg lipid-linked oligosaccharide biosynthesis "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein NA "endoplasmic reticulum membrane;nucleus" "nucleus;endoplasmic reticulum;endoplasmic reticulum membrane" "nucleus;endoplasmic reticulum membrane" +45 YBR111C "Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate" 3.6.1.13 Nudix hydrolase family member with ADP-ribose pyrophosphatase activity 3.6.1.13 ADP-ribose pyrophosphatase (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) "YSA1, RMA2; ADP-ribose diphosphatase" 3.6.1.13 YSA1 Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP "ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate;GDP-mannose + H2O = GMP + D-mannose 1-phosphate;ADP-glucose + H2O = AMP + alpha-D-glucose 1-phosphate;ADP-mannose + H2O = AMP + D-mannose 1-phosphate" "ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate;GDP-mannose + H2O = GMP + D-mannose 1-phosphate;ADP-glucose + H2O = AMP + alpha-D-glucose 1-phosphate;ADP-mannose + H2O = AMP + D-mannose 1-phosphate" ADP-D-ribose + H2O = AMP + D-ribofuranose 5-phosphate + 2 H+ ADP-ribose + H2O <=> AMP + D-Ribose 5-phosphate Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP 4 out of 5 ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate. ADP-D-ribose + H2O <=> AMP + D-ribofuranose 5-phosphate + 2 H+ YES Purine metabolism pathway from kegg "E332;H61" Purine metabolism Phosphate bond hydrolysis by NUDT proteins "Purine metabolism;path:map00230" "nucleus;cytoplasm;mitochondrion" +51 YBR147W "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" Putative vacuolar membrane transporter for cationic amino acids May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) "RTC2, RRT11, YPQ3; cationic amino acid transporter" Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 4 out of 5 NA " L-Arg <=> L-Arg; L-His <=> L-His; L-Lys <=> L-Lys" YES "L-Arg transport (from lysosomal lumen to cytosol); L-His transport (from lysosomal lumen to cytosol); L-Lys transport (from lysosomal lumen to cytosol)" cationic amino acids transport Miscellaneous transport and binding events NA "vacuolar membrane;mitochondrial membrane" "mitochondrion;vacuole;vacuolar membrane;mitochondrial membrane" "mitochondrial membrane;vacuolar membrane" +52 YBR154C "RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation" RNA polymerase subunit ABC27 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerase complexes are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (ABC27) (DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide) "RPB5; DNA-directed RNA polymerase core subunit RPB5" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Binding of RRN3 to RNA Polymerase I;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase RNA polymerase. Pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase I Transcription Initiation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus +56 YBR177C "Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication" "2.3.1.84;3.1.1.-" Acyl-coenzymeA:ethanol O-acyltransferase Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification. {ECO:0000269|PubMed:16361250}. "2.3.1.84; 3.1.1.-" Medium-chain fatty acid ethyl ester synthase/esterase 2 (Alcohol O-acetyltransferase) (EC 2.3.1.84) (EC 3.1.1.-) (Ethanol hexanoyl transferase 1) "EHT1; medium-chain fatty acid ethyl ester synthase/esterase" NA alcohol acyl transferase ABHD3 hydrolyses LPC(14:0) to 1AGPC "acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA;an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol" "acetyl-CoA + a primary alcohol = CoA + an acetyl ester;butanol + acetyl-CoA = butyl acetate + CoA;phenylethyl alcohol + acetyl-CoA = phenylethyl acetate + CoA;geraniol + acetyl-CoA = CoA + geranyl acetate;coniferyl alcohol + acetyl-CoA = coniferyl acetate + CoA;isoamylalcohol + acetyl-CoA = isoamyl acetate + CoA;acetyl-CoA + alcohol = CoA + acetate" "acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA;an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol" "acetyl-CoA + a primary alcohol = CoA + an acetyl ester;butanol + acetyl-CoA = butyl acetate + CoA;phenylethyl alcohol + acetyl-CoA = phenylethyl acetate + CoA;geraniol + acetyl-CoA = CoA + geranyl acetate;coniferyl alcohol + acetyl-CoA = coniferyl acetate + CoA;isoamylalcohol + acetyl-CoA = isoamyl acetate + CoA;acetyl-CoA + alcohol = CoA + acetate" "butan-1-ol + acetyl-CoA => butyl acetate + coenzyme A;ethanol + acetyl-CoA => ethyl acetate + coenzyme A" NA ABHD3 hydrolyses LPC(14:0) to 1AGPC 5 out of 5 Acetyl-CoA + an alcohol = CoA + an acetyl ester. Acetyl-CoA + an alcohol = CoA + an acetyl ester YES Other NA "NA;NA" NA NA NA NA Synthesis of PC "NA;NA" "mitochondrion;mitochondrial membrane;lipid particle" +58 YBR222C "Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase" 6.-.-.- Oxalyl-CoA synthetase Non-essential protein involved in fatty acid metabolism. 6.-.-.- Peroxisomal-coenzyme A synthetase (EC 6.-.-.-) "PCS60, FAT2; Pcs60p" 6.2.1.8 PCS60 "ACSF2 ligates CoA-SH to MCFA;ACSF3 ligates CoA-SH to VLCFA" ATP + Oxalate + CoA <=> AMP + Diphosphate + Oxalyl-CoA ACSF3 ligates CoA-SH to VLCFA 4 out of 5 NA ATP + Oxalate + CoA <=> AMP + Diphosphate + Oxalyl-CoA YES Glyoxylate and dicarboxylate metabolism pathway from kegg Glyoxylate and dicarboxylate metabolism "Synthesis of very long-chain fatty acyl-CoAs;Mitochondrial Fatty Acid Beta-Oxidation" NA peroxisome "cytoplasm;peroxisome" peroxisome +59 YBR229C "Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations" 3.2.1.84 Glucosidase II catalytic subunit Catalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. {ECO:0000269|PubMed:16373354, ECO:0000269|PubMed:8910335}. 3.2.1.84 Glucosidase 2 subunit alpha (EC 3.2.1.84) (Alpha-glucosidase II subunit alpha) (Glucosidase II subunit alpha) (Reversal of TOR2 lethality protein 2) "ROT2, GLS2; glucan 1,3-alpha-glucosidase ROT2" 3.2.1.84 "α-glucosidase II α subunit" "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose;Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose;sucrose + H2O => glucose + fructose;sucrose + H2O => glucose + fructose;maltose + H2O => 2 D-glucose (maltase-glucoamylase);maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase);maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase);maltose + H2O => 2 D-glucose (sucrase-isomaltase);maltose + H2O => 2 D-glucose (sucrase-isomaltase);maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase);GAA hydrolyzes alpha(1,6) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,6) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,4) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,4) linkages in lysosomal glycogen;Removal of the third glucose by glucosidase II and release from the chaperone;isomaltose + H2O => 2 D-glucose (sucrase-isomaltase);isomaltose + H2O => 2 D-glucose (sucrase-isomaltase);Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins" "nigerose + H2O = 2 D-glucose;H2O + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;H2O + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GlcMan7GlcNAc2 + H2O = Man7GlcNAc2 + D-glucose;mutan = glucan;alpha-1,3-mutan + H2O = alpha-D-glucose;Glc2Man9GlcNAc2 + H2O = Man9GlcNAc2 + alpha-D-glucose" "nigerose + H2O = 2 D-glucose;H2O + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;H2O + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GlcMan7GlcNAc2 + H2O = Man7GlcNAc2 + D-glucose;mutan = glucan;alpha-1,3-mutan + H2O = alpha-D-glucose;Glc2Man9GlcNAc2 + H2O = Man9GlcNAc2 + alpha-D-glucose" "a [protein]-L-asparagine-[(glucosyl)2(mannosyl)9(N-acetylglucosaminyl)2] + H2O => a [protein]-L-asparagine-[glucosyl(mannosyl)9(N-acetylglucosaminyl)2] + D-glucopyranose;a [protein]-L-asparagine-[glucosyl(mannosyl)9(N-acetylglucosaminyl)2] + H2O => a [protein]-L-asparagine-[(mannosyl)9(N-acetylglucosaminyl)2] + D-glucopyranose" "H2O + G00171 <=> D-Glucose + G00010;H2O + G00010 <=> D-Glucose + G00011" "GAA hydrolyzes alpha(1,6) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,6) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,4) linkages in lysosomal glycogen;GAA hydrolyzes alpha(1,4) linkages in lysosomal glycogen" 5 out of 5 Hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D-glucans. "H2O + G00171 <=> D-Glucose + G00010;H2O + G00010 <=> D-Glucose + G00011" YES N-Glycan biosynthesis pathway from kegg "PATHWAY: Glycan metabolism; N-glycan metabolism." "N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (yeast) processing in the ER "Digestion of dietary carbohydrate;Lysosomal glycogen catabolism;Neutrophil degranulation;Calnexin/calreticulin cycle" "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum "mitochondrion;endoplasmic reticulum" endoplasmic reticulum +60 YBR235W "Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family" Vacuolar membrane cation-chloride cotransporter (CCC) Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation. {ECO:0000305|PubMed:23022132}. Vacuolar cation-chloride cotransporter 1 (Vacuolar homolog of CCC family protein 1) "VHC1; Vhc1p" Vacuolar protein Homologous to CCC family "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol;SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol;SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region" "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol;SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol;SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region;SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region" 4 out of 5 NA "Na+ <=> Na+; K+ <=> K+; Cl- <=> Cl-" YES "chloride transport; K+ transport; Na transport" Cation-coupled Cation-coupled Chloride cotransporters NA vacuolar membrane "vacuole;vacuolar membrane" vacuolar membrane +63 YBR241C "Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene; YBR241C has a paralog, VPS73, that arose from the whole genome duplication" NA Putative transporter, member of the sugar porter family NA NA Probable metabolite transport protein YBR241C hypothetical protein NA YBR241C "SLC2A5 transports fructose from extracellular region to cytosol;SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT7 and GLUT11 transport glucose and fructose;GLUT7 and GLUT11 transport glucose and fructose;SLC2A9 transports Fru, Glc, urate;GLUT1 tetramer binds 4xATP;GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP;GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol;SLC2A1 tetramer transports Glc from cytosol to Golgi lumen;Exocytosis of secretory granule membrane proteins;Exocytosis of secretory granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol;GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol;GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol;GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" NA NA NA NA NA NA "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT7 and GLUT11 transport glucose and fructose;GLUT7 and GLUT11 transport glucose and fructose;SLC2A9 transports Fru, Glc, urate;GLUT1 tetramer binds 4xATP;GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP;GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol;SLC2A1 tetramer transports Glc from cytosol to Golgi lumen;Exocytosis of secretory granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol;GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol;GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol;GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" 2 out of 5 NA " Fru <=> Fru; Gal <=> Gal; Glc <=> Glc" YES sugar transport sugar transport NA NA NA NA NA "Cellular hexose transport;Vitamin C (ascorbate) metabolism;Regulation of insulin secretion;Lactose synthesis;Neutrophil degranulation;Intestinal hexose absorption" NA vacuolar membrane "vacuole;vacuolar membrane" vacuolar membrane +64 YBR243C "UDP-N-acetyl-glucosamine-1-P transferase; transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin; human homolog DPAGT1 can complement yeast ALG7 mutant" 2.7.8.15 UDP-N-acetyl-glucosamine-1-P transferase Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides. 2.7.8.15 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (G1PT) (GPT) (N-acetylglucosamine-1-phosphate transferase) (Tunicamycin resistance protein 1) "ALG7, TUR1; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" 2.7.8.15 "UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase" Addition of N-acetyl-D-glucosamine to Dolichyl phosphate "dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP;N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP => dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol;UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP" "dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP;N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP => dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol;UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP" a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP UDP-N-acetyl-alpha-D-glucosamine + Dolichyl phosphate <=> UMP + N-Acetyl-D-glucosaminyldiphosphodolichol 5 out of 5 UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol. UDP-N-acetyl-alpha-D-glucosamine + Dolichyl phosphate <=> UMP + N-Acetyl-D-glucosaminyldiphosphodolichol YES N-Glycan biosynthesis pathway from kegg H289 lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +69 YBR278W "Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication" 2.7.7.7 Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. {ECO:0000269|PubMed:12124389}. 2.7.7.7 DNA polymerase epsilon subunit C (EC 2.7.7.7) (DNA polymerase II subunit C) "DPB3; DNA polymerase epsilon noncatalytic subunit" 2.7.7.7 DNA Polymerase B (II) subunit "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus +70 YBR281C "Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" 3.4.-.- Component of glutamine amidotransferase (GATase II) Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. {ECO:0000269|PubMed:17179087}. 3.4.-.- Probable di- and tripeptidase DUG2 (EC 3.4.-.-) (Deficient in utilization of glutathione protein 2) (GSH degradosomal complex subunit DUG2) "DUG2; glutamine amidotransferase subunit DUG2" Deficient in Utilization of Glutathione glutathione + H2O => L-cysteinyl-glycine + L-glutamate 5 out of 5 NA glutathione + H2O => L-cysteinyl-glycine + L-glutamate YES Glutathione metabolism pathway from biocyc. It is changed into Glutathione metabolism "H1096;H1295" glutathione degradation (DUG pathway) NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +72 YBR295W "Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function" 3.6.3.3 Cadmium transporting P-type ATPase Cadmium transporting P-type ATPase which plays a critical role in cadmium resistance by extruding intracellular cadmium. Capable of high affinity copper ion binding, but not active copper ion transport. May play a role in copper resistance by chelating and sequestering copper ions. {ECO:0000269|PubMed:10743563, ECO:0000269|PubMed:14534306, ECO:0000269|PubMed:17107946, ECO:0000269|PubMed:18753133, ECO:0000269|PubMed:21483812, ECO:0000269|PubMed:2249249, ECO:0000269|PubMed:7754711}. 3.6.3.3 P-type cation-transporting ATPase (EC 3.6.3.3) (Cadmium resistance protein 2) (Cadmium-translocating P-type ATPase) (Cd(2+)-exporting ATPase) "PCA1, CAD2, PAY2; cation-transporting P-type ATPase PCA1" 3.6.3.4 P-type Cation-transporting ATPase "ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate;ADP + Cd(2+)(out) + H(+) + phosphate => ATP + Cd(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Cd2+/in = ADP + phosphate + Cd2+/out;ATP + H2O + Pb2+/in = ADP + phosphate + Pb2+/out" "ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate;ADP + Cd(2+)(out) + H(+) + phosphate => ATP + Cd(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Cd2+/in = ADP + phosphate + Cd2+/out;ATP + H2O + Pb2+/in = ADP + phosphate + Pb2+/out" Cd2+[in] + ATP + H2O = Cd2+[out] + ADP + phosphate + H+ ATP + H2O <=> ADP + Orthophosphate 5 out of 5 ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out). Cd2+[in] + ATP + H2O <=> Cd2+[out] + ADP + phosphate + H+ YES Cadmium transport "E586;E622" NA cell envelope cell envelope cell envelope +73 YCL017C "Cysteine desulfurase; involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria" 2.8.1.7 Cysteine desulfurase Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs. {ECO:0000269|PubMed:10406803, ECO:0000269|PubMed:10551871, ECO:0000269|PubMed:14722066, ECO:0000269|PubMed:15220327, ECO:0000269|PubMed:8444805}. 2.8.1.7 Cysteine desulfurase, mitochondrial (EC 2.8.1.7) (tRNA-splicing protein SPL1) "NFS1, SPL1; Nfs1p" 2.8.1.7 L-cysteine desulfurase "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster;Frataxin binds iron;Sec is reduced to H2Se by SCLY;NFS1 transfers sulfur from cysteine onto MOCS3" "(sulfur carrier)-H + L-cysteine => (sulfur carrier)-SH + L-alanine;(sulfur carrier)-SH + L-alanine => (sulfur carrier)-H + L-cysteine" "L-cysteine sulfinic acid = L-alanine + sulfite;L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor;[Enzyme]-cysteine + L-Cysteine <=> [Enzyme]-S-sulfanylcysteine + L-Alanine;L-Cysteine + [Protein]-L-cysteine <=> L-Alanine + [Protein]-S-sulfanyl-L-cysteine;[Enzyme]-S-sulfanylcysteine + [Protein]-L-cysteine <=> [Enzyme]-cysteine + [Protein]-S-sulfanyl-L-cysteine;[L-cysteine desulfurase] L-cysteine persulfide + unsulfurated [sulfur carrier] = [L-cysteine desulfurase]-L-cysteine + sulfurated [sulfur carrier];L-cysteine + unsulfurated [sulfur carrier] = L-alanine + sulfurated [sulfur carrier];S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex = [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex;[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-cysteine = S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-alanine;S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex = [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex;[L-cysteine desulfurase] + L-cysteine = S-sulfanyl-[L-cysteine desulfurase] + L-alanine;ThiI sulfur-carrier protein + L-cysteine = S-sulfanyl-[ThiI sulfur-carrier protein] + L-alanine;[L-cysteine desulfurase]-L-cysteine + L-cysteine = [L-cysteine desulfurase] L-cysteine persulfide + L-alanine;[enzyme]-S-sulfanylcysteine + acceptor = [enzyme]-cysteine + S-sulfanyl-acceptor;L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine;L-cysteine + Slr0077 = L-alanine + Slr0077-SSH;L-cysteine + IscS = L-alanine + IscS-SSH;L-cysteine + RhdA = L-alanine + RhdA-SSH;L-cysteine + SufS = L-alanine + SufS-SSH;L-cysteine = L-alanine + sulfur;L-cysteine + MOC3 protein = L-alanine + S-sulfanyl-MOC3 protein;L-cysteine + SufE = L-alanine + S-sulfanyl-SufE" "(sulfur carrier)-H + L-cysteine => (sulfur carrier)-SH + L-alanine;(sulfur carrier)-SH + L-alanine => (sulfur carrier)-H + L-cysteine" "L-cysteine sulfinic acid = L-alanine + sulfite;L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor;[Enzyme]-cysteine + L-Cysteine <=> [Enzyme]-S-sulfanylcysteine + L-Alanine;L-Cysteine + [Protein]-L-cysteine <=> L-Alanine + [Protein]-S-sulfanyl-L-cysteine;[Enzyme]-S-sulfanylcysteine + [Protein]-L-cysteine <=> [Enzyme]-cysteine + [Protein]-S-sulfanyl-L-cysteine;[L-cysteine desulfurase] L-cysteine persulfide + unsulfurated [sulfur carrier] = [L-cysteine desulfurase]-L-cysteine + sulfurated [sulfur carrier];L-cysteine + unsulfurated [sulfur carrier] = L-alanine + sulfurated [sulfur carrier];S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex = [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex;[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-cysteine = S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-alanine;S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex = [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex;[L-cysteine desulfurase] + L-cysteine = S-sulfanyl-[L-cysteine desulfurase] + L-alanine;ThiI sulfur-carrier protein + L-cysteine = S-sulfanyl-[ThiI sulfur-carrier protein] + L-alanine;[L-cysteine desulfurase]-L-cysteine + L-cysteine = [L-cysteine desulfurase] L-cysteine persulfide + L-alanine;[enzyme]-S-sulfanylcysteine + acceptor = [enzyme]-cysteine + S-sulfanyl-acceptor;L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine;L-cysteine + Slr0077 = L-alanine + Slr0077-SSH;L-cysteine + IscS = L-alanine + IscS-SSH;L-cysteine + RhdA = L-alanine + RhdA-SSH;L-cysteine + SufS = L-alanine + SufS-SSH;L-cysteine = L-alanine + sulfur;L-cysteine + MOC3 protein = L-alanine + S-sulfanyl-MOC3 protein;L-cysteine + SufE = L-alanine + S-sulfanyl-SufE" "a [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-cysteine => an S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-alanine;an S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex => a [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex;an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex => a [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex;an [L-cysteine desulfurase] L-cysteine persulfide + an unsulfurated [sulfur carrier] <=> an [L-cysteine desulfurase]-L-cysteine + a sulfurated [sulfur carrier];an [L-cysteine desulfurase]-L-cysteine + L-cysteine => an [L-cysteine desulfurase] L-cysteine persulfide + L-alanine;L-cysteine + an unsulfurated [sulfur carrier] => L-alanine + a sulfurated [sulfur carrier]" "[Enzyme]-cysteine + L-Cysteine <=> [Enzyme]-S-sulfanylcysteine + L-Alanine;L-Cysteine + [Protein]-L-cysteine <=> L-Alanine + [Protein]-S-sulfanyl-L-cysteine;[Enzyme]-S-sulfanylcysteine + [Protein]-L-cysteine <=> [Enzyme]-cysteine + [Protein]-S-sulfanyl-L-cysteine" "Sec is reduced to H2Se by SCLY;NFS1 transfers sulfur from cysteine onto MOCS3" 5 out of 5 L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor. {ECO:0000269|PubMed:15220327}. (sulfur carrier)-H + L-cysteine <=> (sulfur carrier)-SH + L-alanine YES iron-sulfur cluster biosynthesis "pathway from biocyc; reaction from rhea" "Thiamine metabolism;Metabolic pathways;Sulfur relay system" iron-sulfur cluster biosynthesis // tRNA-uridine 2-thiolation (yeast mitochondria) "Mitochondrial iron-sulfur cluster biogenesis;Metabolism of ingested SeMet, Sec, MeSec into H2Se;Molybdenum cofactor biosynthesis" "Thiamine metabolism;path:map00730;Metabolic pathways;path:map01100" mitochondrion "nucleus;mitochondrion" mitochondrion +77 YCL047C "Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion" 2.7.7.1 Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT) Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Involved in the salvage pathway for NAD(+) biosynthesis via NMN (PubMed:24759102). Involved in the filamentation pathway. Suppresses the filamentation defect of a KSS1 deletion (PubMed:21460040). {ECO:0000269|PubMed:21460040, ECO:0000269|PubMed:24759102}. 2.7.7.1 Nicotinamide mononucleotide adenylyltransferase (NMN adenylyltransferase) (NMNAT) (EC 2.7.7.1) (NMN-specific adenylyltransferase) (Promoter of filamentation protein 1) "POF1; nicotinamide-nucleotide adenylyltransferase" 2.7.7.1 Promoter Of Filamentation "beta-nicotinamide D-ribonucleotide + ATP + H(+) => diphosphate + NAD(+);diphosphate + NAD(+) => beta-nicotinamide D-ribonucleotide + ATP + H(+)" "ATP + nicotinamide ribonucleotide = diphosphate + NAD+;ATP + beta-nicotinate D-ribonucleotide = diphosphate + deamido-NAD+;tiazofurin monophosphate + ATP = tiazofurin adenine dinucleotide + diphosphate" "beta-nicotinamide D-ribonucleotide + ATP + H(+) => diphosphate + NAD(+);diphosphate + NAD(+) => beta-nicotinamide D-ribonucleotide + ATP + H(+)" "ATP + nicotinamide ribonucleotide = diphosphate + NAD+;ATP + beta-nicotinate D-ribonucleotide = diphosphate + deamido-NAD+;tiazofurin monophosphate + ATP = tiazofurin adenine dinucleotide + diphosphate" "ATP + Nicotinamide D-ribonucleotide <=> Diphosphate + NAD+;ATP + Nicotinate D-ribonucleotide <=> Diphosphate + Deamino-NAD+" 5 out of 5 ATP + nicotinamide ribonucleotide = diphosphate + NAD(+). {ECO:0000269|PubMed:24759102}. beta-nicotinamide D-ribonucleotide + ATP + H(+) <=> diphosphate + NAD(+) YES Nicotinate and nicotinamide metabolism "pathway from kegg; reaction from rhea" "E78;H422" "PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. {ECO:0000305|PubMed:24759102}." "Nicotinate and nicotinamide metabolism;Metabolic pathways" "Nicotinate and nicotinamide metabolism;path:map00760;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +81 YCR011C Putative ATP-dependent permease of the ABC transporter family Putative ATP-dependent permease of the ABC transporter family Probable ATP-dependent permease "ADP1; putative ATP-dependent permease ADP1" ATP-Dependent Permease "ABCG4 may mediate cholesterol efflux;ABCG1-mediated transport of intracellular cholesterol to the cell surface;ABCG2 dimer transports heme from cytosol to extracellular region" "ABCG4 may mediate cholesterol efflux;ABCG1-mediated transport of intracellular cholesterol to the cell surface" 3 out of 5 NA cholesterol <=> cholesterol YES cholesterol transport "ABC transporters in lipid homeostasis;HDL remodeling;Iron uptake and transport" NA endoplasmic reticulum membrane "vacuole;cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" endoplasmic reticulum membrane +82 YCR014C "DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta" 2.7.7.7 DNA polymerase IV Repair polymerase. Involved in gap-filling in DNA nonhomologous end joining (NHEJ) required for double-strand break repair. Seems to conduct DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Preferentially acts upon short gaps formed by the alignment of linear duplexes with complementary single-strand ends. Required for filling gaps that need removal of a 5'- or 3'-terminal mismatch, however lacks nuclease activities. {ECO:0000269|PubMed:10438542, ECO:0000269|PubMed:12235149, ECO:0000269|PubMed:8065914}. 2.7.7.7 DNA polymerase IV (POL IV) (EC 2.7.7.7) "POL4; DNA-directed DNA polymerase IV" 2.7.7.7 POLymerase "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA synthesis. Pathway obtained by comparing the ec H1117 Non-homologous end-joining "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus +88 YCR068W "Phospholipase; preferentially hydrolyses phosphatidylserine, with minor activity against cardiolipin and phosphatidylethanolamine; required for lysis of autophagic and CVT bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway; required for the maintenance of lipid droplet quantity after the diauxic shift; regulates lipolysis; expression regulated by Yap1p during autophagy" 3.1.1.3 Phospholipase Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension. {ECO:0000269|PubMed:11085977, ECO:0000269|PubMed:11264288, ECO:0000269|PubMed:11566994, ECO:0000269|PubMed:12499386, ECO:0000269|PubMed:18690010, ECO:0000269|PubMed:21364763, ECO:0000269|PubMed:21777356}. 3.1.1.3 Putative lipase ATG15 (EC 3.1.1.3) (Autophagy-related protein 15) (Cytoplasm to vacuole targeting protein 17) "ATG15, AUT5, CVT17; triglyceride lipase ATG15" 3.1.1.3 lipase "retinyl palmitate + H2O = retinol + palmitate;methyl acetate + H2O = methanol + acetate;tributyrin + H2O = dibutyrin + butyrate;1,2-Diacyl-sn-glycerol + H2O <=> 1-Acylglycerol + Fatty acid;triacylglycerol + H2O = diacylglycerol + a carboxylate;diacylglycerol + H2O = monoacylglycerol + a carboxylate;4-nitrophenyl butyrate + H2O = 4-nitrophenol + butyrate;triolein + H2O = diolein + oleate;Triacylglycerol + H2O <=> 1,2-Diacyl-sn-glycerol + Fatty acid;1,2-Diacyl-sn-glycerol + H2O <=> 2-Acylglycerol + Fatty acid;dietary all-trans-retinyl ester + H2O = all-trans-retinol + long-chain fatty acid + H+;triglyceride + H2O = 1,2-diglyceride + fatty acid + H+;tripalmitin + H2O = dipalmitin + palmitate;tricaprylin + H2O = dicaprylin + caprylate;trimyristin + H2O = dimyristin + myristate;(RS)-1-phenylethanol + vinyl acetate = (R)-1-phenylethyl acetate + acetaldehyde + (S)-1-phenylethanol" "retinyl palmitate + H2O = retinol + palmitate;methyl acetate + H2O = methanol + acetate;tributyrin + H2O = dibutyrin + butyrate;1,2-Diacyl-sn-glycerol + H2O <=> 1-Acylglycerol + Fatty acid;triacylglycerol + H2O = diacylglycerol + a carboxylate;diacylglycerol + H2O = monoacylglycerol + a carboxylate;4-nitrophenyl butyrate + H2O = 4-nitrophenol + butyrate;triolein + H2O = diolein + oleate;Triacylglycerol + H2O <=> 1,2-Diacyl-sn-glycerol + Fatty acid;1,2-Diacyl-sn-glycerol + H2O <=> 2-Acylglycerol + Fatty acid;dietary all-trans-retinyl ester + H2O = all-trans-retinol + long-chain fatty acid + H+;triglyceride + H2O = 1,2-diglyceride + fatty acid + H+;tripalmitin + H2O = dipalmitin + palmitate;tricaprylin + H2O = dicaprylin + caprylate;trimyristin + H2O = dimyristin + myristate;(RS)-1-phenylethanol + vinyl acetate = (R)-1-phenylethyl acetate + acetaldehyde + (S)-1-phenylethanol" a triglyceride + H2O => a 1,2-diglyceride + a fatty acid + H+ "Triacylglycerol + H2O <=> 1,2-Diacyl-sn-glycerol + Fatty acid;1,2-Diacyl-sn-glycerol + H2O <=> 1-Acylglycerol + Fatty acid" 5 out of 5 Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. "Triacylglycerol + H2O <=> 1,2-Diacyl-sn-glycerol + Fatty acid;1,2-Diacyl-sn-glycerol + H2O <=> 1-Acylglycerol + Fatty acid" YES Glycerolipid metabolism pathway from kegg "H367;H721;H1070" "Glycerolipid metabolism;Metabolic pathways;Autophagy - yeast" triacylglycerol degradation "Glycerolipid metabolism;path:map00561;Metabolic pathways;path:map01100" "endoplasmic reticulum membrane;Golgi membrane;cytoplasm" "Golgi membrane;cytoplasm;vacuole;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi" "Golgi membrane;endoplasmic reticulum membrane;cytoplasm" +92 YCR107W "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog, AAD15, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" Putative aryl-alcohol dehydrogenase 1.1.1.- Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) "AAD3; putative aryl-alcohol dehydrogenase" aryl-alcohol dehydrogenase "3-chlorobenzyl alcohol + NAD+ = 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ = 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ = 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ = p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ = 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ = an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ = benzaldehyde + NADH + H+" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism "pathway from E.coli model; reaction from biocyc" "E646;E743;H1286" NA +94 YEL002C "Beta subunit of the oligosaccharyl transferase glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum; human homolog DDOST can complement yeast growth defect during down-regulation of yeast gene" 2.4.99.18 Beta subunit of the oligosaccharyl transferase glycoprotein complex Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1 (Oligosaccharyl transferase subunit WBP1) (EC 2.4.99.18) (Oligosaccharyl transferase subunit beta) "WBP1; dolichyl-diphosphooligosaccharide-protein glycotransferase" NA "oligosaccharyl transferase complex β subunit" "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA NA 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis "pathway from kegg; reaction not sure" NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps Neutrophil degranulation "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "nucleus;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +95 YEL004W "Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER" Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc) and is required for cell wall chitin synthesis. {ECO:0000269|PubMed:10788474}. UDP-N-acetylglucosamine transporter YEA4 "YEA4; Yea4p" YEA4 "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen;SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen" "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen;SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen" 4 out of 5 NA UDP-GlcNAc <=> UDP-GlcNAc YES "Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transport; UDP-xylose[c] => UDP-xylose[g]; UDP-GlcNAc[c] <=> UDP-GlcNAc[g]" UDP-N-acetylglucosamine Transport of nucleotide sugars NA "endoplasmic reticulum;endoplasmic reticulum membrane" "endoplasmic reticulum;endoplasmic reticulum membrane;Golgi membrane" "endoplasmic reticulum;endoplasmic reticulum membrane" +96 YEL011W "Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease" 2.4.1.18 Glycogen branching enzyme, involved in glycogen accumulation 2.4.1.18 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Glycogen-branching enzyme) "GLC3, GHA1; 1,4-alpha-glucan branching enzyme" 2.4.1.18 1,4-glucan-6-(1,4-glucano)-transferase "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a;GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a;GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b" "glycogen + H2O = maltooligosaccharides;amylopectin + H2O = malto-oligosaccharides;1,4-alpha-D-glucan = (1,6)-alpha-D-glucosyl-(1,4)-alpha-glucan + H2O;glucosylated glycogenin = glycogen;2 1,4-alpha-D-glucan = alpha-1,4-D-glucan-alpha-1,6-(alpha-1,4-D-glucan) + H2O" "glycogen + H2O = maltooligosaccharides;amylopectin + H2O = malto-oligosaccharides;1,4-alpha-D-glucan = (1,6)-alpha-D-glucosyl-(1,4)-alpha-glucan + H2O;glucosylated glycogenin = glycogen;2 1,4-alpha-D-glucan = alpha-1,4-D-glucan-alpha-1,6-(alpha-1,4-D-glucan) + H2O" "a 1,4-alpha-D-glucan = a glycogen;a glucosylated glycogenin => a glycogen" Amylose <=> Starch "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a;GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a;GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b" 3 out of 5 Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. glygn1[c] => glygn2[c] YES Starch and sucrose metabolism pathway from kegg, reaction from human model, This reaction: [c] : glycogen --> bglycogen from E.coli, which is much simple. "E570;H281" glycogen biosynthesis "PATHWAY: Glycan biosynthesis; glycogen biosynthesis." "Starch and sucrose metabolism;path:map00500;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" glycogen biosynthesis Glycogen synthesis "Starch and sucrose metabolism;path:map00500;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" cytoplasm +101 YEL031W "P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1" 3.6.3.- P-type ATPase, ion transporter of the ER membrane Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. {ECO:0000269|PubMed:24392018}. 3.6.3.- Manganese-transporting ATPase 1 (EC 3.6.3.-) "SPF1, COD1, PER9, PIO1; ion-transporting P-type ATPase SPF1" Sensitivity to Pichia Farinosa killer toxin ATP13A1 transports Mn2+ from cytosol to ER lumen ATP13A1 transports Mn2+ from cytosol to ER lumen 5 out of 5 ATP + H(2)O = ADP + phosphate. Mn2+ <=> Mn2+ YES Mn2+ transport transports Mn2+ from cytosol to ER lumen Ion transport by P-type ATPases NA endoplasmic reticulum membrane "mitochondrion;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi;cell envelope" endoplasmic reticulum membrane +107 YEL064C "Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" NA Putative transporter Probable amino acid transporter of unknown specificity. {ECO:0000269|PubMed:11274162}. NA Vacuolar amino acid transporter 2 "AVT2; Avt2p" NA Amino acid Vacuolar Transport "Glutamine transport from astrocytes;L-Glutamine transport into neurons;SLC38A2 (ATA2)-mediated uptake of neutral amino acids;SLC38A1 (ATA1)-mediated uptake of neutral amino acids;SLC38A4 (ATA3)-mediated uptake of arginine and lysine;SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine;SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" NA NA NA NA NA NA "SLC38A4 (ATA3)-mediated uptake of arginine and lysine;SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine;SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" 3 out of 5 NA "arginine <=> arginine; lysine <=> lysine; glutamine <=> glutamine; histidine <=> histidine; asparagine <=> asparagine; alanine <=> alanine ; serine <=> serine" YES "amio acid transport; uptake of amino acids" NA NA NA NA NA "Astrocytic Glutamate-Glutamine Uptake And Metabolism;Glutamate Neurotransmitter Release Cycle;Amino acid transport across the plasma membrane" NA vacuolar membrane "vacuole;vacuolar membrane;endoplasmic reticulum" vacuolar membrane +108 YEL066W "D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; acetylates histones and polyamines, also autoacetylates" "2.3.1.36;2.3.1.48" D-Amino acid N-acetyltransferase that detoxifies D-amino acids N-acetyltransferase that acetylates histone H4 at 'Lys-8'. Also acetylates polyamines like putrescine, spermidine and spermine (PubMed:23775086). Acts on a wide range of D-amino acids. Catalyzes the N-acetylation through an ordered bi-bi mechanism, in which acetyl-CoA is the first substrate to be bound and CoA is the last product to be liberated (PubMed:15375647). D-amino acids are toxic for the cell and their N-acetylation, preceding removal from cells, plays an important role in detoxification of D-amino acids (PubMed:10600387, PubMed:16362288). {ECO:0000269|PubMed:10600387, ECO:0000269|PubMed:15375647, ECO:0000269|PubMed:16362288, ECO:0000269|PubMed:23775086}. "2.3.1.36; 2.3.1.48" D-amino-acid N-acetyltransferase HPA3 (DNT) (EC 2.3.1.36) (EC 2.3.1.48) (Histone and other protein acetyltransferase 3) "HPA3; D-amino-acid N-acetyltransferase" 2.3.1.36 Histone and other Protein Acetyltransferase "a D-amino acid + acetyl-CoA => an N-acetyl-D-amino acid + CoA + H(+);an N-acetyl-D-amino acid + CoA + H(+) => a D-amino acid + acetyl-CoA;[histone]-L-lysine + acetyl-CoA => [histone]-N(6)-acetyl-L-lysine + CoA + H(+);[histone]-N(6)-acetyl-L-lysine + CoA + H(+) => [histone]-L-lysine + acetyl-CoA;[protein]-L-lysine + acetyl-CoA => [protein]-N(6)-acetyl-L-lysine + CoA + H(+);[protein]-N(6)-acetyl-L-lysine + CoA + H(+) => [protein]-L-lysine + acetyl-CoA" "acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid;acetyl-CoA + D-phenylalanine = CoA + N-acetyl-D-phenylalanine;propionyl-CoA + D-alanine = CoA + N-propionyl-D-alanine;acetyl-CoA + D-cysteine = CoA + N-acetyl-D-cysteine;acetyl-CoA + D-tyrosine = CoA + N-acetyl-D-tyrosine;acetyl-CoA + D-leucine = CoA + N-acetyl-D-leucine;acetyl-CoA + D-threonine = CoA + N-acetyl-D-threonine;acetyl-CoA + D-valine = CoA + N-acetyl-D-valine;acetyl-CoA + D-alanine = CoA + N-acetyl-D-alanine;acetyl-CoA + D-glutamine = CoA + N-acetyl-D-glutamine;acetyl-CoA + D-asparagine = CoA + N-acetyl-D-asparagine;acetyl-CoA + D-asparaginate = CoA + N-acetyl-D-asparaginate;acetyl-CoA + D-histidine = CoA + N-acetyl-D-histidine;acetyl-CoA + D-norvaline = CoA + N-acetyl-D-norvaline;acetyl-CoA + D-serine = CoA + N-acetyl-D-serine;acetyl-CoA + D-cystine = CoA + N-acetyl-D-cystine;acetyl-CoA + D-isoleucine = CoA + N-acetyl-D-isoleucine;acetyl-CoA + norleucine = CoA + N-acetyl-D-norleucine;acetyl-CoA + D-proline = CoA + N-acetyl-D-proline;acetyl-CoA + D-methionine = CoA + N-acetyl-D-methionine;propionyl-CoA + D-leucine = CoA + N-propionyl-D-leucine;propionyl-CoA + D-glutamine = CoA + N-propionyl-D-glutamine;propionyl-CoA + D-allo-isoleucine = CoA + N-propionyl-D-allo-isoleucine;propionyl-CoA + D-serine = CoA + N-propionyl-D-serine;propionyl-CoA + D-tryptophan = CoA + N2-propionyl-D-tryptophan;Acetyl-CoA + Histone-L-lysine <=> CoA + Histone N6-acetyl-L-lysine;acetyl-CoA + [histone]-L-lysine = [histone]-N6-acetyl-L-lysine + coenzyme A + H+;acetyl-CoA + histone H4 = CoA + acetylhistone H4;4 acetyl-CoA + histone H4 = 4 CoA + tetraacetylhistone H4;histone H4 + acetyl-CoA = acetyl-histone H4 + CoA;acetyl-CoA + p53 = CoA + acetyl-p53;histone H3 + acetyl-CoA = acetyl-histone H3 + CoA;acetyl-CoA + histone H3 = CoA + acetylhistone H3;acetyl-CoA + histone H2A = CoA + acetylhistone H2A;piccoloNuA4 peptide + acetyl-CoA = acetyl-piccoloNuA4 peptide + CoA;acetyl-CoA + c-Myc = CoA + acetylated c-Myc;androgen receptor + acetyl-CoA = acetylated androgen receptor + CoA;acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine;acetyl-CoA + histone H = CoA + acetylhistone H;ATM kinase + acetyl-CoA = acetylated ATM kinase + CoA;promyelotic leukemia zinc finger gene + acetyl-CoA = acetylated promyelotic leukemia zinc finger gene + CoA;acetyl-CoA + beta-site amyloid precursor protein-cleaving enzyme 1 = CoA + acetylated beta-site amyloid precursor protein-cleaving enzyme 1;acetyl-CoA + p50 protein = CoA + acetyl-p50 protein;acetyl-CoA + p65 protein = CoA + acetyl-p65 protein;acetyl-CoA + histone = CoA + acetylhistone" "a D-amino acid + acetyl-CoA => an N-acetyl-D-amino acid + CoA + H(+);an N-acetyl-D-amino acid + CoA + H(+) => a D-amino acid + acetyl-CoA;[histone]-L-lysine + acetyl-CoA => [histone]-N(6)-acetyl-L-lysine + CoA + H(+);[histone]-N(6)-acetyl-L-lysine + CoA + H(+) => [histone]-L-lysine + acetyl-CoA;[protein]-L-lysine + acetyl-CoA => [protein]-N(6)-acetyl-L-lysine + CoA + H(+);[protein]-N(6)-acetyl-L-lysine + CoA + H(+) => [protein]-L-lysine + acetyl-CoA" "acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid;acetyl-CoA + D-phenylalanine = CoA + N-acetyl-D-phenylalanine;propionyl-CoA + D-alanine = CoA + N-propionyl-D-alanine;acetyl-CoA + D-cysteine = CoA + N-acetyl-D-cysteine;acetyl-CoA + D-tyrosine = CoA + N-acetyl-D-tyrosine;acetyl-CoA + D-leucine = CoA + N-acetyl-D-leucine;acetyl-CoA + D-threonine = CoA + N-acetyl-D-threonine;acetyl-CoA + D-valine = CoA + N-acetyl-D-valine;acetyl-CoA + D-alanine = CoA + N-acetyl-D-alanine;acetyl-CoA + D-glutamine = CoA + N-acetyl-D-glutamine;acetyl-CoA + D-asparagine = CoA + N-acetyl-D-asparagine;acetyl-CoA + D-asparaginate = CoA + N-acetyl-D-asparaginate;acetyl-CoA + D-histidine = CoA + N-acetyl-D-histidine;acetyl-CoA + D-norvaline = CoA + N-acetyl-D-norvaline;acetyl-CoA + D-serine = CoA + N-acetyl-D-serine;acetyl-CoA + D-cystine = CoA + N-acetyl-D-cystine;acetyl-CoA + D-isoleucine = CoA + N-acetyl-D-isoleucine;acetyl-CoA + norleucine = CoA + N-acetyl-D-norleucine;acetyl-CoA + D-proline = CoA + N-acetyl-D-proline;acetyl-CoA + D-methionine = CoA + N-acetyl-D-methionine;propionyl-CoA + D-leucine = CoA + N-propionyl-D-leucine;propionyl-CoA + D-glutamine = CoA + N-propionyl-D-glutamine;propionyl-CoA + D-allo-isoleucine = CoA + N-propionyl-D-allo-isoleucine;propionyl-CoA + D-serine = CoA + N-propionyl-D-serine;propionyl-CoA + D-tryptophan = CoA + N2-propionyl-D-tryptophan;Acetyl-CoA + Histone-L-lysine <=> CoA + Histone N6-acetyl-L-lysine;acetyl-CoA + [histone]-L-lysine = [histone]-N6-acetyl-L-lysine + coenzyme A + H+;acetyl-CoA + histone H4 = CoA + acetylhistone H4;4 acetyl-CoA + histone H4 = 4 CoA + tetraacetylhistone H4;histone H4 + acetyl-CoA = acetyl-histone H4 + CoA;acetyl-CoA + p53 = CoA + acetyl-p53;histone H3 + acetyl-CoA = acetyl-histone H3 + CoA;acetyl-CoA + histone H3 = CoA + acetylhistone H3;acetyl-CoA + histone H2A = CoA + acetylhistone H2A;piccoloNuA4 peptide + acetyl-CoA = acetyl-piccoloNuA4 peptide + CoA;acetyl-CoA + c-Myc = CoA + acetylated c-Myc;androgen receptor + acetyl-CoA = acetylated androgen receptor + CoA;acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine;acetyl-CoA + histone H = CoA + acetylhistone H;ATM kinase + acetyl-CoA = acetylated ATM kinase + CoA;promyelotic leukemia zinc finger gene + acetyl-CoA = acetylated promyelotic leukemia zinc finger gene + CoA;acetyl-CoA + beta-site amyloid precursor protein-cleaving enzyme 1 = CoA + acetylated beta-site amyloid precursor protein-cleaving enzyme 1;acetyl-CoA + p50 protein = CoA + acetyl-p50 protein;acetyl-CoA + p65 protein = CoA + acetyl-p65 protein;acetyl-CoA + histone = CoA + acetylhistone" Acetyl-CoA + D-Phenylalanine <=> CoA + N-Acetyl-D-phenylalanine 5 out of 5 "Acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid. {ECO:0000269|PubMed:15375647}.; Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine. {ECO:0000269|PubMed:23775086}." "Acetyl-CoA + a D-amino acid <=> CoA + an N-acetyl-D-amino acid; Acetyl-CoA + [protein]-L-lysine <=> CoA + [protein]-N(6)-acetyl-L-lysine" YES other pathway from kegg "NA;NA" Phenylalanine metabolism "Phenylalanine metabolism;path:map00360;NA" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +109 YEL070W "Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication" Mannitol dehydrogenase 1.1.1.- Mannitol dehydrogenase DSF1 (EC 1.1.1.-) (Deletion suppressor of MPT5 mutation protein 1) "DSF1, MAN1; mannitol dehydrogenase DSF1" 1.1.1.67 Deletion Suppressor of mptFive/pufFive mutation Mannitol + NAD+ <=> D-Fructose + NADH + H+ 2 out of 5 NA Mannitol + NAD+ <=> D-Fructose + NADH + H+ YES Fructose and mannose metabolism pathway from kegg "E646;E743;H1286" Fructose and mannose metabolism NA +110 YER001W "Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family" 2.4.1.- Alpha-1,3-mannosyltransferase Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications. 2.4.1.- Alpha-1,3-mannosyltransferase MNN1 (EC 2.4.1.-) "MNN1; alpha-1,3-mannosyltransferase MNN1" "α-1,3-mannosyltransferase MMN1" GDP-alpha-D-mannose + an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] => an alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] + GDP + H+ "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" 4 out of 5 NA "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" YES Various types of N-glycan biosynthesis pathway from kegg "H815;H837;H838;H839" "PATHWAY: Protein modification; protein glycosylation." "Various types of N-glycan biosynthesis;Other types of O-glycan biosynthesis;Metabolic pathways" protein O-mannosylation I (yeast) NA Golgi membrane "Golgi membrane;Golgi" Golgi membrane +111 YER010C "Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate" "4.1.1.3;4.1.3.17" Bifunctional HMG aldolase/oxaloacetate decarboxylase Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions. {ECO:0000269|PubMed:24359411}. "4.1.3.17; 4.1.1.3" 4-hydroxy-4-methyl-2-oxoglutarate aldolase (HMG aldolase) (EC 4.1.3.17) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.3) (Regulator of ribonuclease activity homolog) (RraA-like protein) bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase Unknown "NA;4-hydroxy-4-methyl-2-oxoglutarate => 2 pyruvate;2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate;2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => oxaloacetate + pyruvate;oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate" "oxaloacetate = pyruvate + CO2;2-Oxobutanoate + CO2 <=> Methyloxaloacetate;4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate;4-carboxy-4-hydroxy-2-oxoadipate = oxaloacetate + pyruvate;(R)-4-hydroxy-4-methyl-2-oxoglutarate = pyruvate;l-4-carboxy-4-hydroxy-2-oxoadipate = pyruvate + oxaloacetate" "4-hydroxy-4-methyl-2-oxoglutarate => 2 pyruvate;2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate;2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => oxaloacetate + pyruvate;oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate;NA" "4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate;4-carboxy-4-hydroxy-2-oxoadipate = oxaloacetate + pyruvate;(R)-4-hydroxy-4-methyl-2-oxoglutarate = pyruvate;l-4-carboxy-4-hydroxy-2-oxoadipate = pyruvate + oxaloacetate;oxaloacetate = pyruvate + CO2;2-Oxobutanoate + CO2 <=> Methyloxaloacetate" 5 out of 5 "4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. {ECO:0000269|PubMed:24359411}.; Oxaloacetate = pyruvate + CO(2). {ECO:0000269|PubMed:24359411}." "4-hydroxy-4-methyl-2-oxoglutarate <=> 2 pyruvate; Oxaloacetate <=> pyruvate + CO2" YES "Benzoate degradation; C5-Branched dibasic acid metabolism" pathway from kegg "NA;NA" "Benzoate degradation;path:map00362;C5-Branched dibasic acid metabolism;path:map00660;Microbial metabolism in diverse environments;path:map01120;NA" +116 YER042W "Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease" 1.8.4.11 Methionine-S-sulfoxide reductase Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product. 1.8.4.11 Peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) "MXR1; peptide-methionine-S-sulfoxide reductase" 1.8.4.11 peptide methionine sulfoxide reductase MSRA reduces L-methyl-(S)-S-oxide to L-Methionine "[protein]-L-methionine + [thioredoxin]-disulfide + H2O => [protein]-L-methionine (S)-S-oxide + [thioredoxin]-dithiol;[protein]-L-methionine (S)-S-oxide + [thioredoxin]-dithiol => [protein]-L-methionine + [thioredoxin]-disulfide + H2O" "L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine (S)-S-oxide + Thioredoxin;Peptide-L-methionine + Thioredoxin disulfide + H2O <=> Peptide-L-methionine (S)-S-oxide + Thioredoxin;[protein]-L-methionine + oxidized thioredoxin + H2O = protein-L-methionine-(S)-S-oxide + reduced thioredoxin;calmodulin L-methionine-(S)-sulfoxide + thioredoxin = calmodulin L-methionine + thioredoxin disulfide;dabsyl-L-methionine (S)-sulfoxide + thioredoxin = dabsyl-L-methionine + thioredoxin disulfide + H2O;sulindac + thioredoxin = sulindac sulfide + thioredoxin disulfide + H2O;Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + thioredoxin = Tyr-Gly-Gly-Phe-L-methionine + thioredoxin disulfide + H2O;ribosomal protein L12-L-methionine (S)-sulfoxide + thioredoxin = ribosomal protein L12-L-methionine + thioredoxin disulfide + H2O;peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin;protein-L-methionine (S)-sulfoxide + thioredoxin = protein-L-methionine + thioredoxin disulfide + H2O;Hsp21 L-methionine S-oxide + dithiothreitol = Hsp21 L-methionine + dithiothreitol S-oxide;L-methionine (S)-sulfoxide + 2 dithiothreitol = L-methionine + dithiothreitol disulfide + H2O;L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O" "[protein]-L-methionine + [thioredoxin]-disulfide + H2O => [protein]-L-methionine (S)-S-oxide + [thioredoxin]-dithiol;[protein]-L-methionine (S)-S-oxide + [thioredoxin]-dithiol => [protein]-L-methionine + [thioredoxin]-disulfide + H2O" "L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine (S)-S-oxide + Thioredoxin;Peptide-L-methionine + Thioredoxin disulfide + H2O <=> Peptide-L-methionine (S)-S-oxide + Thioredoxin;[protein]-L-methionine + oxidized thioredoxin + H2O = protein-L-methionine-(S)-S-oxide + reduced thioredoxin;calmodulin L-methionine-(S)-sulfoxide + thioredoxin = calmodulin L-methionine + thioredoxin disulfide;dabsyl-L-methionine (S)-sulfoxide + thioredoxin = dabsyl-L-methionine + thioredoxin disulfide + H2O;sulindac + thioredoxin = sulindac sulfide + thioredoxin disulfide + H2O;Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + thioredoxin = Tyr-Gly-Gly-Phe-L-methionine + thioredoxin disulfide + H2O;ribosomal protein L12-L-methionine (S)-sulfoxide + thioredoxin = ribosomal protein L12-L-methionine + thioredoxin disulfide + H2O;peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin;protein-L-methionine (S)-sulfoxide + thioredoxin = protein-L-methionine + thioredoxin disulfide + H2O;Hsp21 L-methionine S-oxide + dithiothreitol = Hsp21 L-methionine + dithiothreitol S-oxide;L-methionine (S)-sulfoxide + 2 dithiothreitol = L-methionine + dithiothreitol disulfide + H2O;L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O" "a [protein]-L-methionine + an oxidized thioredoxin + H2O = a protein-L-methionine-(R)-S-oxide + a reduced thioredoxin;a [protein]-L-methionine + an oxidized thioredoxin + H2O = a protein-L-methionine-(S)-S-oxide + a reduced thioredoxin" 3 out of 5 "Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin; L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin." L-methionine + thioredoxin disulfide + H(2)O <=> L-methionine (S)-S-oxide + thioredoxin YES Cysteine and methionine metabolism "L-methionine-S-oxide reductase; [c] : metsox-S-L + trdrd --> h2o + met-L + trdox; Methionine Metabolism from e.coli model; it was changed into Cysteine and methionine metabolism based on yeast7.7" "E526;H1252" Protein repair NA "nucleus;cytoplasm" +120 YER087W "Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss" 6.1.1.15 Protein with similarity to tRNA synthetases 6.1.1.15 Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Altered inheritance rate of mitochondria protein 10) (Prolyl-tRNA synthetase) (ProRS) "AIM10; putative proline--tRNA ligase AIM10" 6.1.1.15 Altered Inheritance rate of Mitochondria "L-proline + ATP + tRNA(Pro) => L-prolyl-tRNA(Pro) + AMP + diphosphate;L-prolyl-tRNA(Pro) + AMP + diphosphate => L-proline + ATP + tRNA(Pro)" "ATP + L-Proline + tRNA(Pro) <=> AMP + Diphosphate + L-Prolyl-tRNA(Pro);tRNApro + L-proline + ATP = L-prolyl-[tRNApro] + diphosphate + AMP;ATP + L-proline + tRNAPro = AMP + diphosphate + L-prolyl-tRNAPro;ATP + L-cysteine + tRNAPro = AMP + diphosphate + L-cysteinyl-tRNAPro" "L-proline + ATP + tRNA(Pro) => L-prolyl-tRNA(Pro) + AMP + diphosphate;L-prolyl-tRNA(Pro) + AMP + diphosphate => L-proline + ATP + tRNA(Pro)" "ATP + L-Proline + tRNA(Pro) <=> AMP + Diphosphate + L-Prolyl-tRNA(Pro);tRNApro + L-proline + ATP = L-prolyl-[tRNApro] + diphosphate + AMP;ATP + L-proline + tRNAPro = AMP + diphosphate + L-prolyl-tRNAPro;ATP + L-cysteine + tRNAPro = AMP + diphosphate + L-cysteinyl-tRNAPro" a tRNApro + L-proline + ATP => an L-prolyl-[tRNApro] + AMP + diphosphate ATP + L-Proline + tRNA(Pro) <=> AMP + Diphosphate + L-Prolyl-tRNA(Pro) 3 out of 5 ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). L-proline + ATP + tRNA(Pro) <=> L-prolyl-tRNA(Pro) + AMP + diphosphate YES Aminoacyl-tRNA biosynthesis "pathway from kegg; reaction from rhea" H1017 Aminoacyl-tRNA biosynthesis tRNA charging "Aminoacyl-tRNA biosynthesis;path:map00970" mitochondrion "cytoplasm;mitochondrion" mitochondrion +132 YER141W "Protein required for the hydroxylation of heme O to form heme A; heme A is an essential prosthetic group for cytochrome c oxidase" Protein required for the hydroxylation of heme O to form heme A Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase. {ECO:0000269|PubMed:11248251, ECO:0000269|PubMed:9228094}. Cytochrome c oxidase assembly protein COX15 "COX15; Cox15p" heme a synthase COX15 transforms heme O to heme A ferroheme o + 2 a reduced electron acceptor + 2 oxygen => ferroheme a + 2 an oxidized electron acceptor + 3 H2O Heme O <=> Heme A COX15 transforms heme O to heme A 3 out of 5 NA Heme O <=> Heme A YES Porphyrin and chlorophyll metabolism pathway from kegg "Oxidative phosphorylation;Porphyrin and chlorophyll metabolism;Metabolic pathways;Biosynthesis of secondary metabolites" heme a biosynthesis Heme biosynthesis NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +136 YER163C "Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle" 2.3.2.- Gamma-glutamyl cyclotransferase Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Allows utilization of gluthathione through subsequent cleavage of the Cys-Gly dipeptide by Cys-Gly metallodipeptidase DUG1. {ECO:0000269|PubMed:23070364}. 4.3.2.- Glutathione-specific gamma-glutamylcyclotransferase (Gamma-GCG) (EC 4.3.2.-) "GCG1; gamma-glutamylcyclotransferase" glutathione-specific gamma-glutamylcyclotransferase "CHAC1,2 cleaves GSH to OPRO and CysGly;CHAC1,2 cleaves GSH to OPRO and CysGly" "CHAC1,2 cleaves GSH to OPRO and CysGly;CHAC1,2 cleaves GSH to OPRO and CysGly" 4 out of 5 Glutathione = 5-oxo-L-proline + L-cysteinylglycine. {ECO:0000269|PubMed:23070364}. Glutathione <=> 5-oxo-L-proline + L-cysteinylglycine YES Glutathione metabolism "Glutathione = 5-oxo-L-proline + L-cysteinylglycine; pathway from reactome;. It is changed into Glutathione metabolism" 5-oxo-L-proline metabolism Glutathione synthesis and recycling NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +137 YER166W "Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog, DNF2, that arose from the whole genome duplication" 3.6.3.1 Aminophospholipid translocase (flippase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. {ECO:0000305}. 3.6.3.1 Phospholipid-transporting ATPase DNF1 (EC 3.6.3.1) (Flippase DNF1) "DNF1; aminophospholipid-translocating P4-type ATPase DNF1" 3.6.3.1 Drs2 Neo1 Family "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ YES phospholipids transport pathway from reactome "E586;H449" Ion transport by P-type ATPases NA "cell envelope;cytoplasm;Golgi" "Golgi membrane;mitochondrion;cytoplasm;endoplasmic reticulum;Golgi;cell envelope" "cell envelope;Golgi;cytoplasm" +144 YHL012W "Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication" 2.7.7.9 Putative UTP glucose-1-phosphate uridylyltransferase Plays a central role as a glucosyl donor in cellular metabolic pathways. {ECO:0000250}. 2.7.7.9 Probable UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) UTP--glucose-1-phosphate uridylyltransferase 2.7.7.9 UTP glucose-1-phosphate uridylyltransferase "alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-D-glucose;diphosphate + UDP-D-glucose => alpha-D-glucose 1-phosphate + H(+) + UTP" "UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-alpha-D-galactose;dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose;UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose" "alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-D-glucose;diphosphate + UDP-D-glucose => alpha-D-glucose 1-phosphate + H(+) + UTP" "UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-alpha-D-galactose;dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose;UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose" alpha-D-glucopyranose 1-phosphate + UTP + H+ <=> UDP-alpha-D-glucose + diphosphate UTP + D-Glucose 1-phosphate <=> Diphosphate + UDP-glucose 2 out of 5 UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose. UTP + D-Glucose 1-phosphate <=> Diphosphate + UDP-glucose YES Pentose and glucuronate interconversions pathway from kegg "E341;H733" "dolichyl glucosyl phosphate biosynthesis;glycogen biosynthesis" "Pentose and glucuronate interconversions;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of antibiotics" dolichyl glucosyl phosphate biosynthesis // UDP-glucose biosynthesis "Pentose and glucuronate interconversions;path:map00040;Galactose metabolism;path:map00052;Starch and sucrose metabolism;path:map00500;Amino sugar and nucleotide sugar metabolism;path:map00520;Metabolic pathways;path:map01100;Biosynthesis of antibiotics;path:map01130" cytoplasm +145 YHL018W "Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS" 4.2.1.96 Putative 4a-hydroxytetrahydrobiopterin dehydratase 4.2.1.96 Putative pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydratase) (PCD) 4A-hydroxytetrahydrobiopterin dehydratase 4.2.1.96 Unknown "4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O;(6R)-L-erythro-6,7-dihydrobiopterin + H2O => 4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin" "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O;10-formyltetrahydrofolate-4a-carbinolamine = 10-formyldihydrofolate + H2O;4alpha-hydroxy-tetrahydrobiopterin = 7,8-dihydrobiopterin + H2O" "4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O;(6R)-L-erythro-6,7-dihydrobiopterin + H2O => 4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin" "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O;10-formyltetrahydrofolate-4a-carbinolamine = 10-formyldihydrofolate + H2O;4alpha-hydroxy-tetrahydrobiopterin = 7,8-dihydrobiopterin + H2O" "4alpha-hydroxy-tetrahydrobiopterin = 7,8-dihydrobiopterin + H2O;a 10-formyltetrahydrofolate-4a-carbinolamine = an N10-formyldihydrofolate + H2O" 4a-Hydroxytetrahydrobiopterin <=> Dihydrobiopterin + H2O 2 out of 5 (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O. 4a-Hydroxytetrahydrobiopterin <=> Dihydrobiopterin + H2O YES Folate biosynthesis pathway from kegg H552 Folate biosynthesis "Folate biosynthesis;path:map00790" mitochondrion +148 YHR001W "Oxysterol-binding protein; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication" NA Oxysterol-binding protein Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. {ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206936}. NA Oxysterol-binding protein homolog 7 "OSH7; oxysterol-binding protein related protein OSH7" NA oxysterol-binding protein homolog 7 "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" NA NA NA NA NA NA "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" 5 out of 5 NA "phosphatidylserine <=> phosphatidylserine; phosphatidylinositol 4-phosphate <=> phosphatidylinositol 4-phosphate" YES Lipid transport "Lipid transporter; deliver ps from ER membrane to plasma membrane for the exchanges of phosphatidylinositol 4-phosphate; phosphatidylserine[er] + phosphatidylinositol 4-phosphate[c] => phosphatidylserine[c] + phosphatidylinositol 4-phosphate[er]" NA NA NA NA NA "Acyl chain remodelling of PS;Synthesis of bile acids and bile salts" NA endoplasmic reticulum membrane "cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +150 YHR008C "Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix" 1.15.1.1 Mitochondrial manganese superoxide dismutase Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. 1.15.1.1 Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) "SOD2; superoxide dismutase SOD2" 1.15.1.1 mitochondrial superoxide dismutase "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix);SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2;SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2" "2 H(+) + 2 superoxide => H2O2 + O2;H2O2 + O2 => 2 H(+) + 2 superoxide" 2 superoxide + 2 H+ = O2 + H2O2 "2 H(+) + 2 superoxide => H2O2 + O2;H2O2 + O2 => 2 H(+) + 2 superoxide" 2 superoxide + 2 H+ = O2 + H2O2 2 superoxide + 2 H+ => hydrogen peroxide + oxygen 5 out of 5 2 superoxide + 2 H(+) = O(2) + H(2)O(2). 2 H(+) + 2 superoxide <=> H2O2 + O2 YES Peroxisome "pathway from kegg; reaction from rhea" "E398;H537" removal of superoxide radicals "Peroxisome;Longevity regulating pathway - multiple species" superoxide radicals degradation // ethylene biosynthesis "Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species" NA mitochondrion mitochondrion mitochondrion +156 YHR043C "2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae" 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase Active on 2-DOG-6P, not very active on fructose-1p. 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase 2 (2-DOG-6-P 2) (2-deoxyglucose-6-phosphatase 2) (EC 3.1.3.68) "DOG2; 2-deoxyglucose-6-phosphatase" 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate;2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O" "2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate" "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate;2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O" "2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate" 2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate 3 out of 5 2-deoxy-D-glucose 6-phosphate + H(2)O = 2-deoxy-D-glucose + phosphate. 2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate YES Alternate Carbon Metabolism pathway from e.coli model E695 NA "nucleus;cytoplasm" +157 YHR044C "2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae" 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase Active on 2-DOG-6P, also very active on fructose-1P. 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase 1 (2-DOG-6-P 1) (2-deoxyglucose-6-phosphatase 1) (EC 3.1.3.68) "DOG1; 2-deoxyglucose-6-phosphatase" 3.1.3.68 2-deoxyglucose-6-phosphate phosphatase "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate;2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O" "2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate" "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate;2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O" "2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate" 2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate 3 out of 5 2-deoxy-D-glucose 6-phosphate + H(2)O = 2-deoxy-D-glucose + phosphate. 2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate YES Alternate Carbon Metabolism pathway from e.coli model E695 NA cytoplasm +167 YHR109W "Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth" 2.1.1.59 Cytochrome c lysine methyltransferase Methyltransferase which mediates trimethylation of 'Lys-78' of cytochrome c (CYC1). {ECO:0000269|PubMed:10791961}. 2.1.1.59 Cytochrome c lysine N-methyltransferase 1 (EC 2.1.1.59) "CTM1; cytochrome c lysine N-methyltransferase" 2.1.1.59 cytochrome c methyltransferase "S-adenosyl-L-methionine + [cytochrome c]-L-lysine => S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [cytochrome c]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[cytochrome c]-L-lysine + S-adenosyl-L-methionine = [cytochrome c]-N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+;S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine" "S-adenosyl-L-methionine + [cytochrome c]-L-lysine => S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [cytochrome c]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[cytochrome c]-L-lysine + S-adenosyl-L-methionine = [cytochrome c]-N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+;S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine" a [cytochrome c]-L-lysine + S-adenosyl-L-methionine => a [cytochrome c]-N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+ "Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine" 4 out of 5 S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine. {ECO:0000255|PROSITE-ProRule:PRU00943, ECO:0000269|PubMed:10791961}. S-adenosyl-L-methionine + [cytochrome c]-L-lysine <=> S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine YES Lysine metabolism "pathway from kegg; reaction from uniprot; Lysine degradation was changed into lysine metabolism based on yeast 7.7" Lysine degradation "Lysine degradation;path:map00310" cytoplasm cytoplasm cytoplasm +171 YHR116W "Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs" NA Protein that functions in mitochondrial copper homeostasis Required for the assembly of cytochrome c oxidase. {ECO:0000269|PubMed:15145942}. NA Cytochrome c oxidase-assembly factor COX23, mitochondrial "COX23; Cox23p" NA Cytochrome OXidase NA NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 3 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA NA aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA "cytoplasm;mitochondrial membrane" "cytoplasm;mitochondrion;mitochondrial membrane" "mitochondrial membrane;cytoplasm" +172 YHR119W "Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain" 2.1.1.43 Histone methyltransferase, subunit of the COMPASS (Set1C) complex Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. {ECO:0000269|PubMed:11742990, ECO:0000269|PubMed:11751634, ECO:0000269|PubMed:11752412, ECO:0000269|PubMed:11805083, ECO:0000269|PubMed:11818070, ECO:0000269|PubMed:12060701, ECO:0000269|PubMed:12353038, ECO:0000269|PubMed:12845608, ECO:0000269|PubMed:14636589, ECO:0000269|PubMed:15949446, ECO:0000269|PubMed:9398665, ECO:0000269|PubMed:9988274}. 2.1.1.43 Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC 2.1.1.43) (COMPASS component SET1) (Lysine N-methyltransferase 2) (SET domain-containing protein 1) "SET1, KMT2, YTX1; histone methyltransferase SET1" 2.1.1.43 SET domain-containing SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" a [histone]-L-lysine + S-adenosyl-L-methionine => a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+ "Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine;S-Adenosyl-L-methionine + Histone-L-lysine <=> S-Adenosyl-L-homocysteine + Histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine" 5 out of 5 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. {ECO:0000269|PubMed:11805083}. S-adenosyl-L-methionine + L-lysine-[histone] <=> S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone] YES Lysine metabolism "pathway from kegg; reaction from uniprot; Lysine degradation was changed into lysine metabolism based on yeast 7.7" "H372;H974" Lysine degradation PKMTs methylate histone lysines "Lysine degradation;path:map00310" nucleus nucleus nucleus +174 YHR143W-A "RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress" RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) "RPC10, RPB12; DNA-directed RNA polymerase core subunit RPC10" RNA Polymerase C "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Binding of RRN3 to RNA Polymerase I;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase I Transcription Initiation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus "nucleus;cytoplasm" nucleus +179 YHR179W "Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress" 1.6.99.1 Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) Oxidizes beta-NADH, beta-NADPH, and alpha-NADPH. 1.6.99.1 NADPH dehydrogenase 2 (EC 1.6.99.1) (Old yellow enzyme 2) "OYE2; NADPH dehydrogenase" 1.6.99.1 NAPDH dehydrogenase "NADPH + H+ + acceptor = NADP+ + reduced acceptor;2-cyclohexen-1-one + NADPH + H+ = cyclohexanone + NADP+" "NADPH + H+ + acceptor = NADP+ + reduced acceptor;2-cyclohexen-1-one + NADPH + H+ = cyclohexanone + NADP+" an oxidized electron acceptor + NADPH + H+ = a reduced electron acceptor + NADP+ Acceptor + NADPH + H+ <=> Reduced acceptor + NADP+ 5 out of 5 NADPH + acceptor = NADP(+) + reduced acceptor. Acceptor + NADPH + H+ <=> Reduced acceptor + NADP+ YES other no pathway from database NA "nucleus;cytoplasm;mitochondrion" +180 YHR189W "One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2" 3.1.1.29 One of two mitochondrially-localized peptidyl-tRNA hydrolases 3.1.1.29 Peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29) "PTH1; aminoacyl-tRNA hydrolase" 3.1.1.29 Peptidyl-Trna Hydrolase "N-acyl-L-alpha-aminoacyl-tRNA + H2O => an N-acyl-L-amino acid + H(+) + tRNA;an N-acyl-L-amino acid + H(+) + tRNA => N-acyl-L-alpha-aminoacyl-tRNA + H2O" "N-Substituted aminoacyl-tRNA + H2O <=> N-Substituted amino acid + tRNA;H2O + N-modified aminoacyl-[tRNA] = uncharged tRNA + N-modified amino acid + H+;L-asparaginyl-[tRNAasn] + H2O = L-asparagine + tRNAasn + H+;L-cysteinyl-[tRNAcys] + H2O = L-cysteine + tRNAcys + H+;N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA;diacetyl-lysyl-tRNALys + H2O = diacetyl-lysine + tRNALys;peptidyl-tRNAL + H2O = peptide + tRNA;peptidyl-tRNALys + H2O = peptide + tRNALys;peptidyl-tRNA + H2O = peptide + tRNA" "N-acyl-L-alpha-aminoacyl-tRNA + H2O => an N-acyl-L-amino acid + H(+) + tRNA;an N-acyl-L-amino acid + H(+) + tRNA => N-acyl-L-alpha-aminoacyl-tRNA + H2O" "N-Substituted aminoacyl-tRNA + H2O <=> N-Substituted amino acid + tRNA;H2O + N-modified aminoacyl-[tRNA] = uncharged tRNA + N-modified amino acid + H+;L-asparaginyl-[tRNAasn] + H2O = L-asparagine + tRNAasn + H+;L-cysteinyl-[tRNAcys] + H2O = L-cysteine + tRNAcys + H+;N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA;diacetyl-lysyl-tRNALys + H2O = diacetyl-lysine + tRNALys;peptidyl-tRNAL + H2O = peptide + tRNA;peptidyl-tRNALys + H2O = peptide + tRNALys;peptidyl-tRNA + H2O = peptide + tRNA" "an L-asparaginyl-[tRNAasn] + H2O => L-asparagine + tRNAasn + H+;an N-modified aminoacyl-[tRNA] + H2O => an uncharged tRNA + an N-modified amino acid + H+" 2 out of 5 N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA. N-acyl-L-alpha-aminoacyl-tRNA + H2O <=> an N-acyl-L-amino acid + H(+) + tRNA YES other "no pathway from database; reaction from rhea" H1234 NA mitochondrion mitochondrion mitochondrion +181 YHR201C "Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix" 3.6.1.11 Exopolyphosphatase Degradation of inorganic polyphosphates. 3.6.1.11 Exopolyphosphatase (ExopolyPase) (EC 3.6.1.11) (Metaphosphatase) "PPX1; exopolyphosphatase" 3.6.1.11 exopolyphosphatase "H2O + polyphosphaten => H(+) + phosphate + polyphosphaten-1;H(+) + phosphate + polyphosphaten-1 => H2O + polyphosphaten" "(polyphosphate)n + H2O = (polyphosphate)n-1 + phosphate;guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;inosine tetraphosphate + H2O = ITP + phosphate" "H2O + polyphosphaten => H(+) + phosphate + polyphosphaten-1;H(+) + phosphate + polyphosphaten-1 => H2O + polyphosphaten" "(polyphosphate)n + H2O = (polyphosphate)n-1 + phosphate;guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;inosine tetraphosphate + H2O = ITP + phosphate" (polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate Guanosine 3'-diphosphate 5'-triphosphate + H2O <=> Guanosine 3',5'-bis(diphosphate) + Orthophosphate 4 out of 5 (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate. (polyphosphate)(n) + H2O <=> (polyphosphate)(n-1) + phosphate YES Cofactor and Prosthetic Group Biosynthesis "pathway in kegg is wrong; pathway from e.coli model" E590 Purine metabolism "Purine metabolism;path:map00230" "cytoplasm;mitochondrion;cell envelope" +185 YIL014W "Alpha-1,3-mannosyltransferase; adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation" 2.4.1.- Alpha-1,3-mannosyltransferase Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans. 2.4.1.- Alpha-1,3-mannosyltransferase MNT3 (EC 2.4.1.-) "MNT3; alpha-1,3-mannosyltransferase MNT3" "α-1,3-mannosyltransferase MMN3" "GDP-alpha-D-mannose + an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] => an alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] + GDP + H+;GDP-alpha-D-mannose + an alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] => an alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] + GDP + H+" "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" 3 out of 5 NA "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" YES Other types of O-glycan biosynthesis pathway from kegg "H815;H837;H838;H839" "PATHWAY: Protein modification; protein glycosylation." Other types of O-glycan biosynthesis protein O-mannosylation I (yeast) NA Golgi membrane "Golgi membrane;vacuole;Golgi" Golgi membrane +187 YIL021W "RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit" RNA polymerase II third largest subunit B44 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination. {ECO:0000269|PubMed:16537912}. DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (B44.5) (DNA-directed RNA polymerase II 45 kDa polypeptide) "RPB3; DNA-directed RNA polymerase II core subunit RPB3" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus +188 YIL023C "Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family" Zinc transporter Zinc transporter whose role depends on the zinc status of the cells. It helps to balance zinc levels between the cytosol and the secretory pathway. It transports zinc into the secretory pathway in a zinc-adequate environment and in a high zinc medium. In high zinc medium, transport of zinc into the secretory pathway is a way to eliminate zinc from the cytosol. Under low cytosolic zinc conditions, it removes zinc from the secretory pathway and acts as zinc importer that helps to alleviate ER stress. {ECO:0000269|PubMed:16760462}. Zinc transporter YKE4 "YKE4; Zn(2+) transporter YKE4" Yeast ortholog of mouse KE4 "ZIP6 and ZIP14 mediate zinc influx into cells;ZIP6 and ZIP14 mediate zinc influx into cells;ZIP8 mediates zinc influx into cells;ZIP7 mediates zinc efflux from the endoplasmic reticulum;SLC39A1-4 transports Zn2+ from extracellular region to cytosol" "ZIP6 and ZIP14 mediate zinc influx into cells;ZIP6 and ZIP14 mediate zinc influx into cells;ZIP8 mediates zinc influx into cells;ZIP7 mediates zinc efflux from the endoplasmic reticulum;SLC39A1-4 transports Zn2+ from extracellular region to cytosol" 3 out of 5 NA Zn2+ <=> Zn2+ YES Zinc transport Zinc tranport Zinc influx into cells by the SLC39 gene family NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +193 YIL043C "Cytochrome b reductase; not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia" 1.6.2.2 Cytochrome b reductase Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes. Plays a role in bud morphology. {ECO:0000269|PubMed:10622712}. 1.6.2.2 NADH-cytochrome b5 reductase 1 (EC 1.6.2.2) (Microsomal cytochrome b reductase) (P35) "CBR1, CBR5; Cbr1p" 1.6.2.2 NADH-cytochrome b5 reductase "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme;Surface deployment of platelet alpha granule membrane components;Surface deployment of platelet alpha granule membrane components;Exocytosis of azurophil granule lumen proteins;Exocytosis of azurophil granule lumen proteins;CYB5Rs reduce MetHb to Hb;CYB5Rs reduce MetHb to Hb" "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" 2 a ferricytochrome b5 + NADH => 2 a ferrocytochrome b5 + NAD+ + H+ NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme;CYB5Rs reduce MetHb to Hb;CYB5Rs reduce MetHb to Hb" 5 out of 5 NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5. NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ YES Amino sugar and nucleotide sugar metabolism pathway from kegg H588 Amino sugar and nucleotide sugar metabolism "Platelet degranulation ;Erythrocytes take up carbon dioxide and release oxygen;Vitamin C (ascorbate) metabolism;Neutrophil degranulation" "Amino sugar and nucleotide sugar metabolism;path:map00520" "endoplasmic reticulum membrane;mitochondrial membrane" "nucleus;mitochondrion;mitochondrial membrane;endoplasmic reticulum;endoplasmic reticulum membrane" "mitochondrial membrane;endoplasmic reticulum membrane" +194 YIL048W "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ YES phospholipids transport "E586;H449" NA "cytoplasm;Golgi membrane" "Golgi membrane;cytoplasm;Golgi;cell envelope" "Golgi membrane;cytoplasm" +195 YIL049W "Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human homolog SRD5A3 confer CDG (Congenital Disorders of Glycosylation); human SRD5A3 can complement yeast null mutant" 1.3.1.94 Probable polyprenol reductase Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. {ECO:0000269|PubMed:20637498}. 1.3.1.94 Polyprenol reductase (EC 1.3.1.94) (Protein DFG10) "DFG10; putative polyprenol reductase" "1.3.1.22;1.3.1.94" polyprenol reductase "di-trans,poly-cis-dolichol + NADP(+) => di-trans,poly-cis-polyprenol + H(+) + NADPH;di-trans,poly-cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)" ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH + H+ "di-trans,poly-cis-dolichol + NADP(+) => di-trans,poly-cis-polyprenol + H(+) + NADPH;di-trans,poly-cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)" ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH + H+ a di-trans, poly-cis-polyprenol + NADPH + H+ => a dolichol + NADP+ "5alpha-Pregnane-3,20-dione + NADP+ <=> Progesterone + NADPH + H+;Dihydrotestosterone + NADP+ <=> Testosterone + NADPH + H+;11-Deoxycorticosterone + NADPH + H+ <=> 5alpha-Dihydrodeoxycorticosterone + NADP+;5alpha-Androstane-3,17-dione + NADP+ <=> Androstenedione + NADPH + H+" 5 out of 5 Ditrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH. {ECO:0000269|PubMed:20637498}. a di-trans, poly-cis-polyprenol + NADPH + H+ => a dolichol + NADP+ YES dolichol and dolichyl phosphate biosynthesis pathway from biocyc "PATHWAY: Protein modification; protein glycosylation." dolichol and dolichyl phosphate biosynthesis NA endoplasmic reticulum membrane "cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +211 YIR008C "Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair" 2.7.7.- Subunit of DNA primase DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48. 2.7.7.- DNA primase small subunit (EC 2.7.7.-) (DNA polymerase alpha:primase complex p48 subunit) (DNA polymerase-primase complex p48 subunit) (Pol alpha-primase complex p48 subunit) (DNA primase 48 kDa subunit) "PRI1; DNA primase subunit PRI1" NA DNA PRImase "Detection of damage during initiation of DNA synthesis in S-phase;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere;RFC binding displaces Pol Alpha on the C-strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin;RFC binding displaces Pol Alpha;Loading of PCNA - Sliding Clamp Formation;RFC dissociates after sliding clamp formation;Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" NA NA NA NA a single stranded DNA = a short RNA Segment "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" NA 5 out of 5 NA 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA primase is required for DNA synthesis and double-strand break repair NA NA NA "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication" NA "Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand" NA nucleus +216 YIR036C "Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci" 1.1.1.320 Putative benzil reductase Reduces benzil stereospecifically to (S)-benzoin. Is probably involved in a pathway contributing to genomic integrity. 1.1.1.320 Benzil reductase ((S)-benzoin forming) IRC24 (EC 1.1.1.320) (Increased recombination centers protein 24) "IRC24; sepiapterin reductase family protein IRC24" 1.1.1.320 Increased Recombination Centers "PTHP is reduced to BH4 by sepiapterin reductase (SPR);Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II;Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II;Salvage - Sepiapterin is reduced to BH2" "(S)-benzoin + NADP(+) => benzil + H(+) + NADPH;benzil + H(+) + NADPH => (S)-benzoin + NADP(+);2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH;1-phenyl-1,2-propanedione + H(+) + NADPH => 2-hydroxy-1-phenyl-1-propanone + NADP(+)" "(S)-benzoin + NADP+ = benzil + NADPH + H+;2-hydroxy-1-phenyl-1-propanone + NADP+ = 1-phenylpropane-1,2-dione + NADPH + H+" "(S)-benzoin + NADP(+) => benzil + H(+) + NADPH;benzil + H(+) + NADPH => (S)-benzoin + NADP(+);2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH;1-phenyl-1,2-propanedione + H(+) + NADPH => 2-hydroxy-1-phenyl-1-propanone + NADP(+)" "(S)-benzoin + NADP+ = benzil + NADPH + H+;2-hydroxy-1-phenyl-1-propanone + NADP+ = 1-phenylpropane-1,2-dione + NADPH + H+" NA NA "PTHP is reduced to BH4 by sepiapterin reductase (SPR);Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II;Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II;Salvage - Sepiapterin is reduced to BH2" 4 out of 5 (S)-benzoin + NADP(+) = benzil + NADPH. {ECO:0000269|PubMed:11796169}. (S)-benzoin + NADP(+) = benzil + NADPH YES Other NA NA NA NA NA NA Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation NA cytoplasm +217 YIR038C "ER associated glutathione S-transferase; capable of homodimerization; glutathione transferase for Yvc1p vacuolar cation channel; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p" 2.5.1.18 ER associated glutathione S-transferase 2.5.1.18 Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) "GTT1; bifunctional glutathione transferase/peroxidase" 2.5.1.18 glutathione transferase "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+;glutathione + 4-hydroxy-2-nonenal = 4-hydroxy-2-nonenal-glutathione conjugate;glutathione + RX = a glutathione-toxin conjugate + HX" "RX + Glutathione <=> Halide + R-S-Glutathione;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH" 4 out of 5 RX + glutathione = HX + R-S-glutathione. RX + glutathione = HX + R-S-glutathione YES Glutathione metabolism "pathway from kegg; reaction from uniprot" "H675;H1101" glutathione-glutaredoxin redox reactions Glutathione metabolism "Glutathione metabolism;path:map00480;Metabolism of xenobiotics by cytochrome P450;path:map00980;Drug metabolism - cytochrome P450;path:map00982" endoplasmic reticulum membrane "nucleus;mitochondrion;mitochondrial membrane;endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" endoplasmic reticulum membrane +222 YKL045W "Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair" 2.7.7.- Subunit of DNA primase DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48. 2.7.7.- DNA primase large subunit (EC 2.7.7.-) (DNA polymerase alpha:primase complex p58 subunit) (DNA polymerase-primase complex p58 subunit) (Pol alpha-primase complex p58 subunit) (DNA primase 58 kDa subunit) "PRI2; DNA primase subunit PRI2" NA DNA PRImase "Detection of damage during initiation of DNA synthesis in S-phase;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere;RFC binding displaces Pol Alpha on the C-strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin;RFC binding displaces Pol Alpha;Loading of PCNA - Sliding Clamp Formation;RFC dissociates after sliding clamp formation;Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" NA NA NA NA a single stranded DNA = a short RNA Segment "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" NA 5 out of 5 NA 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA primase is required for DNA synthesis and double-strand break repair NA NA NA "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication" NA "Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand" NA nucleus +225 YKL069W "Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress" 1.8.4.14 Methionine-R-sulfoxide reductase Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Does not act on S-enantiomer of free methionine sulfoxide or R-enantiomer of dabsylated methionine sulfoxide. Involved in protection against oxidative stress. {ECO:0000269|PubMed:19049972}. 1.8.4.14 Free methionine-R-sulfoxide reductase (fRMsr) (EC 1.8.4.14) (GAF domain-containing protein YKL069W) "YKG9; L-methionine (R)-S-oxide reductase" 1.8.4.14 YKL069W "[thioredoxin]-disulfide + L-methionine + H2O => [thioredoxin]-dithiol + L-methionine (R)-S-oxide;[thioredoxin]-dithiol + L-methionine (R)-S-oxide => [thioredoxin]-disulfide + L-methionine + H2O" "L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine (R)-S-oxide + Thioredoxin;L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin" "[thioredoxin]-disulfide + L-methionine + H2O => [thioredoxin]-dithiol + L-methionine (R)-S-oxide;[thioredoxin]-dithiol + L-methionine (R)-S-oxide => [thioredoxin]-disulfide + L-methionine + H2O" "L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine (R)-S-oxide + Thioredoxin;L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin" L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin 5 out of 5 L-methionine + thioredoxin disulfide + H(2)O = L-methionine (R)-S-oxide + thioredoxin. {ECO:0000269|PubMed:19049972}. L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin YES Cysteine and methionine metabolism pathway from kegg E526 Cysteine and methionine metabolism "Cysteine and methionine metabolism;path:map00270" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +229 YKL087C "Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant" 4.4.1.- Cytochrome c1 heme lyase Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein. 4.4.1.- Cytochrome c1 heme lyase (CC1HL) (EC 4.4.1.-) "CYT2; cytochrome c1 heme lyase CYT2" 4.4.1.17 cytochrome c1 heme lyase a c-type cytochrome <=> heme c + an apo-[c-type cytochrome] Cytochrome c <=> Apocytochrome c + Heme 3 out of 5 NA Cytochrome c <=> Apocytochrome c + Heme YES Porphyrin and chlorophyll metabolism pathway from kegg Porphyrin and chlorophyll metabolism NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +231 YKL103C "Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress" 3.4.11.22 Vacuolar aminopeptidase yscI Resident vacuolar enzyme that catalyzes the removal of amino acids from the N-terminus of peptides and proteins. Also acts as the major cargo protein of the cytoplasm-to-vacuole targeting (Cvt) pathway. The precursor form of aminopeptidase 1 (prApe1) assembles into dodecamers and the propeptide mediates the aggregation of dodecamers into higher multimers. The multimers are then recognized via the propeptide by their receptor ATG19, and ATG19 further interacts with ATG11, which tethers the APE1-ATG19 complex to the pre-autophagosomal structure (PAS). The cargo-receptor complex (also Cvt complex) is selectively enwrapped by a double-membrane structure termed the Cvt vesicle under vegetative growth conditions and by a similar but larger double-membrane structure termed the autophagosome under nitrogen starvation conditions. The Cvt vesicle or the autophagosome fuses with the vacuolar membrane and release its content in the vacuolar lumen. In the vacuole, prApe1 is processed into mature aminopeptidase 1 (mApe1). {ECO:0000269|PubMed:11382752, ECO:0000269|PubMed:11430817, ECO:0000269|PubMed:15138258, ECO:0000269|PubMed:22123825, ECO:0000269|PubMed:363165, ECO:0000269|PubMed:8901576, ECO:0000269|PubMed:9214379, ECO:0000269|PubMed:9412464}. 3.4.11.22 Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I) "APE1, API, LAP4, YSC1; metalloaminopeptidase APE1" 3.4.11.22 vacuolar aminopeptidase ysc1 "L-Ala-Gly + H2O = L-Ala + Gly;L-Ala-L-Leu + H2O = L-Ala + L-Leu" "L-Ala-Gly + H2O = L-Ala + Gly;L-Ala-L-Leu + H2O = L-Ala + L-Leu" a protein + H2O => a proteinogenic amino acid + a peptide 5 out of 5 Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates. {ECO:0000269|PubMed:19185714, ECO:0000269|PubMed:363165, ECO:0000269|PubMed:3890752, ECO:0000269|PubMed:5147, ECO:0000269|PubMed:6352682}. "L-Ala-Gly + H2O <=> L-Ala + Gly;L-Ala-L-Leu + H2O <=> L-Ala + L-Leu" YES Hydrolysis of peptide bond no pathway from database NA vacuole "vacuole;extracellular;cytoplasm" vacuole +238 YKL144C "RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p" RNA polymerase III subunit C25 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation. DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III 25 kDa polypeptide) (RNA polymerase III subunit C25) "RPC25, YKL1; DNA-directed RNA polymerase III subunit RPC25" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus +239 YKL150W "Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis" 1.6.2.2 Mitochondrial NADH-cytochrome b5 reductase The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals. {ECO:0000269|PubMed:11420140}. 1.6.2.2 "NADH-cytochrome b5 reductase 2 (EC 1.6.2.2) (Mitochondrial cytochrome b reductase) (p34/p32) [Cleaved into: NADH-cytochrome b5 reductase p34 form; NADH-cytochrome b5 reductase p32 form]" "MCR1; cytochrome-b5 reductase" 1.6.2.2 NADH-cytochrome b5 reductase CYB5Rs reduce MetHb to Hb "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" "2 a ferricytochrome b5 + NADH => 2 a ferrocytochrome b5 + NAD+ + H+;2 a ferrihemoglobin + NADH = 2 a ferrohemoglobin + NAD+ + H+" NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ CYB5Rs reduce MetHb to Hb 5 out of 5 NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5. NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ YES Amino sugar and nucleotide sugar metabolism pathway from kegg H588 Amino sugar and nucleotide sugar metabolism Erythrocytes take up carbon dioxide and release oxygen "Amino sugar and nucleotide sugar metabolism;path:map00520" mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +253 YKL215C "5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress" 3.5.2.9 5-oxoprolinase Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. {ECO:0000269|PubMed:20349993, ECO:0000269|PubMed:20402795}. 3.5.2.9 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase) "OXP1; 5-oxoprolinase" 3.5.2.9 5-oxoprolinase (ATP-hydrolysing) OPLAH hydrolyses OPRO to L-Glu "5-oxo-L-proline + ATP + 2 H2O => L-glutamate + ADP + H(+) + phosphate;L-glutamate + ADP + H(+) + phosphate => 5-oxo-L-proline + ATP + 2 H2O" ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate "5-oxo-L-proline + ATP + 2 H2O => L-glutamate + ADP + H(+) + phosphate;L-glutamate + ADP + H(+) + phosphate => 5-oxo-L-proline + ATP + 2 H2O" ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate 5-oxo-L-proline + ATP + 2 H2O => L-glutamate + ADP + phosphate + H+ ATP + Pidolic acid + 2 H2O <=> ADP + Orthophosphate + L-Glutamate OPLAH hydrolyses OPRO to L-Glu 5 out of 5 ATP + 5-oxo-L-proline + 2 H(2)O = ADP + phosphate + L-glutamate. 5-oxo-L-proline + ATP + 2 H2O => L-glutamate + ADP + phosphate + H+ YES Glutathione metabolism pathway from kegg H436 Glutathione metabolism "γ-glutamyl cycle // 5-oxo-L-proline metabolism" Glutathione synthesis and recycling "Glutathione metabolism;path:map00480" cytoplasm cytoplasm cytoplasm +254 YKL218C "3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity" 4.3.1.16 3-hydroxyaspartate dehydratase Catalyzes the deamination of L-threo-3-hydroxyaspartate to oxaloacetate and ammonia. Shows a high specificity towards L-threo-3-hydroxyaspartate as other 3-hydroxyaminoacids, i.e. D,L-erythro- and D-threo-3-hydroxyaspartate, D-threonine, L-threonine, D,L-allothreonine, D-serine, and L-serine, are not substrates for this enzyme. Exhibits no detectable serine racemase activity. Is responsible for the 3-hydroxyaspartate resistance of S.cerevisiae, and thus may be involved in the detoxification of naturally occurring 3-hydroxyaspartate. {ECO:0000269|PubMed:12951240}. 4.3.1.16 L-threo-3-hydroxyaspartate ammonia-lyase (EC 4.3.1.16) (L-threo-3-hydroxyaspartate dehydratase) "SRY1; threo-3-hydroxy-L-aspartate ammonia-lyase SRY1" NA Serine Racemase NA "(3S)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate;NH4(+) + oxaloacetate => (3S)-3-hydroxy-L-aspartate" threo-3-hydroxy-L-aspartate = oxaloacetate + NH3 "(3S)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate;NH4(+) + oxaloacetate => (3S)-3-hydroxy-L-aspartate" threo-3-hydroxy-L-aspartate = oxaloacetate + NH3 (3S)-3-hydroxy-L-aspartate = oxaloacetate + ammonium NA NA 5 out of 5 Threo-3-hydroxy-L-aspartate = oxaloacetate + NH(3). {ECO:0000269|PubMed:12951240}. Threo-3-hydroxy-L-aspartate = oxaloacetate + NH(3) YES Other NA NA NA NA NA NA NA NA cytoplasm +255 YKL220C "Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels" 1.16.1.9 Ferric reductase and cupric reductase Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake. {ECO:0000269|PubMed:11120744, ECO:0000269|PubMed:9153234}. 1.16.1.9 Ferric/cupric reductase transmembrane component 2 (EC 1.16.1.9) (Ferric-chelate reductase 2) "FRE2; ferric/cupric-chelate reductase" ferric reductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+;2 an Fe(III)-siderophore + NADPH => 2 Fe2+ + 2 a siderophore + NADP+ + H+;2 ferric (2,3-dihydroxybenzoylserine)3 + NADPH + 9 H+ => 2 Fe2+ + 2 (2,3-dihydroxybenzoylserine)3 + NADP+" 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope "vacuole;cell envelope" cell envelope +256 YKR002W "Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping" 2.7.7.19 Poly(A) polymerase Polymerase component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. {ECO:0000269|PubMed:17850751, ECO:0000269|PubMed:18537269}. 2.7.7.19 Poly(A) polymerase (PAP) (EC 2.7.7.19) (Polynucleotide adenylyltransferase) "PAP1; polynucleotide adenylyltransferase PAP1" 2.7.7.19 Poly(A) Polymerase NA "ATP + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => ATP + RNAn" "ATP + RNA <=> Diphosphate + RNA;ATP + mRNA = diphosphate + mRNA;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+3'-A;ATP + RNA = diphosphate + RNA(A)n" "ATP + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => ATP + RNAn" "ATP + RNA <=> Diphosphate + RNA;ATP + mRNA = diphosphate + mRNA;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+3'-A;ATP + RNA = diphosphate + RNA(A)n" ATP + an mRNA = an mRNA + diphosphate NA NA 5 out of 5 ATP + RNA(n) = diphosphate + RNA(n+1). {ECO:0000269|PubMed:17850751, ECO:0000269|PubMed:18537269}. ATP + RNA(n) <=> diphosphate + RNA(n+1) YES mRNA surveillance pathway RNA synthesis H1118 NA NA mRNA surveillance pathway NA NA NA nucleus nucleus nucleus +257 YKR003W "Member of an oxysterol-binding protein family; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion; OSH6 has a paralog, OSH7, that arose from the whole genome duplication" NA Member of an oxysterol-binding protein family Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum (PubMed:23934110, PubMed:26206936). Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206936). {ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206936}. NA Oxysterol-binding protein homolog 6 "OSH6; oxysterol-binding protein OSH6" NA OxySterol binding protein Homolog "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" NA NA NA NA NA NA "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane;OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" 5 out of 5 NA "phosphatidylserine <=> phosphatidylserine; phosphatidylinositol 4-phosphate <=> phosphatidylinositol 4-phosphate" YES Lipid transport "Lipid transporter; deliver ps from ER membrane to plasma membrane for the exchanges of phosphatidylinositol 4-phosphate; phosphatidylserine[er] + phosphatidylinositol 4-phosphate[c] => phosphatidylserine[c] + phosphatidylinositol 4-phosphate[c]" NA NA NA NA NA "Acyl chain remodelling of PS;Synthesis of bile acids and bile salts" NA endoplasmic reticulum membrane "cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +259 YKR025W RNA polymerase III subunit C37 RNA polymerase III subunit C37 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation. {ECO:0000269|PubMed:16362040}. DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 37 kDa polypeptide) (RNA polymerase III subunit C37) "RPC37; DNA-directed RNA polymerase III subunit C37" RNA Polymerase C a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 3 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;RNA polymerase" NA nucleus nucleus nucleus +263 YKR076W "S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm" "1.8.5.1;2.5.1.18" S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis. {ECO:0000269|PubMed:16709151}. "2.5.1.18; 1.8.5.1" Glutathione S-transferase omega-like 2 (EC 2.5.1.18) (Extracellular mutant protein 4) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) "ECM4, GTO2; S-glutathionyl-(chloro)hydroquinone reductase" 1.8.5.7 ExtraCellular Mutant "L-dehydroascorbate + 2 glutathione => L-ascorbate + glutathione disulfide;L-ascorbate + glutathione disulfide => L-dehydroascorbate + 2 glutathione;glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate;5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione;L-dehydroascorbate + 2 glutathione => L-ascorbate + glutathione disulfide;L-ascorbate + glutathione disulfide => L-dehydroascorbate + 2 glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin;2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate" "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+;glutathione + 4-hydroxy-2-nonenal = 4-hydroxy-2-nonenal-glutathione conjugate;glutathione + RX = a glutathione-toxin conjugate + HX" 5 out of 5 "RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:16709151}.; 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate. {ECO:0000269|PubMed:16709151}." "RX + glutathione = HX + R-S-glutathione;2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate" YES Glutathione metabolism "pathway from kegg; reaction from uniprot" "H675;H1101;NA" "Glutathione metabolism;path:map00480;Metabolism of xenobiotics by cytochrome P450;path:map00980;Drug metabolism - cytochrome P450;path:map00982;NA" cytoplasm cytoplasm cytoplasm +266 YKR093W "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" Integral membrane peptide transporter Uptake of small peptides. Peptide transporter PTR2 (Peptide permease PTR2) "PTR2; Ptr2p" Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport" 4 out of 5 NA "di- peptide <=> di- peptide; tri-peptide <=> tri-peptide" YES peptide transport Uptake of small peptides. "Proton/oligopeptide cotransporters;Neutrophil degranulation" NA "vacuole;cell envelope" +269 YFL061W "Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p" 4.2.1.69 Cyanamide hydratase that detoxifies cyanamide Cyanamide hydratase involved in the detoxification and/or utilization of cyanamide, a toxic nitrile compound distributed widely in the environment. {ECO:0000269|PubMed:25847245}. 4.2.1.69 Cyanamide hydratase DDI2 (CAH) (EC 4.2.1.69) (DNA damage-inducible protein 2) "DDI2; cyanamide hydratase" 4.2.1.69 DNA Damage Inducible "urea => cyanamide + H2O;cyanamide + H2O => urea" urea = cyanamide + H2O "urea => cyanamide + H2O;cyanamide + H2O => urea" urea = cyanamide + H2O Urea <=> Cyanamide + H2O 4 out of 5 Urea = cyanamide + H(2)O. {ECO:0000269|PubMed:25847245}. Urea <=> Cyanamide + H2O YES Atrazine degradation pathway from kegg Atrazine degradation "Atrazine degradation;path:map00791;Microbial metabolism in diverse environments;path:map01120" +270 YFL060C "Protein of unknown function; nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin" "3.5.1.2;4.3.3.6" Protein of unknown function Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform. {ECO:0000250|UniProtKB:Q03144, ECO:0000269|PubMed:12271461}. "4.3.3.6; 3.5.1.2" Probable pyridoxal 5'-phosphate synthase subunit SNO3 (EC 4.3.3.6) (PDX2 homolog 3) (Pdx2.3) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) "SNO3; putative pyridoxal 5'-phosphate synthase" 4.3.3.6 SNZ proximal Open reading frame "L-glutamine + H2O => L-glutamate + NH4(+);L-glutamate + NH4(+) => L-glutamine + H2O;aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-glutamine + H2O = D-glutamate + NH3;a monocarboxylic acid amide + H2O = a monocarboxylate + NH3;L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine;L-glutamine + H2O => L-glutamate + NH4(+);L-glutamate + NH4(+) => L-glutamine + H2O" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+;L-glutamine + H2O = L-glutamate + NH3;D-glutamine + H2O = D-glutamate + NH3;a monocarboxylic acid amide + H2O = a monocarboxylate + NH3" D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O 4 out of 5 "D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate. {ECO:0000250|UniProtKB:Q03144}.; L-glutamine + H(2)O = L-glutamate + NH(3). {ECO:0000250|UniProtKB:Q03144}." "L-glutamine + H2O => L-glutamate + NH4(+);aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate" YES Vitamin B6 metabolism "pathway from kegg; reaction from rhea" "NA;NA" "PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. {ECO:0000250|UniProtKB:Q03144}." Vitamin B6 metabolism "Vitamin B6 metabolism;path:map00750;NA" cytoplasm +271 YFL059W "Member of a stationary phase-induced gene family; expressed in the presence of galactose; transcription of SNZ3 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3" 4.3.3.6 Member of a stationary phase-induced gene family Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. {ECO:0000250|UniProtKB:Q03148}. 4.3.3.6 Probable pyridoxal 5'-phosphate synthase subunit SNZ3 (PLP synthase subunit SNZ3) (EC 4.3.3.6) (PDX1 homolog 3) (Pdx1.3) "SNZ3; pyridoxine biosynthesis protein SNZ3" 4.3.3.6 SNooZe "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O 3 out of 5 D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate. {ECO:0000250|UniProtKB:Q03148}. D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O YES Vitamin B6 metabolism pathway from kegg "PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis." Vitamin B6 metabolism "Vitamin B6 metabolism;path:map00750" +272 YFL058W "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" Protein involved in synthesis of the thiamine precursor HMP Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. {ECO:0000269|PubMed:23048037}. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5 (HMP-P synthase) (Hydroxymethylpyrimidine phosphate synthase) (Thiamine biosynthesis protein 5) (Thiamine pyrimidine synthase) "THI5; 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" MONOMER3O-3915 [an HMP-P synthase]-L-histidine + pyridoxal 5'-phosphate => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + an HMP-P synthase Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine 5 out of 5 NA Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine YES Thiamine metabolism pathway from kegg thiamine biosynthesis "PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000305|PubMed:12777485}." "Thiamine metabolism;Metabolic pathways" superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis NA +273 YFL054C "Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol" Putative channel-like protein Uncharacterized membrane protein YFL054C "AQY3; Aqy3p" YFL054C "Aquaporin-9 passively transports glycerol into cell;Aquaporin-7 passively transports glycerol out of cell;Aquaporin-3 passively transports water out of cell;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport urea out of cells;Aquaporins passively transport urea out of cells;Aquaporins passively transport urea into cells;Aquaporins passively transport urea into cells" "Aquaporin-9 passively transports glycerol into cell;Aquaporin-7 passively transports glycerol out of cell;Aquaporin-3 passively transports water out of cell;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport glycerol into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport glycerol out of cells;Aquaporins passively transport urea out of cells;Aquaporins passively transport urea out of cells;Aquaporins passively transport urea into cells;Aquaporins passively transport urea into cells" 3 out of 5 NA glycerol <=> glycerol YES glycerol transport glycerol "Transport of glycerol from adipocytes to the liver by Aquaporins;Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins" NA cell envelope +275 YFL036W "Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Rpo41p also synthesizes RNA primers for mitochondrial DNA replication" 2.7.7.6 Mitochondrial RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. 2.7.7.6 DNA-directed RNA polymerase, mitochondrial (EC 2.7.7.6) "RPO41; DNA-directed RNA polymerase" 2.7.7.6 RNA POlymerase "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). {ECO:0000255|PROSITE-ProRule:PRU10031, ECO:0000255|PROSITE-ProRule:PRU10032}. 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase Mitochondrial RNA polymerase H1118 "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" mitochondrion "cytoplasm;mitochondrion" mitochondrion +284 YFR044C "Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant" 3.4.13.- Cys-Gly metallo-di-peptidase Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides. {ECO:0000269|PubMed:17179087, ECO:0000269|PubMed:19346245}. 3.4.13.- Cys-Gly metallodipeptidase DUG1 (EC 3.4.13.-) (Deficient in utilization of glutathione protein 1) (GSH degradosomal complex subunit DUG1) "DUG1; metallodipeptidase" MONOMER3O-4 CNDP2:2Mn2+ dimer hydrolyses CysGly L-cysteinyl-glycine + H2O => L-cysteine + glycine "Cys-Gly + H2O <=> L-Cysteine + Glycine;R-S-Cysteinylglycine + H2O <=> S-Substituted L-cysteine + Glycine" CNDP2:2Mn2+ dimer hydrolyses CysGly 5 out of 5 NA "Cys-Gly + H2O <=> L-Cysteine + Glycine;R-S-Cysteinylglycine + H2O <=> S-Substituted L-cysteine + Glycine" YES cysteine and methionine metabolism pathway from E.coli model. Cysteine metabolism was changed into cysteine and methionine metabolism based on yeast 7.7 E528 "superpathway of glutathione metabolism (truncated gamma-glutamyl cycle);glutathione degradation" "Glutathione metabolism;Metabolic pathways" "superpathway of glutathione metabolism (truncated γ-glutamyl cycle) // glutathione degradation // γ-glutamyl cycle // glutathione degradation (DUG pathway)" Glutathione synthesis and recycling NA cytoplasm "cytoplasm;mitochondrion" cytoplasm +286 YFR055W "Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner" 4.4.1.8 Beta-lyase involved in the production of thiols 4.4.1.8 Putative cystathionine beta-lyase (CBL) (EC 4.4.1.8) (Beta-cystathionase) (Cysteine lyase) (Increased recombination centers protein 7) "IRC7; cysteine-S-conjugate beta-lyase IRC7" 4.4.1.8 cystathionine beta-lyase "L-cystathionine + H2O => L-homocysteine + NH4(+) + pyruvate;L-homocysteine + NH4(+) + pyruvate => L-cystathionine + H2O" "2-aminoprop-2-enoate = 2-iminopropanoate;2-iminopropanoate + H2O = pyruvate + NH3;L-cysteine + H2O = sulfide + NH3 + pyruvate;L-cystathionine = L-homocysteine + 2-aminoprop-2-enoate;L-cystathionine + H2O = L-homocysteine + pyruvate + NH3;L-cystine + H2O = L-thiocysteine + pyruvate + NH3;L-Selenocystathionine + H2O <=> Selenohomocysteine + Ammonia + Pyruvate" "L-cystathionine + H2O => L-homocysteine + NH4(+) + pyruvate;L-homocysteine + NH4(+) + pyruvate => L-cystathionine + H2O" "2-aminoprop-2-enoate = 2-iminopropanoate;2-iminopropanoate + H2O = pyruvate + NH3;L-cysteine + H2O = sulfide + NH3 + pyruvate;L-cystathionine = L-homocysteine + 2-aminoprop-2-enoate;L-cystathionine + H2O = L-homocysteine + pyruvate + NH3;L-cystine + H2O = L-thiocysteine + pyruvate + NH3;L-Selenocystathionine + H2O <=> Selenohomocysteine + Ammonia + Pyruvate" "L-cystathionine + H2O => ammonium + pyruvate + L-homocysteine;L-selenocystathionine + H2O = ammonium + pyruvate + seleno-L-homocysteine" "L-Cysteine + H2O <=> Hydrogen sulfide + Pyruvate + Ammonia;L-Cystathionine + H2O <=> L-Homocysteine + Ammonia + Pyruvate;L-Cystine + H2O <=> Pyruvate + Ammonia + Thiocysteine;L-Selenocystathionine + H2O <=> Selenohomocysteine + Ammonia + Pyruvate" 4 out of 5 L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate. L-cystathionine + H2O <=> L-homocysteine + NH4(+) + pyruvate YES Cysteine and methionine metabolism "pathway from kegg; reaction from uniprot; reaction from rhea" "E83;E469" "PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1." "Cysteine and methionine metabolism;Selenocompound metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of amino acids" superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) // cysteine biosynthesis IV (fungi) // homocysteine and cysteine interconversion "Cysteine and methionine metabolism;path:map00270;Selenocompound metabolism;path:map00450;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" cytoplasm +292 YDL021W "Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM2 has a paralog, GPM3, that arose from the whole genome duplication" 5.4.2.11 Homolog of Gpm1p phosphoglycerate mutase Could be non-functional. 5.4.2.11 Phosphoglycerate mutase 2 (PGAM 2) (EC 5.4.2.11) (BPG-dependent PGAM 2) (MPGM 2) (Phosphoglyceromutase 2) "GPM2; phosphoglycerate mutase family protein GPM2" 5.4.2.11 Glycerate PhosphoMutase "2-phospho-D-glycerate => 3-phospho-D-glycerate;3-phospho-D-glycerate => 2-phospho-D-glycerate;2,3-bisphospho-D-glycerate + H2O => 3-phospho-D-glycerate + phosphate;3-phospho-D-glycerate + phosphate => 2,3-bisphospho-D-glycerate + H2O" "2-phospho-D-glycerate = 3-phospho-D-glycerate;2,3-Bisphospho-D-glycerate + Protein histidine <=> 3-Phospho-D-glycerate + Protein N(tau)-phospho-L-histidine;[enzyme]-Ntau-phospho-L-histidine + 2/3-bisphospho-D-glycerate = [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate;[enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-Ntau-phospho-L-histidine + 3-phospho-D-glycerate;[enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-Ntau-phospho-L-histidine + 2/3-phospho-D-glycerate;2-phospho-D-glycerate + 2,3-bisphosphoglycerate = 3-phospho-D-glycerate + 2,3-bisphosphoglycerate;[enzyme]-Ntau-phospho-L-histidine + 2-phospho-D-glycerate = [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate" "2-phospho-D-glycerate => 3-phospho-D-glycerate;3-phospho-D-glycerate => 2-phospho-D-glycerate;2,3-bisphospho-D-glycerate + H2O => 3-phospho-D-glycerate + phosphate;3-phospho-D-glycerate + phosphate => 2,3-bisphospho-D-glycerate + H2O" "2-phospho-D-glycerate = 3-phospho-D-glycerate;2,3-Bisphospho-D-glycerate + Protein histidine <=> 3-Phospho-D-glycerate + Protein N(tau)-phospho-L-histidine;[enzyme]-Ntau-phospho-L-histidine + 2/3-bisphospho-D-glycerate = [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate;[enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-Ntau-phospho-L-histidine + 3-phospho-D-glycerate;[enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-Ntau-phospho-L-histidine + 2/3-phospho-D-glycerate;2-phospho-D-glycerate + 2,3-bisphosphoglycerate = 3-phospho-D-glycerate + 2,3-bisphosphoglycerate;[enzyme]-Ntau-phospho-L-histidine + 2-phospho-D-glycerate = [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate" 2-phospho-D-glycerate <=> 3-phospho-D-glycerate 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate 4 out of 5 2-phospho-D-glycerate = 3-phospho-D-glycerate. 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate YES Glycolysis / Gluconeogenesis Could be non-functional. Pathway from kegg E632 "PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5." "Glycolysis / Gluconeogenesis;Glycine, serine and threonine metabolism;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids" gluconeogenesis // glycolysis "Glycolysis / Gluconeogenesis;path:map00010;Glycine, serine and threonine metabolism;path:map00260;Methane metabolism;path:map00680;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" cytoplasm cytoplasm cytoplasm +293 YDL024C "Protein of unknown function; involved in invasive and pseudohyphal growth" 3.1.3.2 Protein of unknown function 3.1.3.2 Probable acid phosphatase DIA3 (EC 3.1.3.2) (Digs into agar protein 3) "DIA3; putative acid phosphatase DIA3" 3.1.3.2 Digs Into Agar "D-glycerate 2-phosphate + H2O = D-glycerate + phosphate;glycerol 1-phosphate + H2O = glycerol + phosphate;D-glycerate 3-phosphate + H2O = D-glycerate + phosphate;a phosphate monoester + H2O = an alcohol + phosphate;glycerol 2-phosphate + H2O = glycerol + phosphate;4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate;alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate;D-glucose 6-phosphate + H2O = D-glucose + phosphate;diphosphate + H2O = 2 phosphate;ATP + H2O = ADP + phosphate;dTTP + H2O = dTDP + phosphate;GDP + H2O = GMP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;GTP + H2O = GDP + phosphate;phosphoenolpyruvate + H2O = pyruvate + phosphate;phosphocholine + H2O = choline + phosphate;thiamine phosphate + H2O = thiamine + phosphate;FMN + H2O = riboflavin + phosphate;UDP + H2O = UMP + phosphate;dTDP + H2O = dTMP + phosphate;UTP + H2O + H+/in = UDP + phosphate + H+/out;CTP + H2O + H+/in = CDP + phosphate + H+/out;D-gluconate 6-phosphate + H2O = D-gluconate + phosphate;O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate;O-phospho-L-threonine + H2O = L-threonine + phosphate;3'AMP + H2O = adenosine + phosphate;O-phosphoserine + H2O = serine + phosphate;phenyl phosphate = phenol + phosphate;dCMP + H2O = deoxycytidine + phosphate;pyridoxamine 5'-phosphate + H2O = pyridoxamine + phosphate;pyridoxine 5'-phosphate + H2O = pyridoxine + phosphate;3'-TMP + H2O = thymidine + phosphate;2'-deoxyuridine 5'-phosphate + H2O = 2'-deoxyuridine + phosphate;adenosine 5'-diphosphate + H2O = AMP + phosphate;dAMP + H2O = 2'-deoxyadenosine + phosphate;nicotinamide mononucleotide + H2O = nicotinamide riboside + phosphate;adenosine monophosphate + H2O = adenosine + phosphate;guanosine monophosphate + H2O = guanosine + phosphate;dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate;2'-AMP + H2O = adenosine + phosphate;3'-dUMP + H2O = deoxyuridine + phosphate;3'-dCMP + H2O = deoxycytidine + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;3'-GMP + H2O = guanosine + phosphate;D-mannose 6-phosphate + H2O = D-mannose + phosphate;D-glyceraldehyde 3-phosphate + H2O = D-glyceraldehyde + phosphate;NADP+ + H2O = NAD+ + phosphate;CDP + H2O = CMP + phosphate;NADPH + H2O = NADH + phosphate;CMP + H2O = cytidine + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate;lysophosphatidate + H2O = monoacylglycerol + phosphate;uridine 5'-phosphate + H2O = uridine + phosphate;3'-UMP + H2O = uridine + phosphate;3'-CMP + H2O = cytidine + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate;2'-deoxyadenosine 3'-monophosphate + H2O = 2'-deoxyadenosine + phosphate;2'-deoxyguanosine 3'-monophosphate + H2O = 2'-deoxyguanosine + phosphate;carbamoyl phosphate + H2O = carbamate + phosphate;thiamine diphosphate + 2 H2O = thiamine + 2 phosphate;ADP + 2 H2O = adenosine + 2 phosphate" "D-glycerate 2-phosphate + H2O = D-glycerate + phosphate;glycerol 1-phosphate + H2O = glycerol + phosphate;D-glycerate 3-phosphate + H2O = D-glycerate + phosphate;a phosphate monoester + H2O = an alcohol + phosphate;glycerol 2-phosphate + H2O = glycerol + phosphate;4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate;alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate;D-glucose 6-phosphate + H2O = D-glucose + phosphate;diphosphate + H2O = 2 phosphate;ATP + H2O = ADP + phosphate;dTTP + H2O = dTDP + phosphate;GDP + H2O = GMP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;GTP + H2O = GDP + phosphate;phosphoenolpyruvate + H2O = pyruvate + phosphate;phosphocholine + H2O = choline + phosphate;thiamine phosphate + H2O = thiamine + phosphate;FMN + H2O = riboflavin + phosphate;UDP + H2O = UMP + phosphate;dTDP + H2O = dTMP + phosphate;UTP + H2O + H+/in = UDP + phosphate + H+/out;CTP + H2O + H+/in = CDP + phosphate + H+/out;D-gluconate 6-phosphate + H2O = D-gluconate + phosphate;O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate;O-phospho-L-threonine + H2O = L-threonine + phosphate;3'AMP + H2O = adenosine + phosphate;O-phosphoserine + H2O = serine + phosphate;phenyl phosphate = phenol + phosphate;dCMP + H2O = deoxycytidine + phosphate;pyridoxamine 5'-phosphate + H2O = pyridoxamine + phosphate;pyridoxine 5'-phosphate + H2O = pyridoxine + phosphate;3'-TMP + H2O = thymidine + phosphate;2'-deoxyuridine 5'-phosphate + H2O = 2'-deoxyuridine + phosphate;adenosine 5'-diphosphate + H2O = AMP + phosphate;dAMP + H2O = 2'-deoxyadenosine + phosphate;nicotinamide mononucleotide + H2O = nicotinamide riboside + phosphate;adenosine monophosphate + H2O = adenosine + phosphate;guanosine monophosphate + H2O = guanosine + phosphate;dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate;2'-AMP + H2O = adenosine + phosphate;3'-dUMP + H2O = deoxyuridine + phosphate;3'-dCMP + H2O = deoxycytidine + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;3'-GMP + H2O = guanosine + phosphate;D-mannose 6-phosphate + H2O = D-mannose + phosphate;D-glyceraldehyde 3-phosphate + H2O = D-glyceraldehyde + phosphate;NADP+ + H2O = NAD+ + phosphate;CDP + H2O = CMP + phosphate;NADPH + H2O = NADH + phosphate;CMP + H2O = cytidine + phosphate;Fructose 1-phosphate + H2O = Fructose + phosphate;alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate;lysophosphatidate + H2O = monoacylglycerol + phosphate;uridine 5'-phosphate + H2O = uridine + phosphate;3'-UMP + H2O = uridine + phosphate;3'-CMP + H2O = cytidine + phosphate;D-fructose 6-phosphate + H2O = D-fructose + phosphate;D-ribose 5-phosphate + H2O = D-ribose + phosphate;2'-deoxyadenosine 3'-monophosphate + H2O = 2'-deoxyadenosine + phosphate;2'-deoxyguanosine 3'-monophosphate + H2O = 2'-deoxyguanosine + phosphate;carbamoyl phosphate + H2O = carbamate + phosphate;thiamine diphosphate + 2 H2O = thiamine + 2 phosphate;ADP + 2 H2O = adenosine + 2 phosphate" "a phosphate monoester + H2O => an alcohol + phosphate;thiamine phosphate + H2O => thiamine + phosphate" "FMN + H2O <=> Riboflavin + Orthophosphate;Thiamin monophosphate + H2O <=> Thiamine + Orthophosphate" 3 out of 5 A phosphate monoester + H(2)O = an alcohol + phosphate. "FMN + H2O <=> Riboflavin + Orthophosphate;Thiamin monophosphate + H2O <=> Thiamine + Orthophosphate" YES Thiamine metabolism pathway from kegg "E15;E510;H18;H977" "Thiamine metabolism;Riboflavin metabolism;Metabolic pathways" phosphate acquisition // superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // thiamin diphosphate biosynthesis IV (eukaryotes) "Riboflavin metabolism;path:map00740;Metabolic pathways;path:map01100" cell envelope +305 YDL102W "Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)" 2.7.7.7 Catalytic subunit of DNA polymerase delta DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. POL3 contains the polymerase active site and most likely the active site for the 3'-5' exonuclease activity. {ECO:0000269|PubMed:1648480}. 2.7.7.7 DNA polymerase delta catalytic subunit (EC 2.7.7.7) (DNA polymerase III) "POL3, CDC2, HPR6, TEX1; DNA-directed DNA polymerase delta POL3" 2.7.7.7 POLymerase "CIA Targeting Complex transfers 4Fe-4S clusters to apoproteins;Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination" "Cytosolic iron-sulfur cluster assembly (yeast);Removal of the Flap Intermediate;Processive synthesis on the lagging strand" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus +310 YDL120W "Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog FXN is mutated in Friedrich's ataxia; human FTL gene can complement yeast yfh1 null mutant" 1.16.3.1 Mitochondrial matrix iron chaperone Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain. {ECO:0000269|PubMed:15961414, ECO:0000269|PubMed:16371422, ECO:0000269|PubMed:17027502, ECO:0000269|PubMed:19884169, ECO:0000269|PubMed:9180083, ECO:0000269|PubMed:9988680}. 1.16.3.1 Frataxin homolog, mitochondrial (EC 1.16.3.1) [Cleaved into: Frataxin homolog intermediate form] "YFH1; ferroxidase" 1.16.3.1 frataxin "TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix;TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix;Precursor proteins enter TIM23 PAM complex;Precursor proteins enter TIM23 PAM complex;MPP hydrolyzes presequence of matrix precursors;MPP hydrolyzes presequence of matrix precursors;FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster;Frataxin binds iron" "4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O;4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2" "4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O;4 Cu+ + 4 H+ + O2 = 4 Cu2+ + 2 H2O;4 Mn(II) + 4 H+ + O2 = 4 Mn(III) + 2 H2O;2 hydroquinone + O2 = 2 quinone + 2 H2O" "4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O;4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2" "4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O;4 Cu+ + 4 H+ + O2 = 4 Cu2+ + 2 H2O;4 Mn(II) + 4 H+ + O2 = 4 Mn(III) + 2 H2O;2 hydroquinone + O2 = 2 quinone + 2 H2O" a [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex + 2 Fe3+ => a [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex Oxygen + 4 Fe2+ + 4 H+ <=> 4 Fe3+ + 2 H2O 5 out of 5 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O. {ECO:0000269|PubMed:16371422}. 4 Fe(2+) + 4 H(+) + O2 <=> 4 Fe(3+) + 2 H2O YES iron-sulfur cluster biosynthesis "pathway from biocyc; reaction from biocyc is wrong; reaction from rhea" "E532;H587" Porphyrin and chlorophyll metabolism iron-sulfur cluster biosynthesis Mitochondrial iron-sulfur cluster biogenesis "Porphyrin and chlorophyll metabolism;path:map00860" mitochondrion mitochondrion mitochondrion +314 YDL140C "RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime" 2.7.7.6 RNA polymerase II largest subunit B220 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcription cycle, Pol II, general transcription factors and the Mediator complex assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcription elongation in which it moves on the template as the transcript elongates. Pol II appears to oscillate between inactive and active conformations at each step of nucleotide addition. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Pol II is composed of mobile elements that move relative to each other. The core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. The clamp element (portions of RPB1, RPB2 and RPB3) is connected to the core through a set of flexible switches and moves to open and close the cleft. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. In elongating Pol II, the lid loop (RPB1) appears to act as a wedge to drive apart the DNA and RNA strands at the upstream end of the transcription bubble and guide the RNA strand toward the RNA exit groove located near the base of the largely unstructured CTD domain of RPB1. The rudder loop (RPB1) interacts with single-stranded DNA after separation from the RNA strand, likely preventing reassociation with the exiting RNA. The cleft is surrounded by jaws: an upper jaw formed by portions of RBP1, RPB2 and RPB9, and a lower jaw, formed by RPB5 and portions of RBP1. The jaws are thought to grab the incoming DNA template, mainly by RPB5 direct contacts to DNA. 2.7.7.6 DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit 1) (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (RNA polymerase II subunit B220) "RPO21, RPB1, RPB220, SUA8; DNA-directed RNA polymerase II core subunit RPO21" 2.7.7.6 RNA POlymerase "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus "nucleus;mitochondrion;cytoplasm" nucleus +316 YDL150W RNA polymerase III subunit C53 RNA polymerase III subunit C53 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation. {ECO:0000269|PubMed:16362040}. DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (C53) (DNA-directed RNA polymerase III 47 kDa polypeptide) "RPC53, RPC4; DNA-directed RNA polymerase III subunit C53" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus +319 YDL164C "DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; DNA ligase I mutants trigger ubiquitination of PCNA at K107, facilitating Rad59p-mediated bypass of unligated Okazaki fragments; human homolog LIG1 can complement yeast cdc9 temperature-sensitive mutant at restrictive temperature" 6.5.1.1 DNA ligase I found in nucleus and mitochondria DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. The mitochondrial form is required for mitochondrial DNA maintenance but is non-essential while the nuclear form is essential for cell viability. 6.5.1.1 DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) "CDC9, MMS8; DNA ligase (ATP) CDC9" "6.5.1.1;6.5.1.6;6.5.1.7" Cell Division Cycle "LIG1 binds APEX1 and PCNA at SSB;DNA ligase I ligates single stranded nick in double stranded DNA;LIG1 bound to APEX1 and PCNA ligates SSB;Ligation of newly synthesized repair patch to incised DNA in TC-NER;Joining of adjacent Okazaki fragments" "ATP + [DNA ligase]-L-lysine = [DNA ligase]-N6-(5'-adenylyl)-L-lysine + diphosphate;ATP + ADP = P1-(5'-adenosyl),P3-(5'-adenosyl)triphosphate + diphosphate;ATP + DNA(n) + 5'-Phospho-DNA(m) <=> AMP + Diphosphate + DNA(n+m);[DNA]-3'-hydroxyl + 5'-phospho-[DNA] + ATP = DNAn + AMP + diphosphate;dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n;[DNA ligase]-N6-(5'-adenylyl)-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;ADP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + phosphate + (deoxyribonucleotide)n+m;ATP + (deoxyribonucleotide)20 + (deoxyribonucleotide)20 = AMP + diphosphate + (deoxyribonucleotide)40;ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)m+n;ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m;ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate;(deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP" "ATP + [DNA ligase]-L-lysine = [DNA ligase]-N6-(5'-adenylyl)-L-lysine + diphosphate;ATP + ADP = P1-(5'-adenosyl),P3-(5'-adenosyl)triphosphate + diphosphate;ATP + DNA(n) + 5'-Phospho-DNA(m) <=> AMP + Diphosphate + DNA(n+m);[DNA]-3'-hydroxyl + 5'-phospho-[DNA] + ATP = DNAn + AMP + diphosphate;dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n;[DNA ligase]-N6-(5'-adenylyl)-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine;ADP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + phosphate + (deoxyribonucleotide)n+m;ATP + (deoxyribonucleotide)20 + (deoxyribonucleotide)20 = AMP + diphosphate + (deoxyribonucleotide)40;ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)m+n;ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m;ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate;(deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP" a [DNA]-3'-hydroxyl + a 5'-phospho-[DNA] + ATP => DNAn + AMP + diphosphate "ATP + DNA(n) + 5'-Phospho-DNA(m) <=> AMP + Diphosphate + DNA(n+m);NAD+ + DNA(n) + 5'-Phospho-DNA(m) <=> AMP + Nicotinamide D-ribonucleotide + DNA(n+m);ADP + DNA(n) + 5'-Phospho-DNA(m) <=> AMP + Orthophosphate + DNA(n+m);GTP + DNA(n) + 5'-Phospho-DNA(m) <=> GMP + Diphosphate + DNA(n+m)" 5 out of 5 ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate. {ECO:0000255|PROSITE-ProRule:PRU10135}. 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" "DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Gap-filling DNA repair synthesis and ligation in TC-NER;Processive synthesis on the lagging strand" NA "mitochondrion;nucleus" "nucleus;mitochondrion" "mitochondrion;nucleus" +320 YDL166C "Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p; complex with Rps14 is conserved between humans, yeast, and arches; may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes; human TAF9 functionally complements the lethality of the null mutation" 2.7.4.3 Essential NTPase required for small ribosome subunit synthesis Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity (By similarity). Involved in 18S rRNA maturation. Required for cleavage of the 20S pre-rRNA at site D in the cytoplasm. Involved in oxidative stress response. Required for POS9-dependent target gene transcription upon oxidative stress. {ECO:0000255|HAMAP-Rule:MF_03173, ECO:0000269|PubMed:10692169, ECO:0000269|PubMed:12837249, ECO:0000269|PubMed:16287850}. 2.7.4.3 Adenylate kinase isoenzyme 6 homolog FAP7 (AK6) (EC 2.7.4.3) (Dual activity adenylate kinase/ATPase) (AK/ATPase) (POS9-activating factor 7) "FAP7; nucleoside-triphosphatase" 2.7.4.3 Factor Activating Pos9 AK6 phosphorylates (d)NMPs to (d)NDPs "AMP + ATP => 2 ADP;2 ADP => AMP + ATP" "ATP + AMP = 2 ADP;ATP + dAMP = ADP + dADP;GTP + AMP = GDP + ADP;ATP + CDP = ADP + CTP;ATP + CMP = ADP + CDP;UTP + AMP = UDP + ADP;Thiamin diphosphate + ADP <=> Thiamin triphosphate + AMP" "AMP + ATP => 2 ADP;2 ADP => AMP + ATP" "ATP + AMP = 2 ADP;ATP + dAMP = ADP + dADP;GTP + AMP = GDP + ADP;ATP + CDP = ADP + CTP;ATP + CMP = ADP + CDP;UTP + AMP = UDP + ADP;Thiamin diphosphate + ADP <=> Thiamin triphosphate + AMP" "ATP + AMP <=> 2 ADP;ATP + dAMP <=> ADP + dADP" AK6 phosphorylates (d)NMPs to (d)NDPs 5 out of 5 ATP + AMP = 2 ADP. {ECO:0000255|HAMAP-Rule:MF_03173}. "ATP + AMP <=> 2 ADP;ATP + dAMP <=> ADP + dADP" YES Purine metabolism pathway from kegg "E228;E598;H56" "Purine metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Ribosome biogenesis in eukaryotes" Interconversion of nucleotide di- and triphosphates "Purine metabolism;path:map00230;Thiamine metabolism;path:map00730;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Biosynthesis of antibiotics;path:map01130" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +323 YDL193W "Forms dehydrodolichyl diphosphate syntase complex with RER2 or SRT1; tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY, suggesting that Nus1p may be involved in protein trafficking; mutations in human homolog NUS1 have been implicated in congenital scoliosis, neurological impairment, refractory epilepsy, hearing deficit, and visual impairment; human cis-prenyltransferase complex complements yeast null mutant" 2.5.1.87 Forms dehydrodolichyl diphosphate syntase complex with RER2 or SRT1 With SRT1 or RER2, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). {ECO:0000269|PubMed:25066056}. 2.5.1.87 Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Di-trans,poly-cis-decaprenylcistransferase) (Nuclear undecaprenyl pyrophosphate synthase 1) (Undecaprenyl diphosphate synthase) (UDS) "NUS1; ditrans,polycis-polyprenyl diphosphate synthase" 2.5.1.87 dehydrodolichyl diphosphate syntase NUS1 subunit DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP NA "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate;(2E,6E)-farnesyl diphosphate + 13 isopentenyl diphosphate = 13 diphosphate + di-trans,poly-cis-hexadecaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = di-trans, poly-cis-polyisoprenyl diphosphate + diphosphate;geranyl diphosphate + n isopentenyl diphosphate = n diphosphate + di-trans,poly-cis-polyprenyl diphosphate;(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n: 10-55);(2E,6E)-farnesyl diphosphate + 14 isopentenyl diphosphate = 14 diphosphate + di-trans,poly-cis-heptadecaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + di-trans,poly-cis-octaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + di-trans,poly-cis-nonaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 19 isopentenyl diphosphate = 19 diphosphate + di-trans,poly-cis-docosaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 21 isopentenyl diphosphate = 21 diphosphate + di-trans,poly-cis tetracosaprenyl diphosphate" NA "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate;(2E,6E)-farnesyl diphosphate + 13 isopentenyl diphosphate = 13 diphosphate + di-trans,poly-cis-hexadecaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = di-trans, poly-cis-polyisoprenyl diphosphate + diphosphate;geranyl diphosphate + n isopentenyl diphosphate = n diphosphate + di-trans,poly-cis-polyprenyl diphosphate;(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n: 10-55);(2E,6E)-farnesyl diphosphate + 14 isopentenyl diphosphate = 14 diphosphate + di-trans,poly-cis-heptadecaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + di-trans,poly-cis-octaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + di-trans,poly-cis-nonaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 19 isopentenyl diphosphate = 19 diphosphate + di-trans,poly-cis-docosaprenyl diphosphate;(2E,6E)-farnesyl diphosphate + 21 isopentenyl diphosphate = 21 diphosphate + di-trans,poly-cis tetracosaprenyl diphosphate" (2E,6E)-farnesyl diphosphate + 13 isopentenyl diphosphate => di-trans, poly-cis-polyprenyl diphosphate (C80) + 13 diphosphate trans,trans-Farnesyl diphosphate + n Isopentenyl diphosphate <=> Dehydrodolichol diphosphate + n Diphosphate NA 5 out of 5 (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55). {ECO:0000269|PubMed:25066056}. trans,trans-Farnesyl diphosphate + n Isopentenyl diphosphate <=> Dehydrodolichol diphosphate + n Diphosphate YES Terpenoid backbone biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation. {ECO:0000305}." "Terpenoid backbone biosynthesis;Biosynthesis of secondary metabolites" dolichol and dolichyl phosphate biosynthesis Synthesis of Dolichyl-phosphate "Terpenoid backbone biosynthesis;path:map00900;Biosynthesis of secondary metabolites;path:map01110" "endoplasmic reticulum membrane;lipid particle;nucleus" "nucleus;endoplasmic reticulum;endoplasmic reticulum membrane;lipid particle" "nucleus;endoplasmic reticulum membrane;lipid particle" +327 YDL219W "D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes" 3.1.-.- D-Tyr-tRNA(Tyr) deacylase " An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs (Probable). Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr) (PubMed:10766779). May also deacylate mischarged D-leucyl-tRNA(Leu) (PubMed:10918062). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality (By similarity). {ECO:0000250|UniProtKB:Q8IIS0, ECO:0000269|PubMed:10766779, ECO:0000305|PubMed:10918062}." "3.1.1.96; 3.1.1.-" D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (EC 3.1.1.-) "DTD1; D-tyrosyl-tRNA(Tyr) deacylase" NA D-Tyr-tRNA(Tyr) Deacylase NA NA NA "a D-aminoacyl-tRNA + H2O => a D-amino acid + H(+) + tRNA;a D-amino acid + H(+) + tRNA => a D-aminoacyl-tRNA + H2O" "D-aminoacyl-[tRNA] + H2O = D-amino acid + uncharged tRNA + H+;D-tyrosyl-tRNATyr + H2O = D-tyrosine + tRNATyr;a D-aminoacyl-tRNA + H2O = a D-amino acid + tRNA;D-aminoacyl-tRNA + H2O = D-amino acid + tRNA;D-Tyr-tRNA + H2O = D-Tyr + tRNA" NA NA NA 5 out of 5 "Glycyl-tRNA(Ala) + H(2)O = glycine + tRNA(Ala). {ECO:0000250|UniProtKB:Q8IIS0}.; A D-aminoacyl-tRNA + H(2)O = a D-amino acid + tRNA. {ECO:0000305|PubMed:10766779}." "Glycyl-tRNA(Ala) + H(2)O <=> glycine + tRNA(Ala); D-leucyl-tRNA(Leu) <=> D-leu + tRNA(Leu); D-tyrosyl-tRNA(Tyr) <=> D-tyrosine + tRNA(Tyr)" YES other "D-Tyr-tRNA(Tyr) deacylase;" "NA;NA" NA NA NA NA NA "NA;NA" cytoplasm cytoplasm cytoplasm +330 YDL232W "Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex" 2.4.99.18 Subunit of the oligosaccharyltransferase complex of the ER lumen Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. OST4 is required for recruitment of OST3 or OST6 to the OST complex. It is essential for cell growth at 37 but not at 25 degrees Celsius. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4 (Oligosaccharyl transferase subunit OST4) (EC 2.4.99.18) (Oligosaccharyl transferase 4 kDa subunit) (OTase 4 kDa subunit) "OST4; olichyl-diphosphooligosaccharide--protein glycotransferase OST4" oligosaccharyl transferase complex OST4 subunit "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "mitochondrion;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +331 YDL236W "Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts" 3.1.3.41 Conserved phosphatase acting as a metabolite repair enzyme PHO13 is dispensable for vegetative growth and sporulation. 3.1.3.41 4-nitrophenylphosphatase (PNPPase) (EC 3.1.3.41) "PHO13; 4-nitrophenylphosphatase" 3.1.3.41 p-nitrophenyl phosphatase "4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate;4-nitrophenol + H(+) + phosphate => 4-nitrophenyl phosphate + H2O" 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate "4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate;4-nitrophenol + H(+) + phosphate => 4-nitrophenyl phosphate + H2O" 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate 4-nitrophenyl phosphate + H2O => 4-nitrophenol + phosphate + H+ 4-Nitrophenyl phosphate + H2O <=> 4-Nitrophenol + Orthophosphate 5 out of 5 4-nitrophenyl phosphate + H(2)O = 4-nitrophenol + phosphate. 4-nitrophenyl phosphate + H2O <=> 4-nitrophenol + phosphate YES Aminobenzoate degradation pathway from kegg H639 "Aminobenzoate degradation;path:map00627;Microbial metabolism in diverse environments;path:map01120" "nucleus;cytoplasm" +332 YDL243C "Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" Putative aryl-alcohol dehydrogenase 1.1.1.- Probable aryl-alcohol dehydrogenase AAD4 (EC 1.1.1.-) "AAD4; putative aryl-alcohol dehydrogenase" aryl-alcohol dehydrogenase "3-chlorobenzyl alcohol + NAD+ = 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ = 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ = 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ = p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ = 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ = an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ = benzaldehyde + NADH + H+" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism "pathway from E.coli model; reaction from biocyc" "E646;E743;H1286" NA +333 YDL244W "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" Protein involved in synthesis of the thiamine precursor HMP Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. {ECO:0000250|UniProtKB:P43534}. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI13 (HMP-P synthase) (Hydroxymethylpyrimidine phosphate synthase) (Thiamine biosynthesis protein 13) (Thiamine pyrimidine synthase) "THI13; 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" MONOMER3O-9145 [an HMP-P synthase]-L-histidine + pyridoxal 5'-phosphate => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + an HMP-P synthase Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine 3 out of 5 NA Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine YES Thiamine metabolism pathway from kegg thiamine biosynthesis "PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000305|PubMed:12777485}." "Thiamine metabolism;Metabolic pathways" superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis NA +334 YDL246C "Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase" 1.1.1.14 Sorbitol dehydrogenase 1.1.1.14 Sorbitol dehydrogenase 2 (EC 1.1.1.14) (L-iditol 2-dehydrogenase 2) "SOR2; L-iditol 2-dehydrogenase SOR2" 1.1.1.14 Unknown "L-iditol + NAD(+) => L-sorbopyranose + H(+) + NADH;L-sorbopyranose + H(+) + NADH => L-iditol + NAD(+)" "xylitol + NAD+ = D-xylulose + NADH + H+;L-iditol + NAD+ = L-sorbose + NADH + H+;ribitol + NAD+ = D-ribulose + NADH + H+;D-mannitol + NAD+ = D-fructose + NADH + H+;D-sorbitol + NAD+ = D-fructose + NADH + H+;L-arabinose + NADH = L-arabitol + NAD+;D-galactose + NADH = dulcitol + NAD+;L-threitol + NAD+ = L-erythrulose + NADH + H+;D-sorbitol + NADH + H+ = D-fructose + NADH + H+;D-sorbitol + NAD+ = L-sorbose + NADH + H+" "L-iditol + NAD(+) => L-sorbopyranose + H(+) + NADH;L-sorbopyranose + H(+) + NADH => L-iditol + NAD(+)" "xylitol + NAD+ = D-xylulose + NADH + H+;L-iditol + NAD+ = L-sorbose + NADH + H+;ribitol + NAD+ = D-ribulose + NADH + H+;D-mannitol + NAD+ = D-fructose + NADH + H+;D-sorbitol + NAD+ = D-fructose + NADH + H+;L-arabinose + NADH = L-arabitol + NAD+;D-galactose + NADH = dulcitol + NAD+;L-threitol + NAD+ = L-erythrulose + NADH + H+;D-sorbitol + NADH + H+ = D-fructose + NADH + H+;D-sorbitol + NAD+ = L-sorbose + NADH + H+" "D-sorbitol + NAD+ => keto-D-fructose + NADH + H+;L-iditol + NAD+ = keto-L-sorbose + NADH + H+" "D-Sorbitol + NAD+ <=> D-Fructose + NADH + H+;Xylitol + NAD+ <=> D-Xylulose + NADH + H+" 3 out of 5 L-iditol + NAD(+) = L-sorbose + NADH. "D-sorbitol + NAD+ => keto-D-fructose + NADH + H+;L-iditol + NAD+ = keto-L-sorbose + NADH + H+" YES Pentose and glucuronate interconversions pathway from kegg H527 "Pentose and glucuronate interconversions;Fructose and mannose metabolism;Metabolic pathways" sorbitol degradation "Pentose and glucuronate interconversions;path:map00040;Fructose and mannose metabolism;path:map00051;Metabolic pathways;path:map01100" +335 YDR009W "Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication" NA Transcriptional regulator The GAL3 regulatory function is required for rapid induction of the galactose system. At normal induction, galactose in the presence of the GAL3 protein may lead to the induction of the GAL genes, including GAL1. Then the galactokinase protein (GAL1) in the presence of galactose may reinforce the induction leading to a higher expression level. Upon depletion of galactose, the inducing activity of the galactokinase protein may decrease, after which transcription of the GAL genes, including GAL1, may decrease. NA Protein GAL3 "GAL3; transcriptional regulator GAL3" 2.7.1.6 GALactose metabolism GALK1 phosphorylates Gal to Gal1P NA NA NA NA NA ATP + alpha-D-Galactose <=> ADP + alpha-D-Galactose 1-phosphate GALK1 phosphorylates Gal to Gal1P 4 out of 5 NA ATP + alpha-D-Galactose <=> ADP + alpha-D-Galactose 1-phosphate YES Galactose metabolism pathway from kegg NA NA NA "Galactose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways" NA Galactose catabolism NA "nucleus;cytoplasm" +337 YDR020C "Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases" 2.7.1.48 Putative protein of unknown function Putative uridine kinase identified in a screen for mutants with increased levels of rDNA transcription. {ECO:0000269|PubMed:19270272}. 2.7.1.48 Putative uridine kinase DAS2 (EC 2.7.1.48) (DST1-delta 6-azauracil sensitivity protein 2) (Regulator of rDNA transcription 3) "DAS2, RRT3; putative uridine kinase DAS2" uridine kinase "ATP + uridine => ADP + H(+) + UMP;ADP + H(+) + UMP => ATP + uridine" "ATP + CMP = ADP + CDP;ATP + uridine = ADP + UMP;ATP + cytidine = ADP + CMP;dATP + cytidine = dADP + CMP;dUTP + cytidine = dUDP + CMP;dCTP + cytidine = dCDP + CMP;GTP + uridine = UMP + GDP;GTP + cytidine = CMP + GDP;ITP + uridine = IDP + UMP;ATP + 5-fluorouridine = ADP + 5-fluorouridine 5'-monophosphate;dATP + uridine = dADP + UMP;dGTP + uridine = dGDP + UMP;dUTP + uridine = dUDP + UMP;dCTP + uridine = dCDP + UMP;dTTP + uridine = dTDP + UMP;UTP + cytidine = UDP + cytidine 5'-phosphate;ITP + cytidine = IDP + CMP;UTP + Uridine <=> UDP + UMP;dGTP + Cytidine <=> dGDP + CMP;dTTP + Cytidine <=> dTDP + CMP;ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine = ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine 5'-phosphate;ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine = ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine 5'-phosphate" "ATP + uridine => ADP + H(+) + UMP;ADP + H(+) + UMP => ATP + uridine" "ATP + CMP = ADP + CDP;ATP + uridine = ADP + UMP;ATP + cytidine = ADP + CMP;dATP + cytidine = dADP + CMP;dUTP + cytidine = dUDP + CMP;dCTP + cytidine = dCDP + CMP;GTP + uridine = UMP + GDP;GTP + cytidine = CMP + GDP;ITP + uridine = IDP + UMP;ATP + 5-fluorouridine = ADP + 5-fluorouridine 5'-monophosphate;dATP + uridine = dADP + UMP;dGTP + uridine = dGDP + UMP;dUTP + uridine = dUDP + UMP;dCTP + uridine = dCDP + UMP;dTTP + uridine = dTDP + UMP;UTP + cytidine = UDP + cytidine 5'-phosphate;ITP + cytidine = IDP + CMP;UTP + Uridine <=> UDP + UMP;dGTP + Cytidine <=> dGDP + CMP;dTTP + Cytidine <=> dTDP + CMP;ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine = ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine 5'-phosphate;ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine = ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine 5'-phosphate" "uridine + ATP => UMP + ADP + H+;uridine + GTP => UMP + GDP + H+" 4 out of 5 "ATP + uridine = ADP + UMP.; ATP + cytidine = ADP + CMP." "uridine + ATP => UMP + ADP + H+;uridine + GTP => UMP + GDP + H+" YES Pyrimidine metabolism pathway from kegg "E28;H578;H1022" "PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1." pyrimidine ribonucleosides salvage I // salvage pathways of pyrimidine ribonucleotides "Pyrimidine metabolism;path:map00240;Drug metabolism - other enzymes;path:map00983;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +339 YDR036C "3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis" 3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:14566057, PubMed:25609543, PubMed:28154081). mS47 has enzymatic activity in vitro, and is able to catalyze the specific hydrolysis of 3-hydroxyisobutyryl-CoA (HIBYL-CoA). However, because the turnover rate of mS47/EHD3 is only a fraction of that of the homologous mammalian enzyme, the physiological function of this activity remains unclear (PubMed:12697341). Has an indirect role in endocytic membrane trafficking (PubMed:11378903). {ECO:0000269|PubMed:11378903, ECO:0000269|PubMed:12697341, ECO:0000305|PubMed:14566057, ECO:0000305|PubMed:25609543, ECO:0000305|PubMed:28154081}. 3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H) (Mitochondrial small ribosomal subunit protein mS47) "EHD3; Ehd3p" 3.1.2.4 EHD3 beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA "3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+);3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O" "3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate;(S)-3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + (S)-3-hydroxy-2-methylpropanoate;L-3-hydroxybutyryl-CoA + H2O = CoA + L-3-hydroxybutyrate;3-hydroxypropanoyl-CoA + H2O = CoA + 3-hydroxypropanoate" "3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+);3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O" "3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate;(S)-3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + (S)-3-hydroxy-2-methylpropanoate;L-3-hydroxybutyryl-CoA + H2O = CoA + L-3-hydroxybutyrate;3-hydroxypropanoyl-CoA + H2O = CoA + 3-hydroxypropanoate" "3-Hydroxypropanoate + CoA <=> 3-Hydroxypropionyl-CoA + H2O;(S)-3-Hydroxyisobutyryl-CoA + H2O <=> CoA + (S)-3-Hydroxyisobutyrate" 4 out of 5 3-hydroxy-2-methylpropanoyl-CoA + H(2)O = CoA + 3-hydroxy-2-methylpropanoate. {ECO:0000269|PubMed:12697341}. 3-hydroxy-2-methylpropanoyl-CoA + H2O <=> 3-hydroxy-2-methylpropanoate + CoA + H(+) YES valine, leucine and isoleucine metabolism "pathway from kegg; Valine, leucine and isoleucine degradation was changed into Valine, leucine and isoleucine metabolism based on yeast7.7; reaction from rhea" H13 "Valine, leucine and isoleucine degradation;beta-Alanine metabolism;Propanoate metabolism;Metabolic pathways;Carbon metabolism" Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation;path:map00280;beta-Alanine metabolism;path:map00410;Propanoate metabolism;path:map00640;Metabolic pathways;path:map01100" mitochondrion "mitochondrion;cytoplasm" mitochondrion +340 YDR038C "Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family" 3.6.3.7 Protein with similarity to P-type ATPase sodium pumps This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithium ions to allow salt tolerance. {ECO:0000250}. 3.6.3.7 Sodium transport ATPase 5 (EC 3.6.3.7) "ENA5; putative Na(+)-exporting P-type ATPase ENA5" Exitus NAtru (Latin, \exit sodium\) "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ 3 out of 5 ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out). Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ YES sodium transport E586 NA cell envelope cell envelope cell envelope +341 YDR039C "P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux" 3.6.3.7 P-type ATPase sodium pump This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithiums ions to allow salt tolerance. {ECO:0000269|PubMed:7664728, ECO:0000269|PubMed:8437581}. 3.6.3.7 Sodium transport ATPase 2 (EC 3.6.3.7) "ENA2; Na(+)-exporting P-type ATPase ENA2" 3.6.3.7 Exitus NAtru (Latin, \exit sodium\) "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ 5 out of 5 ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out). Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ YES sodium transport E586 NA cell envelope "mitochondrion;cell envelope" cell envelope +342 YDR040C "P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance" 3.6.3.7 P-type ATPase sodium pump This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3. {ECO:0000269|PubMed:7664728, ECO:0000269|PubMed:9315618}. 3.6.3.7 Sodium transport ATPase 1 (EC 3.6.3.7) "ENA1, HOR6, PMR2; Na(+)/Li(+)-exporting P-type ATPase ENA1" Exitus NAtru (Latin, \exit sodium\) "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate;ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)" "ATP + H2O = ADP + phosphate;ATP + H2O + Na+/in = ADP + phosphate + Na+/out" Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ 5 out of 5 ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out). Na+[in] + ATP + H2O => Na+[out] + ADP + phosphate + H+ YES sodium transport E586 NA cell envelope "vacuole;cell envelope" cell envelope +343 YDR045C "RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS" RNA polymerase III subunit C11 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in Pol III transcription reinitiation and RNA cleavage during transcription termination. {ECO:0000269|PubMed:16362040}. DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerases III 12.5 kDa polypeptide) (RNA polymerase III subunit C11) "RPC11; DNA-directed RNA polymerase III core subunit RPC11" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus +344 YDR051C "Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel" 3.1.3.- Acid phosphatase Metal-independent, broad-range acid phosphatase. Involved, either directly or indirectly, in the bidirectional transport of sterols between the endoplasmic reticulum and the plasma membrane. {ECO:0000269|PubMed:19060182, ECO:0000269|PubMed:19753119}. 3.1.3.- Broad-range acid phosphatase DET1 (EC 3.1.3.-) (Decreased ergosterol transport protein 1) "DET1; acid phosphatase DET1" Decreased Ergosterol Transport 2-phospho-D-glycerate <=> 3-phospho-D-glycerate 4 out of 5 NA sterols <=> sterols YES sterols transport transport of sterols "E88;E587;H1052" gluconeogenesis // glycolysis NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +353 YDR093W "Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication" 3.6.3.1 Aminophospholipid translocase (flippase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles. {ECO:0000269|PubMed:12221123}. 3.6.3.1 Phospholipid-transporting ATPase DNF2 (EC 3.6.3.1) (Flippase DNF2) "DNF2; aminophospholipid-translocating P4-type ATPase DNF2" 3.6.3.1 Drs2 Neo1 Family "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). a phospholipid[in] + ATP + H2O => a phospholipid[out] + ADP + phosphate + H+ YES phospholipids transport "E586;H449" Ion transport by P-type ATPases NA cell envelope "Golgi membrane;endoplasmic reticulum;cell envelope" cell envelope +354 YDR105C "Vacuolar membrane protein of unknown function; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance" Vacuolar membrane protein of unknown function Membrane protein TMS1 "TMS1; Tms1p" Unknown "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane;SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane" "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane;SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane" 2 out of 5 NA L-ser <=> L-ser YES L-ser transport Serine biosynthesis NA vacuole +356 YDR111C "Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, that arose from the whole genome duplication" 2.6.1.2 Catalytically inactive alanine transaminase 2.6.1.2 Probable alanine aminotransferase (EC 2.6.1.2) (Glutamate pyruvate transaminase) (GPT) (Glutamic--alanine transaminase) (Glutamic--pyruvic transaminase) "ALT2; alanine transaminase ALT2" 2.6.1.2 transaminase "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2];alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2];alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT];pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT]" "2-oxoglutarate + L-alanine => L-glutamate + pyruvate;L-glutamate + pyruvate => 2-oxoglutarate + L-alanine" "L-alanine + 2-oxoglutarate = pyruvate + L-glutamate;serine + 2-oxoglutarate = 3-hydroxy-2-oxopropanoate + glutamate;2-oxoglutarate + 6-aminohexanoate = glutamate + 6-oxohexanoate;D-alanine + 2-oxoglutarate = pyruvate + D-glutamate" "2-oxoglutarate + L-alanine => L-glutamate + pyruvate;L-glutamate + pyruvate => 2-oxoglutarate + L-alanine" "L-alanine + 2-oxoglutarate = pyruvate + L-glutamate;serine + 2-oxoglutarate = 3-hydroxy-2-oxopropanoate + glutamate;2-oxoglutarate + 6-aminohexanoate = glutamate + 6-oxohexanoate;D-alanine + 2-oxoglutarate = pyruvate + D-glutamate" 2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate L-Alanine + 2-Oxoglutarate <=> Pyruvate + L-Glutamate 3 out of 5 L-alanine + 2-oxoglutarate = pyruvate + L-glutamate. L-Alanine + 2-Oxoglutarate <=> Pyruvate + L-Glutamate YES Alanine, aspartate and glutamate metabolism pathway from kegg "E42;H82" "PATHWAY: Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1." "Arginine biosynthesis;Alanine, aspartate and glutamate metabolism;Metabolic pathways;Carbon metabolism;2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids" alanine degradation III // alanine biosynthesis Amino acid synthesis and interconversion (transamination) "Arginine biosynthesis;path:map00220;Alanine, aspartate and glutamate metabolism;path:map00250;Carbon fixation in photosynthetic organisms;path:map00710;Metabolic pathways;path:map01100;Microbial metabolism in diverse environments;path:map01120" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +358 YDR121W "Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization" 2.7.7.7 Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. Also functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex. {ECO:0000269|PubMed:11024162, ECO:0000269|PubMed:11081629, ECO:0000269|PubMed:11238944, ECO:0000269|PubMed:11533234, ECO:0000269|PubMed:12124389, ECO:0000269|PubMed:14673157}. 2.7.7.7 DNA polymerase epsilon subunit D (EC 2.7.7.7) (DNA polymerase II subunit D) "DPB4; DNA polymerase epsilon noncatalytic subunit" 2.7.7.7 DNA Polymerase B (II) subunit "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus +365 YDR156W RNA polymerase I subunit A14 RNA polymerase I subunit A14 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. RPA14 seems to play a role in the stability of subunits RPO26 and RPA43. In vitro, the RPA14-RPA43 subcomplex binds single-stranded RNA. {ECO:0000269|PubMed:12888498, ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerase I subunit RPA14 (A14) (DNA-directed RNA polymerase I 14 kDa polypeptide) "RPA14; DNA-directed RNA polymerase I subunit RPA14" RNA Polymerase A a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus +370 YDR231C "Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase" NA Mitochondrial inner membrane protein Involved in the assembly of the cytochrome oxidase complex. Required for the maturation and subsequent assembly of the mitochondrially encoded COX2, the precursor of subunit 2 of cytochrome oxidase. {ECO:0000269|PubMed:10671482}. NA Cytochrome c oxidase protein 20, mitochondrial "COX20; Cox20p" NA Cytochrome c OXidase NA NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 4 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA NA aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +371 YDR242W Putative amidase 3.5.1.4 Putative amidase 3.5.1.4 Probable amidase (EC 3.5.1.4) "AMD2; putative amidase" 3.5.1.4 amidase "FAAH hydrolyses AEA to AA and ETA;FAAH2 hydrolyses AEA to AA and ETA" "a monocarboxylic acid amide + H2O => a monocarboxylate + NH4(+);a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O;H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+);(indol-3-yl)acetate + NH4(+) => H2O + indole-3-acetamide;acetamide + H2O => acetate + NH4(+);acetate + NH4(+) => acetamide + H2O" "a monocarboxylic acid amide + H2O = a monocarboxylate + NH3;anandamide + H2O = arachidonic acid + ethanolamine;pyrazinamide + H2O = pyrazinoic acid + NH3;an acetic ester + H2O = an alcohol + acetate;indole-3-acetamide + H2O = indole-3-acetic acid + NH3;propionamide + H2O = propionic acid + NH3;phenylacetamide = phenylacetic acid + NH3;benzamide + H2O = benzoic acid + NH3;acetamide + H2O = acetic acid + NH3;acrylamide + H2O = acrylic acid + NH3;4-Guanidinobutanamide + H2O <=> 4-Guanidinobutanoate + Ammonia;ethyl propionate + H2O = ethanol + propionate;glutaramic acid + H2O = glutaric acid + NH3;2-hydroxyisobutyramide + H2O = 2-hydroxyisobutanoate + ammonium;2-arylpropionic amide + H2O = S-2-arylpropionic acid + NH3;isobutyramide + H2O = isobutyrate + NH3;2-chloropropionamide + H2O = 2-chloropropionate + NH3;butyramide + H2O = n-butyrate + NH3;2 indole-3-acetonitrile + 3 H2O = indole-3-acetamide + indole-3-acetic acid + NH3;N-methylpropionamide + H2O = methylamine + propionate;DL-lactamide + H2O = DL-lactate + NH3;pivalamide + H2O = pivalate + NH3;propionohydrazide + H2O = hydrazine + propionate;N-oleoylethanolamine + H2O = oleic acid + ethanolamine;2-arachidonoylglycerol + H2O = arachidonic acid + glycerol;N-methylacetamide + H2O = methylamine + acetate;acetanilide + H2O = acetate + aniline;acetohydrazide + H2O = hydrazine + acetate;acetohydroxamate + H2O = hydroxylamine + acetate;monoamidated dicarboxylate + H2O = dicarboxylate + ammonia;ethyl acrylate + H2O = acrylate + ethanol;1-naphthaleneacetamide + H2O = 1-naphthaleneacetic acid + NH3;(R)-(+)-2-chloropropionamide + H2O = (+)-2-chloropropionic acid + NH3;(S)-(-)-2-chloropropionamide + H2O = (-)-2-chloropropionic acid + NH3;propionohydroxamate + H2O = hydroxylamine + propionate;hydroxylamine + acylamide = acylhydroxamate + NH3;carboxylic acid ester + hydroxylamine = N-hydroxy-carboxylic acid amide + alcohol;carboxylic acid + hydroxylamine = N-hydroxy-carboxylic acid amide + H2O;phenetidine + acetate = phenacetin + H2O;3,3,3-trifluoro-2-hydroxy-2-methylpropanamide + H2O = 3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid + NH3;ketoprofen amide = 2-(3-benzoylphenyl)propionic acid + NH3" "a monocarboxylic acid amide + H2O => a monocarboxylate + NH4(+);a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O;H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+);(indol-3-yl)acetate + NH4(+) => H2O + indole-3-acetamide;acetamide + H2O => acetate + NH4(+);acetate + NH4(+) => acetamide + H2O" "a monocarboxylic acid amide + H2O = a monocarboxylate + NH3;anandamide + H2O = arachidonic acid + ethanolamine;pyrazinamide + H2O = pyrazinoic acid + NH3;an acetic ester + H2O = an alcohol + acetate;indole-3-acetamide + H2O = indole-3-acetic acid + NH3;propionamide + H2O = propionic acid + NH3;phenylacetamide = phenylacetic acid + NH3;benzamide + H2O = benzoic acid + NH3;acetamide + H2O = acetic acid + NH3;acrylamide + H2O = acrylic acid + NH3;4-Guanidinobutanamide + H2O <=> 4-Guanidinobutanoate + Ammonia;ethyl propionate + H2O = ethanol + propionate;glutaramic acid + H2O = glutaric acid + NH3;2-hydroxyisobutyramide + H2O = 2-hydroxyisobutanoate + ammonium;2-arylpropionic amide + H2O = S-2-arylpropionic acid + NH3;isobutyramide + H2O = isobutyrate + NH3;2-chloropropionamide + H2O = 2-chloropropionate + NH3;butyramide + H2O = n-butyrate + NH3;2 indole-3-acetonitrile + 3 H2O = indole-3-acetamide + indole-3-acetic acid + NH3;N-methylpropionamide + H2O = methylamine + propionate;DL-lactamide + H2O = DL-lactate + NH3;pivalamide + H2O = pivalate + NH3;propionohydrazide + H2O = hydrazine + propionate;N-oleoylethanolamine + H2O = oleic acid + ethanolamine;2-arachidonoylglycerol + H2O = arachidonic acid + glycerol;N-methylacetamide + H2O = methylamine + acetate;acetanilide + H2O = acetate + aniline;acetohydrazide + H2O = hydrazine + acetate;acetohydroxamate + H2O = hydroxylamine + acetate;monoamidated dicarboxylate + H2O = dicarboxylate + ammonia;ethyl acrylate + H2O = acrylate + ethanol;1-naphthaleneacetamide + H2O = 1-naphthaleneacetic acid + NH3;(R)-(+)-2-chloropropionamide + H2O = (+)-2-chloropropionic acid + NH3;(S)-(-)-2-chloropropionamide + H2O = (-)-2-chloropropionic acid + NH3;propionohydroxamate + H2O = hydroxylamine + propionate;hydroxylamine + acylamide = acylhydroxamate + NH3;carboxylic acid ester + hydroxylamine = N-hydroxy-carboxylic acid amide + alcohol;carboxylic acid + hydroxylamine = N-hydroxy-carboxylic acid amide + H2O;phenetidine + acetate = phenacetin + H2O;3,3,3-trifluoro-2-hydroxy-2-methylpropanamide + H2O = 3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid + NH3;ketoprofen amide = 2-(3-benzoylphenyl)propionic acid + NH3" "4-guanidinobutyramide + H2O = ammonium + 4-guanidinobutanoate;a monocarboxylic acid amide + H2O = a monocarboxylate + ammonium;acrylamide + H2O = ammonium + acrylate;indole-3-acetamide + H2O = indole-3-acetate + ammonium;nicotinamide + H2O => ammonium + nicotinate" "2-Phenylacetamide + H2O <=> Phenylacetic acid + Ammonia;(Indol-3-yl)acetamide + H2O <=> Indole-3-acetate + Ammonia;4-Guanidinobutanamide + H2O <=> 4-Guanidinobutanoate + Ammonia;Monocarboxylic acid amide + H2O <=> Carboxylate + Ammonia;Acrylic acid + Ammonia <=> Acrylamide + H2O;Benzamide + H2O <=> Benzoate + Ammonia" 2 out of 5 A monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3). "2-Phenylacetamide + H2O <=> Phenylacetic acid + Ammonia;(Indol-3-yl)acetamide + H2O <=> Indole-3-acetate + Ammonia;4-Guanidinobutanamide + H2O <=> 4-Guanidinobutanoate + Ammonia;Monocarboxylic acid amide + H2O <=> Carboxylate + Ammonia;Acrylic acid + Ammonia <=> Acrylamide + H2O;Benzamide + H2O <=> Benzoate + Ammonia" YES "Arginine and proline metabolism; Phenylalanine metabolism; Tryptophan metabolism" pathway from kegg H1175 "Arginine and proline metabolism;Phenylalanine metabolism;Tryptophan metabolism" NAD salvage pathway Arachidonic acid metabolism "Arginine and proline metabolism;path:map00330;Phenylalanine metabolism;path:map00360;Tryptophan metabolism;path:map00380;Aminobenzoate degradation;path:map00627;Styrene degradation;path:map00643;Microbial metabolism in diverse environments;path:map01120" +374 YDR248C "Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1" 2.7.1.12 Putative gluconokinase 2.7.1.12 Probable gluconokinase (EC 2.7.1.12) (Gluconate kinase) gluconokinase 2.7.1.12 putative gluconokinase "D-gluconate + ATP => 6-phospho-D-gluconate + ADP + H(+);6-phospho-D-gluconate + ADP + H(+) => D-gluconate + ATP" "ATP + D-gluconate = ADP + 6-phospho-D-gluconate;ATP + a protein = ADP + a phosphoprotein" "D-gluconate + ATP => 6-phospho-D-gluconate + ADP + H(+);6-phospho-D-gluconate + ADP + H(+) => D-gluconate + ATP" "ATP + D-gluconate = ADP + 6-phospho-D-gluconate;ATP + a protein = ADP + a phosphoprotein" ATP + D-gluconate => D-gluconate 6-phosphate + ADP + H+ ATP + D-Gluconic acid <=> ADP + 6-Phospho-D-gluconate 3 out of 5 ATP + D-gluconate = ADP + 6-phospho-D-gluconate. D-gluconate + ATP <=> 6-phospho-D-gluconate + ADP + H(+) YES Pentose phosphate pathway "pathway from kegg; reaction from rhea" E577 "PATHWAY: Carbohydrate acid metabolism; D-gluconate degradation." "Pentose phosphate pathway;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism" D-gluconate degradation "Pentose phosphate pathway;path:map00030;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" cytoplasm "vacuole;cytoplasm" cytoplasm +377 YDR270W "Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant" 3.6.3.54 Cu(+2)-transporting P-type ATPase Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles. 3.6.3.54 Copper-transporting ATPase (EC 3.6.3.54) (Cu(2+)-ATPase) "CCC2; Cu(2+)-transporting P-type ATPase CCC2" 3.6.3.54 Cross-Complements Ca(2+) phenotype of csg1 ATP7B transports cytosolic Cu2+ to Golgi lumen "ATP + Cu(+)(in) + H2O => ADP + Cu(+)(out) + H(+) + phosphate;ADP + Cu(+)(out) + H(+) + phosphate => ATP + Cu(+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Cu+[side 1] = ADP + phosphate + Cu+[side 2];ATP + a protein = ADP + a phosphoprotein" "ATP + Cu(+)(in) + H2O => ADP + Cu(+)(out) + H(+) + phosphate;ADP + Cu(+)(out) + H(+) + phosphate => ATP + Cu(+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Cu+[side 1] = ADP + phosphate + Cu+[side 2];ATP + a protein = ADP + a phosphoprotein" Cu2+[in] + ATP + H2O => Cu2+[out] + ADP + phosphate + H+ ATP + H2O <=> ADP + Orthophosphate ATP7B transports cytosolic Cu2+ to Golgi lumen 5 out of 5 ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2). Cu2+[in] + ATP + H2O => Cu2+[out] + ADP + phosphate + H+ YES Cu2+ transport pathway from reactome "E521;E586" Ion transport by P-type ATPases NA Golgi "Golgi;cell envelope" Golgi +383 YDR307W "Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation" 2.4.1.109 Putative protein mannosyltransferase similar to Pmt1p Probable protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. {ECO:0000250|UniProtKB:P33775}. 2.4.1.109 Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7 (EC 2.4.1.109) "PMT7; putative dolichyl-phosphate-mannose--protein mannosyltransferase" 2.4.1.109 PMT7 "[protein]-L-serine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => [protein]-L-serine + dolichyl beta-D-mannosyl phosphate;[protein]-L-threonine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+) => [protein]-L-threonine + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + alpha-D-Man-1-Ser/Thr;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein];dolichyl beta-D-mannosyl phosphate + [protein]-(L-serine/L-threonine) = dolichyl phosphate + [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+;dolichyl phosphate D-mannose + protein AN5660 = dolichyl phosphate + O-D-mannosylprotein;dolichyl phosphate D-mannose + alpha-dystroglycan = dolichyl phosphate + O-D-mannosyl-[alpha-dystroglycan];dolichyl phosphate D-mannose + protein Aga2 = dolichyl phosphate + O-D-mannosylprotein Aga2;dolichyl phosphate D-mannose + protein Bar1 = dolichyl phosphate + O-D-mannosylprotein Bar1;dolichyl phosphate D-mannose + protein chitinase 1 = dolichyl phosphate + O-D-mannosylprotein chitinase 1;dolichyl phosphate D-mannose + protein Ggp1/Gas1 = dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1;dolichyl phosphate D-mannose + protein Kex2 = dolichyl phosphate + O-D-mannosylprotein Kex2;dolichyl phosphate D-mannose + protein Kre9 = dolichyl phosphate + O-D-mannosylprotein Kre9;dolichyl phosphate D-mannose + protein Pir2/hsp150 = dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150;dolichyl phosphate D-mannose + ribonuclease 2 = dolichyl phosphate + ribonuclease 2-D-mannose;dolichyl phosphate D-mannose + glucoamylase I = dolichyl phosphate + O-D-mannosyl glucoamylase I;dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein" "[protein]-L-serine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => [protein]-L-serine + dolichyl beta-D-mannosyl phosphate;[protein]-L-threonine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+) => [protein]-L-threonine + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + alpha-D-Man-1-Ser/Thr;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein];dolichyl beta-D-mannosyl phosphate + [protein]-(L-serine/L-threonine) = dolichyl phosphate + [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+;dolichyl phosphate D-mannose + protein AN5660 = dolichyl phosphate + O-D-mannosylprotein;dolichyl phosphate D-mannose + alpha-dystroglycan = dolichyl phosphate + O-D-mannosyl-[alpha-dystroglycan];dolichyl phosphate D-mannose + protein Aga2 = dolichyl phosphate + O-D-mannosylprotein Aga2;dolichyl phosphate D-mannose + protein Bar1 = dolichyl phosphate + O-D-mannosylprotein Bar1;dolichyl phosphate D-mannose + protein chitinase 1 = dolichyl phosphate + O-D-mannosylprotein chitinase 1;dolichyl phosphate D-mannose + protein Ggp1/Gas1 = dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1;dolichyl phosphate D-mannose + protein Kex2 = dolichyl phosphate + O-D-mannosylprotein Kex2;dolichyl phosphate D-mannose + protein Kre9 = dolichyl phosphate + O-D-mannosylprotein Kre9;dolichyl phosphate D-mannose + protein Pir2/hsp150 = dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150;dolichyl phosphate D-mannose + ribonuclease 2 = dolichyl phosphate + ribonuclease 2-D-mannose;dolichyl phosphate D-mannose + glucoamylase I = dolichyl phosphate + O-D-mannosyl glucoamylase I;dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein" a dolichyl beta-D-mannosyl phosphate + a [protein]-(L-serine/L-threonine) => a dolichyl phosphate + a [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+ "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + G13027;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein]" 3 out of 5 Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein. {ECO:0000250|UniProtKB:P33775}. "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + G13027;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein]" YES Mannose type O-glycan biosynthesis "pathway from kegg; ; reaction from kegg; dolp_L[c] + M02645[c] <=> dolmanp_L[c] + Ser_Gly_Ala_X_Gly[c] from recon3" H1179 "PATHWAY: Protein modification; protein glycosylation. {ECO:0000305}." "Other types of O-glycan biosynthesis;Mannose type O-glycan biosynthesis;Metabolic pathways" protein O-mannosylation I (yeast) "Other types of O-glycan biosynthesis;path:map00514;Mannose type O-glycan biosynthesis;path:map00515;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +386 YDR352W "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter" Putative vacuolar membrane transporter for cationic amino acids May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. {ECO:0000269|PubMed:23169667}. Probable vacuolar amino acid transporter YPQ2 (PQ-loop repeat-containing protein 2) "YPQ2; Ypq2p" Yeast PQ-loop protein PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 4 out of 5 NA " L-Arg <=> L-Arg; L-His <=> L-His; L-Lys <=> L-Lys" YES "L-Arg transport (from lysosomal lumen to cytosol); L-His transport (from lysosomal lumen to cytosol); L-Lys transport (from lysosomal lumen to cytosol)" cationic amino acids transport Miscellaneous transport and binding events NA vacuolar membrane "vacuole;vacuolar membrane" vacuolar membrane +387 YDR371W "Putative chitinase; functionally complements A. gossypii cts2 mutant sporulation defect" 3.2.1.14 Putative chitinase 3.2.1.14 Sporulation-specific chitinase 2 (EC 3.2.1.14) "CTS2; putative chitinase" 3.2.1.14 ChiTinaSe "CHIA hydrolyses chitin;CHIT1 hydrolyses CHIT to 3xADGP;Exocytosis of tertiary granule lumen proteins;Exocytosis of tertiary granule lumen proteins;Exocytosis of specific granule lumen proteins;Exocytosis of specific granule lumen proteins;Exocytosis of specific granule lumen proteins;Exocytosis of specific granule lumen proteins" "GlcNAc beta(1-4)GlcNAc + H2O = N-acetyl-D-glucosamine + N-acetyl-D-glucosamine;Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin;beta-1,4-Poly-N-acetyl-D-glucosamine(n+2) + H2O <=> Chitobiose + beta-1,4-Poly-N-acetyl-D-glucosamine(n);N,N',N'',N''',N''''-pentaacetylchitopentaose + H2O = N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;solid beta-chitin + H2O = N,N'-diacetylchitobiose;N-acetylglucosamine oligomers + H2O = N-acetylglucosamine;chitosan + H2O = chitosan oligosaccharides;chitopentaose + H2O = chitobiose + chitotriose" "GlcNAc beta(1-4)GlcNAc + H2O = N-acetyl-D-glucosamine + N-acetyl-D-glucosamine;Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin;beta-1,4-Poly-N-acetyl-D-glucosamine(n+2) + H2O <=> Chitobiose + beta-1,4-Poly-N-acetyl-D-glucosamine(n);N,N',N'',N''',N''''-pentaacetylchitopentaose + H2O = N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;solid beta-chitin + H2O = N,N'-diacetylchitobiose;N-acetylglucosamine oligomers + H2O = N-acetylglucosamine;chitosan + H2O = chitosan oligosaccharides;chitopentaose + H2O = chitobiose + chitotriose" "a chitodextrin + n H2O => n N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;chitin + H2O => 2 a chitodextrin" "Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin" 3 out of 5 Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. "Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin" YES Amino sugar and nucleotide sugar metabolism "pathway from kegg; human model: 2 h2o[c] + Chitin[c] -> 3 N-Acetyl-D-Glucosamine[c]" "H142;H1198" "Amino sugar and nucleotide sugar metabolism;Metabolic pathways" "Digestion of dietary carbohydrate;Neutrophil degranulation" "Amino sugar and nucleotide sugar metabolism;path:map00520;Metabolic pathways;path:map01100" "extracellular;cytoplasm" +388 YDR387C "Putative transporter; member of the sugar porter family; non-essential gene; overexpression results in elevated colony sectoring, an indicator of chromosomal instability" Putative transporter Probable metabolite transport protein YDR387C "CIN10; Cin10p" YDR387C "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;HMIT co-transports myo-inositol with a proton;AP-2 directly binds some endocytic cargo" "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;SLC2A6,8,10,12 transport Glc from extracellular region to cytosol;HMIT co-transports myo-inositol with a proton;AP-2 directly binds some endocytic cargo" 3 out of 5 NA "Glc <=> Glc; myo-inositol <=> myo-inositol" YES Glc transport my-inositol transport is not sure, only shown in reactome database. "Cellular hexose transport;Inositol transporters;Cargo recognition for clathrin-mediated endocytosis" NA "vacuole;cell envelope" +389 YDR404C "RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation" RNA polymerase II subunit B16 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II. {ECO:0000269|PubMed:11087726, ECO:0000269|PubMed:15304220, ECO:0000269|PubMed:17875743}. DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (B16) "RPB7; DNA-directed RNA polymerase II subunit RPB7" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA "nucleus;cytoplasm" "nucleus;cytoplasm" "nucleus;cytoplasm" +390 YDR410C "Farnesyl cysteine-carboxyl methyltransferase; mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane" 2.1.1.100 Farnesyl cysteine-carboxyl methyltransferase Mediates C-terminal methylation of the isoprenylated C-terminal cysteine in A-factor mating pheromone and Ras proteins. {ECO:0000269|PubMed:8289819}. 2.1.1.100 Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT) "STE14; protein-S-isoprenylcysteine carboxyl O-methyltransferase" 2.1.1.100 STErile ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins "S-adenosyl-L-methionine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine => S-adenosyl-L-homocysteine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester;S-adenosyl-L-homocysteine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester => S-adenosyl-L-methionine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine" "S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester;[protein] C-terminal S-farnesyl-L-cysteine + S-adenosyl-L-methionine = [protein] C-terminal S-farnesyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester;S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester;S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester" "S-adenosyl-L-methionine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine => S-adenosyl-L-homocysteine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester;S-adenosyl-L-homocysteine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester => S-adenosyl-L-methionine + [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine" "S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester;[protein] C-terminal S-farnesyl-L-cysteine + S-adenosyl-L-methionine = [protein] C-terminal S-farnesyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester;S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester;S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester" a [protein] C-terminal S-farnesyl-L-cysteine + S-adenosyl-L-methionine => a [protein] C-terminal S-farnesyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine S-Adenosyl-L-methionine + Protein C-terminal S-farnesyl-L-cysteine <=> S-Adenosyl-L-homocysteine + Protein C-terminal S-farnesyl-L-cysteine methyl ester NA 4 out of 5 S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. S-Adenosyl-L-methionine + Protein C-terminal S-farnesyl-L-cysteine <=> S-Adenosyl-L-homocysteine + Protein C-terminal S-farnesyl-L-cysteine methyl ester YES Terpenoid backbone biosynthesis pathway from kegg H1124 NA NA "Terpenoid backbone biosynthesis;Biosynthesis of antibiotics" NA Gamma carboxylation, hypusine formation and arylsulfatase activation "Terpenoid backbone biosynthesis;path:map00900;Biosynthesis of antibiotics;path:map01130" "nucleus;endoplasmic reticulum;endoplasmic reticulum membrane" +391 YDR419W "DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV" 2.7.7.7 DNA polymerase eta DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O(6)-methylguanine, 7,8-dihydro-8-oxoguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts. {ECO:0000269|PubMed:10347143, ECO:0000269|PubMed:10601233, ECO:0000269|PubMed:10713149, ECO:0000269|PubMed:10725365, ECO:0000269|PubMed:10924462, ECO:0000269|PubMed:10932195, ECO:0000269|PubMed:11027270, ECO:0000269|PubMed:11054429, ECO:0000269|PubMed:11062246, ECO:0000269|PubMed:11113193, ECO:0000269|PubMed:11238937, ECO:0000269|PubMed:11545742, ECO:0000269|PubMed:11861920, ECO:0000269|PubMed:12110599, ECO:0000269|PubMed:12665597, ECO:0000269|PubMed:12692307, ECO:0000269|PubMed:12888515, ECO:0000269|PubMed:12899630, ECO:0000269|PubMed:14527996, ECO:0000269|PubMed:15024063, ECO:0000269|PubMed:15157108, ECO:0000269|PubMed:15284331, ECO:0000269|PubMed:15333698, ECO:0000269|PubMed:15520252, ECO:0000269|PubMed:15544332, ECO:0000269|PubMed:15743815, ECO:0000269|PubMed:15779911, ECO:0000269|PubMed:16181813, ECO:0000269|PubMed:16366567, ECO:0000269|PubMed:16387871, ECO:0000269|PubMed:16415180, ECO:0000269|PubMed:16866379, ECO:0000269|PubMed:9409821, ECO:0000269|PubMed:9974380}. 2.7.7.7 DNA polymerase eta (EC 2.7.7.7) (Radiation-sensitive protein 30) "RAD30, DBH1; DNA-directed DNA polymerase eta" 2.7.7.7 RADiation sensitive "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication involved in translesion synthesis during post-replication repair H1117 "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus "nucleus;mitochondrion" nucleus +394 YDR437W "Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis; shares similarity with mammalian PIG-P" 2.4.1.198 Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Involved in cell wall biosynthesis. {ECO:0000269|PubMed:16278447}. 2.4.1.198 Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19 (GPI-GlcNAc transferase complex subunit GPI19) (GPI-GnT subunit GPI19) (EC 2.4.1.198) "GPI19; phosphatidylinositol N-acetylglucosaminyltransferase GPI19" Glycosyl PhosphatidylInositol anchor biosynthesis "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" an L-1-phosphatidyl-inositol + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H+ UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 4 out of 5 UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol. UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES lycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H479;H1129" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;path:map00563;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "nucleus;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +395 YDR440W "Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response" 2.1.1.43 Nucleosomal histone H3-Lys79 methylase Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro). {ECO:0000269|PubMed:11029058, ECO:0000269|PubMed:12097318, ECO:0000269|PubMed:12152067, ECO:0000269|PubMed:12574507, ECO:0000269|PubMed:15292170, ECO:0000269|PubMed:15632126, ECO:0000269|PubMed:16166626, ECO:0000269|PubMed:9755194}. 2.1.1.43 Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Disrupter of telomere silencing protein 1) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) "DOT1, KMT4, PCH1; histone methyltransferase DOT1" 2.1.1.43 Disruptor Of Telomeric silencing "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79);DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79);DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)" "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" a [histone]-L-lysine + S-adenosyl-L-methionine => a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+ "Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine;S-Adenosyl-L-methionine + Histone-L-lysine <=> S-Adenosyl-L-homocysteine + Histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine" 5 out of 5 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. {ECO:0000255|PROSITE-ProRule:PRU00902, ECO:0000269|PubMed:12080090, ECO:0000269|PubMed:12086673, ECO:0000269|PubMed:15292170}. S-adenosyl-L-methionine + L-lysine-[histone] <=> S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone] YES Lysine metabolism "pathway from kegg; reaction from uniprot; Lysine degradation was changed into lysine metabolism based on yeast 7.7" "H372;H974" Lysine degradation PKMTs methylate histone lysines "Lysine degradation;path:map00310" nucleus nucleus nucleus +396 YDR441C "Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication" 2.4.2.7 Potential adenine phosphoribosyltransferase Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. May lack catalytic activity. 2.4.2.7 Adenine phosphoribosyltransferase 2 (APRT 2) (EC 2.4.2.7) "APT2; adenine phosphoribosyltransferase APT2" 2.4.2.7 adenine phosphoribosyltransferase "Exocytosis of secretory granule lumen proteins;Exocytosis of secretory granule lumen proteins;Adenine + PRPP => AMP + PPi" "AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine;5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate" "AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate;5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate = 5-amino-4-imidazolecarboxamide ribotide + diphosphate;5-phospho-alpha-D-ribose 1-diphosphate + guanine = GMP + diphosphate" "AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine;5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate" "AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate;5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate = 5-amino-4-imidazolecarboxamide ribotide + diphosphate;5-phospho-alpha-D-ribose 1-diphosphate + guanine = GMP + diphosphate" 5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate "AMP + Diphosphate <=> Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate;GMP + Diphosphate <=> Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate;1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Diphosphate <=> 5-Amino-4-imidazolecarboxyamide + 5-Phospho-alpha-D-ribose 1-diphosphate" Adenine + PRPP => AMP + PPi 3 out of 5 AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. 5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate YES Purine metabolism pathway from kegg "E227;E613;H62" "PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1." "Purine metabolism;Metabolic pathways" superpathway of purine nucleosides salvage // salvage pathways of adenine, hypoxanthine and their nucleosides // adenine and adenosine salvage IV "Neutrophil degranulation;Purine salvage" "Purine metabolism;path:map00230;Metabolic pathways;path:map01100" cytoplasm cytoplasm cytoplasm +397 YDR452W "Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress" "3.6.1.10;3.6.1.11" Dual endo- and exopolyphosphatase with a role in phosphate metabolism Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths both by cleaving phosphate from the chain end and by fragmenting long-chain polymers into shorter ones. The limited digestion products are 1 and 3 P(i) residues (PubMed:11102525, PubMed:11447286, PubMed:15170373, PubMed:15342119, PubMed:15792812, PubMed:8900207, Ref.16). Also releases phosphate from dATP. dATP phosphohydrolase activity is about 7-fold lower than the exopolyphosphatase activity (Ref.16). {ECO:0000269|PubMed:11102525, ECO:0000269|PubMed:11447286, ECO:0000269|PubMed:15170373, ECO:0000269|PubMed:15342119, ECO:0000269|PubMed:15792812, ECO:0000269|PubMed:8900207, ECO:0000269|Ref.16}. "3.6.1.10; 3.6.1.-; 3.6.1.11" Endopolyphosphatase (EC 3.6.1.10) (Deoxyadenosine triphosphate phosphohydrolase) (dATP phosphohydrolase) (EC 3.6.1.-) (Exopolyphosphatase) (EC 3.6.1.11) (Phosphate metabolism protein 5) "PPN1, PHM5; endopolyphosphatase" 3.6.1.10 PPN1 Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) "n H2O + polyphosphaten+1 => n H(+) + (n+1) phosphate;n H(+) + (n+1) phosphate => n H2O + polyphosphaten+1;H2O + polyphosphaten => H(+) + phosphate + polyphosphaten-1;H(+) + phosphate + polyphosphaten-1 => H2O + polyphosphaten" "polyphosphate + n H2O = (n+1) oligophosphate;(polyphosphate)n + H2O = (polyphosphate)n-1 + phosphate;guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;inosine tetraphosphate + H2O = ITP + phosphate" "n H2O + polyphosphaten+1 => n H(+) + (n+1) phosphate;n H(+) + (n+1) phosphate => n H2O + polyphosphaten+1;H2O + polyphosphaten => H(+) + phosphate + polyphosphaten-1;H(+) + phosphate + polyphosphaten-1 => H2O + polyphosphaten" "polyphosphate + n H2O = (n+1) oligophosphate;(polyphosphate)n + H2O = (polyphosphate)n-1 + phosphate;guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate;5'-dGMP + H2O = deoxyguanosine + phosphate;inosine tetraphosphate + H2O = ITP + phosphate" (polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate NA Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) 5 out of 5 "Polyphosphate + n H(2)O = (n+1) oligophosphate. {ECO:0000269|PubMed:15792812}.; (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate. {ECO:0000269|PubMed:15170373}.; dATP + H(2)O = dADP + phosphate. {ECO:0000269|Ref.16}." "Polyphosphate + n H(2)O <=> (n+1) oligophosphate; (Polyphosphate)(n) + H(2)O <=> (polyphosphate)(n-1) + phosphate; dATP + H(2)O <=> dADP + phosphate" YES other The choose reactions should be: Polyphosphate + n H(2)O <=> (n+1) oligophosphate "NA;NA;NA" NA NA NA NA Glycosphingolipid metabolism "NA;NA;NA" "vacuolar membrane;cytoplasm" "vacuole;nucleus;cytoplasm;vacuolar membrane" "vacuolar membrane;cytoplasm" +398 YDR456W "Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism" Na+/H+ and K+/H+ exchanger Endosomal/prevacuolar electroneutral Na(+)/H(+) exchanger which mediates intracellular sequestration of Na(+) cations, regulates vacuolar pH and contributes to osmotolerance following sudden exposure to hyperosmotic media. Contributes also to the postdiauxic/stationary phase resistance to osmotic stress and allows for the continued growth of cells until the acquired osmotolerance response can occur. Involved in hygromycin resistance probably through its influence on the electrochemical proton gradient affecting secondarily the entrance of hygromycin. Mediates pH-dependent vesicle trafficking out of the endosome. Contributes to K(+) sequestration and homeostasis. {ECO:0000269|PubMed:10589731, ECO:0000269|PubMed:10998367, ECO:0000269|PubMed:11102523, ECO:0000269|PubMed:14610088, ECO:0000269|PubMed:1493335, ECO:0000269|PubMed:15635088, ECO:0000269|PubMed:15659172, ECO:0000269|PubMed:16671892, ECO:0000269|PubMed:17588950, ECO:0000269|PubMed:18378800, ECO:0000269|PubMed:18799619, ECO:0000269|PubMed:9334180, ECO:0000269|PubMed:9694857}. Endosomal/prevacuolar sodium/hydrogen exchanger (Endosomal/prevacuolar Na(+)/H(+) exchanger) (Vacuolar protein sorting-associated protein 44) "NHX1, NHA2, VPL27, VPS44; bifunctional K:H/Na:H antiporter NHX1" Na+/H+ eXchanger "SLC9A9 exchanges Na+ for H+ across the late endosome membrane;SLC9A6,7 exchange Na+ for H+ across the early endosome membrane;Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at trans-golgi membrane);Na+/H+ exchanger transport (at trans-golgi membrane)" "SLC9A9 exchanges Na+ for H+ across the late endosome membrane;SLC9A6,7 exchange Na+ for H+ across the early endosome membrane;Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at cell membrane);Na+/H+ exchanger transport (at trans-golgi membrane);Na+/H+ exchanger transport (at trans-golgi membrane)" 5 out of 5 NA "Na+ (out) + H+ (in) <=> Na+ (in) + H+ (out); K+ (out) + H+ (in) <=> K+ (in) + H+ (out)" YES "Na+/H+ exchanger transport; K+/H+ exchanger transport" Sodium/Proton exchangers NA cytoplasm "vacuole;cytoplasm;endoplasmic reticulum;Golgi" cytoplasm +406 YDR516C "Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" 2.7.1.2 Non-essential protein of unknown function Putative glucokinase involved in phosphorylation of aldohexoses and glucose uptake (By similarity). Involved in sporulation. Required for the full activation of the early meiotic inducer IME1. {ECO:0000250, ECO:0000269|PubMed:12586695}. 2.7.1.2 Putative glucokinase-2 (EC 2.7.1.2) (Early meiotic induction protein 2) (Glucose kinase 2) (GLK-2) "EMI2; putative glucokinase" 2.7.1.1 putative glucokinase-2 "glucokinase [nucleoplasm] => glucokinase [cytosol];glucokinase [nucleoplasm] => glucokinase [cytosol];Exocytosis of secretory granule lumen proteins;Exocytosis of secretory granule lumen proteins;Exocytosis of ficolin-rich granule lumen proteins;Exocytosis of ficolin-rich granule lumen proteins;HK1,2,3,GCK phosphorylate Glc to form G6P;HK1,2,3,GCK phosphorylate Glc to form G6P;HK1,2,3,GCK phosphorylate Glc to form G6P" "D-glucose + ATP => D-glucose 6-phosphate + ADP + H(+);D-glucose 6-phosphate + ADP + H(+) => D-glucose + ATP" "ATP + H2O = ADP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate;ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate;ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate;ATP + D-fructose = ADP + D-fructose 6-phosphate;ATP + D-mannose = ADP + D-mannose 6-phosphate;ITP + D-glucose = IDP + D-glucose 6-phosphate;2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate;ATP + beta-D-glucose = ADP + beta-D-glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate" "D-glucose + ATP => D-glucose 6-phosphate + ADP + H(+);D-glucose 6-phosphate + ADP + H(+) => D-glucose + ATP" "ATP + H2O = ADP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate;ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate;ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate;ATP + D-fructose = ADP + D-fructose 6-phosphate;ATP + D-mannose = ADP + D-mannose 6-phosphate;ITP + D-glucose = IDP + D-glucose 6-phosphate;2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate;ATP + beta-D-glucose = ADP + beta-D-glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate" D-glucopyranose + ATP => D-glucopyranose 6-phosphate + ADP + H+ "ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate;ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ATP + D-Mannose <=> ADP + D-Mannose 6-phosphate;ATP + beta-D-Glucose <=> ADP + beta-D-Glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate;ATP + D-Glucosamine <=> ADP + D-Glucosamine 6-phosphate;ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate" "glucokinase [nucleoplasm] => glucokinase [cytosol];glucokinase [nucleoplasm] => glucokinase [cytosol];HK1,2,3,GCK phosphorylate Glc to form G6P" 4 out of 5 ATP + D-glucose = ADP + D-glucose 6-phosphate. ATP + D-glucose <=> ADP + D-glucose 6-phosphate YES Glycolysis / Gluconeogenesis pathway from kegg "E388;H1171" "Glycolysis / Gluconeogenesis;Fructose and mannose metabolism;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism" chitin biosynthesis // sucrose degradation III (sucrose invertase) // glycolysis III (from glucose) // trehalose degradation II (trehalase) // glucose-6-phosphate biosynthesis "Regulation of Glucokinase by Glucokinase Regulatory Protein;Neutrophil degranulation;Glycolysis" "Glycolysis / Gluconeogenesis;path:map00010;Galactose metabolism;path:map00052;Starch and sucrose metabolism;path:map00500;Amino sugar and nucleotide sugar metabolism;path:map00520;Streptomycin biosynthesis;path:map00521;Neomycin, kanamycin and gentamicin biosynthesis;path:map00524;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" cytoplasm cytoplasm cytoplasm +410 YDR533C "Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress" 4.2.1.130 Methylglyoxalase that converts methylglyoxal to D-lactate Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals (PubMed:24302734). Involved in protection against reactive oxygen species (ROS) (PubMed:17395014). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893). {ECO:0000269|PubMed:17395014, ECO:0000269|PubMed:24302734, ECO:0000269|PubMed:24706893}. 4.2.1.130 Glutathione-independent glyoxalase HSP31 (EC 4.2.1.130) (Glyoxalase 3 homolog 1) (Heat shock protein 31) "HSP31; glutathione-independent methylglyoxalase" Heat-Shock Protein "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O 5 out of 5 (R)-lactate = methylglyoxal + H(2)O. {ECO:0000269|PubMed:24302734, ECO:0000269|PubMed:24758716}. (R)-lactate <=> methylglyoxal + H2O YES Methylglyoxal Metabolism pathway from e.coli model E513 "Pyruvate metabolism;path:map00620;Microbial metabolism in diverse environments;path:map01120" cytoplasm cytoplasm cytoplasm +412 YGL006W "Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a" 3.6.3.8 Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium. 3.6.3.8 Calcium-transporting ATPase 2 (EC 3.6.3.8) (Vacuolar Ca(2+)-ATPase) "PMC1; calcium-transporting ATPase PMC1" 3.6.3.8 Plasma Membrane Calcium "ATP2B1-4 transport cytosolic Ca2+ to extracellular region;ATP2B1-4 transport cytosolic Ca2+ to extracellular region;ATP2B1-4 transport cytosolic Ca2+ to extracellular region;ATP2B1-4 transport cytosolic Ca2+ to extracellular region;ATP2B4 binds to NOS1, inhibiting it" "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate;ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2];ATP + H2O + 2 Ca2+[cytoplasm side] = ADP + phosphate + 2 Ca2+[lumen side]" "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate;ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2];ATP + H2O + 2 Ca2+[cytoplasm side] = ADP + phosphate + 2 Ca2+[lumen side]" Ca2+[out] + ATP + H2O = Ca2+[in] + ADP + phosphate + H+ 4 out of 5 ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). Ca2+[out] + ATP + H2O <=> Ca2+[in] + ADP + phosphate + H+ YES Ca2+ transport pathway from reactome E586 "Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases" NA vacuolar membrane "vacuole;vacuolar membrane;cell envelope" vacuolar membrane +414 YGL017W "Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway" 2.3.2.8 Arginyl-tRNA-protein transferase Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). {ECO:0000250}. 2.3.2.8 Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) "ATE1; arginyltransferase" 2.3.2.8 arginyl-tRNA-protein transferase "L-arginyl-tRNA(Arg) + a [protein] N-terminus => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg);H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => L-arginyl-tRNA(Arg) + a [protein] N-terminus" "L-Arginyl-tRNA(Arg) + Protein <=> tRNA(Arg) + L-Arginyl-protein;L-arginyl-[tRNAarg] + protein = tRNAarg + N-terminal arginyl-[protein];L-arginyl-[tRNAarg] + N-terminal L-glutamyl-[protein] = tRNAarg + N-terminal L-arginiyl-L-glutamyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal L-aspartyl-[protein] = tRNAarg + N-terminal L-arginiyl-L-aspartyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal 3-sulfino-L-alanyl-[protein] = tRNAarg + N-terminal L-arginiyl-3-sulfino-L-alanyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal 3-sulfo-L-alanyl-[protein] = tRNAarg + N-terminal L-arginiyl-3-sulfo-L-alanyl-[protein] + H+;L-arginyl-tRNAArg + calreticulin = tRNAArg + L-arginyl-[calreticulin];L-arginyl-tRNAArg + protein disulfide isomerase = tRNAArg + L-arginyl-[protein disulfide isomerase];L-arginyl-tRNAArg + BiP/GRP78 protein = tRNAArg + L-arginyl-[BiP/GRP78 protein];L-arginyl-tRNAArg + acceptor protein = tRNAArg + L-arginyl-[acceptor protein];L-Arg-tRNA + apolipoprotein A-I = tRNAArg + L-Arg-[apolipoprotein A-I];L-Arg-tRNAArg + alpha-1-antitrypsin = tRNAArg + L-Arg-[alpha-1-antitrypsin];L-Arg-tRNAArg + apolipoprotein E = tRNAArg + L-Arg-[apolipoprotein E];L-Arg-tRNAArg + calreticulin = tRNAArg + L-Arg-[calreticulin];L-Arg-tRNAArg + protein-disulfide isomerase = tRNAArg + L-Arg-[protein-disulfide isomerase];L-Arg-tRNAArg + hemopexin = tRNAArg + L-Arg-[hemopexin];L-Arg-tRNAArg + contrapsin-like protease inhibitor-3 = tRNAArg + L-Arg-[contrapsin-like protease inhibitor-3];L-Arg-tRNAArg + glucose-related protein 78 = tRNAArg + L-Arg-[glucose-related protein 78];L-arginyl-tRNAArg + protein = tRNAArg + L-arginyl-[protein]" "L-arginyl-tRNA(Arg) + a [protein] N-terminus => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg);H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => L-arginyl-tRNA(Arg) + a [protein] N-terminus" "L-Arginyl-tRNA(Arg) + Protein <=> tRNA(Arg) + L-Arginyl-protein;L-arginyl-[tRNAarg] + protein = tRNAarg + N-terminal arginyl-[protein];L-arginyl-[tRNAarg] + N-terminal L-glutamyl-[protein] = tRNAarg + N-terminal L-arginiyl-L-glutamyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal L-aspartyl-[protein] = tRNAarg + N-terminal L-arginiyl-L-aspartyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal 3-sulfino-L-alanyl-[protein] = tRNAarg + N-terminal L-arginiyl-3-sulfino-L-alanyl-[protein] + H+;L-arginyl-[tRNAarg] + N-terminal 3-sulfo-L-alanyl-[protein] = tRNAarg + N-terminal L-arginiyl-3-sulfo-L-alanyl-[protein] + H+;L-arginyl-tRNAArg + calreticulin = tRNAArg + L-arginyl-[calreticulin];L-arginyl-tRNAArg + protein disulfide isomerase = tRNAArg + L-arginyl-[protein disulfide isomerase];L-arginyl-tRNAArg + BiP/GRP78 protein = tRNAArg + L-arginyl-[BiP/GRP78 protein];L-arginyl-tRNAArg + acceptor protein = tRNAArg + L-arginyl-[acceptor protein];L-Arg-tRNA + apolipoprotein A-I = tRNAArg + L-Arg-[apolipoprotein A-I];L-Arg-tRNAArg + alpha-1-antitrypsin = tRNAArg + L-Arg-[alpha-1-antitrypsin];L-Arg-tRNAArg + apolipoprotein E = tRNAArg + L-Arg-[apolipoprotein E];L-Arg-tRNAArg + calreticulin = tRNAArg + L-Arg-[calreticulin];L-Arg-tRNAArg + protein-disulfide isomerase = tRNAArg + L-Arg-[protein-disulfide isomerase];L-Arg-tRNAArg + hemopexin = tRNAArg + L-Arg-[hemopexin];L-Arg-tRNAArg + contrapsin-like protease inhibitor-3 = tRNAArg + L-Arg-[contrapsin-like protease inhibitor-3];L-Arg-tRNAArg + glucose-related protein 78 = tRNAArg + L-Arg-[glucose-related protein 78];L-arginyl-tRNAArg + protein = tRNAArg + L-arginyl-[protein]" a protein + an L-arginyl-[tRNAarg] => a tRNAarg + an N-terminal arginyl-[protein] L-Arginyl-tRNA(Arg) + Protein <=> tRNA(Arg) + L-Arginyl-protein 3 out of 5 L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein]. L-Arginyl-tRNA(Arg) + Protein <=> tRNA(Arg) + L-Arginyl-protein YES other No pathway from database H1249 NA cytoplasm cytoplasm cytoplasm +415 YGL018C "Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix" Specialized J-protein that functions in Fe-S cluster biogenesis Co-chaperone required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Stimulates the ATPase activity of its specialized Hsp70 chaperone partner SSQ1. Binds to the substrate protein ISU1 and targets it to SSQ1. May function together with SSQ1 in the dislocation of the Fe/S cluster from ISU1 and its insertion into apoproteins. {ECO:0000269|PubMed:11171977, ECO:0000269|PubMed:11273703, ECO:0000269|PubMed:11278728, ECO:0000269|PubMed:12756240, ECO:0000269|PubMed:12970193, ECO:0000269|PubMed:15123690, ECO:0000269|PubMed:16431909, ECO:0000269|PubMed:16551614, ECO:0000269|PubMed:9813017}. J-type co-chaperone JAC1, mitochondrial (J-type accessory chaperone 1) "JAC1; J-type chaperone JAC1" co-chaperone for [Fe-S] cluster biosynthesis "TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix;TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix;Precursor proteins enter TIM23 PAM complex;Precursor proteins enter TIM23 PAM complex;MPP hydrolyzes presequence of matrix precursors;Formation of 4Fe-4S cluster on ISCA1:ISCA2" a [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex + an [Fe-S cluster biosynthesis co-chaperone] => a [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + L-cysteine desulfurase 5 out of 5 NA a [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex + an [Fe-S cluster biosynthesis co-chaperone] => a [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + L-cysteine desulfurase YES iron-sulfur cluster biosynthesis pathway from biocyc iron-sulfur cluster biosynthesis Mitochondrial iron-sulfur cluster biogenesis NA mitochondrion mitochondrion mitochondrion +418 YGL022W "Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis" 2.4.99.18 Subunit of the oligosaccharyltransferase complex of the ER lumen Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000269|PubMed:12359722}. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 (Oligosaccharyl transferase subunit STT3) (EC 2.4.99.18) "STT3; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3" 2.4.99.18 oligosaccharyl transferase complex STT3 subunit "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate "Dolichyl diphosphooligosaccharide + Protein asparagine <=> Dolichyl diphosphate + Glycoprotein with the oligosaccharide chain attached by N-glycosyl linkage to protein L-asparagine;Protein asparagine + G00008 <=> Dolichyl diphosphate + G00009" 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. "Dolichyl diphosphooligosaccharide + Protein asparagine <=> Dolichyl diphosphate + Glycoprotein with the oligosaccharide chain attached by N-glycosyl linkage to protein L-asparagine;Protein asparagine + G00008 <=> Dolichyl diphosphate + G00009" YES N-Glycan biosynthesis pathway from kegg "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +419 YGL027C "Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress" 3.2.1.106 Processing alpha glucosidase I Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically (PubMed:9363442). Seems to play a role in beta-1,6-glucan synthesis (PubMed:8576053). {ECO:0000269|PubMed:8576053, ECO:0000269|PubMed:9363442}. 3.2.1.106 Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) (Glucosidase I) "CWH41, DER7, GLS1; Cwh41p" 3.2.1.106 "mannosyl-oligosaccharide 1,2-α-glucosidase" Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase "Glc3Man9GlcNAc2 + H2O = D-glucose + Glc2Man9GlcNAc2;4-methylumbelliferyl-alpha-D-glucoside + H2O = 4-methylumbelliferone + D-glucose;H2O + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;Glc3Man9GlcNAc + H2O = D-glucose + Glc2Man9GlcNAc" "Glc3Man9GlcNAc2 + H2O = D-glucose + Glc2Man9GlcNAc2;4-methylumbelliferyl-alpha-D-glucoside + H2O = 4-methylumbelliferone + D-glucose;H2O + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Glucose + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;Glc3Man9GlcNAc + H2O = D-glucose + Glc2Man9GlcNAc" a [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H2O => a [protein]-L-asparagine-[(glucosyl)2(mannosyl)9(N-acetylglucosaminyl)2] + D-glucopyranose H2O + G00009 <=> D-Glucose + G00171 5 out of 5 Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). {ECO:0000269|PubMed:23536181}. H2O + G00009 <=> D-Glucose + G00171 YES N-Glycan biosynthesis pathway from kegg H393 "PATHWAY: Glycan metabolism; N-glycan degradation. {ECO:0000305}." "N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (yeast) processing in the ER N-glycan trimming in the ER and Calnexin/Calreticulin cycle "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "vacuole;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +420 YGL038C "Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins" 2.4.1.232 Mannosyltransferase of the cis-Golgi apparatus Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates. Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. Has also the potential to transfer a second alpha-1,6-mannose to the Man(8)GlNAc(2) core oligosaccharide. {ECO:0000269|PubMed:1523886, ECO:0000269|PubMed:1628616, ECO:0000269|PubMed:17042779, ECO:0000269|PubMed:21979948, ECO:0000269|PubMed:7649302, ECO:0000269|PubMed:8253757}. 2.4.1.232 Initiation-specific alpha-1,6-mannosyltransferase (EC 2.4.1.232) (Outer chain elongation protein 1) "OCH1, LDB12, NGD29; Och1p" 2.4.1.232 "initiation-specific 1,6-α-mannosyltransferase" "GDP-D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GDP-D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GDP-alpha-D-mannose + lipid-linked D-mannose-oligosaccharide = lipid-linked alpha(1->6)-D-mannosyl-D-mannose-oligosaccharide + GDP;GDP-mannose + Man8GlcNAc = GDP + Man9GlcNAc" "GDP-D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GDP-D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;GDP-alpha-D-mannose + lipid-linked D-mannose-oligosaccharide = lipid-linked alpha(1->6)-D-mannosyl-D-mannose-oligosaccharide + GDP;GDP-mannose + Man8GlcNAc = GDP + Man9GlcNAc" "GDP-alpha-D-mannose + a [protein]-L-asparagine-[(mannosyl)8(N-acetylglucosaminyl)2] => a [protein]-L-asparagine-[(mannosyl)9(N-acetylglucosaminyl)2] + GDP + H+;GDP-alpha-D-mannose + a [protein]-L-asparagine-[(mannosyl)9(N-acetylglucosaminyl)2] => a [protein]-L-asparagine-[(mannosyl)10(N-acetylglucosaminyl)2] + GDP + H+" GDP-D-mannose + G10694 <=> GDP + G01813 5 out of 5 Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage. {ECO:0000269|PubMed:1628616, ECO:0000269|PubMed:17042779}. GDP-D-mannose + G10694 <=> GDP + G01813 YES Various types of N-glycan biosynthesis pathway from kegg "Various types of N-glycan biosynthesis;Metabolic pathways" "Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" "endoplasmic reticulum membrane;Golgi membrane" "Golgi;Golgi membrane;endoplasmic reticulum;endoplasmic reticulum membrane" "Golgi membrane;endoplasmic reticulum membrane" +421 YGL047W "Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress; both human homologs ALG13 and ALG14 are required to complement yeast alg13 mutant" 2.4.1.141 Catalytic component of UDP-GlcNAc transferase Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. {ECO:0000269|PubMed:15615718, ECO:0000269|PubMed:16100110}. 2.4.1.141 UDP-N-acetylglucosamine transferase subunit ALG13 (EC 2.4.1.141) (Asparagine-linked glycosylation protein 13) "ALG13; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13" 2.4.1.141 UDP-N-acetylglucosamine transferase Alg13p subunit "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => N,N'-diacetylchitobiosyl diphosphodolichol + H(+) + UDP;N,N'-diacetylchitobiosyl diphosphodolichol + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol;N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-glucosaminyl-(1rarr4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + H+ + UDP;N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-glucuronic acid = D-glucuronyl-1,4-N-acetyl-D-glucosaminyl-diphosphodolichol + UDP" "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => N,N'-diacetylchitobiosyl diphosphodolichol + H(+) + UDP;N,N'-diacetylchitobiosyl diphosphodolichol + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol;N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-glucosaminyl-(1rarr4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + H+ + UDP;N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-glucuronic acid = D-glucuronyl-1,4-N-acetyl-D-glucosaminyl-diphosphodolichol + UDP" N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP + H+ UDP-N-acetyl-D-glucosamine + N-Acetyl-D-glucosaminyldiphosphodolichol <=> UDP + N,N'-Chitobiosyldiphosphodolichol 5 out of 5 UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol. UDP-N-acetyl-D-glucosamine + N-Acetyl-D-glucosaminyldiphosphodolichol <=> UDP + N,N'-Chitobiosyldiphosphodolichol YES N-Glycan biosynthesis pathway from kegg "H290;H1136" lipid-linked oligosaccharide biosynthesis "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum "nucleus;cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum +426 YGL065C "Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; human ALG2 complements the temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of the alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement" "2.4.1.132;2.4.1.257" Mannosyltransferase in the N-linked glycosylation pathway Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. {ECO:0000269|PubMed:16878994}. "2.4.1.132; 2.4.1.257" Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase) "ALG2; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase" "2.4.1.132;2.4.1.257" ALG2 mannosyltransferase "Addition of a second mannose to the N-glycan precursor by ALG2;Addition of a third mannose to the N-glycan precursor by Alg2" "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+);alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose;alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+);alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose" "GDP-mannose + beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol <=> GDP + alpha-D-Mannosyl-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol;GDP-D-mannose + beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> GDP + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;GDP-alpha-D-mannose + beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr3)-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+;GDPmannose + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol = GDP + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-3)Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol;GDPmannose + tetrasaccharide-diphosphoryl-lipid = GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid;GDP-D-mannose + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> GDP + alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;alpha-D-Man-(1rarr3)-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + H+ + GDP;GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol" "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+);alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose;alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+);alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose" "GDP-mannose + beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol <=> GDP + alpha-D-Mannosyl-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol;GDP-D-mannose + beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> GDP + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;GDP-alpha-D-mannose + beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr3)-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+;GDPmannose + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol = GDP + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-3)Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol;GDPmannose + tetrasaccharide-diphosphoryl-lipid = GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid;GDP-D-mannose + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> GDP + alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;alpha-D-Man-(1rarr3)-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + H+ + GDP;GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol" "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+;beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+" "GDP-D-mannose + G00003 <=> GDP + G00004;GDP-D-mannose + G00004 <=> GDP + G00005" 5 out of 5 "GDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994}.; GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994}." "GDP-D-mannose + G00003 <=> GDP + G00004;GDP-D-mannose + G00004 <=> GDP + G00005" YES N-Glycan biosynthesis pathway from kegg "H247;H1290;NA" lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100;NA" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +427 YGL070C "RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription" RNA polymerase II subunit B12.6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation. Involved in DNA repair of damage in the transcribed strand. Mediates a transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER). {ECO:0000269|PubMed:12411509}. DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (B12.6) (DNA-directed RNA polymerase II 14.2 kDa polypeptide) (DNA-directed RNA polymerase II subunit 9) "RPB9, SSU73; DNA-directed RNA polymerase II core subunit RPB9" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus +431 YGL104C "Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog, YBR241C, that arose from the whole genome duplication" NA Mitochondrial protein May be involved in vacuolar protein sorting. {ECO:0000269|PubMed:12134085}. NA Vacuolar protein sorting-associated protein 73 "VPS73; putative sugar transporter" NA Vacuolar Protein Sorting "SLC2A5 transports fructose from extracellular region to cytosol;SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT7 and GLUT11 transport glucose and fructose;GLUT7 and GLUT11 transport glucose and fructose;SLC2A9 transports Fru, Glc, urate;GLUT1 tetramer binds 4xATP;GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP;GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol;SLC2A1 tetramer transports Glc from cytosol to Golgi lumen;Exocytosis of secretory granule membrane proteins;Exocytosis of secretory granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol;GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol;GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol;GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" NA NA NA NA NA NA "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT1/3 transports extracellular DHvitC to cytosol;GLUT7 and GLUT11 transport glucose and fructose;GLUT7 and GLUT11 transport glucose and fructose;SLC2A9 transports Fru, Glc, urate;GLUT1 tetramer binds 4xATP;GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP;GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2;GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol;SLC2A1 tetramer transports Glc from cytosol to Golgi lumen;Exocytosis of secretory granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of ficolin-rich granule membrane proteins;GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol;GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol;GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol;GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" 3 out of 5 NA " Fru <=> Fru; Gal <=> Gal; Glc <=> Glc" YES hexose transport putative sugar transporter. Not sure NA NA NA NA NA "Cellular hexose transport;Vitamin C (ascorbate) metabolism;Regulation of insulin secretion;Lactose synthesis;Neutrophil degranulation;Intestinal hexose absorption" NA mitochondrial membrane "vacuole;mitochondrion;mitochondrial membrane" mitochondrial membrane +440 YGL156W "Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway" 3.2.1.24 Vacuolar alpha mannosidase Degrades free oligosaccharides in the vacuole. {ECO:0000269|PubMed:12723970}. 3.2.1.24 Alpha-mannosidase (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) "AMS1; alpha-mannosidase" 3.2.1.24 alpha mannosidase MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 "2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;Mannobiose + H2O <=> 2 D-Mannose;alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-D-GlcNAc + H2O <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-D-GlcNAc + D-Mannose;alpha-D-Man-(1->6)-beta-D-Man-(1->4)-D-GlcNAc + H2O <=> beta-D-Man-(1->4)-D-GlcNAc + D-Mannose;alpha-(1-3)-mannobiose + H2O = alpha-D-mannopyranose + D-mannopyranose;alpha-(1-2)-mannobiose + H2O = alpha-D-mannopyranose + D-mannopyranose;alpha-(1-6)-mannobiose = alpha-D-mannopyranose + D-mannopyranose;Manalpha(1-3)GlcNAc + H2O = alpha-D-mannopyranose + N-acetyl-D-glucosamine;Manalpha(1-6)GlcNAc + H2O = alpha-mannopyranose + N-acetyl-D-glucosamine;Man9GlcNAc2 + H2O = Man8GlcNAc2 + mannose;mannotriose + H2O = alpha-D-mannopyranose + mannobiose;mannotetraose + H2O = alpha-D-mannopyranose + mannotriose;Man5GlcNAc2 + H2O = Man4GlcNAc2 + alpha-D-mannopyranose;Man9GlcNAc2 + H2O = Man5-8GlcNAc2 + alpha-D-mannopyranose;Man7GlcNAc + 2 H2O = Man5GlcNAc + 2 alpha-D-mannopyranose;2 Man9GlcNAc + 3 H2O = Man8GlcNAc + Man7GlcNAc + 3 alpha-D-mannopyranose;3-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;Man9-5GlcNAc + 4 H2O = Man5-3GlcNAc + 4 alpha-D-mannopyranose;Manalpha(1-4)Manbeta(1-4)Man + H2O = alpha-D-mannopyranose + Manbeta(1-4)Man;mannosyl rhamnose + H2O = alpha-D-mannopyranose + rhamnose;Man5GlcNAc + 2 H2O = Man3GlcNAc + 2 alpha-D-mannopyranose;GDP-mannosylpyranose + H2O = alpha-D-mannopyranose + GDP;Man8GlcNAc + 3 H2O = Man5GlcNAc + 3 alpha-D-mannopyranose;Man3GlcNAc2 + H2O = Man2GlcNAc2 + alpha-D-mannopyranose;Man8GlcNAc2 + 3 H2O = Man5GlcNAc2 + 3 D-mannose;Man8GlcNAc2 + 3 H2O = Man5GlcNAc2 + 3 alpha-D-mannopyranose;alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O = 6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc;alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + H2O = alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc + alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)-beta-D-Man" "2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;Mannobiose + H2O <=> 2 D-Mannose;alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-D-GlcNAc + H2O <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-D-GlcNAc + D-Mannose;alpha-D-Man-(1->6)-beta-D-Man-(1->4)-D-GlcNAc + H2O <=> beta-D-Man-(1->4)-D-GlcNAc + D-Mannose;alpha-(1-3)-mannobiose + H2O = alpha-D-mannopyranose + D-mannopyranose;alpha-(1-2)-mannobiose + H2O = alpha-D-mannopyranose + D-mannopyranose;alpha-(1-6)-mannobiose = alpha-D-mannopyranose + D-mannopyranose;Manalpha(1-3)GlcNAc + H2O = alpha-D-mannopyranose + N-acetyl-D-glucosamine;Manalpha(1-6)GlcNAc + H2O = alpha-mannopyranose + N-acetyl-D-glucosamine;Man9GlcNAc2 + H2O = Man8GlcNAc2 + mannose;mannotriose + H2O = alpha-D-mannopyranose + mannobiose;mannotetraose + H2O = alpha-D-mannopyranose + mannotriose;Man5GlcNAc2 + H2O = Man4GlcNAc2 + alpha-D-mannopyranose;Man9GlcNAc2 + H2O = Man5-8GlcNAc2 + alpha-D-mannopyranose;Man7GlcNAc + 2 H2O = Man5GlcNAc + 2 alpha-D-mannopyranose;2 Man9GlcNAc + 3 H2O = Man8GlcNAc + Man7GlcNAc + 3 alpha-D-mannopyranose;3-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;Man9-5GlcNAc + 4 H2O = Man5-3GlcNAc + 4 alpha-D-mannopyranose;Manalpha(1-4)Manbeta(1-4)Man + H2O = alpha-D-mannopyranose + Manbeta(1-4)Man;mannosyl rhamnose + H2O = alpha-D-mannopyranose + rhamnose;Man5GlcNAc + 2 H2O = Man3GlcNAc + 2 alpha-D-mannopyranose;GDP-mannosylpyranose + H2O = alpha-D-mannopyranose + GDP;Man8GlcNAc + 3 H2O = Man5GlcNAc + 3 alpha-D-mannopyranose;Man3GlcNAc2 + H2O = Man2GlcNAc2 + alpha-D-mannopyranose;Man8GlcNAc2 + 3 H2O = Man5GlcNAc2 + 3 D-mannose;Man8GlcNAc2 + 3 H2O = Man5GlcNAc2 + 3 alpha-D-mannopyranose;alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O = 6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc;alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + H2O = alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc + alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)-beta-D-Man" "2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H2O => D-mannopyranose 6-phosphate + D-glycerate;an alpha-D-mannoside + H2O => alpha-D-mannopyranose + a non glycosylated sugar acceptor" MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 5 out of 5 Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. "2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H2O => D-mannopyranose 6-phosphate + D-glycerate;an alpha-D-mannoside + H2O => alpha-D-mannopyranose + a non glycosylated sugar acceptor" YES Other glycan degradation pathway from kegg H26 Other glycan degradation Lysosomal oligosaccharide catabolism "Other glycan degradation;path:map00511" vacuole vacuole vacuole +442 YGL167C "High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant" 3.6.3.8 High affinity Ca2+/Mn2+ P-type ATPase This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway. 3.6.3.8 Calcium-transporting ATPase 1 (EC 3.6.3.8) (Bypass SOD defects protein 1) (Golgi Ca(2+)-ATPase) "PMR1, BSD1, LDB1, SSC1; Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1" 3.6.3.8 Plasma Membrane ATPase Related "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen;ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen;ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen;ATP2A1-3 transport Ca2+ from cytosol to ER lumen;ATP2A1-3 transport Ca2+ from cytosol to ER lumen;ATP2A1-3 transport Ca2+ from cytosol to ER lumen;ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen;ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen" "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate;ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2];ATP + H2O + 2 Ca2+[cytoplasm side] = ADP + phosphate + 2 Ca2+[lumen side]" "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate;ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O" "ATP + H2O = ADP + phosphate;ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2];ATP + H2O + 2 Ca2+[cytoplasm side] = ADP + phosphate + 2 Ca2+[lumen side]" Ca2+[out] + ATP + H2O = Ca2+[in] + ADP + phosphate + H+ "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen;ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen" 5 out of 5 ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). Ca2+[out] + ATP + H2O <=> Ca2+[in] + ADP + phosphate + H+ YES "Ca2+ transport; Mg2+ transport" "required for Ca2+ and Mn2+ transport into Golgi; pathway from reactome" E586 "Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases" NA Golgi membrane "Golgi membrane;Golgi;cell envelope" Golgi membrane +443 YGL169W "Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length" 2.7.7.87 Protein involved in threonylcarbamoyl adenosine biosynthesis Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length. {ECO:0000269|PubMed:19287007, ECO:0000269|PubMed:19369944, ECO:0000269|PubMed:19884342, ECO:0000269|PubMed:21183954, ECO:0000269|PubMed:23258706, ECO:0000269|PubMed:23620299}. 2.7.7.87 Threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (Suppressor of upstream AUG protein 5) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein SUA5) (tRNA threonylcarbamoyladenosine biosynthesis protein SUA5) "SUA5; threonylcarbamoyladenylate synthase" 2.7.7.87 Suppressor of Upstream AUG NA "L-threonine + ATP + hydrogencarbonate => L-threonylcarbamoyladenylate + diphosphate + H2O;L-threonylcarbamoyladenylate + diphosphate + H2O => L-threonine + ATP + hydrogencarbonate" "L-threonine + ATP + HCO3- = L-threonylcarbamoyladenylate + diphosphate + H2O;L-threonylcarbamoyl-AMP + tRNA = t6A37-tRNA;L-threonine + ATP + CO2 = L-threonylcarbamoyl-AMP + diphosphate" "L-threonine + ATP + hydrogencarbonate => L-threonylcarbamoyladenylate + diphosphate + H2O;L-threonylcarbamoyladenylate + diphosphate + H2O => L-threonine + ATP + hydrogencarbonate" "L-threonine + ATP + HCO3- = L-threonylcarbamoyladenylate + diphosphate + H2O;L-threonylcarbamoyl-AMP + tRNA = t6A37-tRNA;L-threonine + ATP + CO2 = L-threonylcarbamoyl-AMP + diphosphate" NA L-Threonine + ATP + HCO3- + H+ <=> L-Threonylcarbamoyladenylate + Diphosphate + H2O NA 5 out of 5 L-threonine + ATP + HCO(3)(-) = L-threonylcarbamoyladenylate + diphosphate + H(2)O. {ECO:0000269|PubMed:23620299}. L-Threonine + ATP + HCO3- + H+ <=> L-Threonylcarbamoyladenylate + Diphosphate + H2O YES Other NA NA NA NA NA NA NA NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +450 YGL196W "D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate" 4.3.1.18 D-serine dehydratase (aka D-serine ammonia-lyase) Converts specifically D-serine to pyruvate and ammonia. May play a role in D-serine detoxification. {ECO:0000269|PubMed:17869212, ECO:0000269|PubMed:17937657}. 4.3.1.18 D-serine dehydratase (EC 4.3.1.18) (D-serine deaminase) (DSD) "DSD1; D-serine ammonia-lyase DSD1" 4.3.1.18 DSD1 "D-serine => NH4(+) + pyruvate;NH4(+) + pyruvate => D-serine" "D-Serine = pyruvate + NH3;3-chloro-D-alanine + H2O = pyruvate + chloride + NH3;alpha-Amino acid <=> 2-Oxo acid + Ammonia" "D-serine => NH4(+) + pyruvate;NH4(+) + pyruvate => D-serine" "D-Serine = pyruvate + NH3;3-chloro-D-alanine + H2O = pyruvate + chloride + NH3;alpha-Amino acid <=> 2-Oxo acid + Ammonia" D-Serine <=> Pyruvate + Ammonia 4 out of 5 D-serine = pyruvate + NH(3). {ECO:0000269|PubMed:17869212, ECO:0000269|PubMed:17937657}. D-Serine <=> Pyruvate + Ammonia YES Glycine, serine and threonine metabolism pathway from kegg E630 Glycine, serine and threonine metabolism "Glycine, serine and threonine metabolism;path:map00260" +456 YGL226C-A "Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins" 2.4.99.18 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5 (Oligosaccharyl transferase subunit OST5) (EC 2.4.99.18) (Oligosaccharyl transferase 9.5 kDa subunit) (Oligosaccharyl transferase subunit zeta) "OST5; dolichyl-diphosphooligosaccharide--protein glycotransferase subunit" "oligosaccharyl transferase complex ζ subunit" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate 4 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +460 YGL257C "Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans" 2.4.1.- Mannosyltransferase Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans. 2.4.1.- Alpha-1,3-mannosyltransferase MNT2 (EC 2.4.1.-) "MNT2; alpha-1,3-mannosyltransferase MNT2" "α-1,3-mannosyltransferase MMN2" GDP-alpha-D-mannose + an alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] => an alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] + GDP + H+ "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" 3 out of 5 NA "GDP-D-mannose + G10842 <=> GDP + G10843;GDP-D-mannose + G10843 <=> GDP + G11055" YES Other types of O-glycan biosynthesis pathway from kegg "H815;H837;H838;H839" "PATHWAY: Protein modification; protein glycosylation." Other types of O-glycan biosynthesis protein O-mannosylation I (yeast) NA Golgi membrane "Golgi membrane;vacuole;Golgi;cell envelope" Golgi membrane +462 YGR012W "Putative cysteine synthase; localized to the mitochondrial outer membrane" 2.5.1.47 Putative cysteine synthase Putative cysteine synthase that catalyzes the conversion of O-acetyl-L-serine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway. However, this CS-like protein is unlikely to function in cysteine biosynthesis. It seems that in S.cerevisiae cysteine biosynthesis occurs exclusively through the cystathionine pathway and not via direct incorporation of sulfur into OAS. {ECO:0000305|PubMed:9409150}. 2.5.1.47 Putative cysteine synthase (CS) (EC 2.5.1.47) (Cysteine synthase-like protein) (CSl) (O-acetylserine (thiol)-lyase) (OAS-TL) (O-acetylserine sulfhydrylase) "MCY1; putative cysteine synthase" 2.5.1.47 cysteine synthase "O-acetyl-L-serine + hydrogen sulfide => L-cysteine + acetate;L-cysteine + acetate => O-acetyl-L-serine + hydrogen sulfide" "O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate;O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate;O-acetyl-L-serine + thiosulfate = S-sulfo-L-cysteine + acetate;O-acetyl-Ser + selenide = selenocysteine + acetate;O-Acetyl-L-serine + Thiosulfate + Thioredoxin + H+ <=> L-Cysteine + Sulfite + Thioredoxin disulfide + Acetate;L-cysteine + dithiothreitol = S-(2,3-hydroxy-4-thiobutyl)-L-cysteine + H2S" "O-acetyl-L-serine + hydrogen sulfide => L-cysteine + acetate;L-cysteine + acetate => O-acetyl-L-serine + hydrogen sulfide" "O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate;O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate;O-acetyl-L-serine + thiosulfate = S-sulfo-L-cysteine + acetate;O-acetyl-Ser + selenide = selenocysteine + acetate;O-Acetyl-L-serine + Thiosulfate + Thioredoxin + H+ <=> L-Cysteine + Sulfite + Thioredoxin disulfide + Acetate;L-cysteine + dithiothreitol = S-(2,3-hydroxy-4-thiobutyl)-L-cysteine + H2S" "O-acetyl-L-serine + hydrogen selenide = L-selenocysteine + acetate + H+;O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate + H+;O-acetyl-L-serine + thiosulfate = S-sulfo-L-cysteine + acetate + H+" "O-Acetyl-L-serine + Hydrogen sulfide <=> L-Cysteine + Acetate;O-Acetyl-L-serine + Hydrogen selenide <=> L-Selenocysteine + Acetate;O-Acetyl-L-serine + Thiosulfate + Thioredoxin + H+ <=> L-Cysteine + Sulfite + Thioredoxin disulfide + Acetate" 3 out of 5 O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. {ECO:0000250|UniProtKB:P0ABK5}. O-acetyl-L-serine + hydrogen sulfide <=> L-cysteine + acetate YES Cysteine and methionine metabolism pathway from kegg E364 "Cysteine and methionine metabolism;Sulfur metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids" "Cysteine and methionine metabolism;path:map00270;Sulfur metabolism;path:map00920;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Biosynthesis of antibiotics;path:map01130" "mitochondrion;mitochondrial membrane" "mitochondrion;mitochondrial membrane" "mitochondrion;mitochondrial membrane" +466 YGR036C "Dolichyl pyrophosphate (Dol-P-P) phosphatase; has a luminally oriented active site in the ER; cleaves the anhydride linkage in Dol-P-P; required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation" 3.6.1.43 Dolichyl pyrophosphate (Dol-P-P) phosphatase Non-essential protein which is required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. {ECO:0000269|PubMed:10024662, ECO:0000269|PubMed:11504728}. 3.6.1.43 Dolichyldiphosphatase (EC 3.6.1.43) (Dolichyl pyrophosphate phosphatase) "CAX4, CWH8; Cax4p" 3.6.1.43 CAX4 DOLPP1 dephosphorylates DOLDP to DOLP "dolichyl diphosphate + H2O => dolichyl phosphate + H(+) + phosphate;dolichyl phosphate + H(+) + phosphate => dolichyl diphosphate + H2O" dolichyl diphosphate + H2O = dolichyl phosphate + phosphate "dolichyl diphosphate + H2O => dolichyl phosphate + H(+) + phosphate;dolichyl phosphate + H(+) + phosphate => dolichyl diphosphate + H2O" dolichyl diphosphate + H2O = dolichyl phosphate + phosphate a dolichyl diphosphate + H2O = a dolichyl phosphate + phosphate + H+ Dolichyl diphosphate + H2O <=> Dolichyl phosphate + Orthophosphate 4 out of 5 Dolichyl diphosphate + H(2)O = dolichyl phosphate + phosphate. Dolichyl diphosphate + H2O <=> Dolichyl phosphate + Orthophosphate YES N-Glycan biosynthesis pathway from kegg "H193;H1135" "PATHWAY: Protein modification; protein glycosylation." N-Glycan biosynthesis Synthesis of Dolichyl-phosphate "N-Glycan biosynthesis;path:map00510" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +468 YGR043C "Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication" 2.2.1.2 Transaldolase of unknown function Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. 2.2.1.2 Transaldolase NQM1 (EC 2.2.1.2) (Non-quiescent mutant protein 1) "NQM1; sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1" 2.2.1.2 transaldolase "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate;sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate" "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => beta-D-fructose 6-phosphate + D-erythrose 4-phosphate;beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate" "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate;dihydroxyacetone + D-glyceraldehyde 3-phosphate = D-fructose 6-phosphate" "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => beta-D-fructose 6-phosphate + D-erythrose 4-phosphate;beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate" "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate;dihydroxyacetone + D-glyceraldehyde 3-phosphate = D-fructose 6-phosphate" D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> beta-D-fructofuranose 6-phosphate + D-erythrose 4-phosphate Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + beta-D-Fructose 6-phosphate "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate;sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate" 4 out of 5 Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. {ECO:0000255|PROSITE-ProRule:PRU10019, ECO:0000269|PubMed:18831051}. Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + beta-D-Fructose 6-phosphate YES Pentose phosphate pathway pathway from kegg "E70;H745" "PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3." "Pentose phosphate pathway;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids" pentose phosphate pathway // pentose phosphate pathway (non-oxidative branch) "Insulin effects increased synthesis of Xylulose-5-Phosphate;Pentose phosphate pathway (hexose monophosphate shunt)" "Pentose phosphate pathway;path:map00030;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" "nucleus;cytoplasm" +469 YGR046W "Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition" 2.7.7.41 Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase) Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. {ECO:0000269|PubMed:16790493, ECO:0000269|PubMed:16943180, ECO:0000269|PubMed:19114592, ECO:0000269|PubMed:23623749}. 2.7.7.41 Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (Mitochondrial import protein MMP37) (Mitochondrial matrix protein of 37 kDa) (Mitochondrial translocator assembly and maintenance protein 41) "TAM41, MMP37; putative phosphatidate cytidylyltransferase" Translocator Assembly and Maintenance 41 "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate;a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)" "CTP + phosphatidate = diphosphate + CDP-diacylglycerol;dCTP + phosphatidate = diphosphate + dCDPdiacylglycerol;CTP + 2,3,4-saturated L-phosphatidate + H+ = diphosphate + CDP-2,3,4-saturated-diacylglycerol" "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate;a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)" "CTP + phosphatidate = diphosphate + CDP-diacylglycerol;dCTP + phosphatidate = diphosphate + dCDPdiacylglycerol;CTP + 2,3,4-saturated L-phosphatidate + H+ = diphosphate + CDP-2,3,4-saturated-diacylglycerol" 5 out of 5 CTP + phosphatidate = diphosphate + CDP-diacylglycerol. {ECO:0000269|PubMed:23623749}. CTP + phosphatidate = diphosphate + CDP-diacylglycerol YES Glycerophospholipid metabolism "pathway from kegg; reaction from uniprot" "E679;H137;H788" "PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. {ECO:0000269|PubMed:19114592, ECO:0000269|PubMed:20485265}." "Glycerophospholipid metabolism;path:map00564;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Phosphatidylinositol signaling system;path:map04070" mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +471 YGR062C "Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p" NA Protein required for membrane insertion of C-terminus of Cox2p Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space. {ECO:0000269|PubMed:11950926}. NA Mitochondrial inner membrane protein COX18 (Cytochrome c oxidase assembly protein 18) "COX18, OXA2; membrane insertase COX18" NA Cytochrome c OXidase NA NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 4 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA NA aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +478 YGR144W "Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents" Thiazole synthase Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance. {ECO:0000255|HAMAP-Rule:MF_03158, ECO:0000269|PubMed:15544818, ECO:0000269|PubMed:16171982, ECO:0000269|PubMed:16734458, ECO:0000269|PubMed:17309261, ECO:0000269|PubMed:18652458, ECO:0000269|PubMed:22031445, ECO:0000269|PubMed:9367751}. Thiamine thiazole synthase (Thiazole biosynthetic enzyme) "THI4, ESP35, MOL1; thiamine thiazole synthase" NAD+ + Glycine + Sulfur donor <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + Nicotinamide + 3 H2O 5 out of 5 NA NAD+ + Glycine + Sulfur donor <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + Nicotinamide + 3 H2O YES Thiamine metabolism pathway from kegg thiamine biosynthesis "Thiamine metabolism;Metabolic pathways" NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +480 YGR154C "Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization" "1.8.5.1;2.5.1.18" Omega-class glutathione transferase Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). {ECO:0000269|PubMed:16709151}. "2.5.1.18; 1.8.5.1" Glutathione S-transferase omega-like 1 (EC 2.5.1.18) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) "GTO1; omega-class glutathione transferase" NA Glutathione Transferase Omega-like NA "L-dehydroascorbate + 2 glutathione => L-ascorbate + glutathione disulfide;L-ascorbate + glutathione disulfide => L-dehydroascorbate + 2 glutathione;glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate;5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione;L-dehydroascorbate + 2 glutathione => L-ascorbate + glutathione disulfide;L-ascorbate + glutathione disulfide => L-dehydroascorbate + 2 glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin;2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate" "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+;glutathione + 4-hydroxy-2-nonenal = 4-hydroxy-2-nonenal-glutathione conjugate;glutathione + RX = a glutathione-toxin conjugate + HX" NA NA 4 out of 5 "RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:16709151}.; 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate. {ECO:0000269|PubMed:16709151}." "RX + glutathione = HX + R-S-glutathione;2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate" YES Glutathione metabolism "pathway from kegg; reaction from uniprot" "H675;H1101;NA" NA NA NA NA NA "Glutathione metabolism;path:map00480;Metabolism of xenobiotics by cytochrome P450;path:map00980;Drug metabolism - cytochrome P450;path:map00982;NA" peroxisome peroxisome peroxisome +485 YGR199W "Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases" 2.4.1.109 Protein O-mannosyltransferase Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. {ECO:0000250|UniProtKB:P33775, ECO:0000303|PubMed:18182384, ECO:0000303|PubMed:9184828}. 2.4.1.109 Dolichyl-phosphate-mannose--protein mannosyltransferase 6 (EC 2.4.1.109) "PMT6; dolichyl-phosphate-mannose-protein mannosyltransferase PMT6" 2.4.1.109 dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase "[protein]-L-serine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => [protein]-L-serine + dolichyl beta-D-mannosyl phosphate;[protein]-L-threonine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+) => [protein]-L-threonine + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + alpha-D-Man-1-Ser/Thr;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein];dolichyl beta-D-mannosyl phosphate + [protein]-(L-serine/L-threonine) = dolichyl phosphate + [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+;dolichyl phosphate D-mannose + protein AN5660 = dolichyl phosphate + O-D-mannosylprotein;dolichyl phosphate D-mannose + alpha-dystroglycan = dolichyl phosphate + O-D-mannosyl-[alpha-dystroglycan];dolichyl phosphate D-mannose + protein Aga2 = dolichyl phosphate + O-D-mannosylprotein Aga2;dolichyl phosphate D-mannose + protein Bar1 = dolichyl phosphate + O-D-mannosylprotein Bar1;dolichyl phosphate D-mannose + protein chitinase 1 = dolichyl phosphate + O-D-mannosylprotein chitinase 1;dolichyl phosphate D-mannose + protein Ggp1/Gas1 = dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1;dolichyl phosphate D-mannose + protein Kex2 = dolichyl phosphate + O-D-mannosylprotein Kex2;dolichyl phosphate D-mannose + protein Kre9 = dolichyl phosphate + O-D-mannosylprotein Kre9;dolichyl phosphate D-mannose + protein Pir2/hsp150 = dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150;dolichyl phosphate D-mannose + ribonuclease 2 = dolichyl phosphate + ribonuclease 2-D-mannose;dolichyl phosphate D-mannose + glucoamylase I = dolichyl phosphate + O-D-mannosyl glucoamylase I;dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein" "[protein]-L-serine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => [protein]-L-serine + dolichyl beta-D-mannosyl phosphate;[protein]-L-threonine + dolichyl beta-D-mannosyl phosphate => O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+);O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+) => [protein]-L-threonine + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + alpha-D-Man-1-Ser/Thr;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein];dolichyl beta-D-mannosyl phosphate + [protein]-(L-serine/L-threonine) = dolichyl phosphate + [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+;dolichyl phosphate D-mannose + protein AN5660 = dolichyl phosphate + O-D-mannosylprotein;dolichyl phosphate D-mannose + alpha-dystroglycan = dolichyl phosphate + O-D-mannosyl-[alpha-dystroglycan];dolichyl phosphate D-mannose + protein Aga2 = dolichyl phosphate + O-D-mannosylprotein Aga2;dolichyl phosphate D-mannose + protein Bar1 = dolichyl phosphate + O-D-mannosylprotein Bar1;dolichyl phosphate D-mannose + protein chitinase 1 = dolichyl phosphate + O-D-mannosylprotein chitinase 1;dolichyl phosphate D-mannose + protein Ggp1/Gas1 = dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1;dolichyl phosphate D-mannose + protein Kex2 = dolichyl phosphate + O-D-mannosylprotein Kex2;dolichyl phosphate D-mannose + protein Kre9 = dolichyl phosphate + O-D-mannosylprotein Kre9;dolichyl phosphate D-mannose + protein Pir2/hsp150 = dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150;dolichyl phosphate D-mannose + ribonuclease 2 = dolichyl phosphate + ribonuclease 2-D-mannose;dolichyl phosphate D-mannose + glucoamylase I = dolichyl phosphate + O-D-mannosyl glucoamylase I;dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein" a dolichyl beta-D-mannosyl phosphate + a [protein]-(L-serine/L-threonine) => a dolichyl phosphate + a [protein]-O-D-mannosyl-(L-serine/L-threonine) + H+ "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + G13027;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein]" 4 out of 5 Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein. {ECO:0000250|UniProtKB:P33775, ECO:0000303|PubMed:18182384, ECO:0000303|PubMed:9184828}. "Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-serinyl-[protein];Dolichyl phosphate D-mannose + [Protein]-L-serine <=> Dolichyl phosphate + G13027;Dolichyl phosphate D-mannose + [Protein]-L-threonine <=> Dolichyl phosphate + 3-O-(alpha-D-Mannosyl)-L-threonyl-[protein]" YES Mannose type O-glycan biosynthesis "pathway from kegg; ; reaction from kegg" H1179 "PATHWAY: Protein modification; protein glycosylation. {ECO:0000305}." "Other types of O-glycan biosynthesis;Mannose type O-glycan biosynthesis;Metabolic pathways" protein O-mannosylation I (yeast) "Other types of O-glycan biosynthesis;path:map00514;Mannose type O-glycan biosynthesis;path:map00515;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +487 YGR216C "Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs" 2.4.1.198 Membrane protein involved in the synthesis of GlcNAc-PI Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. {ECO:0000269|PubMed:8910381}. 2.4.1.198 Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1 (GPI-GlcNAc transferase complex subunit GPI1) (GPI-GnT subunit GPI1) (EC 2.4.1.198) "GPI1; phosphatidylinositol N-acetylglucosaminyltransferase" GlycosylPhosphatidylInositol anchoring biosynthesis "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" an L-1-phosphatidyl-inositol + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H+ UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 3 out of 5 UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol. UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H479;H1129" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000305|PubMed:8910381}." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;path:map00563;Metabolic pathways;path:map01100" endoplasmic reticulum +488 YGR227W "Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase; located in the ER; functions in pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation; has a role in regulation of ITR1 and INO1; human homolog ALG10B can complement yeast die2 null mutant" 2.4.1.256 Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. {ECO:0000269|PubMed:9597543}. 2.4.1.256 Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10) (Asparagine-linked glycosylation protein 10) (Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10) "DIE2, ALG10; dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2-glucosyltransferase" 2.4.1.256 "dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol α-1,2-glucosyltransferase" Addition of a third glucose to the N-glycan skeleton by Alg10 "alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+ Dolichyl D-glucosyl phosphate + G10599 <=> Dolichyl phosphate + G00008 4 out of 5 Dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:9597543}. Dolichyl D-glucosyl phosphate + G10599 <=> Dolichyl phosphate + G00008 YES N-Glycan biosynthesis pathway from kegg lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" endoplasmic reticulum membrane +489 YGR234W "Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" 1.14.12.17 Nitric oxide oxidoreductase " Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.; FUNCTION: In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity." 1.14.12.17 Flavohemoprotein (EC 1.14.12.17) (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) "YHB1, YHB4; flavohemoglobin" 1.14.12.17 Yeast HemogloBin-like protein "NADPH + 2 nitric oxide + 2 O2 => H(+) + NADP(+) + 2 nitrate;H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2;NADH + 2 nitric oxide + 2 O2 => H(+) + NAD(+) + 2 nitrate;H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2" "2 nitric oxide + 2 O2 + NADPH = 2 nitrate + NADP+ + H+;2 nitric oxide + 2 O2 + NADH = 2 nitrate + NAD+ + H+;NADH + H+ + H2O2 = NAD+ + 2 H2O;NADH + Fe3+ = NAD+ + Fe2+;nitrite + NADH = NO + NAD+ + H2O;NO + O2 + e- = NO3-" "NADPH + 2 nitric oxide + 2 O2 => H(+) + NADP(+) + 2 nitrate;H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2;NADH + 2 nitric oxide + 2 O2 => H(+) + NAD(+) + 2 nitrate;H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2" "2 nitric oxide + 2 O2 + NADPH = 2 nitrate + NADP+ + H+;2 nitric oxide + 2 O2 + NADH = 2 nitrate + NAD+ + H+;NADH + H+ + H2O2 = NAD+ + 2 H2O;NADH + Fe3+ = NAD+ + Fe2+;nitrite + NADH = NO + NAD+ + H2O;NO + O2 + e- = NO3-" 2 nitric oxide + NAD(P)H + 2 oxygen => 2 nitrate + NAD(P)+ + H+ 5 out of 5 2 nitric oxide + 2 O(2) + NAD(P)H = 2 nitrate + NAD(P)(+) + H(+). {ECO:0000269|PubMed:10922365}. 2 nitric oxide + 2 O2 + NAD(P)H <=> 2 nitrate + NAD(P)+ + H+ YES Nitrogen Metabolism "[c] : nadph + (2) no + (2) o2 --> h + nadp + (2) no3; Nitrogen Metabolism: pathway from e.coli model" E519 NA cytoplasm "nucleus;cytoplasm;mitochondrion" cytoplasm +497 YHR001W-A "Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain" NA Subunit of the ubiqunol-cytochrome c oxidoreductase complex Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR10 is required for stable association of the iron-sulfur protein with the complex. NA Cytochrome b-c1 complex subunit 10 (Complex III subunit 10) (Complex III subunit XI) (Ubiquinol-cytochrome c reductase complex 8.5 kDa protein) "QCR10; ubiquinol--cytochrome-c reductase subunit 10" NA ubiquinol-cytochrome C oxidoreductase NA NA NA NA NA 2 an oxidized c-type cytochrome[out] + an ubiquinol[membrane] => 2 a reduced c-type cytochrome[out] + a ubiquinone[membrane] + 2 H+[out] NA NA 4 out of 5 NA 2 an oxidized c-type cytochrome[out] + an ubiquinol[membrane] => 2 a reduced c-type cytochrome[out] + a ubiquinone[membrane] + 2 H+[out] YES Oxidative phosphorylation pathway from kegg NA aerobic respiration, electron transport chain NA "Oxidative phosphorylation;Metabolic pathways" aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +499 YJL002C "Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins" 2.4.99.18 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (EC 2.4.99.18) (Oligosaccharyl transferase 64 kDa subunit) (Oligosaccharyl transferase subunit OST1) (Oligosaccharyl transferase subunit alpha) "OST1, NLT1; dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1" NA "oligosaccharyl transferase complex α subunit" NA "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA NA 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps NA "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +500 YJL003W "Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase" NA Mitochondrial inner membrane protein Required for the assembly of cytochrome c oxidase. {ECO:0000269|PubMed:12446688}. NA Cytochrome c oxidase assembly protein COX16, mitochondrial "COX16; Cox16p" NA Cytochrome c OXidase NA NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 3 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA NA aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +501 YJL011C "RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" RNA polymerase III subunit C17 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation. DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (RNA polymerase III subunit C17) "RPC17; DNA-directed RNA polymerase III subunit RPC17" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase NA nucleus "nucleus;cytoplasm" nucleus +506 YJL046W "Putative lipoate-protein ligase; required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss" "2.7.7.63;6.3.1.20" Putative lipoate-protein ligase Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. {ECO:0000250}. 6.3.1.20 Putative lipoate-protein ligase A (EC 6.3.1.20) (Altered inheritance rate of mitochondria protein 22) "AIM22, LIP3, RRG3; putative lipoate--protein ligase" 6.3.1.20 octanoyl-CoA-protein transferase LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs "(R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP => [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+);[lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+) => (R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP" "ATP + (R)-lipoate = lipoyl-AMP + diphosphate;ATP + (R)-Lipoate + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP + Diphosphate;Lipoyl-AMP + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP;[glycine cleavage system lipoyl-carrier protein]-L-lysine + ATP + (R)-lipoate = AMP + diphosphate + [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + H+;[lipoyl-carrier protein]-L-lysine + octanoate + ATP = [lipoyl-carrier protein] N6-octanoyl-L-lysine + AMP + diphosphate + H+;ATP + lipoate + apoprotein = AMP + diphosphate + protein N6-(lipoyl)lysine;lipoic acid + ATP + apoprotein = diphosphate + AMP + N6-(lipoyl)-lysine;lipoyl-AMP + [GLDH1 protein]-L-lysine = [GLDH1 protein]-N6-(lipoyl)lysine + AMP" "(R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP => [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+);[lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+) => (R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP" "ATP + (R)-lipoate = lipoyl-AMP + diphosphate;ATP + (R)-Lipoate + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP + Diphosphate;Lipoyl-AMP + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP;[glycine cleavage system lipoyl-carrier protein]-L-lysine + ATP + (R)-lipoate = AMP + diphosphate + [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + H+;[lipoyl-carrier protein]-L-lysine + octanoate + ATP = [lipoyl-carrier protein] N6-octanoyl-L-lysine + AMP + diphosphate + H+;ATP + lipoate + apoprotein = AMP + diphosphate + protein N6-(lipoyl)lysine;lipoic acid + ATP + apoprotein = diphosphate + AMP + N6-(lipoyl)-lysine;lipoyl-AMP + [GLDH1 protein]-L-lysine = [GLDH1 protein]-N6-(lipoyl)lysine + AMP" "octanoyl-CoA + [2-oxoglutarate dehydrogenase E2 lipoyl-carrier protein]-L-lysine => a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + coenzyme A + H+;octanoyl-CoA + [pyruvate dehydrogenase E2 lipoyl-carrier protein]-L-lysine => a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + coenzyme A + H+" "ATP + (R)-Lipoate <=> Diphosphate + Lipoyl-AMP;Lipoyl-AMP + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP;ATP + (R)-Lipoate + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP + Diphosphate" 4 out of 5 ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N(6)-(lipoyl)lysine + AMP + diphosphate. "ATP + (R)-Lipoate <=> Diphosphate + Lipoyl-AMP;Lipoyl-AMP + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP;ATP + (R)-Lipoate + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP + Diphosphate" YES Lipoic acid metabolism pathway from kegg "PATHWAY: Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.; PATHWAY: Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2." "Lipoic acid metabolism;Metabolic pathways" superpathway of lipoate biosynthesis and incorporation (PDH, KGDH, GCV) // lipoate biosynthesis and incorporation (pyruvate dehydrogenase and oxoglutarate dehydrogenase) Glyoxylate metabolism and glycine degradation "Lipoic acid metabolism;path:map00785;Metabolic pathways;path:map01100" mitochondrion +509 YJL062W "Integral plasma membrane protein; involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity" 2.-.-.- Integral plasma membrane protein Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. Although not essential, addition of ethanolamine phosphate to the second mannose plays an important role in cell separation via the GPI-based modification of daughter-specific proteins. {ECO:0000269|PubMed:10329735, ECO:0000269|PubMed:14985347, ECO:0000269|PubMed:15452134}. 2.-.-.- GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (Glycosylphosphatidylinositol-anchor biosynthesis protein 7) (Local anestheticum-sensitive protein 21) "LAS21, GPI7; mannose-ethanolamine phosphotransferase LAS21" Local Anestheticum Sensitive Phosphatidylethanolamine + G00141 <=> 1,2-Diacyl-sn-glycerol + G00151 5 out of 5 NA Phosphatidylethanolamine + G00141 <=> 1,2-Diacyl-sn-glycerol + G00151 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis." Glycosylphosphatidylinositol (GPI)-anchor biosynthesis NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" endoplasmic reticulum membrane +517 YJL126W "Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" 3.5.-.- Nit protein Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. {ECO:0000269|PubMed:28373563}. 3.5.1.- Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.-) (Nitrilase homolog 1) "NIT2; putative hydrolase" NA nitrilase NA NA NA NA NA "a nitrile + 2 H2O = a carboxylate + ammonium;indole-3-acetonitrile + 2 H2O => ammonium + indole-3-acetate" NA NA 4 out of 5 N-(4-oxoglutarate)-L-cysteinylglycine + H(2)O = 2-oxoglutarate + L-cysteinylglycine. {ECO:0000269|PubMed:28373563}. N-(4-oxoglutarate)-L-cysteinylglycine + H(2)O <=> 2-oxoglutarate + L-cysteinylglycine YES other NA "E263;H1023" NA NA NA indole-3-acetate biosynthesis V (bacteria and fungi) NA NA "cytoplasm;mitochondrion" "cytoplasm;mitochondrion" "mitochondrion;cytoplasm" +521 YJL140W "RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation" RNA polymerase II subunit B32 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex is necessary for promoter-directed transcription initiation but is not required for recruitment of Pol II to active preinitiation complexes and seems to be dispensable for transcription elongation and termination. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II. Involved in DNA repair of damage in the transcribed strand. RPB4 is dispensable under optimal growth conditions, but becomes essential during heat or cold shock and under nutrient depletion. Suppresses the RBP9-mediated transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER) but facilitates the RAD26-mediated TCR subpathway. Under stress conditions only, involved in mRNA export to the cytoplasm. Involved in mRNA decay. Promotes or enhances the deadenylation process of specific mRNAs and may recruit PAT1 and the LSM1-7 complex to these mRNAs, thus stimulating their decapping and further decay. {ECO:0000269|PubMed:11087726, ECO:0000269|PubMed:11382749, ECO:0000269|PubMed:12411509, ECO:0000269|PubMed:12857861, ECO:0000269|PubMed:15304220, ECO:0000269|PubMed:16357218, ECO:0000269|PubMed:1985924}. DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (B32) (DNA-directed RNA polymerase II 32 kDa polypeptide) "RPB4, CTF15; DNA-directed RNA polymerase II subunit RPB4" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA "nucleus;cytoplasm" "nucleus;cytoplasm" "nucleus;cytoplasm" +523 YJL148W "RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p" RNA polymerase I subunit A34.5 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. The heterodimer formed by RPA34 and RPA49 stimulates transcript elongation by Pol I. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:20797630, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184, ECO:0000269|PubMed:9121426}. DNA-directed RNA polymerase I subunit RPA34 (A34) (DNA-directed DNA-dependent RNA polymerase 34.5 kDa polypeptide) (A34.5) "RPA34, CST21; DNA-directed RNA polymerase I subunit RPA34" RNA Polymerase A a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus +526 YJL168C "Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia" 2.1.1.43 Histone methyltransferase with a role in transcriptional elongation Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent. {ECO:0000269|PubMed:11839797, ECO:0000269|PubMed:12629047, ECO:0000269|PubMed:12736296, ECO:0000269|PubMed:12773564, ECO:0000269|PubMed:12917322, ECO:0000269|PubMed:15798214, ECO:0000269|PubMed:16227595}. 2.1.1.43 Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.43) (Lysine N-methyltransferase 3) (SET domain-containing protein 2) "SET2, EZL1, KMT3; histone methyltransferase SET2" 2.1.1.43 SET domain-containing "EHMT1:EHMT2 methylates IL8 promoter;EHMT1:EHMT2 methylates IL8 promoter;EHMT1:EHMT2 methylates IL6 promoter;EHMT1:EHMT2 methylates IL6 promoter;eNoSC deacetylates histone H3;eNoSC dimethylates histone H3 at lysine-9;Formation of energy-dependent Nucleolar Silencing Complex (eNoSC);SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9);SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9);SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9);WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36);WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36);SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4);EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9);EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9);EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9);EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9);WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4);SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36);WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36);WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36);WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27);WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27);WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27);WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27);WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27);WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27);HERC2 and PIAS4 are recruited to DNA DSBs;ATM phosphorylates HERC2;PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs;HERC2 facilitates UBE2N:UBE2V2 binding to RNF8;RNF8 and RNF168 ubiquitinate H2AFX;WHSC1 dimethylates histone H4 on lysine K21 at DSBs;WHSC1 binds DNA DSBs;ATM phosphorylates WHSC1;ATM phosphorylates WHSC1;KDM4A,B bind H4K20Me2;RNF8 and RNF168 ubiquitinate KDM4A,B" "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" "S-adenosyl-L-methionine + [histone]-L-lysine => S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+);S-adenosyl-L-homocysteine + [histone]-N(6)-methyl-L-lysine + H(+) => S-adenosyl-L-methionine + [histone]-L-lysine" "S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine;[histone]-L-lysine + S-adenosyl-L-methionine = [histone] N6-methyl-L-lysine + H+ + S-adenosyl-L-homocysteine;S-adenosyl-L-methionine + dimethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + monomethylated histone H3(K9) = S-adenosyl-L-homocysteine + trimethylated histone H3(K9);S-adenosyl-L-methionine + [protein Cren7]-L-lysine = S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine" a [histone]-L-lysine + S-adenosyl-L-methionine => a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+ "Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine;S-Adenosyl-L-methionine + Histone-L-lysine <=> S-Adenosyl-L-homocysteine + Histone N6-methyl-L-lysine;S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine;S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine" 5 out of 5 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. {ECO:0000255|PROSITE-ProRule:PRU00901}. S-adenosyl-L-methionine + L-lysine-[histone] <=> S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone] YES Lysine metabolism "pathway from kegg; reaction from uniprot; Lysine degradation was changed into lysine metabolism based on yeast 7.7" "H372;H974" Lysine degradation "Senescence-Associated Secretory Phenotype (SASP);PKMTs methylate histone lysines;SIRT1 negatively regulates rRNA expression;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "Lysine degradation;path:map00310" nucleus "nucleus;cytoplasm" nucleus +528 YJL180C "Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency" Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase Essential for the assembly of the mitochondrial F1-F0 complex. {ECO:0000269|PubMed:1826907}. Protein ATP12, mitochondrial "ATP12; ATP synthase complex assembly protein ATP12" ATP synthase ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] 3 out of 5 NA ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] YES Oxidative phosphorylation pathway from kegg superpathway of purine nucleotides de novo biosynthesis I // adenosine nucleotides de novo biosynthesis // adenosine ribonucleotides de novo biosynthesis NA mitochondrion "mitochondrion;mitochondrial membrane" mitochondrion +531 YJL200C "Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol" "4.2.1.-;4.2.1.3" Putative mitochondrial aconitase isozyme Catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. {ECO:0000269|PubMed:23106124}. 4.2.1.- Homocitrate dehydratase, mitochondrial (EC 4.2.1.-) (Aconitase 2) "ACO2; aconitate hydratase ACO2" aconitate hydratase "isocitrate <=> citrate;ACO1 binds 4Fe-4S;ACO1:4Fe-4S isomerises CIT to ISCIT;SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2;SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2;citrate <=> isocitrate" "citrate => isocitrate;isocitrate => citrate" "Citrate = cis-aconitate + H2O;(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O;citrate = isocitrate;isocitrate = cis-aconitate" "cis-aconitate + H2O <=> D-threo-isocitrate;citrate <=> cis-aconitate + H2O;citrate <=> D-threo-isocitrate" (R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O "isocitrate <=> citrate;citrate <=> isocitrate" 4 out of 5 (R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H(2)O. "(R)-2-hydroxybutane-1,2,4-tricarboxylate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O; citrate <=> isocitrate" YES "Lysine metabolism; Citrate cycle (TCA cycle)" "pathway from kegg and uniprot; Lysine biosynthesis was changed into lysine metabolism based on yeast7.7" H867 TCA cycle, aerobic respiration "PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 2/5." "Lysine biosynthesis;Metabolic pathways;Biosynthesis of antibiotics;2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids" glyoxylate cycle // TCA cycle, aerobic respiration "Citric acid cycle (TCA cycle);Iron uptake and transport" NA mitochondrion mitochondrion mitochondrion +533 YJR006W "Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia" 2.7.7.7 Subunit of DNA polymerase delta (polymerase III) DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. {ECO:0000269|PubMed:7567461}. 2.7.7.7 DNA polymerase delta small subunit (EC 2.7.7.7) (Hydroxyurea-sensitive protein 2) "POL31, HUS2, HYS2, SDP5; DNA-directed DNA polymerase delta subunit POL31" POLymerase "Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA synthesis. Pathway from kegg H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination" "Removal of the Flap Intermediate;Processive synthesis on the lagging strand" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus "nucleus;cytoplasm" nucleus +538 YJR040W "Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism" Voltage-gated chloride channel Anion/proton exchange transporter involved in iron and copper cation homeostasis. Involved in intracellular iron metabolism during growth on fermentable and non fermentable carbon sources. Required for proper copper-loading and maturation of multicopper oxidase FET3. Important for adjusting intracellular compartment pH to more alkaline pH under iron limitation. May also transport chloride ions through the plasma membrane. {ECO:0000269|PubMed:12074596, ECO:0000269|PubMed:17662057, ECO:0000269|PubMed:7505388, ECO:0000269|PubMed:9520490, ECO:0000269|PubMed:9614122}. "Anion/proton exchange transporter GEF1 (CLC protein GEF1) (ClC-A) (ClC-Y1) (Voltage-gated chloride channel) [Cleaved into: GEF1 N-terminal; GEF1 C-terminal]" "GEF1, CLC; Gef1p" Glycerol Ethanol, Ferric requiring "CLCN4/5/6 exchange Cl- for H+;CLCN4/5/6 exchange Cl- for H+;CLCN4/5/6 exchange Cl- for H+;CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region;CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region" "CLCN4/5/6 exchange Cl- for H+;CLCN4/5/6 exchange Cl- for H+;CLCN4/5/6 exchange Cl- for H+;CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region;CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region" 5 out of 5 NA Cl- <=> Cl- YES chloride transport Voltage-gated chloride channel Stimuli-sensing channels NA "Golgi membrane;cytoplasm" "Golgi membrane;vacuole;cytoplasm;endoplasmic reticulum;Golgi;cell envelope" "Golgi membrane;cytoplasm" +539 YJR043C "Third subunit of DNA polymerase delta; involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; forms a complex with Rev3p, Rev7p and Pol31p; interacts with Hys2p, PCNA (Pol30p), and Pol1p" Third subunit of DNA polymerase delta DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. DNA polymerase delta subunit 3 "POL32, REV5; DNA polymerase delta subunit POL32" POLymerase "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 NA 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination" NA nucleus nucleus nucleus +540 YJR051W "Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication" 1.3.1.6 Fumarate reductase, catalyzes the reduction of fumarate to succinate Irreversibly catalyzes the reduction of fumarate to succinate. Together with the second isozyme of soluble fumarate reductase (FRD1), essential for anaerobic growth. Involved in maintaining redox balance during oxygen deficiency conditions. Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2). {ECO:0000269|PubMed:12949191, ECO:0000269|PubMed:17345583, ECO:0000269|PubMed:9587404, ECO:0000269|PubMed:9711846}. 1.3.1.6 Fumarate reductase 2 (FRDS2) (EC 1.3.1.6) (NADH-dependent fumarate reductase) (Osmotic sensitivity protein 1) (Soluble fumarate reductase, mitochondrial isozyme) "OSM1; fumarate reductase" fumarate reductase (NADH) "NAD(+) + succinate => fumarate + H(+) + NADH;fumarate + H(+) + NADH => NAD(+) + succinate" succinate + NAD+ = fumarate + NADH + H+ "NAD(+) + succinate => fumarate + H(+) + NADH;fumarate + H(+) + NADH => NAD(+) + succinate" succinate + NAD+ = fumarate + NADH + H+ succinate + NAD+ = fumarate + NADH + H+ 5 out of 5 Succinate + NAD(+) = fumarate + NADH. {ECO:0000269|PubMed:9587404}. succinate + NAD+ <=> fumarate + NADH + H+ YES Carbon fixation pathways in prokaryotes required for the reoxidation of intracellular NADH under anaerobic conditions "Carbon fixation pathways in prokaryotes;path:map00720;Microbial metabolism in diverse environments;path:map01120" mitochondrion "mitochondrion;endoplasmic reticulum" mitochondrion +543 YJR063W "RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism" RNA polymerase I subunit A12.2 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. Proposed to contribute to the polymerase catalytic activity and form the polymerase active center together with the two largest subunits. Subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. Involved in transcriptional termination. {ECO:0000269|PubMed:15073335, ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerase I subunit RPA12 (A12) (A12.2) (DNA-directed RNA polymerase I 13.7 kDa polypeptide) "RPA12, RRN4; DNA-directed RNA polymerase I core subunit RPA12" RNA Polymerase A Binding of RRN3 to RNA Polymerase I a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation NA nucleus nucleus nucleus +545 YJR069C "Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA" "3.6.1.19;3.6.1.9" Nucleoside triphosphate pyrophosphohydrolase Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528, ECO:0000269|PubMed:17899088, ECO:0000269|PubMed:9918490}. 3.6.1.9 Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Hydroxylaminopurine sensitivity protein 1) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) "HAM1; nucleoside triphosphate pyrophosphohydrolase HAM1" 6-n-HydroxylAMinopurine sensitive "ITPA hydrolyses ITP to IMP;ITPA hydrolyses XTP to XMP;ITPA hydrolyses dITP to dIMP" "NA;dUTP + H2O => diphosphate + dUMP + H(+);diphosphate + dUMP + H(+) => dUTP + H2O;a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+);a ribonucleoside 5'-phosphate + diphosphate + H(+) => a ribonucleoside 5'-triphosphate + H2O;dATP + H2O => dAMP + diphosphate + H(+);dAMP + diphosphate + H(+) => dATP + H2O;dGTP + H2O => dGMP + diphosphate + H(+);dGMP + diphosphate + H(+) => dGTP + H2O;dTTP + H2O => diphosphate + dTMP + H(+);diphosphate + dTMP + H(+) => dTTP + H2O;a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+);a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O" "dITP + H2O = dIMP + diphosphate;XTP + H2O = XMP + diphosphate;ITP + H2O = IMP + diphosphate;dCTP + H2O = dCMP + diphosphate;FAD + H2O = AMP + FMN;NAD+ + H2O = AMP + NMN;dUTP + H2O = dUMP + diphosphate;ATP + H2O = AMP + diphosphate;a nucleoside triphosphate + H2O = a nucleotide + diphosphate;CTP + H2O = CMP + diphosphate;UTP + H2O = UMP + diphosphate;GDP-mannose + H2O = GMP + D-mannose 1-phosphate;ADP-glucose + H2O = AMP + alpha-D-glucose 1-phosphate;NADH + H2O = NMNH + AMP;ITP + H2O = IMP + diphosphate;GTP + H2O = GMP + diphosphate;dGTP + H2O = dGMP + diphosphate;TTP + H2O = TMP + diphosphate;UDP + H2O = UMP + phosphate;dCTP + H2O = dCDP + phosphate;ATP + 2 H2O = AMP + 2 phosphate;dATP + H2O = dAMP + diphosphate;bis(p-nitrophenyl)phosphate + H2O = p-nitrophenol + p-nitrophenylphosphate;ADP-ribose + H2O = AMP + alpha-D-ribose 1-phosphate;dGTP + H2O = dGDP + phosphate;dCDP + H2O = dCMP + phosphate;dGDP + H2O = dGMP + phosphate;adenosine 5'-diphosphate + H2O = AMP + phosphate;CDP + H2O = CMP + phosphate;UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate;nicotinic acid adenine dinucleotide + H2O = nicotinic acid mononucleotide + 5'-AMP;CDP-glucose + H2O = CMP + D-glucose-1-phosphate;Dephospho-CoA + H2O <=> Pantetheine 4'-phosphate + AMP;UDP-N-acetyl-alpha-D-glucosamine + H2O = UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate;UDP-alpha-D-galactose + H2O = UMP + alpha-D-galactose-1-phosphate;UDP-glucuronic acid + H2O = UMP + glucuronic acid phosphate;UDP-N-acetyl-alpha-D-galactosamine + H2O = N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP;NADPH + H2O = NMNH + adenosine 2',5'-phosphate;NADP+ + H2O = NMN + adenosine 2',5'-phosphate;diadenosine 5',5''-P1, P5-pentaposphate + H2O = ATP + ADP + AMP + adenosine 5'-tetraphosphate;3 diadenosine 5',5''-P1, P4-tetraphosphate + 3 H2O = 2 ATP + 2 ADP + 2 AMP;TDP-glucose + H2O = TMP + D-glucose-1-phosphate;2-nitrophenyl phosphate + H2O = 2-nitrophenol + phosphate;ADP-ribose + H2O = AMP + phosphoribose;alpha-NADH + H2O = alpha-NMNH + AMP;4-nitrophenyl-5'-TMP + H2O = 4-nitrophenol + 5'-TMP;diadenosine 5',5''-P1, P2-diphosphate + H2O = AMP + AMP;2',3'-cAMP + H2O = adenosine monophosphate" "dUTP + H2O => diphosphate + dUMP + H(+);diphosphate + dUMP + H(+) => dUTP + H2O;a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+);a ribonucleoside 5'-phosphate + diphosphate + H(+) => a ribonucleoside 5'-triphosphate + H2O;dATP + H2O => dAMP + diphosphate + H(+);dAMP + diphosphate + H(+) => dATP + H2O;dGTP + H2O => dGMP + diphosphate + H(+);dGMP + diphosphate + H(+) => dGTP + H2O;dTTP + H2O => diphosphate + dTMP + H(+);diphosphate + dTMP + H(+) => dTTP + H2O;a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+);a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O" "dCTP + H2O = dCMP + diphosphate;FAD + H2O = AMP + FMN;NAD+ + H2O = AMP + NMN;dUTP + H2O = dUMP + diphosphate;ATP + H2O = AMP + diphosphate;a nucleoside triphosphate + H2O = a nucleotide + diphosphate;CTP + H2O = CMP + diphosphate;UTP + H2O = UMP + diphosphate;GDP-mannose + H2O = GMP + D-mannose 1-phosphate;ADP-glucose + H2O = AMP + alpha-D-glucose 1-phosphate;NADH + H2O = NMNH + AMP;ITP + H2O = IMP + diphosphate;GTP + H2O = GMP + diphosphate;dGTP + H2O = dGMP + diphosphate;TTP + H2O = TMP + diphosphate;UDP + H2O = UMP + phosphate;dCTP + H2O = dCDP + phosphate;ATP + 2 H2O = AMP + 2 phosphate;dATP + H2O = dAMP + diphosphate;bis(p-nitrophenyl)phosphate + H2O = p-nitrophenol + p-nitrophenylphosphate;ADP-ribose + H2O = AMP + alpha-D-ribose 1-phosphate;dGTP + H2O = dGDP + phosphate;dCDP + H2O = dCMP + phosphate;dGDP + H2O = dGMP + phosphate;adenosine 5'-diphosphate + H2O = AMP + phosphate;CDP + H2O = CMP + phosphate;UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate;nicotinic acid adenine dinucleotide + H2O = nicotinic acid mononucleotide + 5'-AMP;CDP-glucose + H2O = CMP + D-glucose-1-phosphate;Dephospho-CoA + H2O <=> Pantetheine 4'-phosphate + AMP;UDP-N-acetyl-alpha-D-glucosamine + H2O = UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate;UDP-alpha-D-galactose + H2O = UMP + alpha-D-galactose-1-phosphate;UDP-glucuronic acid + H2O = UMP + glucuronic acid phosphate;UDP-N-acetyl-alpha-D-galactosamine + H2O = N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP;NADPH + H2O = NMNH + adenosine 2',5'-phosphate;NADP+ + H2O = NMN + adenosine 2',5'-phosphate;diadenosine 5',5''-P1, P5-pentaposphate + H2O = ATP + ADP + AMP + adenosine 5'-tetraphosphate;3 diadenosine 5',5''-P1, P4-tetraphosphate + 3 H2O = 2 ATP + 2 ADP + 2 AMP;TDP-glucose + H2O = TMP + D-glucose-1-phosphate;2-nitrophenyl phosphate + H2O = 2-nitrophenol + phosphate;ADP-ribose + H2O = AMP + phosphoribose;alpha-NADH + H2O = alpha-NMNH + AMP;4-nitrophenyl-5'-TMP + H2O = 4-nitrophenol + 5'-TMP;diadenosine 5',5''-P1, P2-diphosphate + H2O = AMP + AMP;2',3'-cAMP + H2O = adenosine monophosphate" "GTP + H2O <=> GMP + Diphosphate;ITP + H2O <=> IMP + Diphosphate;dGTP + H2O <=> dGMP + Diphosphate;dUTP + H2O <=> dUMP + Diphosphate;XTP + H2O <=> Xanthosine 5'-phosphate + Diphosphate;dITP + H2O <=> 2'-Deoxyinosine 5'-phosphate + Diphosphate;6-Mercaptopurine ribonucleoside triphosphate + H2O <=> 6-Thioinosine-5'-monophosphate + Diphosphate" 5 out of 5 A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528}. "dUTP + H2O => diphosphate + dUMP + H(+);a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+);dATP + H2O => dAMP + diphosphate + H(+);dGTP + H2O => dGMP + diphosphate + H(+);dTTP + H2O => diphosphate + dTMP + H(+);a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)" YES Purine metabolism "pathway from kegg; A nucleoside triphosphate + H2O = a nucleotide + diphospha from uniprot" "E77;E649;H222" "Purine metabolism;Metabolic pathways" Purine catabolism "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Starch and sucrose metabolism;path:map00500;Riboflavin metabolism;path:map00740;Nicotinate and nicotinamide metabolism;path:map00760;Pantothenate and CoA biosynthesis;path:map00770;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +548 YJR104C "Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex" 1.15.1.1 Cytosolic copper-zinc superoxide dismutase Destroys radicals which are normally produced within the cells and which are toxic to biological systems. 1.15.1.1 Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) "SOD1, CRS4; superoxide dismutase SOD1" 1.15.1.1 cytoplasmic superoxide dismutase "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular);SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular);SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol);CCS transfers Cu to SOD1;CCS transfers Cu to SOD1;CCS transfers Cu to SOD1;SOD1:Zn2+ binds CCS:Zn2+:2xCu1+;SOD1:Zn2+ binds CCS:Zn2+:2xCu1+;SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space);Release of platelet cytosolic components;Release of platelet cytosolic components;Secretion of SOD3;Secretion of SOD3;Secretion of SOD3;2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates;2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates" "2 H(+) + 2 superoxide => H2O2 + O2;H2O2 + O2 => 2 H(+) + 2 superoxide" 2 superoxide + 2 H+ = O2 + H2O2 "2 H(+) + 2 superoxide => H2O2 + O2;H2O2 + O2 => 2 H(+) + 2 superoxide" 2 superoxide + 2 H+ = O2 + H2O2 2 superoxide + 2 H+ => hydrogen peroxide + oxygen 5 out of 5 2 superoxide + 2 H(+) = O(2) + H(2)O(2). 2 superoxide + 2 H+ => hydrogen peroxide + oxygen YES Peroxisome pathway from kegg "E398;H537" removal of superoxide radicals "Peroxisome;Longevity regulating pathway - multiple species" superoxide radicals degradation // ethylene biosynthesis "Platelet degranulation ;Detoxification of Reactive Oxygen Species" NA "cytoplasm;mitochondrial membrane" "nucleus;cytoplasm;mitochondrion;mitochondrial membrane" "mitochondrial membrane;cytoplasm" +549 YJR117W "Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves both isoprenylated and non-prenylated oligopeptides; contains multiple transmembrane spans; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and can complement yeast null mutant" 3.4.24.84 Highly conserved zinc metalloprotease Proteolytically removes the C-terminal three residues of farnesylated A-factor mating pheromone. Also acts to cleave the N-terminal extension of the pheromone. Does not act on Ras. {ECO:0000269|PubMed:10692417, ECO:0000269|PubMed:9015299, ECO:0000269|PubMed:9065405, ECO:0000269|PubMed:9700155, ECO:0000269|PubMed:9725832}. 3.4.24.84 CAAX prenyl protease 1 (EC 3.4.24.84) (A-factor-converting enzyme) (Prenyl protein-specific endoprotease 1) (PPSEP 1) "STE24, AFC1, PIO2; zinc metalloprotease" 3.4.24.84 CAAX prenyl protease 1 NA NA "S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide;farnesylated protein that ends with a CAAX sequence + H2O = [protein] C-terminal S-farnesyl-L-cysteine + peptide + H+;a-factor-CaaX + H2O = a-factor + aaX;a-factor-CaaX + H2O = a-factor-C + aaX;a-factor + H2O = fragments of a-factor" NA "S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide;farnesylated protein that ends with a CAAX sequence + H2O = [protein] C-terminal S-farnesyl-L-cysteine + peptide + H+;a-factor-CaaX + H2O = a-factor + aaX;a-factor-CaaX + H2O = a-factor-C + aaX;a-factor + H2O = fragments of a-factor" a farnesylated protein that ends with a CAAX sequence + H2O => a [protein] C-terminal S-farnesyl-L-cysteine + a peptide + H+ S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide NA 5 out of 5 The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids. S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide YES Terpenoid backbone biosynthesis pathway from kegg NA NA NA "Terpenoid backbone biosynthesis;Biosynthesis of antibiotics" NA NA "Terpenoid backbone biosynthesis;path:map00900;Biosynthesis of antibiotics;path:map01130" endoplasmic reticulum membrane "nucleus;mitochondrial membrane;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +550 YJR131W "Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation" 3.2.1.113 Alpha-1,2-mannosidase Involved in glycoprotein quality control as it is important for the targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations it further trims the carbohydrates to Man(5)GlcNAc(2). {ECO:0000269|PubMed:12090241}. 3.2.1.113 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Man(9)-alpha-mannosidase) "MNS1; mannosyl-oligosaccharide 1,2-alpha-mannosidase" 3.2.1.113 "mannosyl-oligosaccharide 1,2-α-mannosidase" "MAN1B1 hydrolyses 1,2-linked mannose (a branch);MAN1B1 hydrolyses a second 1,2-linked mannose (a branch);MAN1B1 hydrolyses 1,2-linked mannose (c branch);MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch);Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2;Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2" "2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn + 4 H2O <=> alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn + 4 D-Mannose;H2O + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O = (Man)5GlcNAc + 4 D-mannose;Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O = Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 D-mannose;Manalpha(1-2)Manalpha(1-3)Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 2 H2O = (Man)5GlcNAc + 2 D-mannose;alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + H2O = alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose;Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O = Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + D-mannose" "2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose;alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn + 4 H2O <=> alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn + 4 D-Mannose;H2O + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> D-Mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O = (Man)5GlcNAc + 4 D-mannose;Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O = Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 D-mannose;Manalpha(1-2)Manalpha(1-3)Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 2 H2O = (Man)5GlcNAc + 2 D-mannose;alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + H2O = alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose;Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O = Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + D-mannose" a [protein]-L-asparagine-[(mannosyl)9(N-acetylglucosaminyl)2] + H2O => a [protein]-L-asparagine-[(mannosyl)8(N-acetylglucosaminyl)2] + beta-D-mannopyranose "G00011 + 4 H2O <=> G00012 + 4 D-Mannose;H2O + G00011 <=> D-Mannose + G10694" 5 out of 5 Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). {ECO:0000269|PubMed:12090241}. "G00011 + 4 H2O <=> G00012 + 4 D-Mannose;H2O + G00011 <=> D-Mannose + G10694" YES N-Glycan biosynthesis pathway from kegg H405 "PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:12090241}." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (yeast) processing in the ER "ER Quality Control Compartment (ERQC);Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2" "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +551 YJR149W "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" 1.13.12.16 Putative protein of unknown function Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites. {ECO:0000250}. 1.13.12.16 Putative nitronate monooxygenase (EC 1.13.12.16) (Nitroalkane oxidase) putative nitronate monooxygenase 1.13.12.16 Unknown NA NA "ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O;ethylnitronate + oxygen = acetaldehyde + nitrite + [unspecified degradation products];3-aci-nitropropanoate + oxygen = 3-oxopropanoate + nitrite + [unspecified degradation products];ethylnitronate + O2 = acetaldehyde + nitrite + other products" NA "ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O;ethylnitronate + oxygen = acetaldehyde + nitrite + [unspecified degradation products];3-aci-nitropropanoate + oxygen = 3-oxopropanoate + nitrite + [unspecified degradation products];ethylnitronate + O2 = acetaldehyde + nitrite + other products" NA Ethylnitronate + Oxygen + Reduced FMN <=> Acetaldehyde + Nitrite + FMN + H2O NA 3 out of 5 Ethylnitronate + O(2) = acetaldehyde + nitrite + other products. Ethylnitronate + Oxygen + Reduced FMN <=> Acetaldehyde + Nitrite + FMN + H2O YES Nitrogen metabolism pathway from kegg NA NA NA Nitrogen metabolism NA NA "Nitrogen metabolism;path:map00910" cytoplasm cytoplasm cytoplasm +552 YJR155W "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" Putative aryl-alcohol dehydrogenase 1.1.1.- Putative aryl-alcohol dehydrogenase AAD10 (EC 1.1.1.-) "AAD10; putative aryl-alcohol dehydrogenase" aryl-alcohol dehydrogenase "3-chlorobenzyl alcohol + NAD+ = 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ = 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ = 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ = p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ = 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ = an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ = benzaldehyde + NADH + H+" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism "pathway from E.coli model; reaction from biocyc" "E646;E743;H1286" NA +553 YJR156C "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" Protein involved in synthesis of the thiamine precursor HMP Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. {ECO:0000250|UniProtKB:P43534}. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI11 (HMP-P synthase) (Hydroxymethylpyrimidine phosphate synthase) (Thiamine biosynthesis protein 11) (Thiamine pyrimidine synthase) "THI11; 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" MONOMER3O-9135 [an HMP-P synthase]-L-histidine + pyridoxal 5'-phosphate => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + an HMP-P synthase Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine 3 out of 5 NA Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine YES Thiamine metabolism pathway from kegg thiamine biosynthesis "PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000305|PubMed:12777485}." "Thiamine metabolism;Metabolic pathways" superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis NA +554 YLL001W "Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur; participates in endocytosis and regulates peroxisome fission along with Vps1p; mutants in the human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy" 3.6.5.5 Dynamin-related GTPase involved in mitochondrial organization Microtubule-associated force-producing protein that participates mitochondrial fission. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Functions antagonistically with FZO1. {ECO:0000269|PubMed:10559943, ECO:0000269|PubMed:23530241}. 3.6.5.5 Dynamin-related protein DNM1 (EC 3.6.5.5) "DNM1; dynamin-related GTPase DNM1" 3.6.5.5 DyNaMin-related "Mitochondrial recruitment of Drp1;Mitochondrial recruitment of Drp1" NA GTP + H2O = GDP + phosphate NA GTP + H2O = GDP + phosphate NA NA NA 5 out of 5 GTP + H(2)O = GDP + phosphate. GTP + H(2)O = GDP + phosphate YES Nucleotide Salvage Pathway from e.coli NA E450 NA NA Mitophagy - yeast NA Apoptotic execution phase NA "mitochondrial membrane;cytoplasm" "mitochondrion;mitochondrial membrane;peroxisome;cytoplasm" "mitochondrial membrane;cytoplasm" +559 YLL051C "Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels" 1.16.1.9 Putative ferric reductase with similarity to Fre2p Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol. Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol. {ECO:0000269|PubMed:17553781, ECO:0000269|PubMed:17681937}. 1.16.1.9 Ferric reductase transmembrane component 6 (EC 1.16.1.9) (Ferric-chelate reductase 6) "FRE6; putative ferric-chelate reductase" Ferric REductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" NA vacuolar membrane "vacuole;vacuolar membrane;cell envelope" vacuolar membrane +562 YLL058W "Putative protein of unknown function with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene" 2.5.1.48 Putative protein of unknown function with similarity to Str2p Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity). {ECO:0000250}. 2.5.1.48 Putative cystathionine gamma-synthase YLL058W (EC 2.5.1.48) (O-succinylhomoserine (thiol)-lyase) cystathionine gamma-synthase 2.5.1.48 Unknown "O-succinyl-L-homoserine + L-cysteine => L-cystathionine + H(+) + succinate;L-cystathionine + H(+) + succinate => O-succinyl-L-homoserine + L-cysteine" "O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate;O-succinyl-L-homoserine + H2O = succinate + 2-oxobutyrate + NH3;O-succinyl-L-homoserine + H2S = L-homocysteine + succinate;O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate;O-acetyl-L-homoserine + L-cysteine = L-cystathionine + acetate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate;O-succinyl-L-homoserine + L-cysteine = O-acetyl-L-homocysteine + L-cysteine;O-succinyl-L-homoserine + L-selenocysteine = selenocystathionine + succinate" "O-succinyl-L-homoserine + L-cysteine => L-cystathionine + H(+) + succinate;L-cystathionine + H(+) + succinate => O-succinyl-L-homoserine + L-cysteine" "O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate;O-succinyl-L-homoserine + H2O = succinate + 2-oxobutyrate + NH3;O-succinyl-L-homoserine + H2S = L-homocysteine + succinate;O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate;O-acetyl-L-homoserine + L-cysteine = L-cystathionine + acetate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate;O-succinyl-L-homoserine + L-cysteine = O-acetyl-L-homocysteine + L-cysteine;O-succinyl-L-homoserine + L-selenocysteine = selenocystathionine + succinate" "O-Succinyl-L-homoserine + H2O <=> 2-Oxobutanoate + Succinate + Ammonia;O-Succinyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Succinate;Cystathionine + Succinate <=> O-Succinyl-L-homoserine + L-Cysteine;O-Acetyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Acetate;O-Succinyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Succinate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate" 3 out of 5 O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate. "L-cysteine + O-succinyl-L-homoserine => succinate + L-cystathionine + H+;O-succinyl-L-homoserine + H2O => 2-oxobutanoate + succinate + ammonium + H+" YES Cysteine and methionine metabolism pathway from kegg E470 "PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1." "Cysteine and methionine metabolism;Selenocompound metabolism;Sulfur metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Biosynthesis of amino acids" "Cysteine and methionine metabolism;path:map00270;Selenocompound metabolism;path:map00450;Sulfur metabolism;path:map00920;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Biosynthesis of antibiotics;path:map01130" cytoplasm +563 YLL060C "Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress" 2.5.1.18 Glutathione S-transferase capable of homodimerization NA 2.5.1.18 Glutathione S-transferase 2 (EC 2.5.1.18) (GST-II) "GTT2; glutathione transferase GTT2" NA glutathione transferase NA "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+;glutathione + 4-hydroxy-2-nonenal = 4-hydroxy-2-nonenal-glutathione conjugate;glutathione + RX = a glutathione-toxin conjugate + HX" NA NA 4 out of 5 RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:19851333}. RX + glutathione = HX + R-S-glutathione YES Glutathione metabolism "pathway from kegg; reaction from uniprot" "H675;H1101" glutathione-glutaredoxin redox reactions NA NA NA NA "Glutathione metabolism;path:map00480;Metabolism of xenobiotics by cytochrome P450;path:map00980;Drug metabolism - cytochrome P450;path:map00982" mitochondrion +567 YLR047C "Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p" 1.16.1.7 Protein with sequence similarity to iron/copper reductases Required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates (By similarity). Involved in iron homeostasis. {ECO:0000250, ECO:0000269|PubMed:14534306}. 1.16.1.7 Probable ferric reductase transmembrane component 8 (EC 1.16.1.7) (Ferric-chelate reductase 8) "FRE8; putative ferric-chelate reductase" FRE8 "2 a Fe(II)-siderophore + H(+) + NAD(+) => 2 a Fe(III)-siderophore + NADH;2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)" "2 Fe(II)-siderophore + NAD+ + H+ = 2 Fe(III)-siderophore + NADH;NADH + Fe3+ = NAD+ + Fe2+" "2 a Fe(II)-siderophore + H(+) + NAD(+) => 2 a Fe(III)-siderophore + NADH;2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)" "2 Fe(II)-siderophore + NAD+ + H+ = 2 Fe(III)-siderophore + NADH;NADH + Fe3+ = NAD+ + Fe2+" 4 out of 5 2 Fe(II)-siderophore + NAD(+) + H(+) = 2 Fe(III)-siderophore + NADH. 2 a Fe(III)-siderophore + NADPH <=> 2 a Fe(II)-siderophore + H(+) + NADP(+) YES ferric-chelate reductase no pathway from database NA "vacuole;endoplasmic reticulum" +568 YLR057W "Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene" 3.2.1.- Putative mannosidase involved in ER-associated protein degradation Putative mannosidase involved in glycoprotein quality control since it is involved in the targeting of misfolded glycoproteins for ER-associated protein degradation (ERAD). {ECO:0000269|PubMed:21971548}. 3.2.1.- Putative endoplasmic reticulum mannosidase MNL2 (EC 3.2.1.-) (Mannosidase-like protein 2) "MNL2; putative mannosidase MNL2" 3.2.1.113 MaNnosidase-Like protein "G00011 + 4 H2O <=> G00012 + 4 D-Mannose;H2O + G00011 <=> D-Mannose + G10694" 4 out of 5 NA "G00011 + 4 H2O <=> G00012 + 4 D-Mannose;H2O + G00011 <=> D-Mannose + G10694" YES N-Glycan biosynthesis pathway from kegg "PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P32906}." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" NA endoplasmic reticulum membrane "Golgi membrane;endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +571 YLR099C "Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication; human ABHD5 can complement ict1 null mutant" 2.3.1.51 Lysophosphatidic acid acyltransferase Lysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper. {ECO:0000269|PubMed:10628851, ECO:0000269|PubMed:11055939, ECO:0000269|PubMed:18252723, ECO:0000269|PubMed:9717239}. 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase ICT1 (EC 2.3.1.51) (Increased copper tolerance protein 1) (Lysophosphatidic acid acyltransferase ICT1) (LPAAT) "ICT1; lysophosphatidic acid acyltransferase ICT1" Increased Copper Tolerance ABHD4 hydrolyses NAPE "1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA;a 1,2-diacyl-sn-glycero-3-phosphate + CoA => 1-acyl-sn-glycero-3-phosphate + an acyl-CoA" "acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate;palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate;acyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate;1-oleoyl-sn-glycerol-3-phosphate + oleoyl-CoA = CoA + 1,2-oleoyl-sn-glycerol-3-phosphate;2,3-Dehydroacyl-CoA + 1-Acyl-sn-glycerol 3-phosphate <=> CoA + Phosphatidate;palmitoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];long-chain acyl-[acyl-carrier protein] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl 2-acyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];stearoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-stearoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];oleoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];18-hydroxylinoleoyl-CoA + 1-[18-hydroxyoleyl]-2-lyso-phosphatidate = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + coenzyme A;palmitoleoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-CoA + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];myristoyl-CoA + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + coenzyme A;myristoyl-[acp] + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + holo-[acyl-carrier protein];1-palmitoylglycerol 3-phosphate + myristoyl-CoA = 1-palmitoyl-2-myristoyl phosphatidate + coenzyme A;1-palmitoylglycerol 3-phosphate + myristoyl-[acp] = 1-palmitoyl-2-myristoyl phosphatidate + holo-[acyl-carrier protein];long-chain acyl-CoA + 1-alkyl-sn-glycerol 3-phosphate = 2-acyl-1-alkyl-sn-glycerol 3-phosphate + coenzyme A;2,3,4-saturated fatty acyl-[acp] + 2,3,4-saturated 2-lysophosphatidate = 2,3,4-saturated L-phosphatidate + holo-[acyl-carrier protein];palmitoyl-[acp] + 1-palmitoylglycerol 3-phosphate = dipalmitoyl phosphatidate + holo-[acyl-carrier protein];oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol = CoA + 1,2-dioleoyl-sn-phosphatidylinositol;myristoyl-CoA + 1-myristoyl-sn-glycerol 3-phosphate = CoA + 1,2-dimyristoyl-sn-glycerol 3-phosphate;lauroyl-CoA + 1-lauroyl-sn-glycerol 3-phosphate = CoA + 1,2-dilauroyl-sn-glycerol 3-phosphate;arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate" "1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA;a 1,2-diacyl-sn-glycero-3-phosphate + CoA => 1-acyl-sn-glycero-3-phosphate + an acyl-CoA" "acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate;palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate;acyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate;1-oleoyl-sn-glycerol-3-phosphate + oleoyl-CoA = CoA + 1,2-oleoyl-sn-glycerol-3-phosphate;2,3-Dehydroacyl-CoA + 1-Acyl-sn-glycerol 3-phosphate <=> CoA + Phosphatidate;palmitoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];long-chain acyl-[acyl-carrier protein] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl 2-acyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];stearoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-stearoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];oleoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];18-hydroxylinoleoyl-CoA + 1-[18-hydroxyoleyl]-2-lyso-phosphatidate = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + coenzyme A;palmitoleoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-CoA + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];myristoyl-CoA + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + coenzyme A;myristoyl-[acp] + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + holo-[acyl-carrier protein];1-palmitoylglycerol 3-phosphate + myristoyl-CoA = 1-palmitoyl-2-myristoyl phosphatidate + coenzyme A;1-palmitoylglycerol 3-phosphate + myristoyl-[acp] = 1-palmitoyl-2-myristoyl phosphatidate + holo-[acyl-carrier protein];long-chain acyl-CoA + 1-alkyl-sn-glycerol 3-phosphate = 2-acyl-1-alkyl-sn-glycerol 3-phosphate + coenzyme A;2,3,4-saturated fatty acyl-[acp] + 2,3,4-saturated 2-lysophosphatidate = 2,3,4-saturated L-phosphatidate + holo-[acyl-carrier protein];palmitoyl-[acp] + 1-palmitoylglycerol 3-phosphate = dipalmitoyl phosphatidate + holo-[acyl-carrier protein];oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol = CoA + 1,2-dioleoyl-sn-phosphatidylinositol;myristoyl-CoA + 1-myristoyl-sn-glycerol 3-phosphate = CoA + 1,2-dimyristoyl-sn-glycerol 3-phosphate;lauroyl-CoA + 1-lauroyl-sn-glycerol 3-phosphate = CoA + 1,2-dilauroyl-sn-glycerol 3-phosphate;arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate" ABHD4 hydrolyses NAPE 3 out of 5 Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate <=> CoA + 1,2-diacyl-sn-glycerol 3-phosphate YES "Glycerolipid metabolism;Glycerophospholipid metabolism" pathway from kegg "E705;H70;H787" Acyl chain remodelling of PE "Glycerolipid metabolism;path:map00561;Glycerophospholipid metabolism;path:map00564;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" +576 YLR143W "Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene" 6.3.1.14 Diphthamide synthetase Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EFT1 or EFT2) to diphthamide. {ECO:0000269|PubMed:23169644, ECO:0000269|PubMed:23468660}. 6.3.1.14 Diphthine--ammonia ligase (EC 6.3.1.14) (Diphthamide synthase) (Diphthamide synthetase) "DPH6; diphthine--ammonia ligase" 6.3.1.14 "diphthine—ammonia ligase" DPH6 ligates ammonium to diphthine-EEF2 "ATP + diphthine-[translation elongation factor 2] + NH4(+) => AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+);AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) => ATP + diphthine-[translation elongation factor 2] + NH4(+)" ATP + Peptide diphthine + Ammonia + H+ <=> AMP + Diphosphate + Peptide diphthamide "ATP + diphthine-[translation elongation factor 2] + NH4(+) => AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+);AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) => ATP + diphthine-[translation elongation factor 2] + NH4(+)" ATP + Peptide diphthine + Ammonia + H+ <=> AMP + Diphosphate + Peptide diphthamide a diphthine-[translation elongation factor 2] + ammonium + ATP => a diphthamide-[translation elongation factor 2] + AMP + diphosphate + H+ ATP + Peptide diphthine + Ammonia + H+ <=> AMP + Diphosphate + Peptide diphthamide 4 out of 5 ATP + diphthine-[translation elongation factor 2] + NH(3) = AMP + diphosphate + diphthamide-[translation elongation factor 2]. {ECO:0000269|PubMed:23169644}. ATP + Peptide diphthine + Ammonia + H+ <=> AMP + Diphosphate + Peptide diphthamide YES diphthamide biosynthesis pathway from biocyc "PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. {ECO:0000269|PubMed:23169644}." diphthamide biosynthesis Synthesis of diphthamide-EEF2 NA cytoplasm cytoplasm cytoplasm +578 YLR151C "8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1" 3.6.1.55 8-oxo-dGTP diphosphatase " Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine. Has a strong preference for oxidized CoA disulfide (CoASSCoA) as substrate. May be required to remove potentially toxic oxidized CoA disulfide to maintain the capacity for beta-oxidation of fatty acids. Can degrade 8-oxo-dGTP in vitro; however, such activity may not be relevant in vivo." 3.6.1.55 Peroxisomal coenzyme A diphosphatase 1, peroxisomal (EC 3.6.1.55) "PCD1; 8-oxo-dGTP diphosphatase" NA peroxisomal nudix hydrolase NA "8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+);8-oxo-dGMP + diphosphate + H(+) => 8-oxo-dGTP + H2O" "8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate;GTP + H2O = GMP + diphosphate;dGTP + H2O = dGMP + diphosphate;8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate;8-oxo-GDP + H2O = 8-oxo-GMP + phosphate;dGDP + H2O = dGMP + phosphate" "8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+);8-oxo-dGMP + diphosphate + H(+) => 8-oxo-dGTP + H2O" "8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate;GTP + H2O = GMP + diphosphate;dGTP + H2O = dGMP + diphosphate;8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate;8-oxo-GDP + H2O = 8-oxo-GMP + phosphate;dGDP + H2O = dGMP + phosphate" NA NA NA 5 out of 5 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate. {ECO:0000269|PubMed:10922370}. 8-oxo-dGTP + H(2)O <=> 8-oxo-dGMP + diphosphate YES other NA NA NA NA NA NA NA NA peroxisome "peroxisome;cytoplasm" peroxisome +580 YLR164W "Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p" Putative alternate subunit of succinate dehydrogenase (SDH) Homolog of SDH4, but seems not to be a stoichiometric subunit of either the succinate dehydrogenase (SDH) complex or the mitochondrial inner membrane translocase TIM22 complex. {ECO:0000303|PubMed:22152483}. Mitochondrial inner membrane protein SHH4 (SDH4 homolog) "SHH4; protein SHH4" SDH4 Homolog Quinone + Succinate <=> Hydroquinone + Fumarate 4 out of 5 NA Quinone + Succinate <=> Hydroquinone + Fumarate YES Citrate cycle (TCA cycle) pathway from kegg "Citrate cycle (TCA cycle);Oxidative phosphorylation;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism" NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +587 YLR214W "Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels" 1.16.1.9 Ferric reductase and cupric reductase Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake. {ECO:0000269|PubMed:11120744, ECO:0000269|PubMed:12954629, ECO:0000269|PubMed:1431884, ECO:0000269|PubMed:1570306, ECO:0000269|PubMed:7814363, ECO:0000269|PubMed:8662826, ECO:0000269|PubMed:8662973, ECO:0000269|PubMed:9153234}. 1.16.1.9 Ferric/cupric reductase transmembrane component 1 (EC 1.16.1.9) (Ferric-chelate reductase 1) "FRE1; ferric/cupric-chelate reductase" ferric reductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+;2 an Fe(III)-siderophore + NADPH => 2 Fe2+ + 2 a siderophore + NADP+ + H+;2 ferric (2,3-dihydroxybenzoylserine)3 + NADPH + 9 H+ => 2 Fe2+ + 2 (2,3-dihydroxybenzoylserine)3 + NADP+" 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. {ECO:0000269|PubMed:11120744, ECO:0000269|PubMed:1431884, ECO:0000269|PubMed:15288128, ECO:0000269|PubMed:8662826, ECO:0000269|PubMed:8662973}. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope cell envelope cell envelope +590 YLR239C "Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups" 2.3.1.181 Lipoyl ligase Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). {ECO:0000250}. 2.3.1.181 Octanoyltransferase, mitochondrial (EC 2.3.1.181) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase) "LIP2; lipoyl(octanoyl) transferase LIP2" 2.3.1.181 octanoyl transferase LIPT2 transfers octanoyl group to GCSH "[protein]-L-lysine + octanoyl-[ACP] => [protein]-N(6)-octanoyl-L-lysine + H(+) + holo-[ACP];[protein]-N(6)-octanoyl-L-lysine + H(+) + holo-[ACP] => [protein]-L-lysine + octanoyl-[ACP]" "octanoyl-[acyl-carrier protein] + protein = protein 6-N-(octanoyl)lysine + acyl carrier protein;Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein;octanoyl-[acp] + [glycine cleavage system lipoyl-carrier protein]-L-lysine = [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + holo-[acyl-carrier protein] + H+;octanoyl-[acp] + [lipoyl-carrier protein]-L-lysine = [lipoyl-carrier protein] N6-octanoyl-L-lysine + holo-[acyl-carrier protein] + H+;an octanoyl-[acyl-carrier protein] + glycine cleavage system protein = glycine cleavage system protein-N6-(octanoyl)lysine + an [acyl-carrier protein];octanoyl-[acyl-carrier protein] + apo-H protein = APO H-protein N6-(octanoyl)lysine + acyl-carrier protein" "[protein]-L-lysine + octanoyl-[ACP] => [protein]-N(6)-octanoyl-L-lysine + H(+) + holo-[ACP];[protein]-N(6)-octanoyl-L-lysine + H(+) + holo-[ACP] => [protein]-L-lysine + octanoyl-[ACP]" "octanoyl-[acyl-carrier protein] + protein = protein 6-N-(octanoyl)lysine + acyl carrier protein;Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein;octanoyl-[acp] + [glycine cleavage system lipoyl-carrier protein]-L-lysine = [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + holo-[acyl-carrier protein] + H+;octanoyl-[acp] + [lipoyl-carrier protein]-L-lysine = [lipoyl-carrier protein] N6-octanoyl-L-lysine + holo-[acyl-carrier protein] + H+;an octanoyl-[acyl-carrier protein] + glycine cleavage system protein = glycine cleavage system protein-N6-(octanoyl)lysine + an [acyl-carrier protein];octanoyl-[acyl-carrier protein] + apo-H protein = APO H-protein N6-(octanoyl)lysine + acyl-carrier protein" "an octanoyl-[acp] + a [lipoyl-carrier protein]-L-lysine => a [lipoyl-carrier protein] N6-octanoyl-L-lysine + a holo-[acyl-carrier protein] + H+;an octanoyl-[acp] + [glycine cleavage system lipoyl-carrier protein]-L-lysine => a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + a holo-[acyl-carrier protein] + H+" "Octanoyl-[acp] + Apoprotein <=> Protein N6-(octanoyl)lysine + Acyl-carrier protein;Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein" NA 4 out of 5 Octanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein]. "Octanoyl-[acp] + Apoprotein <=> Protein N6-(octanoyl)lysine + Acyl-carrier protein;Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein" YES Lipoic acid metabolism pathway from kegg "H1034;H1035" NA "PATHWAY: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2." "Lipoic acid metabolism;Metabolic pathways" superpathway of lipoate biosynthesis and incorporation (PDH, KGDH, GCV) // lipoate biosynthesis and incorporation (glycine cleavage system) // lipoate biosynthesis and incorporation I Glyoxylate metabolism and glycine degradation "Lipoic acid metabolism;path:map00785;Metabolic pathways;path:map01100" mitochondrion mitochondrion mitochondrion +591 YLR244C "Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p" 3.4.11.18 Methionine aminopeptidase Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays the major role in N-terminal methionine removal. Less efficient when the second residue is Val. {ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:11811952, ECO:0000269|PubMed:11968008, ECO:0000269|PubMed:12874831, ECO:0000269|PubMed:7862096}. 3.4.11.18 Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1) "MAP1; methionine aminopeptidase MAP1" 3.4.11.18 methionine aminopeptidase METAP1/2 demethylates GNAT1 "Met-Ala + H2O = Met + Ala;N-terminal-L-methionyl-L-alanyl-[protein] + H2O = N-terminal L-alanyl-[protein] + L-methionine;N-terminal-L-methionyl-L-cysteinyl-[protein] + H2O = N-terminal cysteinyl-[protein] + L-methionine;N-terminal-L-methionyl-glycyl-[protein] + H2O = N-terminal glycyl-[protein] + L-methionine;N-terminal-L-methionyl-L-seryl-[protein] + H2O = N-terminal L-seryl-[protein] + L-methionine;N-terminal-L-methionyl-L-threonyl-[protein] + H2O = N-terminal L-threonyl-[protein] + L-methionine;N-terminal-L-methionyl-L-valyl-[protein] + H2O = N-terminal L-valyl-[protein] + L-methionine;Met-peptide + H2O = Met + peptide" "Met-Ala + H2O = Met + Ala;N-terminal-L-methionyl-L-alanyl-[protein] + H2O = N-terminal L-alanyl-[protein] + L-methionine;N-terminal-L-methionyl-L-cysteinyl-[protein] + H2O = N-terminal cysteinyl-[protein] + L-methionine;N-terminal-L-methionyl-glycyl-[protein] + H2O = N-terminal glycyl-[protein] + L-methionine;N-terminal-L-methionyl-L-seryl-[protein] + H2O = N-terminal L-seryl-[protein] + L-methionine;N-terminal-L-methionyl-L-threonyl-[protein] + H2O = N-terminal L-threonyl-[protein] + L-methionine;N-terminal-L-methionyl-L-valyl-[protein] + H2O = N-terminal L-valyl-[protein] + L-methionine;Met-peptide + H2O = Met + peptide" a peptide with an N-terminal L-methionine + H2O => L-methionine + a peptide + H+ 5 out of 5 Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. {ECO:0000255|HAMAP-Rule:MF_03174}. Met-Ala + H2O <=> Met + Ala YES Hydrolysis of peptide bond no pathway from database Inactivation, recovery and regulation of the phototransduction cascade NA cytoplasm cytoplasm cytoplasm +597 YLR286C "Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p" 3.2.1.14 Endochitinase Chitinase is required for cell separation during growth of Saccharomyces cerevisiae. 3.2.1.14 Endochitinase (EC 3.2.1.14) (Soluble cell wall protein 2) "CTS1, SCW2; Cts1p" 3.2.1.14 endochitinase "GlcNAc beta(1-4)GlcNAc + H2O = N-acetyl-D-glucosamine + N-acetyl-D-glucosamine;Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin;beta-1,4-Poly-N-acetyl-D-glucosamine(n+2) + H2O <=> Chitobiose + beta-1,4-Poly-N-acetyl-D-glucosamine(n);N,N',N'',N''',N''''-pentaacetylchitopentaose + H2O = N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;solid beta-chitin + H2O = N,N'-diacetylchitobiose;N-acetylglucosamine oligomers + H2O = N-acetylglucosamine;chitosan + H2O = chitosan oligosaccharides;chitopentaose + H2O = chitobiose + chitotriose" "GlcNAc beta(1-4)GlcNAc + H2O = N-acetyl-D-glucosamine + N-acetyl-D-glucosamine;Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin;beta-1,4-Poly-N-acetyl-D-glucosamine(n+2) + H2O <=> Chitobiose + beta-1,4-Poly-N-acetyl-D-glucosamine(n);N,N',N'',N''',N''''-pentaacetylchitopentaose + H2O = N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;solid beta-chitin + H2O = N,N'-diacetylchitobiose;N-acetylglucosamine oligomers + H2O = N-acetylglucosamine;chitosan + H2O = chitosan oligosaccharides;chitopentaose + H2O = chitobiose + chitotriose" "a chitodextrin + n H2O => n N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose;chitin + H2O => 2 a chitodextrin" "Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin" 5 out of 5 Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. "Chitin + H2O <=> N-Acetyl-D-glucosamine + Chitin;Chitin + H2O <=> Chitobiose + Chitin" YES Amino sugar and nucleotide sugar metabolism pathway from kegg "H142;H1198" "Amino sugar and nucleotide sugar metabolism;Metabolic pathways" "Amino sugar and nucleotide sugar metabolism;path:map00520;Metabolic pathways;path:map01100" cell envelope "vacuole;extracellular;cell envelope;nucleus;endoplasmic reticulum" cell envelope +601 YLR345W "Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene" "2.7.1.105;3.1.3.46" Similar to 6-phosphofructo-2-kinase enzymes Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000250}. "2.7.1.105; 3.1.3.46" "Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase "2.7.1.105;3.1.3.46" putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase "beta-D-fructose 6-phosphate + ATP => beta-D-fructose 2,6-bisphosphate + ADP + H(+);beta-D-fructose 2,6-bisphosphate + ADP + H(+) => beta-D-fructose 6-phosphate + ATP;beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate;beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O" "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate;beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate" "beta-D-fructose 6-phosphate + ATP => beta-D-fructose 2,6-bisphosphate + ADP + H(+);beta-D-fructose 2,6-bisphosphate + ADP + H(+) => beta-D-fructose 6-phosphate + ATP;beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate;beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O" "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate;beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate" beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructofuranose 6-phosphate + phosphate 4 out of 5 "Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.; ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate." "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 2,6-bisphosphate;beta-D-fructose 2,6-bisphosphate + H2O <=> D-fructose 6-phosphate + phosphate" YES Fructose and mannose metabolism pathway from kegg "H459;NA" Fructose and mannose metabolism fructose 2,6-bisphosphate biosynthesis "Fructose and mannose metabolism;path:map00051;NA" cytoplasm cytoplasm cytoplasm +602 YLR351C "Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" 3.5.-.- Nit protein Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively. {ECO:0000269|PubMed:28373563}. 3.5.1.3 Omega-amidase NIT3 (EC 3.5.1.3) (Nitrilase homolog 2) "NIT3; putative hydrolase" NA nitrilase "Exocytosis of tertiary granule lumen proteins;Exocytosis of tertiary granule lumen proteins;Exocytosis of specific granule lumen proteins;Exocytosis of specific granule lumen proteins" NA NA "a monoamide of a dicarboxylate + H2O => a dicarboxylate + NH4(+);a dicarboxylate + NH4(+) => a monoamide of a dicarboxylate + H2O" "a monocarboxylic acid amide + H2O = a monocarboxylate + NH3;2-oxoglutaramate + H2O = 2-oxoglutarate + NH3;2-oxosuccinamate + H2O = 2-oxosuccinate + NH3;a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH3;glutaramic acid + H2O = glutaric acid + NH3;Monoamide of dicarboxylate + H2O <=> Dicarboxylate + Ammonia;monoamide of a dicarboxylate + H2O = dicarboxylate + ammonium" "a nitrile + 2 H2O = a carboxylate + ammonium;indole-3-acetonitrile + 2 H2O => ammonium + indole-3-acetate" NA NA 4 out of 5 A monoamide of a dicarboxylate + H(2)O = a dicarboxylate + NH(3). {ECO:0000269|PubMed:28373563}. a monoamide of a dicarboxylate + H2O <=> a dicarboxylate + NH4(+) YES urea cycle "h2o[c] + 2-Oxoglutaramate[c] -> nh4[c] + akg[c] from human; subsystem from human" H590 NA NA NA indole-3-acetate biosynthesis V (bacteria and fungi) Neutrophil degranulation "Alanine, aspartate and glutamate metabolism;path:map00250" "cytoplasm;mitochondrion" +604 YLR369W "Mitochondrial hsp70-type molecular chaperone; required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia" Mitochondrial hsp70-type molecular chaperone Has a role in mitochondrial iron homeostasis. Appears to be involved in the processing of the intermediate form of the frataxin homolog YFH1. Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. {ECO:0000269|PubMed:10779357, ECO:0000269|PubMed:11273703, ECO:0000269|PubMed:12756240, ECO:0000269|PubMed:15123690, ECO:0000269|PubMed:15958384, ECO:0000269|PubMed:16431909, ECO:0000269|PubMed:9660806}. Heat shock protein SSQ1, mitochondrial (Stress-seventy subfamily Q protein 1) (mtHSP70 homolog) "SSQ1, SSC2, SSH1; Hsp70 family ATPase SSQ1" chaperone for [Fe-S] cluster biosynthesis "a [chaperone-ADP]-[disordered-form scaffold protein] complex + ATP => an [Fe-S cluster biosynthesis chaperone]-ATP + a [disordered-form [Fe-S] cluster scaffold protein] + ADP;a [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex + an apo-iron-sulfur protein => a [chaperone-ADP]-[disordered-form scaffold protein] complex + an [Fe-S cluster biosynthesis co-chaperone] + an [2Fe-2S] cluster protein + phosphate;a [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + an [Fe-S cluster biosynthesis chaperone]-ATP => a [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex" 5 out of 5 NA "a [chaperone-ADP]-[disordered-form scaffold protein] complex + ATP => an [Fe-S cluster biosynthesis chaperone]-ATP + a [disordered-form [Fe-S] cluster scaffold protein] + ADP;a [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex + an apo-iron-sulfur protein => a [chaperone-ADP]-[disordered-form scaffold protein] complex + an [Fe-S cluster biosynthesis co-chaperone] + an [2Fe-2S] cluster protein + phosphate;a [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + an [Fe-S cluster biosynthesis chaperone]-ATP => a [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex" YES iron-sulfur cluster biosynthesis "Mitochondrial hsp70-type molecular chaperone; pathway from biocyc" RNA degradation iron-sulfur cluster biosynthesis NA mitochondrion mitochondrion mitochondrion +605 YLR393W "Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6" Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase Essential for the assembly of the mitochondrial F1-F0 complex. Mitochondrial ATPase complex subunit ATP10 "ATP10; Atp10p" ATP synthase ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] 3 out of 5 NA ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] YES Oxidative phosphorylation pathway from kegg superpathway of purine nucleotides de novo biosynthesis I // adenosine nucleotides de novo biosynthesis // adenosine ribonucleotides de novo biosynthesis NA mitochondrial membrane "cytoplasm;mitochondrion;mitochondrial membrane" mitochondrial membrane +613 YLR446W "Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene" 2.7.1.1 Putative hexokinase 2.7.1.1 Putative hexokinase YLR446W (EC 2.7.1.1) hexokinase 2.7.1.1 Unknown "D-hexose + ATP => D-hexose 6-phosphate + ADP + H(+);D-hexose 6-phosphate + ADP + H(+) => D-hexose + ATP" "ATP + H2O = ADP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;ATP + D-hexose = ADP + D-hexose 6-phosphate;ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate;ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate;ATP + D-allose = ADP + D-allose 6-phosphate;ATP + D-arabinose = ADP + D-arabinose 5-phosphate;ATP + D-fructose = ADP + D-fructose 6-phosphate;ATP + D-mannose = ADP + D-mannose 6-phosphate;ITP + D-glucose = IDP + D-glucose 6-phosphate;2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate;dATP + D-fructose = dADP + D-fructose 6-phosphate;ITP + D-fructose = IDP + D-fructose 6-phosphate;ITP + D-mannose = IDP + D-mannose 6-phosphate;dATP + D-mannose = dADP + D-mannose 6-phosphate;ATP + beta-D-glucose = ADP + beta-D-glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate;ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ITP + D-Glucosamine <=> IDP + D-Glucosamine 6-phosphate;dATP + D-Glucosamine <=> dADP + D-Glucosamine 6-phosphate;ITP + D-Hexose <=> IDP + D-Hexose 6-phosphate;dATP + D-Hexose <=> dADP + D-Hexose 6-phosphate;ATP + D-Sorbitol <=> ADP + Sorbitol 6-phosphate;ITP + D-Sorbitol <=> IDP + Sorbitol 6-phosphate;dATP + D-Sorbitol <=> dADP + Sorbitol 6-phosphate;ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ATP + hexose = ADP + hexose 6-phosphate" "D-hexose + ATP => D-hexose 6-phosphate + ADP + H(+);D-hexose 6-phosphate + ADP + H(+) => D-hexose + ATP" "ATP + H2O = ADP + phosphate;2-Deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate;ATP + D-hexose = ADP + D-hexose 6-phosphate;ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate;ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate;ATP + D-allose = ADP + D-allose 6-phosphate;ATP + D-arabinose = ADP + D-arabinose 5-phosphate;ATP + D-fructose = ADP + D-fructose 6-phosphate;ATP + D-mannose = ADP + D-mannose 6-phosphate;ITP + D-glucose = IDP + D-glucose 6-phosphate;2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate;dATP + D-fructose = dADP + D-fructose 6-phosphate;ITP + D-fructose = IDP + D-fructose 6-phosphate;ITP + D-mannose = IDP + D-mannose 6-phosphate;dATP + D-mannose = dADP + D-mannose 6-phosphate;ATP + beta-D-glucose = ADP + beta-D-glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate;ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ITP + D-Glucosamine <=> IDP + D-Glucosamine 6-phosphate;dATP + D-Glucosamine <=> dADP + D-Glucosamine 6-phosphate;ITP + D-Hexose <=> IDP + D-Hexose 6-phosphate;dATP + D-Hexose <=> dADP + D-Hexose 6-phosphate;ATP + D-Sorbitol <=> ADP + Sorbitol 6-phosphate;ITP + D-Sorbitol <=> IDP + Sorbitol 6-phosphate;dATP + D-Sorbitol <=> dADP + Sorbitol 6-phosphate;ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ATP + hexose = ADP + hexose 6-phosphate" "a D-hexose + ATP = D-hexose 6-phosphate + ADP + H+;D-glucopyranose + ATP => D-glucopyranose 6-phosphate + ADP + H+" "ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate;ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ATP + D-Mannose <=> ADP + D-Mannose 6-phosphate;ATP + beta-D-Glucose <=> ADP + beta-D-Glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate;ATP + D-Glucosamine <=> ADP + D-Glucosamine 6-phosphate;ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate" 2 out of 5 ATP + D-hexose = ADP + D-hexose 6-phosphate. "ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate;ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate;ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate;ATP + D-Mannose <=> ADP + D-Mannose 6-phosphate;ATP + beta-D-Glucose <=> ADP + beta-D-Glucose 6-phosphate;ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate;ATP + D-Glucosamine <=> ADP + D-Glucosamine 6-phosphate;ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate" YES Glycolysis / Gluconeogenesis pathway from kegg "E155;E166;E388;H329;H1171" "Glycolysis / Gluconeogenesis;Fructose and mannose metabolism;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism" chitin biosynthesis // sucrose degradation III (sucrose invertase) // glycolysis III (from glucose) // trehalose degradation II (trehalase) // glucose-6-phosphate biosynthesis "Glycolysis / Gluconeogenesis;path:map00010;Fructose and mannose metabolism;path:map00051;Galactose metabolism;path:map00052;Starch and sucrose metabolism;path:map00500;Amino sugar and nucleotide sugar metabolism;path:map00520;Streptomycin biosynthesis;path:map00521;Neomycin, kanamycin and gentamicin biosynthesis;path:map00524;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" cytoplasm +621 YML019W "Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p" 2.4.99.18 Subunit of the oligosaccharyltransferase complex of the ER lumen Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Can participate in redox reactions and is able to catalyze dithiol-disulfide exchange reactions with other proteins, albeit with relatively low efficiency. May form transient disulfide bonds with nascent polypeptides in the endoplasmic reticulum and thereby promote efficient glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal oligosaccharyl transferase activity. {ECO:0000269|PubMed:19549845}. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6 (Oligosaccharyl transferase subunit OST6) (EC 2.4.99.18) (Oligosaccharyl transferase 37 kDa subunit) (OTase 37 kDa subunit) "OST6; dolichyl-diphosphooligosaccharide--protein glycotransferase" NA oligosaccharyl transferase complex OST6 subunit NA "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA NA 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps NA "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +630 YML082W "Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; not an essential gene; YML082W has a paralog, STR2, that arose from the whole genome duplication" 2.5.1.48 Putative protein predicted to have carbon-sulfur lyase activity Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity). {ECO:0000250}. 2.5.1.48 Putative cystathionine gamma-synthase YML082W (EC 2.5.1.48) (O-succinylhomoserine (thiol)-lyase) putative cystathionine gamma-synthase 2.5.1.48 "putative cystathionine γ-synthase YML082W" "O-succinyl-L-homoserine + L-cysteine => L-cystathionine + H(+) + succinate;L-cystathionine + H(+) + succinate => O-succinyl-L-homoserine + L-cysteine" "O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate;O-succinyl-L-homoserine + H2O = succinate + 2-oxobutyrate + NH3;O-succinyl-L-homoserine + H2S = L-homocysteine + succinate;O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate;O-acetyl-L-homoserine + L-cysteine = L-cystathionine + acetate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate;O-succinyl-L-homoserine + L-cysteine = O-acetyl-L-homocysteine + L-cysteine;O-succinyl-L-homoserine + L-selenocysteine = selenocystathionine + succinate" "O-succinyl-L-homoserine + L-cysteine => L-cystathionine + H(+) + succinate;L-cystathionine + H(+) + succinate => O-succinyl-L-homoserine + L-cysteine" "O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate;O-succinyl-L-homoserine + H2O = succinate + 2-oxobutyrate + NH3;O-succinyl-L-homoserine + H2S = L-homocysteine + succinate;O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate;O-acetyl-L-homoserine + L-cysteine = L-cystathionine + acetate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate;O-succinyl-L-homoserine + L-cysteine = O-acetyl-L-homocysteine + L-cysteine;O-succinyl-L-homoserine + L-selenocysteine = selenocystathionine + succinate" "L-cysteine + O-succinyl-L-homoserine => succinate + L-cystathionine + H+;O-succinyl-L-homoserine + H2O => 2-oxobutanoate + succinate + ammonium + H+" "O-Succinyl-L-homoserine + H2O <=> 2-Oxobutanoate + Succinate + Ammonia;O-Succinyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Succinate;Cystathionine + Succinate <=> O-Succinyl-L-homoserine + L-Cysteine;O-Acetyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Acetate;O-Succinyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Succinate;O-Phosphorylhomoserine + L-Selenocysteine <=> L-Selenocystathionine + Orthophosphate;O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate;O-Succinyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Succinate" 3 out of 5 O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate. "L-cysteine + O-succinyl-L-homoserine => succinate + L-cystathionine + H+;O-succinyl-L-homoserine + H2O => 2-oxobutanoate + succinate + ammonium + H+" YES Cysteine and methionine metabolism pathway from kegg E470 "PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1." "Cysteine and methionine metabolism;Selenocompound metabolism;Sulfur metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Biosynthesis of amino acids" superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) // cysteine biosynthesis IV (fungi) // homocysteine and cysteine interconversion "Cysteine and methionine metabolism;path:map00270;Selenocompound metabolism;path:map00450;Sulfur metabolism;path:map00920;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Biosynthesis of antibiotics;path:map01130" "nucleus;cytoplasm" +634 YML125C "Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication" 1.6.2.2 Putative cytochrome b5 reductase, localized to the plasma membrane NADH-dependent cytochrome b5 reductase that reduces coenzyme Q6 at the plasma membrane and mediates lifespan extension by calorie restriction by shifting fermentative to respiratory metabolism, probably through modulating the NAD(+)/NADH ratio. {ECO:0000269|PubMed:16943325, ECO:0000269|PubMed:19239415}. 1.6.2.2 Plasma membrane-associated coenzyme Q6 reductase PGA3 (EC 1.6.2.2) (Processing of GAS1 and ALP protein 3) "PGA3, NQR1; cytochrome-b5 reductase" 1.6.2.2 Processing of Gas1p and ALP CYB5Rs reduce MetHb to Hb "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" "2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+);2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH" "NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+;ferrihemoglobin + NADH = ferrohemoglobin + NAD+ + H+;methemoglobin + NADH = hemoglobin + NAD+;NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5" NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ CYB5Rs reduce MetHb to Hb 5 out of 5 NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5. {ECO:0000269|PubMed:19239415}. NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ YES Amino sugar and nucleotide sugar metabolism pathway from kegg H588 Amino sugar and nucleotide sugar metabolism Erythrocytes take up carbon dioxide and release oxygen "Amino sugar and nucleotide sugar metabolism;path:map00520" "cell envelope;endoplasmic reticulum membrane" "endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" "cell envelope;endoplasmic reticulum membrane" +643 YMR084W "Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1" 2.6.1.16 Putative protein of unknown function Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins). {ECO:0000250}. 2.6.1.16 Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing] (GFAT) (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (Hexosephosphate aminotransferase) putative glutamine--fructose-6-phosphate transaminase Unknown "D-fructofuranose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate;D-glucosamine 6-phosphate + L-glutamate => D-fructofuranose 6-phosphate + L-glutamine" L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate "D-fructofuranose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate;D-glucosamine 6-phosphate + L-glutamate => D-fructofuranose 6-phosphate + L-glutamine" L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate 3 out of 5 L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. L-glutamine + D-fructose 6-phosphate <=> L-glutamate + D-glucosamine 6-phosphate YES UDP-N-acetyl-alpha-D-glucosamine biosynthesis pathway from uniprot "E417;H276" "PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1." "Alanine, aspartate and glutamate metabolism;path:map00250;Amino sugar and nucleotide sugar metabolism;path:map00520;Metabolic pathways;path:map01100;Biosynthesis of antibiotics;path:map01130" +644 YMR087W "Putative ADP-ribose-1''-monophosphatase; converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain" 3.1.3.84 Putative ADP-ribose-1''-monophosphatase Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. + phosphate. 3.1.3.84 Probable ADP-ribose 1''-phosphate phosphatase YML087W (EC 3.1.3.84) putative ADP-ribose 1''-phosphate phosphatase YMR087W "ADP-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate;ADP-D-ribose + phosphate => ADP-D-ribose 1''-phosphate + H2O" ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate "ADP-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate;ADP-D-ribose + phosphate => ADP-D-ribose 1''-phosphate + H2O" ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate 4 out of 5 ADP-D-ribose 1''-phosphate + H(2)O = ADP-D-ribose + phosphate. ADP-D-ribose 1''-phosphate + H2O <=> ADP-D-ribose + phosphate YES other NA +645 YMR099C "Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS" 5.1.3.15 Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase) Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P). {ECO:0000269|PubMed:16857670}. 5.1.3.15 Glucose-6-phosphate 1-epimerase (EC 5.1.3.15) (D-hexose-6-phosphate mutarotase) glucose-6-phosphate 1-epimerase 5.1.3.15 D-glucose 6-phosphate 1-epimerase "alpha-D-glucose 6-phosphate => beta-D-glucose 6-phosphate;beta-D-glucose 6-phosphate => alpha-D-glucose 6-phosphate" alpha-D-Glucose 6-phosphate = beta-D-glucose 6-phosphate "alpha-D-glucose 6-phosphate => beta-D-glucose 6-phosphate;beta-D-glucose 6-phosphate => alpha-D-glucose 6-phosphate" alpha-D-Glucose 6-phosphate = beta-D-glucose 6-phosphate "alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate;alpha-D-glucose 6-phosphate <=> beta-D-glucose 6-phosphate;alpha-D-mannopyranose 6-phosphate <=> beta-D-mannopyranose 6-phosphate" alpha-D-Glucose 6-phosphate <=> beta-D-Glucose 6-phosphate 4 out of 5 Alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate. {ECO:0000269|PubMed:16857670}. alpha-D-Glucose 6-phosphate <=> beta-D-Glucose 6-phosphate YES Glycolysis / Gluconeogenesis pathway from kegg "Glycolysis / Gluconeogenesis;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics" UDP-glucose biosynthesis "Glycolysis / Gluconeogenesis;path:map00010;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" "nucleus;cytoplasm" +648 YMR110C "Dehydrogenase involved in ubiquinone and sphingolipid metabolism; oxidizes 4-hydroxybenzaldehyde into 4-hydroxybenzoic acid in ubiquinone biosynthesis; converts hexadecenal to hexadecenoic acid in sphingosine 1-phosphate breakdown pathway; located in the mitochondrial outer membrane and also in lipid particles; human homolog ALDH3A2, a fatty aldehyde dehydrogenase (FALDH) mutated in neurocutaneous disorder Sjogren-Larsson syndrome, can complement yeast hfd1 mutant" 1.2.1.3 Dehydrogenase involved in ubiquinone and sphingolipid metabolism Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. {ECO:0000269|PubMed:22633490}. 1.2.1.3 Fatty aldehyde dehydrogenase HFD1 (EC 1.2.1.3) "HFD1; hexadecenal dehydrogenase" 1.2.1.3 Homolog of Fatty aldehyde Dehydrogenase "ALDH3A2-2 oxidizes pristanal to pristanate;ALDH3A2-1 oxidises HD2NAL to PALM;ALD3A1 oxidises 4HPCP to CXPA;ALDH3B1 oxidises HXAL to PALM;Exocytosis of secretory granule membrane proteins;Exocytosis of secretory granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;ALDH3B2 oxidises HXAL to PALM" "an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH;a carboxylate + 2 H(+) + NADH => an aldehyde + H2O + NAD(+);acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH;acetate + 2 H(+) + NADH => acetaldehyde + H2O + NAD(+)" "succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+;4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + H+;(S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+;2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+;an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+;4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH + 2 H+;4-guanidinobutanal + NAD+ + H2O = 4-guanidinobutanoate + NADH + H+;salicylaldehyde + NAD+ + H2O = salicylate + NADH + 2 H+;benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+;Aldehyde + NAD+ + H2O <=> Carboxylate + NADH + H+;glycolaldehyde + NAD+ + H2O = glycolate + NADH + H+;retinal + NAD+ + H2O = retinoate + NADH + H+;phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+;a long-chain aldehyde + NAD+ + H2O = a long-chain carboxylate + NADH + H+;betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+;(2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+;geranial + H2O + NAD+ = geranate + NADH + H+;D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + 2 H+;3-aminopropanal + NAD+ + H2O = 3-aminopropanoate + NADH + H+;propionaldehyde + NAD+ + H2O = propionate + NADH + H+;acetaldehyde + NAD+ + H2O = acetate + NADH + H+;2-oxoglutaric semialdehyde + NAD+ + H2O = 2-oxoglutarate + NADH;D-lactaldehyde + NAD+ + H2O = D-lactate + NADH + H+;p-nitrobenzaldehyde + NAD+ + H2O = p-nitrobenzoate + NADH;octanal + NAD+ + H2O = octanoate + NADH + H+;decanal + NAD+ + H2O = decanoate + NADH;dodecanal + NAD+ + H2O = dodecanoate + NADH;monochloroacetaldehyde + NAD+ + H2O = monochloroacetate + NADH;3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O = 3,4-dihydroxyphenylacetate + NADH + H+;N-acetyl-4-aminobutyraldehyde + NAD+ + H2O = N-acetyl-4-aminobutyrate + NADH;p-methylbenzaldehyde + NAD+ + H2O = p-methylbenzoate + NADH;m-methylbenzaldehyde + NAD+ + H2O = m-methylbenzoate + NADH;indole-3-acetaldehyde + NAD+ + H2O = indole-3-acetate + NADH + H+;3,4-dihydroxymandelic aldehyde + NAD+ + H2O = 3,4-dihydroxymandelate + NADH;5-hydroxyindol acetaldehyde + NAD+ + H2O = 5-hydroxyindol acetate + NADH;acetaldehyde + NADP+ + H2O = acetate + NADPH + H+;propanal + beta-NADP+ + H2O = propionate + beta-NADPH + H+;perillaldehyde + NAD+ + H2O = perillic acid + NADH;octadecanal + NAD+ + H2O = octadecanoic acid + NADH;(S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+;phytenal + NAD+ + H2O = phytenate + NADH + H+;4-aminobutyraldehyde + NADP+ + H2O = 4-aminobutanoate + NADPH;syringaldehyde + NAD+ + H2O = syringic acid + NADH;3-hydroxypropionaldehyde + NAD+ + H2O = 3-hydroxypropanoate + NADH + 2 H+;glyceryl trinitrate + NADH + H+ = 1,3-glyceryl dinitrate + nitrite + NAD+;phosphonoacetaldehyde + NAD+ + H2O = phosphonoacetate + NADH + H+;formaldehyde + NAD+ + H2O = formate + NADH + H+;3-hydroxybenzaldehyde + NAD+ + H2O = 3-hydroxybenzoate + NADH + H+;4-hydroxyphenyl-3-methoxyglycolaldehyde + NAD+ + H2O = 4-hydroxyphenyl-3-methoxyglycolate + NADH;2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH;3-methoxy-4-hydroxyphenylacetaldehyde + NAD+ + H2O = 3-methoxy-4-hydroxyphenylacetate + NADH + H+;1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH;D-glyceraldehyde + NAD+ + H2O = D-glycerate + NADH + H+;Imidazole-4-acetaldehyde + NAD+ + H2O <=> Imidazole-4-acetate + NADH + H+;2-Propynal + NAD+ + H2O <=> Propynoate + NADH + H+;D-Glucuronolactone + NAD+ + 2 H2O <=> D-Glucarate + NADH + H+;p-carboxybenzaldehyde + NAD+ + H2O = p-carboxybenzoate + NADH;Aldehyde + NAD+ + H2O <=> Fatty acid + NADH + H+;(S)-Methylmalonate semialdehyde + NAD+ + H2O <=> Methylmalonate + NADH + H+;3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al + NAD+ + H2O <=> 3alpha,7alpha-Dihydroxy-5beta-cholestanate + NADH + H+;trans-3-Chloroallyl aldehyde + H2O <=> trans-3-Chloroacrylic acid + 2 H+;cis-3-Chloroallyl aldehyde + H2O <=> cis-3-Chloroacrylic acid + 2 H+;(2E)-hexadecenal + NAD+ + H2O = (2E)-hexadecenoate + NADH + H+;hydroxypyruvaldehyde phosphate + H2O + NAD+ = 3-phospho-hydroxypyruvate + NADH + H+;3-dimethylsulfoniopropionaldehyde + H2O + NAD+ = dimethylsulfoniopropanoate + NADH + H+;2-methyl branched 2,3,4-saturated fatty aldehyde + NAD+ + H2O = 2-methyl branched 2,3,4-saturated fatty acid + NADH + H+;odd numbered straight chain 2,3,4-saturated fatty aldehyde + NAD+ + H2O = odd numbered straight chain 2,3,4-saturated fatty acid + NADH + H+;retinol + NAD+ + H2O = retinoic acid + NADH + H+" "an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH;a carboxylate + 2 H(+) + NADH => an aldehyde + H2O + NAD(+);acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH;acetate + 2 H(+) + NADH => acetaldehyde + H2O + NAD(+)" "succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+;4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + H+;(S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+;2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+;an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+;4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH + 2 H+;4-guanidinobutanal + NAD+ + H2O = 4-guanidinobutanoate + NADH + H+;salicylaldehyde + NAD+ + H2O = salicylate + NADH + 2 H+;benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+;Aldehyde + NAD+ + H2O <=> Carboxylate + NADH + H+;glycolaldehyde + NAD+ + H2O = glycolate + NADH + H+;retinal + NAD+ + H2O = retinoate + NADH + H+;phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+;a long-chain aldehyde + NAD+ + H2O = a long-chain carboxylate + NADH + H+;betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+;(2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+;geranial + H2O + NAD+ = geranate + NADH + H+;D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + 2 H+;3-aminopropanal + NAD+ + H2O = 3-aminopropanoate + NADH + H+;propionaldehyde + NAD+ + H2O = propionate + NADH + H+;acetaldehyde + NAD+ + H2O = acetate + NADH + H+;2-oxoglutaric semialdehyde + NAD+ + H2O = 2-oxoglutarate + NADH;D-lactaldehyde + NAD+ + H2O = D-lactate + NADH + H+;p-nitrobenzaldehyde + NAD+ + H2O = p-nitrobenzoate + NADH;octanal + NAD+ + H2O = octanoate + NADH + H+;decanal + NAD+ + H2O = decanoate + NADH;dodecanal + NAD+ + H2O = dodecanoate + NADH;monochloroacetaldehyde + NAD+ + H2O = monochloroacetate + NADH;3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O = 3,4-dihydroxyphenylacetate + NADH + H+;N-acetyl-4-aminobutyraldehyde + NAD+ + H2O = N-acetyl-4-aminobutyrate + NADH;p-methylbenzaldehyde + NAD+ + H2O = p-methylbenzoate + NADH;m-methylbenzaldehyde + NAD+ + H2O = m-methylbenzoate + NADH;indole-3-acetaldehyde + NAD+ + H2O = indole-3-acetate + NADH + H+;3,4-dihydroxymandelic aldehyde + NAD+ + H2O = 3,4-dihydroxymandelate + NADH;5-hydroxyindol acetaldehyde + NAD+ + H2O = 5-hydroxyindol acetate + NADH;acetaldehyde + NADP+ + H2O = acetate + NADPH + H+;propanal + beta-NADP+ + H2O = propionate + beta-NADPH + H+;perillaldehyde + NAD+ + H2O = perillic acid + NADH;octadecanal + NAD+ + H2O = octadecanoic acid + NADH;(S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+;phytenal + NAD+ + H2O = phytenate + NADH + H+;4-aminobutyraldehyde + NADP+ + H2O = 4-aminobutanoate + NADPH;syringaldehyde + NAD+ + H2O = syringic acid + NADH;3-hydroxypropionaldehyde + NAD+ + H2O = 3-hydroxypropanoate + NADH + 2 H+;glyceryl trinitrate + NADH + H+ = 1,3-glyceryl dinitrate + nitrite + NAD+;phosphonoacetaldehyde + NAD+ + H2O = phosphonoacetate + NADH + H+;formaldehyde + NAD+ + H2O = formate + NADH + H+;3-hydroxybenzaldehyde + NAD+ + H2O = 3-hydroxybenzoate + NADH + H+;4-hydroxyphenyl-3-methoxyglycolaldehyde + NAD+ + H2O = 4-hydroxyphenyl-3-methoxyglycolate + NADH;2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH;3-methoxy-4-hydroxyphenylacetaldehyde + NAD+ + H2O = 3-methoxy-4-hydroxyphenylacetate + NADH + H+;1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH;D-glyceraldehyde + NAD+ + H2O = D-glycerate + NADH + H+;Imidazole-4-acetaldehyde + NAD+ + H2O <=> Imidazole-4-acetate + NADH + H+;2-Propynal + NAD+ + H2O <=> Propynoate + NADH + H+;D-Glucuronolactone + NAD+ + 2 H2O <=> D-Glucarate + NADH + H+;p-carboxybenzaldehyde + NAD+ + H2O = p-carboxybenzoate + NADH;Aldehyde + NAD+ + H2O <=> Fatty acid + NADH + H+;(S)-Methylmalonate semialdehyde + NAD+ + H2O <=> Methylmalonate + NADH + H+;3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al + NAD+ + H2O <=> 3alpha,7alpha-Dihydroxy-5beta-cholestanate + NADH + H+;trans-3-Chloroallyl aldehyde + H2O <=> trans-3-Chloroacrylic acid + 2 H+;cis-3-Chloroallyl aldehyde + H2O <=> cis-3-Chloroacrylic acid + 2 H+;(2E)-hexadecenal + NAD+ + H2O = (2E)-hexadecenoate + NADH + H+;hydroxypyruvaldehyde phosphate + H2O + NAD+ = 3-phospho-hydroxypyruvate + NADH + H+;3-dimethylsulfoniopropionaldehyde + H2O + NAD+ = dimethylsulfoniopropanoate + NADH + H+;2-methyl branched 2,3,4-saturated fatty aldehyde + NAD+ + H2O = 2-methyl branched 2,3,4-saturated fatty acid + NADH + H+;odd numbered straight chain 2,3,4-saturated fatty aldehyde + NAD+ + H2O = odd numbered straight chain 2,3,4-saturated fatty acid + NADH + H+;retinol + NAD+ + H2O = retinoic acid + NADH + H+" "2,5-Dioxopentanoate + NADP+ + H2O <=> 2-Oxoglutarate + NADPH + H+;Aldehyde + NAD+ + H2O <=> Fatty acid + NADH + H+;Acetaldehyde + NAD+ + H2O <=> Acetate + NADH + H+;3-Aminopropanal + NAD+ + H2O <=> beta-Alanine + NADH + H+;D-Glyceraldehyde + NAD+ + H2O <=> D-Glycerate + NADH + H+;4-Aminobutyraldehyde + NADP+ + H2O <=> 4-Aminobutanoate + NADPH + H+;4-Aminobutyraldehyde + NAD+ + H2O <=> 4-Aminobutanoate + NADH + H+;Indole-3-acetaldehyde + NAD+ + H2O <=> Indole-3-acetate + NADH + H+;2-Propynal + NAD+ + H2O <=> Propynoate + NADH + H+;D-Glucuronolactone + NAD+ + 2 H2O <=> D-Glucarate + NADH + H+;4-Trimethylammoniobutanal + NAD+ + H2O <=> 4-Trimethylammoniobutanoate + NADH + H+;(S)-Methylmalonate semialdehyde + NAD+ + H2O <=> Methylmalonate + NADH + H+;Imidazole-4-acetaldehyde + NAD+ + H2O <=> Imidazole-4-acetate + NADH + H+;3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al + NAD+ + H2O <=> 3alpha,7alpha-Dihydroxy-5beta-cholestanate + NADH + H+;5-Hydroxyindoleacetaldehyde + NAD+ + H2O <=> 5-Hydroxyindoleacetate + H+ + NADH;N4-Acetylaminobutanal + NAD+ + H2O <=> 4-Acetamidobutanoate + NADH + H+;trans-3-Chloroallyl aldehyde + H2O <=> trans-3-Chloroacrylic acid + 2 H+;cis-3-Chloroallyl aldehyde + H2O <=> cis-3-Chloroacrylic acid + 2 H+;Chloroacetaldehyde + NAD+ + H2O <=> Chloroacetic acid + NADH + H+;Perillyl aldehyde + H2O + NAD+ <=> Perillic acid + NADH + H+;2-trans,6-trans-Farnesal + NAD+ + H2O <=> Farnesoic acid + NADH + H+" "ALDH3A2-2 oxidizes pristanal to pristanate;ALDH3A2-1 oxidises HD2NAL to PALM;ALDH3B1 oxidises HXAL to PALM;Exocytosis of secretory granule membrane proteins;Exocytosis of specific granule membrane proteins;ALDH3B2 oxidises HXAL to PALM" 5 out of 5 An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH. "2,5-Dioxopentanoate + NADP+ + H2O <=> 2-Oxoglutarate + NADPH + H+;Aldehyde + NAD+ + H2O <=> Fatty acid + NADH + H+;Acetaldehyde + NAD+ + H2O <=> Acetate + NADH + H+;3-Aminopropanal + NAD+ + H2O <=> beta-Alanine + NADH + H+;D-Glyceraldehyde + NAD+ + H2O <=> D-Glycerate + NADH + H+;4-Aminobutyraldehyde + NADP+ + H2O <=> 4-Aminobutanoate + NADPH + H+;4-Aminobutyraldehyde + NAD+ + H2O <=> 4-Aminobutanoate + NADH + H+;Indole-3-acetaldehyde + NAD+ + H2O <=> Indole-3-acetate + NADH + H+;2-Propynal + NAD+ + H2O <=> Propynoate + NADH + H+;D-Glucuronolactone + NAD+ + 2 H2O <=> D-Glucarate + NADH + H+;4-Trimethylammoniobutanal + NAD+ + H2O <=> 4-Trimethylammoniobutanoate + NADH + H+;(S)-Methylmalonate semialdehyde + NAD+ + H2O <=> Methylmalonate + NADH + H+;Imidazole-4-acetaldehyde + NAD+ + H2O <=> Imidazole-4-acetate + NADH + H+;3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al + NAD+ + H2O <=> 3alpha,7alpha-Dihydroxy-5beta-cholestanate + NADH + H+;5-Hydroxyindoleacetaldehyde + NAD+ + H2O <=> 5-Hydroxyindoleacetate + H+ + NADH;N4-Acetylaminobutanal + NAD+ + H2O <=> 4-Acetamidobutanoate + NADH + H+;trans-3-Chloroallyl aldehyde + H2O <=> trans-3-Chloroacrylic acid + 2 H+;cis-3-Chloroallyl aldehyde + H2O <=> cis-3-Chloroacrylic acid + 2 H+;Chloroacetaldehyde + NAD+ + H2O <=> Chloroacetic acid + NADH + H+;Perillyl aldehyde + H2O + NAD+ <=> Perillic acid + NADH + H+;2-trans,6-trans-Farnesal + NAD+ + H2O <=> Farnesoic acid + NADH + H+" YES Sphingolipid metabolism "pathway from reactome; it is changed into Sphingolipid metabolism. Subsystem may be wrong according to kegg database" "E74;E595;H86;H970" "Glycolysis / Gluconeogenesis;Fatty acid degradation;Valine, leucine and isoleucine degradation;Lysine degradation;Arginine and proline metabolism;Histidine metabolism;Tryptophan metabolism;beta-Alanine metabolism;Glycerolipid metabolism;Pyruvate metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics" "Sphingolipid de novo biosynthesis;Phase I - Functionalization of compounds;Alpha-oxidation of phytanate;Neutrophil degranulation" "Glycolysis / Gluconeogenesis;path:map00010;Ascorbate and aldarate metabolism;path:map00053;Fatty acid degradation;path:map00071;Valine, leucine and isoleucine degradation;path:map00280;Lysine degradation;path:map00310;Arginine and proline metabolism;path:map00330;Histidine metabolism;path:map00340;Tryptophan metabolism;path:map00380;beta-Alanine metabolism;path:map00410;Glycerolipid metabolism;path:map00561;Pyruvate metabolism;path:map00620;Chloroalkane and chloroalkene degradation;path:map00625;Limonene and pinene degradation;path:map00903;Insect hormone biosynthesis;path:map00981;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" "mitochondrial membrane;cytoplasm" "mitochondrion;mitochondrial membrane;cytoplasm;endoplasmic reticulum;lipid particle" "mitochondrial membrane;cytoplasm" +653 YMR149W "Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum" 2.4.99.18 Delta subunit of the oligosaccharyl transferase glycoprotein complex Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1 (Oligosaccharyl transferase subunit SWP1) (EC 2.4.99.18) (Oligosaccharyl transferase subunit delta) "SWP1; dolichyl-diphosphooligosaccharide-protein glycotransferase" NA "oligosaccharyl transferase complex δ subunit" NA "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA NA 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps NA "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +655 YMR162C "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" "ATP + H2O = ADP + phosphate;acetyl phosphate + H2O = acetate + phosphate;phospholipid + ATP + H2O = phospholipid + ADP + phosphate + H+;ATP + H2O + phosphoethanolamine/in = ADP + phosphate + phosphoethanolamine/out;ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2];ATP + H2O + phosphatidylserine/out = ADP + phosphate + phosphatidylserine/in;ATP + H2O + phosphatidylethanolamine/out = ADP + phosphate + phosphatidylethanolamine/in;ATP + H2O + miltefosine/in = ADP + phosphate + miltefosine/out;ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out" 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). phospholipid + ATP + H2O <=> phospholipid + ADP + phosphate + H+ YES phospholipids transport "transport of phospholipids (Probable); reaction not sure" "E586;H449" NA Golgi "Golgi membrane;endoplasmic reticulum;Golgi" Golgi +658 YMR210W "Monoacylglycerol lipase; palmitoyl monoacylglycerol is the preferred substrate; role in triacylglycerol catabolism; minor role in medium-chain fatty acid ethyl ester biosynthesis; contains an alpha/beta hydrolase domain and a typical lipase motif; has similarity to acyltransferases, Eeb1p and Eht1p, and human ABHD1" 3.1.1.- Monoacylglycerol lipase NA 3.1.1.- Putative esterase YMR210W (EC 3.1.1.-) "MGL2; putative carboxylic ester hydrolase" NA monoacylglycerol lipase ABHD3 hydrolyses LPC(14:0) to 1AGPC NA NA NA NA "1-oleoyl-sn-glycerol + H2O => glycerol + oleate + H+;a 1-monoglyceride + H2O => a fatty acid + glycerol + H+" NA ABHD3 hydrolyses LPC(14:0) to 1AGPC 3 out of 5 NA "1-oleoyl-sn-glycerol + H2O => glycerol + oleate + H+;a 1-monoglyceride + H2O => a fatty acid + glycerol + H+" YES Glycerophospholipid metabolism pathway from biocyc and reactome E371 NA NA NA monoacylglycerol metabolism // triacylglycerol degradation Synthesis of PC NA +666 YMR243C "Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication" Vacuolar membrane zinc transporter Probably responsible for the uptake of zinc and cadmium ions. Zinc/cadmium resistance protein "ZRC1, OSR1; Zn(2+) transporter ZRC1" Zinc Resistance Conferring "ZnT1 mediates the efflux of zinc from the cell;SLC30A8 transports Zn2+ from cytosol to secretory granule;SLC30A10 transports Mn2+ from cytosol to extracellular region" ZnT1 mediates the efflux of zinc from the cell 4 out of 5 NA Zn2+ <=> Zn2+ YES zinc transport Vacuolar membrane zinc transporter "Insulin processing;Metal ion SLC transporters;Zinc efflux and compartmentalization by the SLC30 family" NA mitochondrial membrane "vacuole;mitochondrion;mitochondrial membrane" mitochondrial membrane +668 YMR251W "Omega class glutathione transferase; putative cytosolic localization" 2.5.1.18 Omega class glutathione transferase Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). {ECO:0000269|PubMed:16709151}. 2.5.1.18 Glutathione S-transferase omega-like 3 (EC 2.5.1.18) "GTO3; omega-class glutathione transferase" NA Glutathione Transferase Omega-like NA "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" "glutathione + RX => a halide anion + an S-substituted glutathione + H(+);a halide anion + an S-substituted glutathione + H(+) => glutathione + RX;1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+);2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione" "5-Androstene-3,17-dione = 4-Androstene-3,17-dione;glutathione + 1-chloro-2,4-dinitrobenzene = S-2,4-dinitrophenylglutathione + HCl;rac-4-hydroxynonenal + glutathione = S-(4-hydroxy-1-oxononan-3-yl)glutathione;RX + glutathione = HX + R-S-glutathione;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Nitrile + Glutathione <=> Hydrogen cyanide + R-S-Glutathione;Sulfuric monoester + Glutathione <=> Sulfate + R-S-Glutathione;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH;glutathione + RX = glutathione-toxin conjugate + HX;3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione = 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + H2O;RX + glutathione = HX + R-S-G;harderoporphyrinogen + glutathione = harderoporphyrinogen-S-glutathione + H2O;glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid = chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid;12-oxo-phytodienoic acid + glutathione = 10-S-glutathionyl-12-oxo-phytodienoic acid + H2O;protoporphyrinogen + glutathione = protoporphyrinogen-S-glutathione + H2O;brostallicin + glutathione = glutathionyl-brostallicin" NA NA NA 3 out of 5 RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:16709151}. RX + glutathione = HX + R-S-glutathione YES Glutathione metabolism "pathway from kegg; reaction from uniprot" "H675;H1101" NA NA NA NA NA "Glutathione metabolism;path:map00480;Metabolism of xenobiotics by cytochrome P450;path:map00980;Drug metabolism - cytochrome P450;path:map00982" cytoplasm cytoplasm cytoplasm +669 YMR274C "Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone" 3.4.22.- Type II CAAX prenyl protease Proteolytically removes the C-terminal three residues of farnesylated proteins, including the a-factor mating pheromone and RAS. {ECO:0000269|PubMed:10825201, ECO:0000269|PubMed:9065405}. 3.4.22.- CAAX prenyl protease 2 (EC 3.4.22.-) (Prenyl protein-specific endoprotease 2) (PPSEP 2) (Ras and A-factor-converting enzyme) (RACE) "RCE1; CAAX prenyl protease" NA Ras and a-factor Converting Enzyme "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1;USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1" NA NA NA NA NA S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide NA 4 out of 5 NA S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide YES Terpenoid backbone biosynthesis pathway from kegg H1123 NA NA "Terpenoid backbone biosynthesis;Biosynthesis of antibiotics" NA Ub-specific processing proteases NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +676 YMR301C "Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; human homolog ABCB7 can complement yeast null mutant" Mitochondrial inner membrane ATP-binding cassette (ABC) transporter Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound. {ECO:0000269|PubMed:10406803, ECO:0000269|PubMed:24604199}. Iron-sulfur clusters transporter ATM1, mitochondrial "ATM1; ATP-binding cassette Fe/S cluster precursor transporter ATM1" ABC Transporter, Mitochondrial "ABCB6 transports porphyrin from cytosol to mitchondrial matrix;4Fe-4S cluster assembles on CFD1:NBP35 scaffold;ABC7, mABC1 and mABC2 mediate heme transport" "ABCB6 transports porphyrin from cytosol to mitchondrial matrix;ABC7, mABC1 and mABC2 mediate heme transport" 5 out of 5 NA porphyrin <=> porphyrin YES porphyrin transport "exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; is porphyrin the precursors of iron-sulfur (Fe/S) clusters ??? porphyrin[c] + ATP + H2O <=> porphyrin[m] + ADP + phosphate + H(+)" ABC transporters "Mitochondrial ABC transporters;Cytosolic iron-sulfur cluster assembly (yeast)" NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +678 YMR306W "Protein involved in spore wall assembly; has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" 2.4.1.34 Protein involved in spore wall assembly Required for spore wall assembly. {ECO:0000269|PubMed:17158736}. 2.4.1.34 1,3-beta-glucan synthase component FKS3 (EC 2.4.1.34) (1,3-beta-D-glucan-UDP glucosyltransferase) (FK506 sensitivity protein 3) "FKS3; putative 1,3-beta-D-glucan synthase" 2.4.1.34 FKS3 "[(1->3)-beta-D-glucosyl]n + UDP-alpha-D-glucose => [(1->3)-beta-D-glucosyl]n+1 + H(+) + UDP;[(1->3)-beta-D-glucosyl]n+1 + H(+) + UDP => [(1->3)-beta-D-glucosyl]n + UDP-alpha-D-glucose" UDP-alpha-D-glucose + [(1->3)-beta-D-glucosyl]n = UDP + [(1->3)-beta-D-glucosyl]n+1 "[(1->3)-beta-D-glucosyl]n + UDP-alpha-D-glucose => [(1->3)-beta-D-glucosyl]n+1 + H(+) + UDP;[(1->3)-beta-D-glucosyl]n+1 + H(+) + UDP => [(1->3)-beta-D-glucosyl]n + UDP-alpha-D-glucose" UDP-alpha-D-glucose + [(1->3)-beta-D-glucosyl]n = UDP + [(1->3)-beta-D-glucosyl]n+1 UDP-alpha-D-glucose + 1,3-beta-D-glucan(n) => 1,3-beta-D-glucan(n+1) + UDP UDP-glucose + 1,3-beta-D-Glucan <=> UDP + 1,3-beta-D-Glucan 4 out of 5 UDP-glucose + ((1->3)-beta-D-glucosyl)(n) = UDP + ((1->3)-beta-D-glucosyl)(n+1). UDP-glucose + ((1=>3)-beta-D-glucosyl)(n) = UDP + ((1=>3)-beta-D-glucosyl)(n+1) YES Starch and sucrose metabolism pathway from kegg "Starch and sucrose metabolism;MAPK signaling pathway - yeast" "1,3-β-D-glucan biosynthesis" "Starch and sucrose metabolism;path:map00500" mitochondrion "mitochondrion;endoplasmic reticulum" mitochondrion +680 YMR322C "Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation" 4.2.1.130 Possible chaperone and cysteine protease Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893). {ECO:0000250|UniProtKB:Q04432, ECO:0000269|PubMed:24706893}. 4.2.1.130 Probable glutathione-independent glyoxalase SNO4 (EC 4.2.1.130) (Glyoxalase 3 homolog 4) (Heat shock protein 34) (SNZ proximal open reading frame 4) "SNO4, HSP34; glutathione-independent methylglyoxalase family protein" SNZ proximal Open reading frame "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O 4 out of 5 (R)-lactate = methylglyoxal + H(2)O. {ECO:0000250|UniProtKB:Q04432}. (R)-lactate <=> methylglyoxal + H2O YES Methylglyoxal Metabolism pathway from e.coli model E513 "Pyruvate metabolism;path:map00620;Microbial metabolism in diverse environments;path:map01120" cytoplasm cytoplasm cytoplasm +681 YMR323W "Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose" 4.2.1.11 Enolase, a phosphopyruvate hydratase 4.2.1.11 Enolase-related protein 3 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) "ERR3; phosphopyruvate hydratase ERR3" 4.2.1.11 phophopyruvate hydratase "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O 3 out of 5 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O. 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O YES Glycolysis / Gluconeogenesis pathway from kegg "E61;H213" "PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5." "Glycolysis / Gluconeogenesis;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids;RNA degradation" gluconeogenesis // glycolysis // glycolysis III (from glucose) "Glycolysis / Gluconeogenesis;path:map00010;Methane metabolism;path:map00680;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" cytoplasm +687 YNL036W "Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress" 4.2.1.1 Carbonic anhydrase Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase. Involved in protection against oxidative damage. Encodes a substrate for the non-classical protein export pathway for proteins that lack a cleavable signal sequence. {ECO:0000269|PubMed:10407265, ECO:0000269|PubMed:15096093, ECO:0000269|PubMed:15813743, ECO:0000269|PubMed:15948716, ECO:0000269|PubMed:18993072}. 4.2.1.1 Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) (Non-classical export protein 3) "NCE103, NCE3; carbonate dehydratase NCE103" 4.2.1.1 NonClassical Export "H(+) + hydrogencarbonate => CO2 + H2O;CO2 + H2O => H(+) + hydrogencarbonate" H2CO3 = CO2 + H2O "H(+) + hydrogencarbonate => CO2 + H2O;CO2 + H2O => H(+) + hydrogencarbonate" H2CO3 = CO2 + H2O "Carbonic acid <=> CO2 + H2O;HCO3- + H+ <=> CO2 + H2O" 5 out of 5 H(2)CO(3) = CO(2) + H(2)O. {ECO:0000269|PubMed:15813743, ECO:0000269|PubMed:18993072}. HCO3- + H+ <=> CO2 + H2O YES other no pathway from database "E22;H325;H1060" Nitrogen metabolism "Nitrogen metabolism;path:map00910" "cytoplasm;nucleus;mitochondrial membrane" "nucleus;cytoplasm;mitochondrion;mitochondrial membrane" "nucleus;mitochondrial membrane;cytoplasm" +688 YNL038W "Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol" 2.4.1.198 Protein involved in the synthesis of GlcNAc-PI Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. {ECO:0000269|PubMed:11746600}. 2.4.1.198 Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15 (GPI-GlcNAc transferase complex subunit GPI5) (GPI-GnT subunit GPI5) (EC 2.4.1.198) (PIGH homolog) "GPI15; phosphatidylinositol N-acetylglucosaminyltransferase GPI15" GlycosylPhosphatidylInositol anchor biosynthesis "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" an L-1-phosphatidyl-inositol + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H+ UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 3 out of 5 UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol. UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H479;H1129" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;path:map00563;Metabolic pathways;path:map01100" None +690 YNL048W "Alpha-1,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER" 2.4.1.131 Alpha-1,2-mannosyltransferase Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. {ECO:0000269|PubMed:11278778, ECO:0000269|PubMed:16878994, ECO:0000269|PubMed:19929855}. 2.4.1.131 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131) (Alpha-1,2-mannosyltransferase ALG11) (Asparagine-linked glycosylation protein 11) (Glycolipid 2-alpha-mannosyltransferase) "ALG11; alpha-1,2-mannosyltransferase ALG11" 2.4.1.131 "DP-Man:Man3GlcNAc2-PP-dolichol α-1,2-mannosyltransferase" Addition of the fourth and fifth mannose to the N-glycan precursor skeleton by Alg11 "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose" "alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP;alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP;GDP-alpha-D-mannose + alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+;2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol;more = more" "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose" "alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP;alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol + GDP;GDP-alpha-D-mannose + alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+;2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol;more = more" alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+ "G00005 + GDP-D-mannose <=> G10526 + GDP;G10526 + GDP-D-mannose <=> G00006 + GDP" 5 out of 5 2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994, ECO:0000269|PubMed:19929855}. "G00005 + GDP-D-mannose <=> G10526 + GDP;G10526 + GDP-D-mannose <=> G00006 + GDP" YES N-Glycan biosynthesis pathway from kegg "H246;H1138" lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +696 YNL092W "S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene" 2.1.1.22 S-adenosylmethionine-dependent protein methyltransferase N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). {ECO:0000269|PubMed:26001783}. 2.1.1.22 Carnosine N-methyltransferase (EC 2.1.1.22) S-adenosylmethionine-dependent methyltransferase 2.1.1.22 YNL092W CARNMT1 methylates CARN to Anserine "S-adenosyl-L-methionine + carnosine => S-adenosyl-L-homocysteine + anserine + H(+);S-adenosyl-L-homocysteine + anserine + H(+) => S-adenosyl-L-methionine + carnosine" "S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine;actin peptide H + S-adenosyl-L-methionine = actin peptide H methylated at N1-position of histidine + S-adenosyl-L-homocysteine" "S-adenosyl-L-methionine + carnosine => S-adenosyl-L-homocysteine + anserine + H(+);S-adenosyl-L-homocysteine + anserine + H(+) => S-adenosyl-L-methionine + carnosine" "S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine;actin peptide H + S-adenosyl-L-methionine = actin peptide H methylated at N1-position of histidine + S-adenosyl-L-homocysteine" S-Adenosyl-L-methionine + Carnosine <=> S-Adenosyl-L-homocysteine + beta-Alanyl-N(pi)-methyl-L-histidine CARNMT1 methylates CARN to Anserine 4 out of 5 S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine. {ECO:0000269|PubMed:26001783}. S-adenosyl-L-methionine + carnosine <=> S-adenosyl-L-homocysteine + anserine YES Histidine metabolism pathway from kegg Histidine metabolism Histidine catabolism "Histidine metabolism;path:map00340" +697 YNL094W "Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway" 3.1.3.4 Phosphatidate phosphatase, converts phosphatidate to diacylglycerol Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. May play a role in vesicular trafficking through its PAP activity at cortical actin patches. {ECO:0000269|PubMed:23071111}. 3.1.3.4 Phosphatidate phosphatase APP1 (PAP) (EC 3.1.3.4) (Actin patch protein 1) "APP1; phosphatidate phosphatase APP1" Actin Patch Protein "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate;a 1,2-diacyl-sn-glycerol + phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + H2O;1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-2-acyl-sn-glycerol + phosphate;1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O" "a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate;sphingosine 1-phosphate + H2O = sphingosine + phosphate;dihydro-sphingosine-1-phosphate + H2O = dihydro-sphingosine + phosphate;lysophosphatidate + H2O = monoacylglycerol + phosphate;ceramide 1-phosphate + H2O = ceramide + phosphate;2-Acyl-1-alkyl-sn-glycero-3-phosphate + H2O <=> 1-Alkyl-2-acylglycerol + Orthophosphate;1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + H2O = 1-stearoyl-2-palmitoyl-glycerol + phosphate;1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + H2O = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol + phosphate;2-acyl-1-alkyl-sn-glycerol 3-phosphate + H2O = 2-acyl-1-alkyl-sn-glycerol + phosphate;phosphatidic acid + H2O = 1,2-dioleoyl-sn-glycerol + phosphate" "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate;a 1,2-diacyl-sn-glycerol + phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + H2O;1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-2-acyl-sn-glycerol + phosphate;1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O" "a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate;sphingosine 1-phosphate + H2O = sphingosine + phosphate;dihydro-sphingosine-1-phosphate + H2O = dihydro-sphingosine + phosphate;lysophosphatidate + H2O = monoacylglycerol + phosphate;ceramide 1-phosphate + H2O = ceramide + phosphate;2-Acyl-1-alkyl-sn-glycero-3-phosphate + H2O <=> 1-Alkyl-2-acylglycerol + Orthophosphate;1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + H2O = 1-stearoyl-2-palmitoyl-glycerol + phosphate;1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + H2O = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol + phosphate;2-acyl-1-alkyl-sn-glycerol 3-phosphate + H2O = 2-acyl-1-alkyl-sn-glycerol + phosphate;phosphatidic acid + H2O = 1,2-dioleoyl-sn-glycerol + phosphate" 5 out of 5 A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate. {ECO:0000269|PubMed:23071111}. A 1,2-diacylglycerol 3-phosphate + H2O <=> a 1,2-diacyl-sn-glycerol + phosphate YES "Glycerolipid metabolism;Glycerophospholipid metabolism" pathway from kegg "E688;H488;H791" "Glycerolipid metabolism;path:map00561;Glycerophospholipid metabolism;path:map00564;Ether lipid metabolism;path:map00565;Sphingolipid metabolism;path:map00600;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" cytoplasm cytoplasm cytoplasm +699 YNL102W "Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis" 2.7.7.7 Catalytic subunit of the DNA polymerase I alpha-primase complex Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase. POL1 has a role in promoting telomere replication during interaction with CDC13. {ECO:0000269|PubMed:10898792}. 2.7.7.7 DNA polymerase alpha catalytic subunit A (EC 2.7.7.7) (DNA polymerase I subunit A) (DNA polymerase alpha:primase complex p180 subunit) (DNA polymerase-primase complex p180 subunit) (Pol alpha-primase complex p180 subunit) "POL1, CDC17, CRT5, HPR3; DNA-directed DNA polymerase alpha catalytic subunit POL1" 2.7.7.7 POLymerase "Detection of damage during initiation of DNA synthesis in S-phase;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere;RFC binding displaces Pol Alpha on the C-strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin;RFC binding displaces Pol Alpha;Loading of PCNA - Sliding Clamp Formation;RFC dissociates after sliding clamp formation;Formation of the Flap Intermediate;Recruitment of Dna2 endonuclease;Removal of remaining Flap" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA synthesis H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication" "Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus "nucleus;mitochondrion" nucleus +702 YNL113W "RNA polymerase subunit AC19; common to RNA polymerases I and III" RNA polymerase subunit AC19 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerases I and III 16 kDa polypeptide) (RPA19) "RPC19; DNA-directed RNA polymerase core subunit RPC19" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;Binding of RRN3 to RNA Polymerase I" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation NA nucleus nucleus nucleus +708 YNL151C RNA polymerase III subunit C31 RNA polymerase III subunit C31 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. C31 is involved in the formation of the initiation complex. DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III 31 kDa polypeptide) (C31) "RPC31, ACP2, RPC8; DNA-directed RNA polymerase III subunit C31" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus +713 YNL191W "Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" Component of glutamine amidotransferase (GATase II) Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. {ECO:0000269|PubMed:17179087}. Probable glutamine amidotransferase DUG3 (Deficient in utilization of glutathione protein 3) (GSH degradosomal complex subunit DUG3) "DUG3; glutamine amidotransferase subunit DUG3" glutamine amidotransferase II glutathione + H2O => L-cysteinyl-glycine + L-glutamate 5 out of 5 NA glutathione + H2O => L-cysteinyl-glycine + L-glutamate YES Glutathione metabolism "pathway from biocyc;. It is changed into Glutathione metabolism" glutathione degradation (DUG pathway) NA cytoplasm cytoplasm cytoplasm +717 YNL219C "Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of both the seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; human homolog ALG9 can complement yeast null mutant; mutation of human homolog causes type 1 congenital disorders of glycosylation" "2.4.1.259;2.4.1.261" Mannosyltransferase, involved in N-linked glycosylation Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. {ECO:0000269|PubMed:15987956}. "2.4.1.259; 2.4.1.261" Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) "ALG9; dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase" "2.4.1.259;2.4.1.261" Dol-PP-GlcNAc2:Man6:Man transferase "Addition of the seventh mannose to the N-glycan precursor by ALG9;Addition of the last mannose to the N-glycan precursor by ALG9" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate;alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate;Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-a-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate;alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate;Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-a-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+;alpha-D-Man-a-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+" "Dolichyl phosphate D-mannose + G10595 <=> Dolichyl phosphate + G10596;Dolichyl phosphate D-mannose + G10597 <=> Dolichyl phosphate + G00007" 5 out of 5 "Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:15987956}.; Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:15987956}." "Dolichyl phosphate D-mannose + G10595 <=> Dolichyl phosphate + G10596;Dolichyl phosphate D-mannose + G10597 <=> Dolichyl phosphate + G00007" YES N-Glycan biosynthesis pathway from kegg "H1141;NA" lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100;NA" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +720 YNL229C "Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase activity and can mutate to acquire GST activity; self-assembly under limited nitrogen conditions creates [URE3] prion and releases catabolite repression" "1.11.1.9;1.8.4.-" Nitrogen catabolite repression transcriptional regulator Plays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation. Is also an atypical glutaredoxin without a catalytical cysteine residue. Has glutathione peroxidase and thiol:disulfide oxidoreductase activities in both native and fibrillar form. Also shows insulin disulfide reductase and dehydroascorbic acid reductase (DHAR) actvites. {ECO:0000269|PubMed:10604478, ECO:0000269|PubMed:10799523, ECO:0000269|PubMed:15371425, ECO:0000269|PubMed:19321443, ECO:0000269|PubMed:1990286, ECO:0000269|PubMed:8755910}. "1.8.4.-; 1.11.1.9" Transcriptional regulator URE2 (Disulfide reductase) (EC 1.8.4.-) (Glutathione peroxidase) (EC 1.11.1.9) "URE2; Ure2p" 2.5.1.18 glutathione S-transferase "2 glutathione + H2O2 => glutathione disulfide + 2 H2O;glutathione disulfide + 2 H2O => 2 glutathione + H2O2" "2 glutathione + H2O2 = glutathione disulfide + 2 H2O;tert-butyl hydroperoxide + 2 GSH = tert-butyl alcohol + GSSG + H2O;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;2 Glutathione + 5(S)-HPETE <=> Glutathione disulfide + 5(S)-HETE + H2O;2 Glutathione + 15(S)-HPETE <=> Glutathione disulfide + (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + H2O;glutathione + ROOH = glutathione disulfide + ROH + H2O;5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O" "2 glutathione + H2O2 => glutathione disulfide + 2 H2O;glutathione disulfide + 2 H2O => 2 glutathione + H2O2" "2 glutathione + H2O2 = glutathione disulfide + 2 H2O;tert-butyl hydroperoxide + 2 GSH = tert-butyl alcohol + GSSG + H2O;cumene hydroperoxide + 2 GSH = cumene hydroxide + GSSG + H2O;2 Glutathione + 5(S)-HPETE <=> Glutathione disulfide + 5(S)-HETE + H2O;2 Glutathione + 15(S)-HPETE <=> Glutathione disulfide + (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + H2O;glutathione + ROOH = glutathione disulfide + ROH + H2O;5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O" "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+;glutathione + 4-hydroxy-2-nonenal = 4-hydroxy-2-nonenal-glutathione conjugate;glutathione + RX = a glutathione-toxin conjugate + HX" "RX + Glutathione <=> Halide + R-S-Glutathione;(1R,2S)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene;(1S,2R)-Naphthalene 1,2-oxide + Glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene;1-Nitronaphthalene-7,8-oxide + Glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene;1-Nitronaphthalene-5,6-oxide + Glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene;Bromobenzene-3,4-oxide + Glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene;Bromobenzene-2,3-oxide + Glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene;Benzo[a]pyrene-4,5-oxide + Glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene;Benzo[a]pyrene-7,8-diol + Glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O;2,2-Dichloroacetaldehyde + Glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione;1,1-Dichloroethylene epoxide + Glutathione <=> 2-(S-Glutathionyl)acetyl chloride + Hydrochloric acid;Chloroacetyl chloride + Glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric acid;2-(S-Glutathionyl)acetyl chloride + Glutathione <=> 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid;Trichloroethene + Glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid;1,2-Dibromoethane + Glutathione + H+ <=> Glutathione episulfonium ion + 2 Hydrobromic acid;2-Bromoacetaldehyde + Glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic acid;Aldophosphamide + Glutathione <=> 4-Glutathionyl cyclophosphamide + H2O;Aflatoxin B1-exo-8,9-epoxide + Glutathione <=> Aflatoxin B1exo-8,9-epoxide-GSH" 5 out of 5 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O. {ECO:0000269|PubMed:19321443}. 2 glutathione + H2O2 <=> glutathione disulfide + 2 H2O YES Glutathione metabolism pathway from kegg "NA;NA" Glutathione metabolism "NA;NA" cytoplasm cytoplasm cytoplasm +723 YNL248C "RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p" RNA polymerase I subunit A49 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. The heterodimer formed by RPA34 and RPA49 stimulates transcript elongation by Pol I. Subunit RPA49 can bind both single-stranded and double-stranded DNA. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:20797630, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerase I subunit RPA49 (A49) (DNA-directed RNA polymerase I 49 kDa polypeptide) "RPA49; DNA-directed RNA polymerase I subunit RPA49" RNA Polymerase A Binding of RRN3 to RNA Polymerase I a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation NA nucleus nucleus nucleus +724 YNL262W "Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p" 2.7.7.7 Catalytic subunit of DNA polymerase (II) epsilon DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. {ECO:0000269|PubMed:12124389}. 2.7.7.7 DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) "POL2, DUN2; DNA polymerase epsilon catalytic subunit" 2.7.7.7 POLymerase "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;DNA polymerase epsilon binds at the origin" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair" "Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus +725 YNL274C "Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" 1.1.1.26 Glyoxylate reductase Reversibly reduces glyoxylate to glycolate. {ECO:0000269|PubMed:17173333}. 1.1.1.26 Glyoxylate reductase 1 (EC 1.1.1.26) "GOR1; glyoxylate reductase" 1.1.1.26 glyoxylate reductase 1 glyoxylate + NADPH + H+ => glycolate + NADP+ "glycolate + NAD(+) => glyoxylate + H(+) + NADH;glyoxylate + H(+) + NADH => glycolate + NAD(+)" "glycolate + NAD+ = glyoxylate + NADH + H+;D-glycerate + NAD+ = hydroxypyruvate + NADH + H+;glycolate + NADP+ = glyoxylate + NADPH + H+" "glycolate + NAD(+) => glyoxylate + H(+) + NADH;glyoxylate + H(+) + NADH => glycolate + NAD(+)" "glycolate + NAD+ = glyoxylate + NADH + H+;D-glycerate + NAD+ = hydroxypyruvate + NADH + H+;glycolate + NADP+ = glyoxylate + NADPH + H+" glycolate + NAD+ = glyoxylate + NADH + H+ "Glycolate + NAD+ <=> Glyoxylate + NADH + H+;D-Glycerate + NAD+ <=> Hydroxypyruvate + NADH + H+" 5 out of 5 Glycolate + NAD(+) = glyoxylate + NADH. glycolate + NAD+ <=> glyoxylate + NADH + H+ YES Glyoxylate and dicarboxylate metabolism pathway from kegg "E305;E351;E582" "Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Biosynthesis of secondary metabolites" Glyoxylate metabolism and glycine degradation "Glyoxylate and dicarboxylate metabolism;path:map00630;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120" "cytoplasm;nucleus;mitochondrion" "nucleus;cytoplasm;mitochondrion" "mitochondrion;nucleus;cytoplasm" +726 YNL275W "Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1" Boron efflux transporter of the plasma membrane Functions in boric acid/borate export across the plasma membrane, and thereby protects yeast cells from boron toxicity. Involved in the trafficking of proteins to the vacuole. {ECO:0000269|PubMed:11401825, ECO:0000269|PubMed:16565073, ECO:0000269|PubMed:16923078, ECO:0000269|PubMed:17166224, ECO:0000269|PubMed:17459946}. Boron transporter 1 "BOR1; Bor1p" BORon transporter "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-;Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;Na+-driven Cl-/HCO3- exchanger transport;Na+-driven Cl-/HCO3- exchanger transport;SLC4A4 cotransports Na+ with 3HCO3-" "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-;Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A1,2,3 exchanges HCO3- for Cl-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;SLC4A5,7,9 cotransport Na+ with 3HCO3-;Na+-driven Cl-/HCO3- exchanger transport;Na+-driven Cl-/HCO3- exchanger transport;SLC4A4 cotransports Na+ with 3HCO3-" 4 out of 5 NA Br- <=> Br- YES Boron transport Boron efflux transporter of the plasma membrane "Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Bicarbonate transporters" NA "cell envelope;vacuolar membrane" "vacuole;vacuolar membrane;cell envelope" "cell envelope;vacuolar membrane" +729 YNL315C "Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo" Molecular chaperone Essential for the assembly of the mitochondrial F1-F0 complex. May interact with the alpha and/or beta subunits of F1-ATPase. Protein ATP11, mitochondrial "ATP11; Atp11p" ATP synthase ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] 3 out of 5 NA ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] YES Oxidative phosphorylation pathway from kegg superpathway of purine nucleotides de novo biosynthesis I // adenosine nucleotides de novo biosynthesis // adenosine ribonucleotides de novo biosynthesis NA mitochondrion mitochondrion mitochondrion +732 YNL331C "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" Putative aryl-alcohol dehydrogenase 1.1.1.- Putative aryl-alcohol dehydrogenase AAD14 (EC 1.1.1.-) "AAD14; putative aryl-alcohol dehydrogenase" aryl-alcohol dehydrogenase "3-chlorobenzyl alcohol + NAD+ = 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ = 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ = 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ = p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ = 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ = an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ = benzaldehyde + NADH + H+" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism "pathway from E.coli model; reaction from biocyc" "E646;E743;H1286" NA +733 YNL332W "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" Protein involved in synthesis of the thiamine precursor HMP Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. {ECO:0000250|UniProtKB:P43534}. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI12 (HMP-P synthase) (Hydroxymethylpyrimidine phosphate synthase) (Thiamine biosynthesis protein 12) (Thiamine pyrimidine synthase) "THI12; 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" MONOMER3O-9140 [an HMP-P synthase]-L-histidine + pyridoxal 5'-phosphate => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + an HMP-P synthase Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine 3 out of 5 NA Pyridoxal phosphate + L-Histidine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine YES Thiamine metabolism pathway from kegg thiamine biosynthesis "PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000305|PubMed:12777485}." "Thiamine metabolism;Metabolic pathways" superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis NA +734 YNL333W "Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p" 4.3.3.6 Member of a stationary phase-induced gene family Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. {ECO:0000250|UniProtKB:Q03148}. 4.3.3.6 Probable pyridoxal 5'-phosphate synthase subunit SNZ2 (PLP synthase subunit SNZ2) (EC 4.3.3.6) (PDX1 homolog 2) (Pdx1.2) "SNZ2; pyridoxine biosynthesis protein SNZ2" 4.3.3.6 SNooZe "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O 3 out of 5 D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate. {ECO:0000250|UniProtKB:Q03148}. D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O YES Vitamin B6 metabolism pathway from kegg "PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis." Vitamin B6 metabolism "Vitamin B6 metabolism;path:map00750" +735 YNL334C "Protein of unknown function; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin" "3.5.1.2;4.3.3.6" Protein of unknown function Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform. {ECO:0000250|UniProtKB:Q03144, ECO:0000269|PubMed:12271461}. "4.3.3.6; 3.5.1.2" Probable pyridoxal 5'-phosphate synthase subunit SNO2 (EC 4.3.3.6) (PDX2 homolog 2) (Pdx2.2) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) "SNO2; putative pyridoxal 5'-phosphate synthase" 4.3.3.6 SNZ proximal Open reading frame "L-glutamine + H2O => L-glutamate + NH4(+);L-glutamate + NH4(+) => L-glutamine + H2O;aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine" "L-glutamine + H2O = L-glutamate + NH3;D-glutamine + H2O = D-glutamate + NH3;a monocarboxylic acid amide + H2O = a monocarboxylate + NH3;L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+" "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate;L-glutamate + 3 H2O + H(+) + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine;L-glutamine + H2O => L-glutamate + NH4(+);L-glutamate + NH4(+) => L-glutamine + H2O" "L-glutamine + H2O = L-glutamate + NH3;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate;D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate;D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O;keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + H2O + H+;L-glutamine + H2O = L-glutamate + NH3;D-glutamine + H2O = D-glutamate + NH3;a monocarboxylic acid amide + H2O = a monocarboxylate + NH3" D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O 4 out of 5 "D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate. {ECO:0000250|UniProtKB:Q03144}.; L-glutamine + H(2)O = L-glutamate + NH(3). {ECO:0000250|UniProtKB:Q03144}." "D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate + Orthophosphate + 3 H2O; L-glutamine + H(2)O = L-glutamate + NH(3)" YES Vitamin B6 metabolism pathway from kegg "NA;NA" "PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. {ECO:0000250|UniProtKB:Q03144}." Vitamin B6 metabolism "Vitamin B6 metabolism;path:map00750;NA" cytoplasm +736 YNL335W "Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI2 and Ddi2p" 4.2.1.69 Cyanamide hydratase that detoxifies cyanamide Cyanamide hydratase involved in the detoxification and/or utilization of cyanamide, a toxic nitrile compound distributed widely in the environment. {ECO:0000269|PubMed:25847245}. 4.2.1.69 Cyanamide hydratase DDI3 (CAH) (EC 4.2.1.69) (DNA damage-inducible protein 3) "DDI3; cyanamide hydratase" 4.2.1.69 DNA Damage Inducible "urea => cyanamide + H2O;cyanamide + H2O => urea" urea = cyanamide + H2O "urea => cyanamide + H2O;cyanamide + H2O => urea" urea = cyanamide + H2O Urea <=> Cyanamide + H2O 4 out of 5 Urea = cyanamide + H(2)O. {ECO:0000269|PubMed:25847245}. Urea <=> Cyanamide + H2O YES Atrazine degradation pathway from kegg Atrazine degradation "Atrazine degradation;path:map00791;Microbial metabolism in diverse environments;path:map01120" +738 YNR003C "RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex" RNA polymerase III subunit C34 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in recruitment of Pol III to the preinitiation complex. Involved in the configuration of an initiation-competent form of RNA polymerase. {ECO:0000269|PubMed:9312031}. DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (C34) (DNA-directed RNA polymerase III 36 kDa polypeptide) "RPC34; DNA-directed RNA polymerase III subunit C34" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus "nucleus;cytoplasm;mitochondrion" nucleus +741 YNR027W "Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)" 2.7.1.35 Putative pyridoxal kinase Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (By similarity). Important for bud site selection. {ECO:0000250, ECO:0000269|PubMed:11452010}. 2.7.1.35 Putative pyridoxal kinase BUD17 (EC 2.7.1.35) (Bud site selection protein 17) "BUD17; putative pyridoxal kinase BUD17" 2.7.1.35 BUD site selection "Exocytosis of secretory granule lumen proteins;Exocytosis of secretory granule lumen proteins;Exocytosis of specific granule lumen proteins;Exocytosis of specific granule lumen proteins;2xPDXK:2xZn2+ phosphorylates PXA;2xPDKX:2xZn2+ phosphorylates PDX;2xPDXK:2xZn2+ phosphorylates PXL" "ATP + pyridoxal => ADP + H(+) + pyridoxal 5'-phosphate;ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal;ATP + pyridoxamine => ADP + H(+) + pyridoxamine 5'-phosphate;ADP + H(+) + pyridoxamine 5'-phosphate => ATP + pyridoxamine;ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate;ADP + H(+) + pyridoxine 5'-phosphate => ATP + pyridoxine" "ATP + pyridoxine = ADP + pyridoxine 5'-phosphate;ATP + pyridoxamine = ADP + pyridoxamine 5'-phosphate;ATP + pyridoxal = ADP + pyridoxal 5'-phosphate" "ATP + pyridoxal => ADP + H(+) + pyridoxal 5'-phosphate;ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal;ATP + pyridoxamine => ADP + H(+) + pyridoxamine 5'-phosphate;ADP + H(+) + pyridoxamine 5'-phosphate => ATP + pyridoxamine;ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate;ADP + H(+) + pyridoxine 5'-phosphate => ATP + pyridoxine" "ATP + pyridoxine = ADP + pyridoxine 5'-phosphate;ATP + pyridoxamine = ADP + pyridoxamine 5'-phosphate;ATP + pyridoxal = ADP + pyridoxal 5'-phosphate" "ATP + Pyridoxal <=> ADP + Pyridoxal phosphate;ATP + Pyridoxine <=> ADP + Pyridoxine phosphate;ATP + Pyridoxamine <=> ADP + Pyridoxamine phosphate" "2xPDXK:2xZn2+ phosphorylates PXA;2xPDKX:2xZn2+ phosphorylates PDX;2xPDXK:2xZn2+ phosphorylates PXL" 4 out of 5 ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. ATP + pyridoxal <=> ADP + pyridoxal 5'-phosphate YES Vitamin B6 metabolism pathway from kegg E125 "Vitamin B6 metabolism;Metabolic pathways" "Neutrophil degranulation;Vitamins B6 activation to pyridoxal phosphate" "Vitamin B6 metabolism;path:map00750;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +743 YNR030W "Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant" 2.4.1.260 Alpha-1,6-mannosyltransferase localized to the ER Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. {ECO:0000269|PubMed:10336995, ECO:0000269|PubMed:15987956}. 2.4.1.260 Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Extracellular mutant protein 39) (Mannosyltransferase ALG12) "ALG12, ECM39; dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase" 2.4.1.260 "dolichyl-P-Man:Man7GlcNAc2-PP-dolichol α-1,6-mannosyltransferase" Addition of the eighth mannose to the N-glycan precursor by ALG12 "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-a-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate" "Dolichyl phosphate D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-a-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-mannosyl phosphate => alpha-D-Man-a-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+ Dolichyl phosphate D-mannose + G10596 <=> Dolichyl phosphate + G10597 4 out of 5 Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:15987956}. Dolichyl phosphate D-mannose + G10596 <=> Dolichyl phosphate + G10597 YES N-Glycan biosynthesis pathway from kegg H1142 lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +751 YNR060W "Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" 1.16.1.9 Ferric reductase Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to dihydroxamate rhodotorulic acid. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. {ECO:0000269|PubMed:11120744}. 1.16.1.9 Ferric reductase transmembrane component 4 (EC 1.16.1.9) (Ferric-chelate reductase 4) "FRE4; ferric-chelate reductase" Ferric REductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" 2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+ 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope cell envelope cell envelope +752 YNR073C "Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication" Mannitol dehydrogenase 1.1.1.- Mannitol dehydrogenase YNR073C (EC 1.1.1.-) "MAN2; putative mannitol dehydrogenase" 1.1.1.67 YNR073C Mannitol + NAD+ <=> D-Fructose + NADH + H+ 2 out of 5 NA Mannitol + NAD+ <=> D-Fructose + NADH + H+ YES Fructose and mannose metabolism pathway from kegg "E646;E743;H1286" Fructose and mannose metabolism NA +754 YOL005C "RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit" RNA polymerase II subunit B12.5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft. Seems to be involved transcript termination. {ECO:0000269|PubMed:16537912}. DNA-directed RNA polymerase II subunit RPB11 (RNA polymerase II subunit B11) (B13.6) (DNA-directed RNA polymerase II 13.6 kDa polypeptide) "RPB11; DNA-directed RNA polymerase II core subunit RPB11" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus +763 YOL075C Putative ABC transporter Putative ABC transporter Uncharacterized ABC transporter ATP-binding protein/permease YOL075C hypothetical protein YOL075C "ABCG5:ABCG8 transports sterols from cytosol to extracellular region;ABCG5:ABCG8 transports sterols from cytosol to extracellular region" "ABCG5:ABCG8 transports sterols from cytosol to extracellular region;ABCG5:ABCG8 transports sterols from cytosol to extracellular region" 3 out of 5 NA sterols <=> sterols YES sterols transport transports sterols from cytosol to extracellular ABC transporters in lipid homeostasis NA "vacuole;cell envelope" +766 YOL092W "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication" Putative vacuolar membrane transporter for cationic amino acids May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. {ECO:0000269|PubMed:23169667}. Probable vacuolar amino acid transporter YPQ1 (PQ-loop repeat-containing protein 1) "YPQ1; cationic amino acid transporter" Yeast PQ-loop protein PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 4 out of 5 NA "L-Arg <=> L-Arg; L-His <=> L-His; L-Lys <=> L-Lys" YES "L-Arg transport (from lysosomal lumen to cytosol); L-His transport (from lysosomal lumen to cytosol); L-Lys transport (from lysosomal lumen to cytosol)" cationic amino acids transport Miscellaneous transport and binding events NA vacuolar membrane "vacuole;cytoplasm;vacuolar membrane;endoplasmic reticulum" vacuolar membrane +777 YOL152W "Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels" 1.16.1.9 Putative ferric reductase with similarity to Fre2p Cell surface metalloreductase. May be involved in copper homeostasis. {ECO:0000269|PubMed:17553781, ECO:0000269|PubMed:17681937}. 1.16.1.9 Ferric/cupric reductase transmembrane component 7 (EC 1.16.1.9) (Ferric-chelate reductase 7) "FRE7; putative ferric-chelate reductase" Ferric REductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" 2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+ 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope cell envelope cell envelope +778 YOL157C "Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose" 3.2.1.10 Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase) Alpha-glucosidase with specificity for isomaltase, methyl-alpha-glucoside, and palatinose. {ECO:0000269|PubMed:20562106}. 3.2.1.10 Oligo-1,6-glucosidase IMA2 (EC 3.2.1.10) (Alpha-glucosidase) (Isomaltase 2) "IMA2; oligo-1,6-glucosidase IMA2" 3.2.1.10 IsoMAltase SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu "isomaltose + h2O = 2 D-glucose;Starch + H2O <=> Amylose + alpha-D-Glucose;nigerose + H2O = 2 D-glucose;alpha,alpha-trehalose + H2O = 2 beta-D-glucose;sucrose + H2O = D-fructose + alpha-D-glucose;dextrin + H2O = dextrin + beta-D-glucose;oligosaccharide + H2O = monosaccharide" "isomaltose + h2O = 2 D-glucose;Starch + H2O <=> Amylose + alpha-D-Glucose;nigerose + H2O = 2 D-glucose;alpha,alpha-trehalose + H2O = 2 beta-D-glucose;sucrose + H2O = D-fructose + alpha-D-glucose;dextrin + H2O = dextrin + beta-D-glucose;oligosaccharide + H2O = monosaccharide" "(1,4-alpha-D-glucosyl)(n) + H2O => (1,4-alpha-D-glucosyl)(n-1) + D-glucopyranose;maltose + H2O => 2 D-glucopyranose;maltotriose + H2O => maltose + D-glucopyranose" "Sucrose + H2O <=> D-Fructose + D-Glucose;Isomaltose + H2O <=> alpha-D-Glucose + D-Glucose;Dextrin + H2O <=> D-Glucose + Dextrin;Starch(n+1) + H2O <=> alpha-D-Glucose + Starch(n)" SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu 3 out of 5 Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. "Sucrose + H2O <=> D-Fructose + D-Glucose;Isomaltose + H2O <=> alpha-D-Glucose + D-Glucose;Dextrin + H2O <=> D-Glucose + Dextrin;Starch(n+1) + H2O <=> alpha-D-Glucose + Starch(n)" YES Starch and sucrose metabolism "Alpha-glucosidase with specificity for isomaltase, methyl-alpha-glucoside, and palatinose; pathway from kegg" "H432;H1196" "Galactose metabolism;Starch and sucrose metabolism;Metabolic pathways" Amino acid transport across the plasma membrane "Galactose metabolism;path:map00052;Starch and sucrose metabolism;path:map00500;Metabolic pathways;path:map01100" +779 YOL165C "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD15 has a paralog, AAD3, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" Putative aryl-alcohol dehydrogenase Putative aryl-alcohol dehydrogenase. {ECO:0000250}. 1.1.1.- Putative aryl-alcohol dehydrogenase AAD15 (EC 1.1.1.-) "AAD15; putative aryl-alcohol dehydrogenase" aryl-alcohol dehydrogenase "3-chlorobenzyl alcohol + NAD+ = 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ = 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ = 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ = p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ = 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ = an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ = benzaldehyde + NADH + H+" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism "pathway from E.coli model; reaction from biocyc" "E646;E743;H1286" NA +780 YOR002W "Alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in human ortholog ALG6 causes carbohydrate-deficient glycoprotein syndrome type-Ic; wild-type human ortholog ALG6 can partially complement yeast alg6 mutant" 2.4.1.267 Alpha 1,3 glucosyltransferase Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. {ECO:0000269|PubMed:8877369}. 2.4.1.267 Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase) "ALG6; dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase" 2.4.1.267 (mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol glucosyltransferase Addition of the first glucose to the N-glycan precursor by ALG6 "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+ Dolichyl D-glucosyl phosphate + G00007 <=> Dolichyl phosphate + G10598 5 out of 5 Dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:8877369}. Dolichyl D-glucosyl phosphate + G00007 <=> Dolichyl phosphate + G10598 YES N-Glycan biosynthesis pathway from kegg H1145 lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +787 YOR067C "Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; human homolog ALG8 can complement yeast null mutant" 2.4.1.265 Glucosyl transferase Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol. {ECO:0000269|PubMed:3536907}. 2.4.1.265 Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase) "ALG8, YOR29-18; dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase" 2.4.1.265 (glucosyl)-(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol glucosyltransferase Addition of a second glucose to the N-glycan precursor by ALG8 "alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" "alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+);alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate" "Dolichyl D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol;dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+;dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate" alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + a dolichyl phosphate + H+ Dolichyl D-glucosyl phosphate + G10598 <=> Dolichyl phosphate + G10599 4 out of 5 Dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:3536907}. Dolichyl D-glucosyl phosphate + G10598 <=> Dolichyl phosphate + G10599 YES N-Glycan biosynthesis pathway from kegg lipid-linked oligosaccharide biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Metabolic pathways" protein N-glycosylation (eukaryotic) initial steps Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +788 YOR085W "Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins" 2.4.99.18 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 (EC 2.4.99.18) (Oligosaccharyl transferase 34 kDa subunit) (Oligosaccharyl transferase subunit OST3) (Oligosaccharyl transferase subunit gamma) "OST3; dolichyl-diphosphooligosaccharide--protein glycotransferase OST3" NA "oligosaccharyl transferase complex γ subunit" "TUSC3 transports Mg2+ from extracellular region to cytosol;MAGT1 transports Mg2+ from extracellular region to cytosol;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA "TUSC3 transports Mg2+ from extracellular region to cytosol;MAGT1 transports Mg2+ from extracellular region to cytosol;Exocytosis of azurophil granule membrane proteins" 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps "Miscellaneous transport and binding events;Neutrophil degranulation" "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +790 YOR103C "Epsilon subunit of the oligosaccharyltransferase complex; located in the ER lumen; catalyzes asparagine-linked glycosylation of newly synthesized proteins" 2.4.99.18 Epsilon subunit of the oligosaccharyltransferase complex Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 2.4.99.18 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2 (Oligosaccharyl transferase subunit OST2) (EC 2.4.99.18) (Oligosaccharyl transferase 16 kDa subunit) (Oligosaccharyl transferase subunit epsilon) "OST2; dolichyl-diphosphooligosaccharide-protein glycotransferase" NA "oligosaccharyl transferase complex ε subunit" NA "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" "L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide => N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+);N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] + dolichyl diphosphate + H(+) => L-asparaginyl-[protein] + a dolichyl diphosphooligosaccharide;alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+);N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + dolichyl diphosphate + H(+) => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]" "dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine;Protein asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> Dolichyl diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn;alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-[(glucosyl)3(mannosyl)9(N-acetylglucosaminyl)2] + H+;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [glycoprotein]-L-asparagine-[oligosaccharide] + H+;dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-N-oligosaccharidyl-L-asparagine;dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + [protein]-L-asparagine-N-oligosaccharide;Campylobacter jejuni heptasaccharide bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli group 1 K30 capsule antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O16 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O7 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;peptidoglycan bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Pseudomonas aeruginosa O11 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella enterica O antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Salmonella typhimurium LT2 antigen bound to undecaprenyl diphosphate + pilin = undecaprenyl diphosphate + glycosylated pilin;Escherichia coli O86 antigen bound to farnesyl diphosphate + pilin = farnesyl diphosphate + glycosylated pilin" alpha-D-galactose 6-phosphate <=> beta-D-galactose 6-phosphate NA NA 5 out of 5 Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine YES N-Glycan biosynthesis pathway from kegg NA NA "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum" protein N-glycosylation (eukaryotic) initial steps NA "N-Glycan biosynthesis;path:map00510;Various types of N-glycan biosynthesis;path:map00513;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +792 YOR116C "RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21" 2.7.7.6 RNA polymerase III largest subunit C160 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). {ECO:0000250}. 2.7.7.6 DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (RNA polymerase III subunit C160) "RPO31, RPC1, RPC160; DNA-directed RNA polymerase III core subunit RPO31" 2.7.7.6 RNA POlymerase "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus +795 YOR149C "Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure" 2.4.1.- Alpha 1,2-mannosyltransferase Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi. Involved in plasmid maintenance with SMP2. {ECO:0000269|PubMed:11356840}. 2.4.1.- GPI mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) "SMP3, LAS2, SAP2; glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase" alpha 1,2 mannosyltransferase mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI Dolichyl phosphate D-mannose + G00149 <=> Dolichyl phosphate + G00140 4 out of 5 NA Dolichyl phosphate D-mannose + G00149 <=> Dolichyl phosphate + G00140 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H815;H837;H838;H839" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis." Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Synthesis of glycosylphosphatidylinositol (GPI) NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +796 YOR151C "RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit" 2.7.7.6 RNA polymerase II second largest subunit B150 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerases II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcription cycle, Pol II, general transcription factors and the Mediator complex assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcription elongation in which it moves on the template as the transcript elongates. Pol II appears to oscillate between inactive and active conformations at each step of nucleotide addition. Pol II is composed of mobile elements that move relative to each other. The core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. The clamp element (portions of RPB1, RPB2 and RPB3) is connected to the core through a set of flexible switches and moves to open and close the cleft. The cleft is surrounded by jaws: an upper jaw formed by portions of RBP1, RPB2 and RPB9, and a lower jaw. The jaws are thought to grab the incoming DNA template. The fork loop 1 (RPB2) interacts with the RNA-DNA hybrid, possibly stabilizing it. 2.7.7.6 DNA-directed RNA polymerase II subunit RPB2 (RNA polymerase II subunit 2) (EC 2.7.7.6) (B150) (DNA-directed RNA polymerase II 140 kDa polypeptide) "RPB2, RPB150, RPO22, SIT2, SOH2; DNA-directed RNA polymerase II core subunit RPB2" 2.7.7.6 RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus "nucleus;mitochondrion;cytoplasm" nucleus +798 YOR161C "Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport" Protein of unknown function Probably involved in transport through the plasma membrane. {ECO:0000250}. Protein PNS1 (pH nine-sensitive protein 1) "PNS1; Pns1p" pH Nine Sensitive "Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;SLC44A1 transports Cho from cytosol to mitochondrial matrix;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" "Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;SLC44A1 transports Cho from cytosol to mitochondrial matrix;Exocytosis of specific granule membrane proteins" 2 out of 5 NA choline <=> choline YES choline transport choline transporter. Choline[e] <=> choline[c] "Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Choline catabolism;Neutrophil degranulation" NA cell envelope cell envelope cell envelope +799 YOR196C "Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase" 2.8.1.8 Protein involved in biosynthesis of the coenzyme lipoic acid Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000305|PubMed:19570983, ECO:0000305|PubMed:8349643}. 2.8.1.8 Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase) "LIP5; putative lipoate synthase" 2.8.1.8 lipoyl synthase LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH "2 (sulfur carrier)-SH + 2 S-adenosyl-L-methionine + [protein]-N(6)-octanoyl-L-lysine + 2 reduced [2Fe-2S]-[ferredoxin] => 2 (sulfur carrier)-H + 2 5'-deoxyadenosine + [protein]-(R)-N(6)-lipoyl-L-lysine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin];2 (sulfur carrier)-H + 2 5'-deoxyadenosine + [protein]-(R)-N(6)-lipoyl-L-lysine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 (sulfur carrier)-SH + 2 S-adenosyl-L-methionine + [protein]-N(6)-octanoyl-L-lysine + 2 reduced [2Fe-2S]-[ferredoxin]" "Protein N6-(octanoyl)lysine + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine;Octanoyl-[acp] + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine;[glycine-cleavage complex H protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[lipoyl-carrier protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [lipoyl-carrier protein]-N6-lipoyl-L-lysine + 5'-deoxyadenosine + L-methionine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] cluster = protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] cluster;protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosine;protein N6-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = protein N6-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin" "2 (sulfur carrier)-SH + 2 S-adenosyl-L-methionine + [protein]-N(6)-octanoyl-L-lysine + 2 reduced [2Fe-2S]-[ferredoxin] => 2 (sulfur carrier)-H + 2 5'-deoxyadenosine + [protein]-(R)-N(6)-lipoyl-L-lysine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin];2 (sulfur carrier)-H + 2 5'-deoxyadenosine + [protein]-(R)-N(6)-lipoyl-L-lysine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 (sulfur carrier)-SH + 2 S-adenosyl-L-methionine + [protein]-N(6)-octanoyl-L-lysine + 2 reduced [2Fe-2S]-[ferredoxin]" "Protein N6-(octanoyl)lysine + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine;Octanoyl-[acp] + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine;[glycine-cleavage complex H protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + L-methionine + 5'-deoxyadenosine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;[lipoyl-carrier protein] N6-octanoyl-L-lysine + S-adenosyl-L-methionine + sulfurated [sulfur carrier] + reduced [2Fe-2S] ferredoxin = [lipoyl-carrier protein]-N6-lipoyl-L-lysine + 5'-deoxyadenosine + L-methionine + unsulfurated [sulfur carrier] + oxidized [2Fe-2S] ferredoxin;protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] cluster = protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] cluster;protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosine;protein N6-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = protein N6-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin" "a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier] + 2 a reduced [2Fe-2S] ferredoxin => a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 L-methionine + 2 5'-deoxyadenosine + 2 an unsulfurated [sulfur carrier] + 2 an oxidized [2Fe-2S] ferredoxin;a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier] + 2 a reduced [2Fe-2S] ferredoxin => a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + 2 L-methionine + 2 5'-deoxyadenosine + 2 an unsulfurated [sulfur carrier] + 2 an oxidized [2Fe-2S] ferredoxin;a [lipoyl-carrier protein] N6-octanoyl-L-lysine + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier] + 2 a reduced [2Fe-2S] ferredoxin => a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + 2 5'-deoxyadenosine + 2 L-methionine + 2 an unsulfurated [sulfur carrier] + 2 an oxidized [2Fe-2S] ferredoxin;a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier] + 2 a reduced [2Fe-2S] ferredoxin => a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 L-methionine + 2 5'-deoxyadenosine + 2 an unsulfurated [sulfur carrier] + 2 an oxidized [2Fe-2S] ferredoxin" "Protein N6-(octanoyl)lysine + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine;Octanoyl-[acp] + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine" NA 3 out of 5 Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin. {ECO:0000255|HAMAP-Rule:MF_03123}. "Protein N6-(octanoyl)lysine + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine;Octanoyl-[acp] + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine" YES Lipoic acid metabolism pathway from kegg "H1034;H1036" NA "PATHWAY: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03123}." "Lipoic acid metabolism;Metabolic pathways" lipoate biosynthesis and incorporation (glycine cleavage system) // superpathway of lipoate biosynthesis and incorporation (PDH, KGDH, GCV) // lipoate biosynthesis and incorporation (pyruvate dehydrogenase and oxoglutarate dehydrogenase) // lipoate biosynthesis and incorporation I Glyoxylate metabolism and glycine degradation "Lipoic acid metabolism;path:map00785;Metabolic pathways;path:map01100" mitochondrion mitochondrion mitochondrion +801 YOR207C "Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs" 2.7.7.6 Second-largest subunit of RNA polymerase III DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}. 2.7.7.6 DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 130 kDa polypeptide) "RET1, PDS2, RPC128, RPC2; DNA-directed RNA polymerase III core subunit RET1" 2.7.7.6 Reduced Efficiency of Termination "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus +803 YOR210W "RNA polymerase subunit ABC10-beta; common to RNA polymerases I, II, and III" RNA polymerase subunit ABC10-beta DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (ABC10-beta) (ABC8) (DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide) "RPB10; DNA-directed RNA polymerase core subunit RPB10" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Binding of RRN3 to RNA Polymerase I;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase I Transcription Initiation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus +805 YOR224C "RNA polymerase subunit ABC14.5; common to RNA polymerases I, II, and III" RNA polymerase subunit ABC14.5 DNA-dependent RNA polymerases catalyze the transcription. of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (ABC14.4) (ABC14.5) (DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide) "RPB8; DNA-directed RNA polymerase core subunit RPB8" RNA Polymerase B "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Binding of RRN3 to RNA Polymerase I;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase I Transcription Initiation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA nucleus nucleus nucleus +806 YOR226C "Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant" Mitochondrial protein required for iron-sulfur protein synthesis Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2. In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH. Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1. ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (By similarity). ISU2 is the minor isoform in yeast and is not detectable in cells grown to stationary phase (PubMed:10588895). {ECO:0000250|UniProtKB:Q03020, ECO:0000269|PubMed:10588895}. Iron sulfur cluster assembly protein 2, mitochondrial (Iron sulfur cluster scaffold protein 2) "ISU2, NUA2; putative iron-binding protein ISU2" ISU2 [Fe-s} cluster scaffold protein monomer "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster;Frataxin binds iron" an S-sulfanyl-[L-cysteine desulfurase] + a [disordered-form [Fe-S] cluster scaffold protein] => an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex 5 out of 5 NA an S-sulfanyl-[L-cysteine desulfurase] + a [disordered-form [Fe-S] cluster scaffold protein] => an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex YES iron-sulfur cluster biosynthesis pathway from biocyc "PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis. {ECO:0000269|PubMed:10588895, ECO:0000269|PubMed:15143178}." iron-sulfur cluster biosynthesis Mitochondrial iron-sulfur cluster biogenesis NA mitochondrion mitochondrion mitochondrion +812 YOR251C "Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized" 2.8.1.1 Rhodanese domain sulfur transferase Required for formation of the 2-thio group of the 5-methoxycarbonylmethyl-2-thiouridine modified base in some tRNAs. {ECO:0000269|PubMed:18755837}. 2.8.1.1 Thiosulfate sulfurtransferase TUM1 (EC 2.8.1.1) (Thiouridine modification protein 1) "TUM1; thiosulfate sulfurtransferase" "2.8.1.1;2.8.1.2" TUM1 sulfurtransferase "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate;2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate" "thiosulfate + cyanide = sulfite + thiocyanate + H+;sulfurated [sulfur carrier] + hydrogen cyanide = unsulfurated [sulfur carrier] + thiocyanate + H+" "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate;2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate" "thiosulfate + cyanide = sulfite + thiocyanate + H+;sulfurated [sulfur carrier] + hydrogen cyanide = unsulfurated [sulfur carrier] + thiocyanate + H+" "an [L-cysteine desulfurase] L-cysteine persulfide + a [TUM1 protein]-L-cysteine => an [L-cysteine desulfurase]-L-cysteine + a [TUM1]-S-sulfanylcysteine;thiosulfate + hydrogen cyanide => sulfite + thiocyanate + 2 H+" "Thiosulfate + Cyanide ion <=> Sulfite + Thiocyanate;Mercaptopyruvate + Sulfite <=> Thiosulfate + Pyruvate;Hydrogen cyanide + Mercaptopyruvate <=> Thiocyanate + Pyruvate" 4 out of 5 Thiosulfate + cyanide = sulfite + thiocyanate. hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate YES Sulfur metabolism "pathway from kegg; reaction from rhea" "E405;H677;H1177" "Cysteine and methionine metabolism;Sulfur metabolism;Metabolic pathways;Sulfur relay system" tRNA-uridine 2-thiolation (yeast mitochondria) // thiosulfate disproportionation III (rhodanese) "Sulfur metabolism;path:map00920;Microbial metabolism in diverse environments;path:map01120" "mitochondrion;cytoplasm" "cytoplasm;mitochondrion" "mitochondrion;cytoplasm" +818 YOR283W "Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene" 3.1.3.- Phosphatase with a broad substrate specificity Metal-independent phosphatase active against a broad range of phosphorylated substrates including nucleoside tri- and diphosphates, phosphorylated organic acids, and amino acids. Shows no activity against phytic acid, phosphorylated carbohydrates, and nucleoside monophosphates. {ECO:0000269|PubMed:19753119, ECO:0000269|PubMed:20427268}. 3.1.3.- Broad-specificity phosphatase YOR283W (EC 3.1.3.-) phosphoglycerate mutase 5.4.2.12 YOR283W TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate 2-phospho-D-glycerate <=> 3-phospho-D-glycerate 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate 3 out of 5 NA 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate YES Glycolysis / Gluconeogenesis pathway from kegg "E88;E587;H1052" "Glycolysis / Gluconeogenesis;Glycine, serine and threonine metabolism;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids" gluconeogenesis // glycolysis TP53 Regulates Metabolic Genes NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +819 YOR285W "Thiosulfate sulfurtransferase; contains a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress; similar to the human TSTD gene" 2.8.1.1 Thiosulfate sulfurtransferase Thiosulfate:glutathione sulfurtransferase (TST) required to produce glutathione persulfide (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). {ECO:0000269|PubMed:24981631}. 2.8.1.- Thiosulfate:glutathione sulfurtransferase (TST) (EC 2.8.1.-) (Rhodanese-like protein 1) "RDL1; thiosulfate sulfurtransferase RDL1" RhoDanese-Like protein Thiosulfate can transfer its sulfur atom to glutathione "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate;2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate" "thiosulfate + cyanide = sulfite + thiocyanate + H+;sulfurated [sulfur carrier] + hydrogen cyanide = unsulfurated [sulfur carrier] + thiocyanate + H+" thiosulfate + hydrogen cyanide => sulfite + thiocyanate + 2 H+ Thiosulfate can transfer its sulfur atom to glutathione 5 out of 5 NA hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate YES Sulfur metabolism "pathway from kegg; reaction from rhea" H1233 thiosulfate disproportionation III (rhodanese) Sulfide oxidation to sulfate NA mitochondrion "mitochondrion;mitochondrial membrane;endoplasmic reticulum" mitochondrion +820 YOR286W "Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss" 2.8.1.1 Protein with rhodanese activity Thiosulfate sulfurtransferase which catalyzes the transfer of sulfane sulfur from thiosulfate to cyanide. {ECO:0000269|PubMed:19864628}. 2.8.1.1 Thiosulfate sulfurtransferase RDL2, mitochondrial (EC 2.8.1.1) (Altered inheritance of mitochondria protein 42) (Found in mitochondrial proteome protein 31) (Rhodanese-like protein 2) "RDL2, AIM42; thiosulfate sulfurtransferase RDL2" "thiosulfate—thiol sulfurtransferase" Thiosulfate can transfer its sulfur atom to glutathione "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate;2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate" "thiosulfate + cyanide = sulfite + thiocyanate + H+;sulfurated [sulfur carrier] + hydrogen cyanide = unsulfurated [sulfur carrier] + thiocyanate + H+" "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate;2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate" "thiosulfate + cyanide = sulfite + thiocyanate + H+;sulfurated [sulfur carrier] + hydrogen cyanide = unsulfurated [sulfur carrier] + thiocyanate + H+" thiosulfate + 2 a thiol = sulfite + hydrogen sulfide + a disulfide + H+ Thiosulfate can transfer its sulfur atom to glutathione 4 out of 5 Thiosulfate + cyanide = sulfite + thiocyanate. hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate YES Sulfur metabolism "pathway from kegg; reaction from rhea" "E405;H677;H1177" Sulfide oxidation to sulfate "Sulfur metabolism;path:map00920;Microbial metabolism in diverse environments;path:map01120" mitochondrion mitochondrion mitochondrion +823 YOR316C "Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication" Vacuolar transporter that mediates zinc transport into the vacuole Probably responsible for the uptake of cobalt ions. It appears to act in a dosage-dependent manner to counteract the adverse effects of cobalt ions on cells. It may participate in the regulation of cobalt levels under normal physiological conditions and may be important in the supply of metal that is required for metalloenzyme or cofactor synthesis. It reduces the toxicity of cobalt and rhodium ions. Other components responsible for cobalt transport exist. Cobalt uptake protein COT1 "COT1; metal cation transporter COT1" CObalt Toxicity "ZnT1 mediates the efflux of zinc from the cell;SLC30A8 transports Zn2+ from cytosol to secretory granule;SLC30A10 transports Mn2+ from cytosol to extracellular region" ZnT1 mediates the efflux of zinc from the cell 5 out of 5 NA Zn2+ <=> Zn2+ YES zinc transport Zn2+ transport "Insulin processing;Metal ion SLC transporters;Zinc efflux and compartmentalization by the SLC30 family" NA mitochondrial membrane "vacuole;mitochondrion;mitochondrial membrane" mitochondrial membrane +824 YOR330C "Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occur more frequently in some lab strains; human ortholog POLG complements yeast mip1 mutant; mutations in human POLG associated with Alpers-Huttenlocher syndrome (AHS), progressive external ophthalmoplegia (PEO), parkinsonism, other mitochondrial diseases" 2.7.7.7 Mitochondrial DNA polymerase gamma Involved in the replication of mitochondrial DNA. 2.7.7.7 DNA polymerase gamma (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) "MIP1; DNA-directed DNA polymerase gamma MIP1" 2.7.7.7 MItochondrial DNA Polymerase "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate 4 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication Mitochondrial DNA polymerase gamma H1117 "Metabolic pathways;Mitophagy - yeast" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" mitochondrion mitochondrion mitochondrion +825 YOR334W "Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA" Mitochondrial inner membrane Mg(2+) channel High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix (PubMed:12628916, PubMed:17827224, PubMed:20653776, PubMed:23999289). Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes (PubMed:11544180). {ECO:0000269|PubMed:11544180, ECO:0000269|PubMed:12628916, ECO:0000269|PubMed:17827224, ECO:0000269|PubMed:20653776, ECO:0000269|PubMed:23999289}. Magnesium transporter MRS2, mitochondrial (RNA-splicing protein MRS2) "MRS2; Mrs2p" Mitochondrial RNA Splicing MRS2 transports Mg2+ from cytosol to mitochondrial matrix MRS2 transports Mg2+ from cytosol to mitochondrial matrix 5 out of 5 NA Mg2+ <=> Mg2+ YES magnesium transport Mg2+ transport Miscellaneous transport and binding events NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +827 YOR340C RNA polymerase I subunit A43 RNA polymerase I subunit A43 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. Through its association with RRN3 is involved in recruitment of Pol I to rDNA promoters. In vitro, the A13-A43 subcomplex binds single-stranded RNA. {ECO:0000269|PubMed:11032814, ECO:0000269|PubMed:12888498, ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerase I subunit RPA43 (A43) (DNA-directed DNA-dependent RNA polymerase 36 kDa polypeptide) "RPA43; DNA-directed RNA polymerase I subunit RPA43" RNA Polymerase A a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 4 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA nucleus nucleus nucleus +828 YOR341W RNA polymerase I largest subunit A190 2.7.7.6 RNA polymerase I largest subunit A190 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. RPA190 and RPA135 both contribute to the polymerase catalytic activity and together form the Pol I active center. In addition, subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA190 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. 2.7.7.6 DNA-directed RNA polymerase I subunit RPA190 (EC 2.7.7.6) (DNA-directed RNA polymerase I 190 kDa polypeptide) (A190) (DNA-directed RNA polymerase I largest subunit) "RPA190, RRN1; DNA-directed RNA polymerase I core subunit RPA190" 2.7.7.6 RNA Polymerase A Binding of RRN3 to RNA Polymerase I "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus +830 YOR356W "Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase" 1.5.5.1 Putative ortholog of human ETF-dH Accepts electrons from ETF and reduces ubiquinone. {ECO:0000250}. 1.5.5.1 Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Changed intracellular redox state protein 2) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase) "CIR2; putative electron-transferring-flavoprotein dehydrogenase" 1.5.5.1 Changed Intracellular Redox state ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 "a ubiquinone + reduced [electron-transfer flavoprotein] => a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein];a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] => a ubiquinone + reduced [electron-transfer flavoprotein]" "reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol;reduced electron-transfer flavoprotein + ubiquinone = oxidized electron-transfer flavoprotein + ubiquinol + H+;ubiquinone + reduced electron-transfer flavoprotein = ubiquinol + oxidized electron-transfer flavoprotein + H+" "a ubiquinone + reduced [electron-transfer flavoprotein] => a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein];a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] => a ubiquinone + reduced [electron-transfer flavoprotein]" "reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol;reduced electron-transfer flavoprotein + ubiquinone = oxidized electron-transfer flavoprotein + ubiquinol + H+;ubiquinone + reduced electron-transfer flavoprotein = ubiquinol + oxidized electron-transfer flavoprotein + H+" a reduced electron-transfer flavoprotein + ubiquinone-6 = an oxidized electron-transfer flavoprotein + ubiquinol-6 + H+ 5 out of 5 Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol. a ubiquinone + reduced [electron-transfer flavoprotein] <=> a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] YES Respiratory electron transport "pathway from reactome; reaction from rhea" "H215;H1270" Respiratory electron transport NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +833 YOR381W "Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" 1.16.1.9 Ferric reductase Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to di- and trihydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. {ECO:0000269|PubMed:11120744}. 1.16.1.9 Ferric reductase transmembrane component 3 (EC 1.16.1.9) (Ferric-chelate reductase 3) "FRE3; ferric-chelate reductase" ferric reductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+;2 an Fe(III)-siderophore + NADPH => 2 Fe2+ + 2 a siderophore + NADP+ + H+;2 ferric (2,3-dihydroxybenzoylserine)3 + NADPH + 9 H+ => 2 Fe2+ + 2 (2,3-dihydroxybenzoylserine)3 + NADP+" 5 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope "vacuole;cell envelope" cell envelope +834 YOR384W "Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" 1.16.1.9 Putative ferric reductase with similarity to Fre2p Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity). {ECO:0000250}. 1.16.1.9 Ferric reductase transmembrane component 5 (EC 1.16.1.9) (Ferric-chelate reductase 5) "FRE5; putative ferric-chelate reductase" Ferric REductase "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH;2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)" "2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH;2 Fe2+ + NADP+ + H+ <=> 2 Fe3+ + NADPH;Fe2+ + siderophore + NADP+ + H+ = Fe(III)-siderophore + NADPH;Fe2+ + (2,3-dihydroxybenzoylserine)3 + NADP+ = ferric (2,3-dihydroxybenzoylserine)3 + NADPH + H+" 2 an Fe(III)-siderophore + NADH => 2 an Fe(II)-siderophore + NAD+ + H+ 4 out of 5 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH YES ferric-chelate reductase "no pathway from database; reaction from rhea" ethylene biosynthesis NA cell envelope "mitochondrion;cell envelope" cell envelope +836 YOR391C "Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer" "3.2.-.-;4.2.1.130" Possible chaperone and cysteine protease Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893). {ECO:0000250|UniProtKB:Q04432, ECO:0000269|PubMed:24706893}. 4.2.1.130 Probable glutathione-independent glyoxalase HSP33 (EC 4.2.1.130) (Glyoxalase 3 homolog 3) (Heat shock protein 33) "HSP33; glutathione-independent methylglyoxalase family protein" Heat-Shock Protein "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O 4 out of 5 (R)-lactate = methylglyoxal + H(2)O. {ECO:0000250|UniProtKB:Q04432}. (R)-lactate <=> methylglyoxal + H2O YES Methylglyoxal Metabolism pathway from e.coli model E513 "Pyruvate metabolism;path:map00620;Microbial metabolism in diverse environments;path:map01120" cytoplasm cytoplasm cytoplasm +837 YOR393W Putative phosphopyruvate hydratase 4.2.1.11 Putative phosphopyruvate hydratase 4.2.1.11 Enolase-related protein 1 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) "ERR1; phosphopyruvate hydratase ERR1" 4.2.1.11 enolase "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O 3 out of 5 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O. 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O YES Glycolysis / Gluconeogenesis pathway from kegg "E61;H213" "PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5." "Glycolysis / Gluconeogenesis;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids;RNA degradation" gluconeogenesis // glycolysis // glycolysis III (from glucose) "Glycolysis / Gluconeogenesis;path:map00010;Methane metabolism;path:map00680;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" None +839 YPL006W "Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p" Vacuolar membrane protein Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments. {ECO:0000269|PubMed:14970192, ECO:0000269|PubMed:16138904}. Niemann-Pick type C-related protein 1 "NCR1; sphingolipid transporter" Niemann-pick type C Related "NPC1L1 inactivation by ezetimibe;PTCH is internalized;PTCH is internalized;SMURF1/2 dissociates from ub-PTCH1;CHOL translocates from lysosome membrane to ER membrane" CHOL translocates from lysosome membrane to ER membrane 4 out of 5 NA sphingolipid <=> sphingolipid YES sphingolipid transport "sphingolipid transporter; sphingolipid[c] <=> sphingolipid[er]" "Hedgehog 'on' state;Intestinal lipid absorption;LDL clearance" NA vacuolar membrane "vacuole;vacuolar membrane;endoplasmic reticulum" vacuolar membrane +848 YPL060W "Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p" Mitochondrial inner membrane magnesium transporter Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. {ECO:0000269|PubMed:11254124, ECO:0000269|PubMed:17827224, ECO:0000269|PubMed:20653776}. Mitochondrial inner membrane magnesium transporter MFM1 (MRS2 function modulating factor 1) "MFM1, LPE10; Mfm1p" Mrs2 Function Modulating factor MRS2 transports Mg2+ from cytosol to mitochondrial matrix MRS2 transports Mg2+ from cytosol to mitochondrial matrix 4 out of 5 NA Mg2+ <=> Mg2+ YES magnesium transport Mg2+ transport Miscellaneous transport and binding events NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +851 YPL076W "Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol" 2.4.1.198 Protein involved in the synthesis of GlcNAc-PI Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. {ECO:0000269|PubMed:7768896}. 2.4.1.198 Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit (GPI-GlcNAc transferase complex subunit GPI2) (GPI-GnT subunit GPI2) (EC 2.4.1.198) "GPI2, GCR4; phosphatidylinositol N-acetylglucosaminyltransferase" GlycosylPhosphatidylInositol anchor biosynthesis "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" an L-1-phosphatidyl-inositol + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H+ UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 4 out of 5 UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol. UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H479;H1129" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000305|PubMed:7768896}." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;path:map00563;Metabolic pathways;path:map01100" "endoplasmic reticulum;endoplasmic reticulum membrane" +854 YPL088W "Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance" Putative aryl alcohol dehydrogenase Putative aryl-alcohol dehydrogenase. {ECO:0000250}. 1.1.1.- Putative aryl-alcohol dehydrogenase AAD16 (EC 1.1.1.-) aldo-keto reductase superfamily protein YPL088W "AKR dimers reduce AFBDHO to AFBDOH;AKR dimers reduce AFBDHO to AFBDOH;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" "AKR dimers reduce AFBDHO to AFBDOH;AKR dimers reduce AFBDHO to AFBDOH" 2 out of 5 NA "3-chlorobenzyl alcohol + NAD+ <=> 3-chlorobenzaldehyde + NADH + H+;3-hydroxybenzyl alcohol + NAD+ <=> 3-hydroxybenzaldehyde + NADH + H+;3-methylbenzyl alcohol + NAD+ <=> 3-methylbenzaldehyde + NADH + H+;4-isopropylbenzyl alcohol + NAD+ <=> p-cumic aldehyde + NADH + H+;4-methylbenzyl alcohol + NAD+ <=> 4-methylbenzaldehyde + NADH + H+;a phenol + NAD+ <=> an aryl aldehyde + NADH + H+;benzyl alcohol + NAD+ <=> benzaldehyde + NADH + H+" YES Methylglyoxal Metabolism pathway from kegg "E646;E743;H1286" "Aflatoxin activation and detoxification;Neutrophil degranulation" NA +861 YPL132W "Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p" NA Protein required for delivery of copper to Cox1p Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. {ECO:0000250}. NA Cytochrome c oxidase assembly protein COX11, mitochondrial "COX11, LPI13, PSO7; Cox11p" NA Cytochrome c OXidase NA NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 4 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA "Oxidative phosphorylation;Metabolic pathways" aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +862 YPL135W "Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant" Conserved protein of the mitochondrial matrix Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2. In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH. Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1. ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (PubMed:10588895, PubMed:12970193, PubMed:14741370, PubMed:15123690, PubMed:16341089, PubMed:16431909, PubMed:23615440, PubMed:25358379). {ECO:0000269|PubMed:10588895, ECO:0000269|PubMed:12970193, ECO:0000269|PubMed:14741370, ECO:0000269|PubMed:15123690, ECO:0000269|PubMed:16341089, ECO:0000269|PubMed:16431909, ECO:0000269|PubMed:23615440, ECO:0000269|PubMed:25358379}. Iron sulfur cluster assembly protein 1, mitochondrial (Iron sulfur cluster scaffold protein 1) "ISU1, NUA1; iron-binding protein ISU1" ISU1 [Fe-S] cluster scaffold protein monomer "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster;Frataxin binds iron" an S-sulfanyl-[L-cysteine desulfurase] + a [disordered-form [Fe-S] cluster scaffold protein] => an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex 5 out of 5 NA an S-sulfanyl-[L-cysteine desulfurase] + a [disordered-form [Fe-S] cluster scaffold protein] => an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex YES iron-sulfur cluster biosynthesis "Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters; pathway from kegg" "PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis. {ECO:0000269|PubMed:10588895, ECO:0000269|PubMed:15123690, ECO:0000269|PubMed:15143178, ECO:0000269|PubMed:16431909}." iron-sulfur cluster biosynthesis Mitochondrial iron-sulfur cluster biogenesis NA mitochondrion mitochondrion mitochondrion +870 YPL167C "Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev7p, Pol31p and Pol32p" 2.7.7.7 Catalytic subunit of DNA polymerase zeta Nonessential DNA polymerase. Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Translesion synthesis in S.cerevisiae may use a specialized DNA polymerase that is not required for other DNA replicative processes. Has a role in the bypass of abasic (AP) sites. Highly inefficient in incorporating nucleotides opposite the AP site, but efficiently extends from nucleotides, particularly an A, inserted opposite the lesion. {ECO:0000269|PubMed:11316789, ECO:0000269|PubMed:16452144, ECO:0000269|PubMed:2676986, ECO:0000269|PubMed:8658138}. 2.7.7.7 DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3) "REV3, PSO1; Rev3p" 2.7.7.7 REVersionless "POLK incorporates dNMP opposite to damaged DNA base;POLI incorporates dNMP opposite to damaged DNA base" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). {ECO:0000269|PubMed:11316789}. 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication DNA synthesis . Nonessential DNA polymerase H1117 Metabolic pathways "Translesion synthesis by POLK;Translesion synthesis by POLI" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" "mitochondrion;nucleus" "nucleus;mitochondrion" "mitochondrion;nucleus" +871 YPL171C "Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death" 1.6.99.1 Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) Oxidizes beta-NADH, beta-NADPH, and alpha-NADPH. 1.6.99.1 NADPH dehydrogenase 3 (EC 1.6.99.1) (Old yellow enzyme 3) "OYE3, ZRG6; NADPH dehydrogenase" 1.6.99.1 NADPH dehydrogenase "NADPH + H+ + acceptor = NADP+ + reduced acceptor;2-cyclohexen-1-one + NADPH + H+ = cyclohexanone + NADP+" "NADPH + H+ + acceptor = NADP+ + reduced acceptor;2-cyclohexen-1-one + NADPH + H+ = cyclohexanone + NADP+" an oxidized electron acceptor + NADPH + H+ = a reduced electron acceptor + NADP+ Acceptor + NADPH + H+ <=> Reduced acceptor + NADP+ 4 out of 5 NADPH + acceptor = NADP(+) + reduced acceptor. Acceptor + NADPH + H+ <=> Reduced acceptor + NADP+ YES other NA +872 YPL175W "UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins" 2.4.1.198 UDP-glycosyltransferase subunit of the GPI-GnT complex Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. {ECO:0000269|PubMed:10970797, ECO:0000269|PubMed:7768896}. 2.4.1.198 Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit (GPI-GlcNAc transferase complex subunit GPI3) (GPI-GnT subunit GPI3) (EC 2.4.1.198) (GlcNAc-PI synthesis protein) "SPT14, CWH6, GPI3; phosphatidylinositol N-acetylglucosaminyltransferase SPT14" 2.4.1.198 SuPpressor of Ty "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP;a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine" "UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol;UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + alpha-D-GlcNAc-(1->6)-Ino-P" an L-1-phosphatidyl-inositol + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H+ UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 5 out of 5 UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol. UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway from kegg "H479;H1129" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000305|PubMed:7737116}." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;path:map00563;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane;cytoplasm" endoplasmic reticulum membrane +879 YPL227C "UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant" 2.4.1.117 UDP-glucose:dolichyl-phosphate glucosyltransferase 2.4.1.117 Dolichyl-phosphate beta-glucosyltransferase (DolP-glucosyltransferase) (EC 2.4.1.117) (Asparagine-linked glycosylation protein 5) "ALG5; dolichyl-phosphate beta-glucosyltransferase" 2.4.1.117 UDP-glucose:dolichyl-phosphate glucosyltransferase Synthesis of dolichyl-phosphate-glucose "dolichyl phosphate + UDP-alpha-D-glucose => dolichyl beta-D-glucosyl phosphate + UDP;dolichyl beta-D-glucosyl phosphate + UDP => dolichyl phosphate + UDP-alpha-D-glucose" UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate "dolichyl phosphate + UDP-alpha-D-glucose => dolichyl beta-D-glucosyl phosphate + UDP;dolichyl beta-D-glucosyl phosphate + UDP => dolichyl phosphate + UDP-alpha-D-glucose" UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate a dolichyl phosphate + UDP-alpha-D-glucose => a dolichyl beta-D-glucosyl phosphate + UDP UDP-glucose + Dolichyl phosphate <=> UDP + Dolichyl beta-D-glucosyl phosphate 3 out of 5 UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate. UDP-glucose + Dolichyl phosphate <=> UDP + Dolichyl beta-D-glucosyl phosphate YES N-Glycan biosynthesis pathway from kegg "H569;H1144" dolichyl glucosyl phosphate biosynthesis "PATHWAY: Protein modification; protein glycosylation." "N-Glycan biosynthesis;Metabolic pathways" dolichyl glucosyl phosphate biosynthesis // protein N-glycosylation (eukaryotic) initial steps Synthesis of dolichyl-phosphate-glucose "N-Glycan biosynthesis;path:map00510;Metabolic pathways;path:map01100" endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane +886 YPL280W "Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer" "3.2.-.-;4.2.1.130" Possible chaperone and cysteine protease Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893). {ECO:0000250|UniProtKB:Q04432, ECO:0000269|PubMed:24706893}. 4.2.1.130 Probable glutathione-independent glyoxalase HSP32 (EC 4.2.1.130) (Glyoxalase 3 homolog 2) (Heat shock protein 32) "HSP32; glutathione-independent methylglyoxalase family protein" Heat-Shock Protein "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O "2-oxopropanal + H2O => (R)-lactate + H(+);(R)-lactate + H(+) => 2-oxopropanal + H2O" (R)-lactate = methylglyoxal + H2O 4 out of 5 (R)-lactate = methylglyoxal + H(2)O. {ECO:0000250|UniProtKB:Q04432}. (R)-lactate <=> methylglyoxal + H2O YES Methylglyoxal Metabolism pathway from e.coli model E513 "Pyruvate metabolism;path:map00620;Microbial metabolism in diverse environments;path:map01120" cytoplasm cytoplasm cytoplasm +887 YPL281C "Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant" 4.2.1.11 Enolase, a phosphopyruvate hydratase 4.2.1.11 Enolase-related protein 2 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) "ERR2; phosphopyruvate hydratase ERR2" 4.2.1.11 enolase "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" "2-phospho-D-glycerate => H2O + phosphoenolpyruvate;H2O + phosphoenolpyruvate => 2-phospho-D-glycerate" "2-phospho-D-glycerate = phosphoenolpyruvate + H2O;3-Phospho-D-erythronate <=> Phosphoenol-4-deoxy-3-tetrulosonate + H2O;2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+ = 3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O" 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O 3 out of 5 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O. 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O YES Glycolysis / Gluconeogenesis pathway from kegg "E61;H213" "PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5." "Glycolysis / Gluconeogenesis;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids;RNA degradation" gluconeogenesis // glycolysis // glycolysis III (from glucose) "Glycolysis / Gluconeogenesis;path:map00010;Methane metabolism;path:map00680;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110;Microbial metabolism in diverse environments;path:map01120;Biosynthesis of antibiotics;path:map01130" None +889 YPR003C "Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene" Putative sulfate permease Possible sulfate transporter. Putative sulfate transporter YPR003C hypothetical protein YPR003C "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol;SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol;Group 3 - Selective Cl- transport;Group 3 - Selective Cl- transport;SLC26A3,6 exchange Cl- for HCO3-;SLC26A3,6 exchange Cl- for HCO3-;SLC26A4 transports I- from cytosol to extracellular region" "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol;SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol;Group 3 - Selective Cl- transport;Group 3 - Selective Cl- transport;SLC26A3,6 exchange Cl- for HCO3-;SLC26A3,6 exchange Cl- for HCO3-;SLC26A4 transports I- from cytosol to extracellular region" 3 out of 5 NA SO4(2-) <=> SO4(2-) YES sulfate transport Putative sulfate permease "Transport and synthesis of PAPS;Multifunctional anion exchangers" NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane;cell envelope" endoplasmic reticulum membrane +890 YPR010C RNA polymerase I second largest subunit A135 2.7.7.6 RNA polymerase I second largest subunit A135 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. RPA190 and RPA135 both contribute to the polymerase catalytic activity and together form the Pol I active center. In addition, subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA190 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. 2.7.7.6 DNA-directed RNA polymerase I subunit RPA135 (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (A135) (DNA-directed RNA polymerase I polypeptide 2) (RNA polymerase I subunit 2) "RPA135, RPA2, RRN2, SRP3; DNA-directed RNA polymerase I core subunit RPA135" 2.7.7.6 RNA Polymerase A Binding of RRN3 to RNA Polymerase I "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" "a ribonucleoside 5'-triphosphate + RNAn => diphosphate + RNAn+1;diphosphate + RNAn+1 => a ribonucleoside 5'-triphosphate + RNAn" "Nucleoside triphosphate + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA;ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;n Nucleoside triphosphate <=> 5'-Triphospho-[mRNA](n) + (n-1) Diphosphate;nucleoside triphosphate + RNAn = diphosphate + RNAn+1;GTP + RNAn = diphosphate + RNAn+1;CTP + RNAn = diphosphate + RNAn+1;ATP + RNAn = diphosphate + RNAn+1" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg H1118 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" nucleus nucleus nucleus +899 YPR110C "RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes" RNA polymerase subunit AC40 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I (Pol I) and III (Pol III) which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPC40 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft (PubMed:18160037, PubMed:24153182, PubMed:24153184). Plays an important role in targeting retrotransposons Ty integration upstream of pol III-transcribed genes such as tRNA genes, allowing Ty1, Ty2 and Ty4 to proliferate and yet minimizing genetic damage (PubMed:25931562). {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184, ECO:0000269|PubMed:25931562, ECO:0000305|PubMed:10384303}. DNA-directed RNA polymerases I and III subunit RPAC1 (RNA polymerases I and III subunit AC1) (C37) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (AC40) (C40) "RPC40, RPC5; DNA-directed RNA polymerase core subunit RPC40" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;Binding of RRN3 to RNA Polymerase I" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" RNA Polymerase I Transcription Initiation NA nucleus nucleus nucleus +901 YPR127W "Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" 1.1.1.65 Putative pyridoxine 4-dehydrogenase Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+). {ECO:0000250}. 1.1.1.65 Putative pyridoxal reductase (PL reductase) (PL-red) (EC 1.1.1.65) pyridoxine 4-dehydrogenase 1.1.1.65 pyridoxine 4-dehydrogenase "NADP(+) + pyridoxine => H(+) + NADPH + pyridoxal;H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine" pyridoxine + NADP+ = pyridoxal + NADPH + H+ "NADP(+) + pyridoxine => H(+) + NADPH + pyridoxal;H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine" pyridoxine + NADP+ = pyridoxal + NADPH + H+ pyridoxine + NADP+ <=> pyridoxal + NADPH + H+ Pyridoxine + NADP+ <=> Pyridoxal + NADPH + H+ 3 out of 5 Pyridoxine + NADP(+) = pyridoxal + NADPH. Pyridoxine + NADP+ <=> Pyridoxal + NADPH + H+ YES Vitamin B6 metabolism pathway from kegg "PATHWAY: Cofactor degradation; B6 vitamer degradation; pyridoxal from pyridoxine (dehydrogenase route): step 1/1." "Vitamin B6 metabolism;Metabolic pathways" superpathway of thiamin diphosphate biosynthesis III (eukaryotes) // 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis "Vitamin B6 metabolism;path:map00750;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +903 YPR139C "Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA" 2.3.1.51 Lysophosphatidic acid acyltransferase Acyl-CoA-dependent lysophosphatidic acid acyltransferase with preference for oleoyl-CoA. Involved in triacylglyceride homeostasis and lipid droplet formation. Involved in vacuolar protein sorting. {ECO:0000269|PubMed:12134085, ECO:0000269|PubMed:22090344}. 2.3.1.51 Lysophosphatidic acid:oleoyl-CoA acyltransferase 1 (LPAAT) (Lysophosphatidic acid acyltransferase) (EC 2.3.1.51) (Vacuolar protein sorting-associated protein 66) "LOA1, VPS66; lysophosphatidic acid acyltransferase LOA1" oleoyl-CoA: lysophosphatidate acyltransferase "1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA;a 1,2-diacyl-sn-glycero-3-phosphate + CoA => 1-acyl-sn-glycero-3-phosphate + an acyl-CoA" "acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate;palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate;acyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate;1-oleoyl-sn-glycerol-3-phosphate + oleoyl-CoA = CoA + 1,2-oleoyl-sn-glycerol-3-phosphate;2,3-Dehydroacyl-CoA + 1-Acyl-sn-glycerol 3-phosphate <=> CoA + Phosphatidate;palmitoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];long-chain acyl-[acyl-carrier protein] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl 2-acyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];stearoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-stearoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];oleoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];18-hydroxylinoleoyl-CoA + 1-[18-hydroxyoleyl]-2-lyso-phosphatidate = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + coenzyme A;palmitoleoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-CoA + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];myristoyl-CoA + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + coenzyme A;myristoyl-[acp] + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + holo-[acyl-carrier protein];1-palmitoylglycerol 3-phosphate + myristoyl-CoA = 1-palmitoyl-2-myristoyl phosphatidate + coenzyme A;1-palmitoylglycerol 3-phosphate + myristoyl-[acp] = 1-palmitoyl-2-myristoyl phosphatidate + holo-[acyl-carrier protein];long-chain acyl-CoA + 1-alkyl-sn-glycerol 3-phosphate = 2-acyl-1-alkyl-sn-glycerol 3-phosphate + coenzyme A;2,3,4-saturated fatty acyl-[acp] + 2,3,4-saturated 2-lysophosphatidate = 2,3,4-saturated L-phosphatidate + holo-[acyl-carrier protein];palmitoyl-[acp] + 1-palmitoylglycerol 3-phosphate = dipalmitoyl phosphatidate + holo-[acyl-carrier protein];oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol = CoA + 1,2-dioleoyl-sn-phosphatidylinositol;myristoyl-CoA + 1-myristoyl-sn-glycerol 3-phosphate = CoA + 1,2-dimyristoyl-sn-glycerol 3-phosphate;lauroyl-CoA + 1-lauroyl-sn-glycerol 3-phosphate = CoA + 1,2-dilauroyl-sn-glycerol 3-phosphate;arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate" "1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA;a 1,2-diacyl-sn-glycero-3-phosphate + CoA => 1-acyl-sn-glycero-3-phosphate + an acyl-CoA" "acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate;palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate;acyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate;1-oleoyl-sn-glycerol-3-phosphate + oleoyl-CoA = CoA + 1,2-oleoyl-sn-glycerol-3-phosphate;2,3-Dehydroacyl-CoA + 1-Acyl-sn-glycerol 3-phosphate <=> CoA + Phosphatidate;palmitoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-palmitoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];long-chain acyl-[acyl-carrier protein] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl 2-acyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];stearoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-stearoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];oleoyl-[acp] + 1-stearoyl-sn-glycerol 3-phosphate = 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphate + holo-[acyl-carrier protein];18-hydroxylinoleoyl-CoA + 1-[18-hydroxyoleyl]-2-lyso-phosphatidate = 1-[18-hydroxyoeoyl]-2-[18-hydroxy-lioleoyl]-sn-glycerol 3-phosphate + coenzyme A;palmitoleoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + coenzyme A;cis-vaccenoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-palmitoylglycerol 3-phosphate = 1-palmitoyl-2-cis-vaccenoyl phosphatidate + holo-[acyl-carrier protein];cis-vaccenoyl-[acp] + 1-cis-vaccenoylglycerol-3-phosphate = 1,2-dicis-vaccenoyl-phosphatidate + holo-[acyl-carrier protein];palmitoleoyl-CoA + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + coenzyme A;palmitoleoyl-[acp] + 1-myristoylglycerol 3-phosphate = 1-myristoyl-2-palmitoleoyl phosphatidate + holo-[acyl-carrier protein];myristoyl-CoA + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + coenzyme A;myristoyl-[acp] + 1-myristoylglycerol 3-phosphate = dimyristoyl phosphatidate + holo-[acyl-carrier protein];1-palmitoylglycerol 3-phosphate + myristoyl-CoA = 1-palmitoyl-2-myristoyl phosphatidate + coenzyme A;1-palmitoylglycerol 3-phosphate + myristoyl-[acp] = 1-palmitoyl-2-myristoyl phosphatidate + holo-[acyl-carrier protein];long-chain acyl-CoA + 1-alkyl-sn-glycerol 3-phosphate = 2-acyl-1-alkyl-sn-glycerol 3-phosphate + coenzyme A;2,3,4-saturated fatty acyl-[acp] + 2,3,4-saturated 2-lysophosphatidate = 2,3,4-saturated L-phosphatidate + holo-[acyl-carrier protein];palmitoyl-[acp] + 1-palmitoylglycerol 3-phosphate = dipalmitoyl phosphatidate + holo-[acyl-carrier protein];oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol = CoA + 1,2-dioleoyl-sn-phosphatidylinositol;myristoyl-CoA + 1-myristoyl-sn-glycerol 3-phosphate = CoA + 1,2-dimyristoyl-sn-glycerol 3-phosphate;lauroyl-CoA + 1-lauroyl-sn-glycerol 3-phosphate = CoA + 1,2-dilauroyl-sn-glycerol 3-phosphate;arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate" 1-oleyl-2-lyso-phosphatidate + oleoyl-CoA => dioleoyl phosphatidate + coenzyme A 4 out of 5 Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. {ECO:0000269|PubMed:22090344}. Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate <=> CoA + 1,2-diacyl-sn-glycerol 3-phosphate YES "Glycerolipid metabolism;Glycerophospholipid metabolism" pathway from kegg "E705;H70;H787" superpathway phosphatidate biosynthesis (yeast) // phospholipid remodeling (phosphatidate) "Glycerolipid metabolism;path:map00561;Glycerophospholipid metabolism;path:map00564;Metabolic pathways;path:map01100;Biosynthesis of secondary metabolites;path:map01110" "lipid particle;endoplasmic reticulum membrane" "cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;lipid particle" "endoplasmic reticulum membrane;lipid particle" +906 YPR175W "Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate" 2.7.7.7 Second largest subunit of DNA polymerase II (DNA polymerase epsilon) DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. {ECO:0000269|PubMed:12124389}. 2.7.7.7 DNA polymerase epsilon subunit B (EC 2.7.7.7) (DNA polymerase II subunit 2) "DPB2; DNA polymerase epsilon noncatalytic subunit" 2.7.7.7 DNA Polymerase B subunit 2 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere;The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin;DNA polymerase alpha:primase binds at the origin;DNA polymerase epsilon binds at the origin" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" "a 2'-deoxyribonucleoside 5'-triphosphate + DNAn => diphosphate + DNAn+1;diphosphate + DNAn+1 => a 2'-deoxyribonucleoside 5'-triphosphate + DNAn" "Deoxynucleoside triphosphate + DNA(n) <=> Diphosphate + DNA(n+1);dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA;2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate <=> DNA 5-hydroxymethylcytosine;dCTP + DNAn = diphosphate + DNAn+1;deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1;a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1" a 2'-deoxyribonucleoside 5'-triphosphate + (deoxynucleotides)(n) => (deoxynucleotides)(n+1) + diphosphate "dATP + DNA <=> Diphosphate + DNA;dGTP + DNA <=> Diphosphate + DNA;dCTP + DNA <=> Diphosphate + DNA;dTTP + DNA <=> Diphosphate + DNA" 5 out of 5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 0.0036 dAMP [cytoplasm] + 0.0024 dCMP [cytoplasm] + 0.0024 dGMP [cytoplasm] + 0.0036 dTMP [cytoplasm] => DNA [cytoplasm] YES DNA replication "DNA synthesis; pathway from kegg" H1117 "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair" "Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex" "Purine metabolism;path:map00230;Pyrimidine metabolism;path:map00240;Metabolic pathways;path:map01100" "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +909 YPR187W "RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit" RNA polymerase subunit ABC23 DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds. {ECO:0000269|PubMed:18160037, ECO:0000269|PubMed:24153182, ECO:0000269|PubMed:24153184}. DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (ABC23) (DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide) "RPO26, RPB6; DNA-directed RNA polymerase core subunit RPO26" RNA POlymerase "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex;Formation of the closed pre-initiation complex;Addition of nucleotides between position +11 and +30;RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;Hypophosphorylation of RNA Pol II CTD by FCP1P protein;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA;DSIF complex binds to RNA Pol II (hypophosphorylated);Abortive termination of early transcription elongation by DSIF:NELF;Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex;RNA Pol II initiates transcription from damaged DNA template;Active RNA Pol II complex transcribes lesion-containing DNA template;ERCC6 binds stalled RNA Pol II;ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II;UVSSA:USP7 deubiquitinates ERCC6;RNA Pol II backtracking in TC-NER;Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER;5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER;Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER;DNA polymerases delta, epsilon or kappa bind the TC-NER site;3' incision by ERCC5 (XPG) in TC-NER;Ligation of newly synthesized repair patch to incised DNA in TC-NER;CDK12 phosphorylates RNA Pol II CTD at DNA repair genes;CCNK:CDK12 binds RNA Pol II at DNA repair genes;Binding of RRN3 to RNA Polymerase I;Formation of AT-AC C complex;ATAC spliceosome mediated Lariat formation,5' splice site cleavage;Addition of the third nucleotide on the nascent transcript;NTP Binds Active Site of RNA Polymerase II;Fall Back to Closed Pre-initiation Complex;Newly Formed Phosphodiester Bond Stabilized and PPi Released;Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP;Addition of the fourth nucleotide on the Nascent Transcript: Second Transition;RNA Polymerase II Promoter Opening: First Transition;Addition of nucleotides 10 and 11 on the growing transcript: Third Transition;Activation of GT;Phosphorylation (Ser5) of RNA pol II CTD;SPT5 subunit of Pol II binds the RNA triphosphatase (RTP);Capping complex formation;Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme;Formation of the CE:GMP intermediate complex;Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA;Dissociation of transcript with 5'-GMP from GT;Recognition and binding of the mRNA cap by the cap-binding complex" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" "Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;mRNA Capping;mRNA Splicing - Minor Pathway;RNA Polymerase I Transcription Initiation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE" NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +910 YPR190C RNA polymerase III subunit C82 RNA polymerase III subunit C82 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (C82) (DNA-directed III 74 kDa polypeptide) (C74) "RPC82, RPC3, RPC80; DNA-directed RNA polymerase III subunit C82" RNA Polymerase C "RNA Polymerase III Promoter Opening;RNA Polymerase III Initiation At a Simple Start Sequence;RNA Polymerase III Abortive Initiation;Beginning of RNA Polymerase III Productive Transcription;RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites;RNA Polymerase III Transcriptional Pause at Terminator Sequence;RNA Polymerase III Termination and release of transcribed RNA" a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate "ATP + RNA <=> Diphosphate + RNA;GTP + RNA <=> Diphosphate + RNA;CTP + RNA <=> Diphosphate + RNA;UTP + RNA <=> Diphosphate + RNA" 5 out of 5 NA 0.046 AMP [cytoplasm] + 0.0447 CMP [cytoplasm] + 0.046 GMP [cytoplasm] + 0.0599 UMP [cytoplasm] => RNA [cytoplasm] YES RNA polymerase pathway from kegg "Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase" NA "cytoplasm;nucleus" "nucleus;cytoplasm" "nucleus;cytoplasm" +916 YLL018C-A "Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs" NA Protein required for cytochrome c oxidase assembly Required for the assembly of mitochondrial cytochrome c oxidase. {ECO:0000269|PubMed:12171940}. NA Cytochrome c oxidase assembly protein COX19 "COX19; Cox19p" NA Cytochrome c OXidase "MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds;MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds" NA NA NA NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] NA NA 4 out of 5 NA 4 a reduced c-type cytochrome[out] + oxygen[in] + 8 H+[in] => 4 an oxidized c-type cytochrome[out] + 4 H+[out] + 2 H2O[in] YES Oxidative phosphorylation pathway from kegg NA NA NA NA aerobic respiration (cytochrome c) // aerobic respiration (linear view) NA NA "cytoplasm;mitochondrial membrane" "cytoplasm;mitochondrion;mitochondrial membrane" "mitochondrial membrane;cytoplasm" +918 YOL077W-A "Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase" Subunit k of the mitochondrial F1F0 ATP synthase Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. The K chain binds the dimeric form by interacting with the G and E chains. ATP synthase subunit K, mitochondrial "ATP19; F1F0 ATP synthase subunit K" ATP synthase ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] 4 out of 5 NA ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] YES Oxidative phosphorylation pathway from kegg "Oxidative phosphorylation;Metabolic pathways" superpathway of purine nucleotides de novo biosynthesis I // adenosine nucleotides de novo biosynthesis // adenosine ribonucleotides de novo biosynthesis NA mitochondrial membrane "mitochondrion;mitochondrial membrane" mitochondrial membrane +921 YPL096C-A "Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein" Endoplasmic reticulum membrane protein that binds and inhibits Ras2p Probable component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. Ras may inhibit the enzyme activity of the GPI-GnT complex via the association between ERI1 and RAS2. {ECO:0000269|PubMed:12832483, ECO:0000269|PubMed:15163411}. Phosphatidylinositol N-acetylglucosaminyltransferase ERI1 subunit (GPI-GlcNAc transferase complex subunit ERI1) (GPI-GnT subunit ERI1) (Endoplasmic reticulum-associated Ras inhibitor protein 1) "ERI1, RIN1; Eri1p" ER-associated Ras Inhibitor UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 4 out of 5 NA UDP-N-acetyl-D-glucosamine + 1-Phosphatidyl-D-myo-inositol <=> UDP + G00143 YES Glycosylphosphatidylinositol (GPI)-anchor biosynthesis "atalyzes the first step in GPI-anchor biosynthesis; pathway from kegg" "PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000305|PubMed:12832483}." "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways" NA endoplasmic reticulum membrane "endoplasmic reticulum;endoplasmic reticulum membrane" endoplasmic reticulum membrane 922 YCL005W-A "Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis" Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex Subunit of the integral membrane V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO:0000269|PubMed:14594803}. V-type proton ATPase subunit e (V-ATPase subunit e) (Low dye-binding protein 10) (Vacuolar proton pump subunit e) "VMA9, CWH36, LDB10; H(+)-transporting V0 sector ATPase subunit E" Vacuolar Membrane Atpase ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] 5 out of 5 NA ADP + phosphate + 4 H+[out] <=> ATP + H2O + 3 H+[in] YES Oxidative phosphorylation pathway from kegg superpathway of purine nucleotides de novo biosynthesis I // adenosine nucleotides de novo biosynthesis // adenosine ribonucleotides de novo biosynthesis NA vacuolar membrane "vacuolar membrane;vacuole" vacuolar membrane \ No newline at end of file diff --git a/ComplementaryData/databases/TransRxnGeneAnnotation.tsv b/ComplementaryData/databases/TransRxnGeneAnnotation.tsv index 7ee3ed02..58ae9b5f 100644 --- a/ComplementaryData/databases/TransRxnGeneAnnotation.tsv +++ b/ComplementaryData/databases/TransRxnGeneAnnotation.tsv @@ -1,178 +1,178 @@ -gene rxnID formula annotation_uniprot main_met_mnx other_met annotation_SGD ec_SGD protein_name_SGD ec_uniprot protein_name_uniprot Annotation_score reaction_uniprot annotation_kegg ec_kegg annotation_biocyc annotation_reactome TC_number annotation_TCDB subunit -YGL077C r_1149 ethanolamine[e] <=> ethanolamine[c] Sole choline transporter in yeast. MNXM218 none "Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol" NA Plasma membrane transporter for choline, ethanolamine, and carnitine NA Choline transport protein 5 out of 5 NA "HNM1, CTR1; Hnm1p" NA Hyper-resistance to Nitrogen Mustard NA 2.A.3.4.1 Choline transport protein - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJL133W r_1179 iron(2+)[c] => iron(2+)[m] MRS3 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). MNXM111 none "Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication" NA Iron transporter, mediates Fe2+ transport across inner mito membrane NA Mitochondrial RNA-splicing protein MRS3 4 out of 5 NA "MRS3; Fe(2+) transporter" NA Mitochondrial RNA Splicing MRS3/4 Transports Iron Across the Mitochondrial Inner Membrane 2.A.29.5.1 Mitochondrial RNA-splicing protein MRS3 OS=Saccharomyces cerevisiae GN=MRS3 PE=1 SV=4 FALSE -YKR052C r_1179 iron(2+)[c] => iron(2+)[m] MRS4 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). Not essential. MNXM111 none "Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication" NA Iron transporter of the mitochondrial carrier family NA Mitochondrial RNA-splicing protein MRS4 4 out of 5 NA "MRS4; Fe(2+) transporter" NA Mitochondrial RNA Splicing MRS3/4 Transports Iron Across the Mitochondrial Inner Membrane 2.A.29.5.2 Mitochondrial RNA splicing protein MRS4 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKL188C r_1236 stearate[c] <=> stearate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM236 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE -YPL147W r_1236 stearate[c] <=> stearate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM236 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE -YKL120W r_1574 2-isopropylmalate[c] <=> 2-isopropylmalate[m] Transports oxaloacetate and sulfate. MNXM164143 none "Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family" NA Mitochondrial inner membrane transporter NA Mitochondrial oxaloacetate transport protein (Mitochondrial carrier protein PMT) 5 out of 5 NA "OAC1; Oac1p" NA OxaloAcetate Carrier NA 2.A.29.15.1 MITOCHONDRIAL CARRIER PROTEIN PMT - Saccharomyces cerevisiae (Baker's yeast). FALSE -YPR011C r_1642 adenosine 3',5'-bismonophosphate[c] <=> adenosine 3',5'-bismonophosphate[m] NA MNXM45 none "Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" NA Mitochondrial transporter NA Uncharacterized mitochondrial carrier YPR011C 3 out of 5 NA hypothetical protein NA YPR011C NA 2.A.29.23.9 Uncharacterized mitochondrial carrier YPR011C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPR011C PE=1 SV=1 FALSE -YBR147W r_1657 H+[c] + L-arginine[c] => H+[m] + L-arginine[m] May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. MNXM70 h+ "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" NA Putative vacuolar membrane transporter for cationic amino acids NA Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) 4 out of 5 NA "RTC2, RRT11, YPQ3; cationic amino acid transporter" NA Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 2.A.43.2.7 Protein RTC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTC2 PE=1 SV=1 FALSE -YDR508C r_1658 L-asparagine[c] => L-asparagine[m] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM147 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YGL077C r_1684 choline[ce] <=> choline[c] Sole choline transporter in yeast. MNXM90 none "Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol" NA Plasma membrane transporter for choline, ethanolamine, and carnitine NA Choline transport protein 5 out of 5 NA "HNM1, CTR1; Hnm1p" NA Hyper-resistance to Nitrogen Mustard NA 2.A.3.4.1 Choline transport protein - Saccharomyces cerevisiae (Baker's yeast). FALSE -YOR161C r_1684 choline[ce] <=> choline[c] Probably involved in transport through the plasma membrane. {ECO:0000250}. MNXM90 none "Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport" NA Protein of unknown function NA Protein PNS1 (pH nine-sensitive protein 1) 2 out of 5 NA "PNS1; Pns1p" NA pH Nine Sensitive "Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;SLC44A1 transports Cho from cytosol to mitochondrial matrix;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.92.1.8 Protein PNS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNS1 PE=1 SV=1 FALSE -YDR342C r_1707 D-arabinose[e] <=> D-arabinose[c] High-affinity glucose transporter. MNXM48397 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE -YHR092C r_1707 D-arabinose[e] <=> D-arabinose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM48397 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YDL245C r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE -YEL069C r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE -YJR158W r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE -YNR072W r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE -YHR092C r_1719 D-xylose[e] <=> D-xylose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM90941 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YBL042C r_1735 2'-deoxyuridine[e] => 2'-deoxyuridine[c] High-affinity transport of uridine. MNXM492 none "High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress" NA High affinity uridine permease, localizes to the plasma membrane NA Uridine permease 4 out of 5 NA "FUI1; uridine permease" NA 5-FlUorourIdine resistance NA 2.A.39.3.3 URIDINE PERMEASE - Saccharomyces cerevisiae (Baker's yeast). FALSE -YIL013C r_1760 ergosterol[c] <=> ergosterol[ce] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM922 none "ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication" NA ATP-binding cassette (ABC) transporter NA ATP-dependent permease PDR11 4 out of 5 NA "PDR11; ATP-binding cassette multidrug transporter PDR11" NA Pleiotropic Drug Resistance NA 3.A.1.205.8 ATP-dependent permease PDR11 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YOR011W r_1760 ergosterol[c] <=> ergosterol[ce] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM922 none "Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication" NA Plasma membrane sterol transporter of the ATP-binding cassette family NA ATP-dependent permease AUS1 3 out of 5 NA "AUS1; ATP-binding cassette sterol transporter AUS1" NA ABC protein involved in Uptake of Sterols NA 3.A.1.205.15 ATP-dependent permease AUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AUS1 PE=1 SV=1 FALSE -YKL188C r_1771 laurate[c] <=> laurate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM402 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE -YPL147W r_1771 laurate[c] <=> laurate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM402 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE -YKL188C r_1772 myristate[c] <=> myristate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM314 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE -YPL147W r_1772 myristate[c] <=> myristate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM314 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE -YKL188C r_1774 palmitate[c] <=> palmitate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM108 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE -YPL147W r_1774 palmitate[c] <=> palmitate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM108 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE -YNL065W r_1795 formate[e] <=> formate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM39 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YGL225W r_1803 GDP-alpha-D-mannose[c] <=> GDP-alpha-D-mannose[g] Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity. {ECO:0000269|PubMed:10570930, ECO:0000269|PubMed:11067855, ECO:0000269|PubMed:12478588, ECO:0000269|PubMed:15494368, ECO:0000269|PubMed:2014241, ECO:0000269|PubMed:2137555, ECO:0000269|PubMed:7672592, ECO:0000269|PubMed:7877969, ECO:0000269|PubMed:8632002, ECO:0000269|PubMed:9184829, ECO:0000269|PubMed:9335583, ECO:0000269|PubMed:9395539}. MNXM82 none "Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication" NA Golgi GDP-mannose transporter NA GDP-mannose transporter 1 (GMT 1) (Low dye-binding protein 3) (Morphogenesis checkpoint-dependent protein 3) (Vanadate resistance glycosylation protein 4) 5 out of 5 NA "VRG4, GOG5, LDB3, VAN2, VIG4; GDP-mannose transporter" NA Vandate Resistance Glycosylation NA 2.A.7.13.1 Vanadate resistance protein GOG5/VRG4/VAN2 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YPR058W r_1811 L-glycine[c] <=> L-glycine[m] NA MNXM29 none "Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication" NA Secondary mitochondrial inner membrane glycine transporter NA Carrier protein YMC1, mitochondrial 3 out of 5 NA "YMC1; organic acid transporter" NA Yeast Mitochondrial Carrier NA 2.A.29.8.12 Carrier protein YMC1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YMC1 PE=1 SV=2 FALSE -YNL065W r_1816 glyoxylate[c] <=> glyoxylate[e] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM69 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YBR147W r_1837 L-histidine[c] => L-histidine[m] May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. MNXM134 none "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" NA Putative vacuolar membrane transporter for cationic amino acids NA Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) 4 out of 5 NA "RTC2, RRT11, YPQ3; cationic amino acid transporter" NA Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 2.A.43.2.7 Protein RTC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTC2 PE=1 SV=1 FALSE -YDR342C r_1877 L-arabinose[e] <=> L-arabinose[c] High-affinity glucose transporter. MNXM461 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE -YHR092C r_1877 L-arabinose[e] <=> L-arabinose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM461 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YOR100C r_1882 (R)-carnitine[m] => (R)-carnitine[c] Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines. {ECO:0000269|PubMed:10545096, ECO:0000269|PubMed:10622748}. MNXM173 none "Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant" NA Mitochondrial inner membrane carnitine transporter NA Mitochondrial carnitine carrier 3 out of 5 NA "CRC1; carnitine:acyl carnitine antiporter" NA CaRnitine Carrier "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane;SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix" 2.A.29.8.4 Mitochondrial carnitine carrier - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR039W r_1907 L-serine[c] <=> L-serine[er] General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449). {ECO:0000269|PubMed:10373490, ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10953083, ECO:0000269|PubMed:14968425, ECO:0000269|PubMed:15707981, ECO:0000269|PubMed:21471002, ECO:0000269|PubMed:22844449, ECO:0000269|PubMed:5474888}. MNXM53 none "General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth" NA General amino acid permease NA General amino-acid permease GAP1 5 out of 5 NA "GAP1; amino acid permease GAP1" NA General Amino acid Permease NA 2.A.3.10.2 General amino-acid permease GAP1 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YDL245C r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE -YEL069C r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE -YJR158W r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE -YNR072W r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE -YDL245C r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE -YDR342C r_1910 L-sorbose[e] <=> L-sorbose[c] High-affinity glucose transporter. MNXM588 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE -YDR343C r_1910 L-sorbose[e] <=> L-sorbose[c] High-affinity glucose transporter. MNXM588 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT6 4 out of 5 NA "HXT6; hexose transporter HXT6" NA HeXose Transporter NA NA NA FALSE -YDR345C r_1910 L-sorbose[e] <=> L-sorbose[c] Low-affinity glucose transporter. MNXM588 none "Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication" NA Low affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT3 5 out of 5 NA "HXT3; hexose transporter HXT3" NA HeXose Transporter NA NA NA FALSE -YEL069C r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE -YFL011W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative hexose transporter; expressed at low levels and expression is repressed by glucose" NA Putative hexose transporter NA Hexose transporter HXT10 4 out of 5 NA "HXT10; hexose transporter HXT10" NA HeXose Transporter NA 2.A.1.1.5 Hexose transporter HXT10 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YHR092C r_1910 L-sorbose[e] <=> L-sorbose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM588 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YHR094C r_1910 L-sorbose[e] <=> L-sorbose[c] Low-affinity glucose transporter. HXT1 is as well involved in the transport of mannose. MNXM588 none "Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication" NA Low-affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT1 5 out of 5 NA "HXT1, HOR4; hexose transporter HXT1" NA HeXose Transporter NA 2.A.1.1.108 Low-affinity glucose transporter HXT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT1 PE=1 SV=1 FALSE -YHR096C r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication" NA Hexose transporter with moderate affinity for glucose NA Probable glucose transporter HXT5 4 out of 5 NA "HXT5; hexose transporter HXT5" NA HeXose Transporter NA NA NA FALSE -YJL214W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Protein of unknown function with similarity to hexose transporters NA Hexose transporter HXT8 4 out of 5 NA "HXT8; hexose transporter HXT8" NA HeXose Transporter NA NA NA FALSE -YJL219W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p" NA Putative hexose transporter that is nearly identical to Hxt11p NA Hexose transporter HXT9 4 out of 5 NA "HXT9; hexose transporter HXT9" NA HeXose Transporter NA NA NA FALSE -YJR158W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE -YMR011W r_1910 L-sorbose[e] <=> L-sorbose[c] High-affinity glucose transporter. Is only indispensable for growth on low glucose-containing media, because S.cerevisiae possesses other sugar transporters. MNXM588 none "High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose" NA High-affinity glucose transporter of the major facilitator superfamily NA High-affinity glucose transporter HXT2 4 out of 5 NA "HXT2; hexose transporter HXT2" NA HeXose Transporter NA 2.A.1.1.111 High-affinity glucose transporter HXT2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT2 PE=1 SV=1 FALSE -YNR072W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE -YOL156W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance" NA Hexose transporter NA Hexose transporter HXT11 (Low-affinity glucose transporter LGT3) 4 out of 5 NA "HXT11, LGT3; hexose transporter HXT11" NA HeXose Transporter NA 2.A.1.1.105 Hexose transporter HXT11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT11 PE=1 SV=1 FALSE -YBR147W r_1919 L-lysine[c] => L-lysine[m] May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. MNXM78 none "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" NA Putative vacuolar membrane transporter for cationic amino acids NA Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) 4 out of 5 NA "RTC2, RRT11, YPQ3; cationic amino acid transporter" NA Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 2.A.43.2.7 Protein RTC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTC2 PE=1 SV=1 FALSE -YDR508C r_1935 L-methionine[m] => L-methionine[c] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM61 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YOR100C r_1976 O-acetylcarnitine[c] => O-acetylcarnitine[m] Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines. {ECO:0000269|PubMed:10545096, ECO:0000269|PubMed:10622748}. MNXM1028 none "Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant" NA Mitochondrial inner membrane carnitine transporter NA Mitochondrial carnitine carrier 3 out of 5 NA "CRC1; carnitine:acyl carnitine antiporter" NA CaRnitine Carrier "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane;SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix" 2.A.29.8.4 Mitochondrial carnitine carrier - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJL212C r_1990 glutathione disulfide[e] => glutathione disulfide[c] High affinity transporter for glutathione. Also transports tetra- and pentapeptides like the opioids leucine enkephalin (Tyr-Gly-Gly-Phe-Leu) and methionine enkephalin (Tyr-Gly-Gly_Phe-Met) across the cell membrane. {ECO:0000269|PubMed:10652283, ECO:0000269|PubMed:10788431}. MNXM151 none "Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family" NA Proton-coupled oligopeptide transporter of the plasma membrane NA Oligopeptide transporter 1 (High affinity glutathione transporter 1) 4 out of 5 NA "OPT1, GSH11, HGT1; oligopeptide transporter OPT1" NA OligoPeptide Transporter NA 2.A.67.1.3 HYPOTHETICAL 91.6 KDA PROTEIN IN HXT8-CRT1 INTERGENIC REGION - Saccharomyces cerevisiae (Baker's yeast). FALSE -YNR013C r_2008 phosphate[c] <=> phosphate[v] Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol. {ECO:0000269|PubMed:11779791, ECO:0000269|PubMed:17804816, ECO:0000269|PubMed:20133652}. MNXM9 none "Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth" NA Low-affinity vacuolar phosphate transporter NA Low-affinity phosphate transporter PHO91 5 out of 5 NA "PHO91; Pho91p" NA PHOsphate metabolism NA 2.A.47.2.2 Uncharacterized transporter YNR013C - Saccharomyces cerevisiae (Baker's yeast). FALSE -YOR306C r_2040 riboflavin[e] => riboflavin[c] Riboflavin transporter involved in riboflavin (vitamin B2) uptake. Does not act in the transport of monocarboxylic acids across the plasma membrane. {ECO:0000269|PubMed:16204239}. MNXM270 none "Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport" NA Plasma membrane riboflavin transporter NA Riboflavin transporter MCH5 3 out of 5 NA "MCH5; Mch5p" NA MonoCarboxylate transporter Homologue NA 2.A.1.13.4 S.cerevisiae chromosome XV reading frame ORF YOR306c - Saccharomyces cerevisiae (Baker's yeast). FALSE -YDR342C r_2041 D-ribose[e] => D-ribose[c] High-affinity glucose transporter. MNXM242 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE -YHR092C r_2041 D-ribose[e] => D-ribose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM242 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YDR508C r_2045 L-serine[c] <=> L-serine[m] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM53 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YDR508C r_2072 L-threonine[c] => L-threonine[m] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM142 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YLL052C r_2094 H2O[c] <=> H2O[er] Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains. {ECO:0000250}. MNXM2 none "Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" NA Water channel that mediates water transport across cell membranes NA Aquaporin-like protein 2 (Truncated aquaporin-2) 4 out of 5 NA "AQY2; Aqy2p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE -YPR192W r_2094 H2O[c] <=> H2O[er] Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains. {ECO:0000250, ECO:0000269|PubMed:10092523, ECO:0000269|PubMed:10870101, ECO:0000269|PubMed:9765289}. MNXM2 none "Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" NA Spore-specific water channel NA Aquaporin-1 5 out of 5 NA "AQY1; Aqy1p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE -YDL245C r_2105 xylitol[e] <=> xylitol[c] Probable glucose transporter. MNXM510 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE -YLL043W r_2105 xylitol[e] <=> xylitol[c] Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation: under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions. MNXM510 none "Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state" NA Aquaglyceroporin, plasma membrane channel NA Glycerol uptake/efflux facilitator protein 5 out of 5 NA "FPS1; Fps1p" NA fdp1 Suppressor NA 1.A.8.5.1 GLYCEROL UPTAKE/EFFLUX FACILITATOR PROTEIN - Saccharomyces cerevisiae (Baker's yeast). FALSE -YIL013C r_2107 zymosterol[ce] <=> zymosterol[c] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM574 none "ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication" NA ATP-binding cassette (ABC) transporter NA ATP-dependent permease PDR11 4 out of 5 NA "PDR11; ATP-binding cassette multidrug transporter PDR11" NA Pleiotropic Drug Resistance NA 3.A.1.205.8 ATP-dependent permease PDR11 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YOR011W r_2107 zymosterol[ce] <=> zymosterol[c] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM574 none "Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication" NA Plasma membrane sterol transporter of the ATP-binding cassette family NA ATP-dependent permease AUS1 3 out of 5 NA "AUS1; ATP-binding cassette sterol transporter AUS1" NA ABC protein involved in Uptake of Sterols NA 3.A.1.205.15 ATP-dependent permease AUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AUS1 PE=1 SV=1 FALSE -YNL065W r_2190 butyrate[e] <=> butyrate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM458 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YNL065W r_2191 hexanoate[e] <=> hexanoate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM1653 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKL188C r_2231 oleate[c] <=> oleate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM306 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE -YPL147W r_2231 oleate[c] <=> oleate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM306 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE -YLL052C r_3526 H2O[c] <=> H2O[erm] Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains. {ECO:0000250}. MNXM2 none "Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" NA Water channel that mediates water transport across cell membranes NA Aquaporin-like protein 2 (Truncated aquaporin-2) 4 out of 5 NA "AQY2; Aqy2p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE -YPR192W r_3526 H2O[c] <=> H2O[erm] Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains. {ECO:0000250, ECO:0000269|PubMed:10092523, ECO:0000269|PubMed:10870101, ECO:0000269|PubMed:9765289}. MNXM2 none "Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" NA Spore-specific water channel NA Aquaporin-1 5 out of 5 NA "AQY1; Aqy1p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE -YKR039W r_3545 L-serine[c] <=> L-serine[erm] General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449). {ECO:0000269|PubMed:10373490, ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10953083, ECO:0000269|PubMed:14968425, ECO:0000269|PubMed:15707981, ECO:0000269|PubMed:21471002, ECO:0000269|PubMed:22844449, ECO:0000269|PubMed:5474888}. MNXM53 none "General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth" NA General amino acid permease NA General amino-acid permease GAP1 5 out of 5 NA "GAP1; amino acid permease GAP1" NA General Amino acid Permease NA 2.A.3.10.2 General amino-acid permease GAP1 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YLL052C r_3604 H2O[c] <=> H2O[ce] Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains. {ECO:0000250}. MNXM2 none "Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" NA Water channel that mediates water transport across cell membranes NA Aquaporin-like protein 2 (Truncated aquaporin-2) 4 out of 5 NA "AQY2; Aqy2p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE -YLL053C r_3604 H2O[c] <=> H2O[ce] NA MNXM2 none "Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin" NA Putative protein NA Putative uncharacterized protein YLL053C 2 out of 5 NA hypothetical protein NA YLL053C "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE -YPR192W r_3604 H2O[c] <=> H2O[ce] Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains. {ECO:0000250, ECO:0000269|PubMed:10092523, ECO:0000269|PubMed:10870101, ECO:0000269|PubMed:9765289}. MNXM2 none "Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" NA Spore-specific water channel NA Aquaporin-1 5 out of 5 NA "AQY1; Aqy1p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE -YCR037C r_3605 phosphate[c] <=> phosphate[ce] Involved in the uptake of inorganic phosphate. MNXM9 none "Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of the PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication" NA Low-affinity inorganic phosphate (Pi) transporter NA Inorganic phosphate transporter PHO87 4 out of 5 NA "PHO87; SPX domain-containing inorganic phosphate transporter" NA PHOsphate metabolism NA 2.A.47.2.1 INORGANIC PHOSPHATE TRANSPORTER PHO87 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJL198W r_3605 phosphate[c] <=> phosphate[ce] Low-affinity phosphate transporter involved in the control of cellular phosphate levels. {ECO:0000269|PubMed:11779791, ECO:0000269|PubMed:20133652}. MNXM9 none "Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication" NA Low-affinity phosphate transporter NA Low-affinity phosphate transporter PHO90 4 out of 5 NA "PHO90; SPX domain-containing inorganic phosphate transporter" NA PHOsphate metabolism NA 2.A.47.2.3 Low-affinity phosphate transporter PHO90 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHO90 PE=1 SV=1 FALSE -YML123C r_3605 phosphate[c] <=> phosphate[ce] High-affinity transporter for external inorganic phosphate. Is not an essential protein, since a constitutive, low affinity pI transporter exists in yeast. MNXM9 none "High-affinity inorganic phosphate (Pi) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity" NA High-affinity inorganic phosphate (Pi) transporter NA Inorganic phosphate transporter PHO84 5 out of 5 NA "PHO84; phosphate transporter PHO84" NA PHOsphate metabolism NA 2.A.1.9.1 Inorganic phosphate transporter PHO84 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YCR098C r_3606 sn-glycero-3-phosphocholine[ce] <=> sn-glycero-3-phosphocholine[c] Glycerophosphodiester transporter that mediates uptake of both glycerophosphoinositol (GroPIns) and glycerophosphocholine (GroPCho) as sources of the nutrients inositol and phosphate (PubMed:9691030, PubMed:12912892, PubMed:16141200). {ECO:0000269|PubMed:12912892, ECO:0000269|PubMed:16141200, ECO:0000269|PubMed:9691030}. MNXM367 none "Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability" NA Plasma membrane permease NA Glycerophosphoinositol transporter 1 4 out of 5 NA "GIT1; Git1p" NA GlycerophosphoInosiTol NA 2.A.1.9.7 Probable metabolite transport protein GIT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GIT1 PE=1 SV=1 FALSE -YCR098C r_3607 1-(sn-glycero-3-phospho)-1D-myo-inositol[ce] <=> 1-(sn-glycero-3-phospho)-1D-myo-inositol[c] Glycerophosphodiester transporter that mediates uptake of both glycerophosphoinositol (GroPIns) and glycerophosphocholine (GroPCho) as sources of the nutrients inositol and phosphate (PubMed:9691030, PubMed:12912892, PubMed:16141200). {ECO:0000269|PubMed:12912892, ECO:0000269|PubMed:16141200, ECO:0000269|PubMed:9691030}. MNXM1517 none "Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability" NA Plasma membrane permease NA Glycerophosphoinositol transporter 1 4 out of 5 NA "GIT1; Git1p" NA GlycerophosphoInosiTol NA 2.A.1.9.7 Probable metabolite transport protein GIT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GIT1 PE=1 SV=1 FALSE -YNR013C r_3649 phosphate[c] <=> phosphate[vm] Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol. {ECO:0000269|PubMed:11779791, ECO:0000269|PubMed:17804816, ECO:0000269|PubMed:20133652}. MNXM9 none "Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth" NA Low-affinity vacuolar phosphate transporter NA Low-affinity phosphate transporter PHO91 5 out of 5 NA "PHO91; Pho91p" NA PHOsphate metabolism NA 2.A.47.2.2 Uncharacterized transporter YNR013C - Saccharomyces cerevisiae (Baker's yeast). FALSE -YHR002W r_3680 coenzyme A[mm] <=> coenzyme A[c] Required for the accumulation of coenzyme A in the mitochondrial matrix. {ECO:0000269|PubMed:11158296}. MNXM12 none "Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized" NA Mitochondrial carrier protein NA Mitochondrial carrier protein LEU5 3 out of 5 NA "LEU5; coenzyme A transporter" NA LEUcine biosynthesis SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix 2.A.29.12.4 Mitochondrial carrier protein LEU5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LEU5 PE=2 SV=1 FALSE -YIL048W r_3813 phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78605 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YMR162C r_3813 phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78605 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE -YIL048W r_3814 phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. NA none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YMR162C r_3814 phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. NA none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE -YIL048W r_3815 phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78765 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YMR162C r_3815 phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78765 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE -YIL048W r_3816 phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78797 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YMR162C r_3816 phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78797 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE -YIL048W r_3817 phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680894 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YMR162C r_3817 phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM680894 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE -YIL048W r_3818 phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78642 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YMR162C r_3818 phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78642 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE -YIL048W r_3819 phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680500 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YMR162C r_3819 phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM680500 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE -YIL048W r_3820 phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM32173 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YMR162C r_3820 phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM32173 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE -YAL026C r_3821 phosphatidylethanolamine (1-16:0, 2-16:1)[gm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588855 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3822 phosphatidylethanolamine (1-16:1, 2-16:1)[gm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. NA none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3823 phosphatidylethanolamine (1-18:0, 2-16:1)[gm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588866 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3824 phosphatidylethanolamine (1-18:1, 2-16:1)[gm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM71684 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3825 phosphatidylethanolamine (1-16:0, 2-18:1)[gm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588857 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3826 phosphatidylethanolamine (1-16:1, 2-18:1)[gm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM611809 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3827 phosphatidylethanolamine (1-18:0, 2-18:1)[gm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588872 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3828 phosphatidylethanolamine (1-18:1, 2-18:1)[gm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588883 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3885 phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588855 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3886 phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. NA none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3887 phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588866 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3888 phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM71684 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3889 phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588857 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3890 phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM611809 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3891 phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588872 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YAL026C r_3892 phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588883 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YIL048W r_3893 phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78605 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YIL048W r_3894 phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. NA none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YIL048W r_3895 phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78765 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YIL048W r_3896 phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78797 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YIL048W r_3897 phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680894 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YIL048W r_3898 phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78642 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YIL048W r_3899 phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680500 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YIL048W r_3900 phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM32173 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE -YBR192W r_3959 CMP[m] <=> CMP[mm] NA MNXM31 none "Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family" NA Mitochondrial pyrimidine nucleotide transporter NA Mitochondrial carrier protein RIM2 4 out of 5 NA "RIM2, PYT1; Rim2p" NA Replication In Mitochondria NA 2.A.29.10.4 2.A.29.10.4 Mitochondrial carrier protein RIM2 FALSE -YBR192W r_3960 CTP[m] <=> CTP[mm] NA MNXM63 none "Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family" NA Mitochondrial pyrimidine nucleotide transporter NA Mitochondrial carrier protein RIM2 4 out of 5 NA "RIM2, PYT1; Rim2p" NA Replication In Mitochondria NA 2.A.29.10.4 2.A.29.10.4 Mitochondrial carrier protein RIM2 FALSE -YER053C r_3961 phosphate[m] <=> phosphate[mm] Transport of phosphate groups from the cytosol to the mitochondrial matrix. {ECO:0000269|PubMed:11328608, ECO:0000269|PubMed:14756774}. MNXM9 none "Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature" NA Mitochondrial copper and phosphate carrier NA Mitochondrial phosphate carrier protein 2 (Phosphate transport protein 2) (PTP 2) (Pi carrier isoform 2) (mPic 2) 5 out of 5 NA "PIC2; Cu/Pi carrier" NA PI Carrier NA 2.A.29.4.4 Mitochondrial phosphate carrier protein 2 OS=Saccharomyces cerevisiae GN=PIC2 PE=1 SV=1 FALSE -YJR077C r_3961 phosphate[m] <=> phosphate[mm] Transport of phosphate groups from the cytosol to the mitochondrial matrix. MNXM9 none "Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated" NA Mitochondrial phosphate carrier NA Mitochondrial phosphate carrier protein (Mitochondrial import receptor) (Phosphate transport protein) (PTP) (mPic 1) (p32) [Cleaved into: Mitochondrial phosphate carrier protein, N-terminally processed] 5 out of 5 NA "MIR1; Mir1p" NA MIR1 "TIM22 complex inserts proteins into inner membrane;TIM22 complex inserts proteins into inner membrane" 2.A.29.4.3 Mitochondrial phosphate carrier protein OS=Saccharomyces cerevisiae GN=MIR1 PE=1 SV=1 FALSE -YLR348C r_3961 phosphate[m] <=> phosphate[mm] Mitochondrial dicarboxylic transporter catalyzing the exchange of dicarboxylic acids like malate and succinate for inorganic phosphate. Required for growth on ethanol and acetate. {ECO:0000269|PubMed:10027973, ECO:0000269|PubMed:8831951, ECO:0000269|PubMed:9020177, ECO:0000269|PubMed:9559855}. MNXM9 none "Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix" NA Mitochondrial dicarboxylate carrier NA Mitochondrial dicarboxylate transporter (DTP) (Dicarboxylate carrier 1) 5 out of 5 NA "DIC1; Dic1p" NA DIcarboxylate Carrier "Sulfate is exported to the cytosol in exchange for dicarboxylate;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix];malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix];Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane" 2.A.29.2.3 BELONGS TO THE MITOCHONDRIAL CARRIER FAMILY - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4361 H+[e] + Gly-Met[e] <=> H+[c] + Gly-Met[c] Component of the allantoate transport system. MNXM55287 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4361 H+[e] + Gly-Met[e] <=> H+[c] + Gly-Met[c] Uptake of small peptides. MNXM55287 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4387 H+[e] + Ala-Asp[e] <=> H+[c] + Ala-Asp[c] Component of the allantoate transport system. MNXM40494 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4387 H+[e] + Ala-Asp[e] <=> H+[c] + Ala-Asp[c] Uptake of small peptides. MNXM40494 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YDL245C r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE -YDR342C r_4395 D-tagatose[e] <=> D-tagatose[c] High-affinity glucose transporter. MNXM92401 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE -YDR343C r_4395 D-tagatose[e] <=> D-tagatose[c] High-affinity glucose transporter. MNXM92401 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT6 4 out of 5 NA "HXT6; hexose transporter HXT6" NA HeXose Transporter NA NA NA FALSE -YDR345C r_4395 D-tagatose[e] <=> D-tagatose[c] Low-affinity glucose transporter. MNXM92401 none "Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication" NA Low affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT3 5 out of 5 NA "HXT3; hexose transporter HXT3" NA HeXose Transporter NA NA NA FALSE -YEL069C r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE -YFL011W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative hexose transporter; expressed at low levels and expression is repressed by glucose" NA Putative hexose transporter NA Hexose transporter HXT10 4 out of 5 NA "HXT10; hexose transporter HXT10" NA HeXose Transporter NA 2.A.1.1.5 Hexose transporter HXT10 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YHR092C r_4395 D-tagatose[e] <=> D-tagatose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM92401 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YHR094C r_4395 D-tagatose[e] <=> D-tagatose[c] Low-affinity glucose transporter. HXT1 is as well involved in the transport of mannose. MNXM92401 none "Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication" NA Low-affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT1 5 out of 5 NA "HXT1, HOR4; hexose transporter HXT1" NA HeXose Transporter NA 2.A.1.1.108 Low-affinity glucose transporter HXT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT1 PE=1 SV=1 FALSE -YHR096C r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication" NA Hexose transporter with moderate affinity for glucose NA Probable glucose transporter HXT5 4 out of 5 NA "HXT5; hexose transporter HXT5" NA HeXose Transporter NA NA NA FALSE -YJL214W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Protein of unknown function with similarity to hexose transporters NA Hexose transporter HXT8 4 out of 5 NA "HXT8; hexose transporter HXT8" NA HeXose Transporter NA NA NA FALSE -YJL219W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p" NA Putative hexose transporter that is nearly identical to Hxt11p NA Hexose transporter HXT9 4 out of 5 NA "HXT9; hexose transporter HXT9" NA HeXose Transporter NA NA NA FALSE -YJR158W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE -YMR011W r_4395 D-tagatose[e] <=> D-tagatose[c] High-affinity glucose transporter. Is only indispensable for growth on low glucose-containing media, because S.cerevisiae possesses other sugar transporters. MNXM92401 none "High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose" NA High-affinity glucose transporter of the major facilitator superfamily NA High-affinity glucose transporter HXT2 4 out of 5 NA "HXT2; hexose transporter HXT2" NA HeXose Transporter NA 2.A.1.1.111 High-affinity glucose transporter HXT2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT2 PE=1 SV=1 FALSE -YNR072W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE -YOL156W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance" NA Hexose transporter NA Hexose transporter HXT11 (Low-affinity glucose transporter LGT3) 4 out of 5 NA "HXT11, LGT3; hexose transporter HXT11" NA HeXose Transporter NA 2.A.1.1.105 Hexose transporter HXT11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT11 PE=1 SV=1 FALSE -YJR152W r_4398 H+[e] + Ala-Gln[e] <=> H+[c] + Ala-Gln[c] Component of the allantoate transport system. MNXM40495 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4398 H+[e] + Ala-Gln[e] <=> H+[c] + Ala-Gln[c] Uptake of small peptides. MNXM40495 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4402 H+[e] + Ala-Thr[e] <=> H+[c] + Ala-Thr[c] Component of the allantoate transport system. MNXM40497 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4402 H+[e] + Ala-Thr[e] <=> H+[c] + Ala-Thr[c] Uptake of small peptides. MNXM40497 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4404 H+[e] + Gly-Asn[e] <=> H+[c] + Gly-Asn[c] Component of the allantoate transport system. MNXM55268 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4404 H+[e] + Gly-Asn[e] <=> H+[c] + Gly-Asn[c] Uptake of small peptides. MNXM55268 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4408 H+[e] + Ala-Glu[e] <=> H+[c] + Ala-Glu[c] Component of the allantoate transport system. MNXM4026 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4408 H+[e] + Ala-Glu[e] <=> H+[c] + Ala-Glu[c] Uptake of small peptides. MNXM4026 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4424 H+[e] + Gly-Gln[e] <=> H+[c] + Gly-Gln[c] Component of the allantoate transport system. MNXM55276 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4424 H+[e] + Gly-Gln[e] <=> H+[c] + Gly-Gln[c] Uptake of small peptides. MNXM55276 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4429 H+[e] + Ala-His[e] <=> H+[c] + Ala-His[c] Component of the allantoate transport system. MNXM40496 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4429 H+[e] + Ala-His[e] <=> H+[c] + Ala-His[c] Uptake of small peptides. MNXM40496 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4437 H+[e] + Gly-Glu[e] <=> H+[c] + Gly-Glu[c] Component of the allantoate transport system. MNXM55454 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4437 H+[e] + Gly-Glu[e] <=> H+[c] + Gly-Glu[c] Uptake of small peptides. MNXM55454 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4448 H+[e] + Met-Ala[e] <=> H+[c] + Met-Ala[c] Component of the allantoate transport system. MNXM61647 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4448 H+[e] + Met-Ala[e] <=> H+[c] + Met-Ala[c] Uptake of small peptides. MNXM61647 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YDR093W r_4457 H+[e] + O-phosphoethanolamine[e] <=> H+[c] + O-phosphoethanolamine[c] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles. {ECO:0000269|PubMed:12221123}. MNXM187 h+ "Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication" 3.6.3.1 Aminophospholipid translocase (flippase) 3.6.3.1 Phospholipid-transporting ATPase DNF2 (EC 3.6.3.1) (Flippase DNF2) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF2; aminophospholipid-translocating P4-type ATPase DNF2" 3.6.3.1 Drs2 Neo1 Family "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.5 Probable phospholipid-transporting ATPase DNF2 (EC 3.6.3.1) - Saccharomyces cerevisiae (Baker's yeast) FALSE -YDR342C r_4468 2-deoxy-D-ribose[e] <=> 2-deoxy-D-ribose[c] High-affinity glucose transporter. MNXM2474 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE -YHR092C r_4468 2-deoxy-D-ribose[e] <=> 2-deoxy-D-ribose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM2474 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR039W r_4469 H+[e] + L-citrulline[e] <=> H+[c] + L-citrulline[c] General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449). {ECO:0000269|PubMed:10373490, ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10953083, ECO:0000269|PubMed:14968425, ECO:0000269|PubMed:15707981, ECO:0000269|PubMed:21471002, ECO:0000269|PubMed:22844449, ECO:0000269|PubMed:5474888}. MNXM211 h+ "General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth" NA General amino acid permease NA General amino-acid permease GAP1 5 out of 5 NA "GAP1; amino acid permease GAP1" NA General Amino acid Permease NA 2.A.3.10.2 General amino-acid permease GAP1 - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4471 H+[e] + Ala-Leu[e] <=> H+[c] + Ala-Leu[c] Component of the allantoate transport system. MNXM15786 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4471 H+[e] + Ala-Leu[e] <=> H+[c] + Ala-Leu[c] Uptake of small peptides. MNXM15786 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE -YJR152W r_4473 H+[e] + Ala-Gly[e] <=> H+[c] + Ala-Gly[c] Component of the allantoate transport system. MNXM15783 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE -YKR093W r_4473 H+[e] + Ala-Gly[e] <=> H+[c] + Ala-Gly[c] Uptake of small peptides. MNXM15783 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +gene rxnID formula annotation_uniprot main_met_mnx other_met annotation_SGD ec_SGD protein_name_SGD ec_uniprot protein_name_uniprot Annotation_score reaction_uniprot annotation_kegg ec_kegg annotation_biocyc annotation_reactome TC_number annotation_TCDB subunit +YGL077C r_1149 ethanolamine[e] <=> ethanolamine[c] Sole choline transporter in yeast. MNXM218 none "Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol" NA Plasma membrane transporter for choline, ethanolamine, and carnitine NA Choline transport protein 5 out of 5 NA "HNM1, CTR1; Hnm1p" NA Hyper-resistance to Nitrogen Mustard NA 2.A.3.4.1 Choline transport protein - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJL133W r_1179 iron(2+)[c] => iron(2+)[m] MRS3 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). MNXM111 none "Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication" NA Iron transporter, mediates Fe2+ transport across inner mito membrane NA Mitochondrial RNA-splicing protein MRS3 4 out of 5 NA "MRS3; Fe(2+) transporter" NA Mitochondrial RNA Splicing MRS3/4 Transports Iron Across the Mitochondrial Inner Membrane 2.A.29.5.1 Mitochondrial RNA-splicing protein MRS3 OS=Saccharomyces cerevisiae GN=MRS3 PE=1 SV=4 FALSE +YKR052C r_1179 iron(2+)[c] => iron(2+)[m] MRS4 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). Not essential. MNXM111 none "Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication" NA Iron transporter of the mitochondrial carrier family NA Mitochondrial RNA-splicing protein MRS4 4 out of 5 NA "MRS4; Fe(2+) transporter" NA Mitochondrial RNA Splicing MRS3/4 Transports Iron Across the Mitochondrial Inner Membrane 2.A.29.5.2 Mitochondrial RNA splicing protein MRS4 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKL188C r_1236 stearate[c] <=> stearate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM236 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE +YPL147W r_1236 stearate[c] <=> stearate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM236 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE +YKL120W r_1574 2-isopropylmalate[c] <=> 2-isopropylmalate[m] Transports oxaloacetate and sulfate. MNXM164143 none "Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family" NA Mitochondrial inner membrane transporter NA Mitochondrial oxaloacetate transport protein (Mitochondrial carrier protein PMT) 5 out of 5 NA "OAC1; Oac1p" NA OxaloAcetate Carrier NA 2.A.29.15.1 MITOCHONDRIAL CARRIER PROTEIN PMT - Saccharomyces cerevisiae (Baker's yeast). FALSE +YPR011C r_1642 adenosine 3',5'-bismonophosphate[c] <=> adenosine 3',5'-bismonophosphate[m] NA MNXM45 none "Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" NA Mitochondrial transporter NA Uncharacterized mitochondrial carrier YPR011C 3 out of 5 NA hypothetical protein NA YPR011C NA 2.A.29.23.9 Uncharacterized mitochondrial carrier YPR011C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPR011C PE=1 SV=1 FALSE +YBR147W r_1657 H+[c] + L-arginine[c] => H+[m] + L-arginine[m] May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. MNXM70 h+ "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" NA Putative vacuolar membrane transporter for cationic amino acids NA Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) 4 out of 5 NA "RTC2, RRT11, YPQ3; cationic amino acid transporter" NA Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 2.A.43.2.7 Protein RTC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTC2 PE=1 SV=1 FALSE +YDR508C r_1658 L-asparagine[c] => L-asparagine[m] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM147 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YGL077C r_1684 choline[ce] <=> choline[c] Sole choline transporter in yeast. MNXM90 none "Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol" NA Plasma membrane transporter for choline, ethanolamine, and carnitine NA Choline transport protein 5 out of 5 NA "HNM1, CTR1; Hnm1p" NA Hyper-resistance to Nitrogen Mustard NA 2.A.3.4.1 Choline transport protein - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR161C r_1684 choline[ce] <=> choline[c] Probably involved in transport through the plasma membrane. {ECO:0000250}. MNXM90 none "Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport" NA Protein of unknown function NA Protein PNS1 (pH nine-sensitive protein 1) 2 out of 5 NA "PNS1; Pns1p" NA pH Nine Sensitive "Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;SLC44A1 transports Cho from cytosol to mitochondrial matrix;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.92.1.8 Protein PNS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNS1 PE=1 SV=1 FALSE +YDR342C r_1707 D-arabinose[e] <=> D-arabinose[c] High-affinity glucose transporter. MNXM48397 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YHR092C r_1707 D-arabinose[e] <=> D-arabinose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM48397 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDL245C r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE +YEL069C r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE +YJR158W r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE +YNR072W r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE +YHR092C r_1719 D-xylose[e] <=> D-xylose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM90941 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YBL042C r_1735 2'-deoxyuridine[e] => 2'-deoxyuridine[c] High-affinity transport of uridine. MNXM492 none "High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress" NA High affinity uridine permease, localizes to the plasma membrane NA Uridine permease 4 out of 5 NA "FUI1; uridine permease" NA 5-FlUorourIdine resistance NA 2.A.39.3.3 URIDINE PERMEASE - Saccharomyces cerevisiae (Baker's yeast). FALSE +YIL013C r_1760 ergosterol[c] <=> ergosterol[ce] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM922 none "ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication" NA ATP-binding cassette (ABC) transporter NA ATP-dependent permease PDR11 4 out of 5 NA "PDR11; ATP-binding cassette multidrug transporter PDR11" NA Pleiotropic Drug Resistance NA 3.A.1.205.8 ATP-dependent permease PDR11 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR011W r_1760 ergosterol[c] <=> ergosterol[ce] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM922 none "Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication" NA Plasma membrane sterol transporter of the ATP-binding cassette family NA ATP-dependent permease AUS1 3 out of 5 NA "AUS1; ATP-binding cassette sterol transporter AUS1" NA ABC protein involved in Uptake of Sterols NA 3.A.1.205.15 ATP-dependent permease AUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AUS1 PE=1 SV=1 FALSE +YKL188C r_1771 laurate[c] <=> laurate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM402 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE +YPL147W r_1771 laurate[c] <=> laurate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM402 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE +YKL188C r_1772 myristate[c] <=> myristate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM314 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE +YPL147W r_1772 myristate[c] <=> myristate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM314 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE +YKL188C r_1774 palmitate[c] <=> palmitate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM108 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE +YPL147W r_1774 palmitate[c] <=> palmitate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM108 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE +YNL065W r_1795 formate[e] <=> formate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM39 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YGL225W r_1803 GDP-alpha-D-mannose[c] <=> GDP-alpha-D-mannose[g] Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity. {ECO:0000269|PubMed:10570930, ECO:0000269|PubMed:11067855, ECO:0000269|PubMed:12478588, ECO:0000269|PubMed:15494368, ECO:0000269|PubMed:2014241, ECO:0000269|PubMed:2137555, ECO:0000269|PubMed:7672592, ECO:0000269|PubMed:7877969, ECO:0000269|PubMed:8632002, ECO:0000269|PubMed:9184829, ECO:0000269|PubMed:9335583, ECO:0000269|PubMed:9395539}. MNXM82 none "Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication" NA Golgi GDP-mannose transporter NA GDP-mannose transporter 1 (GMT 1) (Low dye-binding protein 3) (Morphogenesis checkpoint-dependent protein 3) (Vanadate resistance glycosylation protein 4) 5 out of 5 NA "VRG4, GOG5, LDB3, VAN2, VIG4; GDP-mannose transporter" NA Vandate Resistance Glycosylation NA 2.A.7.13.1 Vanadate resistance protein GOG5/VRG4/VAN2 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YPR058W r_1811 L-glycine[c] <=> L-glycine[m] NA MNXM29 none "Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication" NA Secondary mitochondrial inner membrane glycine transporter NA Carrier protein YMC1, mitochondrial 3 out of 5 NA "YMC1; organic acid transporter" NA Yeast Mitochondrial Carrier NA 2.A.29.8.12 Carrier protein YMC1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YMC1 PE=1 SV=2 FALSE +YNL065W r_1816 glyoxylate[c] <=> glyoxylate[e] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM69 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YBR147W r_1837 L-histidine[c] => L-histidine[m] May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. MNXM134 none "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" NA Putative vacuolar membrane transporter for cationic amino acids NA Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) 4 out of 5 NA "RTC2, RRT11, YPQ3; cationic amino acid transporter" NA Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 2.A.43.2.7 Protein RTC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTC2 PE=1 SV=1 FALSE +YDR342C r_1877 L-arabinose[e] <=> L-arabinose[c] High-affinity glucose transporter. MNXM461 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YHR092C r_1877 L-arabinose[e] <=> L-arabinose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM461 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR100C r_1882 (R)-carnitine[m] => (R)-carnitine[c] Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines. {ECO:0000269|PubMed:10545096, ECO:0000269|PubMed:10622748}. MNXM173 none "Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant" NA Mitochondrial inner membrane carnitine transporter NA Mitochondrial carnitine carrier 3 out of 5 NA "CRC1; carnitine:acyl carnitine antiporter" NA CaRnitine Carrier "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane;SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix" 2.A.29.8.4 Mitochondrial carnitine carrier - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR039W r_1907 L-serine[c] <=> L-serine[er] General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449). {ECO:0000269|PubMed:10373490, ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10953083, ECO:0000269|PubMed:14968425, ECO:0000269|PubMed:15707981, ECO:0000269|PubMed:21471002, ECO:0000269|PubMed:22844449, ECO:0000269|PubMed:5474888}. MNXM53 none "General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth" NA General amino acid permease NA General amino-acid permease GAP1 5 out of 5 NA "GAP1; amino acid permease GAP1" NA General Amino acid Permease NA 2.A.3.10.2 General amino-acid permease GAP1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDL245C r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE +YEL069C r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE +YJR158W r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE +YNR072W r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE +YDL245C r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE +YDR342C r_1910 L-sorbose[e] <=> L-sorbose[c] High-affinity glucose transporter. MNXM588 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YDR343C r_1910 L-sorbose[e] <=> L-sorbose[c] High-affinity glucose transporter. MNXM588 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT6 4 out of 5 NA "HXT6; hexose transporter HXT6" NA HeXose Transporter NA NA NA FALSE +YDR345C r_1910 L-sorbose[e] <=> L-sorbose[c] Low-affinity glucose transporter. MNXM588 none "Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication" NA Low affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT3 5 out of 5 NA "HXT3; hexose transporter HXT3" NA HeXose Transporter NA NA NA FALSE +YEL069C r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE +YFL011W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative hexose transporter; expressed at low levels and expression is repressed by glucose" NA Putative hexose transporter NA Hexose transporter HXT10 4 out of 5 NA "HXT10; hexose transporter HXT10" NA HeXose Transporter NA 2.A.1.1.5 Hexose transporter HXT10 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YHR092C r_1910 L-sorbose[e] <=> L-sorbose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM588 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YHR094C r_1910 L-sorbose[e] <=> L-sorbose[c] Low-affinity glucose transporter. HXT1 is as well involved in the transport of mannose. MNXM588 none "Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication" NA Low-affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT1 5 out of 5 NA "HXT1, HOR4; hexose transporter HXT1" NA HeXose Transporter NA 2.A.1.1.108 Low-affinity glucose transporter HXT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT1 PE=1 SV=1 FALSE +YHR096C r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication" NA Hexose transporter with moderate affinity for glucose NA Probable glucose transporter HXT5 4 out of 5 NA "HXT5; hexose transporter HXT5" NA HeXose Transporter NA NA NA FALSE +YJL214W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Protein of unknown function with similarity to hexose transporters NA Hexose transporter HXT8 4 out of 5 NA "HXT8; hexose transporter HXT8" NA HeXose Transporter NA NA NA FALSE +YJL219W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p" NA Putative hexose transporter that is nearly identical to Hxt11p NA Hexose transporter HXT9 4 out of 5 NA "HXT9; hexose transporter HXT9" NA HeXose Transporter NA NA NA FALSE +YJR158W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE +YMR011W r_1910 L-sorbose[e] <=> L-sorbose[c] High-affinity glucose transporter. Is only indispensable for growth on low glucose-containing media, because S.cerevisiae possesses other sugar transporters. MNXM588 none "High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose" NA High-affinity glucose transporter of the major facilitator superfamily NA High-affinity glucose transporter HXT2 4 out of 5 NA "HXT2; hexose transporter HXT2" NA HeXose Transporter NA 2.A.1.1.111 High-affinity glucose transporter HXT2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT2 PE=1 SV=1 FALSE +YNR072W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE +YOL156W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance" NA Hexose transporter NA Hexose transporter HXT11 (Low-affinity glucose transporter LGT3) 4 out of 5 NA "HXT11, LGT3; hexose transporter HXT11" NA HeXose Transporter NA 2.A.1.1.105 Hexose transporter HXT11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT11 PE=1 SV=1 FALSE +YBR147W r_1919 L-lysine[c] => L-lysine[m] May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. MNXM78 none "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" NA Putative vacuolar membrane transporter for cationic amino acids NA Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) 4 out of 5 NA "RTC2, RRT11, YPQ3; cationic amino acid transporter" NA Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 2.A.43.2.7 Protein RTC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTC2 PE=1 SV=1 FALSE +YDR508C r_1935 L-methionine[m] => L-methionine[c] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM61 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR100C r_1976 O-acetylcarnitine[c] => O-acetylcarnitine[m] Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines. {ECO:0000269|PubMed:10545096, ECO:0000269|PubMed:10622748}. MNXM1028 none "Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant" NA Mitochondrial inner membrane carnitine transporter NA Mitochondrial carnitine carrier 3 out of 5 NA "CRC1; carnitine:acyl carnitine antiporter" NA CaRnitine Carrier "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane;SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix" 2.A.29.8.4 Mitochondrial carnitine carrier - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJL212C r_1990 glutathione disulfide[e] => glutathione disulfide[c] High affinity transporter for glutathione. Also transports tetra- and pentapeptides like the opioids leucine enkephalin (Tyr-Gly-Gly-Phe-Leu) and methionine enkephalin (Tyr-Gly-Gly_Phe-Met) across the cell membrane. {ECO:0000269|PubMed:10652283, ECO:0000269|PubMed:10788431}. MNXM151 none "Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family" NA Proton-coupled oligopeptide transporter of the plasma membrane NA Oligopeptide transporter 1 (High affinity glutathione transporter 1) 4 out of 5 NA "OPT1, GSH11, HGT1; oligopeptide transporter OPT1" NA OligoPeptide Transporter NA 2.A.67.1.3 HYPOTHETICAL 91.6 KDA PROTEIN IN HXT8-CRT1 INTERGENIC REGION - Saccharomyces cerevisiae (Baker's yeast). FALSE +YNR013C r_2008 phosphate[c] <=> phosphate[v] Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol. {ECO:0000269|PubMed:11779791, ECO:0000269|PubMed:17804816, ECO:0000269|PubMed:20133652}. MNXM9 none "Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth" NA Low-affinity vacuolar phosphate transporter NA Low-affinity phosphate transporter PHO91 5 out of 5 NA "PHO91; Pho91p" NA PHOsphate metabolism NA 2.A.47.2.2 Uncharacterized transporter YNR013C - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR306C r_2040 riboflavin[e] => riboflavin[c] Riboflavin transporter involved in riboflavin (vitamin B2) uptake. Does not act in the transport of monocarboxylic acids across the plasma membrane. {ECO:0000269|PubMed:16204239}. MNXM270 none "Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport" NA Plasma membrane riboflavin transporter NA Riboflavin transporter MCH5 3 out of 5 NA "MCH5; Mch5p" NA MonoCarboxylate transporter Homologue NA 2.A.1.13.4 S.cerevisiae chromosome XV reading frame ORF YOR306c - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDR342C r_2041 D-ribose[e] => D-ribose[c] High-affinity glucose transporter. MNXM242 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YHR092C r_2041 D-ribose[e] => D-ribose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM242 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDR508C r_2045 L-serine[c] <=> L-serine[m] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM53 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDR508C r_2072 L-threonine[c] => L-threonine[m] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM142 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YLL052C r_2094 H2O[c] <=> H2O[er] Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains. {ECO:0000250}. MNXM2 none "Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" NA Water channel that mediates water transport across cell membranes NA Aquaporin-like protein 2 (Truncated aquaporin-2) 4 out of 5 NA "AQY2; Aqy2p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YPR192W r_2094 H2O[c] <=> H2O[er] Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains. {ECO:0000250, ECO:0000269|PubMed:10092523, ECO:0000269|PubMed:10870101, ECO:0000269|PubMed:9765289}. MNXM2 none "Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" NA Spore-specific water channel NA Aquaporin-1 5 out of 5 NA "AQY1; Aqy1p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YDL245C r_2105 xylitol[e] <=> xylitol[c] Probable glucose transporter. MNXM510 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE +YLL043W r_2105 xylitol[e] <=> xylitol[c] Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation: under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions. MNXM510 none "Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state" NA Aquaglyceroporin, plasma membrane channel NA Glycerol uptake/efflux facilitator protein 5 out of 5 NA "FPS1; Fps1p" NA fdp1 Suppressor NA 1.A.8.5.1 GLYCEROL UPTAKE/EFFLUX FACILITATOR PROTEIN - Saccharomyces cerevisiae (Baker's yeast). FALSE +YIL013C r_2107 zymosterol[ce] <=> zymosterol[c] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM574 none "ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication" NA ATP-binding cassette (ABC) transporter NA ATP-dependent permease PDR11 4 out of 5 NA "PDR11; ATP-binding cassette multidrug transporter PDR11" NA Pleiotropic Drug Resistance NA 3.A.1.205.8 ATP-dependent permease PDR11 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR011W r_2107 zymosterol[ce] <=> zymosterol[c] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM574 none "Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication" NA Plasma membrane sterol transporter of the ATP-binding cassette family NA ATP-dependent permease AUS1 3 out of 5 NA "AUS1; ATP-binding cassette sterol transporter AUS1" NA ABC protein involved in Uptake of Sterols NA 3.A.1.205.15 ATP-dependent permease AUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AUS1 PE=1 SV=1 FALSE +YNL065W r_2190 butyrate[e] <=> butyrate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM458 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YNL065W r_2191 hexanoate[e] <=> hexanoate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM1653 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKL188C r_2231 oleate[c] <=> oleate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM306 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE +YPL147W r_2231 oleate[c] <=> oleate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM306 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE +YLL052C r_3526 H2O[c] <=> H2O[erm] Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains. {ECO:0000250}. MNXM2 none "Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" NA Water channel that mediates water transport across cell membranes NA Aquaporin-like protein 2 (Truncated aquaporin-2) 4 out of 5 NA "AQY2; Aqy2p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YPR192W r_3526 H2O[c] <=> H2O[erm] Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains. {ECO:0000250, ECO:0000269|PubMed:10092523, ECO:0000269|PubMed:10870101, ECO:0000269|PubMed:9765289}. MNXM2 none "Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" NA Spore-specific water channel NA Aquaporin-1 5 out of 5 NA "AQY1; Aqy1p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YKR039W r_3545 L-serine[c] <=> L-serine[erm] General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449). {ECO:0000269|PubMed:10373490, ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10953083, ECO:0000269|PubMed:14968425, ECO:0000269|PubMed:15707981, ECO:0000269|PubMed:21471002, ECO:0000269|PubMed:22844449, ECO:0000269|PubMed:5474888}. MNXM53 none "General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth" NA General amino acid permease NA General amino-acid permease GAP1 5 out of 5 NA "GAP1; amino acid permease GAP1" NA General Amino acid Permease NA 2.A.3.10.2 General amino-acid permease GAP1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YLL052C r_3604 H2O[c] <=> H2O[ce] Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains. {ECO:0000250}. MNXM2 none "Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" NA Water channel that mediates water transport across cell membranes NA Aquaporin-like protein 2 (Truncated aquaporin-2) 4 out of 5 NA "AQY2; Aqy2p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YLL053C r_3604 H2O[c] <=> H2O[ce] NA MNXM2 none "Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin" NA Putative protein NA Putative uncharacterized protein YLL053C 2 out of 5 NA hypothetical protein NA YLL053C "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YPR192W r_3604 H2O[c] <=> H2O[ce] Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains. {ECO:0000250, ECO:0000269|PubMed:10092523, ECO:0000269|PubMed:10870101, ECO:0000269|PubMed:9765289}. MNXM2 none "Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" NA Spore-specific water channel NA Aquaporin-1 5 out of 5 NA "AQY1; Aqy1p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YCR037C r_3605 phosphate[c] <=> phosphate[ce] Involved in the uptake of inorganic phosphate. MNXM9 none "Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of the PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication" NA Low-affinity inorganic phosphate (Pi) transporter NA Inorganic phosphate transporter PHO87 4 out of 5 NA "PHO87; SPX domain-containing inorganic phosphate transporter" NA PHOsphate metabolism NA 2.A.47.2.1 INORGANIC PHOSPHATE TRANSPORTER PHO87 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJL198W r_3605 phosphate[c] <=> phosphate[ce] Low-affinity phosphate transporter involved in the control of cellular phosphate levels. {ECO:0000269|PubMed:11779791, ECO:0000269|PubMed:20133652}. MNXM9 none "Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication" NA Low-affinity phosphate transporter NA Low-affinity phosphate transporter PHO90 4 out of 5 NA "PHO90; SPX domain-containing inorganic phosphate transporter" NA PHOsphate metabolism NA 2.A.47.2.3 Low-affinity phosphate transporter PHO90 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHO90 PE=1 SV=1 FALSE +YML123C r_3605 phosphate[c] <=> phosphate[ce] High-affinity transporter for external inorganic phosphate. Is not an essential protein, since a constitutive, low affinity pI transporter exists in yeast. MNXM9 none "High-affinity inorganic phosphate (Pi) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity" NA High-affinity inorganic phosphate (Pi) transporter NA Inorganic phosphate transporter PHO84 5 out of 5 NA "PHO84; phosphate transporter PHO84" NA PHOsphate metabolism NA 2.A.1.9.1 Inorganic phosphate transporter PHO84 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YCR098C r_3606 sn-glycero-3-phosphocholine[ce] <=> sn-glycero-3-phosphocholine[c] Glycerophosphodiester transporter that mediates uptake of both glycerophosphoinositol (GroPIns) and glycerophosphocholine (GroPCho) as sources of the nutrients inositol and phosphate (PubMed:9691030, PubMed:12912892, PubMed:16141200). {ECO:0000269|PubMed:12912892, ECO:0000269|PubMed:16141200, ECO:0000269|PubMed:9691030}. MNXM367 none "Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability" NA Plasma membrane permease NA Glycerophosphoinositol transporter 1 4 out of 5 NA "GIT1; Git1p" NA GlycerophosphoInosiTol NA 2.A.1.9.7 Probable metabolite transport protein GIT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GIT1 PE=1 SV=1 FALSE +YCR098C r_3607 1-(sn-glycero-3-phospho)-1D-myo-inositol[ce] <=> 1-(sn-glycero-3-phospho)-1D-myo-inositol[c] Glycerophosphodiester transporter that mediates uptake of both glycerophosphoinositol (GroPIns) and glycerophosphocholine (GroPCho) as sources of the nutrients inositol and phosphate (PubMed:9691030, PubMed:12912892, PubMed:16141200). {ECO:0000269|PubMed:12912892, ECO:0000269|PubMed:16141200, ECO:0000269|PubMed:9691030}. MNXM1517 none "Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability" NA Plasma membrane permease NA Glycerophosphoinositol transporter 1 4 out of 5 NA "GIT1; Git1p" NA GlycerophosphoInosiTol NA 2.A.1.9.7 Probable metabolite transport protein GIT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GIT1 PE=1 SV=1 FALSE +YNR013C r_3649 phosphate[c] <=> phosphate[vm] Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol. {ECO:0000269|PubMed:11779791, ECO:0000269|PubMed:17804816, ECO:0000269|PubMed:20133652}. MNXM9 none "Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth" NA Low-affinity vacuolar phosphate transporter NA Low-affinity phosphate transporter PHO91 5 out of 5 NA "PHO91; Pho91p" NA PHOsphate metabolism NA 2.A.47.2.2 Uncharacterized transporter YNR013C - Saccharomyces cerevisiae (Baker's yeast). FALSE +YHR002W r_3680 coenzyme A[mm] <=> coenzyme A[c] Required for the accumulation of coenzyme A in the mitochondrial matrix. {ECO:0000269|PubMed:11158296}. MNXM12 none "Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized" NA Mitochondrial carrier protein NA Mitochondrial carrier protein LEU5 3 out of 5 NA "LEU5; coenzyme A transporter" NA LEUcine biosynthesis SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix 2.A.29.12.4 Mitochondrial carrier protein LEU5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LEU5 PE=2 SV=1 FALSE +YIL048W r_3813 phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78605 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3813 phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78605 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3814 phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. NA none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3814 phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. NA none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3815 phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78765 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3815 phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78765 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3816 phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78797 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3816 phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78797 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3817 phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680894 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3817 phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM680894 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3818 phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78642 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3818 phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78642 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3819 phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680500 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3819 phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM680500 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3820 phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM32173 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3820 phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM32173 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YAL026C r_3821 phosphatidylethanolamine (1-16:0, 2-16:1)[gm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588855 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3822 phosphatidylethanolamine (1-16:1, 2-16:1)[gm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. NA none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3823 phosphatidylethanolamine (1-18:0, 2-16:1)[gm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588866 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3824 phosphatidylethanolamine (1-18:1, 2-16:1)[gm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM71684 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3825 phosphatidylethanolamine (1-16:0, 2-18:1)[gm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588857 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3826 phosphatidylethanolamine (1-16:1, 2-18:1)[gm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM611809 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3827 phosphatidylethanolamine (1-18:0, 2-18:1)[gm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588872 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3828 phosphatidylethanolamine (1-18:1, 2-18:1)[gm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588883 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3885 phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588855 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3886 phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. NA none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3887 phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588866 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3888 phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM71684 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3889 phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588857 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3890 phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM611809 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3891 phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588872 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3892 phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588883 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YIL048W r_3893 phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78605 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3894 phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. NA none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3895 phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78765 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3896 phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78797 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3897 phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680894 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3898 phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78642 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3899 phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680500 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3900 phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM32173 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YBR192W r_3959 CMP[m] <=> CMP[mm] NA MNXM31 none "Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family" NA Mitochondrial pyrimidine nucleotide transporter NA Mitochondrial carrier protein RIM2 4 out of 5 NA "RIM2, PYT1; Rim2p" NA Replication In Mitochondria NA 2.A.29.10.4 2.A.29.10.4 Mitochondrial carrier protein RIM2 FALSE +YBR192W r_3960 CTP[m] <=> CTP[mm] NA MNXM63 none "Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family" NA Mitochondrial pyrimidine nucleotide transporter NA Mitochondrial carrier protein RIM2 4 out of 5 NA "RIM2, PYT1; Rim2p" NA Replication In Mitochondria NA 2.A.29.10.4 2.A.29.10.4 Mitochondrial carrier protein RIM2 FALSE +YER053C r_3961 phosphate[m] <=> phosphate[mm] Transport of phosphate groups from the cytosol to the mitochondrial matrix. {ECO:0000269|PubMed:11328608, ECO:0000269|PubMed:14756774}. MNXM9 none "Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature" NA Mitochondrial copper and phosphate carrier NA Mitochondrial phosphate carrier protein 2 (Phosphate transport protein 2) (PTP 2) (Pi carrier isoform 2) (mPic 2) 5 out of 5 NA "PIC2; Cu/Pi carrier" NA PI Carrier NA 2.A.29.4.4 Mitochondrial phosphate carrier protein 2 OS=Saccharomyces cerevisiae GN=PIC2 PE=1 SV=1 FALSE +YJR077C r_3961 phosphate[m] <=> phosphate[mm] Transport of phosphate groups from the cytosol to the mitochondrial matrix. MNXM9 none "Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated" NA Mitochondrial phosphate carrier NA Mitochondrial phosphate carrier protein (Mitochondrial import receptor) (Phosphate transport protein) (PTP) (mPic 1) (p32) [Cleaved into: Mitochondrial phosphate carrier protein, N-terminally processed] 5 out of 5 NA "MIR1; Mir1p" NA MIR1 "TIM22 complex inserts proteins into inner membrane;TIM22 complex inserts proteins into inner membrane" 2.A.29.4.3 Mitochondrial phosphate carrier protein OS=Saccharomyces cerevisiae GN=MIR1 PE=1 SV=1 FALSE +YLR348C r_3961 phosphate[m] <=> phosphate[mm] Mitochondrial dicarboxylic transporter catalyzing the exchange of dicarboxylic acids like malate and succinate for inorganic phosphate. Required for growth on ethanol and acetate. {ECO:0000269|PubMed:10027973, ECO:0000269|PubMed:8831951, ECO:0000269|PubMed:9020177, ECO:0000269|PubMed:9559855}. MNXM9 none "Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix" NA Mitochondrial dicarboxylate carrier NA Mitochondrial dicarboxylate transporter (DTP) (Dicarboxylate carrier 1) 5 out of 5 NA "DIC1; Dic1p" NA DIcarboxylate Carrier "Sulfate is exported to the cytosol in exchange for dicarboxylate;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix];malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix];Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane" 2.A.29.2.3 BELONGS TO THE MITOCHONDRIAL CARRIER FAMILY - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4361 H+[e] + Gly-Met[e] <=> H+[c] + Gly-Met[c] Component of the allantoate transport system. MNXM55287 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4361 H+[e] + Gly-Met[e] <=> H+[c] + Gly-Met[c] Uptake of small peptides. MNXM55287 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4387 H+[e] + Ala-Asp[e] <=> H+[c] + Ala-Asp[c] Component of the allantoate transport system. MNXM40494 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4387 H+[e] + Ala-Asp[e] <=> H+[c] + Ala-Asp[c] Uptake of small peptides. MNXM40494 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDL245C r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE +YDR342C r_4395 D-tagatose[e] <=> D-tagatose[c] High-affinity glucose transporter. MNXM92401 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YDR343C r_4395 D-tagatose[e] <=> D-tagatose[c] High-affinity glucose transporter. MNXM92401 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT6 4 out of 5 NA "HXT6; hexose transporter HXT6" NA HeXose Transporter NA NA NA FALSE +YDR345C r_4395 D-tagatose[e] <=> D-tagatose[c] Low-affinity glucose transporter. MNXM92401 none "Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication" NA Low affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT3 5 out of 5 NA "HXT3; hexose transporter HXT3" NA HeXose Transporter NA NA NA FALSE +YEL069C r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE +YFL011W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative hexose transporter; expressed at low levels and expression is repressed by glucose" NA Putative hexose transporter NA Hexose transporter HXT10 4 out of 5 NA "HXT10; hexose transporter HXT10" NA HeXose Transporter NA 2.A.1.1.5 Hexose transporter HXT10 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YHR092C r_4395 D-tagatose[e] <=> D-tagatose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM92401 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YHR094C r_4395 D-tagatose[e] <=> D-tagatose[c] Low-affinity glucose transporter. HXT1 is as well involved in the transport of mannose. MNXM92401 none "Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication" NA Low-affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT1 5 out of 5 NA "HXT1, HOR4; hexose transporter HXT1" NA HeXose Transporter NA 2.A.1.1.108 Low-affinity glucose transporter HXT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT1 PE=1 SV=1 FALSE +YHR096C r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication" NA Hexose transporter with moderate affinity for glucose NA Probable glucose transporter HXT5 4 out of 5 NA "HXT5; hexose transporter HXT5" NA HeXose Transporter NA NA NA FALSE +YJL214W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Protein of unknown function with similarity to hexose transporters NA Hexose transporter HXT8 4 out of 5 NA "HXT8; hexose transporter HXT8" NA HeXose Transporter NA NA NA FALSE +YJL219W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p" NA Putative hexose transporter that is nearly identical to Hxt11p NA Hexose transporter HXT9 4 out of 5 NA "HXT9; hexose transporter HXT9" NA HeXose Transporter NA NA NA FALSE +YJR158W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE +YMR011W r_4395 D-tagatose[e] <=> D-tagatose[c] High-affinity glucose transporter. Is only indispensable for growth on low glucose-containing media, because S.cerevisiae possesses other sugar transporters. MNXM92401 none "High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose" NA High-affinity glucose transporter of the major facilitator superfamily NA High-affinity glucose transporter HXT2 4 out of 5 NA "HXT2; hexose transporter HXT2" NA HeXose Transporter NA 2.A.1.1.111 High-affinity glucose transporter HXT2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT2 PE=1 SV=1 FALSE +YNR072W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE +YOL156W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance" NA Hexose transporter NA Hexose transporter HXT11 (Low-affinity glucose transporter LGT3) 4 out of 5 NA "HXT11, LGT3; hexose transporter HXT11" NA HeXose Transporter NA 2.A.1.1.105 Hexose transporter HXT11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT11 PE=1 SV=1 FALSE +YJR152W r_4398 H+[e] + Ala-Gln[e] <=> H+[c] + Ala-Gln[c] Component of the allantoate transport system. MNXM40495 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4398 H+[e] + Ala-Gln[e] <=> H+[c] + Ala-Gln[c] Uptake of small peptides. MNXM40495 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4402 H+[e] + Ala-Thr[e] <=> H+[c] + Ala-Thr[c] Component of the allantoate transport system. MNXM40497 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4402 H+[e] + Ala-Thr[e] <=> H+[c] + Ala-Thr[c] Uptake of small peptides. MNXM40497 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4404 H+[e] + Gly-Asn[e] <=> H+[c] + Gly-Asn[c] Component of the allantoate transport system. MNXM55268 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4404 H+[e] + Gly-Asn[e] <=> H+[c] + Gly-Asn[c] Uptake of small peptides. MNXM55268 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4408 H+[e] + Ala-Glu[e] <=> H+[c] + Ala-Glu[c] Component of the allantoate transport system. MNXM4026 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4408 H+[e] + Ala-Glu[e] <=> H+[c] + Ala-Glu[c] Uptake of small peptides. MNXM4026 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4424 H+[e] + Gly-Gln[e] <=> H+[c] + Gly-Gln[c] Component of the allantoate transport system. MNXM55276 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4424 H+[e] + Gly-Gln[e] <=> H+[c] + Gly-Gln[c] Uptake of small peptides. MNXM55276 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4429 H+[e] + Ala-His[e] <=> H+[c] + Ala-His[c] Component of the allantoate transport system. MNXM40496 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4429 H+[e] + Ala-His[e] <=> H+[c] + Ala-His[c] Uptake of small peptides. MNXM40496 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4437 H+[e] + Gly-Glu[e] <=> H+[c] + Gly-Glu[c] Component of the allantoate transport system. MNXM55454 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4437 H+[e] + Gly-Glu[e] <=> H+[c] + Gly-Glu[c] Uptake of small peptides. MNXM55454 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4448 H+[e] + Met-Ala[e] <=> H+[c] + Met-Ala[c] Component of the allantoate transport system. MNXM61647 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4448 H+[e] + Met-Ala[e] <=> H+[c] + Met-Ala[c] Uptake of small peptides. MNXM61647 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDR093W r_4457 H+[e] + O-phosphoethanolamine[e] <=> H+[c] + O-phosphoethanolamine[c] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles. {ECO:0000269|PubMed:12221123}. MNXM187 h+ "Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication" 3.6.3.1 Aminophospholipid translocase (flippase) 3.6.3.1 Phospholipid-transporting ATPase DNF2 (EC 3.6.3.1) (Flippase DNF2) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF2; aminophospholipid-translocating P4-type ATPase DNF2" 3.6.3.1 Drs2 Neo1 Family "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.5 Probable phospholipid-transporting ATPase DNF2 (EC 3.6.3.1) - Saccharomyces cerevisiae (Baker's yeast) FALSE +YDR342C r_4468 2-deoxy-D-ribose[e] <=> 2-deoxy-D-ribose[c] High-affinity glucose transporter. MNXM2474 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YHR092C r_4468 2-deoxy-D-ribose[e] <=> 2-deoxy-D-ribose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM2474 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR039W r_4469 H+[e] + L-citrulline[e] <=> H+[c] + L-citrulline[c] General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449). {ECO:0000269|PubMed:10373490, ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10953083, ECO:0000269|PubMed:14968425, ECO:0000269|PubMed:15707981, ECO:0000269|PubMed:21471002, ECO:0000269|PubMed:22844449, ECO:0000269|PubMed:5474888}. MNXM211 h+ "General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth" NA General amino acid permease NA General amino-acid permease GAP1 5 out of 5 NA "GAP1; amino acid permease GAP1" NA General Amino acid Permease NA 2.A.3.10.2 General amino-acid permease GAP1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4471 H+[e] + Ala-Leu[e] <=> H+[c] + Ala-Leu[c] Component of the allantoate transport system. MNXM15786 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4471 H+[e] + Ala-Leu[e] <=> H+[c] + Ala-Leu[c] Uptake of small peptides. MNXM15786 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4473 H+[e] + Ala-Gly[e] <=> H+[c] + Ala-Gly[c] Component of the allantoate transport system. MNXM15783 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4473 H+[e] + Ala-Gly[e] <=> H+[c] + Ala-Gly[c] Uptake of small peptides. MNXM15783 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE YNL065W r_4493 acetoacetate[e] <=> acetoacetate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM154 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE \ No newline at end of file diff --git a/ComplementaryData/databases/lipidAbbreviations.csv b/ComplementaryData/databases/lipidAbbreviations.csv new file mode 100644 index 00000000..149d9364 --- /dev/null +++ b/ComplementaryData/databases/lipidAbbreviations.csv @@ -0,0 +1,26 @@ +mag;1-monoglyceride +dag;diglyceride +dag2p;1,2-diacylglycerol 3-diphosphate +cdpdag;CDP-diacylglycerol +tag;triglyceride +pa;phosphatidate +ps;phosphatidyl-L-serine +agps;1-acylglycerophosphoserine +pe;phosphatidylethanolamine +mmpe;phosphatidyl-N-methylethanolamine +dmpe;phosphatidyl-N,N-dimethylethanolamine +agpe;1-acylglycerophosphoethanolamine +pc;phosphatidylcholine +agpc;1-acylglycerophosphocholine +lcb;long-chain base +pail;1-phosphatidyl-1D-myo-inositol +lpi;sn-2-acyl-1-lysophosphatidylinositol +cer;ceramide +ipc;inositol-P-ceramide +mipc;mannosylinositol phosphorylceramide +mip2c;inositol phosphomannosylinositol phosphoceramide +pg1p;3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate +agp;acylglycerone phosphate +pg;phosphatidylglycerol +cl;cardiolipin +mlcl;monolysocardiolipin diff --git a/ComplementaryData/modelCuration/Biolog_newRxnMatrix.tsv b/ComplementaryData/modelCuration/Biolog_newRxnMatrix.tsv index f70f9f09..3023dda0 100644 --- a/ComplementaryData/modelCuration/Biolog_newRxnMatrix.tsv +++ b/ComplementaryData/modelCuration/Biolog_newRxnMatrix.tsv @@ -1,571 +1,571 @@ -rxnID coefficient Metabolite standard name Metabolite_type compartment -MNXR137087 1 Ala-Gln reactant extracellular -MNXR137087 1 H+ reactant extracellular -MNXR137087 1 H+ product cytoplasm -MNXR137087 1 Ala-Gln product cytoplasm -MNXR137087_cv 1 H+ reactant cytoplasm -MNXR137087_cv 1 Ala-Gln reactant cytoplasm -MNXR137087_cv 1 H+ product vacuole -MNXR137087_cv 1 Ala-Gln product vacuole -MNXR123345 1 Ala-Gln reactant vacuole -MNXR123345 1 H2O reactant vacuole -MNXR123345 1 L-glutamine product vacuole -MNXR123345 1 L-alanine product vacuole -MNXR101006 1 Ala-Glu reactant extracellular -MNXR101006 1 H+ reactant extracellular -MNXR101006 1 H+ product cytoplasm -MNXR101006 1 Ala-Glu product cytoplasm -MNXR101006_cv 1 H+ reactant cytoplasm -MNXR101006_cv 1 Ala-Glu reactant cytoplasm -MNXR101006_cv 1 H+ product vacuole -MNXR101006_cv 1 Ala-Glu product vacuole -MNXR101011 1 Ala-Glu reactant vacuole -MNXR101011 1 H2O reactant vacuole -MNXR101011 1 L-glutamate product vacuole -MNXR101011 1 L-alanine product vacuole -Ala-Thr transport via proton symport (extracellular to cytosol) 1 Ala-Thr reactant extracellular -Ala-Thr transport via proton symport (extracellular to cytosol) 1 H+ reactant extracellular -Ala-Thr transport via proton symport (extracellular to cytosol) 1 H+ product cytoplasm -Ala-Thr transport via proton symport (extracellular to cytosol) 1 Ala-Thr product cytoplasm -Ala-Thr transport via proton symport (cytosol to vacuole) 1 H+ reactant cytoplasm -Ala-Thr transport via proton symport (cytosol to vacuole) 1 Ala-Thr reactant cytoplasm -Ala-Thr transport via proton symport (cytosol to vacuole) 1 H+ product vacuole -Ala-Thr transport via proton symport (cytosol to vacuole) 1 Ala-Thr product vacuole -MNXR123349 1 Ala-Thr reactant vacuole -MNXR123349 1 H2O reactant vacuole -MNXR123349 1 L-threonine product vacuole -L-threonine transport, vacuoluar 1 L-threonine reactant cytoplasm -L-threonine transport, vacuoluar 1 L-threonine product vacuole -MNXR123349 1 L-alanine product vacuole -MNXR118741 1 thymidine 3'-monophosphate reactant cytoplasm -MNXR118741 1 H2O reactant cytoplasm -MNXR118741 1 thymidine product cytoplasm -MNXR118741 1 phosphate product cytoplasm -thymidine 3'-monophosphate transport 1 thymidine 3'-monophosphate reactant extracellular -thymidine 3'-monophosphate transport 1 thymidine 3'-monophosphate product cytoplasm -nucleotide-specific phosphatase (thymidine 5'-monophosphate) 1 thymidine 5'-monophosphate reactant cytoplasm -nucleotide-specific phosphatase (thymidine 5'-monophosphate) 1 H2O reactant cytoplasm -nucleotide-specific phosphatase (thymidine 5'-monophosphate) 1 thymidine product cytoplasm -nucleotide-specific phosphatase (thymidine 5'-monophosphate) 1 phosphate product cytoplasm -thymidine 5'-monophosphate transport 1 thymidine 5'-monophosphate reactant extracellular -thymidine 5'-monophosphate transport 1 thymidine 5'-monophosphate product cytoplasm -RHEA:11477 1 glycerol 1-phosphate reactant cytoplasm -RHEA:11477 1 H2O reactant cytoplasm -RHEA:11477 1 glycerol product cytoplasm -RHEA:11477 1 phosphate product cytoplasm -glycerol 1-phosphate transport 1 glycerol 1-phosphate reactant extracellular -glycerol 1-phosphate transport 1 glycerol 1-phosphate product cytoplasm -MNXR137107 1 Ala-His reactant extracellular -MNXR137107 1 H+ reactant extracellular -MNXR137107 1 H+ product cytoplasm -MNXR137107 1 Ala-His product cytoplasm -MNXR137107_cv 1 H+ reactant cytoplasm -MNXR137107_cv 1 Ala-His reactant cytoplasm -MNXR137107_cv 1 H+ product vacuole -MNXR137107_cv 1 Ala-His product vacuole -MNXR123347 1 Ala-His reactant vacuole -MNXR123347 1 H2O reactant vacuole -MNXR123347 1 L-histidine product vacuole -MNXR123347 1 L-alanine product vacuole -Gly-Asn transport via proton symport (extracellular to cytosol) 1 Gly-Asn reactant extracellular -Gly-Asn transport via proton symport (extracellular to cytosol) 1 H+ reactant extracellular -Gly-Asn transport via proton symport (extracellular to cytosol) 1 H+ product cytoplasm -Gly-Asn transport via proton symport (extracellular to cytosol) 1 Gly-Asn product cytoplasm -Gly-Asn transport via proton symport (cytosol to vacuole) 1 H+ reactant cytoplasm -Gly-Asn transport via proton symport (cytosol to vacuole) 1 Gly-Asn reactant cytoplasm -Gly-Asn transport via proton symport (cytosol to vacuole) 1 H+ product vacuole -Gly-Asn transport via proton symport (cytosol to vacuole) 1 Gly-Asn product vacuole -MNXR123350 1 Gly-Asn reactant vacuole -MNXR123350 1 H2O reactant vacuole -MNXR123350 1 L-glycine product vacuole -MNXR123350 1 L-asparagine product vacuole -MNXR137074 1 Gly-Gln reactant extracellular -MNXR137074 1 H+ reactant extracellular -MNXR137074 1 H+ product cytoplasm -MNXR137074 1 Gly-Gln product cytoplasm -MNXR137074_cv 1 H+ reactant cytoplasm -MNXR137074_cv 1 Gly-Gln reactant cytoplasm -MNXR137074_cv 1 H+ product vacuole -MNXR137074_cv 1 Gly-Gln product vacuole -MNXR123351 1 Gly-Gln reactant vacuole -MNXR123351 1 H2O reactant vacuole -MNXR123351 1 L-glycine product vacuole -MNXR123351 1 L-glutamine product vacuole -Gly-Glu transport via proton symport (extracellular to cytosol) 1 Gly-Glu reactant extracellular -Gly-Glu transport via proton symport (extracellular to cytosol) 1 H+ reactant extracellular -Gly-Glu transport via proton symport (extracellular to cytosol) 1 H+ product cytoplasm -Gly-Glu transport via proton symport (extracellular to cytosol) 1 Gly-Glu product cytoplasm -Gly-Glu transport via proton symport (cytosol to vacuole) 1 H+ reactant cytoplasm -Gly-Glu transport via proton symport (cytosol to vacuole) 1 Gly-Glu reactant cytoplasm -Gly-Glu transport via proton symport (cytosol to vacuole) 1 H+ product vacuole -Gly-Glu transport via proton symport (cytosol to vacuole) 1 Gly-Glu product vacuole -MNXR123352 1 Gly-Glu reactant vacuole -MNXR123352 1 H2O reactant vacuole -MNXR123352 1 L-glycine product vacuole -MNXR123352 1 L-glutamate product vacuole -MNXR99852 1 glycerol 2-phosphate(2-) reactant cytoplasm -MNXR99852 1 H2O reactant cytoplasm -MNXR99852 1 glycerol product cytoplasm -MNXR99852 1 phosphate product cytoplasm -MNXR98598 1 glycerol 2-phosphate(2-) reactant extracellular -MNXR98598 1 glycerol 2-phosphate(2-) product cytoplasm -MNXR103332 1 O-phospho-L-threonine reactant cytoplasm -MNXR103332 1 H2O reactant cytoplasm -MNXR103332 1 phosphate product cytoplasm -MNXR103332 1 L-threonine product cytoplasm -MNXR136678 1 H+ reactant extracellular -MNXR136678 1 O-phospho-L-threonine reactant extracellular -MNXR136678 1 O-phospho-L-threonine product cytoplasm -MNXR136678 1 H+ product cytoplasm -MNXR118732 1 guanosine 2'-monophosphate reactant cytoplasm -MNXR118732 1 H2O reactant cytoplasm -MNXR118732 1 guanosine product cytoplasm -MNXR118732 1 phosphate product cytoplasm -Guanosine transport via proton symport 1 H+ reactant extracellular -Guanosine transport via proton symport 1 guanosine 2'-monophosphate reactant extracellular -Guanosine transport via proton symport 1 guanosine 2'-monophosphate product cytoplasm -Guanosine transport via proton symport 1 H+ product cytoplasm -MNXR94936 1 3'-GMP reactant cytoplasm -MNXR94936 1 H2O reactant cytoplasm -MNXR94936 1 guanosine product cytoplasm -MNXR94936 1 phosphate product cytoplasm -Guanosine transport via proton symport(for 3'-GMP) 1 H+ reactant extracellular -Guanosine transport via proton symport(for 3'-GMP) 1 3'-GMP reactant extracellular -Guanosine transport via proton symport(for 3'-GMP) 1 3'-GMP product cytoplasm -Guanosine transport via proton symport(for 3'-GMP) 1 H+ product cytoplasm -MNXR94822 1 H+ reactant extracellular -MNXR94822 1 2-phosphoglycolate reactant extracellular -MNXR94822 1 2-phosphoglycolate product cytoplasm -MNXR94822 1 H+ product cytoplasm -MNXR102543 1 2-phosphoglycolate reactant cytoplasm -MNXR102543 1 H2O reactant cytoplasm -MNXR102543 1 phosphate product cytoplasm -MNXR102543 1 glycolate product cytoplasm -MNXR118734 1 cysteamine S-phosphate reactant cytoplasm -MNXR118734 1 H2O reactant cytoplasm -MNXR118734 1 cysteamine product cytoplasm -MNXR137130 1 H+ reactant extracellular -MNXR137130 1 cysteamine reactant extracellular -MNXR137130 1 cysteamine product cytoplasm -cysteamine exchange 1 cysteamine reactant extracellular -MNXR137130 1 H+ product cytoplasm -MNXR118734 1 phosphate product cytoplasm -cysteamine S-phosphate transport via proton symport 1 cysteamine S-phosphate reactant extracellular -cysteamine S-phosphate transport via proton symport 1 cysteamine S-phosphate product cytoplasm -MNXR107528 1 cysteamine reactant cytoplasm -MNXR107528 1 oxygen reactant cytoplasm -MNXR107528 1 hypotaurine product cytoplasm -MNXR107528 1 H+ product cytoplasm -MNXR107116 1 hypotaurine reactant cytoplasm -MNXR107116 1 H2O reactant cytoplasm -MNXR107116 1 NAD reactant cytoplasm -MNXR107116 1 taurine product cytoplasm -MNXR107116 1 H+ product cytoplasm -MNXR107116 1 NADH product cytoplasm -MNXR103265 1 H2O reactant cytoplasm -MNXR103265 1 O-phosphonatooxy-D-serine(2-) reactant cytoplasm -MNXR103265 1 D-Serine product cytoplasm -MNXR103265 1 phosphate product cytoplasm -MNXR103244 1 O-phosphonatooxy-D-serine(2-) reactant extracellular -MNXR103244 1 H+ reactant extracellular -MNXR103244 1 H+ product cytoplasm -MNXR103244 1 O-phosphonatooxy-D-serine(2-) product cytoplasm -MNXR103594 1 2-oxobutanoate reactant cytoplasm -MNXR103594 1 L-glutamate reactant cytoplasm -MNXR103594 1 2-aminobutanoate product cytoplasm -MNXR103594 1 2-oxoglutarate product cytoplasm -2-aminobutyrate transport 1 H+ reactant extracellular -2-aminobutyrate transport 1 2-aminobutanoate reactant extracellular -2-aminobutyrate transport 1 2-aminobutanoate product cytoplasm -2-aminobutyrate transport 1 H+ product cytoplasm -MNXR118730 1 uridine 2'-phosphate reactant cytoplasm -MNXR118730 1 H2O reactant cytoplasm -MNXR118730 1 uridine product cytoplasm -MNXR118730 1 phosphate product cytoplasm -MNXR136675 1 H+ reactant extracellular -MNXR136675 1 uridine 2'-phosphate reactant extracellular -MNXR136675 1 uridine 2'-phosphate product cytoplasm -MNXR136675 1 H+ product cytoplasm -MNXR94932 1 3'-UMP reactant cytoplasm -MNXR94932 1 H2O reactant cytoplasm -MNXR94932 1 uridine product cytoplasm -MNXR94932 1 phosphate product cytoplasm -MNXR94982 1 H+ reactant extracellular -MNXR94982 1 3'-UMP reactant extracellular -MNXR94982 1 3'-UMP product cytoplasm -MNXR94982 1 H+ product cytoplasm -MNXR137072 1 Gly-Met reactant extracellular -MNXR137072 1 H+ reactant extracellular -MNXR137072 1 H+ product cytoplasm -MNXR137072 1 Gly-Met product cytoplasm -MNXR137072_cv 1 H+ reactant cytoplasm -MNXR137072_cv 1 Gly-Met reactant cytoplasm -MNXR137072_cv 1 H+ product vacuole -MNXR137072_cv 1 Gly-Met product vacuole -MNXR123343 1 Gly-Met reactant vacuole -MNXR123343 1 H2O reactant vacuole -MNXR123343 1 L-methionine product vacuole -MNXR123343 1 L-glycine product vacuole -MNXR111061 1 N-phosphocreatine reactant cytoplasm -MNXR111061 1 creatinine product cytoplasm -MNXR111061 1 phosphate product cytoplasm -N-phosphocreatine transport 1 H+ reactant extracellular -N-phosphocreatine transport 1 N-phosphocreatine reactant extracellular -N-phosphocreatine transport 1 N-phosphocreatine product cytoplasm -N-phosphocreatine transport 1 H+ product cytoplasm -creatinine transport 1 H+ reactant extracellular -creatinine transport 1 creatinine reactant extracellular -creatinine transport 1 creatinine product cytoplasm -creatinine transport 1 H+ product cytoplasm -MNXR95943 1 H+ reactant cytoplasm -MNXR95943 1 N(omega)-phospho-L-arginine reactant cytoplasm -MNXR95943 1 ADP reactant cytoplasm -MNXR95943 1 ATP product cytoplasm -MNXR95943 1 L-arginine product cytoplasm -MNXR95947 1 H+ reactant extracellular -MNXR95947 1 N(omega)-phospho-L-arginine reactant extracellular -MNXR95947 1 N(omega)-phospho-L-arginine product cytoplasm -MNXR95947 1 H+ product cytoplasm -MNXR117325 1 2',3'-cyclic GMP reactant cytoplasm -MNXR117325 1 H2O reactant cytoplasm -MNXR117325 1 H+ product cytoplasm -MNXR117325 1 guanosine 2'-monophosphate product cytoplasm -MNXR94721 1 2',3'-cyclic GMP reactant extracellular -MNXR94721 1 2',3'-cyclic GMP product cytoplasm -MNXR104998 1 H2O reactant cytoplasm -MNXR104998 1 O(4)-phospho-L-tyrosine reactant cytoplasm -MNXR104998 1 L-tyrosine product cytoplasm -MNXR104998 1 phosphate product cytoplasm -MNXR137095 1 H+ reactant extracellular -MNXR137095 1 O(4)-phospho-L-tyrosine reactant extracellular -MNXR137095 1 O(4)-phospho-L-tyrosine product cytoplasm -MNXR137095 1 H+ product cytoplasm -MNXR103069 1 triphosphate reactant cytoplasm -MNXR103069 1 H2O reactant cytoplasm -MNXR103069 1 phosphate product cytoplasm -MNXR103069 1 diphosphate product cytoplasm -MNXR135003 1 H+ reactant extracellular -MNXR135003 1 triphosphate reactant extracellular -MNXR135003 1 triphosphate product cytoplasm -MNXR135003 1 H+ product cytoplasm -MNXR118731 1 cytidine 2'-phosphate reactant cytoplasm -MNXR118731 1 H2O reactant cytoplasm -MNXR118731 1 cytidine product cytoplasm -MNXR118731 1 phosphate product cytoplasm -MNXR135010 1 H+ reactant extracellular -MNXR135010 1 cytidine 2'-phosphate reactant extracellular -MNXR135010 1 cytidine 2'-phosphate product cytoplasm -MNXR135010 1 H+ product cytoplasm -MNXR117327 1 2',3'-cyclic UMP reactant cytoplasm -MNXR117327 1 H2O reactant cytoplasm -MNXR117327 1 uridine 2'-phosphate product cytoplasm -MNXR117327 1 H+ product cytoplasm -MNXR136674 1 H+ reactant extracellular -MNXR136674 1 2',3'-cyclic UMP reactant extracellular -MNXR136674 1 2',3'-cyclic UMP product cytoplasm -MNXR136674 1 H+ product cytoplasm -MNXR123155 1 3-sulfino-L-alanine reactant cytoplasm -MNXR123155 1 H2O reactant cytoplasm -MNXR123155 1 L-alanine product cytoplasm -MNXR123155 1 sulphite product cytoplasm -MNXR137086 1 H+ reactant extracellular -MNXR137086 1 3-sulfino-L-alanine reactant extracellular -MNXR137086 1 3-sulfino-L-alanine product cytoplasm -MNXR137086 1 H+ product cytoplasm -MNXR94935 1 3'-AMP reactant cytoplasm -MNXR94935 1 H2O reactant cytoplasm -MNXR94935 1 adenosine product cytoplasm -MNXR94935 1 phosphate product cytoplasm -MNXR94857 1 3'-AMP reactant extracellular -MNXR94857 1 3'-AMP product cytoplasm -MNXR130717 1 6-O-alpha-D-glucopyranosyl-D-fructofuranose reactant cytoplasm -MNXR130717 1 H2O reactant cytoplasm -MNXR130717 1 D-fructose product cytoplasm -MNXR130717 1 D-glucose product cytoplasm -MNXR102339 1 H+ reactant extracellular -MNXR102339 1 6-O-alpha-D-glucopyranosyl-D-fructofuranose reactant extracellular -MNXR102339 1 6-O-alpha-D-glucopyranosyl-D-fructofuranose product cytoplasm -MNXR102339 1 H+ product cytoplasm -MNXR103637 1 N-acetyl-L-cysteine reactant cytoplasm -MNXR103637 1 coenzyme A reactant cytoplasm -MNXR103637 1 H+ reactant cytoplasm -MNXR103637 1 acetyl-CoA product cytoplasm -MNXR103637 1 L-cysteine product cytoplasm -MNXR137052 1 H+ reactant extracellular -MNXR137052 1 N-acetyl-L-cysteine reactant extracellular -MNXR137052 1 N-acetyl-L-cysteine product cytoplasm -MNXR137052 1 H+ product cytoplasm -MNXR106345 1 tetrathionate reactant cytoplasm -MNXR106345 2 ferricytochrome c reactant mitochondrion -MNXR106345 2 thiosulfate product cytoplasm -MNXR106345 2 ferrocytochrome c product mitochondrion -MNXR104796 1 tetrathionate reactant extracellular -MNXR104796 1 tetrathionate product cytoplasm -L-methionine transport, vacuoluar 1 L-methionine reactant cytoplasm -L-methionine transport, vacuoluar 1 L-methionine product vacuole -MNXR99485 1 2-hydroxyethane-1-sulfonate reactant cytoplasm -MNXR99485 1 FMNH2 reactant cytoplasm -MNXR99485 1 oxygen reactant cytoplasm -MNXR99485 1 H+ product cytoplasm -MNXR99485 1 sulphite product cytoplasm -MNXR99485 1 H2O product cytoplasm -MNXR99485 1 FMN product cytoplasm -MNXR99485 1 glycolaldehyde product cytoplasm -MNXR137058 1 H+ reactant extracellular -MNXR137058 1 2-hydroxyethane-1-sulfonate reactant extracellular -MNXR137058 1 2-hydroxyethane-1-sulfonate product cytoplasm -MNXR137058 1 H+ product cytoplasm -MNXR95065 1 H+ reactant cytoplasm -MNXR95065 1 NADPH reactant cytoplasm -MNXR95065 1 5-dehydro-D-gluconate reactant cytoplasm -MNXR95065 1 D-gluconate product cytoplasm -MNXR95065 1 NADP(+) product cytoplasm -MNXR95066 1 H+ reactant extracellular -MNXR95066 1 5-dehydro-D-gluconate reactant extracellular -MNXR95066 1 5-dehydro-D-gluconate product cytoplasm -MNXR95066 1 H+ product cytoplasm -MNXR137135 1 Ala-Asp reactant extracellular -MNXR137135 1 H+ reactant extracellular -MNXR137135 1 H+ product cytoplasm -MNXR137135 1 Ala-Asp product cytoplasm -MNXR137135_cv 1 H+ reactant cytoplasm -MNXR137135_cv 1 Ala-Asp reactant cytoplasm -MNXR137135_cv 1 H+ product vacuole -MNXR137135_cv 1 Ala-Asp product vacuole -MNXR123344 1 Ala-Asp reactant vacuole -MNXR123344 1 H2O reactant vacuole -MNXR123344 1 L-alanine product vacuole -MNXR123344 1 L-aspartate product vacuole -MNXR96247 1 methyl alpha-D-glucopyranoside reactant cytoplasm -MNXR96247 1 H2O reactant cytoplasm -MNXR96247 1 D-glucose product cytoplasm -MNXR96247 1 methanol product cytoplasm -MNXR101464 1 methanol reactant cytoplasm -MNXR101464 1 methanol product extracellular -MNXR98748 1 methanol reactant extracellular -MNXR137048 1 H+ reactant extracellular -MNXR137048 1 methyl alpha-D-glucopyranoside reactant extracellular -MNXR137048 1 methyl alpha-D-glucopyranoside product cytoplasm -MNXR137048 1 H+ product cytoplasm -MNXR117326 1 2',3'-cyclic CMP reactant cytoplasm -MNXR117326 1 H2O reactant cytoplasm -MNXR117326 1 cytidine 2'-phosphate product cytoplasm -MNXR117326 1 H+ product cytoplasm -MNXR136673 1 H+ reactant extracellular -MNXR136673 1 2',3'-cyclic CMP reactant extracellular -MNXR136673 1 2',3'-cyclic CMP product cytoplasm -MNXR136673 1 H+ product cytoplasm -MNXR107830 1 D-tagatose reactant cytoplasm -MNXR107830 1 ATP reactant cytoplasm -MNXR107830 1 ADP product cytoplasm -MNXR107830 1 D-tagatofuranose 6-phosphate product cytoplasm -MNXR107830 1 H+ product cytoplasm -R11623 1 D-tagatofuranose 6-phosphate reactant cytoplasm -R11623 1 D-fructose 6-phosphate product cytoplasm -MNXR104707 1 D-tagatose reactant extracellular -MNXR104707 1 D-tagatose product cytoplasm -MNXR130716 1 turanose reactant extracellular -MNXR130716 1 H2O reactant extracellular -MNXR130716 1 D-fructose product extracellular -MNXR130716 1 D-glucose product extracellular -MNXR95136 1 acetoacetate reactant cytoplasm -MNXR95136 1 ATP reactant cytoplasm -MNXR95136 1 coenzyme A reactant cytoplasm -MNXR95136 1 AMP product cytoplasm -MNXR95136 1 diphosphate product cytoplasm -MNXR95136 1 acetoacetyl-CoA product cytoplasm -MNXR95208 1 acetoacetate reactant extracellular -MNXR95208 1 acetoacetate product cytoplasm -MNXR103709 1 N(alpha)-acetyl-L-methionine reactant cytoplasm -MNXR103709 1 H2O reactant cytoplasm -MNXR103709 1 acetate product cytoplasm -MNXR103709 1 L-methionine product cytoplasm -MNXR137089 1 H+ reactant extracellular -MNXR137089 1 N(alpha)-acetyl-L-methionine reactant extracellular -MNXR137089 1 N(alpha)-acetyl-L-methionine product cytoplasm -MNXR137089 1 H+ product cytoplasm -MNXR106549 1 3-oxalomalate(3-) reactant cytoplasm -MNXR106549 1 oxaloacetate product cytoplasm -MNXR106549 1 glyoxylate product cytoplasm -MNXR137067 1 H+ reactant extracellular -MNXR137067 1 3-oxalomalate(3-) reactant extracellular -MNXR137067 1 3-oxalomalate(3-) product cytoplasm -MNXR137067 1 H+ product cytoplasm -MNXR111236 1 L-cysteate reactant cytoplasm -MNXR111236 1 H2O reactant cytoplasm -MNXR111236 1 pyruvate product cytoplasm -MNXR111236 1 ammonium product cytoplasm -MNXR111236 1 sulphite product cytoplasm -MNXR124424 1 H+ reactant extracellular -MNXR124424 1 L-cysteate reactant extracellular -MNXR124424 1 L-cysteate product cytoplasm -MNXR124424 1 H+ product cytoplasm -MNXR101619 1 alpha-maltotriose reactant extracellular -MNXR101619 1 H2O reactant extracellular -MNXR101619 1 maltose product extracellular -MNXR101619 1 D-glucose product extracellular -MNXR94824 1 H+ reactant extracellular -MNXR94824 1 2-phospho-D-glyceric acid reactant extracellular -MNXR94824 1 2-phospho-D-glyceric acid product cytoplasm -MNXR94824 1 H+ product cytoplasm -MNXR94973 1 H+ reactant extracellular -MNXR94973 1 3-phosphonato-D-glycerate(3-) reactant extracellular -MNXR94973 1 3-phosphonato-D-glycerate(3-) product cytoplasm -MNXR94973 1 H+ product cytoplasm -Met-Ala transport via proton symport (extracellular to cytosol) 1 Met-Ala reactant extracellular -Met-Ala transport via proton symport (extracellular to cytosol) 1 H+ reactant extracellular -Met-Ala transport via proton symport (extracellular to cytosol) 1 H+ product cytoplasm -Met-Ala transport via proton symport (extracellular to cytosol) 1 Met-Ala product cytoplasm -Met-Ala transport via proton symport (cytosol to vacuole) 1 H+ reactant cytoplasm -Met-Ala transport via proton symport (cytosol to vacuole) 1 Met-Ala reactant cytoplasm -Met-Ala transport via proton symport (cytosol to vacuole) 1 H+ product vacuole -Met-Ala transport via proton symport (cytosol to vacuole) 1 Met-Ala product vacuole -MNXR99849 1 D-glucose 1-phosphate reactant extracellular -MNXR99849 1 D-glucose 1-phosphate product cytoplasm -MNXR96488 1 carbamoyl phosphate reactant extracellular -MNXR96488 1 carbamoyl phosphate product cytoplasm -MNXR103245 1 3-phospho-serine reactant extracellular -MNXR103245 1 H+ reactant extracellular -MNXR103245 1 H+ product cytoplasm -MNXR103245 1 3-phospho-serine product cytoplasm -MNXR100385 1 GMP reactant extracellular -MNXR100385 1 H+ reactant extracellular -MNXR100385 1 H+ product cytoplasm -MNXR100385 1 GMP product cytoplasm -MNXR101585 1 myo-inositol hexakisphosphate reactant extracellular -MNXR101585 1 myo-inositol hexakisphosphate product cytoplasm -MNXR98531 1 D-glucose 6-phosphate reactant extracellular -MNXR98531 1 D-glucose 6-phosphate product cytoplasm -MNXR105127 1 UMP reactant extracellular -MNXR105127 1 UMP product cytoplasm -MNXR102493 1 phosphoenolpyruvate reactant extracellular -MNXR102493 1 H+ reactant extracellular -MNXR102493 1 H+ product cytoplasm -MNXR102493 1 phosphoenolpyruvate product cytoplasm -MNXR101385 1 D-mannose 6-phosphate reactant extracellular -MNXR101385 1 D-mannose 6-phosphate product cytoplasm -MNXR135002 1 O-phosphoethanolamine reactant extracellular -MNXR135002 1 H+ reactant extracellular -MNXR135002 1 H+ product cytoplasm -MNXR135002 1 O-phosphoethanolamine product cytoplasm -MNXR95102 1 6-phospho-D-gluconate reactant extracellular -MNXR95102 1 H+ reactant extracellular -MNXR95102 1 H+ product cytoplasm -MNXR95102 1 6-phospho-D-gluconate product cytoplasm -MNXR101377 1 D-mannose 1-phosphate reactant extracellular -MNXR101377 1 H+ reactant extracellular -MNXR101377 1 H+ product cytoplasm -MNXR101377 1 D-mannose 1-phosphate product cytoplasm -MNXR136667 1 diphosphate reactant extracellular -MNXR136667 2 H+ reactant extracellular -MNXR136667 2 H+ product cytoplasm -MNXR136667 1 diphosphate product cytoplasm -MNXR96703 1 choline phosphate reactant extracellular -MNXR96703 1 choline phosphate product cytoplasm -MNXR104966 1 thiosulfate reactant extracellular -MNXR104966 1 thiosulfate product cytoplasm -MNXR95831 1 AMP reactant extracellular -MNXR95831 1 H+ reactant extracellular -MNXR95831 1 H+ product cytoplasm -MNXR95831 1 AMP product cytoplasm -MNXR94718 1 2',3'-cyclic AMP reactant extracellular -MNXR94718 1 2',3'-cyclic AMP product cytoplasm -MNXR135007 1 adenosine 2'-phosphate reactant extracellular -MNXR135007 1 H+ reactant extracellular -MNXR135007 1 H+ product cytoplasm -MNXR135007 1 adenosine 2'-phosphate product cytoplasm -MNXR96805 1 CMP reactant extracellular -MNXR96805 1 H+ reactant extracellular -MNXR96805 1 H+ product cytoplasm -MNXR96805 1 CMP product cytoplasm -MNXR100035 1 D-Glucosamine reactant extracellular -MNXR100035 1 D-Glucosamine product cytoplasm -2-deoxy-D-ribose transport 1 2-deoxy-D-ribose reactant extracellular -2-deoxy-D-ribose transport 1 2-deoxy-D-ribose product cytoplasm -MNXR96737 1 L-citrulline reactant extracellular -MNXR96737 1 H+ reactant extracellular -MNXR96737 1 H+ product cytoplasm -MNXR96737 1 L-citrulline product cytoplasm -MNXR97367 1 glycerone reactant extracellular -MNXR97367 1 glycerone product cytoplasm -Ala-Leu transport via proton symport (extracellular to cytosol) 1 Ala-Leu reactant extracellular -Ala-Leu transport via proton symport (extracellular to cytosol) 1 H+ reactant extracellular -Ala-Leu transport via proton symport (extracellular to cytosol) 1 H+ product cytoplasm -Ala-Leu transport via proton symport (extracellular to cytosol) 1 Ala-Leu product cytoplasm -Ala-Leu transport via proton symport (cytosol to vacuole) 1 H+ reactant cytoplasm -Ala-Leu transport via proton symport (cytosol to vacuole) 1 Ala-Leu reactant cytoplasm -Ala-Leu transport via proton symport (cytosol to vacuole) 1 H+ product vacuole -Ala-Leu transport via proton symport (cytosol to vacuole) 1 Ala-Leu product vacuole -MNXR137133 1 Ala-Gly reactant extracellular -MNXR137133 1 H+ reactant extracellular -MNXR137133 1 H+ product cytoplasm -MNXR137133 1 Ala-Gly product cytoplasm -MNXR137133_cv 1 H+ reactant cytoplasm -MNXR137133_cv 1 Ala-Gly reactant cytoplasm -MNXR137133_cv 1 H+ product vacuole -MNXR137133_cv 1 Ala-Gly product vacuole -N-acetyl-L-glutamate transport 1 N-acetyl-L-glutamate reactant extracellular -N-acetyl-L-glutamate transport 1 N-acetyl-L-glutamate product cytoplasm -N-acetyl-L-glutamate transport, mitochondrion 1 N-acetyl-L-glutamate reactant cytoplasm -N-acetyl-L-glutamate transport, mitochondrion 1 N-acetyl-L-glutamate product mitochondrion -MNXR137094 1 lipoamide reactant extracellular -MNXR137094 1 H+ reactant extracellular -MNXR137094 1 H+ product cytoplasm -MNXR137094 1 lipoamide product cytoplasm -MNXR101483 1 L-Methionine S-oxide reactant extracellular -MNXR101483 1 L-Methionine S-oxide product cytoplasm -Hydrogen sulfide oxidation 1 hydrogen sulfide reactant cytoplasm -Hydrogen sulfide oxidation 2 oxygen reactant cytoplasm -Hydrogen sulfide oxidation 1 H+ product cytoplasm -Hydrogen sulfide oxidation 1 sulphate product cytoplasm -MNXR95704 1 H+ reactant cytoplasm -MNXR95704 1 L-alanine reactant cytoplasm -MNXR95704 1 L-alanine product vacuole -MNXR95704 1 H+ product vacuole -MNXR100368 1 H+ reactant cytoplasm -MNXR100368 1 L-glycine reactant cytoplasm -MNXR100368 1 L-glycine product vacuole -MNXR100368 1 H+ product vacuole -MNXR104382 1 O-succinyl-L-homoserine reactant cytoplasm -MNXR104382 1 hydrogen sulfide reactant cytoplasm -MNXR104382 1 L-homocysteine product cytoplasm -MNXR104382 1 succinate product cytoplasm -MNXR94843 1 oxygen reactant cytoplasm -MNXR94843 1 3-(4-hydroxyphenyl)pyruvate reactant cytoplasm -MNXR94843 1 homogentisate product cytoplasm -MNXR94843 1 carbon dioxide product cytoplasm -MNXR100628 1 homogentisate reactant cytoplasm -MNXR100628 1 oxygen reactant cytoplasm -MNXR100628 1 4-maleylacetoacetate product cytoplasm -MNXR100628 1 H+ product cytoplasm -MNXR101325 1 4-maleylacetoacetate reactant cytoplasm -MNXR101325 1 4-fumarylacetoacetate product cytoplasm -MNXR99706 1 4-fumarylacetoacetate reactant cytoplasm -MNXR99706 1 H2O reactant cytoplasm -MNXR99706 1 fumarate product cytoplasm -MNXR99706 1 acetoacetate product cytoplasm -MNXR99706 1 H+ product cytoplasm -MNXR95187 1 L-arabinitol reactant cytoplasm -MNXR95187 1 NAD reactant cytoplasm -MNXR95187 1 H+ product cytoplasm -MNXR95187 1 NADH product cytoplasm -MNXR95187 1 L-xylulose product cytoplasm -MNXR105265 1 L-xylulose reactant cytoplasm -MNXR105265 1 NADPH reactant cytoplasm -MNXR105265 1 H+ reactant cytoplasm -MNXR105265 1 xylitol product cytoplasm -MNXR105265 1 NADP(+) product cytoplasm -arabinose reductase (D-arabinose) 1 D-arabinose reactant cytoplasm -arabinose reductase (D-arabinose) 1 NADPH reactant cytoplasm -arabinose reductase (D-arabinose) 1 H+ reactant cytoplasm -arabinose reductase (D-arabinose) 1 D-arabinitol product cytoplasm -arabinose reductase (D-arabinose) 1 NADP(+) product cytoplasm -MNXR95188 1 D-arabinitol reactant cytoplasm -MNXR95188 1 NAD reactant cytoplasm -MNXR95188 1 H+ product cytoplasm -MNXR95188 1 NADH product cytoplasm -MNXR95188 1 D-xylulose product cytoplasm -MNXR118733 1 adenosine 2'-phosphate reactant cytoplasm -MNXR118733 1 H2O reactant cytoplasm -MNXR118733 1 adenosine product cytoplasm -MNXR118733 1 phosphate product cytoplasm +rxnID coefficient Metabolite standard name Metabolite_type compartment +MNXR137087 1 Ala-Gln reactant extracellular +MNXR137087 1 H+ reactant extracellular +MNXR137087 1 H+ product cytoplasm +MNXR137087 1 Ala-Gln product cytoplasm +MNXR137087_cv 1 H+ reactant cytoplasm +MNXR137087_cv 1 Ala-Gln reactant cytoplasm +MNXR137087_cv 1 H+ product vacuole +MNXR137087_cv 1 Ala-Gln product vacuole +MNXR123345 1 Ala-Gln reactant vacuole +MNXR123345 1 H2O reactant vacuole +MNXR123345 1 L-glutamine product vacuole +MNXR123345 1 L-alanine product vacuole +MNXR101006 1 Ala-Glu reactant extracellular +MNXR101006 1 H+ reactant extracellular +MNXR101006 1 H+ product cytoplasm +MNXR101006 1 Ala-Glu product cytoplasm +MNXR101006_cv 1 H+ reactant cytoplasm +MNXR101006_cv 1 Ala-Glu reactant cytoplasm +MNXR101006_cv 1 H+ product vacuole +MNXR101006_cv 1 Ala-Glu product vacuole +MNXR101011 1 Ala-Glu reactant vacuole +MNXR101011 1 H2O reactant vacuole +MNXR101011 1 L-glutamate product vacuole +MNXR101011 1 L-alanine product vacuole +Ala-Thr transport via proton symport (extracellular to cytosol) 1 Ala-Thr reactant extracellular +Ala-Thr transport via proton symport (extracellular to cytosol) 1 H+ reactant extracellular +Ala-Thr transport via proton symport (extracellular to cytosol) 1 H+ product cytoplasm +Ala-Thr transport via proton symport (extracellular to cytosol) 1 Ala-Thr product cytoplasm +Ala-Thr transport via proton symport (cytosol to vacuole) 1 H+ reactant cytoplasm +Ala-Thr transport via proton symport (cytosol to vacuole) 1 Ala-Thr reactant cytoplasm +Ala-Thr transport via proton symport (cytosol to vacuole) 1 H+ product vacuole +Ala-Thr transport via proton symport (cytosol to vacuole) 1 Ala-Thr product vacuole +MNXR123349 1 Ala-Thr reactant vacuole +MNXR123349 1 H2O reactant vacuole +MNXR123349 1 L-threonine product vacuole +L-threonine transport, vacuoluar 1 L-threonine reactant cytoplasm +L-threonine transport, vacuoluar 1 L-threonine product vacuole +MNXR123349 1 L-alanine product vacuole +MNXR118741 1 thymidine 3'-monophosphate reactant cytoplasm +MNXR118741 1 H2O reactant cytoplasm +MNXR118741 1 thymidine product cytoplasm +MNXR118741 1 phosphate product cytoplasm +thymidine 3'-monophosphate transport 1 thymidine 3'-monophosphate reactant extracellular +thymidine 3'-monophosphate transport 1 thymidine 3'-monophosphate product cytoplasm +nucleotide-specific phosphatase (thymidine 5'-monophosphate) 1 thymidine 5'-monophosphate reactant cytoplasm +nucleotide-specific phosphatase (thymidine 5'-monophosphate) 1 H2O reactant cytoplasm +nucleotide-specific phosphatase (thymidine 5'-monophosphate) 1 thymidine product cytoplasm +nucleotide-specific phosphatase (thymidine 5'-monophosphate) 1 phosphate product cytoplasm +thymidine 5'-monophosphate transport 1 thymidine 5'-monophosphate reactant extracellular +thymidine 5'-monophosphate transport 1 thymidine 5'-monophosphate product cytoplasm +RHEA:11477 1 glycerol 1-phosphate reactant cytoplasm +RHEA:11477 1 H2O reactant cytoplasm +RHEA:11477 1 glycerol product cytoplasm +RHEA:11477 1 phosphate product cytoplasm +glycerol 1-phosphate transport 1 glycerol 1-phosphate reactant extracellular +glycerol 1-phosphate transport 1 glycerol 1-phosphate product cytoplasm +MNXR137107 1 Ala-His reactant extracellular +MNXR137107 1 H+ reactant extracellular +MNXR137107 1 H+ product cytoplasm +MNXR137107 1 Ala-His product cytoplasm +MNXR137107_cv 1 H+ reactant cytoplasm +MNXR137107_cv 1 Ala-His reactant cytoplasm +MNXR137107_cv 1 H+ product vacuole +MNXR137107_cv 1 Ala-His product vacuole +MNXR123347 1 Ala-His reactant vacuole +MNXR123347 1 H2O reactant vacuole +MNXR123347 1 L-histidine product vacuole +MNXR123347 1 L-alanine product vacuole +Gly-Asn transport via proton symport (extracellular to cytosol) 1 Gly-Asn reactant extracellular +Gly-Asn transport via proton symport (extracellular to cytosol) 1 H+ reactant extracellular +Gly-Asn transport via proton symport (extracellular to cytosol) 1 H+ product cytoplasm +Gly-Asn transport via proton symport (extracellular to cytosol) 1 Gly-Asn product cytoplasm +Gly-Asn transport via proton symport (cytosol to vacuole) 1 H+ reactant cytoplasm +Gly-Asn transport via proton symport (cytosol to vacuole) 1 Gly-Asn reactant cytoplasm +Gly-Asn transport via proton symport (cytosol to vacuole) 1 H+ product vacuole +Gly-Asn transport via proton symport (cytosol to vacuole) 1 Gly-Asn product vacuole +MNXR123350 1 Gly-Asn reactant vacuole +MNXR123350 1 H2O reactant vacuole +MNXR123350 1 L-glycine product vacuole +MNXR123350 1 L-asparagine product vacuole +MNXR137074 1 Gly-Gln reactant extracellular +MNXR137074 1 H+ reactant extracellular +MNXR137074 1 H+ product cytoplasm +MNXR137074 1 Gly-Gln product cytoplasm +MNXR137074_cv 1 H+ reactant cytoplasm +MNXR137074_cv 1 Gly-Gln reactant cytoplasm +MNXR137074_cv 1 H+ product vacuole +MNXR137074_cv 1 Gly-Gln product vacuole +MNXR123351 1 Gly-Gln reactant vacuole +MNXR123351 1 H2O reactant vacuole +MNXR123351 1 L-glycine product vacuole +MNXR123351 1 L-glutamine product vacuole +Gly-Glu transport via proton symport (extracellular to cytosol) 1 Gly-Glu reactant extracellular +Gly-Glu transport via proton symport (extracellular to cytosol) 1 H+ reactant extracellular +Gly-Glu transport via proton symport (extracellular to cytosol) 1 H+ product cytoplasm +Gly-Glu transport via proton symport (extracellular to cytosol) 1 Gly-Glu product cytoplasm +Gly-Glu transport via proton symport (cytosol to vacuole) 1 H+ reactant cytoplasm +Gly-Glu transport via proton symport (cytosol to vacuole) 1 Gly-Glu reactant cytoplasm +Gly-Glu transport via proton symport (cytosol to vacuole) 1 H+ product vacuole +Gly-Glu transport via proton symport (cytosol to vacuole) 1 Gly-Glu product vacuole +MNXR123352 1 Gly-Glu reactant vacuole +MNXR123352 1 H2O reactant vacuole +MNXR123352 1 L-glycine product vacuole +MNXR123352 1 L-glutamate product vacuole +MNXR99852 1 glycerol 2-phosphate(2-) reactant cytoplasm +MNXR99852 1 H2O reactant cytoplasm +MNXR99852 1 glycerol product cytoplasm +MNXR99852 1 phosphate product cytoplasm +MNXR98598 1 glycerol 2-phosphate(2-) reactant extracellular +MNXR98598 1 glycerol 2-phosphate(2-) product cytoplasm +MNXR103332 1 O-phospho-L-threonine reactant cytoplasm +MNXR103332 1 H2O reactant cytoplasm +MNXR103332 1 phosphate product cytoplasm +MNXR103332 1 L-threonine product cytoplasm +MNXR136678 1 H+ reactant extracellular +MNXR136678 1 O-phospho-L-threonine reactant extracellular +MNXR136678 1 O-phospho-L-threonine product cytoplasm +MNXR136678 1 H+ product cytoplasm +MNXR118732 1 guanosine 2'-monophosphate reactant cytoplasm +MNXR118732 1 H2O reactant cytoplasm +MNXR118732 1 guanosine product cytoplasm +MNXR118732 1 phosphate product cytoplasm +Guanosine transport via proton symport 1 H+ reactant extracellular +Guanosine transport via proton symport 1 guanosine 2'-monophosphate reactant extracellular +Guanosine transport via proton symport 1 guanosine 2'-monophosphate product cytoplasm +Guanosine transport via proton symport 1 H+ product cytoplasm +MNXR94936 1 3'-GMP reactant cytoplasm +MNXR94936 1 H2O reactant cytoplasm +MNXR94936 1 guanosine product cytoplasm +MNXR94936 1 phosphate product cytoplasm +Guanosine transport via proton symport(for 3'-GMP) 1 H+ reactant extracellular +Guanosine transport via proton symport(for 3'-GMP) 1 3'-GMP reactant extracellular +Guanosine transport via proton symport(for 3'-GMP) 1 3'-GMP product cytoplasm +Guanosine transport via proton symport(for 3'-GMP) 1 H+ product cytoplasm +MNXR94822 1 H+ reactant extracellular +MNXR94822 1 2-phosphoglycolate reactant extracellular +MNXR94822 1 2-phosphoglycolate product cytoplasm +MNXR94822 1 H+ product cytoplasm +MNXR102543 1 2-phosphoglycolate reactant cytoplasm +MNXR102543 1 H2O reactant cytoplasm +MNXR102543 1 phosphate product cytoplasm +MNXR102543 1 glycolate product cytoplasm +MNXR118734 1 cysteamine S-phosphate reactant cytoplasm +MNXR118734 1 H2O reactant cytoplasm +MNXR118734 1 cysteamine product cytoplasm +MNXR137130 1 H+ reactant extracellular +MNXR137130 1 cysteamine reactant extracellular +MNXR137130 1 cysteamine product cytoplasm +cysteamine exchange 1 cysteamine reactant extracellular +MNXR137130 1 H+ product cytoplasm +MNXR118734 1 phosphate product cytoplasm +cysteamine S-phosphate transport via proton symport 1 cysteamine S-phosphate reactant extracellular +cysteamine S-phosphate transport via proton symport 1 cysteamine S-phosphate product cytoplasm +MNXR107528 1 cysteamine reactant cytoplasm +MNXR107528 1 oxygen reactant cytoplasm +MNXR107528 1 hypotaurine product cytoplasm +MNXR107528 1 H+ product cytoplasm +MNXR107116 1 hypotaurine reactant cytoplasm +MNXR107116 1 H2O reactant cytoplasm +MNXR107116 1 NAD reactant cytoplasm +MNXR107116 1 taurine product cytoplasm +MNXR107116 1 H+ product cytoplasm +MNXR107116 1 NADH product cytoplasm +MNXR103265 1 H2O reactant cytoplasm +MNXR103265 1 O-phosphonatooxy-D-serine(2-) reactant cytoplasm +MNXR103265 1 D-Serine product cytoplasm +MNXR103265 1 phosphate product cytoplasm +MNXR103244 1 O-phosphonatooxy-D-serine(2-) reactant extracellular +MNXR103244 1 H+ reactant extracellular +MNXR103244 1 H+ product cytoplasm +MNXR103244 1 O-phosphonatooxy-D-serine(2-) product cytoplasm +MNXR103594 1 2-oxobutanoate reactant cytoplasm +MNXR103594 1 L-glutamate reactant cytoplasm +MNXR103594 1 2-aminobutanoate product cytoplasm +MNXR103594 1 2-oxoglutarate product cytoplasm +2-aminobutyrate transport 1 H+ reactant extracellular +2-aminobutyrate transport 1 2-aminobutanoate reactant extracellular +2-aminobutyrate transport 1 2-aminobutanoate product cytoplasm +2-aminobutyrate transport 1 H+ product cytoplasm +MNXR118730 1 uridine 2'-phosphate reactant cytoplasm +MNXR118730 1 H2O reactant cytoplasm +MNXR118730 1 uridine product cytoplasm +MNXR118730 1 phosphate product cytoplasm +MNXR136675 1 H+ reactant extracellular +MNXR136675 1 uridine 2'-phosphate reactant extracellular +MNXR136675 1 uridine 2'-phosphate product cytoplasm +MNXR136675 1 H+ product cytoplasm +MNXR94932 1 3'-UMP reactant cytoplasm +MNXR94932 1 H2O reactant cytoplasm +MNXR94932 1 uridine product cytoplasm +MNXR94932 1 phosphate product cytoplasm +MNXR94982 1 H+ reactant extracellular +MNXR94982 1 3'-UMP reactant extracellular +MNXR94982 1 3'-UMP product cytoplasm +MNXR94982 1 H+ product cytoplasm +MNXR137072 1 Gly-Met reactant extracellular +MNXR137072 1 H+ reactant extracellular +MNXR137072 1 H+ product cytoplasm +MNXR137072 1 Gly-Met product cytoplasm +MNXR137072_cv 1 H+ reactant cytoplasm +MNXR137072_cv 1 Gly-Met reactant cytoplasm +MNXR137072_cv 1 H+ product vacuole +MNXR137072_cv 1 Gly-Met product vacuole +MNXR123343 1 Gly-Met reactant vacuole +MNXR123343 1 H2O reactant vacuole +MNXR123343 1 L-methionine product vacuole +MNXR123343 1 L-glycine product vacuole +MNXR111061 1 N-phosphocreatine reactant cytoplasm +MNXR111061 1 creatinine product cytoplasm +MNXR111061 1 phosphate product cytoplasm +N-phosphocreatine transport 1 H+ reactant extracellular +N-phosphocreatine transport 1 N-phosphocreatine reactant extracellular +N-phosphocreatine transport 1 N-phosphocreatine product cytoplasm +N-phosphocreatine transport 1 H+ product cytoplasm +creatinine transport 1 H+ reactant extracellular +creatinine transport 1 creatinine reactant extracellular +creatinine transport 1 creatinine product cytoplasm +creatinine transport 1 H+ product cytoplasm +MNXR95943 1 H+ reactant cytoplasm +MNXR95943 1 N(omega)-phospho-L-arginine reactant cytoplasm +MNXR95943 1 ADP reactant cytoplasm +MNXR95943 1 ATP product cytoplasm +MNXR95943 1 L-arginine product cytoplasm +MNXR95947 1 H+ reactant extracellular +MNXR95947 1 N(omega)-phospho-L-arginine reactant extracellular +MNXR95947 1 N(omega)-phospho-L-arginine product cytoplasm +MNXR95947 1 H+ product cytoplasm +MNXR117325 1 2',3'-cyclic GMP reactant cytoplasm +MNXR117325 1 H2O reactant cytoplasm +MNXR117325 1 H+ product cytoplasm +MNXR117325 1 guanosine 2'-monophosphate product cytoplasm +MNXR94721 1 2',3'-cyclic GMP reactant extracellular +MNXR94721 1 2',3'-cyclic GMP product cytoplasm +MNXR104998 1 H2O reactant cytoplasm +MNXR104998 1 O(4)-phospho-L-tyrosine reactant cytoplasm +MNXR104998 1 L-tyrosine product cytoplasm +MNXR104998 1 phosphate product cytoplasm +MNXR137095 1 H+ reactant extracellular +MNXR137095 1 O(4)-phospho-L-tyrosine reactant extracellular +MNXR137095 1 O(4)-phospho-L-tyrosine product cytoplasm +MNXR137095 1 H+ product cytoplasm +MNXR103069 1 triphosphate reactant cytoplasm +MNXR103069 1 H2O reactant cytoplasm +MNXR103069 1 phosphate product cytoplasm +MNXR103069 1 diphosphate product cytoplasm +MNXR135003 1 H+ reactant extracellular +MNXR135003 1 triphosphate reactant extracellular +MNXR135003 1 triphosphate product cytoplasm +MNXR135003 1 H+ product cytoplasm +MNXR118731 1 cytidine 2'-phosphate reactant cytoplasm +MNXR118731 1 H2O reactant cytoplasm +MNXR118731 1 cytidine product cytoplasm +MNXR118731 1 phosphate product cytoplasm +MNXR135010 1 H+ reactant extracellular +MNXR135010 1 cytidine 2'-phosphate reactant extracellular +MNXR135010 1 cytidine 2'-phosphate product cytoplasm +MNXR135010 1 H+ product cytoplasm +MNXR117327 1 2',3'-cyclic UMP reactant cytoplasm +MNXR117327 1 H2O reactant cytoplasm +MNXR117327 1 uridine 2'-phosphate product cytoplasm +MNXR117327 1 H+ product cytoplasm +MNXR136674 1 H+ reactant extracellular +MNXR136674 1 2',3'-cyclic UMP reactant extracellular +MNXR136674 1 2',3'-cyclic UMP product cytoplasm +MNXR136674 1 H+ product cytoplasm +MNXR123155 1 3-sulfino-L-alanine reactant cytoplasm +MNXR123155 1 H2O reactant cytoplasm +MNXR123155 1 L-alanine product cytoplasm +MNXR123155 1 sulphite product cytoplasm +MNXR137086 1 H+ reactant extracellular +MNXR137086 1 3-sulfino-L-alanine reactant extracellular +MNXR137086 1 3-sulfino-L-alanine product cytoplasm +MNXR137086 1 H+ product cytoplasm +MNXR94935 1 3'-AMP reactant cytoplasm +MNXR94935 1 H2O reactant cytoplasm +MNXR94935 1 adenosine product cytoplasm +MNXR94935 1 phosphate product cytoplasm +MNXR94857 1 3'-AMP reactant extracellular +MNXR94857 1 3'-AMP product cytoplasm +MNXR130717 1 6-O-alpha-D-glucopyranosyl-D-fructofuranose reactant cytoplasm +MNXR130717 1 H2O reactant cytoplasm +MNXR130717 1 D-fructose product cytoplasm +MNXR130717 1 D-glucose product cytoplasm +MNXR102339 1 H+ reactant extracellular +MNXR102339 1 6-O-alpha-D-glucopyranosyl-D-fructofuranose reactant extracellular +MNXR102339 1 6-O-alpha-D-glucopyranosyl-D-fructofuranose product cytoplasm +MNXR102339 1 H+ product cytoplasm +MNXR103637 1 N-acetyl-L-cysteine reactant cytoplasm +MNXR103637 1 coenzyme A reactant cytoplasm +MNXR103637 1 H+ reactant cytoplasm +MNXR103637 1 acetyl-CoA product cytoplasm +MNXR103637 1 L-cysteine product cytoplasm +MNXR137052 1 H+ reactant extracellular +MNXR137052 1 N-acetyl-L-cysteine reactant extracellular +MNXR137052 1 N-acetyl-L-cysteine product cytoplasm +MNXR137052 1 H+ product cytoplasm +MNXR106345 1 tetrathionate reactant cytoplasm +MNXR106345 2 ferricytochrome c reactant mitochondrion +MNXR106345 2 thiosulfate product cytoplasm +MNXR106345 2 ferrocytochrome c product mitochondrion +MNXR104796 1 tetrathionate reactant extracellular +MNXR104796 1 tetrathionate product cytoplasm +L-methionine transport, vacuoluar 1 L-methionine reactant cytoplasm +L-methionine transport, vacuoluar 1 L-methionine product vacuole +MNXR99485 1 2-hydroxyethane-1-sulfonate reactant cytoplasm +MNXR99485 1 FMNH2 reactant cytoplasm +MNXR99485 1 oxygen reactant cytoplasm +MNXR99485 1 H+ product cytoplasm +MNXR99485 1 sulphite product cytoplasm +MNXR99485 1 H2O product cytoplasm +MNXR99485 1 FMN product cytoplasm +MNXR99485 1 glycolaldehyde product cytoplasm +MNXR137058 1 H+ reactant extracellular +MNXR137058 1 2-hydroxyethane-1-sulfonate reactant extracellular +MNXR137058 1 2-hydroxyethane-1-sulfonate product cytoplasm +MNXR137058 1 H+ product cytoplasm +MNXR95065 1 H+ reactant cytoplasm +MNXR95065 1 NADPH reactant cytoplasm +MNXR95065 1 5-dehydro-D-gluconate reactant cytoplasm +MNXR95065 1 D-gluconate product cytoplasm +MNXR95065 1 NADP(+) product cytoplasm +MNXR95066 1 H+ reactant extracellular +MNXR95066 1 5-dehydro-D-gluconate reactant extracellular +MNXR95066 1 5-dehydro-D-gluconate product cytoplasm +MNXR95066 1 H+ product cytoplasm +MNXR137135 1 Ala-Asp reactant extracellular +MNXR137135 1 H+ reactant extracellular +MNXR137135 1 H+ product cytoplasm +MNXR137135 1 Ala-Asp product cytoplasm +MNXR137135_cv 1 H+ reactant cytoplasm +MNXR137135_cv 1 Ala-Asp reactant cytoplasm +MNXR137135_cv 1 H+ product vacuole +MNXR137135_cv 1 Ala-Asp product vacuole +MNXR123344 1 Ala-Asp reactant vacuole +MNXR123344 1 H2O reactant vacuole +MNXR123344 1 L-alanine product vacuole +MNXR123344 1 L-aspartate product vacuole +MNXR96247 1 methyl alpha-D-glucopyranoside reactant cytoplasm +MNXR96247 1 H2O reactant cytoplasm +MNXR96247 1 D-glucose product cytoplasm +MNXR96247 1 methanol product cytoplasm +MNXR101464 1 methanol reactant cytoplasm +MNXR101464 1 methanol product extracellular +MNXR98748 1 methanol reactant extracellular +MNXR137048 1 H+ reactant extracellular +MNXR137048 1 methyl alpha-D-glucopyranoside reactant extracellular +MNXR137048 1 methyl alpha-D-glucopyranoside product cytoplasm +MNXR137048 1 H+ product cytoplasm +MNXR117326 1 2',3'-cyclic CMP reactant cytoplasm +MNXR117326 1 H2O reactant cytoplasm +MNXR117326 1 cytidine 2'-phosphate product cytoplasm +MNXR117326 1 H+ product cytoplasm +MNXR136673 1 H+ reactant extracellular +MNXR136673 1 2',3'-cyclic CMP reactant extracellular +MNXR136673 1 2',3'-cyclic CMP product cytoplasm +MNXR136673 1 H+ product cytoplasm +MNXR107830 1 D-tagatose reactant cytoplasm +MNXR107830 1 ATP reactant cytoplasm +MNXR107830 1 ADP product cytoplasm +MNXR107830 1 D-tagatofuranose 6-phosphate product cytoplasm +MNXR107830 1 H+ product cytoplasm +R11623 1 D-tagatofuranose 6-phosphate reactant cytoplasm +R11623 1 D-fructose 6-phosphate product cytoplasm +MNXR104707 1 D-tagatose reactant extracellular +MNXR104707 1 D-tagatose product cytoplasm +MNXR130716 1 turanose reactant extracellular +MNXR130716 1 H2O reactant extracellular +MNXR130716 1 D-fructose product extracellular +MNXR130716 1 D-glucose product extracellular +MNXR95136 1 acetoacetate reactant cytoplasm +MNXR95136 1 ATP reactant cytoplasm +MNXR95136 1 coenzyme A reactant cytoplasm +MNXR95136 1 AMP product cytoplasm +MNXR95136 1 diphosphate product cytoplasm +MNXR95136 1 acetoacetyl-CoA product cytoplasm +MNXR95208 1 acetoacetate reactant extracellular +MNXR95208 1 acetoacetate product cytoplasm +MNXR103709 1 N(alpha)-acetyl-L-methionine reactant cytoplasm +MNXR103709 1 H2O reactant cytoplasm +MNXR103709 1 acetate product cytoplasm +MNXR103709 1 L-methionine product cytoplasm +MNXR137089 1 H+ reactant extracellular +MNXR137089 1 N(alpha)-acetyl-L-methionine reactant extracellular +MNXR137089 1 N(alpha)-acetyl-L-methionine product cytoplasm +MNXR137089 1 H+ product cytoplasm +MNXR106549 1 3-oxalomalate(3-) reactant cytoplasm +MNXR106549 1 oxaloacetate product cytoplasm +MNXR106549 1 glyoxylate product cytoplasm +MNXR137067 1 H+ reactant extracellular +MNXR137067 1 3-oxalomalate(3-) reactant extracellular +MNXR137067 1 3-oxalomalate(3-) product cytoplasm +MNXR137067 1 H+ product cytoplasm +MNXR111236 1 L-cysteate reactant cytoplasm +MNXR111236 1 H2O reactant cytoplasm +MNXR111236 1 pyruvate product cytoplasm +MNXR111236 1 ammonium product cytoplasm +MNXR111236 1 sulphite product cytoplasm +MNXR124424 1 H+ reactant extracellular +MNXR124424 1 L-cysteate reactant extracellular +MNXR124424 1 L-cysteate product cytoplasm +MNXR124424 1 H+ product cytoplasm +MNXR101619 1 alpha-maltotriose reactant extracellular +MNXR101619 1 H2O reactant extracellular +MNXR101619 1 maltose product extracellular +MNXR101619 1 D-glucose product extracellular +MNXR94824 1 H+ reactant extracellular +MNXR94824 1 2-phospho-D-glyceric acid reactant extracellular +MNXR94824 1 2-phospho-D-glyceric acid product cytoplasm +MNXR94824 1 H+ product cytoplasm +MNXR94973 1 H+ reactant extracellular +MNXR94973 1 3-phosphonato-D-glycerate(3-) reactant extracellular +MNXR94973 1 3-phosphonato-D-glycerate(3-) product cytoplasm +MNXR94973 1 H+ product cytoplasm +Met-Ala transport via proton symport (extracellular to cytosol) 1 Met-Ala reactant extracellular +Met-Ala transport via proton symport (extracellular to cytosol) 1 H+ reactant extracellular +Met-Ala transport via proton symport (extracellular to cytosol) 1 H+ product cytoplasm +Met-Ala transport via proton symport (extracellular to cytosol) 1 Met-Ala product cytoplasm +Met-Ala transport via proton symport (cytosol to vacuole) 1 H+ reactant cytoplasm +Met-Ala transport via proton symport (cytosol to vacuole) 1 Met-Ala reactant cytoplasm +Met-Ala transport via proton symport (cytosol to vacuole) 1 H+ product vacuole +Met-Ala transport via proton symport (cytosol to vacuole) 1 Met-Ala product vacuole +MNXR99849 1 D-glucose 1-phosphate reactant extracellular +MNXR99849 1 D-glucose 1-phosphate product cytoplasm +MNXR96488 1 carbamoyl phosphate reactant extracellular +MNXR96488 1 carbamoyl phosphate product cytoplasm +MNXR103245 1 3-phospho-serine reactant extracellular +MNXR103245 1 H+ reactant extracellular +MNXR103245 1 H+ product cytoplasm +MNXR103245 1 3-phospho-serine product cytoplasm +MNXR100385 1 GMP reactant extracellular +MNXR100385 1 H+ reactant extracellular +MNXR100385 1 H+ product cytoplasm +MNXR100385 1 GMP product cytoplasm +MNXR101585 1 myo-inositol hexakisphosphate reactant extracellular +MNXR101585 1 myo-inositol hexakisphosphate product cytoplasm +MNXR98531 1 D-glucose 6-phosphate reactant extracellular +MNXR98531 1 D-glucose 6-phosphate product cytoplasm +MNXR105127 1 UMP reactant extracellular +MNXR105127 1 UMP product cytoplasm +MNXR102493 1 phosphoenolpyruvate reactant extracellular +MNXR102493 1 H+ reactant extracellular +MNXR102493 1 H+ product cytoplasm +MNXR102493 1 phosphoenolpyruvate product cytoplasm +MNXR101385 1 D-mannose 6-phosphate reactant extracellular +MNXR101385 1 D-mannose 6-phosphate product cytoplasm +MNXR135002 1 O-phosphoethanolamine reactant extracellular +MNXR135002 1 H+ reactant extracellular +MNXR135002 1 H+ product cytoplasm +MNXR135002 1 O-phosphoethanolamine product cytoplasm +MNXR95102 1 6-phospho-D-gluconate reactant extracellular +MNXR95102 1 H+ reactant extracellular +MNXR95102 1 H+ product cytoplasm +MNXR95102 1 6-phospho-D-gluconate product cytoplasm +MNXR101377 1 D-mannose 1-phosphate reactant extracellular +MNXR101377 1 H+ reactant extracellular +MNXR101377 1 H+ product cytoplasm +MNXR101377 1 D-mannose 1-phosphate product cytoplasm +MNXR136667 1 diphosphate reactant extracellular +MNXR136667 2 H+ reactant extracellular +MNXR136667 2 H+ product cytoplasm +MNXR136667 1 diphosphate product cytoplasm +MNXR96703 1 choline phosphate reactant extracellular +MNXR96703 1 choline phosphate product cytoplasm +MNXR104966 1 thiosulfate reactant extracellular +MNXR104966 1 thiosulfate product cytoplasm +MNXR95831 1 AMP reactant extracellular +MNXR95831 1 H+ reactant extracellular +MNXR95831 1 H+ product cytoplasm +MNXR95831 1 AMP product cytoplasm +MNXR94718 1 2',3'-cyclic AMP reactant extracellular +MNXR94718 1 2',3'-cyclic AMP product cytoplasm +MNXR135007 1 adenosine 2'-phosphate reactant extracellular +MNXR135007 1 H+ reactant extracellular +MNXR135007 1 H+ product cytoplasm +MNXR135007 1 adenosine 2'-phosphate product cytoplasm +MNXR96805 1 CMP reactant extracellular +MNXR96805 1 H+ reactant extracellular +MNXR96805 1 H+ product cytoplasm +MNXR96805 1 CMP product cytoplasm +MNXR100035 1 D-Glucosamine reactant extracellular +MNXR100035 1 D-Glucosamine product cytoplasm +2-deoxy-D-ribose transport 1 2-deoxy-D-ribose reactant extracellular +2-deoxy-D-ribose transport 1 2-deoxy-D-ribose product cytoplasm +MNXR96737 1 L-citrulline reactant extracellular +MNXR96737 1 H+ reactant extracellular +MNXR96737 1 H+ product cytoplasm +MNXR96737 1 L-citrulline product cytoplasm +MNXR97367 1 glycerone reactant extracellular +MNXR97367 1 glycerone product cytoplasm +Ala-Leu transport via proton symport (extracellular to cytosol) 1 Ala-Leu reactant extracellular +Ala-Leu transport via proton symport (extracellular to cytosol) 1 H+ reactant extracellular +Ala-Leu transport via proton symport (extracellular to cytosol) 1 H+ product cytoplasm +Ala-Leu transport via proton symport (extracellular to cytosol) 1 Ala-Leu product cytoplasm +Ala-Leu transport via proton symport (cytosol to vacuole) 1 H+ reactant cytoplasm +Ala-Leu transport via proton symport (cytosol to vacuole) 1 Ala-Leu reactant cytoplasm +Ala-Leu transport via proton symport (cytosol to vacuole) 1 H+ product vacuole +Ala-Leu transport via proton symport (cytosol to vacuole) 1 Ala-Leu product vacuole +MNXR137133 1 Ala-Gly reactant extracellular +MNXR137133 1 H+ reactant extracellular +MNXR137133 1 H+ product cytoplasm +MNXR137133 1 Ala-Gly product cytoplasm +MNXR137133_cv 1 H+ reactant cytoplasm +MNXR137133_cv 1 Ala-Gly reactant cytoplasm +MNXR137133_cv 1 H+ product vacuole +MNXR137133_cv 1 Ala-Gly product vacuole +N-acetyl-L-glutamate transport 1 N-acetyl-L-glutamate reactant extracellular +N-acetyl-L-glutamate transport 1 N-acetyl-L-glutamate product cytoplasm +N-acetyl-L-glutamate transport, mitochondrion 1 N-acetyl-L-glutamate reactant cytoplasm +N-acetyl-L-glutamate transport, mitochondrion 1 N-acetyl-L-glutamate product mitochondrion +MNXR137094 1 lipoamide reactant extracellular +MNXR137094 1 H+ reactant extracellular +MNXR137094 1 H+ product cytoplasm +MNXR137094 1 lipoamide product cytoplasm +MNXR101483 1 L-Methionine S-oxide reactant extracellular +MNXR101483 1 L-Methionine S-oxide product cytoplasm +Hydrogen sulfide oxidation 1 hydrogen sulfide reactant cytoplasm +Hydrogen sulfide oxidation 2 oxygen reactant cytoplasm +Hydrogen sulfide oxidation 1 H+ product cytoplasm +Hydrogen sulfide oxidation 1 sulphate product cytoplasm +MNXR95704 1 H+ reactant cytoplasm +MNXR95704 1 L-alanine reactant cytoplasm +MNXR95704 1 L-alanine product vacuole +MNXR95704 1 H+ product vacuole +MNXR100368 1 H+ reactant cytoplasm +MNXR100368 1 L-glycine reactant cytoplasm +MNXR100368 1 L-glycine product vacuole +MNXR100368 1 H+ product vacuole +MNXR104382 1 O-succinyl-L-homoserine reactant cytoplasm +MNXR104382 1 hydrogen sulfide reactant cytoplasm +MNXR104382 1 L-homocysteine product cytoplasm +MNXR104382 1 succinate product cytoplasm +MNXR94843 1 oxygen reactant cytoplasm +MNXR94843 1 3-(4-hydroxyphenyl)pyruvate reactant cytoplasm +MNXR94843 1 homogentisate product cytoplasm +MNXR94843 1 carbon dioxide product cytoplasm +MNXR100628 1 homogentisate reactant cytoplasm +MNXR100628 1 oxygen reactant cytoplasm +MNXR100628 1 4-maleylacetoacetate product cytoplasm +MNXR100628 1 H+ product cytoplasm +MNXR101325 1 4-maleylacetoacetate reactant cytoplasm +MNXR101325 1 4-fumarylacetoacetate product cytoplasm +MNXR99706 1 4-fumarylacetoacetate reactant cytoplasm +MNXR99706 1 H2O reactant cytoplasm +MNXR99706 1 fumarate product cytoplasm +MNXR99706 1 acetoacetate product cytoplasm +MNXR99706 1 H+ product cytoplasm +MNXR95187 1 L-arabinitol reactant cytoplasm +MNXR95187 1 NAD reactant cytoplasm +MNXR95187 1 H+ product cytoplasm +MNXR95187 1 NADH product cytoplasm +MNXR95187 1 L-xylulose product cytoplasm +MNXR105265 1 L-xylulose reactant cytoplasm +MNXR105265 1 NADPH reactant cytoplasm +MNXR105265 1 H+ reactant cytoplasm +MNXR105265 1 xylitol product cytoplasm +MNXR105265 1 NADP(+) product cytoplasm +arabinose reductase (D-arabinose) 1 D-arabinose reactant cytoplasm +arabinose reductase (D-arabinose) 1 NADPH reactant cytoplasm +arabinose reductase (D-arabinose) 1 H+ reactant cytoplasm +arabinose reductase (D-arabinose) 1 D-arabinitol product cytoplasm +arabinose reductase (D-arabinose) 1 NADP(+) product cytoplasm +MNXR95188 1 D-arabinitol reactant cytoplasm +MNXR95188 1 NAD reactant cytoplasm +MNXR95188 1 H+ product cytoplasm +MNXR95188 1 NADH product cytoplasm +MNXR95188 1 D-xylulose product cytoplasm +MNXR118733 1 adenosine 2'-phosphate reactant cytoplasm +MNXR118733 1 H2O reactant cytoplasm +MNXR118733 1 adenosine product cytoplasm +MNXR118733 1 phosphate product cytoplasm diff --git a/ComplementaryData/modelCuration/Biolog_newRxnMetAnnotation.tsv b/ComplementaryData/modelCuration/Biolog_newRxnMetAnnotation.tsv index 12926410..0e1c1f48 100644 --- a/ComplementaryData/modelCuration/Biolog_newRxnMetAnnotation.tsv +++ b/ComplementaryData/modelCuration/Biolog_newRxnMetAnnotation.tsv @@ -1,152 +1,152 @@ -NewMetName Charged formula Charge compartment KEGG ID CHEBI ID Remark -Ala-Gln [extracellular] C8H15N3O4 0 extracellular CHEBI:73788 MNXM40495 -Ala-Gln [cytoplasm] C8H15N3O4 0 cytoplasm CHEBI:73788 MNXM40495 -Ala-Gln [vacuole] C8H15N3O4 0 vacuole CHEBI:73788 MNXM40495 -Ala-Glu [extracellular] C8H13N2O5 -1 extracellular C20958 CHEBI:61396 MNXM4026 -Ala-Glu [cytoplasm] C8H13N2O5 -1 cytoplasm C20958 CHEBI:61396 MNXM4026 -Ala-Glu [vacuole] C8H13N2O5 -1 vacuole C20958 CHEBI:61396 MNXM4026 -Ala-Thr [extracellular] C7H14N2O4 0 extracellular CHEBI:73762 MNXM40497 -Ala-Thr [cytoplasm] C7H14N2O4 0 cytoplasm CHEBI:73762 MNXM40497 -Ala-Thr [vacuole] C7H14N2O4 0 vacuole CHEBI:73762 MNXM40497 -L-threonine [vacuole] C4H9NO3 0 vacuole C00188 CHEBI:16857 MNXM142 -thymidine 3'-monophosphate [cytoplasm] C10H13N2O8P -2 cytoplasm CHEBI:77843 MNXM87165 -thymidine 3'-monophosphate [extracellular] C10H13N2O8P -2 extracellular CHEBI:77843 MNXM87165 -thymidine 5'-monophosphate [cytoplasm] C10H13N2O8P -2 cytoplasm CHEBI:15245 MNXM87167 -thymidine 5'-monophosphate [extracellular] C10H13N2O8P -2 extracellular CHEBI:15245 MNXM87167 -glycerol 1-phosphate [cytoplasm] C3H7O6P -2 cytoplasm C03189 CHEBI:231935 MNXM682 -glycerol 1-phosphate [extracellular] C3H7O6P -2 extracellular C03189 CHEBI:231935 MNXM682 -Ala-His [extracellular] C9H14N4O3 0 extracellular CHEBI:73771 MNXM40496 -Ala-His [cytoplasm] C9H14N4O3 0 cytoplasm CHEBI:73771 MNXM40496 -Ala-His [vacuole] C9H14N4O3 0 vacuole CHEBI:73771 MNXM40496 -Gly-Asn [extracellular] C6H11N3O4 0 extracellular CHEBI:73888 MNXM55268 -Gly-Asn [cytoplasm] C6H11N3O4 0 cytoplasm CHEBI:73888 MNXM55268 -Gly-Asn [vacuole] C6H11N3O4 0 vacuole CHEBI:73888 MNXM55268 -Gly-Gln [extracellular] C7H13N3O4 0 extracellular CHEBI:73898 MNXM55276 -Gly-Gln [cytoplasm] C7H13N3O4 0 cytoplasm CHEBI:73898 MNXM55276 -Gly-Gln [vacuole] C7H13N3O4 0 vacuole CHEBI:73898 MNXM55276 -Gly-Glu [extracellular] C7H11N2O5 -1 extracellular CHEBI:73784 MNXM55454 -Gly-Glu [cytoplasm] C7H11N2O5 -1 cytoplasm CHEBI:73784 MNXM55454 -Gly-Glu [vacuole] C7H11N2O5 -1 vacuole CHEBI:73784 MNXM55454 -glycerol 2-phosphate(2-) [cytoplasm] C3H7O6P -2 cytoplasm C02979 CHEBI:58083 MNXM2527 -glycerol 2-phosphate(2-) [extracellular] C3H7O6P -2 extracellular C02979 CHEBI:58083 MNXM2527 -O-phospho-L-threonine [cytoplasm] C4H8NO6P -2 cytoplasm C12147 CHEBI:58675 MNXM1492 -O-phospho-L-threonine [extracellular] C4H8NO6P -2 extracellular C12147 CHEBI:58675 MNXM1492 -guanosine 2'-monophosphate [cytoplasm] C10H12N5O8P -2 cytoplasm CHEBI:74604 MNXM18285 -guanosine 2'-monophosphate [extracellular] C10H12N5O8P -2 extracellular CHEBI:74604 MNXM18285 -3'-GMP [cytoplasm] C10H12N5O8P -2 cytoplasm C06193 CHEBI:60732 MNXM2183 -3'-GMP [extracellular] C10H12N5O8P -2 extracellular C06193 CHEBI:60732 MNXM2183 -2-phosphoglycolate [extracellular] C2H2O6P -3 extracellular C00988 CHEBI:58033 MNXM2074 -2-phosphoglycolate [cytoplasm] C2H2O6P -3 cytoplasm C00988 CHEBI:58033 MNXM2074 -cysteamine S-phosphate [cytoplasm] C2H7NO3PS -1 cytoplasm CHEBI:74631 MNXM48297 -cysteamine [cytoplasm] C2H8NS 1 cytoplasm C01678 CHEBI:58029 MNXM1226 -cysteamine [extracellular] C2H8NS 1 extracellular C01678 CHEBI:58029 MNXM1226 -cysteamine S-phosphate [extracellular] C2H7NO3PS -1 extracellular CHEBI:74631 MNXM48297 -hypotaurine [cytoplasm] C2H7NO2S 0 cytoplasm C00519 CHEBI:16668 MNXM726 -O-phosphonatooxy-D-serine(2-) [cytoplasm] C3H6NO6P -2 cytoplasm C02532 CHEBI:58680 MNXM4752 -O-phosphonatooxy-D-serine(2-) [extracellular] C3H6NO6P -2 extracellular C02532 CHEBI:58680 MNXM4752 -2-aminobutanoate [cytoplasm] C4H9NO2 0 cytoplasm CHEBI:35621 MNXM15850 -2-aminobutanoate [extracellular] C4H9NO2 0 extracellular CHEBI:35621 MNXM15850 -uridine 2'-phosphate [cytoplasm] C9H11N2O9P -2 cytoplasm C03031 CHEBI:77802 MNXM13238 -uridine 2'-phosphate [extracellular] C9H11N2O9P -2 extracellular C03031 CHEBI:77802 MNXM13238 -3'-UMP [cytoplasm] C9H11N2O9P -2 cytoplasm C01368 CHEBI:60784 MNXM2184 -3'-UMP [extracellular] C9H11N2O9P -2 extracellular C01368 CHEBI:60784 MNXM2184 -Gly-Met [extracellular] C7H14N2O3S 0 extracellular CHEBI:74393 MNXM55287 -Gly-Met [cytoplasm] C7H14N2O3S 0 cytoplasm CHEBI:74393 MNXM55287 -Gly-Met [vacuole] C7H14N2O3S 0 vacuole CHEBI:74393 MNXM55287 -N-phosphocreatine [cytoplasm] C4H8N3O5P -2 cytoplasm CHEBI:58092 MNXM819 -creatinine [cytoplasm] C4H7N3O 0 cytoplasm C00791 CHEBI:16737 MNXM1470 -N-phosphocreatine [extracellular] C4H8N3O5P -2 extracellular CHEBI:58092 MNXM819 -creatinine [extracellular] C4H7N3O 0 extracellular C00791 CHEBI:16737 MNXM1470 -N(omega)-phospho-L-arginine [cytoplasm] C6H14N4O5P -1 cytoplasm C05945 CHEBI:58477 MNXM3663 -N(omega)-phospho-L-arginine [extracellular] C6H14N4O5P -1 extracellular C05945 CHEBI:58477 MNXM3663 -2',3'-cyclic GMP [cytoplasm] C10H11N5O7P -1 cytoplasm C06194 CHEBI:60837 MNXM3149 -2',3'-cyclic GMP [extracellular] C10H11N5O7P -1 extracellular C06194 CHEBI:60837 MNXM3149 -O(4)-phospho-L-tyrosine [cytoplasm] C9H10NO6P -2 cytoplasm C06501 CHEBI:62338 MNXM3323 -O(4)-phospho-L-tyrosine [extracellular] C9H10NO6P -2 extracellular C06501 CHEBI:62338 MNXM3323 -triphosphate [cytoplasm] O10P3 -5 cytoplasm C00536 CHEBI:18036 MNXM332 -triphosphate [extracellular] O10P3 -5 extracellular C00536 CHEBI:18036 MNXM332 -cytidine 2'-phosphate [cytoplasm] C9H12N3O8P -2 cytoplasm C03104 CHEBI:77766 MNXM11237 -cytidine 2'-phosphate [extracellular] C9H12N3O8P -2 extracellular C03104 CHEBI:77766 MNXM11237 -2',3'-cyclic UMP [cytoplasm] C9H10N2O8P -1 cytoplasm C02355 CHEBI:60873 MNXM3150 -2',3'-cyclic UMP [extracellular] C9H10N2O8P -1 extracellular C02355 CHEBI:60873 MNXM3150 -3-sulfino-L-alanine [cytoplasm] C3H6NO4S -1 cytoplasm C00606 CHEBI:61085 MNXM498 -3-sulfino-L-alanine [extracellular] C3H6NO4S -1 extracellular C00606 CHEBI:61085 MNXM498 -3'-AMP [cytoplasm] C10H12N5O7P -2 cytoplasm C01367 CHEBI:60880 MNXM1985 -3'-AMP [extracellular] C10H12N5O7P -2 extracellular C01367 CHEBI:60880 MNXM1985 -6-O-alpha-D-glucopyranosyl-D-fructofuranose [cytoplasm] C12H22O11 0 cytoplasm C01742 CHEBI:18394 MNXM3518 -6-O-alpha-D-glucopyranosyl-D-fructofuranose [extracellular] C12H22O11 0 extracellular C01742 CHEBI:18394 MNXM3518 -N-acetyl-L-cysteine [cytoplasm] C5H8NO3S -1 cytoplasm C06809 CHEBI:78236 MNXM98606 -N-acetyl-L-cysteine [extracellular] C5H8NO3S -1 extracellular C06809 CHEBI:78236 MNXM98606 -tetrathionate [cytoplasm] O6S4 -2 cytoplasm C02084 CHEBI:15226 MNXM1781 -thiosulfate [cytoplasm] HO3S2 -1 cytoplasm C00320 CHEBI:33542 MNXM323 -tetrathionate [extracellular] O6S4 -2 extracellular C02084 CHEBI:15226 MNXM1781 -glycyl-L-methionine [extracellular] C7H14N2O3S 0 extracellular CHEBI:74393 MNXM55287 -glycyl-L-methionine [cytoplasm] C7H14N2O3S 0 cytoplasm CHEBI:74393 MNXM55287 -glycyl-L-methionine [vacuole] C7H14N2O3S 0 vacuole CHEBI:74393 MNXM55287 -2-hydroxyethane-1-sulfonate [cytoplasm] C2H5O4S -1 cytoplasm C05123 CHEBI:61904 MNXM1630 -2-hydroxyethane-1-sulfonate [extracellular] C2H5O4S -1 extracellular C05123 CHEBI:61904 MNXM1630 -5-dehydro-D-gluconate [cytoplasm] C6H9O7 -1 cytoplasm C01062 CHEBI:58143 MNXM963 -5-dehydro-D-gluconate [extracellular] C6H9O7 -1 extracellular C01062 CHEBI:58143 MNXM963 -Ala-Asp [extracellular] C7H11N2O5 -1 extracellular CHEBI:74363 MNXM40494 -Ala-Asp [cytoplasm] C7H11N2O5 -1 cytoplasm CHEBI:74363 MNXM40494 -Ala-Asp [vacuole] C7H11N2O5 -1 vacuole CHEBI:74363 MNXM40494 -methyl alpha-D-glucopyranoside [cytoplasm] C7H14O6 0 cytoplasm CHEBI:320061 MNXM61741 -methanol [cytoplasm] CH4O 0 cytoplasm C00132 CHEBI:17790 MNXM157 -methanol [extracellular] CH4O 0 extracellular C00132 CHEBI:17790 MNXM157 -methyl alpha-D-glucopyranoside [extracellular] C7H14O6 0 extracellular CHEBI:320061 MNXM61741 -2',3'-cyclic CMP [cytoplasm] C9H11N3O7P -1 cytoplasm C02354 CHEBI:60877 MNXM3148 -2',3'-cyclic CMP [extracellular] C9H11N3O7P -1 extracellular C02354 CHEBI:60877 MNXM3148 -D-tagatose [cytoplasm] C6H12O6 0 cytoplasm C00795 CHEBI:4249 MNXM92401 -D-tagatofuranose 6-phosphate [cytoplasm] C6H11O9P -2 cytoplasm C01097 CHEBI:58695 MNXM795 -D-tagatose [extracellular] C6H12O6 0 extracellular C00795 CHEBI:4249 MNXM92401 -turanose [extracellular] C12H22O11 0 extracellular C19636 CHEBI:32528 MNXM161984 -acetoacetate [cytoplasm] C4H5O3 -1 cytoplasm C00164 CHEBI:13705 MNXM154 -acetoacetate [extracellular] C4H5O3 -1 extracellular C00164 CHEBI:13705 MNXM154 -N(alpha)-acetyl-L-methionine [cytoplasm] C7H12NO3S -1 cytoplasm C02712 CHEBI:132957 MNXM7576 -N(alpha)-acetyl-L-methionine [extracellular] C7H12NO3S -1 extracellular C02712 CHEBI:132957 MNXM7576 -3-oxalomalate(3-) [cytoplasm] C6H3O8 -3 cytoplasm C01990 CHEBI:15593 MNXM3850 -3-oxalomalate(3-) [extracellular] C6H3O8 -3 extracellular C01990 CHEBI:15593 MNXM3850 -L-cysteate [cytoplasm] C3H6NO5S -1 cytoplasm C00506 CHEBI:58090 MNXM713 -L-cysteate [extracellular] C3H6NO5S -1 extracellular C00506 CHEBI:58090 MNXM713 -alpha-maltotriose [extracellular] C18H32O16 0 extracellular C01835 CHEBI:61993 MNXM468 -2-phospho-D-glyceric acid [extracellular] C3H4O7P -3 extracellular C00631 CHEBI:58289 MNXM275 -3-phosphonato-D-glycerate(3-) [extracellular] C3H4O7P -3 extracellular C00197 CHEBI:58272 MNXM126 -Met-Ala [extracellular] C8H16N2O3S 0 extracellular CHEBI:73610 MNXM61647 -Met-Ala [cytoplasm] C8H16N2O3S 0 cytoplasm CHEBI:73610 MNXM61647 -D-glucose 1-phosphate [extracellular] C6H11O9P -2 extracellular C00103 CHEBI:57629 MNXM89588 -carbamoyl phosphate [extracellular] CH2NO5P -2 extracellular C00169 CHEBI:58228 MNXM138 -3-phospho-serine [extracellular] C3H6NO6P -2 extracellular C01005 CHEBI:57524 MNXM379 -GMP [extracellular] C10H12N5O8P -2 extracellular C00144 CHEBI:58115 MNXM113 -myo-inositol hexakisphosphate [extracellular] C6H6O24P6 -12 extracellular C01204 CHEBI:58130 MNXM491 -D-glucose 6-phosphate [extracellular] C6H11O9P -2 extracellular C00092 CHEBI:61548 MNXM160 -UMP [extracellular] C9H11N2O9P -2 extracellular C00105 CHEBI:57865 MNXM80 -phosphoenolpyruvate [extracellular] C3H2O6P -3 extracellular C00074 CHEBI:58702 MNXM73 -D-mannose 6-phosphate [extracellular] C6H11O9P -2 extracellular C00275 CHEBI:58735 MNXM427 -O-phosphoethanolamine [extracellular] C2H7NO4P -1 extracellular C00346 CHEBI:58190 MNXM187 -6-phospho-D-gluconate [extracellular] C6H10O10P -3 extracellular C00345 CHEBI:58759 MNXM325 -D-mannose 1-phosphate [extracellular] C6H11O9P -2 extracellular C00636 CHEBI:58409 MNXM721 -diphosphate [extracellular] HO7P2 -3 extracellular C00013 CHEBI:33019 MNXM11 -choline phosphate [extracellular] C5H13NO4P -1 extracellular C00588 CHEBI:295975 MNXM229 -thiosulfate [extracellular] HO3S2 -1 extracellular C00320 CHEBI:33542 MNXM323 -AMP [extracellular] C10H12N5O7P -2 extracellular C00020 CHEBI:456215 MNXM14 -2',3'-cyclic AMP [extracellular] C10H11N5O6P -1 extracellular C02353 CHEBI:60879 MNXM2598 -adenosine 2'-phosphate [extracellular] C10H12N5O7P -2 extracellular C00946 CHEBI:77740 MNXM7028 -CMP [extracellular] C9H12N3O8P -2 extracellular C00055 CHEBI:60377 MNXM31 -D-Glucosamine [extracellular] C6H14NO5 1 extracellular C00329 CHEBI:58723 MNXM533 -2-deoxy-D-ribose [extracellular] C5H10O4 0 extracellular C08347 CHEBI:28816 MNXM2474 -L-citrulline [extracellular] C6H13N3O3 0 extracellular C00327 CHEBI:16349 MNXM211 -glycerone [extracellular] C3H6O3 0 extracellular C00184 CHEBI:16016 MNXM460 -Ala-Leu [extracellular] C9H18N2O3 0 extracellular CHEBI:73770 MNXM15786 -Ala-Leu [cytoplasm] C9H18N2O3 0 cytoplasm CHEBI:73770 MNXM15786 -Ala-Gly [extracellular] C5H10N2O3 0 extracellular CHEBI:73757 MNXM15783 -Ala-Gly [cytoplasm] C5H10N2O3 0 cytoplasm CHEBI:73757 MNXM15783 -N-acetyl-L-glutamate [extracellular] C7H9NO5 -2 extracellular C00624 CHEBI:44337 MNXM730 -N-acetyl-L-glutamate [cytoplasm] C7H9NO5 -2 cytoplasm C00624 CHEBI:44337 MNXM730 -lipoamide [extracellular] C8H15NOS2 0 extracellular C00248 CHEBI:17460 MNXM1024 -lipoamide [cytoplasm] C8H15NOS2 0 cytoplasm C00248 CHEBI:17460 MNXM1024 -L-Methionine S-oxide [extracellular] C5H11NO3S 0 extracellular C02989 CHEBI:17016 MNXM2246 -homogentisate [cytoplasm] C8H7O4 -1 cytoplasm C00544 CHEBI:16169 MNXM345 -4-maleylacetoacetate [cytoplasm] C8H6O6 -2 cytoplasm C01036 CHEBI:17105 MNXM691 -4-fumarylacetoacetate [cytoplasm] C8H6O6 -2 cytoplasm C01061 CHEBI:18034 MNXM708 -L-xylulose [cytoplasm] C5H10O5 0 cytoplasm C00310 CHEBI:17140 MNXM597 -D-arabinitol [cytoplasm] C5H12O5 0 cytoplasm C01904 CHEBI:18333 MNXM1018 +NewMetName Charged formula Charge compartment KEGG ID CHEBI ID Remark +Ala-Gln [extracellular] C8H15N3O4 0 extracellular CHEBI:73788 MNXM40495 +Ala-Gln [cytoplasm] C8H15N3O4 0 cytoplasm CHEBI:73788 MNXM40495 +Ala-Gln [vacuole] C8H15N3O4 0 vacuole CHEBI:73788 MNXM40495 +Ala-Glu [extracellular] C8H13N2O5 -1 extracellular C20958 CHEBI:61396 MNXM4026 +Ala-Glu [cytoplasm] C8H13N2O5 -1 cytoplasm C20958 CHEBI:61396 MNXM4026 +Ala-Glu [vacuole] C8H13N2O5 -1 vacuole C20958 CHEBI:61396 MNXM4026 +Ala-Thr [extracellular] C7H14N2O4 0 extracellular CHEBI:73762 MNXM40497 +Ala-Thr [cytoplasm] C7H14N2O4 0 cytoplasm CHEBI:73762 MNXM40497 +Ala-Thr [vacuole] C7H14N2O4 0 vacuole CHEBI:73762 MNXM40497 +L-threonine [vacuole] C4H9NO3 0 vacuole C00188 CHEBI:16857 MNXM142 +thymidine 3'-monophosphate [cytoplasm] C10H13N2O8P -2 cytoplasm CHEBI:77843 MNXM87165 +thymidine 3'-monophosphate [extracellular] C10H13N2O8P -2 extracellular CHEBI:77843 MNXM87165 +thymidine 5'-monophosphate [cytoplasm] C10H13N2O8P -2 cytoplasm CHEBI:15245 MNXM87167 +thymidine 5'-monophosphate [extracellular] C10H13N2O8P -2 extracellular CHEBI:15245 MNXM87167 +glycerol 1-phosphate [cytoplasm] C3H7O6P -2 cytoplasm C03189 CHEBI:231935 MNXM682 +glycerol 1-phosphate [extracellular] C3H7O6P -2 extracellular C03189 CHEBI:231935 MNXM682 +Ala-His [extracellular] C9H14N4O3 0 extracellular CHEBI:73771 MNXM40496 +Ala-His [cytoplasm] C9H14N4O3 0 cytoplasm CHEBI:73771 MNXM40496 +Ala-His [vacuole] C9H14N4O3 0 vacuole CHEBI:73771 MNXM40496 +Gly-Asn [extracellular] C6H11N3O4 0 extracellular CHEBI:73888 MNXM55268 +Gly-Asn [cytoplasm] C6H11N3O4 0 cytoplasm CHEBI:73888 MNXM55268 +Gly-Asn [vacuole] C6H11N3O4 0 vacuole CHEBI:73888 MNXM55268 +Gly-Gln [extracellular] C7H13N3O4 0 extracellular CHEBI:73898 MNXM55276 +Gly-Gln [cytoplasm] C7H13N3O4 0 cytoplasm CHEBI:73898 MNXM55276 +Gly-Gln [vacuole] C7H13N3O4 0 vacuole CHEBI:73898 MNXM55276 +Gly-Glu [extracellular] C7H11N2O5 -1 extracellular CHEBI:73784 MNXM55454 +Gly-Glu [cytoplasm] C7H11N2O5 -1 cytoplasm CHEBI:73784 MNXM55454 +Gly-Glu [vacuole] C7H11N2O5 -1 vacuole CHEBI:73784 MNXM55454 +glycerol 2-phosphate(2-) [cytoplasm] C3H7O6P -2 cytoplasm C02979 CHEBI:58083 MNXM2527 +glycerol 2-phosphate(2-) [extracellular] C3H7O6P -2 extracellular C02979 CHEBI:58083 MNXM2527 +O-phospho-L-threonine [cytoplasm] C4H8NO6P -2 cytoplasm C12147 CHEBI:58675 MNXM1492 +O-phospho-L-threonine [extracellular] C4H8NO6P -2 extracellular C12147 CHEBI:58675 MNXM1492 +guanosine 2'-monophosphate [cytoplasm] C10H12N5O8P -2 cytoplasm CHEBI:74604 MNXM18285 +guanosine 2'-monophosphate [extracellular] C10H12N5O8P -2 extracellular CHEBI:74604 MNXM18285 +3'-GMP [cytoplasm] C10H12N5O8P -2 cytoplasm C06193 CHEBI:60732 MNXM2183 +3'-GMP [extracellular] C10H12N5O8P -2 extracellular C06193 CHEBI:60732 MNXM2183 +2-phosphoglycolate [extracellular] C2H2O6P -3 extracellular C00988 CHEBI:58033 MNXM2074 +2-phosphoglycolate [cytoplasm] C2H2O6P -3 cytoplasm C00988 CHEBI:58033 MNXM2074 +cysteamine S-phosphate [cytoplasm] C2H7NO3PS -1 cytoplasm CHEBI:74631 MNXM48297 +cysteamine [cytoplasm] C2H8NS 1 cytoplasm C01678 CHEBI:58029 MNXM1226 +cysteamine [extracellular] C2H8NS 1 extracellular C01678 CHEBI:58029 MNXM1226 +cysteamine S-phosphate [extracellular] C2H7NO3PS -1 extracellular CHEBI:74631 MNXM48297 +hypotaurine [cytoplasm] C2H7NO2S 0 cytoplasm C00519 CHEBI:16668 MNXM726 +O-phosphonatooxy-D-serine(2-) [cytoplasm] C3H6NO6P -2 cytoplasm C02532 CHEBI:58680 MNXM4752 +O-phosphonatooxy-D-serine(2-) [extracellular] C3H6NO6P -2 extracellular C02532 CHEBI:58680 MNXM4752 +2-aminobutanoate [cytoplasm] C4H9NO2 0 cytoplasm CHEBI:35621 MNXM15850 +2-aminobutanoate [extracellular] C4H9NO2 0 extracellular CHEBI:35621 MNXM15850 +uridine 2'-phosphate [cytoplasm] C9H11N2O9P -2 cytoplasm C03031 CHEBI:77802 MNXM13238 +uridine 2'-phosphate [extracellular] C9H11N2O9P -2 extracellular C03031 CHEBI:77802 MNXM13238 +3'-UMP [cytoplasm] C9H11N2O9P -2 cytoplasm C01368 CHEBI:60784 MNXM2184 +3'-UMP [extracellular] C9H11N2O9P -2 extracellular C01368 CHEBI:60784 MNXM2184 +Gly-Met [extracellular] C7H14N2O3S 0 extracellular CHEBI:74393 MNXM55287 +Gly-Met [cytoplasm] C7H14N2O3S 0 cytoplasm CHEBI:74393 MNXM55287 +Gly-Met [vacuole] C7H14N2O3S 0 vacuole CHEBI:74393 MNXM55287 +N-phosphocreatine [cytoplasm] C4H8N3O5P -2 cytoplasm CHEBI:58092 MNXM819 +creatinine [cytoplasm] C4H7N3O 0 cytoplasm C00791 CHEBI:16737 MNXM1470 +N-phosphocreatine [extracellular] C4H8N3O5P -2 extracellular CHEBI:58092 MNXM819 +creatinine [extracellular] C4H7N3O 0 extracellular C00791 CHEBI:16737 MNXM1470 +N(omega)-phospho-L-arginine [cytoplasm] C6H14N4O5P -1 cytoplasm C05945 CHEBI:58477 MNXM3663 +N(omega)-phospho-L-arginine [extracellular] C6H14N4O5P -1 extracellular C05945 CHEBI:58477 MNXM3663 +2',3'-cyclic GMP [cytoplasm] C10H11N5O7P -1 cytoplasm C06194 CHEBI:60837 MNXM3149 +2',3'-cyclic GMP [extracellular] C10H11N5O7P -1 extracellular C06194 CHEBI:60837 MNXM3149 +O(4)-phospho-L-tyrosine [cytoplasm] C9H10NO6P -2 cytoplasm C06501 CHEBI:62338 MNXM3323 +O(4)-phospho-L-tyrosine [extracellular] C9H10NO6P -2 extracellular C06501 CHEBI:62338 MNXM3323 +triphosphate [cytoplasm] O10P3 -5 cytoplasm C00536 CHEBI:18036 MNXM332 +triphosphate [extracellular] O10P3 -5 extracellular C00536 CHEBI:18036 MNXM332 +cytidine 2'-phosphate [cytoplasm] C9H12N3O8P -2 cytoplasm C03104 CHEBI:77766 MNXM11237 +cytidine 2'-phosphate [extracellular] C9H12N3O8P -2 extracellular C03104 CHEBI:77766 MNXM11237 +2',3'-cyclic UMP [cytoplasm] C9H10N2O8P -1 cytoplasm C02355 CHEBI:60873 MNXM3150 +2',3'-cyclic UMP [extracellular] C9H10N2O8P -1 extracellular C02355 CHEBI:60873 MNXM3150 +3-sulfino-L-alanine [cytoplasm] C3H6NO4S -1 cytoplasm C00606 CHEBI:61085 MNXM498 +3-sulfino-L-alanine [extracellular] C3H6NO4S -1 extracellular C00606 CHEBI:61085 MNXM498 +3'-AMP [cytoplasm] C10H12N5O7P -2 cytoplasm C01367 CHEBI:60880 MNXM1985 +3'-AMP [extracellular] C10H12N5O7P -2 extracellular C01367 CHEBI:60880 MNXM1985 +6-O-alpha-D-glucopyranosyl-D-fructofuranose [cytoplasm] C12H22O11 0 cytoplasm C01742 CHEBI:18394 MNXM3518 +6-O-alpha-D-glucopyranosyl-D-fructofuranose [extracellular] C12H22O11 0 extracellular C01742 CHEBI:18394 MNXM3518 +N-acetyl-L-cysteine [cytoplasm] C5H8NO3S -1 cytoplasm C06809 CHEBI:78236 MNXM98606 +N-acetyl-L-cysteine [extracellular] C5H8NO3S -1 extracellular C06809 CHEBI:78236 MNXM98606 +tetrathionate [cytoplasm] O6S4 -2 cytoplasm C02084 CHEBI:15226 MNXM1781 +thiosulfate [cytoplasm] HO3S2 -1 cytoplasm C00320 CHEBI:33542 MNXM323 +tetrathionate [extracellular] O6S4 -2 extracellular C02084 CHEBI:15226 MNXM1781 +glycyl-L-methionine [extracellular] C7H14N2O3S 0 extracellular CHEBI:74393 MNXM55287 +glycyl-L-methionine [cytoplasm] C7H14N2O3S 0 cytoplasm CHEBI:74393 MNXM55287 +glycyl-L-methionine [vacuole] C7H14N2O3S 0 vacuole CHEBI:74393 MNXM55287 +2-hydroxyethane-1-sulfonate [cytoplasm] C2H5O4S -1 cytoplasm C05123 CHEBI:61904 MNXM1630 +2-hydroxyethane-1-sulfonate [extracellular] C2H5O4S -1 extracellular C05123 CHEBI:61904 MNXM1630 +5-dehydro-D-gluconate [cytoplasm] C6H9O7 -1 cytoplasm C01062 CHEBI:58143 MNXM963 +5-dehydro-D-gluconate [extracellular] C6H9O7 -1 extracellular C01062 CHEBI:58143 MNXM963 +Ala-Asp [extracellular] C7H11N2O5 -1 extracellular CHEBI:74363 MNXM40494 +Ala-Asp [cytoplasm] C7H11N2O5 -1 cytoplasm CHEBI:74363 MNXM40494 +Ala-Asp [vacuole] C7H11N2O5 -1 vacuole CHEBI:74363 MNXM40494 +methyl alpha-D-glucopyranoside [cytoplasm] C7H14O6 0 cytoplasm CHEBI:320061 MNXM61741 +methanol [cytoplasm] CH4O 0 cytoplasm C00132 CHEBI:17790 MNXM157 +methanol [extracellular] CH4O 0 extracellular C00132 CHEBI:17790 MNXM157 +methyl alpha-D-glucopyranoside [extracellular] C7H14O6 0 extracellular CHEBI:320061 MNXM61741 +2',3'-cyclic CMP [cytoplasm] C9H11N3O7P -1 cytoplasm C02354 CHEBI:60877 MNXM3148 +2',3'-cyclic CMP [extracellular] C9H11N3O7P -1 extracellular C02354 CHEBI:60877 MNXM3148 +D-tagatose [cytoplasm] C6H12O6 0 cytoplasm C00795 CHEBI:4249 MNXM92401 +D-tagatofuranose 6-phosphate [cytoplasm] C6H11O9P -2 cytoplasm C01097 CHEBI:58695 MNXM795 +D-tagatose [extracellular] C6H12O6 0 extracellular C00795 CHEBI:4249 MNXM92401 +turanose [extracellular] C12H22O11 0 extracellular C19636 CHEBI:32528 MNXM161984 +acetoacetate [cytoplasm] C4H5O3 -1 cytoplasm C00164 CHEBI:13705 MNXM154 +acetoacetate [extracellular] C4H5O3 -1 extracellular C00164 CHEBI:13705 MNXM154 +N(alpha)-acetyl-L-methionine [cytoplasm] C7H12NO3S -1 cytoplasm C02712 CHEBI:132957 MNXM7576 +N(alpha)-acetyl-L-methionine [extracellular] C7H12NO3S -1 extracellular C02712 CHEBI:132957 MNXM7576 +3-oxalomalate(3-) [cytoplasm] C6H3O8 -3 cytoplasm C01990 CHEBI:15593 MNXM3850 +3-oxalomalate(3-) [extracellular] C6H3O8 -3 extracellular C01990 CHEBI:15593 MNXM3850 +L-cysteate [cytoplasm] C3H6NO5S -1 cytoplasm C00506 CHEBI:58090 MNXM713 +L-cysteate [extracellular] C3H6NO5S -1 extracellular C00506 CHEBI:58090 MNXM713 +alpha-maltotriose [extracellular] C18H32O16 0 extracellular C01835 CHEBI:61993 MNXM468 +2-phospho-D-glyceric acid [extracellular] C3H4O7P -3 extracellular C00631 CHEBI:58289 MNXM275 +3-phosphonato-D-glycerate(3-) [extracellular] C3H4O7P -3 extracellular C00197 CHEBI:58272 MNXM126 +Met-Ala [extracellular] C8H16N2O3S 0 extracellular CHEBI:73610 MNXM61647 +Met-Ala [cytoplasm] C8H16N2O3S 0 cytoplasm CHEBI:73610 MNXM61647 +D-glucose 1-phosphate [extracellular] C6H11O9P -2 extracellular C00103 CHEBI:57629 MNXM89588 +carbamoyl phosphate [extracellular] CH2NO5P -2 extracellular C00169 CHEBI:58228 MNXM138 +3-phospho-serine [extracellular] C3H6NO6P -2 extracellular C01005 CHEBI:57524 MNXM379 +GMP [extracellular] C10H12N5O8P -2 extracellular C00144 CHEBI:58115 MNXM113 +myo-inositol hexakisphosphate [extracellular] C6H6O24P6 -12 extracellular C01204 CHEBI:58130 MNXM491 +D-glucose 6-phosphate [extracellular] C6H11O9P -2 extracellular C00092 CHEBI:61548 MNXM160 +UMP [extracellular] C9H11N2O9P -2 extracellular C00105 CHEBI:57865 MNXM80 +phosphoenolpyruvate [extracellular] C3H2O6P -3 extracellular C00074 CHEBI:58702 MNXM73 +D-mannose 6-phosphate [extracellular] C6H11O9P -2 extracellular C00275 CHEBI:58735 MNXM427 +O-phosphoethanolamine [extracellular] C2H7NO4P -1 extracellular C00346 CHEBI:58190 MNXM187 +6-phospho-D-gluconate [extracellular] C6H10O10P -3 extracellular C00345 CHEBI:58759 MNXM325 +D-mannose 1-phosphate [extracellular] C6H11O9P -2 extracellular C00636 CHEBI:58409 MNXM721 +diphosphate [extracellular] HO7P2 -3 extracellular C00013 CHEBI:33019 MNXM11 +choline phosphate [extracellular] C5H13NO4P -1 extracellular C00588 CHEBI:295975 MNXM229 +thiosulfate [extracellular] HO3S2 -1 extracellular C00320 CHEBI:33542 MNXM323 +AMP [extracellular] C10H12N5O7P -2 extracellular C00020 CHEBI:456215 MNXM14 +2',3'-cyclic AMP [extracellular] C10H11N5O6P -1 extracellular C02353 CHEBI:60879 MNXM2598 +adenosine 2'-phosphate [extracellular] C10H12N5O7P -2 extracellular C00946 CHEBI:77740 MNXM7028 +CMP [extracellular] C9H12N3O8P -2 extracellular C00055 CHEBI:60377 MNXM31 +D-Glucosamine [extracellular] C6H14NO5 1 extracellular C00329 CHEBI:58723 MNXM533 +2-deoxy-D-ribose [extracellular] C5H10O4 0 extracellular C08347 CHEBI:28816 MNXM2474 +L-citrulline [extracellular] C6H13N3O3 0 extracellular C00327 CHEBI:16349 MNXM211 +glycerone [extracellular] C3H6O3 0 extracellular C00184 CHEBI:16016 MNXM460 +Ala-Leu [extracellular] C9H18N2O3 0 extracellular CHEBI:73770 MNXM15786 +Ala-Leu [cytoplasm] C9H18N2O3 0 cytoplasm CHEBI:73770 MNXM15786 +Ala-Gly [extracellular] C5H10N2O3 0 extracellular CHEBI:73757 MNXM15783 +Ala-Gly [cytoplasm] C5H10N2O3 0 cytoplasm CHEBI:73757 MNXM15783 +N-acetyl-L-glutamate [extracellular] C7H9NO5 -2 extracellular C00624 CHEBI:44337 MNXM730 +N-acetyl-L-glutamate [cytoplasm] C7H9NO5 -2 cytoplasm C00624 CHEBI:44337 MNXM730 +lipoamide [extracellular] C8H15NOS2 0 extracellular C00248 CHEBI:17460 MNXM1024 +lipoamide [cytoplasm] C8H15NOS2 0 cytoplasm C00248 CHEBI:17460 MNXM1024 +L-Methionine S-oxide [extracellular] C5H11NO3S 0 extracellular C02989 CHEBI:17016 MNXM2246 +homogentisate [cytoplasm] C8H7O4 -1 cytoplasm C00544 CHEBI:16169 MNXM345 +4-maleylacetoacetate [cytoplasm] C8H6O6 -2 cytoplasm C01036 CHEBI:17105 MNXM691 +4-fumarylacetoacetate [cytoplasm] C8H6O6 -2 cytoplasm C01061 CHEBI:18034 MNXM708 +L-xylulose [cytoplasm] C5H10O5 0 cytoplasm C00310 CHEBI:17140 MNXM597 +D-arabinitol [cytoplasm] C5H12O5 0 cytoplasm C01904 CHEBI:18333 MNXM1018 diff --git a/ComplementaryData/modelCuration/Biolog_newRxnProp.tsv b/ComplementaryData/modelCuration/Biolog_newRxnProp.tsv index 931b7c29..08a3d5b4 100644 --- a/ComplementaryData/modelCuration/Biolog_newRxnProp.tsv +++ b/ComplementaryData/modelCuration/Biolog_newRxnProp.tsv @@ -1,156 +1,156 @@ -rxnID rev GPR rxn_name_seed EC rxnID_kegg Source;reason -MNXR98598 1 glycerol 2-phosphate(2-) transport bigg:EX_glyc2p_e;glycerol 2-phosphate(2-)_P Source -MNXR99852 0 Glycerol-2-phosphate phosphohydrolase 3.1.3.19 R01043 rhea:13105;glycerol 2-phosphate(2-)_P Source -MNXR136678 1 L-Threonine phosphate transport in via proton symport seed:rxn11407;O-phospho-L-threonine_P Source -MNXR103332 0 acid phosphatase / phosphotransferase 3.1.3.- rhea:30579;O-phospho-L-threonine_P Source -MNXR118732 0 alkaline phosphatase 3.1.3.- metacyc:RXN-14512;guanosine 2'-monophosphate_P Source -Guanosine transport via proton symport 1 Guanosine transport via proton symport NA;guanosine 2'-monophosphate_P Source -MNXR94936 0 Guanosine 3'-phosphate phosphohydrolase 3.1.3.6 R02148 rhea:27862;3'-GMP_P Source -Guanosine transport via proton symport(for 3'-GMP) 1 Guanosine transport via proton symport(for 3'-GMP) NA;3'-GMP_P Source -MNXR94822 1 2-Phosphoglycolate transport in/out via proton symport seed:rxn05473;2-phosphoglycolate_P Source -MNXR102543 0 2-phosphoglycolate phosphohydrolase 3.1.3.18 R01334 rhea:14369;2-phosphoglycolate_P Source -MNXR118734 0 alkaline phosphatase 3.1.3.- rhea:37251;cysteamine S-phosphate_P Source -cysteamine S-phosphate transport via proton symport 1 cysteamine S-phosphate transport via proton symport NA;cysteamine S-phosphate_P Source -MNXR107528 0 Cysteamine:oxygen oxidoreductase 1.13.11.19 R02467 rhea:14409;cysteamine S-phosphate_P Source -MNXR107116 0 hypotaurine:NAD+ oxidoreductase 1.8.1.3 R01681 rhea:17385;cysteamine S-phosphate_P Source -MNXR103594 1 2-aminobutanoate:2-oxoglutarate aminotransferase 2.6.1.42 R10991 bigg:RE2034C;2-aminobutanoate_N Source -2-aminobutyrate transport 1 2-aminobutyrate transport NA;2-aminobutanoate_N Source -MNXR118730 0 alkaline phosphatase 3.1.3.- rhea:37355;uridine 2'-phosphate_P Source -MNXR136675 1 Uridine 2'-phosphate transport in via proton symport seed:rxn11403;uridine 2'-phosphate_P Source -MNXR94932 0 Uridine 3'-monophosphate phosphohydrolase 3.1.3.6 R01877 rhea:27890;3'-UMP_P Source -MNXR94982 1 3'-UMP transport in via proton symport seed:rxn05480;3'-UMP_P Source -MNXR137072 1 Gly-Met transport via proton symport seed:rxn12552;Gly-Met_N Source -MNXR123343 0 dipeptidase 3.4.13.18 rhea:37323;Gly-Met_N Source -MNXR111061 0 R07420 R07420 seed:rxn05129;N-phosphocreatine_P Source -N-phosphocreatine transport 1 N-phosphocreatine transport NA;N-phosphocreatine_P Source -creatinine transport 1 creatinine transport NA;N-phosphocreatine_P Source -MNXR95943 1 ATP:L-arginine Nomega-phosphotransferase 2.7.3.3 R00554 rhea:22940;N(omega)-phospho-L-arginine_P Source -MNXR95947 1 L-arginine phosphate transport in/out via proton symport seed:rxn05502;N(omega)-phospho-L-arginine_P Source -MNXR104998 0 acid phosphatase / phosphotransferase rhea:30863;O(4)-phospho-L-tyrosine_P Source -MNXR135003 1 Tripolyphosphate transport in via proton symport seed:rxn05717;triphosphate_P Source -MNXR118731 0 alkaline phosphatase 3.1.3.- rhea:37351;cytidine 2'-phosphate_P Source -MNXR135010 1 Cytidine- 2'- Monophosphate transport in via proton symport seed:rxn05724;cytidine 2'-phosphate_P Source -MNXR117327 0 cyclic phosphodiesterase 3.1.4.37 rhea:37239;2',3'-cyclic UMP_P Source -MNXR136674 1 2',3'-Cyclic UMP transport in via proton symport seed:rxn11402;2',3'-cyclic UMP_P Source -MNXR123155 0 3-Sulfino-L-alanine 4-carboxy-lyase 3.13.1.- R00863 rhea:28278;3-sulfino-L-alanine_S Source -MNXR137086 1 3-Sulfino-L-alanine transport via proton antiport seed:rxn12567;3-sulfino-L-alanine_S Source -MNXR94935 0 adenosine 3'-phosphate phosphohydrolase 3.1.3.6 R01562 rhea:27898;3'-AMP_P Source -MNXR94857 1 3AMP transport via diffusion (extracellular to periplasm) seed:rxn07973;3'-AMP_P Source -MNXR130717 0 alpha-glucosidase 3.2.1.20 sabiork:11700;6-O-alpha-D-glucopyranosyl-D-fructofuranose_C Source -MNXR102339 1 Palatinose transport in via proton symport seed:rxn05629;6-O-alpha-D-glucopyranosyl-D-fructofuranose_C Source -MNXR103637 1 Amino-Acid N-Acetyltransferase bigg:RE2223M;N-acetyl-L-cysteine_S Source -MNXR137052 1 Acetylcysteine transport via proton symport seed:rxn12528;N-acetyl-L-cysteine_S Source -MNXR106345 1 thiosulfate:ferricytochrome-c oxidoreductase 1.8.2.2 R00029;tetrathionate_S Source -MNXR104796 1 etrathionate transport via diffusion bigg:TETtex;tetrathionate_S Source -MNXR95065 0 D-Gluconate:NADP+ 5-oxidoreductase 1.1.1.-;1.1.1.69 R01740 rhea:23936;5-dehydro-D-gluconate_C Source -MNXR95066 1 5-Dehydro-D-gluconate transport via proton symport rhea:28819;5-dehydro-D-gluconate_C Source -MNXR123344 0 dipeptidase 3.4.13.18 rhea:37267;Ala-Asp_N Source -MNXR137135 1 ala-L-asp-L transport via proton symport seed:rxn12628;Ala-Asp_N Source -MNXR117326 0 cyclic phosphodiesterase 3.1.4.37 rhea:41956;cytidine 2'-phosphate_P Source -MNXR136673 1 2',3'-Cyclic CMP transport in via proton symport seed:rxn11401;2',3'-cyclic CMP_P Source -MNXR96247 1 beta-glucosidase (methyl-alpha-D-glucoside) 3.2.1.21 seed:rxn09978;methyl alpha-D-glucopyranoside_C Source -MNXR101464 0 Methanol diffusion rhea:34871;methyl alpha-D-glucopyranoside_C Source -MNXR137048 1 alpha-Methyl-D-glucoside transport via proton symport seed:rxn12524;methyl alpha-D-glucopyranoside_C Source -MNXR107830 0 ATP:D-tagatose 6-phosphotransferase 2.7.1.101 seed:rxn02094;D-tagatose_C Source -R11623 1 D-tagatose 6-phosphate 4-epimerase NA;D-tagatose_C Source -MNXR104707 1 D-tagatose uptake via diffusion bigg:TAGAT_Dt;D-tagatose_C Source -MNXR95136 0 Acetoacetate:CoA ligase (AMP-forming) 6.2.1.16 R01357 rhea:16117;acetoacetate_C Source -MNXR103709 1 N-Acyl-Aliphatic-L-Amino Acid Amidohydrolase 3.5.1.14 bigg:RE2640C;N(alpha)-acetyl-L-methionine_S Source -MNXR137087 1 Ala-Gln transport via proton symport seed:rxn12568;Ala-Gln_N Source -MNXR101006_cv 1 L-alanyl-L-glutamate transport in via proton symport rhea:35131;Ala-Glu_N Source -MNXR101619 0 Maltodextrin glucosidase (maltotriose) 3.2.1.20 seed:rxn05746;alpha-maltotriose_C Source -Ala-Thr transport via proton symport (cytosol to vacuole) 1 Ala-Thr transport via proton symport NA;Ala-Thr_N Source -Ala-Thr transport via proton symport (extracellular to cytosol) 1 Ala-Thr transport via proton symport (extracellular to cytosol) NA;Ala-Thr_N Source -MNXR103069 0 ( YHR201C or YDR452W ) Triphosphate phosphohydrolase 3.6.1.25 R00138 rhea:14157;triphosphate_P Source -Gly-Asn transport via proton symport (extracellular to cytosol) 1 Gly-Asn transport via proton symport (extracellular to cytosol) NA;Gly-Asn_N Source -glycerol 1-phosphate transport 1 glycerol 1-phosphate transport NA;glycerol 1-phosphate_P Source -MNXR103244 1 D-O-Phosphoserine transport in/out via proton symport seed:rxn05639;O-phosphonatooxy-D-serine(2-)_P Source -MNXR103265 1 D-O-Phosphoserine phosphohydrolase 3.1.3.3 R02853 rhea:24873;O-phosphonatooxy-D-serine(2-)_P Source -MNXR101006 1 L-alanyl-L-glutamate transport in via proton symport rhea:35131;Ala-Glu_N Source -MNXR101011 0 L-alanyl-gamma-L-glutamate peptidase 3.4.13.18 rhea:29335;Ala-Glu_N Source -MNXR106549 1 3-oxalomalate glyoxylate-lyase (oxaloacetate-forming) 4.1.3.13 R00477 rhea:22032;3-oxalomalate(3-)_C Source -MNXR111236 0 L-cysteate bisulfite-lyase (deaminating) 4.4.1.25 R07634 rhea:13441;L-cysteate_S Source -MNXR117325 0 cyclic phosphodiesterase 3.1.4.37 rhea:37211;guanosine 2'-monophosphate_P Source -MNXR118741 0 deoxynucleotide 3'-phosphatase 3.1.3.34 rhea:37247;thymidine 3'-monophosphate_P Source -MNXR123345 0 cytosol nonspecific dipeptidase 3.4.13.18 rhea:37275;Ala-Gln_N Source -MNXR123347 0 Cytosol non-specific dipeptidase 3.4.13.18 rhea:37283;Ala-His_N Source -MNXR123349 0 Cytosol non-specific dipeptidase 3.4.13.18 rhea:37299;Ala-Thr_N Source -MNXR123350 0 Cytosol non-specific dipeptidase 3.4.13.18 rhea:37307;Gly-Asn_N Source -MNXR123351 0 Cytosol non-specific dipeptidase 3.4.13.18 rhea:37315;Gly-Gln_N Source -MNXR124424 1 L-Cysteate transport via proton symport seed:rxn12602;L-cysteate_S Source -MNXR130716 1 alpha-glucosidase 3.2.1.20 sabiork:11699;turanose_C Source -MNXR137058 1 2-Hydroxyethanesulfonate transport via proton symport seed:rxn12535;2-hydroxyethane-1-sulfonate_S Source -MNXR137067 1 3-Oxalomalate transport via proton symport seed:rxn12545;3-oxalomalate(3-)_C Source -MNXR137072_cv 1 Gly-Met transport via proton symport seed:rxn12552;Gly-Met_N Source -MNXR137074 1 Gly-Gln transport via proton symport seed:rxn12555;Gly-Gln_N Source -MNXR137074_cv 1 Gly-Gln transport via proton symport seed:rxn12555;Gly-Gln_N Source -MNXR137087_cv 1 Ala-Gln transport via proton symport seed:rxn12568;Ala-Gln_N Source -MNXR137089 1 N-Acetylmethionine transport via proton symport seed:rxn12570;N(alpha)-acetyl-L-methionine_S Source -MNXR137095 1 Phosphotyrosine transport via proton symport seed:rxn12580;O(4)-phospho-L-tyrosine_P Source -MNXR137107 1 Ala-His transport via proton symport seed:rxn12594;Ala-His_N Source -MNXR137107_cv 1 Ala-His transport via proton symport seed:rxn12594;Ala-His_N Source -MNXR137135_cv 1 ala-L-asp-L transport via proton symport seed:rxn12628;Ala-Asp_N Source -MNXR99485 0 FMNH2-dependent alkanesulfonate monooxygenase 1.14.14.5 rhea:29715;2-hydroxyethane-1-sulfonate_S Source -thymidine 3'-monophosphate transport 1 thymidine 3-monophosphate transport NA;thymidine 3'-monophosphate_P Source -thymidine 5'-monophosphate transport 1 thymidine 5-monophosphate transport NA;thymidine 5'-monophosphate_P Source -RHEA:11477 0 ( YIL053W or YER062C ) glycerol-1-phosphate phosphohydrolase R08658 NA;glycerol 1-phosphate_P Source -nucleotide-specific phosphatase (thymidine 5'-monophosphate) 0 nucleotide-specific phosphatase (thymidine 5'-monophosphate) NA;thymidine 5'-monophosphate_P Source -Gly-Glu transport via proton symport (extracellular to cytosol) 1 Gly-Glu transport via proton symport (extracellular to cytosol) NA;Gly-Glu_N Source -Gly-Glu transport via proton symport (cytosol to vacuole) 1 Gly-Glu transport via proton symport (cytosol to vacuole) NA;Gly-Glu_N Source -MNXR123352 0 cytosol nonspecific dipeptidase 3.4.13.18 rhea:36463;Gly-Glu_N Source -L-methionine transport, vacuoluar 1 L-methionine transport, vacuoluar NA;L-methionine_N Source -L-threonine transport, vacuoluar 1 L-threonine transport, vacuoluar NA;L-threonine_N Source -cysteamine exchange 1 cysteamine exchange NA;cysteamine S-phosphate_P Source -MNXR94721 1 23cGMP transport via diffusion (extracellular to periplasm) seed:rxn07927;2',3'-cyclic GMP_P Source -MNXR94824 1 D-Glycerate 2-phosphate transport in/out via proton symport seed:rxn05474;2-phospho-D-glyceric acid_P Source -MNXR94973 1 3-Phospho-D-glycerate transport in/out via proton symport seed:rxn05479;3-phosphonato-D-glycerate(3-)_P Source -MNXR99849 1 D-glucose 1-phosphate transport via diffusion seed:rxn08545;D-glucose 1-phosphate_P Source -MNXR96488 1 carbamoyl phosphate nuclear transport via diffusion seed:rxn09823;carbamoyl phosphate_P Source -Met-Ala transport via proton symport (extracellular to cytosol) 1 Met-Ala transport via proton symport (extracellular to cytosol) NA;Met-Ala_N Source -Met-Ala transport via proton symport (cytosol to vacuole) 1 Met-Ala transport via proton symport (cytosol to vacuole) NA;Met-Ala_N Source -MNXR103245 1 O-Phospho-L-serine transport in via proton symport seed:rxn05640;3-phospho-serine_P Source -MNXR100385 1 GMP transport via proton symport seed:rxn05471;GMP_P Source -MNXR101585 1 myo-inositol phosphate transport via diffusion (extracellular to periplasm) seed:rxn08925;myo-inositol hexakisphosphate_P Source -MNXR98531 1 D-glucose 6-phosphate transport bigg:EX_g6p_e;D-glucose 6-phosphate_P Source -MNXR105127 1 UMP transport rhea:27926;UMP_P Source -MNXR102493 1 Phosphoenolpyruvate transport in via proton symport seed:rxn05630;phosphoenolpyruvate_P Source -MNXR101385 1 Mannose 6-phosphate transport via diffusion (extracellular to periplasm) seed:rxn08880;D-mannose 6-phosphate_P Source -MNXR135002 1 O-Phosphoryl-Ethanolamine transport in via proton symport seed:rxn05716;O-phosphoethanolamine_P Source -MNXR95102 1 6-Phospho-D-gluconate transport in/out via proton symport seed:rxn05482;6-phospho-D-gluconate_P Source -MNXR101377 1 MAN1P transport in/out via proton symport seed:rxn05609;D-mannose 1-phosphate_P Source -MNXR136667 1 Pyrophosphate transport in via proton symport seed:rxn11395;diphosphate_P Source -MNXR96703 1 Choline phosphate intracellular transport bigg:CHOLPtg;choline phosphate_P Source -MNXR104966 1 thiosulfate transport rhea:32807;thiosulfate_S Source -MNXR95831 1 AMP transport in/out via proton symport seed:rxn05497;AMP_P Source -MNXR94718 1 23cAMP transport via diffusion (extracellular to periplasm) seed:rxn07925;2',3'-cyclic AMP_P Source -MNXR135007 1 Adenosine- 2'-Monophosphate transport in via proton symport seed:rxn05721;CMP_P Source -MNXR96805 1 CMP transport in/out via proton symport seed:rxn05525;CMP_P Source -MNXR100035 1 D-glucosamine transport via diffusion (extracellular to periplasm) seed:rxn08593;D-Glucosamine_C Source -2-deoxy-D-ribose transport 1 2-deoxy-D-ribose transport NA;2-deoxy-D-ribose_C Source -MNXR96737 1 L-Citrulline transport in via proton symport seed:rxn05674;L-citrulline_N Source -MNXR97367 1 Dihydroxyacetone transport via facilitated diffusion seed:rxn05532;glycerone_C Source -Ala-Leu transport via proton symport (extracellular to cytosol) 1 Ala-Leu transport via proton symport (extracellular to cytosol) NA;Ala-Leu_N Source -Ala-Leu transport via proton symport (cytosol to vacuole) 1 Ala-Leu transport via proton symport (cytosol to vacuole) NA;Ala-Leu_N Source -MNXR137133 1 L-alanylglycine transport via proton antiport seed:rxn12625;Ala-Gly_N Source -MNXR137133_cv 1 L-alanylglycine transport via proton antiport seed:rxn12625;Ala-Gly_N Source -N-acetyl-L-glutamate transport 1 N-acetyl-L-glutamate transport NA;N-acetyl-L-glutamate_N Source -N-acetyl-L-glutamate transport, mitochondrion 1 N-acetyl-L-glutamate transport NA;N-acetyl-L-glutamate_N Source -MNXR137094 1 Lipoamide transport via proton symport seed:rxn12577;lipoamide_S Source -MNXR101483 1 L-methionine S-oxide transport via diffusion (extracellular) seed:rxn08915;L-Methionine S-oxide_S Source -Gly-Asn transport via proton symport (cytosol to vacuole) 1 Gly-Asn transport via proton symport NA;Gly-Asn_N Source -MNXR137130 1 Cysteamine transport via proton antiport seed:rxn12622;cysteamine S-phosphate_P Source -Hydrogen sulfide oxidation 0 Hydrogen sulfide oxidation NA;general sulfur metabolism_S Source -MNXR95704 1 L-alanine transport in via proton symport rhea:29443;L-alanine_N Source -MNXR100368 1 Glycine transport (vacuole) rhea:28899;L-glycine_N Source -MNXR104382 1 ( YJR130C or YLL058W or YML082W ) O4-succinyl-L-homoserine:hydrogen sulfide S-(3-amino-3-carboxypropyl)transferase; O-succinyl-L-homoserine succinate-lyase (adding hydrogen sulfide) 2.5.1.-;2.5.1.48 R01288 rhea:27826;L-methionine_N Source -MNXR94843 0 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) 1.13.11.27 R02521 rhea:16189;L-tyrosine_N Source -MNXR100628 0 Homogentisate:oxygen 1,2-oxidoreductase (decyclizing) 1.13.11.5 R02519 rhea:15449;L-tyrosine_N Source -MNXR101325 0 4-Maleylacetoacetate cis-trans-isomerase 5.2.1.2 R03181 rhea:14817;L-tyrosine_N Source -MNXR99706 0 4-fumarylacetoacetate fumarylhydrolase 3.7.1.2 R01364 rhea:10244;L-tyrosine_N Source -MNXR95187 0 L-arabinitol:NAD+ 4-oxidoreductase (L-xylulose-forming) 1.1.1.12 R01903 rhea:16381;D-arabinose_C Source -MNXR105265 1 Xylitol:NADP+ 4-oxidoreductase (L-xylulose-forming) 1.1.1.10 R01904 rhea:17025;D-arabinose_C Source -arabinose reductase (D-arabinose) 0 arabinose reductase (D-arabinose) NA;D-arabinose_C Source -MNXR95188 0 D-arabinitol:NAT 4-oxidoreductase 1.1.1.11 R05604 rhea:17921;D-arabinose_C Source -MNXR95208 1 Acetoacetate transport via diffusion rhea:29751;acetoacetate_C Source -MNXR98748 1 methanol exchange bigg:EX_meoh_e;methyl alpha-D-glucopyranoside_C Source -MNXR118733 0 alkaline phosphatase 3.1.3.- rhea:37343;adenosine 2'-phosphate_P Source +rxnID rev GPR rxn_name_seed EC rxnID_kegg Source;reason +MNXR98598 1 glycerol 2-phosphate(2-) transport bigg:EX_glyc2p_e;glycerol 2-phosphate(2-)_P Source +MNXR99852 0 Glycerol-2-phosphate phosphohydrolase 3.1.3.19 R01043 rhea:13105;glycerol 2-phosphate(2-)_P Source +MNXR136678 1 L-Threonine phosphate transport in via proton symport seed:rxn11407;O-phospho-L-threonine_P Source +MNXR103332 0 acid phosphatase / phosphotransferase 3.1.3.- rhea:30579;O-phospho-L-threonine_P Source +MNXR118732 0 alkaline phosphatase 3.1.3.- metacyc:RXN-14512;guanosine 2'-monophosphate_P Source +Guanosine transport via proton symport 1 Guanosine transport via proton symport NA;guanosine 2'-monophosphate_P Source +MNXR94936 0 Guanosine 3'-phosphate phosphohydrolase 3.1.3.6 R02148 rhea:27862;3'-GMP_P Source +Guanosine transport via proton symport(for 3'-GMP) 1 Guanosine transport via proton symport(for 3'-GMP) NA;3'-GMP_P Source +MNXR94822 1 2-Phosphoglycolate transport in/out via proton symport seed:rxn05473;2-phosphoglycolate_P Source +MNXR102543 0 2-phosphoglycolate phosphohydrolase 3.1.3.18 R01334 rhea:14369;2-phosphoglycolate_P Source +MNXR118734 0 alkaline phosphatase 3.1.3.- rhea:37251;cysteamine S-phosphate_P Source +cysteamine S-phosphate transport via proton symport 1 cysteamine S-phosphate transport via proton symport NA;cysteamine S-phosphate_P Source +MNXR107528 0 Cysteamine:oxygen oxidoreductase 1.13.11.19 R02467 rhea:14409;cysteamine S-phosphate_P Source +MNXR107116 0 hypotaurine:NAD+ oxidoreductase 1.8.1.3 R01681 rhea:17385;cysteamine S-phosphate_P Source +MNXR103594 1 2-aminobutanoate:2-oxoglutarate aminotransferase 2.6.1.42 R10991 bigg:RE2034C;2-aminobutanoate_N Source +2-aminobutyrate transport 1 2-aminobutyrate transport NA;2-aminobutanoate_N Source +MNXR118730 0 alkaline phosphatase 3.1.3.- rhea:37355;uridine 2'-phosphate_P Source +MNXR136675 1 Uridine 2'-phosphate transport in via proton symport seed:rxn11403;uridine 2'-phosphate_P Source +MNXR94932 0 Uridine 3'-monophosphate phosphohydrolase 3.1.3.6 R01877 rhea:27890;3'-UMP_P Source +MNXR94982 1 3'-UMP transport in via proton symport seed:rxn05480;3'-UMP_P Source +MNXR137072 1 Gly-Met transport via proton symport seed:rxn12552;Gly-Met_N Source +MNXR123343 0 dipeptidase 3.4.13.18 rhea:37323;Gly-Met_N Source +MNXR111061 0 R07420 R07420 seed:rxn05129;N-phosphocreatine_P Source +N-phosphocreatine transport 1 N-phosphocreatine transport NA;N-phosphocreatine_P Source +creatinine transport 1 creatinine transport NA;N-phosphocreatine_P Source +MNXR95943 1 ATP:L-arginine Nomega-phosphotransferase 2.7.3.3 R00554 rhea:22940;N(omega)-phospho-L-arginine_P Source +MNXR95947 1 L-arginine phosphate transport in/out via proton symport seed:rxn05502;N(omega)-phospho-L-arginine_P Source +MNXR104998 0 acid phosphatase / phosphotransferase rhea:30863;O(4)-phospho-L-tyrosine_P Source +MNXR135003 1 Tripolyphosphate transport in via proton symport seed:rxn05717;triphosphate_P Source +MNXR118731 0 alkaline phosphatase 3.1.3.- rhea:37351;cytidine 2'-phosphate_P Source +MNXR135010 1 Cytidine- 2'- Monophosphate transport in via proton symport seed:rxn05724;cytidine 2'-phosphate_P Source +MNXR117327 0 cyclic phosphodiesterase 3.1.4.37 rhea:37239;2',3'-cyclic UMP_P Source +MNXR136674 1 2',3'-Cyclic UMP transport in via proton symport seed:rxn11402;2',3'-cyclic UMP_P Source +MNXR123155 0 3-Sulfino-L-alanine 4-carboxy-lyase 3.13.1.- R00863 rhea:28278;3-sulfino-L-alanine_S Source +MNXR137086 1 3-Sulfino-L-alanine transport via proton antiport seed:rxn12567;3-sulfino-L-alanine_S Source +MNXR94935 0 adenosine 3'-phosphate phosphohydrolase 3.1.3.6 R01562 rhea:27898;3'-AMP_P Source +MNXR94857 1 3AMP transport via diffusion (extracellular to periplasm) seed:rxn07973;3'-AMP_P Source +MNXR130717 0 alpha-glucosidase 3.2.1.20 sabiork:11700;6-O-alpha-D-glucopyranosyl-D-fructofuranose_C Source +MNXR102339 1 Palatinose transport in via proton symport seed:rxn05629;6-O-alpha-D-glucopyranosyl-D-fructofuranose_C Source +MNXR103637 1 Amino-Acid N-Acetyltransferase bigg:RE2223M;N-acetyl-L-cysteine_S Source +MNXR137052 1 Acetylcysteine transport via proton symport seed:rxn12528;N-acetyl-L-cysteine_S Source +MNXR106345 1 thiosulfate:ferricytochrome-c oxidoreductase 1.8.2.2 R00029;tetrathionate_S Source +MNXR104796 1 etrathionate transport via diffusion bigg:TETtex;tetrathionate_S Source +MNXR95065 0 D-Gluconate:NADP+ 5-oxidoreductase 1.1.1.-;1.1.1.69 R01740 rhea:23936;5-dehydro-D-gluconate_C Source +MNXR95066 1 5-Dehydro-D-gluconate transport via proton symport rhea:28819;5-dehydro-D-gluconate_C Source +MNXR123344 0 dipeptidase 3.4.13.18 rhea:37267;Ala-Asp_N Source +MNXR137135 1 ala-L-asp-L transport via proton symport seed:rxn12628;Ala-Asp_N Source +MNXR117326 0 cyclic phosphodiesterase 3.1.4.37 rhea:41956;cytidine 2'-phosphate_P Source +MNXR136673 1 2',3'-Cyclic CMP transport in via proton symport seed:rxn11401;2',3'-cyclic CMP_P Source +MNXR96247 1 beta-glucosidase (methyl-alpha-D-glucoside) 3.2.1.21 seed:rxn09978;methyl alpha-D-glucopyranoside_C Source +MNXR101464 0 Methanol diffusion rhea:34871;methyl alpha-D-glucopyranoside_C Source +MNXR137048 1 alpha-Methyl-D-glucoside transport via proton symport seed:rxn12524;methyl alpha-D-glucopyranoside_C Source +MNXR107830 0 ATP:D-tagatose 6-phosphotransferase 2.7.1.101 seed:rxn02094;D-tagatose_C Source +R11623 1 D-tagatose 6-phosphate 4-epimerase NA;D-tagatose_C Source +MNXR104707 1 D-tagatose uptake via diffusion bigg:TAGAT_Dt;D-tagatose_C Source +MNXR95136 0 Acetoacetate:CoA ligase (AMP-forming) 6.2.1.16 R01357 rhea:16117;acetoacetate_C Source +MNXR103709 1 N-Acyl-Aliphatic-L-Amino Acid Amidohydrolase 3.5.1.14 bigg:RE2640C;N(alpha)-acetyl-L-methionine_S Source +MNXR137087 1 Ala-Gln transport via proton symport seed:rxn12568;Ala-Gln_N Source +MNXR101006_cv 1 L-alanyl-L-glutamate transport in via proton symport rhea:35131;Ala-Glu_N Source +MNXR101619 0 Maltodextrin glucosidase (maltotriose) 3.2.1.20 seed:rxn05746;alpha-maltotriose_C Source +Ala-Thr transport via proton symport (cytosol to vacuole) 1 Ala-Thr transport via proton symport NA;Ala-Thr_N Source +Ala-Thr transport via proton symport (extracellular to cytosol) 1 Ala-Thr transport via proton symport (extracellular to cytosol) NA;Ala-Thr_N Source +MNXR103069 0 ( YHR201C or YDR452W ) Triphosphate phosphohydrolase 3.6.1.25 R00138 rhea:14157;triphosphate_P Source +Gly-Asn transport via proton symport (extracellular to cytosol) 1 Gly-Asn transport via proton symport (extracellular to cytosol) NA;Gly-Asn_N Source +glycerol 1-phosphate transport 1 glycerol 1-phosphate transport NA;glycerol 1-phosphate_P Source +MNXR103244 1 D-O-Phosphoserine transport in/out via proton symport seed:rxn05639;O-phosphonatooxy-D-serine(2-)_P Source +MNXR103265 1 D-O-Phosphoserine phosphohydrolase 3.1.3.3 R02853 rhea:24873;O-phosphonatooxy-D-serine(2-)_P Source +MNXR101006 1 L-alanyl-L-glutamate transport in via proton symport rhea:35131;Ala-Glu_N Source +MNXR101011 0 L-alanyl-gamma-L-glutamate peptidase 3.4.13.18 rhea:29335;Ala-Glu_N Source +MNXR106549 1 3-oxalomalate glyoxylate-lyase (oxaloacetate-forming) 4.1.3.13 R00477 rhea:22032;3-oxalomalate(3-)_C Source +MNXR111236 0 L-cysteate bisulfite-lyase (deaminating) 4.4.1.25 R07634 rhea:13441;L-cysteate_S Source +MNXR117325 0 cyclic phosphodiesterase 3.1.4.37 rhea:37211;guanosine 2'-monophosphate_P Source +MNXR118741 0 deoxynucleotide 3'-phosphatase 3.1.3.34 rhea:37247;thymidine 3'-monophosphate_P Source +MNXR123345 0 cytosol nonspecific dipeptidase 3.4.13.18 rhea:37275;Ala-Gln_N Source +MNXR123347 0 Cytosol non-specific dipeptidase 3.4.13.18 rhea:37283;Ala-His_N Source +MNXR123349 0 Cytosol non-specific dipeptidase 3.4.13.18 rhea:37299;Ala-Thr_N Source +MNXR123350 0 Cytosol non-specific dipeptidase 3.4.13.18 rhea:37307;Gly-Asn_N Source +MNXR123351 0 Cytosol non-specific dipeptidase 3.4.13.18 rhea:37315;Gly-Gln_N Source +MNXR124424 1 L-Cysteate transport via proton symport seed:rxn12602;L-cysteate_S Source +MNXR130716 1 alpha-glucosidase 3.2.1.20 sabiork:11699;turanose_C Source +MNXR137058 1 2-Hydroxyethanesulfonate transport via proton symport seed:rxn12535;2-hydroxyethane-1-sulfonate_S Source +MNXR137067 1 3-Oxalomalate transport via proton symport seed:rxn12545;3-oxalomalate(3-)_C Source +MNXR137072_cv 1 Gly-Met transport via proton symport seed:rxn12552;Gly-Met_N Source +MNXR137074 1 Gly-Gln transport via proton symport seed:rxn12555;Gly-Gln_N Source +MNXR137074_cv 1 Gly-Gln transport via proton symport seed:rxn12555;Gly-Gln_N Source +MNXR137087_cv 1 Ala-Gln transport via proton symport seed:rxn12568;Ala-Gln_N Source +MNXR137089 1 N-Acetylmethionine transport via proton symport seed:rxn12570;N(alpha)-acetyl-L-methionine_S Source +MNXR137095 1 Phosphotyrosine transport via proton symport seed:rxn12580;O(4)-phospho-L-tyrosine_P Source +MNXR137107 1 Ala-His transport via proton symport seed:rxn12594;Ala-His_N Source +MNXR137107_cv 1 Ala-His transport via proton symport seed:rxn12594;Ala-His_N Source +MNXR137135_cv 1 ala-L-asp-L transport via proton symport seed:rxn12628;Ala-Asp_N Source +MNXR99485 0 FMNH2-dependent alkanesulfonate monooxygenase 1.14.14.5 rhea:29715;2-hydroxyethane-1-sulfonate_S Source +thymidine 3'-monophosphate transport 1 thymidine 3-monophosphate transport NA;thymidine 3'-monophosphate_P Source +thymidine 5'-monophosphate transport 1 thymidine 5-monophosphate transport NA;thymidine 5'-monophosphate_P Source +RHEA:11477 0 ( YIL053W or YER062C ) glycerol-1-phosphate phosphohydrolase R08658 NA;glycerol 1-phosphate_P Source +nucleotide-specific phosphatase (thymidine 5'-monophosphate) 0 nucleotide-specific phosphatase (thymidine 5'-monophosphate) NA;thymidine 5'-monophosphate_P Source +Gly-Glu transport via proton symport (extracellular to cytosol) 1 Gly-Glu transport via proton symport (extracellular to cytosol) NA;Gly-Glu_N Source +Gly-Glu transport via proton symport (cytosol to vacuole) 1 Gly-Glu transport via proton symport (cytosol to vacuole) NA;Gly-Glu_N Source +MNXR123352 0 cytosol nonspecific dipeptidase 3.4.13.18 rhea:36463;Gly-Glu_N Source +L-methionine transport, vacuoluar 1 L-methionine transport, vacuoluar NA;L-methionine_N Source +L-threonine transport, vacuoluar 1 L-threonine transport, vacuoluar NA;L-threonine_N Source +cysteamine exchange 1 cysteamine exchange NA;cysteamine S-phosphate_P Source +MNXR94721 1 23cGMP transport via diffusion (extracellular to periplasm) seed:rxn07927;2',3'-cyclic GMP_P Source +MNXR94824 1 D-Glycerate 2-phosphate transport in/out via proton symport seed:rxn05474;2-phospho-D-glyceric acid_P Source +MNXR94973 1 3-Phospho-D-glycerate transport in/out via proton symport seed:rxn05479;3-phosphonato-D-glycerate(3-)_P Source +MNXR99849 1 D-glucose 1-phosphate transport via diffusion seed:rxn08545;D-glucose 1-phosphate_P Source +MNXR96488 1 carbamoyl phosphate nuclear transport via diffusion seed:rxn09823;carbamoyl phosphate_P Source +Met-Ala transport via proton symport (extracellular to cytosol) 1 Met-Ala transport via proton symport (extracellular to cytosol) NA;Met-Ala_N Source +Met-Ala transport via proton symport (cytosol to vacuole) 1 Met-Ala transport via proton symport (cytosol to vacuole) NA;Met-Ala_N Source +MNXR103245 1 O-Phospho-L-serine transport in via proton symport seed:rxn05640;3-phospho-serine_P Source +MNXR100385 1 GMP transport via proton symport seed:rxn05471;GMP_P Source +MNXR101585 1 myo-inositol phosphate transport via diffusion (extracellular to periplasm) seed:rxn08925;myo-inositol hexakisphosphate_P Source +MNXR98531 1 D-glucose 6-phosphate transport bigg:EX_g6p_e;D-glucose 6-phosphate_P Source +MNXR105127 1 UMP transport rhea:27926;UMP_P Source +MNXR102493 1 Phosphoenolpyruvate transport in via proton symport seed:rxn05630;phosphoenolpyruvate_P Source +MNXR101385 1 Mannose 6-phosphate transport via diffusion (extracellular to periplasm) seed:rxn08880;D-mannose 6-phosphate_P Source +MNXR135002 1 O-Phosphoryl-Ethanolamine transport in via proton symport seed:rxn05716;O-phosphoethanolamine_P Source +MNXR95102 1 6-Phospho-D-gluconate transport in/out via proton symport seed:rxn05482;6-phospho-D-gluconate_P Source +MNXR101377 1 MAN1P transport in/out via proton symport seed:rxn05609;D-mannose 1-phosphate_P Source +MNXR136667 1 Pyrophosphate transport in via proton symport seed:rxn11395;diphosphate_P Source +MNXR96703 1 Choline phosphate intracellular transport bigg:CHOLPtg;choline phosphate_P Source +MNXR104966 1 thiosulfate transport rhea:32807;thiosulfate_S Source +MNXR95831 1 AMP transport in/out via proton symport seed:rxn05497;AMP_P Source +MNXR94718 1 23cAMP transport via diffusion (extracellular to periplasm) seed:rxn07925;2',3'-cyclic AMP_P Source +MNXR135007 1 Adenosine- 2'-Monophosphate transport in via proton symport seed:rxn05721;CMP_P Source +MNXR96805 1 CMP transport in/out via proton symport seed:rxn05525;CMP_P Source +MNXR100035 1 D-glucosamine transport via diffusion (extracellular to periplasm) seed:rxn08593;D-Glucosamine_C Source +2-deoxy-D-ribose transport 1 2-deoxy-D-ribose transport NA;2-deoxy-D-ribose_C Source +MNXR96737 1 L-Citrulline transport in via proton symport seed:rxn05674;L-citrulline_N Source +MNXR97367 1 Dihydroxyacetone transport via facilitated diffusion seed:rxn05532;glycerone_C Source +Ala-Leu transport via proton symport (extracellular to cytosol) 1 Ala-Leu transport via proton symport (extracellular to cytosol) NA;Ala-Leu_N Source +Ala-Leu transport via proton symport (cytosol to vacuole) 1 Ala-Leu transport via proton symport (cytosol to vacuole) NA;Ala-Leu_N Source +MNXR137133 1 L-alanylglycine transport via proton antiport seed:rxn12625;Ala-Gly_N Source +MNXR137133_cv 1 L-alanylglycine transport via proton antiport seed:rxn12625;Ala-Gly_N Source +N-acetyl-L-glutamate transport 1 N-acetyl-L-glutamate transport NA;N-acetyl-L-glutamate_N Source +N-acetyl-L-glutamate transport, mitochondrion 1 N-acetyl-L-glutamate transport NA;N-acetyl-L-glutamate_N Source +MNXR137094 1 Lipoamide transport via proton symport seed:rxn12577;lipoamide_S Source +MNXR101483 1 L-methionine S-oxide transport via diffusion (extracellular) seed:rxn08915;L-Methionine S-oxide_S Source +Gly-Asn transport via proton symport (cytosol to vacuole) 1 Gly-Asn transport via proton symport NA;Gly-Asn_N Source +MNXR137130 1 Cysteamine transport via proton antiport seed:rxn12622;cysteamine S-phosphate_P Source +Hydrogen sulfide oxidation 0 Hydrogen sulfide oxidation NA;general sulfur metabolism_S Source +MNXR95704 1 L-alanine transport in via proton symport rhea:29443;L-alanine_N Source +MNXR100368 1 Glycine transport (vacuole) rhea:28899;L-glycine_N Source +MNXR104382 1 ( YJR130C or YLL058W or YML082W ) O4-succinyl-L-homoserine:hydrogen sulfide S-(3-amino-3-carboxypropyl)transferase; O-succinyl-L-homoserine succinate-lyase (adding hydrogen sulfide) 2.5.1.-;2.5.1.48 R01288 rhea:27826;L-methionine_N Source +MNXR94843 0 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) 1.13.11.27 R02521 rhea:16189;L-tyrosine_N Source +MNXR100628 0 Homogentisate:oxygen 1,2-oxidoreductase (decyclizing) 1.13.11.5 R02519 rhea:15449;L-tyrosine_N Source +MNXR101325 0 4-Maleylacetoacetate cis-trans-isomerase 5.2.1.2 R03181 rhea:14817;L-tyrosine_N Source +MNXR99706 0 4-fumarylacetoacetate fumarylhydrolase 3.7.1.2 R01364 rhea:10244;L-tyrosine_N Source +MNXR95187 0 L-arabinitol:NAD+ 4-oxidoreductase (L-xylulose-forming) 1.1.1.12 R01903 rhea:16381;D-arabinose_C Source +MNXR105265 1 Xylitol:NADP+ 4-oxidoreductase (L-xylulose-forming) 1.1.1.10 R01904 rhea:17025;D-arabinose_C Source +arabinose reductase (D-arabinose) 0 arabinose reductase (D-arabinose) NA;D-arabinose_C Source +MNXR95188 0 D-arabinitol:NAT 4-oxidoreductase 1.1.1.11 R05604 rhea:17921;D-arabinose_C Source +MNXR95208 1 Acetoacetate transport via diffusion rhea:29751;acetoacetate_C Source +MNXR98748 1 methanol exchange bigg:EX_meoh_e;methyl alpha-D-glucopyranoside_C Source +MNXR118733 0 alkaline phosphatase 3.1.3.- rhea:37343;adenosine 2'-phosphate_P Source diff --git a/ComplementaryData/modelCuration/Biomass_newRxnMatrix.tsv b/ComplementaryData/modelCuration/Biomass_newRxnMatrix.tsv index 63d8de54..099def49 100644 --- a/ComplementaryData/modelCuration/Biomass_newRxnMatrix.tsv +++ b/ComplementaryData/modelCuration/Biomass_newRxnMatrix.tsv @@ -1,29 +1,29 @@ -rxnID coefficient Metabolite standard name Metabolite_type compartment -MNXR96437 1 Ca(2+) reactant extracellular -MNXR96437 1 H+ reactant extracellular -MNXR96437 1 Ca(2+) product cytoplasm -MNXR96437 1 H+ product cytoplasm -MNXR96797 1 chloride reactant extracellular -MNXR96797 1 chloride product cytoplasm -MNXR126350 1 Cu2(+) reactant extracellular -MNXR126350 1 H+ reactant extracellular -MNXR126350 1 Cu2(+) product cytoplasm -MNXR126350 1 H+ product cytoplasm -MNXR101669 1 Mn(2+) reactant extracellular -MNXR101669 1 H+ reactant extracellular -MNXR101669 1 Mn(2+) product cytoplasm -MNXR101669 1 H+ product cytoplasm -MNXR105278 1 Zn(2+) reactant extracellular -MNXR105278 1 H+ reactant extracellular -MNXR105278 1 Zn(2+) product cytoplasm -MNXR105278 1 H+ product cytoplasm -MNXR101553 1 Mg(2+) reactant extracellular -MNXR101553 1 H+ reactant extracellular -MNXR101553 1 Mg(2+) product cytoplasm -MNXR101553 1 H+ product cytoplasm -chloride exchange 1 chloride reactant extracellular -Cu2(+) exchange 1 Cu2(+) reactant extracellular -Mn(2+) exchange 1 Mn(2+) reactant extracellular -Zn(2+) exchange 1 Zn(2+) reactant extracellular -Mg(2+) exchange 1 Mg(2+) reactant extracellular -Ca(2+) exchange 1 Ca(2+) reactant extracellular +rxnID coefficient Metabolite standard name Metabolite_type compartment +MNXR96437 1 Ca(2+) reactant extracellular +MNXR96437 1 H+ reactant extracellular +MNXR96437 1 Ca(2+) product cytoplasm +MNXR96437 1 H+ product cytoplasm +MNXR96797 1 chloride reactant extracellular +MNXR96797 1 chloride product cytoplasm +MNXR126350 1 Cu2(+) reactant extracellular +MNXR126350 1 H+ reactant extracellular +MNXR126350 1 Cu2(+) product cytoplasm +MNXR126350 1 H+ product cytoplasm +MNXR101669 1 Mn(2+) reactant extracellular +MNXR101669 1 H+ reactant extracellular +MNXR101669 1 Mn(2+) product cytoplasm +MNXR101669 1 H+ product cytoplasm +MNXR105278 1 Zn(2+) reactant extracellular +MNXR105278 1 H+ reactant extracellular +MNXR105278 1 Zn(2+) product cytoplasm +MNXR105278 1 H+ product cytoplasm +MNXR101553 1 Mg(2+) reactant extracellular +MNXR101553 1 H+ reactant extracellular +MNXR101553 1 Mg(2+) product cytoplasm +MNXR101553 1 H+ product cytoplasm +chloride exchange 1 chloride reactant extracellular +Cu2(+) exchange 1 Cu2(+) reactant extracellular +Mn(2+) exchange 1 Mn(2+) reactant extracellular +Zn(2+) exchange 1 Zn(2+) reactant extracellular +Mg(2+) exchange 1 Mg(2+) reactant extracellular +Ca(2+) exchange 1 Ca(2+) reactant extracellular diff --git a/ComplementaryData/modelCuration/Biomass_newRxnMet.tsv b/ComplementaryData/modelCuration/Biomass_newRxnMet.tsv index b7fe85d2..be8451f4 100644 --- a/ComplementaryData/modelCuration/Biomass_newRxnMet.tsv +++ b/ComplementaryData/modelCuration/Biomass_newRxnMet.tsv @@ -1,7 +1,7 @@ -NewMetName Charged formula Charge compartment KEGG ID CHEBI ID Remark -Ca(2+) [extracellular] Ca 2 extracellular C00076 CHEBI:29108 -chloride [extracellular] Cl -1 extracellular C00698 CHEBI:17996 -Cu2(+) [extracellular] Cu 2 extracellular C00070 CHEBI:29036 -Mn(2+) [extracellular] Mn 2 extracellular C19610 CHEBI:29035 -Zn(2+) [extracellular] Zn 2 extracellular C00038 CHEBI:29105 -Mg(2+) [extracellular] Mg 2 extracellular C00305 CHEBI:18420 +NewMetName Charged formula Charge compartment KEGG ID CHEBI ID Remark +Ca(2+) [extracellular] Ca 2 extracellular C00076 CHEBI:29108 +chloride [extracellular] Cl -1 extracellular C00698 CHEBI:17996 +Cu2(+) [extracellular] Cu 2 extracellular C00070 CHEBI:29036 +Mn(2+) [extracellular] Mn 2 extracellular C19610 CHEBI:29035 +Zn(2+) [extracellular] Zn 2 extracellular C00038 CHEBI:29105 +Mg(2+) [extracellular] Mg 2 extracellular C00305 CHEBI:18420 diff --git a/ComplementaryData/modelCuration/Biomass_newRxnProp.tsv b/ComplementaryData/modelCuration/Biomass_newRxnProp.tsv index fafebfc6..8dcd44b1 100644 --- a/ComplementaryData/modelCuration/Biomass_newRxnProp.tsv +++ b/ComplementaryData/modelCuration/Biomass_newRxnProp.tsv @@ -1,13 +1,13 @@ -rxnID rev GPR rxn_name_seed EC rxnID_kegg Source;reason -MNXR96437 1 YOL122C Ca(2+) transport bigg:CAt4; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) -MNXR96797 1 YNL275W chloride transport bigg:Clt; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) -MNXR126350 1 YOL122C Cu2(+) transport rhea:28727; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) -MNXR101669 1 YGR191W Mn(2+) transport seed:rxn08946; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) -MNXR105278 1 ( YGL255W or YLR130C ) Zn(2+) transport bigg:ZN2t3pp; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) -MNXR101553 1 ( GR191W or YOL130W ) Mg(2+) transport bigg:MGt2pp; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) -chloride exchange 1 chloride exchange -Cu2(+) exchange 1 Cu2(+) exchange -Mn(2+) exchange 1 Mn(2+) exchange -Zn(2+) exchange 1 Zn(2+) exchange -Mg(2+) exchange 1 Mg(2+) exchange -Ca(2+) exchange 1 Ca(2+) exchange +rxnID rev GPR rxn_name_seed EC rxnID_kegg Source;reason +MNXR96437 1 YOL122C Ca(2+) transport bigg:CAt4; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) +MNXR96797 1 YNL275W chloride transport bigg:Clt; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) +MNXR126350 1 YOL122C Cu2(+) transport rhea:28727; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) +MNXR101669 1 YGR191W Mn(2+) transport seed:rxn08946; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) +MNXR105278 1 ( YGL255W or YLR130C ) Zn(2+) transport bigg:ZN2t3pp; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) +MNXR101553 1 ( GR191W or YOL130W ) Mg(2+) transport bigg:MGt2pp; gRrules come from TCDB, not included in the DBnewAnnotaiton update (PR #142) +chloride exchange 1 chloride exchange +Cu2(+) exchange 1 Cu2(+) exchange +Mn(2+) exchange 1 Mn(2+) exchange +Zn(2+) exchange 1 Zn(2+) exchange +Mg(2+) exchange 1 Mg(2+) exchange +Ca(2+) exchange 1 Ca(2+) exchange diff --git a/ComplementaryData/modelCuration/DBnewRxnMetAnnotation.tsv b/ComplementaryData/modelCuration/DBnewRxnMetAnnotation.tsv index 0dab696b..138b80a8 100755 --- a/ComplementaryData/modelCuration/DBnewRxnMetAnnotation.tsv +++ b/ComplementaryData/modelCuration/DBnewRxnMetAnnotation.tsv @@ -1,281 +1,281 @@ -NewMetName Charged formula Charge compartment KEGG ID CHEBI ID Remark -Cytochrome c [mitochondrion] C40H40FeN6O6S2 -2 mitochondrion C00524 CHEBI:83739 based on Rhea -Apocytochrome c [mitochondrion] C6H10N2O2S2 0 mitochondrion C02248 CHEBI:15697 based on Rhea -diacetyl [cytoplasm] C4H6O2 0 cytoplasm C00741 CHEBI:16583 based on metnx -(R)-acetoin [nucleus] C4H8O2 0 nucleus C00810 CHEBI:15686 based on metnx -diacetyl [nucleus] C4H6O2 0 nucleus C00741 CHEBI:16583 based on metnx -NADH [nucleus] C21H27N7O14P2 -2 nucleus C00004 CHEBI:57945 Present in yeast model -L-glutamyl-tRNA(Gln) [mitochondrion] C20H28N6O13PR 0 mitochondrion C06112 CHEBI:29165 based on kegg -L-glutamine [mitochondrion] C5H10N2O3 0 mitochondrion C00064 CHEBI:18050 based on chebi -Gln-tRNA(Gln) [mitochondrion] C20H29N7O12PR 0 mitochondrion C02282 CHEBI:29166 based on kegg -Met-Ala [vacuole] C8H16N2O3S 0 vacuole CHEBI:73610 based on chebi -ADP-D-ribose 1''-phosphate [cytoplasm] C15H20N5O17P3 -4 cytoplasm CHEBI:58753 based on chebi -ADP-ribose [cytoplasm] C15H21N5O14P2 -2 cytoplasm C00301 CHEBI:57967 Present in yeast model -quinone [cytoplasm] C6H4O2 0 cytoplasm C00472 CHEBI:16509 based on chebi -1,4-benzosemiquinone [cytoplasm] C6H5O2 0 cytoplasm CHEBI:17977 based on chebi -UDP-N-acetyl-alpha-D-glucosamine [endoplasmic reticulum] C17H25N3O17P2 -2 endoplasmic reticulum C00043 CHEBI:57705 Present in yeast model -N-Acetyl-D-glucosaminyldiphosphodolichol [endoplasmic reticulum] C28H51NO12P2R 0 endoplasmic reticulum C04500 CHEBI:18278 based on chebi -UDP [endoplasmic reticulum] C9H11N2O12P2 -3 endoplasmic reticulum C00015 CHEBI:58223 Present in yeast model -N,N'-Chitobiosyldiphosphodolichol [endoplasmic reticulum] C36H64N2O17P2R 0 endoplasmic reticulum based on kegg, G00002 -D-ribofuranose 5-phosphate [cytoplasm] C5H9O8P -2 cytoplasm CHEBI:78346 based on chebi -Oxalate [peroxisome] C2O4 -2 peroxisome C00209 CHEBI:30623 based on metnx -Oxalyl-CoA [peroxisome] C23H31N7O19P3S -5 peroxisome C00313 CHEBI:57388 based on chebi -G00171 [endoplasmic reticulum] C86H142N4O67R 0 endoplasmic reticulum based on kegg, G00171 -D-glucose [endoplasmic reticulum] C6H12O6 0 endoplasmic reticulum C00031 CHEBI:4167 based on metnx -G00010 [endoplasmic reticulum] C80H132N4O62R 0 endoplasmic reticulum based on kegg, G00010 -G00011 [endoplasmic reticulum] C74H122N4O57R 0 endoplasmic reticulum based on kegg, G00011 -sodium [vacuole] Na 1 vacuole C01330 CHEBI:29101 based on metnx -potassium [vacuole] K 1 vacuole C00238 CHEBI:29103 based on metnx -chloride [vacuole] Cl -1 vacuole C00698 CHEBI:17996 based on metnx -chloride [cytoplasm] Cl -1 cytoplasm C00698 CHEBI:17996 based on metnx -D-fructose [vacuole] C6H12O6 0 vacuole C00095 CHEBI:15824 based on chebi -D-galactose [vacuole] C6H12O6 0 vacuole C00124 CHEBI:4139 based on chebi -UMP [endoplasmic reticulum] C9H11N2O9P -2 endoplasmic reticulum C00105 CHEBI:57865 Present in yeast model -cadmium(2+) [cytoplasm] Cd 2 cytoplasm CHEBI:48775 based on chebi -cadmium(2+) [extracellular] Cd 2 extracellular CHEBI:48775 based on chebi -(sulfur carrier)-H [mitochondrion] R 0 mitochondrion General type -L-cysteine [mitochondrion] C3H7NO2S 0 mitochondrion C00097 CHEBI:17561 based on chebi -(sulfur carrier)-SH [mitochondrion] SR 0 mitochondrion General type -cholesterol [endoplasmic reticulum] C27H46O 0 endoplasmic reticulum C00187 CHEBI:16113 based on metnx -cholesterol [endoplasmic reticulum membrane] C27H46O 0 endoplasmic reticulum membrane C00187 CHEBI:16113 based on metnx -3-chlorobenzyl alcohol [cytoplasm] C7H7ClO 0 cytoplasm PubChem CID, 70117 -3-chlorobenzaldehyde [cytoplasm] C7H5ClO 0 cytoplasm PubChem CID, 70117 -3-hydroxybenzyl alcohol [cytoplasm] C7H8O2 0 cytoplasm C03351 CHEBI:17069 based on metnx -3-hydroxybenzaldehyde [cytoplasm] C7H6O2 0 cytoplasm C03067 CHEBI:16207 based on metnx -3-methylbenzyl alcohol [cytoplasm] C8H10O 0 cytoplasm C07216 CHEBI:27995 based on metnx -3-methylbenzaldehyde [cytoplasm] C8H8O 0 cytoplasm C07209 CHEBI:28476 based on metnx -4-isopropylbenzyl alcohol [cytoplasm] C10H14O 0 cytoplasm CHEBI:27628 based on chebi -p-cumic aldehyde [cytoplasm] C10H12O 0 cytoplasm C06577 CHEBI:28671 based on metnx -4-methylbenzyl alcohol [cytoplasm] C8H10O 0 cytoplasm C06757 CHEBI:1895 based on metnx -4-methylbenzaldehyde [cytoplasm] C8H8O 0 cytoplasm C06758 CHEBI:28617 based on metnx -benzyl alcohol [cytoplasm] C7H8O 0 cytoplasm C00556 CHEBI:17987 based on metnx -benzaldehyde [cytoplasm] C7H6O 0 cytoplasm C00261 CHEBI:17169 based on metnx -Mn(2+) [cytoplasm] Mn 2 cytoplasm C19610 CHEBI:29035 based on chebi -Mn(2+) [endoplasmic reticulum] Mn 2 endoplasmic reticulum C19610 CHEBI:29035 based on chebi -[protein]-L-lysine [cytoplasm] C6H13N2O 1 cytoplasm C02188 CHEBI:29969 based on Rhea and chebi -[protein]-N(6)-acetyl-L-lysine [cytoplasm] C8H14N2O2 0 cytoplasm CHEBI:61930 based on Rhea -Mannitol [cytoplasm] C6H14O6 0 cytoplasm C00392 CHEBI:16899 based on metnx -4-hydroxy-4-methyl-2-oxoglutarate [cytoplasm] C6H6O6 -2 cytoplasm C06033 CHEBI:58276 based on chebi and Rhea -L-methionine (S)-S-oxide [cytoplasm] C5H11NO3S 0 cytoplasm C15999 CHEBI:49031 based on chebi -tRNA(Pro) [mitochondrion] R -1 mitochondrion C01649 CHEBI:29177 Present in yeast model -Pro-tRNA(Pro) [mitochondrion] C5H8NOR 0 mitochondrion C02702 CHEBI:29154 Present in yeast model -5-oxo-L-proline [cytoplasm] C5H6NO3 -1 cytoplasm C01879 CHEBI:58402 based on chebi -4a-Hydroxytetrahydrobiopterin [mitochondrion] C9H15N5O4 0 mitochondrion C15522 CHEBI:15642 based on metnx -Dihydrobiopterin [mitochondrion] C9H13N5O3 0 mitochondrion C00268 CHEBI:20680 based on metnx -superoxide [mitochondrion] O2 -1 mitochondrion C00704 CHEBI:18421 based on metnx -2-deoxy-D-glucose 6-phosphate [cytoplasm] C6H11O8P -2 cytoplasm C06369 CHEBI:84760 based on chebi -2-deoxy-D-glucose [cytoplasm] C6H12O5 0 cytoplasm C00586 CHEBI:84755 based on chebi -[cytochrome c]-L-lysine [cytoplasm] C6H13N2O 1 cytoplasm CHEBI:29969 based on kegg and Rhea -[cytochrome c]-N6-methyl-L-lysine [cytoplasm] C7H15N2O 1 cytoplasm CHEBI:61929 based on kegg and Rhea -S-adenosyl-L-methionine [nucleus] C15H23N6O5S 1 nucleus C00019 CHEBI:67040 Present in yeast model -L-lysine-[histone] [nucleus] C6H13N2OR2 1 nucleus CHEBI:29969 General type, based on metanetx MNXM59465 -S-adenosyl-L-homocysteine [nucleus] C14H20N6O5S 0 nucleus C00021 CHEBI:16680 based on chebi -N6-methyl-L-lysine-[histone] [nucleus] C7H15N2OR2 1 nucleus CHEBI:61929 General type, Histone N6-methyl-L-lysine, C03702, based on metanetx MNXM63025 -Zn(2+) [cytoplasm] Zn 2 cytoplasm C00038 CHEBI:29105 based on metnx -Zn(2+) [endoplasmic reticulum] Zn 2 endoplasmic reticulum C00038 CHEBI:29105 based on metnx -Ferricytochrome b5 [endoplasmic reticulum] Fe 3 endoplasmic reticulum C00996 CHEBI:18097 based on kegg and Rhea -Ferrocytochrome b5 [endoplasmic reticulum] Fe 2 endoplasmic reticulum C00999 based on kegg and Rhea -Ferricytochrome b5 [mitochondrion] Fe 3 mitochondrion C00996 CHEBI:18097 based on kegg and Rhea -Ferrocytochrome b5 [mitochondrion] Fe 2 mitochondrion C00999 based on kegg and Rhea -(S)-benzoin [cytoplasm] C14H12O2 0 cytoplasm C20227 based on kegg and Rhea -benzil [cytoplasm] C14H10O2 0 cytoplasm C20226 CHEBI:51507 based on metnx -RX [endoplasmic reticulum] RX 0 endoplasmic reticulum C01322 CHEBI:17792 based on metnx -glutathione [endoplasmic reticulum] C10H16N3O6S -1 endoplasmic reticulum C00051 CHEBI:57925 Present in yeast model -HX [endoplasmic reticulum] X -1 endoplasmic reticulum C00462 CHEBI:16042 based on metnx -R-S-glutathione [endoplasmic reticulum] C10H16N3O6SR 0 endoplasmic reticulum C02320 CHEBI:17021 based on kegg -RX [cytoplasm] RX 0 cytoplasm C01322 CHEBI:17792 based on metnx -HX [cytoplasm] X -1 cytoplasm C00462 CHEBI:16042 based on metnx -R-S-glutathione [cytoplasm] C10H16N3O6SR 0 cytoplasm C02320 CHEBI:17021 based on kegg -L-Methionine S-oxide [cytoplasm] C5H11NO3S 0 cytoplasm C02989 CHEBI:17016 based on chebi -Ala-Gly [vacuole] C5H10N2O3 0 vacuole CHEBI:73757 based on chebi -L-alanine [vacuole] C3H7NO2 0 vacuole C00041 CHEBI:16977 based on chebi -L-glycine [vacuole] C2H5NO2 0 vacuole C00037 CHEBI:15428 based on chebi -Ala-Leu [vacuole] C9H18N2O3 0 vacuole CHEBI:73770 based on chebi -Threo-3-hydroxy-L-aspartate [cytoplasm] C4H6NO5 -1 cytoplasm C11511 CHEBI:57251 based on chebi -RX [peroxisome] RX 0 peroxisome C01322 CHEBI:17792 based on metnx -glutathione [peroxisome] C10H16N3O6S -1 peroxisome C00051 CHEBI:57925 Present in yeast model -HX [peroxisome] X -1 peroxisome C00462 CHEBI:16042 based on metnx -R-S-glutathione [peroxisome] C10H16N3O6SR 0 peroxisome C02320 CHEBI:17021 based on kegg -dehydroascorbate [cytoplasm] C6H6O6 0 cytoplasm C05422 CHEBI:27956 based on chebi -ascorbate [cytoplasm] C6H8O6 0 cytoplasm C00072 CHEBI:38290 based on metnx -dehydroascorbate [peroxisome] C6H6O6 0 peroxisome C05422 CHEBI:27956 based on chebi -glutathione disulfide [peroxisome] C20H30N6O12S2 -2 peroxisome C00127 CHEBI:58297 Present in yeast model -ascorbate [peroxisome] C6H8O6 0 peroxisome C00072 CHEBI:38290 based on metnx -Cyanamide [cytoplasm] CH2N2 0 cytoplasm C01566 CHEBI:16698 based on metnx -aldehydo-D-ribose 5-phosphate [cytoplasm] C5H9O8P -2 cytoplasm C00117 CHEBI:58273 based on chebi -R-S-Cysteinylglycine [cytoplasm] C5H9N2O3SR 0 cytoplasm C05729 CHEBI:8744 based on metnx -S-Substituted L-cysteine [cytoplasm] C3H6NO2SR 0 cytoplasm C05726 CHEBI:47910 based on chebi -iron(3+) [mitochondrion] Fe 3 mitochondrion C14819 CHEBI:29034 based on chebi -Glycyl-tRNA(Ala) [cytoplasm] 0 cytoplasm General type -D-tyrosyl-tRNA(Tyr) [cytoplasm] C9H10NO3R 0 cytoplasm General type -D-tyrosine [cytoplasm] C9H11NO3 0 cytoplasm C06420 CHEBI:28479 based on chebi -4-nitrophenyl phosphate [cytoplasm] C6H4NO6P -2 cytoplasm C03360 CHEBI:61146 based on chebi -4-nitrophenol [cytoplasm] C6H4NO3 -1 cytoplasm C00870 CHEBI:57917 based on chebi -L-iditol [cytoplasm] C6H14O6 0 cytoplasm C01507 CHEBI:18202 based on metnx -alpha-D-Galactose [cytoplasm] C6H12O6 0 cytoplasm C00984 CHEBI:28061 based on metnx -3-hydroxy-2-methylpropanoyl-CoA [mitochondrion] C25H38N7O18P3S -4 mitochondrion C04047 CHEBI:57340 based on chebi -3-hydroxy-2-methylpropanoate [mitochondrion] C4H7O3 -1 mitochondrion C01188 CHEBI:11805 based on metnx -sterols [extracellular] C19H31OR 0 extracellular C00370 CHEBI:15889 based on chebi -sterols [cytoplasm] C19H31OR 0 cytoplasm C00370 CHEBI:15889 based on chebi -2-Phenylacetamide [cytoplasm] C8H9NO 0 cytoplasm C02505 CHEBI:16562 based on metnx -(Indol-3-yl)acetamide [cytoplasm] C10H10N2O 0 cytoplasm C02693 CHEBI:16031 based on metnx -Monocarboxylic acid amide [cytoplasm] CH2NOR 0 cytoplasm C03620 based on kegg -Carboxylate [cytoplasm] CO2R -1 cytoplasm C00060 CHEBI:35757 based on chebi -Acrylic acid [cytoplasm] C3H3O2 -1 cytoplasm C00511 CHEBI:37080 based on metnx -Acrylamide [cytoplasm] C3H5NO 0 cytoplasm C01659 CHEBI:28619 based on metnx -Benzamide [cytoplasm] C7H7NO 0 cytoplasm C09815 CHEBI:28179 based on metnx -Benzoate [cytoplasm] C7H5O2 -1 cytoplasm C00180 CHEBI:16150 based on metnx -D-gluconate [cytoplasm] C6H11O7 -1 cytoplasm C00257 CHEBI:18391 based on metnx -Protein C-terminal S-farnesyl-L-cysteine [cytoplasm] C20H32N2O3SR -1 cytoplasm C04506 CHEBI:17171 based on kegg -Protein C-terminal S-farnesyl-L-cysteine methyl ester [cytoplasm] C21H35N2O3SR 0 cytoplasm C04748 CHEBI:15818 based on kegg -1-phosphatidyl-1D-myo-inositol [endoplasmic reticulum] C11H16O13PR2 -1 endoplasmic reticulum C01194 CHEBI:57880 Present in yeast model -G00143 [endoplasmic reticulum] C19H29NO18PR2 -1 endoplasmic reticulum CHEBI:57265 based on kegg and Rhea, G00143 -Ca(2+) [cytoplasm] Ca 2 cytoplasm C00076 CHEBI:29108 based on metnx -ATP [vacuole] C10H12N5O13P3 -4 vacuole C00002 CHEBI:30616 Present in yeast model -Ca(2+) [vacuole] Ca 2 vacuole C00076 CHEBI:29108 based on metnx -ADP [vacuole] C10H12N5O10P2 -3 vacuole C00008 CHEBI:456216 Present in yeast model -Protein [cytoplasm] C2H4NOR 1 cytoplasm C00017 General type -L-Arginyl-protein [cytoplasm] C8H17N5O2R 2 cytoplasm C16739 CHEBI:17518 based on kegg -Protein asparagine [endoplasmic reticulum] C4H6N2O2R 0 endoplasmic reticulum C03021 CHEBI:50347 based on chebi -G00008 [endoplasmic reticulum] C108H182N2O77P2R -2 endoplasmic reticulum based on kegg, G00008 -Dolichyl diphosphate [endoplasmic reticulum] C20H35O7P2R -3 endoplasmic reticulum CHEBI:57497 based on Rhea -G00009 [endoplasmic reticulum] C92H152N4O72R 0 endoplasmic reticulum CHEBI:132537 based on Rhea, G00009 -GDP-alpha-D-mannose [endoplasmic reticulum] C16H23N5O16P2 -2 endoplasmic reticulum C00096 CHEBI:57527 Present in yeast model -G10694 [endoplasmic reticulum] C68H112N4O52R 0 endoplasmic reticulum based on kegg and Rhea, G10694 -GDP [endoplasmic reticulum] C10H12N5O11P2 -3 endoplasmic reticulum C00035 CHEBI:58189 Present in yeast model -G01813 [endoplasmic reticulum] C74H122N4O57R 0 endoplasmic reticulum based on rxn, G01813 -G00003 [endoplasmic reticulum] C42H72N2O22P2R -2 endoplasmic reticulum based on metnx, MNXM1078, G00003 -G00004 [endoplasmic reticulum] C48H82N2O27P2R -2 endoplasmic reticulum based on metnx, MNXM11174, G00004 -G00005 [endoplasmic reticulum] C54H92N2O32P2R -2 endoplasmic reticulum based on metnx, MNXM162650, G00005 -2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate [vacuole] C9H14O12P -3 vacuole C16699 CHEBI:60331 based on metnx -D-Glycerate [cytoplasm] C3H5O4 -1 cytoplasm C00258 CHEBI:16659 based on metnx -alpha-D-mannoside [vacuole] C6H11O6R 0 vacuole C02603 CHEBI:27535 based on kegg -alpha-D-mannopyranose [vacuole] C6H12O6 0 vacuole C00936 CHEBI:28729 based on metnx -non glycosylated sugar acceptor [vacuole] HOR 0 vacuole General type -L-Threonylcarbamoyladenylate [cytoplasm] C15H19N6O11P -2 cytoplasm C20641 based on metnx, MNXM145767 -D-Serine [cytoplasm] C3H7NO3 0 cytoplasm C00740 CHEBI:16523 based on chebi -O-acetyl-L-serine [mitochondrion] C5H9NO4 0 mitochondrion C00979 CHEBI:17981 based on chebi -hydrogen sulfide [mitochondrion] HS -1 mitochondrion C00283 CHEBI:29919 Present in yeast model -beta-D-Fructose 6-phosphate [cytoplasm] C6H11O9P -2 cytoplasm C05345 CHEBI:57634 based on kegg -phosphatidate [mitochondrion] C5H7O8PR2 0 mitochondrion C00416 CHEBI:16337 based on chebi -CDP-diacylglycerol [mitochondrion] C14H17N3O15P2R2 -2 mitochondrion C00269 CHEBI:58332 based on chebi -Sulfur donor [cytoplasm] 0 cytoplasm C17023 CHEBI:80867 based on kegg -ADP-5-ethyl-4-methylthiazole-2-carboxylate [cytoplasm] C17H19N6O12P2S -3 cytoplasm C20784 CHEBI:134399 based on metnx, MNXM37826 -Dolichyl beta-D-glucosyl phosphate [endoplasmic reticulum] C26H46O9PR -1 endoplasmic reticulum C01246 CHEBI:57525 based on chebi -G10599 [endoplasmic reticulum] C102H172N2O72P2R -2 endoplasmic reticulum based on kegg, G10599 -nitric oxide [cytoplasm] NO 0 cytoplasm C00533 CHEBI:16480 based on metnx, MNXM228 -nitrate [cytoplasm] NO3 -1 cytoplasm C00244 CHEBI:17632 based on chebi -(R)-Lipoate [cytoplasm] C8H13O2S2 -1 cytoplasm C16241 CHEBI:83088 based on chebi -Lipoyl-AMP [cytoplasm] C18H25N5O8PS2 -1 cytoplasm C16238 CHEBI:83091 based on chebi -Apoprotein [cytoplasm] NH2R 0 cytoplasm C16240 CHEBI:13850 based on kegg -Protein N6-(lipoyl)lysine [cytoplasm] C8H14NOS2R 0 cytoplasm C16237 CHEBI:80399 based on metnx, MNXM96070 -N-(4-oxoglutarate)-L-cysteinylglycine [cytoplasm] C10H12N2O7S -2 cytoplasm CHEBI:138256 based on chebi -N-(4-oxoglutarate)-L-cysteinylglycine [mitochondrion] C10H12N2O7S -2 mitochondrion CHEBI:138256 based on chebi -L-cysteinylglycine [mitochondrion] C5H10N2O3S 0 mitochondrion C01419 CHEBI:4047 based on chebi -chloride [Golgi] Cl -1 Golgi C00698 CHEBI:17996 based on metnx -ribonucleoside 5'-triphosphate [cytoplasm] C5H8O13P3R -4 cytoplasm C03802 CHEBI:61557 based on metanetx MNXM96380 -ribonucleoside 5'-phosphate [cytoplasm] C5H8O7PR -2 cytoplasm CHEBI:58043 based on metanetx MNXM80910 -2'-deoxyribonucleoside 5'-triphosphate [cytoplasm] C5H8O12P3R -4 cytoplasm C00677 CHEBI:61560 based on metnx -2'-deoxyribonucleoside 5'-phosphate [cytoplasm] C5H8O6PR -2 cytoplasm C00676 CHEBI:65317 based on metnx -superoxide [cytoplasm] O2 -1 cytoplasm C00704 CHEBI:18421 based on metnx -G00012 [endoplasmic reticulum] C50H66N4O29 0 endoplasmic reticulum based on kegg, G00012 -D-mannose [endoplasmic reticulum] C6H12O6 0 endoplasmic reticulum C00159 CHEBI:4208 based on metnx -Ethylnitronate [cytoplasm] C2H5NO2 0 cytoplasm C18091 CHEBI:16268 based on chebi -Nitrite [cytoplasm] NO2 -1 cytoplasm C00088 CHEBI:16301 based on metnx -iron(3+) [extracellular] Fe 3 extracellular C14819 General type -Acyl-CoA [endoplasmic reticulum] C22H31N7O17P3SR -4 endoplasmic reticulum C00040 CHEBI:58342 based on chebi -1-acyl-sn-glycerol 3-phosphate [endoplasmic reticulum] C4H6O7PR -2 endoplasmic reticulum C00681 CHEBI:57970 based on chebi -1,2-diacyl-sn-glycerol 3-phosphate [endoplasmic reticulum] C5H5O8PR2 -2 endoplasmic reticulum C00416 CHEBI:58608 based on chebi -Peptide diphthine [cytoplasm] C13H20N4O3R2 0 cytoplasm C01573 CHEBI:18054 based on metnx MNXM51194 -Peptide diphthamide [cytoplasm] C13H22N5O2R2 1 cytoplasm C02872 CHEBI:82696 based on metnx MNXM4769 -8-oxo-dGTP [peroxisome] C10H16N5O14P3 -4 peroxisome C19967 based on metnx, MNXM4425 -8-oxo-dGMP [peroxisome] C10H14N5O8P -2 peroxisome C19968 based on metnx, MNXM2497 -Apoprotein [mitochondrion] NH2R 0 mitochondrion C16240 CHEBI:13850 based on kegg -Protein N6-(octanoyl)lysine [mitochondrion] C8H16NOR 0 mitochondrion C16236 CHEBI:80398 based on metnx -Lipoyl-[acp] [mitochondrion] C8H13OS3R 0 mitochondrion C16239 CHEBI:80400 based on metnx -Protein N6-(lipoyl)lysine [mitochondrion] C8H14NOS2R 0 mitochondrion C16237 CHEBI:80399 based on metnx -beta-D-Glucose [cytoplasm] C6H12O6 0 cytoplasm C00221 CHEBI:15903 based on metnx -beta-D-Glucose 6-phosphate [cytoplasm] C6H11O9P -2 cytoplasm C01172 CHEBI:58247 based on chebi -alpha-D-Glucose [cytoplasm] C6H12O6 0 cytoplasm C00267 CHEBI:17925 based on metnx -alpha-D-Glucose 6-phosphate [cytoplasm] C6H11O9P -2 cytoplasm C00668 CHEBI:58225 based on chebi -D-Glucosamine [cytoplasm] C6H13NO5 0 cytoplasm C00329 CHEBI:47977 based on chebi -beta-D-Fructose [cytoplasm] C6H12O6 0 cytoplasm C02336 CHEBI:28645 based on metnx -2-Propynal [cytoplasm] C3H2O 0 cytoplasm C05985 CHEBI:27976 based on metnx -Propynoate [cytoplasm] C3HO2 -1 cytoplasm C00804 CHEBI:15364 based on metnx -D-Glucuronolactone [cytoplasm] C6H8O6 0 cytoplasm C02670 CHEBI:18268 based on metnx -D-Glucarate [cytoplasm] C6H8O8 -2 cytoplasm C00818 CHEBI:30612 based on metnx -4-Trimethylammoniobutanal [cytoplasm] C7H16NO 1 cytoplasm C01149 CHEBI:18020 based on metnx -4-Trimethylammoniobutanoate [cytoplasm] C7H16NO2 1 cytoplasm C01181 CHEBI:1941 based on chebi -(S)-Methylmalonate semialdehyde [cytoplasm] C4H5O3 -1 cytoplasm C06002 CHEBI:62413 based on chebi -Methylmalonate [cytoplasm] C4H4O4 -2 cytoplasm C02170 CHEBI:17453 based on metnx -Imidazole-4-acetaldehyde [cytoplasm] C5H6N2O 0 cytoplasm C05130 CHEBI:27398 based on metnx -Imidazole-4-acetate [cytoplasm] C5H6N2O2 0 cytoplasm C02835 CHEBI:16974 based on chebi -3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al [cytoplasm] C27H46O3 0 cytoplasm C05445 CHEBI:27428 based on metnx -3alpha,7alpha-Dihydroxy-5beta-cholestanate [cytoplasm] C27H45O4 -1 cytoplasm C04554 CHEBI:16577 based on metnx -5-Hydroxyindoleacetaldehyde [cytoplasm] C10H9NO2 0 cytoplasm C05634 CHEBI:50157 based on metnx -5-Hydroxyindoleacetate [cytoplasm] C10H9NO3 0 cytoplasm C05635 CHEBI:27823 based on chebi -N4-Acetylaminobutanal [cytoplasm] C6H11NO2 0 cytoplasm C05936 CHEBI:7386 based on metnx -4-Acetamidobutanoate [cytoplasm] C6H10NO3 -1 cytoplasm C02946 CHEBI:11951 based on metnx -trans-3-Chloroallyl aldehyde [cytoplasm] C3H3ClO 0 cytoplasm C06613 CHEBI:28452 based on metnx -trans-3-Chloroacrylic acid [cytoplasm] C3H2ClO2 -1 cytoplasm C06614 CHEBI:19982 based on metnx -cis-3-Chloroallyl aldehyde [cytoplasm] C3H3ClO 0 cytoplasm C16348 CHEBI:80465 based on metnx -cis-3-Chloroacrylic acid [cytoplasm] C3H2ClO2 -1 cytoplasm C06615 CHEBI:27397 based on metnx -Chloroacetaldehyde [cytoplasm] C2H3ClO 0 cytoplasm C06754 CHEBI:27871 based on metnx -Chloroacetic acid [cytoplasm] C2H3ClO2 0 cytoplasm C06755 CHEBI:27869 based on chebi -Perillyl aldehyde [cytoplasm] C10H14O 0 cytoplasm C02576 CHEBI:15421 based on metnx -Perillic acid [cytoplasm] C10H14O2 0 cytoplasm C11924 CHEBI:36999 based on chebi -2-trans,6-trans-Farnesal [cytoplasm] C15H24O 0 cytoplasm C03461 CHEBI:15894 based on metnx -Farnesoic acid [cytoplasm] C15H24O2 0 cytoplasm C16502 CHEBI:84162 based on chebi -phospholipid [endoplasmic reticulum membrane] C5H6O8PR3 0 endoplasmic reticulum membrane C00865 CHEBI:16247 based on kegg -phospholipid [Golgi membrane] C5H6O8PR3 0 Golgi membrane C00865 CHEBI:16247 based on kegg -ADP [endoplasmic reticulum membrane] C10H12N5O10P2 -3 endoplasmic reticulum membrane C00008 CHEBI:456216 Present in yeast model -1-oleoyl-sn-glycerol [cytoplasm] C21H40O4 0 cytoplasm CHEBI:75757 based on chebi -G10526 [endoplasmic reticulum] C66H112N2O42P2R -2 endoplasmic reticulum CHEBI:132511 based on kegg and Rhea, G10526 -G00006 [endoplasmic reticulum] C78H132N2O52P2R -2 endoplasmic reticulum CHEBI:132515 based on kegg and Rhea, G00006 -carnosine [cytoplasm] C9H14N4O3 0 cytoplasm C00386 CHEBI:15727 based on chebi -anserine [cytoplasm] C10H16N4O3 0 cytoplasm C01262 CHEBI:18323 based on chebi -G10595 [endoplasmic reticulum] C72H122N2O47P2R -2 endoplasmic reticulum based on kegg, G10595 -G10596 [endoplasmic reticulum] C78H132N2O52P2R -2 endoplasmic reticulum based on kegg, G10596 -G10597 [endoplasmic reticulum] C84H142N2O57P2R -2 endoplasmic reticulum based on kegg, G10597 -G00007 [endoplasmic reticulum] C90H152N2O62P2R -2 endoplasmic reticulum based on kegg, G00007 -glycolate [cytoplasm] C2H3O3 -1 cytoplasm C00160 CHEBI:29805 based on metnx -sucrose [cytoplasm] C12H22O11 0 cytoplasm C00089 CHEBI:17992 based on metnx -Isomaltose [cytoplasm] C12H22O11 0 cytoplasm C00252 CHEBI:28189 based on metnx -Dextrin [cytoplasm] C12H20O10 0 cytoplasm C00721 CHEBI:28675 based on kegg -G10598 [endoplasmic reticulum] C96H162N2O67P2R 0 endoplasmic reticulum based on kegg and Rhea, G10598 -G00149 [endoplasmic reticulum] 0 endoplasmic reticulum based on kegg and Rhea, G00149 -G00140 [endoplasmic reticulum] 0 endoplasmic reticulum based on kegg and Rhea, G00140 -Sulfur donor [mitochondrion] 0 mitochondrion C17023 CHEBI:80867 based on kegg -5'-Deoxyadenosine [mitochondrion] C10H13N5O3 0 mitochondrion C05198 CHEBI:17319 based on metnx -S-sulfanyl-[L-cysteine desulfurase] [mitochondrion] 0 mitochondrion General type -[disordered-form [Fe-S] cluster scaffold protein] [mitochondrion] 0 mitochondrion -S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex [mitochondrion] 0 mitochondrion General type -hydrogen cyanide [mitochondrion] CHN 0 mitochondrion C01326 CHEBI:18407 based on metnx -thiosulfate [mitochondrion] HO3S2 -1 mitochondrion C00320 CHEBI:33541 based on chebi -sulphite [mitochondrion] O3S -2 mitochondrion C11481 CHEBI:17359 based on chebi -thiocyanate [mitochondrion] CHNS 0 mitochondrion C01755 CHEBI:29200 based on chebi -Mg(2+) [cytoplasm] Mg 2 cytoplasm C00305 CHEBI:18420 based on metnx -Mg(2+) [mitochondrion] Mg 2 mitochondrion C00305 CHEBI:18420 based on metnx -UDP-D-glucose [endoplasmic reticulum] C15H22N2O17P2 -2 endoplasmic reticulum C00029 CHEBI:58367 Present in yeast model -sulphate [endoplasmic reticulum] O4S -2 endoplasmic reticulum C00059 CHEBI:16189 based on metnx -N-Acetyl-D-glucosamine [cytoplasm] C8H15NO6 0 cytoplasm C00140 CHEBI:506227 based on metnx -polyphosphate [cytoplasm] HO7P2 -3 cytoplasm C00404 CHEBI:16838 based on chebi -Cu2(+) [cytoplasm] Cu 2 cytoplasm C00070 CHEBI:29036 based on chebi -Cu2(+) [Golgi] Cu 2 Golgi C00070 CHEBI:29036 based on chebi -2-Oxoglutaramate [cytoplasm] C5H6NO4 -1 cytoplasm C00940 CHEBI:16769 based on chebi -porphyrin [mitochondrion] C20H14N4 0 mitochondrion C05113 CHEBI:8337 based on metnx -porphyrin [cytoplasm] C20H14N4 0 cytoplasm C05113 CHEBI:8337 based on metnx -Starch [cytoplasm] C12H22O11 0 cytoplasm -D-mannose 6-phosphate [vacuole] C6H13O9P 0 vacuole C00275 CHEBI:17369 present in yeast model -D-Glycerate [vacuole] C3H5O4 -1 vacuole C00258 CHEBI:16659 based on metnx -Zn(2+) [mitochondrion] Zn 2 mitochondrion C00038 CHEBI:29105 based on metnx -Zn(2+) [vacuole] Zn 2 vacuole C00038 CHEBI:29105 based on metnx -RX [mitochondrion] RX 0 mitochondrion C01322 CHEBI:17792 based on metnx -HX [mitochondrion] X -1 mitochondrion C00462 CHEBI:16042 based on metnx -R-S-glutathione [mitochondrion] C10H16N3O6SR 0 mitochondrion C02320 CHEBI:17021 based on kegg -iron(3+) [vacuole] Fe 3 vacuole C14819 CHEBI:29034 based on chebi -UDP-N-acetyl-alpha-D-glucosamine [Golgi] C17H25N3O17P2 -2 Golgi C00043 CHEBI:57705 Present in yeast model -L-methionine [vacuole] C5H11NO2S 0 vacuole C00073 CHEBI:16643 Present in yeast model -ATP [Golgi] C10H12N5O13P3 -4 vacuole C00002 CHEBI:30616 Present in yeast model -Ca(2+) [Golgi] Ca 2 vacuole C00076 CHEBI:29108 based on metnx -ADP [Golgi] C10H12N5O10P2 -3 vacuole C00008 CHEBI:456216 Present in yeast model +NewMetName Charged formula Charge compartment KEGG ID CHEBI ID Remark +Cytochrome c [mitochondrion] C40H40FeN6O6S2 -2 mitochondrion C00524 CHEBI:83739 based on Rhea +Apocytochrome c [mitochondrion] C6H10N2O2S2 0 mitochondrion C02248 CHEBI:15697 based on Rhea +diacetyl [cytoplasm] C4H6O2 0 cytoplasm C00741 CHEBI:16583 based on metnx +(R)-acetoin [nucleus] C4H8O2 0 nucleus C00810 CHEBI:15686 based on metnx +diacetyl [nucleus] C4H6O2 0 nucleus C00741 CHEBI:16583 based on metnx +NADH [nucleus] C21H27N7O14P2 -2 nucleus C00004 CHEBI:57945 Present in yeast model +L-glutamyl-tRNA(Gln) [mitochondrion] C20H28N6O13PR 0 mitochondrion C06112 CHEBI:29165 based on kegg +L-glutamine [mitochondrion] C5H10N2O3 0 mitochondrion C00064 CHEBI:18050 based on chebi +Gln-tRNA(Gln) [mitochondrion] C20H29N7O12PR 0 mitochondrion C02282 CHEBI:29166 based on kegg +Met-Ala [vacuole] C8H16N2O3S 0 vacuole CHEBI:73610 based on chebi +ADP-D-ribose 1''-phosphate [cytoplasm] C15H20N5O17P3 -4 cytoplasm CHEBI:58753 based on chebi +ADP-ribose [cytoplasm] C15H21N5O14P2 -2 cytoplasm C00301 CHEBI:57967 Present in yeast model +quinone [cytoplasm] C6H4O2 0 cytoplasm C00472 CHEBI:16509 based on chebi +1,4-benzosemiquinone [cytoplasm] C6H5O2 0 cytoplasm CHEBI:17977 based on chebi +UDP-N-acetyl-alpha-D-glucosamine [endoplasmic reticulum] C17H25N3O17P2 -2 endoplasmic reticulum C00043 CHEBI:57705 Present in yeast model +N-Acetyl-D-glucosaminyldiphosphodolichol [endoplasmic reticulum] C28H51NO12P2R 0 endoplasmic reticulum C04500 CHEBI:18278 based on chebi +UDP [endoplasmic reticulum] C9H11N2O12P2 -3 endoplasmic reticulum C00015 CHEBI:58223 Present in yeast model +N,N'-Chitobiosyldiphosphodolichol [endoplasmic reticulum] C36H64N2O17P2R 0 endoplasmic reticulum based on kegg, G00002 +D-ribofuranose 5-phosphate [cytoplasm] C5H9O8P -2 cytoplasm CHEBI:78346 based on chebi +Oxalate [peroxisome] C2O4 -2 peroxisome C00209 CHEBI:30623 based on metnx +Oxalyl-CoA [peroxisome] C23H31N7O19P3S -5 peroxisome C00313 CHEBI:57388 based on chebi +G00171 [endoplasmic reticulum] C86H142N4O67R 0 endoplasmic reticulum based on kegg, G00171 +D-glucose [endoplasmic reticulum] C6H12O6 0 endoplasmic reticulum C00031 CHEBI:4167 based on metnx +G00010 [endoplasmic reticulum] C80H132N4O62R 0 endoplasmic reticulum based on kegg, G00010 +G00011 [endoplasmic reticulum] C74H122N4O57R 0 endoplasmic reticulum based on kegg, G00011 +sodium [vacuole] Na 1 vacuole C01330 CHEBI:29101 based on metnx +potassium [vacuole] K 1 vacuole C00238 CHEBI:29103 based on metnx +chloride [vacuole] Cl -1 vacuole C00698 CHEBI:17996 based on metnx +chloride [cytoplasm] Cl -1 cytoplasm C00698 CHEBI:17996 based on metnx +D-fructose [vacuole] C6H12O6 0 vacuole C00095 CHEBI:15824 based on chebi +D-galactose [vacuole] C6H12O6 0 vacuole C00124 CHEBI:4139 based on chebi +UMP [endoplasmic reticulum] C9H11N2O9P -2 endoplasmic reticulum C00105 CHEBI:57865 Present in yeast model +cadmium(2+) [cytoplasm] Cd 2 cytoplasm CHEBI:48775 based on chebi +cadmium(2+) [extracellular] Cd 2 extracellular CHEBI:48775 based on chebi +(sulfur carrier)-H [mitochondrion] R 0 mitochondrion General type +L-cysteine [mitochondrion] C3H7NO2S 0 mitochondrion C00097 CHEBI:17561 based on chebi +(sulfur carrier)-SH [mitochondrion] SR 0 mitochondrion General type +cholesterol [endoplasmic reticulum] C27H46O 0 endoplasmic reticulum C00187 CHEBI:16113 based on metnx +cholesterol [endoplasmic reticulum membrane] C27H46O 0 endoplasmic reticulum membrane C00187 CHEBI:16113 based on metnx +3-chlorobenzyl alcohol [cytoplasm] C7H7ClO 0 cytoplasm PubChem CID, 70117 +3-chlorobenzaldehyde [cytoplasm] C7H5ClO 0 cytoplasm PubChem CID, 70117 +3-hydroxybenzyl alcohol [cytoplasm] C7H8O2 0 cytoplasm C03351 CHEBI:17069 based on metnx +3-hydroxybenzaldehyde [cytoplasm] C7H6O2 0 cytoplasm C03067 CHEBI:16207 based on metnx +3-methylbenzyl alcohol [cytoplasm] C8H10O 0 cytoplasm C07216 CHEBI:27995 based on metnx +3-methylbenzaldehyde [cytoplasm] C8H8O 0 cytoplasm C07209 CHEBI:28476 based on metnx +4-isopropylbenzyl alcohol [cytoplasm] C10H14O 0 cytoplasm CHEBI:27628 based on chebi +p-cumic aldehyde [cytoplasm] C10H12O 0 cytoplasm C06577 CHEBI:28671 based on metnx +4-methylbenzyl alcohol [cytoplasm] C8H10O 0 cytoplasm C06757 CHEBI:1895 based on metnx +4-methylbenzaldehyde [cytoplasm] C8H8O 0 cytoplasm C06758 CHEBI:28617 based on metnx +benzyl alcohol [cytoplasm] C7H8O 0 cytoplasm C00556 CHEBI:17987 based on metnx +benzaldehyde [cytoplasm] C7H6O 0 cytoplasm C00261 CHEBI:17169 based on metnx +Mn(2+) [cytoplasm] Mn 2 cytoplasm C19610 CHEBI:29035 based on chebi +Mn(2+) [endoplasmic reticulum] Mn 2 endoplasmic reticulum C19610 CHEBI:29035 based on chebi +[protein]-L-lysine [cytoplasm] C6H13N2O 1 cytoplasm C02188 CHEBI:29969 based on Rhea and chebi +[protein]-N(6)-acetyl-L-lysine [cytoplasm] C8H14N2O2 0 cytoplasm CHEBI:61930 based on Rhea +Mannitol [cytoplasm] C6H14O6 0 cytoplasm C00392 CHEBI:16899 based on metnx +4-hydroxy-4-methyl-2-oxoglutarate [cytoplasm] C6H6O6 -2 cytoplasm C06033 CHEBI:58276 based on chebi and Rhea +L-methionine (S)-S-oxide [cytoplasm] C5H11NO3S 0 cytoplasm C15999 CHEBI:49031 based on chebi +tRNA(Pro) [mitochondrion] R -1 mitochondrion C01649 CHEBI:29177 Present in yeast model +Pro-tRNA(Pro) [mitochondrion] C5H8NOR 0 mitochondrion C02702 CHEBI:29154 Present in yeast model +5-oxo-L-proline [cytoplasm] C5H6NO3 -1 cytoplasm C01879 CHEBI:58402 based on chebi +4a-Hydroxytetrahydrobiopterin [mitochondrion] C9H15N5O4 0 mitochondrion C15522 CHEBI:15642 based on metnx +Dihydrobiopterin [mitochondrion] C9H13N5O3 0 mitochondrion C00268 CHEBI:20680 based on metnx +superoxide [mitochondrion] O2 -1 mitochondrion C00704 CHEBI:18421 based on metnx +2-deoxy-D-glucose 6-phosphate [cytoplasm] C6H11O8P -2 cytoplasm C06369 CHEBI:84760 based on chebi +2-deoxy-D-glucose [cytoplasm] C6H12O5 0 cytoplasm C00586 CHEBI:84755 based on chebi +[cytochrome c]-L-lysine [cytoplasm] C6H13N2O 1 cytoplasm CHEBI:29969 based on kegg and Rhea +[cytochrome c]-N6-methyl-L-lysine [cytoplasm] C7H15N2O 1 cytoplasm CHEBI:61929 based on kegg and Rhea +S-adenosyl-L-methionine [nucleus] C15H23N6O5S 1 nucleus C00019 CHEBI:67040 Present in yeast model +L-lysine-[histone] [nucleus] C6H13N2OR2 1 nucleus CHEBI:29969 General type, based on metanetx MNXM59465 +S-adenosyl-L-homocysteine [nucleus] C14H20N6O5S 0 nucleus C00021 CHEBI:16680 based on chebi +N6-methyl-L-lysine-[histone] [nucleus] C7H15N2OR2 1 nucleus CHEBI:61929 General type, Histone N6-methyl-L-lysine, C03702, based on metanetx MNXM63025 +Zn(2+) [cytoplasm] Zn 2 cytoplasm C00038 CHEBI:29105 based on metnx +Zn(2+) [endoplasmic reticulum] Zn 2 endoplasmic reticulum C00038 CHEBI:29105 based on metnx +Ferricytochrome b5 [endoplasmic reticulum] Fe 3 endoplasmic reticulum C00996 CHEBI:18097 based on kegg and Rhea +Ferrocytochrome b5 [endoplasmic reticulum] Fe 2 endoplasmic reticulum C00999 based on kegg and Rhea +Ferricytochrome b5 [mitochondrion] Fe 3 mitochondrion C00996 CHEBI:18097 based on kegg and Rhea +Ferrocytochrome b5 [mitochondrion] Fe 2 mitochondrion C00999 based on kegg and Rhea +(S)-benzoin [cytoplasm] C14H12O2 0 cytoplasm C20227 based on kegg and Rhea +benzil [cytoplasm] C14H10O2 0 cytoplasm C20226 CHEBI:51507 based on metnx +RX [endoplasmic reticulum] RX 0 endoplasmic reticulum C01322 CHEBI:17792 based on metnx +glutathione [endoplasmic reticulum] C10H16N3O6S -1 endoplasmic reticulum C00051 CHEBI:57925 Present in yeast model +HX [endoplasmic reticulum] X -1 endoplasmic reticulum C00462 CHEBI:16042 based on metnx +R-S-glutathione [endoplasmic reticulum] C10H16N3O6SR 0 endoplasmic reticulum C02320 CHEBI:17021 based on kegg +RX [cytoplasm] RX 0 cytoplasm C01322 CHEBI:17792 based on metnx +HX [cytoplasm] X -1 cytoplasm C00462 CHEBI:16042 based on metnx +R-S-glutathione [cytoplasm] C10H16N3O6SR 0 cytoplasm C02320 CHEBI:17021 based on kegg +L-Methionine S-oxide [cytoplasm] C5H11NO3S 0 cytoplasm C02989 CHEBI:17016 based on chebi +Ala-Gly [vacuole] C5H10N2O3 0 vacuole CHEBI:73757 based on chebi +L-alanine [vacuole] C3H7NO2 0 vacuole C00041 CHEBI:16977 based on chebi +L-glycine [vacuole] C2H5NO2 0 vacuole C00037 CHEBI:15428 based on chebi +Ala-Leu [vacuole] C9H18N2O3 0 vacuole CHEBI:73770 based on chebi +Threo-3-hydroxy-L-aspartate [cytoplasm] C4H6NO5 -1 cytoplasm C11511 CHEBI:57251 based on chebi +RX [peroxisome] RX 0 peroxisome C01322 CHEBI:17792 based on metnx +glutathione [peroxisome] C10H16N3O6S -1 peroxisome C00051 CHEBI:57925 Present in yeast model +HX [peroxisome] X -1 peroxisome C00462 CHEBI:16042 based on metnx +R-S-glutathione [peroxisome] C10H16N3O6SR 0 peroxisome C02320 CHEBI:17021 based on kegg +dehydroascorbate [cytoplasm] C6H6O6 0 cytoplasm C05422 CHEBI:27956 based on chebi +ascorbate [cytoplasm] C6H8O6 0 cytoplasm C00072 CHEBI:38290 based on metnx +dehydroascorbate [peroxisome] C6H6O6 0 peroxisome C05422 CHEBI:27956 based on chebi +glutathione disulfide [peroxisome] C20H30N6O12S2 -2 peroxisome C00127 CHEBI:58297 Present in yeast model +ascorbate [peroxisome] C6H8O6 0 peroxisome C00072 CHEBI:38290 based on metnx +Cyanamide [cytoplasm] CH2N2 0 cytoplasm C01566 CHEBI:16698 based on metnx +aldehydo-D-ribose 5-phosphate [cytoplasm] C5H9O8P -2 cytoplasm C00117 CHEBI:58273 based on chebi +R-S-Cysteinylglycine [cytoplasm] C5H9N2O3SR 0 cytoplasm C05729 CHEBI:8744 based on metnx +S-Substituted L-cysteine [cytoplasm] C3H6NO2SR 0 cytoplasm C05726 CHEBI:47910 based on chebi +iron(3+) [mitochondrion] Fe 3 mitochondrion C14819 CHEBI:29034 based on chebi +Glycyl-tRNA(Ala) [cytoplasm] 0 cytoplasm General type +D-tyrosyl-tRNA(Tyr) [cytoplasm] C9H10NO3R 0 cytoplasm General type +D-tyrosine [cytoplasm] C9H11NO3 0 cytoplasm C06420 CHEBI:28479 based on chebi +4-nitrophenyl phosphate [cytoplasm] C6H4NO6P -2 cytoplasm C03360 CHEBI:61146 based on chebi +4-nitrophenol [cytoplasm] C6H4NO3 -1 cytoplasm C00870 CHEBI:57917 based on chebi +L-iditol [cytoplasm] C6H14O6 0 cytoplasm C01507 CHEBI:18202 based on metnx +alpha-D-Galactose [cytoplasm] C6H12O6 0 cytoplasm C00984 CHEBI:28061 based on metnx +3-hydroxy-2-methylpropanoyl-CoA [mitochondrion] C25H38N7O18P3S -4 mitochondrion C04047 CHEBI:57340 based on chebi +3-hydroxy-2-methylpropanoate [mitochondrion] C4H7O3 -1 mitochondrion C01188 CHEBI:11805 based on metnx +sterols [extracellular] C19H31OR 0 extracellular C00370 CHEBI:15889 based on chebi +sterols [cytoplasm] C19H31OR 0 cytoplasm C00370 CHEBI:15889 based on chebi +2-Phenylacetamide [cytoplasm] C8H9NO 0 cytoplasm C02505 CHEBI:16562 based on metnx +(Indol-3-yl)acetamide [cytoplasm] C10H10N2O 0 cytoplasm C02693 CHEBI:16031 based on metnx +Monocarboxylic acid amide [cytoplasm] CH2NOR 0 cytoplasm C03620 based on kegg +Carboxylate [cytoplasm] CO2R -1 cytoplasm C00060 CHEBI:35757 based on chebi +Acrylic acid [cytoplasm] C3H3O2 -1 cytoplasm C00511 CHEBI:37080 based on metnx +Acrylamide [cytoplasm] C3H5NO 0 cytoplasm C01659 CHEBI:28619 based on metnx +Benzamide [cytoplasm] C7H7NO 0 cytoplasm C09815 CHEBI:28179 based on metnx +Benzoate [cytoplasm] C7H5O2 -1 cytoplasm C00180 CHEBI:16150 based on metnx +D-gluconate [cytoplasm] C6H11O7 -1 cytoplasm C00257 CHEBI:18391 based on metnx +Protein C-terminal S-farnesyl-L-cysteine [cytoplasm] C20H32N2O3SR -1 cytoplasm C04506 CHEBI:17171 based on kegg +Protein C-terminal S-farnesyl-L-cysteine methyl ester [cytoplasm] C21H35N2O3SR 0 cytoplasm C04748 CHEBI:15818 based on kegg +1-phosphatidyl-1D-myo-inositol [endoplasmic reticulum] C11H16O13PR2 -1 endoplasmic reticulum C01194 CHEBI:57880 Present in yeast model +G00143 [endoplasmic reticulum] C19H29NO18PR2 -1 endoplasmic reticulum CHEBI:57265 based on kegg and Rhea, G00143 +Ca(2+) [cytoplasm] Ca 2 cytoplasm C00076 CHEBI:29108 based on metnx +ATP [vacuole] C10H12N5O13P3 -4 vacuole C00002 CHEBI:30616 Present in yeast model +Ca(2+) [vacuole] Ca 2 vacuole C00076 CHEBI:29108 based on metnx +ADP [vacuole] C10H12N5O10P2 -3 vacuole C00008 CHEBI:456216 Present in yeast model +Protein [cytoplasm] C2H4NOR 1 cytoplasm C00017 General type +L-Arginyl-protein [cytoplasm] C8H17N5O2R 2 cytoplasm C16739 CHEBI:17518 based on kegg +Protein asparagine [endoplasmic reticulum] C4H6N2O2R 0 endoplasmic reticulum C03021 CHEBI:50347 based on chebi +G00008 [endoplasmic reticulum] C108H182N2O77P2R -2 endoplasmic reticulum based on kegg, G00008 +Dolichyl diphosphate [endoplasmic reticulum] C20H35O7P2R -3 endoplasmic reticulum CHEBI:57497 based on Rhea +G00009 [endoplasmic reticulum] C92H152N4O72R 0 endoplasmic reticulum CHEBI:132537 based on Rhea, G00009 +GDP-alpha-D-mannose [endoplasmic reticulum] C16H23N5O16P2 -2 endoplasmic reticulum C00096 CHEBI:57527 Present in yeast model +G10694 [endoplasmic reticulum] C68H112N4O52R 0 endoplasmic reticulum based on kegg and Rhea, G10694 +GDP [endoplasmic reticulum] C10H12N5O11P2 -3 endoplasmic reticulum C00035 CHEBI:58189 Present in yeast model +G01813 [endoplasmic reticulum] C74H122N4O57R 0 endoplasmic reticulum based on rxn, G01813 +G00003 [endoplasmic reticulum] C42H72N2O22P2R -2 endoplasmic reticulum based on metnx, MNXM1078, G00003 +G00004 [endoplasmic reticulum] C48H82N2O27P2R -2 endoplasmic reticulum based on metnx, MNXM11174, G00004 +G00005 [endoplasmic reticulum] C54H92N2O32P2R -2 endoplasmic reticulum based on metnx, MNXM162650, G00005 +2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate [vacuole] C9H14O12P -3 vacuole C16699 CHEBI:60331 based on metnx +D-Glycerate [cytoplasm] C3H5O4 -1 cytoplasm C00258 CHEBI:16659 based on metnx +alpha-D-mannoside [vacuole] C6H11O6R 0 vacuole C02603 CHEBI:27535 based on kegg +alpha-D-mannopyranose [vacuole] C6H12O6 0 vacuole C00936 CHEBI:28729 based on metnx +non glycosylated sugar acceptor [vacuole] HOR 0 vacuole General type +L-Threonylcarbamoyladenylate [cytoplasm] C15H19N6O11P -2 cytoplasm C20641 based on metnx, MNXM145767 +D-Serine [cytoplasm] C3H7NO3 0 cytoplasm C00740 CHEBI:16523 based on chebi +O-acetyl-L-serine [mitochondrion] C5H9NO4 0 mitochondrion C00979 CHEBI:17981 based on chebi +hydrogen sulfide [mitochondrion] HS -1 mitochondrion C00283 CHEBI:29919 Present in yeast model +beta-D-Fructose 6-phosphate [cytoplasm] C6H11O9P -2 cytoplasm C05345 CHEBI:57634 based on kegg +phosphatidate [mitochondrion] C5H7O8PR2 0 mitochondrion C00416 CHEBI:16337 based on chebi +CDP-diacylglycerol [mitochondrion] C14H17N3O15P2R2 -2 mitochondrion C00269 CHEBI:58332 based on chebi +Sulfur donor [cytoplasm] 0 cytoplasm C17023 CHEBI:80867 based on kegg +ADP-5-ethyl-4-methylthiazole-2-carboxylate [cytoplasm] C17H19N6O12P2S -3 cytoplasm C20784 CHEBI:134399 based on metnx, MNXM37826 +Dolichyl beta-D-glucosyl phosphate [endoplasmic reticulum] C26H46O9PR -1 endoplasmic reticulum C01246 CHEBI:57525 based on chebi +G10599 [endoplasmic reticulum] C102H172N2O72P2R -2 endoplasmic reticulum based on kegg, G10599 +nitric oxide [cytoplasm] NO 0 cytoplasm C00533 CHEBI:16480 based on metnx, MNXM228 +nitrate [cytoplasm] NO3 -1 cytoplasm C00244 CHEBI:17632 based on chebi +(R)-Lipoate [cytoplasm] C8H13O2S2 -1 cytoplasm C16241 CHEBI:83088 based on chebi +Lipoyl-AMP [cytoplasm] C18H25N5O8PS2 -1 cytoplasm C16238 CHEBI:83091 based on chebi +Apoprotein [cytoplasm] NH2R 0 cytoplasm C16240 CHEBI:13850 based on kegg +Protein N6-(lipoyl)lysine [cytoplasm] C8H14NOS2R 0 cytoplasm C16237 CHEBI:80399 based on metnx, MNXM96070 +N-(4-oxoglutarate)-L-cysteinylglycine [cytoplasm] C10H12N2O7S -2 cytoplasm CHEBI:138256 based on chebi +N-(4-oxoglutarate)-L-cysteinylglycine [mitochondrion] C10H12N2O7S -2 mitochondrion CHEBI:138256 based on chebi +L-cysteinylglycine [mitochondrion] C5H10N2O3S 0 mitochondrion C01419 CHEBI:4047 based on chebi +chloride [Golgi] Cl -1 Golgi C00698 CHEBI:17996 based on metnx +ribonucleoside 5'-triphosphate [cytoplasm] C5H8O13P3R -4 cytoplasm C03802 CHEBI:61557 based on metanetx MNXM96380 +ribonucleoside 5'-phosphate [cytoplasm] C5H8O7PR -2 cytoplasm CHEBI:58043 based on metanetx MNXM80910 +2'-deoxyribonucleoside 5'-triphosphate [cytoplasm] C5H8O12P3R -4 cytoplasm C00677 CHEBI:61560 based on metnx +2'-deoxyribonucleoside 5'-phosphate [cytoplasm] C5H8O6PR -2 cytoplasm C00676 CHEBI:65317 based on metnx +superoxide [cytoplasm] O2 -1 cytoplasm C00704 CHEBI:18421 based on metnx +G00012 [endoplasmic reticulum] C50H66N4O29 0 endoplasmic reticulum based on kegg, G00012 +D-mannose [endoplasmic reticulum] C6H12O6 0 endoplasmic reticulum C00159 CHEBI:4208 based on metnx +Ethylnitronate [cytoplasm] C2H5NO2 0 cytoplasm C18091 CHEBI:16268 based on chebi +Nitrite [cytoplasm] NO2 -1 cytoplasm C00088 CHEBI:16301 based on metnx +iron(3+) [extracellular] Fe 3 extracellular C14819 General type +Acyl-CoA [endoplasmic reticulum] C22H31N7O17P3SR -4 endoplasmic reticulum C00040 CHEBI:58342 based on chebi +1-acyl-sn-glycerol 3-phosphate [endoplasmic reticulum] C4H6O7PR -2 endoplasmic reticulum C00681 CHEBI:57970 based on chebi +1,2-diacyl-sn-glycerol 3-phosphate [endoplasmic reticulum] C5H5O8PR2 -2 endoplasmic reticulum C00416 CHEBI:58608 based on chebi +Peptide diphthine [cytoplasm] C13H20N4O3R2 0 cytoplasm C01573 CHEBI:18054 based on metnx MNXM51194 +Peptide diphthamide [cytoplasm] C13H22N5O2R2 1 cytoplasm C02872 CHEBI:82696 based on metnx MNXM4769 +8-oxo-dGTP [peroxisome] C10H16N5O14P3 -4 peroxisome C19967 based on metnx, MNXM4425 +8-oxo-dGMP [peroxisome] C10H14N5O8P -2 peroxisome C19968 based on metnx, MNXM2497 +Apoprotein [mitochondrion] NH2R 0 mitochondrion C16240 CHEBI:13850 based on kegg +Protein N6-(octanoyl)lysine [mitochondrion] C8H16NOR 0 mitochondrion C16236 CHEBI:80398 based on metnx +Lipoyl-[acp] [mitochondrion] C8H13OS3R 0 mitochondrion C16239 CHEBI:80400 based on metnx +Protein N6-(lipoyl)lysine [mitochondrion] C8H14NOS2R 0 mitochondrion C16237 CHEBI:80399 based on metnx +beta-D-Glucose [cytoplasm] C6H12O6 0 cytoplasm C00221 CHEBI:15903 based on metnx +beta-D-Glucose 6-phosphate [cytoplasm] C6H11O9P -2 cytoplasm C01172 CHEBI:58247 based on chebi +alpha-D-Glucose [cytoplasm] C6H12O6 0 cytoplasm C00267 CHEBI:17925 based on metnx +alpha-D-Glucose 6-phosphate [cytoplasm] C6H11O9P -2 cytoplasm C00668 CHEBI:58225 based on chebi +D-Glucosamine [cytoplasm] C6H13NO5 0 cytoplasm C00329 CHEBI:47977 based on chebi +beta-D-Fructose [cytoplasm] C6H12O6 0 cytoplasm C02336 CHEBI:28645 based on metnx +2-Propynal [cytoplasm] C3H2O 0 cytoplasm C05985 CHEBI:27976 based on metnx +Propynoate [cytoplasm] C3HO2 -1 cytoplasm C00804 CHEBI:15364 based on metnx +D-Glucuronolactone [cytoplasm] C6H8O6 0 cytoplasm C02670 CHEBI:18268 based on metnx +D-Glucarate [cytoplasm] C6H8O8 -2 cytoplasm C00818 CHEBI:30612 based on metnx +4-Trimethylammoniobutanal [cytoplasm] C7H16NO 1 cytoplasm C01149 CHEBI:18020 based on metnx +4-Trimethylammoniobutanoate [cytoplasm] C7H16NO2 1 cytoplasm C01181 CHEBI:1941 based on chebi +(S)-Methylmalonate semialdehyde [cytoplasm] C4H5O3 -1 cytoplasm C06002 CHEBI:62413 based on chebi +Methylmalonate [cytoplasm] C4H4O4 -2 cytoplasm C02170 CHEBI:17453 based on metnx +Imidazole-4-acetaldehyde [cytoplasm] C5H6N2O 0 cytoplasm C05130 CHEBI:27398 based on metnx +Imidazole-4-acetate [cytoplasm] C5H6N2O2 0 cytoplasm C02835 CHEBI:16974 based on chebi +3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al [cytoplasm] C27H46O3 0 cytoplasm C05445 CHEBI:27428 based on metnx +3alpha,7alpha-Dihydroxy-5beta-cholestanate [cytoplasm] C27H45O4 -1 cytoplasm C04554 CHEBI:16577 based on metnx +5-Hydroxyindoleacetaldehyde [cytoplasm] C10H9NO2 0 cytoplasm C05634 CHEBI:50157 based on metnx +5-Hydroxyindoleacetate [cytoplasm] C10H9NO3 0 cytoplasm C05635 CHEBI:27823 based on chebi +N4-Acetylaminobutanal [cytoplasm] C6H11NO2 0 cytoplasm C05936 CHEBI:7386 based on metnx +4-Acetamidobutanoate [cytoplasm] C6H10NO3 -1 cytoplasm C02946 CHEBI:11951 based on metnx +trans-3-Chloroallyl aldehyde [cytoplasm] C3H3ClO 0 cytoplasm C06613 CHEBI:28452 based on metnx +trans-3-Chloroacrylic acid [cytoplasm] C3H2ClO2 -1 cytoplasm C06614 CHEBI:19982 based on metnx +cis-3-Chloroallyl aldehyde [cytoplasm] C3H3ClO 0 cytoplasm C16348 CHEBI:80465 based on metnx +cis-3-Chloroacrylic acid [cytoplasm] C3H2ClO2 -1 cytoplasm C06615 CHEBI:27397 based on metnx +Chloroacetaldehyde [cytoplasm] C2H3ClO 0 cytoplasm C06754 CHEBI:27871 based on metnx +Chloroacetic acid [cytoplasm] C2H3ClO2 0 cytoplasm C06755 CHEBI:27869 based on chebi +Perillyl aldehyde [cytoplasm] C10H14O 0 cytoplasm C02576 CHEBI:15421 based on metnx +Perillic acid [cytoplasm] C10H14O2 0 cytoplasm C11924 CHEBI:36999 based on chebi +2-trans,6-trans-Farnesal [cytoplasm] C15H24O 0 cytoplasm C03461 CHEBI:15894 based on metnx +Farnesoic acid [cytoplasm] C15H24O2 0 cytoplasm C16502 CHEBI:84162 based on chebi +phospholipid [endoplasmic reticulum membrane] C5H6O8PR3 0 endoplasmic reticulum membrane C00865 CHEBI:16247 based on kegg +phospholipid [Golgi membrane] C5H6O8PR3 0 Golgi membrane C00865 CHEBI:16247 based on kegg +ADP [endoplasmic reticulum membrane] C10H12N5O10P2 -3 endoplasmic reticulum membrane C00008 CHEBI:456216 Present in yeast model +1-oleoyl-sn-glycerol [cytoplasm] C21H40O4 0 cytoplasm CHEBI:75757 based on chebi +G10526 [endoplasmic reticulum] C66H112N2O42P2R -2 endoplasmic reticulum CHEBI:132511 based on kegg and Rhea, G10526 +G00006 [endoplasmic reticulum] C78H132N2O52P2R -2 endoplasmic reticulum CHEBI:132515 based on kegg and Rhea, G00006 +carnosine [cytoplasm] C9H14N4O3 0 cytoplasm C00386 CHEBI:15727 based on chebi +anserine [cytoplasm] C10H16N4O3 0 cytoplasm C01262 CHEBI:18323 based on chebi +G10595 [endoplasmic reticulum] C72H122N2O47P2R -2 endoplasmic reticulum based on kegg, G10595 +G10596 [endoplasmic reticulum] C78H132N2O52P2R -2 endoplasmic reticulum based on kegg, G10596 +G10597 [endoplasmic reticulum] C84H142N2O57P2R -2 endoplasmic reticulum based on kegg, G10597 +G00007 [endoplasmic reticulum] C90H152N2O62P2R -2 endoplasmic reticulum based on kegg, G00007 +glycolate [cytoplasm] C2H3O3 -1 cytoplasm C00160 CHEBI:29805 based on metnx +sucrose [cytoplasm] C12H22O11 0 cytoplasm C00089 CHEBI:17992 based on metnx +Isomaltose [cytoplasm] C12H22O11 0 cytoplasm C00252 CHEBI:28189 based on metnx +Dextrin [cytoplasm] C12H20O10 0 cytoplasm C00721 CHEBI:28675 based on kegg +G10598 [endoplasmic reticulum] C96H162N2O67P2R 0 endoplasmic reticulum based on kegg and Rhea, G10598 +G00149 [endoplasmic reticulum] 0 endoplasmic reticulum based on kegg and Rhea, G00149 +G00140 [endoplasmic reticulum] 0 endoplasmic reticulum based on kegg and Rhea, G00140 +Sulfur donor [mitochondrion] 0 mitochondrion C17023 CHEBI:80867 based on kegg +5'-Deoxyadenosine [mitochondrion] C10H13N5O3 0 mitochondrion C05198 CHEBI:17319 based on metnx +S-sulfanyl-[L-cysteine desulfurase] [mitochondrion] 0 mitochondrion General type +[disordered-form [Fe-S] cluster scaffold protein] [mitochondrion] 0 mitochondrion +S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex [mitochondrion] 0 mitochondrion General type +hydrogen cyanide [mitochondrion] CHN 0 mitochondrion C01326 CHEBI:18407 based on metnx +thiosulfate [mitochondrion] HO3S2 -1 mitochondrion C00320 CHEBI:33541 based on chebi +sulphite [mitochondrion] O3S -2 mitochondrion C11481 CHEBI:17359 based on chebi +thiocyanate [mitochondrion] CHNS 0 mitochondrion C01755 CHEBI:29200 based on chebi +Mg(2+) [cytoplasm] Mg 2 cytoplasm C00305 CHEBI:18420 based on metnx +Mg(2+) [mitochondrion] Mg 2 mitochondrion C00305 CHEBI:18420 based on metnx +UDP-D-glucose [endoplasmic reticulum] C15H22N2O17P2 -2 endoplasmic reticulum C00029 CHEBI:58367 Present in yeast model +sulphate [endoplasmic reticulum] O4S -2 endoplasmic reticulum C00059 CHEBI:16189 based on metnx +N-Acetyl-D-glucosamine [cytoplasm] C8H15NO6 0 cytoplasm C00140 CHEBI:506227 based on metnx +polyphosphate [cytoplasm] HO7P2 -3 cytoplasm C00404 CHEBI:16838 based on chebi +Cu2(+) [cytoplasm] Cu 2 cytoplasm C00070 CHEBI:29036 based on chebi +Cu2(+) [Golgi] Cu 2 Golgi C00070 CHEBI:29036 based on chebi +2-Oxoglutaramate [cytoplasm] C5H6NO4 -1 cytoplasm C00940 CHEBI:16769 based on chebi +porphyrin [mitochondrion] C20H14N4 0 mitochondrion C05113 CHEBI:8337 based on metnx +porphyrin [cytoplasm] C20H14N4 0 cytoplasm C05113 CHEBI:8337 based on metnx +Starch [cytoplasm] C12H22O11 0 cytoplasm +D-mannose 6-phosphate [vacuole] C6H13O9P 0 vacuole C00275 CHEBI:17369 present in yeast model +D-Glycerate [vacuole] C3H5O4 -1 vacuole C00258 CHEBI:16659 based on metnx +Zn(2+) [mitochondrion] Zn 2 mitochondrion C00038 CHEBI:29105 based on metnx +Zn(2+) [vacuole] Zn 2 vacuole C00038 CHEBI:29105 based on metnx +RX [mitochondrion] RX 0 mitochondrion C01322 CHEBI:17792 based on metnx +HX [mitochondrion] X -1 mitochondrion C00462 CHEBI:16042 based on metnx +R-S-glutathione [mitochondrion] C10H16N3O6SR 0 mitochondrion C02320 CHEBI:17021 based on kegg +iron(3+) [vacuole] Fe 3 vacuole C14819 CHEBI:29034 based on chebi +UDP-N-acetyl-alpha-D-glucosamine [Golgi] C17H25N3O17P2 -2 Golgi C00043 CHEBI:57705 Present in yeast model +L-methionine [vacuole] C5H11NO2S 0 vacuole C00073 CHEBI:16643 Present in yeast model +ATP [Golgi] C10H12N5O13P3 -4 vacuole C00002 CHEBI:30616 Present in yeast model +Ca(2+) [Golgi] Ca 2 vacuole C00076 CHEBI:29108 based on metnx +ADP [Golgi] C10H12N5O10P2 -3 vacuole C00008 CHEBI:456216 Present in yeast model diff --git a/ComplementaryData/modelCuration/DBnewRxnProp.tsv b/ComplementaryData/modelCuration/DBnewRxnProp.tsv index 5bb8bfbd..df45ccd2 100755 --- a/ComplementaryData/modelCuration/DBnewRxnProp.tsv +++ b/ComplementaryData/modelCuration/DBnewRxnProp.tsv @@ -1,184 +1,184 @@ -RxnID REV GPR RxnName EC Subsystems RxnKEGGid -R02480 1 ( YAL039C or YKL087C ) Cytochrome c apocytochrome-c-lyase 4.4.1.17;4.4.1.- sce00860 porphyrin and chlorophyll metabolism R02480 -R02855 1 YAL061W (R)-Acetoin:NAD+ oxidoreductase 1.1.1.303 sce00650 butanoate metabolism R02855 -R02855_2 1 YAL061W Probable diacetyl reductase [(R)-acetoin forming] 2 (EC 1.1.1.303) 1.1.1.303 sce00650 butanoate metabolism R02855 -6.3.5.6-RXN 0 YBL080C Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112) 6.3.5.- sce00970 aminoacyl-trna biosynthesis -MNXR100968 1 ( YBL091C or YLR244C ) Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M) 3.4.11.18 other -MNXR116282 1 ( YBR022W or YMR087W ) ADP-ribose 1''-phosphate phosphatase (EC 3.1.3.84) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase) 3.1.3.84; 3.2.2.- other -R02364 1 YBR046C NADPH2:quinone oxidoreductase 1.6.5.5 sce00350 tyrosine metabolism R02364 -R05970 1 ( YBR070C and YGL047W ) UDP-N-acetylglucosamine transferase subunit ALG14 (Asparagine-linked glycosylation protein 14) 2.4.1.141 sce00510 n-glycan biosynthesis R05970 -MNXR106807 1 YBR111C ADP-ribose pyrophosphatase (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) 3.6.1.13 sce00230 purine metabolism -MNXR95951 1 ( YBR147W or YDR352W ) Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) l-arg transport (from lysosomal lumen to cytosol);l-his transport (from lysosomal lumen to cytosol);l-lys transport (from lysoso... -MNXR100645 1 ( YBR147W or YDR352W ) Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) l-arg transport (from lysosomal lumen to cytosol);l-his transport (from lysosomal lumen to cytosol);l-lys transport (from lysoso... -MNXR101266 1 ( YBR147W or YDR352W ) Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) l-arg transport (from lysosomal lumen to cytosol);l-his transport (from lysosomal lumen to cytosol);l-lys transport (from lysoso... -R01558 1 YBR222C oxalate:CoA ligase (AMP-forming) 6.-.-.- sce00630 glyoxylate and dicarboxylate metabolism R01558 -R05980 1 YBR229C Glucosidase 2 subunit alpha (EC 3.2.1.84) (Alpha-glucosidase II subunit alpha) (Glucosidase II subunit alpha) (Reversal of TOR2 lethality protein 2) 3.2.1.84 sce00510 n-glycan biosynthesis R05980 -R05981 1 YBR229C Glucosidase 2 subunit alpha (EC 3.2.1.84) (Alpha-glucosidase II subunit alpha) (Glucosidase II subunit alpha) (Reversal of TOR2 lethality protein 2) 3.2.1.84 sce00510 n-glycan biosynthesis R05981 -MNXR101803 1 YBR235W Vacuolar cation-chloride cotransporter 1 (Vacuolar homolog of CCC family protein 1) 3.6.3.7 chloride transport;k+ transport;na transport -MNXR99660 1 ( YBR241C or YGL104C ) Probable metabolite transport protein YBR241C sugar transport -MNXR100023 1 ( YBR241C or YGL104C ) Probable metabolite transport protein YBR241C sugar transport -R01007 1 YBR243C UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosamine phosphotransferase 2.7.8.15 sce00510 n-glycan biosynthesis R01007 -R03916 0 ( YBR281C and YNL191W ) (5-glutamyl)-peptide:amino-acid 5-glutamyltransferase 3.4.-.- sce00480 glutathione metabolism R03916 -MNXR96495 0 YBR295W P-type cation-transporting ATPase (EC 3.6.3.3) (Cadmium resistance protein 2) (Cadmium-translocating P-type ATPase) (Cd(2+)-exporting ATPase) 3.6.3.3 cadmium transport -R11528 1 YCL017C L-cysteine:sulfur-acceptor sulfurtransferase 2.8.1.7 iron-sulfur cluster biosynthesis R11528 -MNXR96713 1 YCR011C Probable ATP-dependent permease cholesterol transport -RXN-9909 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) 1.1.1.- methylglyoxal metabolism -BENZYL-ALCOHOL-DEHYDROGENASE-RXN 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) 1.1.1.- methylglyoxal metabolism -R05347 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) 1.1.1.- methylglyoxal metabolism R05347 -RXN-662 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) 1.1.1.- methylglyoxal metabolism -RXN-8581 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) 1.1.1.- methylglyoxal metabolism -R01763 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Benzyl alcohol:NAD+ oxidoreductase 1.1.1.- methylglyoxal metabolism R01763 -MNXR125914 1 YEL031W Manganese-transporting ATPase 1 (EC 3.6.3.-) 3.6.3.- mn2+ transport -RHEA:45948 1 YEL066W D-amino-acid N-acetyltransferase HPA3 (DNT) (EC 2.3.1.36) (EC 2.3.1.48) (Histone and other protein acetyltransferase 3) 2.3.1.36; 2.3.1.48 other -R00868 1 ( YEL070W or YNR073C ) D-Mannitol:NAD+ 2-oxidoreductase 1.1.1.- sce00051 fructose and mannose metabolism R00868 -R00008 1 YER010C 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming) 4.1.3.17; 4.1.1.3 sce00362 benzoate degradation;sce00660 c5-branched dibasic acid metabolism R00008 -R00217 0 YER010C oxaloacetate carboxy-lyase (pyruvate-forming) 4.1.3.17; 4.1.1.3 sce00362 benzoate degradation;sce00660 c5-branched dibasic acid metabolism R00217 -R07606 1 YER042W L-methionine:thioredoxin-disulfide S-oxidoreductase 1.8.4.11 sce00270 cysteine and methionine metabolism R07606 -R03661 0 YER087W L-proline:tRNA(Pro) ligase (AMP-forming) 6.1.1.15 sce00970 aminoacyl-trna biosynthesis R03661 -R11861 0 YER163C Glutathione-specific gamma-glutamylcyclotransferase (Gamma-GCG) (EC 4.3.2.-) 4.3.2.- sce00480 glutathione metabolism R11861 -R04734 1 YHL018W 4a-hydroxytetrahydrobiopterin hydro-lyase 4.2.1.96 sce00790 folate biosynthesis R04734 -R00275_2 1 YHR008C superoxide:superoxide oxidoreductase 1.15.1.1 sce04146 peroxisome R00275 -R02587 1 ( YHR043C or YHR044C ) 2-Deoxy-D-glucose 6-phosphate phosphohydrolase 3.1.3.68 alternate carbon metabolism R02587 -R03875 1 YHR109W Cytochrome c lysine N-methyltransferase 1 (EC 2.1.1.59) 2.1.1.59 lysine metabolism R03875 -R03938 1 ( YHR119W or YDR440W or YJL168C ) S-Adenosyl-L-methionine:histone-L-lysine N6-methyltransferase 2.1.1.43 lysine metabolism R03938 -MNXR105277 1 YIL023C Zinc transporter YKE4 zinc transport -MNXR105277_2 1 ( YMR243C or YOR316C ) Zinc transporter YKE4 zinc transport -R00100 1 ( YIL043C or YML125C ) NADH:ferricytochrome-b5 oxidoreductase 1.6.2.2 sce00520 amino sugar and nucleotide sugar metabolism R00100 -R00100_2 1 ( YIL043C or YKL150W or YML125C ) NADH-cytochrome b5 reductase 1 (EC 1.6.2.2) (Microsomal cytochrome b reductase) (P35) 1.6.2.2 sce00520 amino sugar and nucleotide sugar metabolism R00100 -RXN-12898 1 YIR036C Benzil reductase ((S)-benzoin forming) IRC24 (EC 1.1.1.320) (Increased recombination centers protein 24) 1.1.1.320 other -R03522 1 YIR038C Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) 2.5.1.18 sce00480 glutathione metabolism R03522 -R03522_2 1 ( YMR251W or YKR076W ) Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) 2.5.1.18 sce00480 glutathione metabolism R03522 -R03522_4 1 YLL060C Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) 2.5.1.18 sce00480 glutathione metabolism R03522 -R02025 1 YKL069W L-methionine:oxidized-thioredoxin S-oxidoreductase 1.8.4.14 sce00270 cysteine and methionine metabolism R02025 -RXN0-6977 1 YKL103C Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I) 3.4.11.22 hydrolysis of peptide bond -RXN0-6979 1 YKL103C Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I) 3.4.11.22 hydrolysis of peptide bond -R00251 0 YKL215C 5-oxo-L-proline amidohydrolase (ATP-hydrolysing) 3.5.2.9 sce00480 glutathione metabolism R00251 -R05758 1 YKL218C threo-3-hydroxy-L-aspartate ammonia-lyase 4.3.1.16 other R05758 -R03522_3 1 YGR154C Glutathione S-transferase omega-like 2 (EC 2.5.1.18) (Extracellular mutant protein 4) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) 2.5.1.18 sce00480 glutathione metabolism R03522 -R01108 1 YKR076W glutathione:dehydroascorbate oxidoreductase 2.5.1.18; 1.8.5.1 sce00480 glutathione metabolism R01108 -R01108_2 1 YGR154C Glutathione S-transferase omega-like 2 (EC 2.5.1.18) (Extracellular mutant protein 4) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) 2.5.1.18; 1.8.5.1 sce00480 glutathione metabolism R01108 -R00778 1 ( YFL061W or YNL335W ) urea hydro-lyase (cyanamide-forming) 4.2.1.69 sce00791 atrazine degradation R00778 -R10089 1 ( YFL060C or YNL334C ) D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5-phosphate-lyase (glutamine-hydrolyzing) 4.3.3.6; 3.5.1.2 sce00750 vitamin b6 metabolism R10089 -R07456 1 ( YFL059W or YNL333W ) D-ribulose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5-phosphate-lyase 4.3.3.6; 3.5.1.2 sce00750 vitamin b6 metabolism R07456 -R00899 1 YFR044C L-cysteinylglycine dipeptidase 3.4.13.- sce00270 cysteine and methionine metabolism R00899 -R04951 1 YFR044C Cys-Gly metallodipeptidase DUG1 (EC 3.4.13.-) (Deficient in utilization of glutathione protein 1) (GSH degradosomal complex subunit DUG1) 3.4.13.- sce00270 cysteine and methionine metabolism R04951 -R00548 1 YDL024C riboflavin-5-phosphate phosphohydrolase 3.1.3.2 sce00730 thiamine metabolism R00548 -R00078 1 YDL120W Fe(II):oxygen oxidoreductase; Fe2+:oxygen oxidoreductase 1.16.3.1 iron-sulfur cluster biosynthesis R00078 -RHEA:53744 1 YDL219W D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (EC 3.1.1.-) 3.1.1.96; 3.1.1.- other -RHEA:25347 1 YDL219W D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (EC 3.1.1.-) 3.1.1.96; 3.1.1.- other -R03024 1 YDL236W 4-nitrophenyl phosphate phosphohydrolase 3.1.3.41 sce00627 aminobenzoate degradation R03024 -R02896 1 YDL246C D-Iditol:NAD+ 2-oxidoreductase 1.1.1.14 sce00040 pentose and glucuronate interconversions R02896 -R01092 0 YDR009W ATP:alpha-D-galactose 1-phosphotransferase sce00052 galactose metabolism R01092 -R03352 1 YDR036C 3-Hydroxy-2-methylpropanoyl-CoA hydrolase 3.1.2.4 valine, leucine and isoleucine metabolism R03352 -RHEA:14633 0 ( YDR038C or YDR039C or YDR040C ) Sodium transport ATPase 5 (EC 3.6.3.7) 3.6.3.7 sodium transport -MNXR124322 1 ( YDR051C or YOL075C ) Broad-range acid phosphatase DET1 (EC 3.1.3.-) (Decreased ergosterol transport protein 1) 3.1.3.- sterols transport -R00258 1 YDR111C L-Alanine:2-oxoglutarate aminotransferase 2.6.1.2 sce00250 alanine, aspartate and glutamate metabolism R00258 -R02540 1 YDR242W 2-phenylacetamide amidohydrolase 3.5.1.4 sce00330 arginine and proline metabolism;sce00360 phenylalanine metabolism;sce00380 tryptophan metabolism R02540 -R03096 1 YDR242W Indole-3-acetamide amidohydrolase 3.5.1.4 sce00330 arginine and proline metabolism;sce00360 phenylalanine metabolism;sce00380 tryptophan metabolism R03096 -R03909 1 YDR242W Monocarboxylic acid amide amidohydrolase 3.5.1.4 sce00330 arginine and proline metabolism;sce00360 phenylalanine metabolism;sce00380 tryptophan metabolism R03909 -R05551 1 YDR242W Probable amidase (EC 3.5.1.4) 3.5.1.4 sce00330 arginine and proline metabolism;sce00360 phenylalanine metabolism;sce00380 tryptophan metabolism R05551 -R05590 1 YDR242W Acylamide aminohydrolase 3.5.1.4 sce00330 arginine and proline metabolism;sce00360 phenylalanine metabolism;sce00380 tryptophan metabolism -R01737 0 YDR248C ATP:D-Gluconate 6-phosphotransferase 2.7.1.12 sce00030 pentose phosphate pathway R01737 -R04496 1 YDR410C S-Adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase 2.1.1.100 sce00900 terpenoid backbone biosynthesis R04496 -R05916 1 ( YDR437W and YGR216C and YNL038W and YPL076W and YPL175W and YPL096C-A ) Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19 (GPI-GlcNAc transferase complex subunit GPI19) (GPI-GnT subunit GPI19) (EC 2.4.1.198) 2.4.1.198 lycosylphosphatidylinositol (gpi)-anchor biosynthesis R05916 -R00299 0 YDR516C ATP:D-glucose 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R00299 -R09796 1 ( YDR533C or YMR322C or YOR391C or YPL280W ) (R)-lactate hydro-lyase 4.2.1.130 methylglyoxal metabolism R09796 -MNXR96434 0 YGL006W Calcium-transporting ATPase 2 (EC 3.6.3.8) (Vacuolar Ca(2+)-ATPase) 3.6.3.8 ca2+ transport -MNXR96434_2 0 YGL167C Calcium-transporting ATPase 2 (EC 3.6.3.8) (Golgi Ca(2+)-ATPase) 3.6.3.8 ca2+ transport -R03862 1 YGL017W L-arginyl-tRNA(Arg):protein arginyltransferase 2.3.2.8 other R03862 -R05976 1 YGL022W Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 (Oligosaccharyl transferase subunit STT3) (EC 2.4.99.18) 2.4.99.18 sce00510 n-glycan biosynthesis R05976 -R05979 1 YGL027C Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) (Glucosidase I) 3.2.1.106 sce00510 n-glycan biosynthesis R05979 -R08599 1 YGL038C Initiation-specific alpha-1,6-mannosyltransferase (EC 2.4.1.232) (Outer chain elongation protein 1) 2.4.1.232 sce00513 various types of n-glycan biosynthesis R08599 -R05973 1 YGL065C Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase) 2.4.1.132; 2.4.1.257 sce00510 n-glycan biosynthesis R05973 -R06238 1 YGL065C GDP-D-mannose:D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-6-mannosyltransferase 2.4.1.132; 2.4.1.257 sce00510 n-glycan biosynthesis R06238 -R09645 0 YGL156W 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate 6-phosphomannohydrolase 3.2.1.24 sce00511 other glycan degradation R09645 -3.2.1.24-RXN 0 YGL156W Alpha-mannosidase (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) 3.2.1.24 sce00511 other glycan degradation -R10463 0 YGL169W ATP:L-threonyl,bicarbonate adenylyltransferase 2.7.7.87 other R10463 -R00221 1 YGL196W D-serine ammonia-lyase 4.3.1.18 sce00260 glycine, serine and threonine metabolism R00221 -R00897 1 YGR012W O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase; O3-acetyl-L-serine acetate-lyase (adding hydrogen sulfide) 2.5.1.47 sce00270 cysteine and methionine metabolism R00897 -R01004 1 YGR036C Dolichyl-diphosphate phosphohydrolase 3.6.1.43 sce00510 n-glycan biosynthesis R01004 -R01799 1 YGR046W CTP:phosphatidate cytidyltransferase 2.7.7.41 sce00564 glycerophospholipid metabolism R01799 -R10685 1 YGR144W Thiamine thiazole synthase (Thiazole biosynthetic enzyme) sce00730 thiamine metabolism R10685 -R06264 1 YGR227W dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-glucosyltransferase 2.4.1.256 sce00510 n-glycan biosynthesis R06264 -R05725 0 YGR234W nitric oxide, NADPH2:oxygen oxidoreductase 1.14.12.17 sce00910 nitrogen metabolism R05725 -R05725_2 0 YGR234W Flavohemoprotein (EC 1.14.12.17) (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) 1.14.12.17 sce00910 nitrogen metabolism R05725 -R07770 0 YJL046W Putative lipoate-protein ligase A (EC 6.3.1.20) (Altered inheritance rate of mitochondria protein 22) 6.3.1.20 sce00785 lipoic acid metabolism R07770 -R11143 0 YJL046W [lipoyl-carrier protein]-L-lysine:lipoate ligase (AMP-forming) 6.3.1.20 sce00785 lipoic acid metabolism R11143 -R12024 1 YJL126W Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.-) (Nitrilase homolog 1) 3.5.1.- other R12024 -R12024_2 1 YJL126W Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.-) (Nitrilase homolog 1) 3.5.1.- other R12024 -R01324 1 YJL200C citrate hydroxymutase 4.2.1.- lysine metabolism;sce00020 citrate cycle (tca cycle) R01324 -MNXR96797 1 YJR040W Anion/proton exchange transporter GEF1 (CLC protein GEF1) (ClC-A) (ClC-Y1) (Voltage-gated chloride channel) [Cleaved into: GEF1 N-terminal; GEF1 C-terminal] chloride transport -R00402 1 YJR051W succinate:NAD+ oxidoreductase 1.3.1.6 sce00720 carbon fixation pathways in prokaryotes R00402 -R01532 0 YJR069C nucleoside-triphosphate diphosphohydrolase 3.6.1.9 sce00230 purine metabolism R01532 -RXN0-384 0 YJR069C Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Hydroxylaminopurine sensitivity protein 1) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) 3.6.1.9 sce00230 purine metabolism -R01855 0 YJR069C 2'-Deoxyguanosine 5'-triphosphate diphosphohydrolase 3.6.1.9 sce00230 purine metabolism R01855 -R11323 0 YJR069C dTTP diphosphohydrolase 3.6.1.9 sce00230 purine metabolism R11323 -3.6.1.19-RXN 1 YJR069C Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Hydroxylaminopurine sensitivity protein 1) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) 3.6.1.9 sce00230 purine metabolism -R00275 1 YJR104C superoxide:superoxide oxidoreductase 1.15.1.1 sce04146 peroxisome R00275 -R05982 1 ( YJR131W or YLR057W ) Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Man(9)-alpha-mannosidase) 3.2.1.113;3.2.1.- sce00510 n-glycan biosynthesis R05982 -R06722 1 ( YJR131W or YLR057W ) alpha 1,2-mannosyloligosaccharide alpha-D-mannohydrolase 3.2.1.113;3.2.1.- sce00510 n-glycan biosynthesis R06722 -R00025 1 YJR149W ethylnitronate:oxygen 2-oxidoreductase (nitrite-forming) 1.13.12.16 sce00910 nitrogen metabolism R00025 -R00999 1 ( YLL058W or YML082W ) O-Succinyl-L-homoserine succinate-lyase (deaminating; 2-oxobutanoate-forming) 2.5.1.48 sce00270 cysteine and methionine metabolism R00999 -R09541 1 ( YLR047C or YKL220C or YLR214W or YNR060W or YOL152W or YOR381W or YOR384W ) Fe(II):NADP+ oxidoreductase 1.16.1.7 ferric-chelate reductase R09541 -R09541_2 1 YLL051C Fe(II):NADP+ oxidoreductase 1.16.1.7 ferric-chelate reductase R09541 -R00851 1 ( YLR099C or YPR139C ) acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase 2.3.1.51 sce00561 glycerolipid metabolism;sce00564 glycerophospholipid metabolism R00851 -R03613 0 YLR143W diphthine:ammonia ligase (AMP-forming) 6.3.1.14 diphthamide biosynthesis R03613 -R09832 1 YLR151C 8-oxo-dGTP diphosphohydrolase 3.6.1.55 other R09832 -R07766 1 YLR239C octanoyl-[acp]:protein N6-octanoyltransferase 2.3.1.181 sce00785 lipoic acid metabolism R07766 -R07769 1 YLR239C lipoyl-[acp]:protein N6-lipoyltransferase 2.3.1.181 sce00785 lipoic acid metabolism R07769 -R02732 0 YLR345W ATP:D-fructose-6-phosphate 2-phosphotransferase 2.7.1.105; 3.1.3.46 sce00051 fructose and mannose metabolism R02732 -R00867 0 YLR446W ATP:D-fructose 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R00867 -R01600 0 YLR446W ATP:beta-D-glucose 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R01600 -R01786 0 YLR446W ATP:alpha-D-glucose 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R01786 -R01961 0 YLR446W ATP:D-glucosamine 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R01961 -R03920 0 YLR446W ATP:D-fructose 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R03920 -R02739 1 YMR099C alpha-D-Glucose 6-phosphate ketol-isomerase 5.1.3.15 sce00010 glycolysis / gluconeogenesis R02739 -R01752 1 YMR110C D-Glyceraldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R01752 -R01986 1 YMR110C 4-Aminobutyraldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R01986 -R02549 0 YMR110C 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R02549 -R02678 0 YMR110C Indole-3-acetaldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R02678 -R02940 1 YMR110C 2-Propyn-1-al:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R02940 -R02957 1 YMR110C D-Glucuronolactone:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R02957 -R03283 1 YMR110C 4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase; 4-Trimethylammoniobutanal:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R03283 -R03869 1 YMR110C (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R03869 -R04065 1 YMR110C Imidazole acetaldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R04065 -R04506 1 YMR110C 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R04506 -R04903 1 YMR110C 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R04903 -R05050 1 YMR110C N4-Acetylaminobutanal:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R05050 -R05237 1 YMR110C Fatty aldehyde dehydrogenase HFD1 (EC 1.2.1.3) 1.2.1.3 sce00600 sphingolipid metabolism R05237 -R05238 1 YMR110C Fatty aldehyde dehydrogenase HFD1 (EC 1.2.1.3) 1.2.1.3 sce00600 sphingolipid metabolism R05238 -R05286 1 YMR110C Chloroacetaldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R05286 -R06366 1 YMR110C Aldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R06366 -R08146 1 YMR110C farnesal:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R08146 -MNXR125804 0 YMR162C Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 3.6.3.1 phospholipids transport -RXN-15089 0 YMR210W Putative esterase YMR210W (EC 3.1.1.-) 3.1.1.- sce00564 glycerophospholipid metabolism -R06127 1 YNL048W GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase 2.4.1.131 sce00510 n-glycan biosynthesis R06127 -R06128 1 YNL048W GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase 2.4.1.131 sce00510 n-glycan biosynthesis R06128 -R02144 1 YNL092W S-adenosyl-L-methionine:carnosine N-methyltransferase 2.1.1.22 sce00340 histidine metabolism R02144 -R06259 1 YNL219C Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) 2.4.1.259; 2.4.1.261 sce00510 n-glycan biosynthesis R06259 -R06261 1 YNL219C Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) 2.4.1.259; 2.4.1.261 sce00510 n-glycan biosynthesis R06261 -R00717 1 YNL274C Glycolate:NAD+ oxidoreductase 1.1.1.26 sce00630 glyoxylate and dicarboxylate metabolism R00717 -R06260 1 YNR030W Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Extracellular mutant protein 39) (Mannosyltransferase ALG12) 2.4.1.260 sce00510 n-glycan biosynthesis R06260 -R00801 1 YOL157C sucrose glucohydrolase 3.2.1.10 sce00500 starch and sucrose metabolism R00801 -R01718 1 YOL157C Isomaltose 6-alpha-D-glucanohydrolase 3.2.1.10 sce00500 starch and sucrose metabolism R01718 -R01791 1 YOL157C Dextrin 6-alpha-D-glucanohydrolase 3.2.1.10 sce00500 starch and sucrose metabolism R01791 -R06262 1 YOR002W dolichyl beta-D-glucosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase 2.4.1.267 sce00510 n-glycan biosynthesis R06262 -R06263 1 YOR067C dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase 2.4.1.265 sce00510 n-glycan biosynthesis R06263 -R07129 1 YOR149C GPI mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) 2.4.1.- sce00563 glycosylphosphatidylinositol (gpi)-anchor biosynthesis R07129 -R07767 1 YOR196C protein N6-(octanoyl)lysine:sulfur sulfurtransferase 2.8.1.8 sce00785 lipoic acid metabolism R07767 -R07768 1 YOR196C octanoyl-[acp]:sulfur sulfurtransferase 2.8.1.8 sce00785 lipoic acid metabolism R07768 -RXN-14381 0 ( YOR226C or YPL135W ) Iron sulfur cluster assembly protein 2, mitochondrial (Iron sulfur cluster scaffold protein 2) iron-sulfur cluster biosynthesis -R01931 1 ( YOR251C or YOR285W or YOR286W ) thiosulfate:cyanide sulfurtranserase 2.8.1.1;2.8.1.- sce00920 sulfur metabolism R01931 -MNXR101505 1 ( YOR334W or YPL060W ) Magnesium transporter MRS2, mitochondrial (RNA-splicing protein MRS2) magnesium transport -R01005 1 YPL227C UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase 2.4.1.117 sce00510 n-glycan biosynthesis R01005 -MNXR104466 1 YPR003C Putative sulfate transporter YPR003C sulfate transport -R01708 1 YPR127W Pyridoxine:NADP+ 4-oxidoreductase 1.1.1.65 sce00750 vitamin b6 metabolism R01708 -R01206 1 ( YDR371W or YLR286C ) [1,4-(N-Acetyl-beta-D-glucosaminyl)]n glycanohydrolase 3.2.1.14 sce00520 amino sugar and nucleotide sugar metabolism R01206 -MNXR96691 1 YOR161C Protein PNS1 (pH nine-sensitive protein 1) choline transport -R03042 1 ( YHR201C or YDR452W ) Polyphosphate phosphohydrolase 3.6.1.10; 3.6.1.-; 3.6.1.11 cofactor and prosthetic group biosynthesis R03042 -MNXR96952 0 YDR270W Copper-transporting ATPase (EC 3.6.3.54) (Cu(2+)-ATPase) 3.6.3.54 cu2+ transport -RXN-14214 0 YDR452W Endopolyphosphatase (EC 3.6.1.10) (Deoxyadenosine triphosphate phosphohydrolase) (dATP phosphohydrolase) (EC 3.6.1.-) (Exopolyphosphatase) (EC 3.6.1.11) (Phosphate metabolism protein 5) 3.6.1.10; 3.6.1.-; 3.6.1.11 other -R03804 1 YLR351C Monoamide of a dicarboxylic acid amidohydrolase 3.5.1.3 other R03804 -MNXR124629 1 YMR301C Iron-sulfur clusters transporter ATM1, mitochondrial porphyrin transport -R06199 1 YOL157C Oligo-1,6-glucosidase IMA2 (EC 3.2.1.10) (Alpha-glucosidase) (Isomaltase 2) 3.2.1.10 sce00500 starch and sucrose metabolism R06199 -MNXR99010 1 YEL004W UDP-N-acetylglucosamine transporter YEA4 uridine diphosphate-n-acetylglucosamine (udp-glcnac) transport +RxnID REV GPR RxnName EC Subsystems RxnKEGGid +R02480 1 ( YAL039C or YKL087C ) Cytochrome c apocytochrome-c-lyase 4.4.1.17;4.4.1.- sce00860 porphyrin and chlorophyll metabolism R02480 +R02855 1 YAL061W (R)-Acetoin:NAD+ oxidoreductase 1.1.1.303 sce00650 butanoate metabolism R02855 +R02855_2 1 YAL061W Probable diacetyl reductase [(R)-acetoin forming] 2 (EC 1.1.1.303) 1.1.1.303 sce00650 butanoate metabolism R02855 +6.3.5.6-RXN 0 YBL080C Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112) 6.3.5.- sce00970 aminoacyl-trna biosynthesis +MNXR100968 1 ( YBL091C or YLR244C ) Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M) 3.4.11.18 other +MNXR116282 1 ( YBR022W or YMR087W ) ADP-ribose 1''-phosphate phosphatase (EC 3.1.3.84) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase) 3.1.3.84; 3.2.2.- other +R02364 1 YBR046C NADPH2:quinone oxidoreductase 1.6.5.5 sce00350 tyrosine metabolism R02364 +R05970 1 ( YBR070C and YGL047W ) UDP-N-acetylglucosamine transferase subunit ALG14 (Asparagine-linked glycosylation protein 14) 2.4.1.141 sce00510 n-glycan biosynthesis R05970 +MNXR106807 1 YBR111C ADP-ribose pyrophosphatase (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) 3.6.1.13 sce00230 purine metabolism +MNXR95951 1 ( YBR147W or YDR352W ) Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) l-arg transport (from lysosomal lumen to cytosol);l-his transport (from lysosomal lumen to cytosol);l-lys transport (from lysoso... +MNXR100645 1 ( YBR147W or YDR352W ) Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) l-arg transport (from lysosomal lumen to cytosol);l-his transport (from lysosomal lumen to cytosol);l-lys transport (from lysoso... +MNXR101266 1 ( YBR147W or YDR352W ) Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) l-arg transport (from lysosomal lumen to cytosol);l-his transport (from lysosomal lumen to cytosol);l-lys transport (from lysoso... +R01558 1 YBR222C oxalate:CoA ligase (AMP-forming) 6.-.-.- sce00630 glyoxylate and dicarboxylate metabolism R01558 +R05980 1 YBR229C Glucosidase 2 subunit alpha (EC 3.2.1.84) (Alpha-glucosidase II subunit alpha) (Glucosidase II subunit alpha) (Reversal of TOR2 lethality protein 2) 3.2.1.84 sce00510 n-glycan biosynthesis R05980 +R05981 1 YBR229C Glucosidase 2 subunit alpha (EC 3.2.1.84) (Alpha-glucosidase II subunit alpha) (Glucosidase II subunit alpha) (Reversal of TOR2 lethality protein 2) 3.2.1.84 sce00510 n-glycan biosynthesis R05981 +MNXR101803 1 YBR235W Vacuolar cation-chloride cotransporter 1 (Vacuolar homolog of CCC family protein 1) 3.6.3.7 chloride transport;k+ transport;na transport +MNXR99660 1 ( YBR241C or YGL104C ) Probable metabolite transport protein YBR241C sugar transport +MNXR100023 1 ( YBR241C or YGL104C ) Probable metabolite transport protein YBR241C sugar transport +R01007 1 YBR243C UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosamine phosphotransferase 2.7.8.15 sce00510 n-glycan biosynthesis R01007 +R03916 0 ( YBR281C and YNL191W ) (5-glutamyl)-peptide:amino-acid 5-glutamyltransferase 3.4.-.- sce00480 glutathione metabolism R03916 +MNXR96495 0 YBR295W P-type cation-transporting ATPase (EC 3.6.3.3) (Cadmium resistance protein 2) (Cadmium-translocating P-type ATPase) (Cd(2+)-exporting ATPase) 3.6.3.3 cadmium transport +R11528 1 YCL017C L-cysteine:sulfur-acceptor sulfurtransferase 2.8.1.7 iron-sulfur cluster biosynthesis R11528 +MNXR96713 1 YCR011C Probable ATP-dependent permease cholesterol transport +RXN-9909 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) 1.1.1.- methylglyoxal metabolism +BENZYL-ALCOHOL-DEHYDROGENASE-RXN 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) 1.1.1.- methylglyoxal metabolism +R05347 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) 1.1.1.- methylglyoxal metabolism R05347 +RXN-662 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) 1.1.1.- methylglyoxal metabolism +RXN-8581 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) 1.1.1.- methylglyoxal metabolism +R01763 1 ( YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W ) Benzyl alcohol:NAD+ oxidoreductase 1.1.1.- methylglyoxal metabolism R01763 +MNXR125914 1 YEL031W Manganese-transporting ATPase 1 (EC 3.6.3.-) 3.6.3.- mn2+ transport +RHEA:45948 1 YEL066W D-amino-acid N-acetyltransferase HPA3 (DNT) (EC 2.3.1.36) (EC 2.3.1.48) (Histone and other protein acetyltransferase 3) 2.3.1.36; 2.3.1.48 other +R00868 1 ( YEL070W or YNR073C ) D-Mannitol:NAD+ 2-oxidoreductase 1.1.1.- sce00051 fructose and mannose metabolism R00868 +R00008 1 YER010C 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming) 4.1.3.17; 4.1.1.3 sce00362 benzoate degradation;sce00660 c5-branched dibasic acid metabolism R00008 +R00217 0 YER010C oxaloacetate carboxy-lyase (pyruvate-forming) 4.1.3.17; 4.1.1.3 sce00362 benzoate degradation;sce00660 c5-branched dibasic acid metabolism R00217 +R07606 1 YER042W L-methionine:thioredoxin-disulfide S-oxidoreductase 1.8.4.11 sce00270 cysteine and methionine metabolism R07606 +R03661 0 YER087W L-proline:tRNA(Pro) ligase (AMP-forming) 6.1.1.15 sce00970 aminoacyl-trna biosynthesis R03661 +R11861 0 YER163C Glutathione-specific gamma-glutamylcyclotransferase (Gamma-GCG) (EC 4.3.2.-) 4.3.2.- sce00480 glutathione metabolism R11861 +R04734 1 YHL018W 4a-hydroxytetrahydrobiopterin hydro-lyase 4.2.1.96 sce00790 folate biosynthesis R04734 +R00275_2 1 YHR008C superoxide:superoxide oxidoreductase 1.15.1.1 sce04146 peroxisome R00275 +R02587 1 ( YHR043C or YHR044C ) 2-Deoxy-D-glucose 6-phosphate phosphohydrolase 3.1.3.68 alternate carbon metabolism R02587 +R03875 1 YHR109W Cytochrome c lysine N-methyltransferase 1 (EC 2.1.1.59) 2.1.1.59 lysine metabolism R03875 +R03938 1 ( YHR119W or YDR440W or YJL168C ) S-Adenosyl-L-methionine:histone-L-lysine N6-methyltransferase 2.1.1.43 lysine metabolism R03938 +MNXR105277 1 YIL023C Zinc transporter YKE4 zinc transport +MNXR105277_2 1 ( YMR243C or YOR316C ) Zinc transporter YKE4 zinc transport +R00100 1 ( YIL043C or YML125C ) NADH:ferricytochrome-b5 oxidoreductase 1.6.2.2 sce00520 amino sugar and nucleotide sugar metabolism R00100 +R00100_2 1 ( YIL043C or YKL150W or YML125C ) NADH-cytochrome b5 reductase 1 (EC 1.6.2.2) (Microsomal cytochrome b reductase) (P35) 1.6.2.2 sce00520 amino sugar and nucleotide sugar metabolism R00100 +RXN-12898 1 YIR036C Benzil reductase ((S)-benzoin forming) IRC24 (EC 1.1.1.320) (Increased recombination centers protein 24) 1.1.1.320 other +R03522 1 YIR038C Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) 2.5.1.18 sce00480 glutathione metabolism R03522 +R03522_2 1 ( YMR251W or YKR076W ) Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) 2.5.1.18 sce00480 glutathione metabolism R03522 +R03522_4 1 YLL060C Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) 2.5.1.18 sce00480 glutathione metabolism R03522 +R02025 1 YKL069W L-methionine:oxidized-thioredoxin S-oxidoreductase 1.8.4.14 sce00270 cysteine and methionine metabolism R02025 +RXN0-6977 1 YKL103C Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I) 3.4.11.22 hydrolysis of peptide bond +RXN0-6979 1 YKL103C Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I) 3.4.11.22 hydrolysis of peptide bond +R00251 0 YKL215C 5-oxo-L-proline amidohydrolase (ATP-hydrolysing) 3.5.2.9 sce00480 glutathione metabolism R00251 +R05758 1 YKL218C threo-3-hydroxy-L-aspartate ammonia-lyase 4.3.1.16 other R05758 +R03522_3 1 YGR154C Glutathione S-transferase omega-like 2 (EC 2.5.1.18) (Extracellular mutant protein 4) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) 2.5.1.18 sce00480 glutathione metabolism R03522 +R01108 1 YKR076W glutathione:dehydroascorbate oxidoreductase 2.5.1.18; 1.8.5.1 sce00480 glutathione metabolism R01108 +R01108_2 1 YGR154C Glutathione S-transferase omega-like 2 (EC 2.5.1.18) (Extracellular mutant protein 4) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) 2.5.1.18; 1.8.5.1 sce00480 glutathione metabolism R01108 +R00778 1 ( YFL061W or YNL335W ) urea hydro-lyase (cyanamide-forming) 4.2.1.69 sce00791 atrazine degradation R00778 +R10089 1 ( YFL060C or YNL334C ) D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5-phosphate-lyase (glutamine-hydrolyzing) 4.3.3.6; 3.5.1.2 sce00750 vitamin b6 metabolism R10089 +R07456 1 ( YFL059W or YNL333W ) D-ribulose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5-phosphate-lyase 4.3.3.6; 3.5.1.2 sce00750 vitamin b6 metabolism R07456 +R00899 1 YFR044C L-cysteinylglycine dipeptidase 3.4.13.- sce00270 cysteine and methionine metabolism R00899 +R04951 1 YFR044C Cys-Gly metallodipeptidase DUG1 (EC 3.4.13.-) (Deficient in utilization of glutathione protein 1) (GSH degradosomal complex subunit DUG1) 3.4.13.- sce00270 cysteine and methionine metabolism R04951 +R00548 1 YDL024C riboflavin-5-phosphate phosphohydrolase 3.1.3.2 sce00730 thiamine metabolism R00548 +R00078 1 YDL120W Fe(II):oxygen oxidoreductase; Fe2+:oxygen oxidoreductase 1.16.3.1 iron-sulfur cluster biosynthesis R00078 +RHEA:53744 1 YDL219W D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (EC 3.1.1.-) 3.1.1.96; 3.1.1.- other +RHEA:25347 1 YDL219W D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (EC 3.1.1.-) 3.1.1.96; 3.1.1.- other +R03024 1 YDL236W 4-nitrophenyl phosphate phosphohydrolase 3.1.3.41 sce00627 aminobenzoate degradation R03024 +R02896 1 YDL246C D-Iditol:NAD+ 2-oxidoreductase 1.1.1.14 sce00040 pentose and glucuronate interconversions R02896 +R01092 0 YDR009W ATP:alpha-D-galactose 1-phosphotransferase sce00052 galactose metabolism R01092 +R03352 1 YDR036C 3-Hydroxy-2-methylpropanoyl-CoA hydrolase 3.1.2.4 valine, leucine and isoleucine metabolism R03352 +RHEA:14633 0 ( YDR038C or YDR039C or YDR040C ) Sodium transport ATPase 5 (EC 3.6.3.7) 3.6.3.7 sodium transport +MNXR124322 1 ( YDR051C or YOL075C ) Broad-range acid phosphatase DET1 (EC 3.1.3.-) (Decreased ergosterol transport protein 1) 3.1.3.- sterols transport +R00258 1 YDR111C L-Alanine:2-oxoglutarate aminotransferase 2.6.1.2 sce00250 alanine, aspartate and glutamate metabolism R00258 +R02540 1 YDR242W 2-phenylacetamide amidohydrolase 3.5.1.4 sce00330 arginine and proline metabolism;sce00360 phenylalanine metabolism;sce00380 tryptophan metabolism R02540 +R03096 1 YDR242W Indole-3-acetamide amidohydrolase 3.5.1.4 sce00330 arginine and proline metabolism;sce00360 phenylalanine metabolism;sce00380 tryptophan metabolism R03096 +R03909 1 YDR242W Monocarboxylic acid amide amidohydrolase 3.5.1.4 sce00330 arginine and proline metabolism;sce00360 phenylalanine metabolism;sce00380 tryptophan metabolism R03909 +R05551 1 YDR242W Probable amidase (EC 3.5.1.4) 3.5.1.4 sce00330 arginine and proline metabolism;sce00360 phenylalanine metabolism;sce00380 tryptophan metabolism R05551 +R05590 1 YDR242W Acylamide aminohydrolase 3.5.1.4 sce00330 arginine and proline metabolism;sce00360 phenylalanine metabolism;sce00380 tryptophan metabolism +R01737 0 YDR248C ATP:D-Gluconate 6-phosphotransferase 2.7.1.12 sce00030 pentose phosphate pathway R01737 +R04496 1 YDR410C S-Adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase 2.1.1.100 sce00900 terpenoid backbone biosynthesis R04496 +R05916 1 ( YDR437W and YGR216C and YNL038W and YPL076W and YPL175W and YPL096C-A ) Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19 (GPI-GlcNAc transferase complex subunit GPI19) (GPI-GnT subunit GPI19) (EC 2.4.1.198) 2.4.1.198 lycosylphosphatidylinositol (gpi)-anchor biosynthesis R05916 +R00299 0 YDR516C ATP:D-glucose 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R00299 +R09796 1 ( YDR533C or YMR322C or YOR391C or YPL280W ) (R)-lactate hydro-lyase 4.2.1.130 methylglyoxal metabolism R09796 +MNXR96434 0 YGL006W Calcium-transporting ATPase 2 (EC 3.6.3.8) (Vacuolar Ca(2+)-ATPase) 3.6.3.8 ca2+ transport +MNXR96434_2 0 YGL167C Calcium-transporting ATPase 2 (EC 3.6.3.8) (Golgi Ca(2+)-ATPase) 3.6.3.8 ca2+ transport +R03862 1 YGL017W L-arginyl-tRNA(Arg):protein arginyltransferase 2.3.2.8 other R03862 +R05976 1 YGL022W Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 (Oligosaccharyl transferase subunit STT3) (EC 2.4.99.18) 2.4.99.18 sce00510 n-glycan biosynthesis R05976 +R05979 1 YGL027C Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) (Glucosidase I) 3.2.1.106 sce00510 n-glycan biosynthesis R05979 +R08599 1 YGL038C Initiation-specific alpha-1,6-mannosyltransferase (EC 2.4.1.232) (Outer chain elongation protein 1) 2.4.1.232 sce00513 various types of n-glycan biosynthesis R08599 +R05973 1 YGL065C Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase) 2.4.1.132; 2.4.1.257 sce00510 n-glycan biosynthesis R05973 +R06238 1 YGL065C GDP-D-mannose:D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-6-mannosyltransferase 2.4.1.132; 2.4.1.257 sce00510 n-glycan biosynthesis R06238 +R09645 0 YGL156W 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate 6-phosphomannohydrolase 3.2.1.24 sce00511 other glycan degradation R09645 +3.2.1.24-RXN 0 YGL156W Alpha-mannosidase (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) 3.2.1.24 sce00511 other glycan degradation +R10463 0 YGL169W ATP:L-threonyl,bicarbonate adenylyltransferase 2.7.7.87 other R10463 +R00221 1 YGL196W D-serine ammonia-lyase 4.3.1.18 sce00260 glycine, serine and threonine metabolism R00221 +R00897 1 YGR012W O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase; O3-acetyl-L-serine acetate-lyase (adding hydrogen sulfide) 2.5.1.47 sce00270 cysteine and methionine metabolism R00897 +R01004 1 YGR036C Dolichyl-diphosphate phosphohydrolase 3.6.1.43 sce00510 n-glycan biosynthesis R01004 +R01799 1 YGR046W CTP:phosphatidate cytidyltransferase 2.7.7.41 sce00564 glycerophospholipid metabolism R01799 +R10685 1 YGR144W Thiamine thiazole synthase (Thiazole biosynthetic enzyme) sce00730 thiamine metabolism R10685 +R06264 1 YGR227W dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-glucosyltransferase 2.4.1.256 sce00510 n-glycan biosynthesis R06264 +R05725 0 YGR234W nitric oxide, NADPH2:oxygen oxidoreductase 1.14.12.17 sce00910 nitrogen metabolism R05725 +R05725_2 0 YGR234W Flavohemoprotein (EC 1.14.12.17) (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) 1.14.12.17 sce00910 nitrogen metabolism R05725 +R07770 0 YJL046W Putative lipoate-protein ligase A (EC 6.3.1.20) (Altered inheritance rate of mitochondria protein 22) 6.3.1.20 sce00785 lipoic acid metabolism R07770 +R11143 0 YJL046W [lipoyl-carrier protein]-L-lysine:lipoate ligase (AMP-forming) 6.3.1.20 sce00785 lipoic acid metabolism R11143 +R12024 1 YJL126W Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.-) (Nitrilase homolog 1) 3.5.1.- other R12024 +R12024_2 1 YJL126W Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.-) (Nitrilase homolog 1) 3.5.1.- other R12024 +R01324 1 YJL200C citrate hydroxymutase 4.2.1.- lysine metabolism;sce00020 citrate cycle (tca cycle) R01324 +MNXR96797 1 YJR040W Anion/proton exchange transporter GEF1 (CLC protein GEF1) (ClC-A) (ClC-Y1) (Voltage-gated chloride channel) [Cleaved into: GEF1 N-terminal; GEF1 C-terminal] chloride transport +R00402 1 YJR051W succinate:NAD+ oxidoreductase 1.3.1.6 sce00720 carbon fixation pathways in prokaryotes R00402 +R01532 0 YJR069C nucleoside-triphosphate diphosphohydrolase 3.6.1.9 sce00230 purine metabolism R01532 +RXN0-384 0 YJR069C Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Hydroxylaminopurine sensitivity protein 1) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) 3.6.1.9 sce00230 purine metabolism +R01855 0 YJR069C 2'-Deoxyguanosine 5'-triphosphate diphosphohydrolase 3.6.1.9 sce00230 purine metabolism R01855 +R11323 0 YJR069C dTTP diphosphohydrolase 3.6.1.9 sce00230 purine metabolism R11323 +3.6.1.19-RXN 1 YJR069C Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Hydroxylaminopurine sensitivity protein 1) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) 3.6.1.9 sce00230 purine metabolism +R00275 1 YJR104C superoxide:superoxide oxidoreductase 1.15.1.1 sce04146 peroxisome R00275 +R05982 1 ( YJR131W or YLR057W ) Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Man(9)-alpha-mannosidase) 3.2.1.113;3.2.1.- sce00510 n-glycan biosynthesis R05982 +R06722 1 ( YJR131W or YLR057W ) alpha 1,2-mannosyloligosaccharide alpha-D-mannohydrolase 3.2.1.113;3.2.1.- sce00510 n-glycan biosynthesis R06722 +R00025 1 YJR149W ethylnitronate:oxygen 2-oxidoreductase (nitrite-forming) 1.13.12.16 sce00910 nitrogen metabolism R00025 +R00999 1 ( YLL058W or YML082W ) O-Succinyl-L-homoserine succinate-lyase (deaminating; 2-oxobutanoate-forming) 2.5.1.48 sce00270 cysteine and methionine metabolism R00999 +R09541 1 ( YLR047C or YKL220C or YLR214W or YNR060W or YOL152W or YOR381W or YOR384W ) Fe(II):NADP+ oxidoreductase 1.16.1.7 ferric-chelate reductase R09541 +R09541_2 1 YLL051C Fe(II):NADP+ oxidoreductase 1.16.1.7 ferric-chelate reductase R09541 +R00851 1 ( YLR099C or YPR139C ) acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase 2.3.1.51 sce00561 glycerolipid metabolism;sce00564 glycerophospholipid metabolism R00851 +R03613 0 YLR143W diphthine:ammonia ligase (AMP-forming) 6.3.1.14 diphthamide biosynthesis R03613 +R09832 1 YLR151C 8-oxo-dGTP diphosphohydrolase 3.6.1.55 other R09832 +R07766 1 YLR239C octanoyl-[acp]:protein N6-octanoyltransferase 2.3.1.181 sce00785 lipoic acid metabolism R07766 +R07769 1 YLR239C lipoyl-[acp]:protein N6-lipoyltransferase 2.3.1.181 sce00785 lipoic acid metabolism R07769 +R02732 0 YLR345W ATP:D-fructose-6-phosphate 2-phosphotransferase 2.7.1.105; 3.1.3.46 sce00051 fructose and mannose metabolism R02732 +R00867 0 YLR446W ATP:D-fructose 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R00867 +R01600 0 YLR446W ATP:beta-D-glucose 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R01600 +R01786 0 YLR446W ATP:alpha-D-glucose 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R01786 +R01961 0 YLR446W ATP:D-glucosamine 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R01961 +R03920 0 YLR446W ATP:D-fructose 6-phosphotransferase 2.7.1.1 sce00010 glycolysis / gluconeogenesis R03920 +R02739 1 YMR099C alpha-D-Glucose 6-phosphate ketol-isomerase 5.1.3.15 sce00010 glycolysis / gluconeogenesis R02739 +R01752 1 YMR110C D-Glyceraldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R01752 +R01986 1 YMR110C 4-Aminobutyraldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R01986 +R02549 0 YMR110C 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R02549 +R02678 0 YMR110C Indole-3-acetaldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R02678 +R02940 1 YMR110C 2-Propyn-1-al:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R02940 +R02957 1 YMR110C D-Glucuronolactone:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R02957 +R03283 1 YMR110C 4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase; 4-Trimethylammoniobutanal:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R03283 +R03869 1 YMR110C (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R03869 +R04065 1 YMR110C Imidazole acetaldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R04065 +R04506 1 YMR110C 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R04506 +R04903 1 YMR110C 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R04903 +R05050 1 YMR110C N4-Acetylaminobutanal:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R05050 +R05237 1 YMR110C Fatty aldehyde dehydrogenase HFD1 (EC 1.2.1.3) 1.2.1.3 sce00600 sphingolipid metabolism R05237 +R05238 1 YMR110C Fatty aldehyde dehydrogenase HFD1 (EC 1.2.1.3) 1.2.1.3 sce00600 sphingolipid metabolism R05238 +R05286 1 YMR110C Chloroacetaldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R05286 +R06366 1 YMR110C Aldehyde:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R06366 +R08146 1 YMR110C farnesal:NAD+ oxidoreductase 1.2.1.3 sce00600 sphingolipid metabolism R08146 +MNXR125804 0 YMR162C Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 3.6.3.1 phospholipids transport +RXN-15089 0 YMR210W Putative esterase YMR210W (EC 3.1.1.-) 3.1.1.- sce00564 glycerophospholipid metabolism +R06127 1 YNL048W GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase 2.4.1.131 sce00510 n-glycan biosynthesis R06127 +R06128 1 YNL048W GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase 2.4.1.131 sce00510 n-glycan biosynthesis R06128 +R02144 1 YNL092W S-adenosyl-L-methionine:carnosine N-methyltransferase 2.1.1.22 sce00340 histidine metabolism R02144 +R06259 1 YNL219C Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) 2.4.1.259; 2.4.1.261 sce00510 n-glycan biosynthesis R06259 +R06261 1 YNL219C Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) 2.4.1.259; 2.4.1.261 sce00510 n-glycan biosynthesis R06261 +R00717 1 YNL274C Glycolate:NAD+ oxidoreductase 1.1.1.26 sce00630 glyoxylate and dicarboxylate metabolism R00717 +R06260 1 YNR030W Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Extracellular mutant protein 39) (Mannosyltransferase ALG12) 2.4.1.260 sce00510 n-glycan biosynthesis R06260 +R00801 1 YOL157C sucrose glucohydrolase 3.2.1.10 sce00500 starch and sucrose metabolism R00801 +R01718 1 YOL157C Isomaltose 6-alpha-D-glucanohydrolase 3.2.1.10 sce00500 starch and sucrose metabolism R01718 +R01791 1 YOL157C Dextrin 6-alpha-D-glucanohydrolase 3.2.1.10 sce00500 starch and sucrose metabolism R01791 +R06262 1 YOR002W dolichyl beta-D-glucosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase 2.4.1.267 sce00510 n-glycan biosynthesis R06262 +R06263 1 YOR067C dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase 2.4.1.265 sce00510 n-glycan biosynthesis R06263 +R07129 1 YOR149C GPI mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) 2.4.1.- sce00563 glycosylphosphatidylinositol (gpi)-anchor biosynthesis R07129 +R07767 1 YOR196C protein N6-(octanoyl)lysine:sulfur sulfurtransferase 2.8.1.8 sce00785 lipoic acid metabolism R07767 +R07768 1 YOR196C octanoyl-[acp]:sulfur sulfurtransferase 2.8.1.8 sce00785 lipoic acid metabolism R07768 +RXN-14381 0 ( YOR226C or YPL135W ) Iron sulfur cluster assembly protein 2, mitochondrial (Iron sulfur cluster scaffold protein 2) iron-sulfur cluster biosynthesis +R01931 1 ( YOR251C or YOR285W or YOR286W ) thiosulfate:cyanide sulfurtranserase 2.8.1.1;2.8.1.- sce00920 sulfur metabolism R01931 +MNXR101505 1 ( YOR334W or YPL060W ) Magnesium transporter MRS2, mitochondrial (RNA-splicing protein MRS2) magnesium transport +R01005 1 YPL227C UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase 2.4.1.117 sce00510 n-glycan biosynthesis R01005 +MNXR104466 1 YPR003C Putative sulfate transporter YPR003C sulfate transport +R01708 1 YPR127W Pyridoxine:NADP+ 4-oxidoreductase 1.1.1.65 sce00750 vitamin b6 metabolism R01708 +R01206 1 ( YDR371W or YLR286C ) [1,4-(N-Acetyl-beta-D-glucosaminyl)]n glycanohydrolase 3.2.1.14 sce00520 amino sugar and nucleotide sugar metabolism R01206 +MNXR96691 1 YOR161C Protein PNS1 (pH nine-sensitive protein 1) choline transport +R03042 1 ( YHR201C or YDR452W ) Polyphosphate phosphohydrolase 3.6.1.10; 3.6.1.-; 3.6.1.11 cofactor and prosthetic group biosynthesis R03042 +MNXR96952 0 YDR270W Copper-transporting ATPase (EC 3.6.3.54) (Cu(2+)-ATPase) 3.6.3.54 cu2+ transport +RXN-14214 0 YDR452W Endopolyphosphatase (EC 3.6.1.10) (Deoxyadenosine triphosphate phosphohydrolase) (dATP phosphohydrolase) (EC 3.6.1.-) (Exopolyphosphatase) (EC 3.6.1.11) (Phosphate metabolism protein 5) 3.6.1.10; 3.6.1.-; 3.6.1.11 other +R03804 1 YLR351C Monoamide of a dicarboxylic acid amidohydrolase 3.5.1.3 other R03804 +MNXR124629 1 YMR301C Iron-sulfur clusters transporter ATM1, mitochondrial porphyrin transport +R06199 1 YOL157C Oligo-1,6-glucosidase IMA2 (EC 3.2.1.10) (Alpha-glucosidase) (Isomaltase 2) 3.2.1.10 sce00500 starch and sucrose metabolism R06199 +MNXR99010 1 YEL004W UDP-N-acetylglucosamine transporter YEA4 uridine diphosphate-n-acetylglucosamine (udp-glcnac) transport diff --git a/ComplementaryData/modelCuration/GapfillingnewRxnMatrix.tsv b/ComplementaryData/modelCuration/GapfillingnewRxnMatrix.tsv index a520ebc7..3021b522 100644 --- a/ComplementaryData/modelCuration/GapfillingnewRxnMatrix.tsv +++ b/ComplementaryData/modelCuration/GapfillingnewRxnMatrix.tsv @@ -1,76 +1,76 @@ -ID coefficient standard_name type compartment -MNXR94845 1 H+ reactant cytoplasm -MNXR94845 1 3-(4-hydroxyphenyl)pyruvate reactant cytoplasm -MNXR94845 1 H+ product peroxisome -MNXR94845 1 3-(4-hydroxyphenyl)pyruvate product peroxisome -MNXR95431 1 acetate reactant cytoplasm -MNXR95431 1 acetate product endoplasmic reticulum -MNXR95481 1 ADP-ribose reactant cytoplasm -MNXR95481 1 ADP-ribose product nucleus -MNXR99646 1 farnesyl diphosphate reactant cytoplasm -MNXR99646 1 farnesyl diphosphate product lipid particle -MNXR101858 1 H+ reactant cytoplasm -MNXR101858 1 nicotinate reactant cytoplasm -MNXR101858 1 H+ product mitochondrion -MNXR101858 1 nicotinate product mitochondrion -MNXR135002 1 H+ reactant cytoplasm -MNXR135002 1 O-phosphoethanolamine reactant cytoplasm -MNXR135002 1 H+ product endoplasmic reticulum -MNXR135002 1 O-phosphoethanolamine product endoplasmic reticulum -MNXR102871 1 phosphate reactant cytoplasm -MNXR102871 1 phosphate product Golgi -MNXR106312 1 H2O reactant cytoplasm -MNXR106312 1 ATP reactant cytoplasm -MNXR106312 1 propionyl-CoA reactant cytoplasm -MNXR106312 1 H+ product mitochondrion -MNXR106312 1 ADP product mitochondrion -MNXR106312 1 propionyl-CoA product mitochondrion -MNXR106312 1 phosphate product mitochondrion -MNXR105076 1 UDP reactant cytoplasm -MNXR105076 1 UDP product Golgi -MNXR105076_2 1 UDP reactant cytoplasm -MNXR105076_2 1 UDP product nucleus -MNXR105127 1 UMP reactant cytoplasm -MNXR105127 1 UMP product Golgi -MNXR104921 1 TRX1 disulphide reactant cytoplasm -MNXR104921 1 TRX1 disulphide product nucleus -MNXR99110 1 oleate reactant cytoplasm -MNXR99110 1 oleate product mitochondrion -MNXR95426 1 H+ reactant cytoplasm -MNXR95426 1 (R)-acetoin reactant cytoplasm -MNXR95426 1 H+ product nucleus -MNXR95426 1 (R)-acetoin product nucleus -MNXR100259 1 L-glutamine reactant cytoplasm -MNXR100259 1 L-glutamine product mitochondrion -MNXR105127_2 1 UMP reactant cytoplasm -MNXR105127_2 1 UMP product endoplasmic reticulum -MNXR95809 1 S-adenosyl-L-methionine reactant cytoplasm -MNXR95809 1 S-adenosyl-L-methionine product nucleus -MNXR100449 1 glutathione reactant cytoplasm -MNXR100449 1 glutathione product endoplasmic reticulum -MNXR96123 1 ATP reactant cytoplasm -MNXR96123 1 ADP reactant vacuole -MNXR96123 1 ATP product vacuole -MNXR96123 1 ADP product cytoplasm -MNXR101385 1 D-mannose 6-phosphate reactant cytoplasm -MNXR101385 1 D-mannose 6-phosphate product vacuole -MNXR95416 1 O-acetyl-L-serine reactant cytoplasm -MNXR95416 1 O-acetyl-L-serine product mitochondrion -MNXR100494 1 hydrogen sulfide reactant cytoplasm -MNXR100494 1 hydrogen sulfide product mitochondrion -MNXR97002 1 H+ reactant cytoplasm -MNXR97002 1 L-cysteinylglycine reactant cytoplasm -MNXR97002 1 H+ product mitochondrion -MNXR97002 1 L-cysteinylglycine product mitochondrion -MNXR96123_2 1 ATP reactant cytoplasm -MNXR96123_2 1 ADP reactant endoplasmic reticulum membrane -MNXR96123_2 1 ATP product endoplasmic reticulum membrane -MNXR96123_2 1 ADP product cytoplasm -MNXR104966 1 thiosulfate reactant cytoplasm -MNXR104966 1 thiosulfate product mitochondrion -MNXR104460 1 sulphite reactant cytoplasm -MNXR104460 1 sulphite product mitochondrion -MNXR105071 1 UDP-D-glucose reactant cytoplasm -MNXR105071 1 UDP-D-glucose product endoplasmic reticulum -MNXR105021 1 UDP-N-acetyl-alpha-D-glucosamine reactant cytoplasm -MNXR105021 1 UDP-N-acetyl-alpha-D-glucosamine product Golgi +ID coefficient standard_name type compartment +MNXR94845 1 H+ reactant cytoplasm +MNXR94845 1 3-(4-hydroxyphenyl)pyruvate reactant cytoplasm +MNXR94845 1 H+ product peroxisome +MNXR94845 1 3-(4-hydroxyphenyl)pyruvate product peroxisome +MNXR95431 1 acetate reactant cytoplasm +MNXR95431 1 acetate product endoplasmic reticulum +MNXR95481 1 ADP-ribose reactant cytoplasm +MNXR95481 1 ADP-ribose product nucleus +MNXR99646 1 farnesyl diphosphate reactant cytoplasm +MNXR99646 1 farnesyl diphosphate product lipid particle +MNXR101858 1 H+ reactant cytoplasm +MNXR101858 1 nicotinate reactant cytoplasm +MNXR101858 1 H+ product mitochondrion +MNXR101858 1 nicotinate product mitochondrion +MNXR135002 1 H+ reactant cytoplasm +MNXR135002 1 O-phosphoethanolamine reactant cytoplasm +MNXR135002 1 H+ product endoplasmic reticulum +MNXR135002 1 O-phosphoethanolamine product endoplasmic reticulum +MNXR102871 1 phosphate reactant cytoplasm +MNXR102871 1 phosphate product Golgi +MNXR106312 1 H2O reactant cytoplasm +MNXR106312 1 ATP reactant cytoplasm +MNXR106312 1 propionyl-CoA reactant cytoplasm +MNXR106312 1 H+ product mitochondrion +MNXR106312 1 ADP product mitochondrion +MNXR106312 1 propionyl-CoA product mitochondrion +MNXR106312 1 phosphate product mitochondrion +MNXR105076 1 UDP reactant cytoplasm +MNXR105076 1 UDP product Golgi +MNXR105076_2 1 UDP reactant cytoplasm +MNXR105076_2 1 UDP product nucleus +MNXR105127 1 UMP reactant cytoplasm +MNXR105127 1 UMP product Golgi +MNXR104921 1 TRX1 disulphide reactant cytoplasm +MNXR104921 1 TRX1 disulphide product nucleus +MNXR99110 1 oleate reactant cytoplasm +MNXR99110 1 oleate product mitochondrion +MNXR95426 1 H+ reactant cytoplasm +MNXR95426 1 (R)-acetoin reactant cytoplasm +MNXR95426 1 H+ product nucleus +MNXR95426 1 (R)-acetoin product nucleus +MNXR100259 1 L-glutamine reactant cytoplasm +MNXR100259 1 L-glutamine product mitochondrion +MNXR105127_2 1 UMP reactant cytoplasm +MNXR105127_2 1 UMP product endoplasmic reticulum +MNXR95809 1 S-adenosyl-L-methionine reactant cytoplasm +MNXR95809 1 S-adenosyl-L-methionine product nucleus +MNXR100449 1 glutathione reactant cytoplasm +MNXR100449 1 glutathione product endoplasmic reticulum +MNXR96123 1 ATP reactant cytoplasm +MNXR96123 1 ADP reactant vacuole +MNXR96123 1 ATP product vacuole +MNXR96123 1 ADP product cytoplasm +MNXR101385 1 D-mannose 6-phosphate reactant cytoplasm +MNXR101385 1 D-mannose 6-phosphate product vacuole +MNXR95416 1 O-acetyl-L-serine reactant cytoplasm +MNXR95416 1 O-acetyl-L-serine product mitochondrion +MNXR100494 1 hydrogen sulfide reactant cytoplasm +MNXR100494 1 hydrogen sulfide product mitochondrion +MNXR97002 1 H+ reactant cytoplasm +MNXR97002 1 L-cysteinylglycine reactant cytoplasm +MNXR97002 1 H+ product mitochondrion +MNXR97002 1 L-cysteinylglycine product mitochondrion +MNXR96123_2 1 ATP reactant cytoplasm +MNXR96123_2 1 ADP reactant endoplasmic reticulum membrane +MNXR96123_2 1 ATP product endoplasmic reticulum membrane +MNXR96123_2 1 ADP product cytoplasm +MNXR104966 1 thiosulfate reactant cytoplasm +MNXR104966 1 thiosulfate product mitochondrion +MNXR104460 1 sulphite reactant cytoplasm +MNXR104460 1 sulphite product mitochondrion +MNXR105071 1 UDP-D-glucose reactant cytoplasm +MNXR105071 1 UDP-D-glucose product endoplasmic reticulum +MNXR105021 1 UDP-N-acetyl-alpha-D-glucosamine reactant cytoplasm +MNXR105021 1 UDP-N-acetyl-alpha-D-glucosamine product Golgi diff --git a/ComplementaryData/modelCuration/GapfillingnewRxnProp.tsv b/ComplementaryData/modelCuration/GapfillingnewRxnProp.tsv index fb82a6f3..89dbcca3 100644 --- a/ComplementaryData/modelCuration/GapfillingnewRxnProp.tsv +++ b/ComplementaryData/modelCuration/GapfillingnewRxnProp.tsv @@ -1,29 +1,29 @@ -rxnID rev GPR standard_name EC rxnID_kegg rxnID_MNX Source;reason -MNXR94845 1 3-(4-hydroxyphenyl)pyruvate transport MNXR94845 seed:rxn09802; unknown transporter -MNXR95431 1 acetate transport MNXR95431 rhea:27814; unknown transporter -MNXR95481 1 ADP-ribose transport MNXR95481 bigg:ADPRIBt; unknown transporter -MNXR99646 1 farnesyl diphosphate transport MNXR99646 seed:rxn13290; unknown transporter -MNXR101858 1 nicotinate transport MNXR101858 seed:rxn12806; unknown transporter -MNXR135002 1 O-phosphoethanolamine transport MNXR135002 seed:rxn05716; unknown transporter -MNXR102871 1 phosphate transport MNXR102871 rhea:32823; bigg:PItg; unknown transporter -MNXR106312 0 propionyl-CoA transport MNXR106312 bigg:r2499; unknown transporter -MNXR105076 1 UDP transport MNXR105076 bigg:UDPtg; unknown transporter -MNXR105076_2 1 UDP transport MNXR105076 bigg:UDPtg; unknown transporter -MNXR105127 1 UMP transport MNXR105127 rhea:27926; unknown transporter -MNXR104921 1 TRX1 disulphide transport MNXR104921 seed:rxn13406; unknown transporter -MNXR99110 1 oleate transport MNXR99110 rhea:33655; unknown transporter -MNXR95426 1 (R)-acetoin transport MNXR95426 bigg:ACTNt2r; unknown transporter -MNXR100259 1 L-glutamine transport MNXR100259 seed:rxn08625; bigg:GLNtm; unknown transporter -MNXR105127_2 1 UMP transport MNXR105127 rhea:27926; unknown transporter -MNXR95809 1 S-adenosyl-L-methionine transport MNXR95809 seed:rxn09784; bigg:AMETtn; unknown transporter -MNXR100449 1 glutathione transport MNXR100449 seed:rxn08677; unknown transporter -MNXR96123 1 ATP transport 2.7.4.6 MNXR96123 rhea:34999; unknown transporter -MNXR101385 1 D-mannose 6-phosphate transport MNXR101385 seed:rxn08880; unknown transporter -MNXR95416 1 O-acetyl-L-serine transport MNXR95416 rhea:29659; bigg:ACSERtmi; unknown transporter -MNXR100494 1 hydrogen sulfide transport MNXR100494 seed:rxn08689; unknown transporter -MNXR97002 1 L-cysteinylglycine transport MNXR97002 seed:rxn05529; unknown transporter -MNXR96123_2 1 ATP transport 2.7.4.6 MNXR96123 rhea:34999; unknown transporter -MNXR104966 1 thiosulfate transport MNXR104966 rhea:32807; unknown transporter -MNXR104460 1 sulphite transport MNXR104460 seed:rxn09260; unknown transporter -MNXR105071 1 UDP-D-glucose transport MNXR105071 seed:rxn09353; unknown transporter -MNXR105021 1 UDP-N-acetyl-alpha-D-glucosamine transport MNXR105021 seed:rxn09342; unknown transporter +rxnID rev GPR standard_name EC rxnID_kegg rxnID_MNX Source;reason +MNXR94845 1 3-(4-hydroxyphenyl)pyruvate transport MNXR94845 seed:rxn09802; unknown transporter +MNXR95431 1 acetate transport MNXR95431 rhea:27814; unknown transporter +MNXR95481 1 ADP-ribose transport MNXR95481 bigg:ADPRIBt; unknown transporter +MNXR99646 1 farnesyl diphosphate transport MNXR99646 seed:rxn13290; unknown transporter +MNXR101858 1 nicotinate transport MNXR101858 seed:rxn12806; unknown transporter +MNXR135002 1 O-phosphoethanolamine transport MNXR135002 seed:rxn05716; unknown transporter +MNXR102871 1 phosphate transport MNXR102871 rhea:32823; bigg:PItg; unknown transporter +MNXR106312 0 propionyl-CoA transport MNXR106312 bigg:r2499; unknown transporter +MNXR105076 1 UDP transport MNXR105076 bigg:UDPtg; unknown transporter +MNXR105076_2 1 UDP transport MNXR105076 bigg:UDPtg; unknown transporter +MNXR105127 1 UMP transport MNXR105127 rhea:27926; unknown transporter +MNXR104921 1 TRX1 disulphide transport MNXR104921 seed:rxn13406; unknown transporter +MNXR99110 1 oleate transport MNXR99110 rhea:33655; unknown transporter +MNXR95426 1 (R)-acetoin transport MNXR95426 bigg:ACTNt2r; unknown transporter +MNXR100259 1 L-glutamine transport MNXR100259 seed:rxn08625; bigg:GLNtm; unknown transporter +MNXR105127_2 1 UMP transport MNXR105127 rhea:27926; unknown transporter +MNXR95809 1 S-adenosyl-L-methionine transport MNXR95809 seed:rxn09784; bigg:AMETtn; unknown transporter +MNXR100449 1 glutathione transport MNXR100449 seed:rxn08677; unknown transporter +MNXR96123 1 ATP transport 2.7.4.6 MNXR96123 rhea:34999; unknown transporter +MNXR101385 1 D-mannose 6-phosphate transport MNXR101385 seed:rxn08880; unknown transporter +MNXR95416 1 O-acetyl-L-serine transport MNXR95416 rhea:29659; bigg:ACSERtmi; unknown transporter +MNXR100494 1 hydrogen sulfide transport MNXR100494 seed:rxn08689; unknown transporter +MNXR97002 1 L-cysteinylglycine transport MNXR97002 seed:rxn05529; unknown transporter +MNXR96123_2 1 ATP transport 2.7.4.6 MNXR96123 rhea:34999; unknown transporter +MNXR104966 1 thiosulfate transport MNXR104966 rhea:32807; unknown transporter +MNXR104460 1 sulphite transport MNXR104460 seed:rxn09260; unknown transporter +MNXR105071 1 UDP-D-glucose transport MNXR105071 seed:rxn09353; unknown transporter +MNXR105021 1 UDP-N-acetyl-alpha-D-glucosamine transport MNXR105021 seed:rxn09342; unknown transporter diff --git a/ComplementaryData/modelCuration/Metabolomics_newRxnMatrix.tsv b/ComplementaryData/modelCuration/Metabolomics_newRxnMatrix.tsv index 05a0265e..30ef70ab 100644 --- a/ComplementaryData/modelCuration/Metabolomics_newRxnMatrix.tsv +++ b/ComplementaryData/modelCuration/Metabolomics_newRxnMatrix.tsv @@ -1,96 +1,96 @@ -ID coefficient standard_name type compartment -MNXR111769 1 2-hydroxyglutarate reactant cytoplasm -MNXR111769 1 NAD reactant cytoplasm -MNXR111769 1 H+ product cytoplasm -MNXR111769 1 NADH product cytoplasm -MNXR111769 1 2-oxoglutarate product cytoplasm -MNXR134240 1 2-hydroxyglutarate reactant cytoplasm -MNXR134240 3 H+ product cytoplasm -MNXR134240 1 glyoxylate product cytoplasm -MNXR134240 1 propionyl-CoA product cytoplasm -MNXR95862 1 beta-alanine reactant cytoplasm -MNXR95862 1 2-oxoglutarate reactant cytoplasm -MNXR95862 1 3-oxopropanoate product cytoplasm -MNXR95862 1 L-glutamate product cytoplasm -MNXR101665 1 coenzyme A reactant cytoplasm -MNXR101665 1 3-oxopropanoate reactant cytoplasm -MNXR101665 1 NAD reactant cytoplasm -MNXR101665 1 NADH product cytoplasm -MNXR101665 1 carbon dioxide product cytoplasm -MNXR101665 1 acetyl-CoA product cytoplasm -MNXR106650 1 coenzyme A reactant cytoplasm -MNXR106650 1 3-oxopropanoate reactant cytoplasm -MNXR106650 1 NADP(+) reactant cytoplasm -MNXR106650 1 carbon dioxide product cytoplasm -MNXR106650 1 acetyl-CoA product cytoplasm -MNXR106650 1 NADPH product cytoplasm -MNXR110693 1 H+ reactant cytoplasm -MNXR110693 1 3-oxopropanoate reactant cytoplasm -MNXR110693 1 carbon dioxide product cytoplasm -MNXR110693 1 acetaldehyde product cytoplasm -MNXR100904 1 (R)-2,3-dihydroxy-3-methylbutanoate reactant cytoplasm -MNXR100904 1 NADP(+) reactant cytoplasm -MNXR100904 1 H+ product cytoplasm -MNXR100904 1 3-hydroxy-3-methyl-2-oxobutanoate product cytoplasm -MNXR100904 1 NADPH product cytoplasm -MNXR137278 1 3-methyl-2-oxobutanoate reactant cytoplasm -MNXR137278 1 3-hydroxy-3-methyl-2-oxobutanoate product cytoplasm -MNXR137279 1 2-acetyllactic acid reactant cytoplasm -MNXR137279 1 NADPH reactant cytoplasm -MNXR137279 1 H+ product cytoplasm -MNXR137279 1 3-hydroxy-3-methyl-2-oxobutanoate product cytoplasm -MNXR137279 1 NADP(+) product cytoplasm -MNXR95271 1 H+ reactant cytoplasm -MNXR95271 2 pyruvate reactant cytoplasm -MNXR95271 1 (2S)-2-acetolactate product cytoplasm -MNXR95271 1 carbon dioxide product cytoplasm -MNXR100390 1 H+ reactant cytoplasm -MNXR100390 1 6-phospho-D-gluconate reactant cytoplasm -MNXR100390 1 ADP reactant cytoplasm -MNXR100390 1 ATP product cytoplasm -MNXR100390 1 D-gluconate product cytoplasm -MNXR97523 1 (R)-2,3-dihydroxy-3-methylbutanoate reactant cytoplasm -MNXR97523 1 NADP(+) reactant cytoplasm -MNXR97523 1 H+ product cytoplasm -MNXR97523 1 (2S)-2-acetolactate product cytoplasm -MNXR97523 1 NADPH product cytoplasm -MNXR106779 1 (2R,3S)-3-methylmalate reactant cytoplasm -MNXR106779 1 NAD reactant cytoplasm -MNXR106779 1 NADH product cytoplasm -MNXR106779 1 carbon dioxide product cytoplasm -MNXR106779 1 2-oxobutanoate product cytoplasm -MNXR121603 1 H2O reactant cytoplasm -MNXR121603 1 glyoxylate reactant cytoplasm -MNXR121603 1 propionyl-CoA reactant cytoplasm -MNXR121603 1 H+ product cytoplasm -MNXR121603 1 coenzyme A product cytoplasm -MNXR121603 1 (2R,3S)-3-methylmalate product cytoplasm -MNXR99136 1 H2O reactant cytoplasm -MNXR99136 1 trans-2,cis-9-octadecadienoyl-CoA reactant cytoplasm -MNXR99136 1 H+ product cytoplasm -MNXR99136 1 coenzyme A product cytoplasm -MNXR99136 1 (9Z,12Z)-octadecadienoate product cytoplasm -MNXR99175 1 coenzyme A reactant cytoplasm -MNXR99175 1 (9Z,12Z)-octadecadienoate reactant cytoplasm -MNXR99175 1 ATP reactant cytoplasm -MNXR99175 1 diphosphate product cytoplasm -MNXR99175 1 AMP product cytoplasm -MNXR99175 1 trans-2,cis-9-octadecadienoyl-CoA product cytoplasm -MNXR100010 1 stachyose reactant cytoplasm -MNXR100010 1 H2O reactant cytoplasm -MNXR100010 1 D-galactose product cytoplasm -MNXR100010 1 raffinose product cytoplasm -MNXR122225 2 raffinose product cytoplasm -MNXR122225 1 stachyose reactant cytoplasm -MNXR122225 1 sucrose reactant cytoplasm -MNXR123213 1 6-phospho-D-gluconate reactant cytoplasm -MNXR123213 1 D-gluconate product cytoplasm -MNXR123213 1 phosphate product cytoplasm -MNXR110535 1 H+ reactant cytoplasm -MNXR110535 1 phenylacetic acid reactant cytoplasm -MNXR110535 1 4-hydroxyphenyl acetate product cytoplasm -MNXR110621 1 H+ reactant cytoplasm -MNXR110621 1 acetate reactant cytoplasm -MNXR110621 1 Hydroquinone reactant cytoplasm -MNXR110621 1 H2O product cytoplasm -MNXR110621 1 4-hydroxyphenyl acetate product cytoplasm +ID coefficient standard_name type compartment +MNXR111769 1 2-hydroxyglutarate reactant cytoplasm +MNXR111769 1 NAD reactant cytoplasm +MNXR111769 1 H+ product cytoplasm +MNXR111769 1 NADH product cytoplasm +MNXR111769 1 2-oxoglutarate product cytoplasm +MNXR134240 1 2-hydroxyglutarate reactant cytoplasm +MNXR134240 3 H+ product cytoplasm +MNXR134240 1 glyoxylate product cytoplasm +MNXR134240 1 propionyl-CoA product cytoplasm +MNXR95862 1 beta-alanine reactant cytoplasm +MNXR95862 1 2-oxoglutarate reactant cytoplasm +MNXR95862 1 3-oxopropanoate product cytoplasm +MNXR95862 1 L-glutamate product cytoplasm +MNXR101665 1 coenzyme A reactant cytoplasm +MNXR101665 1 3-oxopropanoate reactant cytoplasm +MNXR101665 1 NAD reactant cytoplasm +MNXR101665 1 NADH product cytoplasm +MNXR101665 1 carbon dioxide product cytoplasm +MNXR101665 1 acetyl-CoA product cytoplasm +MNXR106650 1 coenzyme A reactant cytoplasm +MNXR106650 1 3-oxopropanoate reactant cytoplasm +MNXR106650 1 NADP(+) reactant cytoplasm +MNXR106650 1 carbon dioxide product cytoplasm +MNXR106650 1 acetyl-CoA product cytoplasm +MNXR106650 1 NADPH product cytoplasm +MNXR110693 1 H+ reactant cytoplasm +MNXR110693 1 3-oxopropanoate reactant cytoplasm +MNXR110693 1 carbon dioxide product cytoplasm +MNXR110693 1 acetaldehyde product cytoplasm +MNXR100904 1 (R)-2,3-dihydroxy-3-methylbutanoate reactant cytoplasm +MNXR100904 1 NADP(+) reactant cytoplasm +MNXR100904 1 H+ product cytoplasm +MNXR100904 1 3-hydroxy-3-methyl-2-oxobutanoate product cytoplasm +MNXR100904 1 NADPH product cytoplasm +MNXR137278 1 3-methyl-2-oxobutanoate reactant cytoplasm +MNXR137278 1 3-hydroxy-3-methyl-2-oxobutanoate product cytoplasm +MNXR137279 1 2-acetyllactic acid reactant cytoplasm +MNXR137279 1 NADPH reactant cytoplasm +MNXR137279 1 H+ product cytoplasm +MNXR137279 1 3-hydroxy-3-methyl-2-oxobutanoate product cytoplasm +MNXR137279 1 NADP(+) product cytoplasm +MNXR95271 1 H+ reactant cytoplasm +MNXR95271 2 pyruvate reactant cytoplasm +MNXR95271 1 (2S)-2-acetolactate product cytoplasm +MNXR95271 1 carbon dioxide product cytoplasm +MNXR100390 1 H+ reactant cytoplasm +MNXR100390 1 6-phospho-D-gluconate reactant cytoplasm +MNXR100390 1 ADP reactant cytoplasm +MNXR100390 1 ATP product cytoplasm +MNXR100390 1 D-gluconate product cytoplasm +MNXR97523 1 (R)-2,3-dihydroxy-3-methylbutanoate reactant cytoplasm +MNXR97523 1 NADP(+) reactant cytoplasm +MNXR97523 1 H+ product cytoplasm +MNXR97523 1 (2S)-2-acetolactate product cytoplasm +MNXR97523 1 NADPH product cytoplasm +MNXR106779 1 (2R,3S)-3-methylmalate reactant cytoplasm +MNXR106779 1 NAD reactant cytoplasm +MNXR106779 1 NADH product cytoplasm +MNXR106779 1 carbon dioxide product cytoplasm +MNXR106779 1 2-oxobutanoate product cytoplasm +MNXR121603 1 H2O reactant cytoplasm +MNXR121603 1 glyoxylate reactant cytoplasm +MNXR121603 1 propionyl-CoA reactant cytoplasm +MNXR121603 1 H+ product cytoplasm +MNXR121603 1 coenzyme A product cytoplasm +MNXR121603 1 (2R,3S)-3-methylmalate product cytoplasm +MNXR99136 1 H2O reactant cytoplasm +MNXR99136 1 trans-2,cis-9-octadecadienoyl-CoA reactant cytoplasm +MNXR99136 1 H+ product cytoplasm +MNXR99136 1 coenzyme A product cytoplasm +MNXR99136 1 (9Z,12Z)-octadecadienoate product cytoplasm +MNXR99175 1 coenzyme A reactant cytoplasm +MNXR99175 1 (9Z,12Z)-octadecadienoate reactant cytoplasm +MNXR99175 1 ATP reactant cytoplasm +MNXR99175 1 diphosphate product cytoplasm +MNXR99175 1 AMP product cytoplasm +MNXR99175 1 trans-2,cis-9-octadecadienoyl-CoA product cytoplasm +MNXR100010 1 stachyose reactant cytoplasm +MNXR100010 1 H2O reactant cytoplasm +MNXR100010 1 D-galactose product cytoplasm +MNXR100010 1 raffinose product cytoplasm +MNXR122225 2 raffinose product cytoplasm +MNXR122225 1 stachyose reactant cytoplasm +MNXR122225 1 sucrose reactant cytoplasm +MNXR123213 1 6-phospho-D-gluconate reactant cytoplasm +MNXR123213 1 D-gluconate product cytoplasm +MNXR123213 1 phosphate product cytoplasm +MNXR110535 1 H+ reactant cytoplasm +MNXR110535 1 phenylacetic acid reactant cytoplasm +MNXR110535 1 4-hydroxyphenyl acetate product cytoplasm +MNXR110621 1 H+ reactant cytoplasm +MNXR110621 1 acetate reactant cytoplasm +MNXR110621 1 Hydroquinone reactant cytoplasm +MNXR110621 1 H2O product cytoplasm +MNXR110621 1 4-hydroxyphenyl acetate product cytoplasm diff --git a/ComplementaryData/modelCuration/Metabolomics_newRxnMetAnnotation.tsv b/ComplementaryData/modelCuration/Metabolomics_newRxnMetAnnotation.tsv index 9251889c..58eaf132 100644 --- a/ComplementaryData/modelCuration/Metabolomics_newRxnMetAnnotation.tsv +++ b/ComplementaryData/modelCuration/Metabolomics_newRxnMetAnnotation.tsv @@ -1,15 +1,15 @@ -NewMetName Charged formula Charge compartment KEGG ID CHEBI ID Remark Ref -2-hydroxyglutarate [cytoplasm] C5H6O5 -2 cytoplasm C02630 CHEBI:11596 MNXM1210 DOI: 10.1002/biot.201500613; DOI: 10.1021/ac302881e; DOI: 10.1186/jbiol54 -propionyl-CoA [cytoplasm] C24H36N7O17P3S -4 cytoplasm C00100 CHEBI:57392 MNXM86 exist in model, but in another compartment -3-oxopropanoate [cytoplasm] C3H3O3 -1 cytoplasm C00222 CHEBI:33190 MNXM244 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x -(R)-2,3-dihydroxy-3-methylbutanoate [cytoplasm] C5H9O4 -1 cytoplasm C04272 CHEBI:49072 MNXM114097 exist in model, but in another compartment -3-hydroxy-3-methyl-2-oxobutanoate [cytoplasm] C5H7O4 -1 cytoplasm C04181 CHEBI:11812 MNXM1638 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x -2-acetyllactic acid [cytoplasm] C5H7O4 -1 cytoplasm C00900 CHEBI:57774 MNXM426 exist in model, but in another compartment -(2S)-2-acetolactate [cytoplasm] C5H7O4 -1 cytoplasm C06010 CHEBI:58476 MNXM114079 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x -(2R,3S)-3-methylmalate [cytoplasm] C5H6O5 -2 cytoplasm C06032 CHEBI:58511 MNXM2512 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x -trans-2,cis-9-octadecadienoyl-CoA [cytoplasm] C39H62N7O17P3S -4 cytoplasm C02050 CHEBI:57383 MNXM638 exist in model, but in another compartment -(9Z,12Z)-octadecadienoate [cytoplasm] C18H31O2 -1 cytoplasm C01595 CHEBI:30245 MNXM293 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x; DOI: 10.1016/j.procbio.2017.04.003; DOI: 10.1038/srep42659 -stachyose [cytoplasm] C24H42O21 0 cytoplasm C01613 CHEBI:17164 MNXM1503 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x -raffinose [cytoplasm] C18H32O16 0 cytoplasm C00492 CHEBI:16634 MNXM621 exist in model, but in another compartment -4-hydroxyphenyl acetate [cytoplasm] C8H8O3 0 cytoplasm C00642 CHEBI:18101 MNXM3863 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x -Hydroquinone [cytoplasm] C6H6O2 0 cytoplasm C00530 CHEBI:17594 MNXM376 exist in model, but in another compartment +NewMetName Charged formula Charge compartment KEGG ID CHEBI ID Remark Ref +2-hydroxyglutarate [cytoplasm] C5H6O5 -2 cytoplasm C02630 CHEBI:11596 MNXM1210 DOI: 10.1002/biot.201500613; DOI: 10.1021/ac302881e; DOI: 10.1186/jbiol54 +propionyl-CoA [cytoplasm] C24H36N7O17P3S -4 cytoplasm C00100 CHEBI:57392 MNXM86 exist in model, but in another compartment +3-oxopropanoate [cytoplasm] C3H3O3 -1 cytoplasm C00222 CHEBI:33190 MNXM244 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x +(R)-2,3-dihydroxy-3-methylbutanoate [cytoplasm] C5H9O4 -1 cytoplasm C04272 CHEBI:49072 MNXM114097 exist in model, but in another compartment +3-hydroxy-3-methyl-2-oxobutanoate [cytoplasm] C5H7O4 -1 cytoplasm C04181 CHEBI:11812 MNXM1638 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x +2-acetyllactic acid [cytoplasm] C5H7O4 -1 cytoplasm C00900 CHEBI:57774 MNXM426 exist in model, but in another compartment +(2S)-2-acetolactate [cytoplasm] C5H7O4 -1 cytoplasm C06010 CHEBI:58476 MNXM114079 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x +(2R,3S)-3-methylmalate [cytoplasm] C5H6O5 -2 cytoplasm C06032 CHEBI:58511 MNXM2512 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x +trans-2,cis-9-octadecadienoyl-CoA [cytoplasm] C39H62N7O17P3S -4 cytoplasm C02050 CHEBI:57383 MNXM638 exist in model, but in another compartment +(9Z,12Z)-octadecadienoate [cytoplasm] C18H31O2 -1 cytoplasm C01595 CHEBI:30245 MNXM293 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x; DOI: 10.1016/j.procbio.2017.04.003; DOI: 10.1038/srep42659 +stachyose [cytoplasm] C24H42O21 0 cytoplasm C01613 CHEBI:17164 MNXM1503 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x +raffinose [cytoplasm] C18H32O16 0 cytoplasm C00492 CHEBI:16634 MNXM621 exist in model, but in another compartment +4-hydroxyphenyl acetate [cytoplasm] C8H8O3 0 cytoplasm C00642 CHEBI:18101 MNXM3863 DOI: 10.1186/s12918-016-0350-8; DOI: 10.1007/s11306-017-1195-x +Hydroquinone [cytoplasm] C6H6O2 0 cytoplasm C00530 CHEBI:17594 MNXM376 exist in model, but in another compartment diff --git a/ComplementaryData/modelCuration/Metabolomics_newRxnProp.tsv b/ComplementaryData/modelCuration/Metabolomics_newRxnProp.tsv index 5aa3a5e0..f14b88df 100644 --- a/ComplementaryData/modelCuration/Metabolomics_newRxnProp.tsv +++ b/ComplementaryData/modelCuration/Metabolomics_newRxnProp.tsv @@ -1,22 +1,22 @@ -RxnID rev RxnName EC rxnID_kegg Source -MNXR100390 0 ATP:D-Gluconate 6-phosphotransferase 2.7.1.12 R01737 rhea:19433 -MNXR123213 0 6-phosphogluconate phosphatase 3.1.3.-;3.1.3.2;3.1.3.29 metacyc:RXN0-5185 -MNXR110535 0 R06790 R06790 seed:rxn04605 -MNXR110621 0 Carboxylic ester hydrolases 3.1.1.-;3.1.1.2 rhea:47384 -MNXR111769 1 phosphoglycerate dehydrogenase 1.1.1.95 R08198 rhea:13449 -MNXR134240 1 seed:rxn00681 seed:rxn00681 -MNXR95862 1 beta-alanine:2-oxoglutarate aminotransferase 2.6.1.19;2.6.1.55 R00908 rhea:30699 -MNXR101665 0 3-Oxopropanoate:NAD+ oxidoreductase (decarboxylating, CoA-acetylating) 1.2.1.-;1.2.1.18;1.2.1.27 R00705 rhea:22992 -MNXR106650 0 3-Oxopropanoate:NADP+ oxidoreductase (decarboxylating, CoA-acetylating) 1.2.1.-;1.2.1.18 R00706 rhea:22988 -MNXR110693 0 3-oxopropanoate carboxy-lyase 4.1.1.-;4.2.1.155 R06973 rhea:45160 -MNXR100904 1 (R)-2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) 1.1.1.86 R04440 rhea:31139 -MNXR137278 0 Dihydroxy-acid dehydratase, mitochondrial seed:rxn13007 -MNXR137279 0 Ketol-acid reductoisomerase, mitochondrial seed:rxn13008 -MNXR95271 0 pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating) 2.2.1.6 R00226 rhea:25249 -MNXR97523 1 (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) 1.1.1.383;1.1.1.86 R04439 rhea:22068 -MNXR106779 0 (2R,3S)-3-methylmalate:NAD+ oxidoreductase 1.1.1.-;1.1.1.85 R00994 rhea:32715 -MNXR121603 0 malate/beta-methylmalate synthase 2.3.3.- metacyc:RXN-18333 -MNXR99136 0 palmitoyl-CoA hydrolase 3.1.2.-;3.1.2.2 rhea:40143 -MNXR99175 0 long-chain-fatty-acid---CoA ligase 6.2.1.3 rhea:33651 -MNXR100010 0 a-galactosidase (stachyose) 3.2.1.22 seed:rxn02596 -MNXR122225 0 stachyose synthase 2.4.1.- metacyc:RXN-8287 +RxnID rev RxnName EC rxnID_kegg Source +MNXR100390 0 ATP:D-Gluconate 6-phosphotransferase 2.7.1.12 R01737 rhea:19433 +MNXR123213 0 6-phosphogluconate phosphatase 3.1.3.-;3.1.3.2;3.1.3.29 metacyc:RXN0-5185 +MNXR110535 0 R06790 R06790 seed:rxn04605 +MNXR110621 0 Carboxylic ester hydrolases 3.1.1.-;3.1.1.2 rhea:47384 +MNXR111769 1 phosphoglycerate dehydrogenase 1.1.1.95 R08198 rhea:13449 +MNXR134240 1 seed:rxn00681 seed:rxn00681 +MNXR95862 1 beta-alanine:2-oxoglutarate aminotransferase 2.6.1.19;2.6.1.55 R00908 rhea:30699 +MNXR101665 0 3-Oxopropanoate:NAD+ oxidoreductase (decarboxylating, CoA-acetylating) 1.2.1.-;1.2.1.18;1.2.1.27 R00705 rhea:22992 +MNXR106650 0 3-Oxopropanoate:NADP+ oxidoreductase (decarboxylating, CoA-acetylating) 1.2.1.-;1.2.1.18 R00706 rhea:22988 +MNXR110693 0 3-oxopropanoate carboxy-lyase 4.1.1.-;4.2.1.155 R06973 rhea:45160 +MNXR100904 1 (R)-2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) 1.1.1.86 R04440 rhea:31139 +MNXR137278 0 Dihydroxy-acid dehydratase, mitochondrial seed:rxn13007 +MNXR137279 0 Ketol-acid reductoisomerase, mitochondrial seed:rxn13008 +MNXR95271 0 pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating) 2.2.1.6 R00226 rhea:25249 +MNXR97523 1 (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) 1.1.1.383;1.1.1.86 R04439 rhea:22068 +MNXR106779 0 (2R,3S)-3-methylmalate:NAD+ oxidoreductase 1.1.1.-;1.1.1.85 R00994 rhea:32715 +MNXR121603 0 malate/beta-methylmalate synthase 2.3.3.- metacyc:RXN-18333 +MNXR99136 0 palmitoyl-CoA hydrolase 3.1.2.-;3.1.2.2 rhea:40143 +MNXR99175 0 long-chain-fatty-acid---CoA ligase 6.2.1.3 rhea:33651 +MNXR100010 0 a-galactosidase (stachyose) 3.2.1.22 seed:rxn02596 +MNXR122225 0 stachyose synthase 2.4.1.- metacyc:RXN-8287 diff --git a/ComplementaryData/modelCuration/TransRxnNewGPR.tsv b/ComplementaryData/modelCuration/TransRxnNewGPR.tsv index 3e05d1c4..fa037801 100644 --- a/ComplementaryData/modelCuration/TransRxnNewGPR.tsv +++ b/ComplementaryData/modelCuration/TransRxnNewGPR.tsv @@ -1,102 +1,102 @@ -rxnID new_gpr -r_4468 ( YDR342C or YHR092C ) -r_1735 YBL042C -r_4493 YNL065W -r_4387 ( YJR152W or YKR093W ) -r_4398 ( YJR152W or YKR093W ) -r_4408 ( YJR152W or YKR093W ) -r_4473 ( YJR152W or YKR093W ) -r_4429 ( YJR152W or YKR093W ) -r_4471 ( YJR152W or YKR093W ) -r_4402 ( YJR152W or YKR093W ) -r_2190 YNL065W -r_1707 ( YDR342C or YHR092C ) -r_1717 ( YDL245C or YEL069C or YJR158W or YNR072W ) -r_2041 ( YDR342C or YHR092C ) -r_4395 ( YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W ) -r_1719 YHR092C -r_1149 YGL077C -r_1795 YNL065W -r_1990 YJL212C -r_4404 ( YJR152W or YKR093W ) -r_4424 ( YJR152W or YKR093W ) -r_4437 ( YJR152W or YKR093W ) -r_4361 ( YJR152W or YKR093W ) -r_1816 YNL065W -r_2191 YNL065W -r_1877 ( YDR342C or YHR092C ) -r_4469 YKR039W -r_1908 ( YDL245C or YEL069C or YJR158W or YNR072W ) -r_1910 ( YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W ) -r_4448 ( YJR152W or YKR093W ) -r_4457 YDR093W -r_2040 YOR306C -r_2105 ( YDL245C or YLL043W ) -r_1882 YOR100C -r_3607 YCR098C -r_1574 YKL120W -r_1642 YPR011C -r_1684 ( YGL077C or YOR161C ) -r_3959 YBR192W -r_3680 YHR002W -r_3960 YBR192W -r_1760 ( YIL013C or YOR011W ) -r_1803 YGL225W -r_2094 ( YLL052C or YPR192W ) -r_3526 ( YLL052C or YPR192W ) -r_3604 ( YLL052C or YLL053C or YPR192W ) -r_1179 ( YJL133W or YKR052C ) -r_1657 YBR147W -r_1658 YDR508C -r_1811 YPR058W -r_1837 YBR147W -r_1919 YBR147W -r_1935 YDR508C -r_1907 YKR039W -r_2045 YDR508C -r_3545 YKR039W -r_2072 YDR508C -r_1771 ( YKL188C and YPL147W ) -r_1772 ( YKL188C and YPL147W ) -r_1976 YOR100C -r_2231 ( YKL188C and YPL147W ) -r_1774 ( YKL188C and YPL147W ) -r_3961 ( YER053C or YJR077C or YLR348C ) -r_2008 YNR013C -r_3605 ( YCR037C or YJL198W or YML123C ) -r_3649 YNR013C -r_3893 YIL048W -r_3813 ( YIL048W or YMR162C ) -r_3897 YIL048W -r_3817 ( YIL048W or YMR162C ) -r_3894 YIL048W -r_3814 ( YIL048W or YMR162C ) -r_3898 YIL048W -r_3818 ( YIL048W or YMR162C ) -r_3895 YIL048W -r_3815 ( YIL048W or YMR162C ) -r_3899 YIL048W -r_3819 ( YIL048W or YMR162C ) -r_3896 YIL048W -r_3816 ( YIL048W or YMR162C ) -r_3900 YIL048W -r_3820 ( YIL048W or YMR162C ) -r_3821 YAL026C -r_3885 YAL026C -r_3825 YAL026C -r_3889 YAL026C -r_3822 YAL026C -r_3886 YAL026C -r_3826 YAL026C -r_3890 YAL026C -r_3823 YAL026C -r_3887 YAL026C -r_3827 YAL026C -r_3891 YAL026C -r_3824 YAL026C -r_3888 YAL026C -r_3828 YAL026C -r_3892 YAL026C -r_3606 YCR098C -r_1236 ( YKL188C and YPL147W ) -r_2107 ( YIL013C or YOR011W ) +rxnID new_gpr +r_4468 ( YDR342C or YHR092C ) +r_1735 YBL042C +r_4493 YNL065W +r_4387 ( YJR152W or YKR093W ) +r_4398 ( YJR152W or YKR093W ) +r_4408 ( YJR152W or YKR093W ) +r_4473 ( YJR152W or YKR093W ) +r_4429 ( YJR152W or YKR093W ) +r_4471 ( YJR152W or YKR093W ) +r_4402 ( YJR152W or YKR093W ) +r_2190 YNL065W +r_1707 ( YDR342C or YHR092C ) +r_1717 ( YDL245C or YEL069C or YJR158W or YNR072W ) +r_2041 ( YDR342C or YHR092C ) +r_4395 ( YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W ) +r_1719 YHR092C +r_1149 YGL077C +r_1795 YNL065W +r_1990 YJL212C +r_4404 ( YJR152W or YKR093W ) +r_4424 ( YJR152W or YKR093W ) +r_4437 ( YJR152W or YKR093W ) +r_4361 ( YJR152W or YKR093W ) +r_1816 YNL065W +r_2191 YNL065W +r_1877 ( YDR342C or YHR092C ) +r_4469 YKR039W +r_1908 ( YDL245C or YEL069C or YJR158W or YNR072W ) +r_1910 ( YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W ) +r_4448 ( YJR152W or YKR093W ) +r_4457 YDR093W +r_2040 YOR306C +r_2105 ( YDL245C or YLL043W ) +r_1882 YOR100C +r_3607 YCR098C +r_1574 YKL120W +r_1642 YPR011C +r_1684 ( YGL077C or YOR161C ) +r_3959 YBR192W +r_3680 YHR002W +r_3960 YBR192W +r_1760 ( YIL013C or YOR011W ) +r_1803 YGL225W +r_2094 ( YLL052C or YPR192W ) +r_3526 ( YLL052C or YPR192W ) +r_3604 ( YLL052C or YLL053C or YPR192W ) +r_1179 ( YJL133W or YKR052C ) +r_1657 YBR147W +r_1658 YDR508C +r_1811 YPR058W +r_1837 YBR147W +r_1919 YBR147W +r_1935 YDR508C +r_1907 YKR039W +r_2045 YDR508C +r_3545 YKR039W +r_2072 YDR508C +r_1771 ( YKL188C and YPL147W ) +r_1772 ( YKL188C and YPL147W ) +r_1976 YOR100C +r_2231 ( YKL188C and YPL147W ) +r_1774 ( YKL188C and YPL147W ) +r_3961 ( YER053C or YJR077C or YLR348C ) +r_2008 YNR013C +r_3605 ( YCR037C or YJL198W or YML123C ) +r_3649 YNR013C +r_3893 YIL048W +r_3813 ( YIL048W or YMR162C ) +r_3897 YIL048W +r_3817 ( YIL048W or YMR162C ) +r_3894 YIL048W +r_3814 ( YIL048W or YMR162C ) +r_3898 YIL048W +r_3818 ( YIL048W or YMR162C ) +r_3895 YIL048W +r_3815 ( YIL048W or YMR162C ) +r_3899 YIL048W +r_3819 ( YIL048W or YMR162C ) +r_3896 YIL048W +r_3816 ( YIL048W or YMR162C ) +r_3900 YIL048W +r_3820 ( YIL048W or YMR162C ) +r_3821 YAL026C +r_3885 YAL026C +r_3825 YAL026C +r_3889 YAL026C +r_3822 YAL026C +r_3886 YAL026C +r_3826 YAL026C +r_3890 YAL026C +r_3823 YAL026C +r_3887 YAL026C +r_3827 YAL026C +r_3891 YAL026C +r_3824 YAL026C +r_3888 YAL026C +r_3828 YAL026C +r_3892 YAL026C +r_3606 YCR098C +r_1236 ( YKL188C and YPL147W ) +r_2107 ( YIL013C or YOR011W ) diff --git a/ComplementaryData/modelCuration/databasenewGPR.tsv b/ComplementaryData/modelCuration/databasenewGPR.tsv index a3d47cfb..50d302e6 100644 --- a/ComplementaryData/modelCuration/databasenewGPR.tsv +++ b/ComplementaryData/modelCuration/databasenewGPR.tsv @@ -1,50 +1,50 @@ -rxnID_yeast_model genes_yeast_model final_GPR -r_0308 YGL184C ( YFR055W or YGL184C ) -r_0148 YDR226W ( YDL166C or YDR226W ) -r_1729 NAN YDL166C -r_1077 YNR012W ( YDR020C or YNR012W ) -r_1078 YNR012W ( YDR020C or YNR012W ) -r_0226 (( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YPR020W )) (( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YPR020W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YJL180C and YLR393W and YNL315C and YOL077W-A and YCL005W-A)) -r_0364 YBR252W ( YJR069C or YBR252W ) -r_0815 YAL012W ( YLL058W or YML082W or YAL012W ) -r_0448 YJL155C ( YLR345W or YJL155C ) -r_0534 ( YCL040W or YFR053C or YGL253W ) ( YLR446W or YCL040W or YFR053C or YGL253W ) -r_0533 ( YFR053C or YGL253W ) ( YLR446W or YFR053C or YGL253W ) -r_0535 ( YFR053C or YGL253W ) ( YLR446W or YFR053C or YGL253W ) -r_0477 YKL104C ( YMR084W or YKL104C ) -r_2116 ( YMR170C or YER073W or YOR374W ) ( YMR110C or YMR170C or YER073W or YOR374W ) -r_0172 ( YMR169C or YMR170C ) ( YMR110C or YMR169C or YMR170C ) -r_0483 ( YBR244W or YCL035C or YDR513W or YIR037W or YKL026C ) ( YNL229C or YBR244W or YCL035C or YDR513W or YIR037W or YKL026C ) -r_2025 NAN YNR027W -r_1185 YBR293W ( YOL092W or YBR293W ) -r_1200 ( YBR293W or YCL069W or YMR088C ) ( YOL092W or YBR293W or YCL069W or YMR088C ) -r_1212 ( YBR293W or YCL069W or YMR088C ) ( YOL092W or YBR293W or YCL069W or YMR088C ) -r_0366 ( YGR254W or YHR174W ) ( YPL281C or YGR254W or YHR174W or YMR323W or YOR393W) -r_1805 NAN ( YBR241C or YGL104C ) -r_0783 YLR328W ( YCL047C or YLR328W ) -r_0530 ( YDR376W and YPL252C ) ( YER141W or (YDR376W and YPL252C) ) -r_1084 YKL035W ( YHL012W or YKL035W ) -r_0475 NAN YFL060C -r_4049 NAN ( YBL035C or YBR278W or YCR014C or YIR008C or YKL045W or YDL102W or YDL164C or YDR121W or YDR419W or YJR006W or YJR043C or YNL102W or YNL262W or YOR330C or YPL167C or YPR175W or YKR002W ) -r_4050 NAN ( YBR154C or YHR143W-A or YIL021W or YKL144C or YKR025W or YFL036W or YDL140C or YDL150W or YDR045C or YDR156W or YDR404C or YGL070C or YJL011C or YJL140W or YJL148W or YJR063W or YNL113W or YNL151C or YNL248C or YNR003C or YOL005C or YOR116C or YOR151C or YOR207C or YOR210W or YOR224C or YOR340C or YOR341W or YPR010C or YPR110C or YPR187W or YPR190C ) -r_0438 (( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YIL111W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YLR038C and YLR395C and YMR256C and YNL052W ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YIL111W and YJR048W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YJR048W and YLR038C and YLR395C and YMR256C and YNL052W )) (( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YIL111W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YLR038C and YLR395C and YMR256C and YNL052W ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YIL111W and YJR048W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YJR048W and YLR038C and YLR395C and YMR256C and YNL052W ) or (Q0045 and Q0250 and Q0275 and YDL067C and YHR116W and YDR231C and YGR062C and YJL003W and YPL132W and YLL018C-A)) -r_1166 ( YDL245C or YDL247W or YDR342C or YDR343C or YDR345C or YDR536W or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YJR160C or YLR081W or YMR011W or YNR072W or YOL156W ) ( YDL245C or YDL247W or YDR342C or YDR343C or YDR345C or YDR536W or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YJR160C or YLR081W or YMR011W or YNR072W or YOL156W or YDR387C ) -r_3264 ( YBR204C or YKR089C or YMR313C or YOR081C ) ( YBR204C or YKR089C or YMR313C or YOR081C or YCR068W ) -r_3297 YMR313C ( YCR068W or YMR313C ) -r_0804 YER005W ( YAL035W or YLL001W or YER005W ) -r_1667 NAN YNL036W -r_0005 ( YGR032W or ( YLR342W and YCR034W )) ( YGR032W or YMR306W or ( YLR342W and YCR034W )) -r_1172 YLL043W ( YFL054C or YLL043W ) -r_1217 YDR105C ( YCL025C or YDR508C or YFL055W or YKR039W or YPL265W or YDR105C ) -r_1258 YLR138W ( YDR456W or YLR138W) -r_1249 YJL129C ( YDR456W or YJL129C ) -r_0193 YPR026W ( YPR026W or YBR001C ) -r_2064 NAN YDL024C -r_0323 YJR159W ( YDL246C or YJR159W ) -r_0199 YMR293C ( YDR242W or YMR293C ) -r_0139 YML022W ( YDR441C or YML022W) -r_0542 YDR234W ( YJL200C or YDR234W ) -r_0893 YKL152C ( YOR283W or YKL152C ) -r_1048 YLR354C ( YGR043C or YLR354C ) -r_1021 (YDR178W and YJL045W and YKL141W and YLL041C) or (YDR178W and YKL141W and YKL148C and YLL041C) (YDR178W and YJL045W and YKL141W and YLL041C) or (YDR178W and YKL141W and YKL148C and YLL041C) or ( YLR164W and YJL045W and YKL141W and YLL041C) -r_0475 YFL060C ( YFL060C or YNL334C ) +rxnID_yeast_model genes_yeast_model final_GPR +r_0308 YGL184C ( YFR055W or YGL184C ) +r_0148 YDR226W ( YDL166C or YDR226W ) +r_1729 NAN YDL166C +r_1077 YNR012W ( YDR020C or YNR012W ) +r_1078 YNR012W ( YDR020C or YNR012W ) +r_0226 (( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YPR020W )) (( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YPR020W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YJL180C and YLR393W and YNL315C and YOL077W-A and YCL005W-A)) +r_0364 YBR252W ( YJR069C or YBR252W ) +r_0815 YAL012W ( YLL058W or YML082W or YAL012W ) +r_0448 YJL155C ( YLR345W or YJL155C ) +r_0534 ( YCL040W or YFR053C or YGL253W ) ( YLR446W or YCL040W or YFR053C or YGL253W ) +r_0533 ( YFR053C or YGL253W ) ( YLR446W or YFR053C or YGL253W ) +r_0535 ( YFR053C or YGL253W ) ( YLR446W or YFR053C or YGL253W ) +r_0477 YKL104C ( YMR084W or YKL104C ) +r_2116 ( YMR170C or YER073W or YOR374W ) ( YMR110C or YMR170C or YER073W or YOR374W ) +r_0172 ( YMR169C or YMR170C ) ( YMR110C or YMR169C or YMR170C ) +r_0483 ( YBR244W or YCL035C or YDR513W or YIR037W or YKL026C ) ( YNL229C or YBR244W or YCL035C or YDR513W or YIR037W or YKL026C ) +r_2025 NAN YNR027W +r_1185 YBR293W ( YOL092W or YBR293W ) +r_1200 ( YBR293W or YCL069W or YMR088C ) ( YOL092W or YBR293W or YCL069W or YMR088C ) +r_1212 ( YBR293W or YCL069W or YMR088C ) ( YOL092W or YBR293W or YCL069W or YMR088C ) +r_0366 ( YGR254W or YHR174W ) ( YPL281C or YGR254W or YHR174W or YMR323W or YOR393W) +r_1805 NAN ( YBR241C or YGL104C ) +r_0783 YLR328W ( YCL047C or YLR328W ) +r_0530 ( YDR376W and YPL252C ) ( YER141W or (YDR376W and YPL252C) ) +r_1084 YKL035W ( YHL012W or YKL035W ) +r_0475 NAN YFL060C +r_4049 NAN ( YBL035C or YBR278W or YCR014C or YIR008C or YKL045W or YDL102W or YDL164C or YDR121W or YDR419W or YJR006W or YJR043C or YNL102W or YNL262W or YOR330C or YPL167C or YPR175W or YKR002W ) +r_4050 NAN ( YBR154C or YHR143W-A or YIL021W or YKL144C or YKR025W or YFL036W or YDL140C or YDL150W or YDR045C or YDR156W or YDR404C or YGL070C or YJL011C or YJL140W or YJL148W or YJR063W or YNL113W or YNL151C or YNL248C or YNR003C or YOL005C or YOR116C or YOR151C or YOR207C or YOR210W or YOR224C or YOR340C or YOR341W or YPR010C or YPR110C or YPR187W or YPR190C ) +r_0438 (( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YIL111W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YLR038C and YLR395C and YMR256C and YNL052W ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YIL111W and YJR048W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YJR048W and YLR038C and YLR395C and YMR256C and YNL052W )) (( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YIL111W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YLR038C and YLR395C and YMR256C and YNL052W ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YIL111W and YJR048W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YJR048W and YLR038C and YLR395C and YMR256C and YNL052W ) or (Q0045 and Q0250 and Q0275 and YDL067C and YHR116W and YDR231C and YGR062C and YJL003W and YPL132W and YLL018C-A)) +r_1166 ( YDL245C or YDL247W or YDR342C or YDR343C or YDR345C or YDR536W or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YJR160C or YLR081W or YMR011W or YNR072W or YOL156W ) ( YDL245C or YDL247W or YDR342C or YDR343C or YDR345C or YDR536W or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YJR160C or YLR081W or YMR011W or YNR072W or YOL156W or YDR387C ) +r_3264 ( YBR204C or YKR089C or YMR313C or YOR081C ) ( YBR204C or YKR089C or YMR313C or YOR081C or YCR068W ) +r_3297 YMR313C ( YCR068W or YMR313C ) +r_0804 YER005W ( YAL035W or YLL001W or YER005W ) +r_1667 NAN YNL036W +r_0005 ( YGR032W or ( YLR342W and YCR034W )) ( YGR032W or YMR306W or ( YLR342W and YCR034W )) +r_1172 YLL043W ( YFL054C or YLL043W ) +r_1217 YDR105C ( YCL025C or YDR508C or YFL055W or YKR039W or YPL265W or YDR105C ) +r_1258 YLR138W ( YDR456W or YLR138W) +r_1249 YJL129C ( YDR456W or YJL129C ) +r_0193 YPR026W ( YPR026W or YBR001C ) +r_2064 NAN YDL024C +r_0323 YJR159W ( YDL246C or YJR159W ) +r_0199 YMR293C ( YDR242W or YMR293C ) +r_0139 YML022W ( YDR441C or YML022W) +r_0542 YDR234W ( YJL200C or YDR234W ) +r_0893 YKL152C ( YOR283W or YKL152C ) +r_1048 YLR354C ( YGR043C or YLR354C ) +r_1021 (YDR178W and YJL045W and YKL141W and YLL041C) or (YDR178W and YKL141W and YKL148C and YLL041C) (YDR178W and YJL045W and YKL141W and YLL041C) or (YDR178W and YKL141W and YKL148C and YLL041C) or ( YLR164W and YJL045W and YKL141W and YLL041C) +r_0475 YFL060C ( YFL060C or YNL334C ) diff --git a/ComplementaryData/modelCuration/metabolite_manual_curation.tsv b/ComplementaryData/modelCuration/metabolite_manual_curation.tsv index 502995d8..41ad9af9 100644 --- a/ComplementaryData/modelCuration/metabolite_manual_curation.tsv +++ b/ComplementaryData/modelCuration/metabolite_manual_curation.tsv @@ -1,475 +1,475 @@ -name_original name_correct CHEBI KEGG charge remark -(R)-3-hydroxybutanoyl-CoA (R)-3-hydroxybutanoyl-CoA CHEBI:15452 C03561 0 wrong chebiID and keggid. update keggid, formula. has formula in charge of -4. -(R)-3-hydroxy-cis-dodec-5-enoyl-CoA (R)-3-hydroxy-cis-dodec-5-enoyl-CoA 0 wrong chebiID and keggid. Can't find from database -(R)-3-hydroxy-cis-hexadec-7-enoyl-CoA (R)-3-hydroxy-cis-hexadec-7-enoyl-CoA CHEBI:88087 0 wrong chebiID and keggid. CHEBI:88087 for (3S.7Z)-3-hydroxyhexadecenoyl-CoA -(R)-3-hydroxy-cis-hexadec-9-enoyl-CoA (R)-3-hydroxy-cis-hexadec-9-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:87781 for (3S)-3-hydroxyoleoyl-CoA. (3S.9Z)-3-hydroxyoctadec-9-enoyl-CoA;remove duplicated chebiID" -(R)-3-hydroxy-cis-octadec-9-enoyl-CoA (R)-3-hydroxy-cis-octadec-9-enoyl-CoA CHEBI:87781 0 wrong chebiID and keggid. CHEBI:87781 for (3S)-3-hydroxyoleoyl-CoA. (3S.9Z)-3-hydroxyoctadec-9-enoyl-CoA -(R)-3-hydroxy-cis-tetradec-5-enoyl-CoA (R)-3-hydroxy-cis-tetradec-5-enoyl-CoA CHEBI:88072 0 wrong chebiID and keggid. CHEBI:88072 for (3S.5Z)-3-hydroxytetradec-5-enoyl-CoA -(R)-3-hydroxy-cis-tetradec-7-enoyl-CoA (R)-3-hydroxy-cis-tetradec-7-enoyl-CoA 0 wrong chebiID and keggid. No chebiID. (3S)-Hydroxy-cis-tetradec-7-enoyl-CoA. C35H56N7O18P3S. https://webapps.molecular-networks.com/biopath3/biopath/mols/(3S)-Hydroxy-cis-tetradec-7-enoyl-CoA -(R)-3-hydroxydocosanoyl-CoA (R)-3-hydroxydocosanoyl-CoA CHEBI:76375 -4 wrong chebiID and keggid. Update charge -(R)-3-hydroxyhexanoyl-CoA (R)-3-hydroxyhexanoyl-CoA CHEBI:74474 0 wrong chebiID and keggid -(R)-3-hydroxyicosanoyl-CoA (R)-3-hydroxyicosanoyl-CoA CHEBI:76453 0 wrong chebiID and keggid -(R)-3-hydroxyoctanoyl-CoA (R)-3-hydroxyoctanoyl-CoA CHEBI:28573 C05278 0 wrong chebiID and wrong keggid -(R)-3-hydroxytetracosanoyl-CoA (R)-3-hydroxytetracosanoyl-CoA CHEBI:76463 0 wrong chebiID and keggid -(S)-3-hydroxyhexacosanoyl-CoA (S)-3-hydroxyhexacosanoyl-CoA CHEBI:52976 0 Wrong CHEBI in erm. Wrong KEGG in erm. -(S)-3-hydroxypalmitoyl-CoA (S)-3-hydroxypalmitoyl-CoA CHEBI:27402 C05258 0 Wrong CHEBI in erm. Wrong KEGG in erm. -(S)-3-hydroxytetradecanoyl-CoA (S)-3-hydroxytetradecanoyl-CoA CHEBI:27466 C05260 0 Wrong CHEBI in erm. Wrong KEGG in erm. -1-(sn-glycero-3-phospho)-1D-myo-inositol 1-(sn-glycero-3-phospho)-1D-myo-inositol CHEBI:58444 C01225 -1 Wrong CHEBI in ce. Wrong KEGG in ce. -1,2-diacylglycerol 3-diphosphate (1-16:0, 2-16:1) 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-16:1) 0 Wrong charge in vm/gm. -1,2-diacylglycerol 3-diphosphate (1-16:0, 2-18:1) 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-18:1) CHEBI:34087 C13890 0 new chebiID. new keggid. CHEBI:34087 for 1-O-hexadecanoyl-2-O-[(Z)-octadec-9-enoyl]-sn-glycerol 3-diphosphate has charge of 0 the chain of chebi 34087 is same to this metabolite.Manually calculated based on 1.2-diacylglycerol 3-diphosphate -1,2-diacylglycerol 3-diphosphate (1-16:1, 2-16:1) 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-16:1) 0 Wrong charge in vm/gm. -1,2-diacylglycerol 3-diphosphate (1-16:1, 2-18:1) 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-18:1) 0 Wrong charge in vm/gm. -1,2-diacylglycerol 3-diphosphate (1-18:0, 2-16:1) 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-16:1) 0 Wrong charge in vm/gm. -1,2-diacylglycerol 3-diphosphate (1-18:0, 2-18:1) 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-18:1) 0 Wrong charge in vm/gm. -1,2-diacylglycerol 3-diphosphate (1-18:1, 2-16:1) 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-16:1) 0 Wrong charge in vm/gm. -1,2-diacylglycerol 3-diphosphate (1-18:1, 2-18:1) 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-18:1) 0 Wrong charge in vm/gm. -14-demethyllanosterol 14-demethyllanosterol CHEBI:18364 C05108 0 Wrong CHEBI in e. Wrong KEGG in e. -1-acylglycerophosphocholine (16:0) 1-acylglycerophosphocholine (16:0) 1 Update charge. Manually calculated based on 1-acylglycerophosphocholine(1+) -1-acylglycerophosphocholine (16:1) 1-acylglycerophosphocholine (16:1) 1 Update charge. Manually calculated based on 1-acylglycerophosphocholine(1+) -1-acylglycerophosphocholine (18:0) 1-acylglycerophosphocholine (18:0) 1 Update charge. Manually calculated based on 1-acylglycerophosphocholine(1+) -1-acylglycerophosphocholine (18:1) 1-acylglycerophosphocholine (18:1) 1 Update charge. Manually calculated based on 1-acylglycerophosphocholine(1+) -1-acylglycerophosphoethanolamine (16:0) 1-acylglycerophosphoethanolamine (16:0) CHEBI:90452 0 new chebiID. CHEBI:90452 for lysophosphatidylethanolamine 16:0. has charge of 0. based on chebi:136148Manually calculated based on 1-O-acylglycerophosphoethanolamine -1-acylglycerophosphoethanolamine (16:1) 1-acylglycerophosphoethanolamine (16:1) 0 Wrong charge in erm/ce/lp. -1-acylglycerophosphoethanolamine (18:0) 1-acylglycerophosphoethanolamine (18:0) CHEBI:64576 0 new chebiID. CHEBI:64576 for lysophosphatidylethanolamine 18:0. has charge of 0. Manually calculated based on 1-O-acylglycerophosphoethanolamine -1-acylglycerophosphoethanolamine (18:1) 1-acylglycerophosphoethanolamine (18:1) CHEBI:64575 0 new chebiID. CHEBI:64575 for lysophosphatidylethanolamine 18:1. has charge of 0. Manually calculated based on 1-O-acylglycerophosphoethanolamine -1-acylglycerophosphoinositol (16:0) 1-acylglycerophosphoinositol (16:0) CHEBI:73218 0 new chebiID. CHEBI:73218 for 1-hexadecanoyl-sn-glycero-3-phospho-D-myo-inositol PI(16:0/0:0) has new chebiID. charge of 0. Manually calculated based on 1-acylglycerophosphoinositol -1-acylglycerophosphoinositol (16:1) 1-acylglycerophosphoinositol (16:1) CHEBI:138108 0 new chebiID. CHEBI:138108 for 2-palmitoleoyl-sn-glycero-3-phospho-D-myo-inositol. has charge of 0.Manually calculated based on 1-acylglycerophosphoinositol -1-acylglycerophosphoinositol (18:0) 1-acylglycerophosphoinositol (18:0) CHEBI:83054 0 new chebiID. CHEBI:83054 for 1-stearoyl-sn-glycero-3-phospho-1D-myo-inositol PI(18:0/0:0). has charge of 0. Manually calculated based on 1-acylglycerophosphoinositol -1-acylglycerophosphoinositol (18:1) 1-acylglycerophosphoinositol (18:1) CHEBI:82753 0 new chebiID. CHEBI:82753 for 1-oleoyl-sn-glycero-3-phospho-D-myo-inositol PI(18:1/0:0). has charge of 0. Manually calculated based on 1-acylglycerophosphoinositol -1-acylglycerophosphoserine (16:0) 1-acylglycerophosphoserine (16:0) 0 Wrong charge in ce. -1-acylglycerophosphoserine (16:1) 1-acylglycerophosphoserine (16:1) 0 Wrong charge in ce. -1-acylglycerophosphoserine (18:0) 1-acylglycerophosphoserine (18:0) 0 Wrong charge in ce. -1-acylglycerophosphoserine (18:1) 1-acylglycerophosphoserine (18:1) 0 Wrong charge in ce. -1-acyl-sn-glycerol 3-phosphate (16:0) 1-acyl-sn-glycerol 3-phosphate (16:0) CHEBI:15799 C04036 0 new chebiID. new keggid -1-acyl-sn-glycerol 3-phosphate (16:1) 1-acyl-sn-glycerol 3-phosphate (16:1) CHEBI:75070 0 new chebiID -1-acyl-sn-glycerol 3-phosphate (18:0) 1-acyl-sn-glycerol 3-phosphate (18:0) CHEBI:74850 0 new chebiID -1-acyl-sn-glycerol 3-phosphate (18:1) 1-acyl-sn-glycerol 3-phosphate (18:1) CHEBI:62837 0 new chebiID -1D-myo-inositol 1,4,5-trisphosphate 1D-myo-inositol 1,4,5-trisphosphate CHEBI:203600 C01245 -6 Wrong CHEBI in c. Wrong KEGG in c. -1-monoglyceride (16:0) 1-monoglyceride (16:0) CHEBI:134127 0 new chebiID -1-monoglyceride (16:1) 1-monoglyceride (16:1) CHEBI:134128 0 new chebiID -1-monoglyceride (18:0) 1-monoglyceride (18:0) CHEBI:134129 0 new chebiID -1-monoglyceride (18:1) 1-monoglyceride (18:1) CHEBI:134130 0 new chebiID -1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) CHEBI:88396 0 new chebiID. CHEBI:16749 for 1-phosphatidyl-1D-myo-inositol. has charge of -1 -1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) CHEBI:73215 C13888 0 new chebiID. new keggid -1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1) 0 Wrong charge in erm/ce/vm/gm/n/c. -1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1) CHEBI:88562 0 new chebiID -1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) CHEBI:88557 0 new chebiID -1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) CHEBI:77346 0 new chebiID -1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1) CHEBI:88626 0 new chebiID -1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1) CHEBI:88612 0 new chebiID -1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1) 0 Wrong charge in vm/ce/c. -1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1) 0 Wrong charge in vm/ce/c. -1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1) 0 Wrong charge in vm/ce/c. -1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1) 0 Wrong charge in vm/ce/c. -1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1) 0 Wrong charge in vm/ce/c. -1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1) 0 Wrong charge in vm/ce/c. -1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1) 0 Wrong charge in vm/ce/c. -1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1) 0 Wrong charge in vm/ce/c. -1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1) 0 Wrong charge in vm/ce/c/erm/gm. -1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1) 0 Wrong charge in vm/ce/c/erm/gm. -1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1) 0 Wrong charge in vm/ce/c/erm/gm. -1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1) 0 Wrong charge in vm/ce/c/erm/gm. -1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1) 0 Wrong charge in vm/ce/c/erm/gm. -1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1) CHEBI:77347 0 new chebiID. CHEBI:77347 for 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate Phosphatidylinositol Phosphate(18:0/18:1). has charge of 0. in structure 3-phosphate is like 5 -phosphate in Benzene ring. Manually calculated based on 1-phosphatidyl-1D-myo-inositol 3-phosphate -1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1) 0 Wrong charge in vm/ce/c/erm/gm. -1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1) CHEBI:77344 0 new chebiID. CHEBI:7734 for1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate Phosphatidylinositol Phosphate(18:0/18:2). has charge of 0. Manually calculated based on 1-phosphatidyl-1D-myo-inositol 3-phosphate -1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1) 0 Wrong charge in n/ce/c/erm. -1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1) 0 Wrong charge in n/ce/c/erm. -1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1) 0 Wrong charge in n/ce/c/erm. -1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1) 0 Wrong charge in n/ce/c/erm. -1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1) 0 Wrong charge in n/ce/c/erm. -1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1) CHEBI:77279 0 new chebiID. CHEBI:77279 for 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-1D-myo-inositol 4.5-biphosphate. has charge of 0. Manually calculated based on 1-phosphatidyl-1D-myo-inositol 4.5-phosphate -1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1) 0 Wrong charge in n/ce/c/erm. -1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1) 0 Wrong charge in n/ce/c/erm. -1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1) 0 Wrong charge in ce/vm/gm/n/c/erm. -1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1) 0 Wrong charge in ce/vm/gm/n/c/erm. -1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1) 0 Wrong charge in ce/vm/gm/n/c/erm. -1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1) 0 Wrong charge in ce/vm/gm/n/c/erm. -1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1) 0 Wrong charge in ce/vm/gm/n/c/erm. -1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1) CHEBI:77277 0 new chebiID. CHEBI:77277 for 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate. has charge of 0. Manually calculated based on 1-phosphatidyl-1D-myo-inositol 4-phosphate -1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1) 0 Wrong charge in ce/vm/gm/n/c/erm. -1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1) 0 Wrong charge in ce/vm/gm/n/c/erm. -2-isopropylmalate 2-isopropylmalate CHEBI:28107 C02504 -2 Wrong chebiID. -3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-16:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-16:1) 0 Wrong charge in mm. -3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1) 0 Wrong charge in mm. -3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-16:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-16:1) 0 Wrong charge in mm. -3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-18:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-18:1) 0 Wrong charge in mm. -3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:0, 2-16:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:0, 2-16:1) 0 Wrong charge in mm. -3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:1, 2-16:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:1, 2-16:1) 0 Wrong charge in mm. -3-hydroxybutanoyl-ACP 3-hydroxybutanoyl-ACP C04618 0 Wrong chebiID and keggid. Can't find such a metabolite in chebi -3-hydroxydocosanoyl-CoA 3-hydroxydocosanoyl-CoA CHEBI:52325 0 wrong chebiID and keggid -3-hydroxyhexanoyl-ACP 3-hydroxyhexanoyl-ACP CHEBI:326 C05747 0 wrong chebiID and fullname and keggid -3-hydroxyicosanoyl-CoA 3-hydroxyicosanoyl-CoA CHEBI:52324 0 wrong chebiID and charge and keggid -3-hydroxyoctadecanoyl-CoA 3-hydroxyoctadecanoyl-CoA CHEBI:50583 C16217 0 Wrong CHEBI in erm. Wrong KEGG in erm. -3-hydroxyoctanoyl-ACP 3-hydroxyoctanoyl-ACP CHEBI:80387 C16220 0 wrong chebiID and keggid. Not standard fullname -3-hydroxytetracosanoyl-CoA 3-hydroxytetracosanoyl-CoA CHEBI:52326 0 wrong chebiID and keggid -3-oxo-cis-dodec-5-enoyl-CoA 3-oxo-cis-dodec-5-enoyl-CoA 0 wrong chebiID and keggid. PubChem CID: 90658857 for (5E)-3-oxo-dodecenoyl-CoA. https://pubchem.ncbi.nlm.nih.gov/compound/90658857#section=Top C33H50N7O18P3S(-4) -3-oxo-cis-hexadec-7-enoyl-CoA 3-oxo-cis-hexadec-7-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:88008 for (7Z)-hexadecenoyl-CoA;remove duplicated chebiID" -3-oxo-cis-hexadec-9-enoyl-CoA 3-oxo-cis-hexadec-9-enoyl-CoA CHEBI:53152 0 wrong chebiID and keggid. CHEBI:53152 for palmitoleoyl-CoA cis-9-hexadecenoyl-CoA -3-oxo-cis-octadec-9-enoyl-CoA 3-oxo-cis-octadec-9-enoyl-CoA CHEBI:78146 0 wrong chebiID and keggID. CHEBI:78146 for trans-9-octadecenoyl-CoA. Has charge of -4 -3-oxo-cis-tetradec-5-enoyl-CoA 3-oxo-cis-tetradec-5-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:70712 for (5Z)-tetradecenoyl-CoA. cis-5-tetradecenoyl-CoA;remove duplicated chebiID" -3-oxo-cis-tetradec-7-enoyl-CoA 3-oxo-cis-tetradec-7-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:62014 for cis-tetradec-3-enoyl-CoA. No cis-tetradec-7-enoyl-CoA;remove duplicated chebiID" -3-oxodocosanoyl-CoA 3-oxodocosanoyl-CoA CHEBI:52328 0 wrong chebiID and keggid -3-oxohexacosanoyl-CoA 3-oxohexacosanoyl-CoA CHEBI:52977 0 Wrong CHEBI in erm. Wrong KEGG in erm. -3-oxo-hexanoyl-ACP 3-oxo-hexanoyl-ACP CHEBI:1642 C05746 0 wrong chebiID and keggid -3-oxohexanoyl-CoA 3-oxohexanoyl-CoA CHEBI:27648 C05269 0 wrong chebiID and keggid. update keggid, formula. has formula in charge of -4. -3-oxoicosanoyl-CoA 3-oxoicosanoyl-CoA CHEBI:52327 0 wrong chebiID and keggid -3-oxooctadecanoyl-CoA 3-oxooctadecanoyl-CoA CHEBI:50571 C16216 0 Wrong CHEBI in erm. Wrong KEGG in erm. -3-oxo-octanoyl-ACP 3-oxo-octanoyl-ACP CHEBI:1646 C05750 0 wrong chebiID and keggid -3-oxooctanoyl-CoA 3-oxooctanoyl-CoA CHEBI:28264 C05267 0 wrong chebiID and keggid. update keggid, formula. has formula in charge of -4. -3-oxopalmitoyl-CoA 3-oxopalmitoyl-CoA CHEBI:57349 C05259 -4 Wrong CHEBI in erm. Wrong KEGG in erm. -3-oxotetracosanoyl-CoA 3-oxotetracosanoyl-CoA CHEBI:52329 0 wrong chebiID and keggid -3-oxotetradecanoyl-CoA 3-oxotetradecanoyl-CoA CHEBI:28726 C05261 0 Wrong CHEBI in erm. Wrong KEGG in erm. -3-phosphoglycerate 3-phosphonato-D-glycerate(3-) CHEBI:58272 C00197 -3 update fullname. the old keggid is for the molecular form -4beta-methylzymosterol-4alpha-carboxylic acid 4beta-methylzymosterol-4alpha-carboxylic acid CHEBI:50591 C15808 0 New keggid -6-(alpha-D-glucosaminyl)-O-acyl-1-phosphatidyl-1D-myo-inositol 6-(alpha-D-glucosaminyl)-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53055 0 Wrong charge in er. -6-[6-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-2-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-alpha-2-(2-aminoethylphosphoryl)mannosyl-(1->4)-alpha-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol 6-[6-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-2-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-alpha-2-(2-aminoethylphosphoryl)mannosyl-(1->4)-alpha-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53060 0 Wrong charge in er. -6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol 6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53056 0 Wrong charge in er. -6-O-{2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol 6-O-{2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53057 0 Wrong charge in er. -6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53059 0 Wrong charge in er. -6-O-{alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol 6-O-{alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53058 0 Wrong charge in er. -acetoacetyl-ACP acetoacetyl-ACP CHEBI:2393 C05744 0 wrong cheibID and keggid -acetoacetyl-CoA acetoacetyl-CoA CHEBI:57286 C00332 -4 Wrong CHEBI in p. Wrong KEGG in p. -ACP1 ACP1 CHEBI:18359 C00229 0 Wrong chebiID. Wrong full name. should be: holo-[acyl-carrier protein] -acylglycerone phosphate (16:0) acylglycerone phosphate (16:0) CHEBI:17868 C01192 0 new chebiID. new keggid -acylglycerone phosphate (16:1) acylglycerone phosphate (16:1) CHEBI:74694 -2 new chebiID. Update charge. CHEBI:74694 for 1-palmitoleoyl-sn-glycerol 3-phosphate(2-) -acylglycerone phosphate (18:0) acylglycerone phosphate (18:0) CHEBI:36476 C03805 -2 new chebiID. new keggid. Update charge. chebi has some problem.this is a charged chebi id 2- -acylglycerone phosphate (18:1) acylglycerone phosphate (18:1) CHEBI:36475 C03630 0 new chebiID. new keggid -ADP ADP CHEBI:456216 C00008 -3 Wrong CHEBI in ce/vm/gm. Wrong KEGG in ce/vm/gm. -Ala-tRNA(Ala) Ala-tRNA(Ala) CHEBI:17732 C00886 0 Wrong charge in c. -alpha-D-ribose 1-phosphate alpha-D-ribose 1-phosphate(2-) CHEBI:57720 C00620 -2 update fullname and kegg id. the new keggid is for the molecular form -AMP AMP CHEBI:456215 C00020 -2 Wrong CHEBI in erm/lp/ce. Wrong KEGG in erm/lp/ce. -arachidate arachidate CHEBI:32360 -1 Wrong chebiID and keggid. Update formula and charge -Arg-tRNA(Arg) Arg-tRNA(Arg) CHEBI:18366 C02163 0 Wrong charge in c/m. -Asn-tRNA(Asn) Asn-tRNA(Asn) CHEBI:29265 C03402 0 Wrong charge in c/m. -Asp-tRNA(Asp) Asp-tRNA(Asp) CHEBI:29158 C02984 0 Wrong charge in c/m. -ATP ATP CHEBI:30616 C00002 -4 Wrong CHEBI in erm/lp/ce/vm/gm. Wrong KEGG in erm/lp/ce/vm/gm. -behenate behenate CHEBI:23858 C08281 -1 wrong chebiID and keggid. Update charge -biomass biomass 0 Wrong charge in c. -butanoyl-ACP butanoyl-ACP CHEBI:3247 C05745 0 wrong chebiID and keggid. Not standard fullname -butanoyl-CoA butanoyl-CoA CHEBI:15517 C00136 0 wrong chebiID and keggid. Has charge of -4 -butyrate butyrate CHEBI:17968 C00246 -1 wrong chebiID and keggid. update keggid, formula and charge -carbon dioxide carbon dioxide CHEBI:16526 C00011 0 Wrong CHEBI in erm/mm/gm/vm. Wrong KEGG in erm/mm/gm/vm. -cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1) cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1) cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1) cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1) cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1) cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1) cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-18:1) cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-16:1) cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-18:1) cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1) cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1) cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-18:1, 3-18:0, 4-16:1) cardiolipin (1-16:0, 2-18:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1) cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-18:1) cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1) cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1) cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1) cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1) CHEBI:104873 0 new chebiID. CHEBI:104873 for tetrahexadec-9-enoyl cardiolipin CL(16:1/16:1/16:1/16:1). has charge of 0. Manually calculated based on cardiolipin -cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1) cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1) cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1) cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-18:1) cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1) cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1) cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1) cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1) cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1) cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1) cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-18:1) cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-16:1) cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-18:1) cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1) cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1) cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-18:0, 2-16:1, 3-18:0, 4-16:1) cardiolipin (1-18:0, 2-16:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1) cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-18:1) cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1) cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1) cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1) cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1) cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1) cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1) cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-18:1) cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1) cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1) cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-16:1) cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-18:1) cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1) cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. -cardiolipin (1-18:1, 2-18:1, 3-18:1, 4-16:1) cardiolipin (1-18:1, 2-18:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. -CDP CDP CHEBI:58069 C00112 -3 Wrong CHEBI in erm. Wrong KEGG in erm. -CDP-choline CDP-choline CHEBI:16436 C00307 0 Wrong CHEBI in erm. Wrong KEGG in erm. -CDP-diacylglycerol (1-16:0, 2-16:1) CDP-diacylglycerol (1-16:0, 2-16:1) 0 Wrong charge in erm/mm. -CDP-diacylglycerol (1-16:0, 2-18:1) CDP-diacylglycerol (1-16:0, 2-18:1) CHEBI:34077 C13892 0 new keggid -CDP-diacylglycerol (1-16:1, 2-16:1) CDP-diacylglycerol (1-16:1, 2-16:1) CHEBI:104012 0 new chebiID -CDP-diacylglycerol (1-16:1, 2-18:1) CDP-diacylglycerol (1-16:1, 2-18:1) 0 Wrong charge in erm/mm. -CDP-diacylglycerol (1-18:0, 2-16:1) CDP-diacylglycerol (1-18:0, 2-16:1) 0 No chebi id found. ECMDB23374 -CDP-diacylglycerol (1-18:0, 2-18:1) CDP-diacylglycerol (1-18:0, 2-18:1) 0 Wrong charge in erm. -CDP-diacylglycerol (1-18:1, 2-16:1) CDP-diacylglycerol (1-18:1, 2-16:1) 0 Wrong charge in erm/mm. -CDP-diacylglycerol (1-18:1, 2-18:1) CDP-diacylglycerol (1-18:1, 2-18:1) CHEBI:104362 0 new chebiID. CHEBI:104362 for 1.2-dioctadec-11-enoyl-sn-glycero-3-cytidine 5'-diphosphate CDP-DG(18:1/18:1) -CDP-ethanolamine CDP-ethanolamine CHEBI:57876 C00570 -1 Wrong CHEBI in erm. Wrong KEGG in erm. -cerotic acid cerotic acid CHEBI:31013 -1 Wrong CHEBI in ce/erm/lp. Wrong KEGG in ce/erm/lp. -cis-dec-3-enoyl-CoA cis-dec-3-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:10723 for trans-dec-2-enoyl-CoA;remove duplicated chebiID;remove duplicated keggID" -cis-dodec-3-enoyl-CoA cis-dodec-3-enoyl-CoA CHEBI:27989 0 "wrong chebiID and keggid;remove duplicated keggID" -cis-dodec-5-enoyl-CoA cis-dodec-5-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:27989 for cis-dodec-3-enoyl-CoA;remove duplicated chebiID;remove duplicated keggID" -cis-hexadec-7-enoyl-CoA cis-hexadec-7-enoyl-CoA CHEBI:88008 0 wrong chebiID and keggid -cis-tetradec-5-enoyl-CoA cis-tetradec-5-enoyl-CoA CHEBI:70712 0 wrong chebiID and keggid -cis-tetradec-7-enoyl-CoA cis-tetradec-7-enoyl-CoA 0 "Wrong chebiID and keggid .CHEBI:62014 for cis-tetradec-3-enoyl-CoA;remove duplicated chebiID" -CMP CMP CHEBI:60377 C00055 -2 Wrong CHEBI in erm/mm. Wrong KEGG in erm/mm. -coenzyme A coenzyme A CHEBI:57287 C00010 -4 Wrong CHEBI in erm/ce/mm. Wrong KEGG in erm/ce/mm. -CTP CTP CHEBI:37563 C00063 -4 Wrong CHEBI in erm/mm. Wrong KEGG in erm/mm. -Cys-tRNA(Cys) Cys-tRNA(Cys) CHEBI:29152 C03125 0 Wrong charge in c. -diglyceride (1-16:0, 2-16:1) diglyceride (1-16:0, 2-16:1) CHEBI:82929 0 new chebiID -diglyceride (1-16:0, 2-18:1) diglyceride (1-16:0, 2-18:1) CHEBI:88454 0 new chebiID. chebi has some problem. this is 11z -diglyceride (1-16:1, 2-16:1) diglyceride (1-16:1, 2-16:1) CHEBI:84417 0 new chebiID -diglyceride (1-16:1, 2-18:1) diglyceride (1-16:1, 2-18:1) CHEBI:88500 0 new chebiID -diglyceride (1-18:0, 2-16:1) diglyceride (1-18:0, 2-16:1) CHEBI:88527 0 new chebiID -diglyceride (1-18:0, 2-18:1) diglyceride (1-18:0, 2-18:1) CHEBI:75468 0 new chebiID -diglyceride (1-18:1, 2-16:1) diglyceride (1-18:1, 2-16:1) CHEBI:89229 0 new chebiID -diglyceride (1-18:1, 2-18:1) diglyceride (1-18:1, 2-18:1) CHEBI:52333 0 new chebiID -dihydrolipoylprotein dihydrolipoylprotein CHEBI:16194 C02972 0 Wrong charge in m. -dihydroxyacetone phosphate dihydroxyacetone phosphate CHEBI:57642 C00111 -2 Wrong CHEBI in erm. Wrong KEGG in erm. -diphosphate diphosphate CHEBI:33019 C00013 -3 Wrong CHEBI in erm/ce/mm. Wrong KEGG in erm/ce/mm. -D-mannose 6-phosphate D-mannose 6-phosphate CHEBI:17369 C00275 0 Wrong charge in c. -docosanoyl-CoA docosanoyl-CoA CHEBI:65088 C16528 0 Wrong chebiID and keggid. Has charge of -4 -episterol episterol CHEBI:23929 C15777 0 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. -episteryl oleate episteryl oleate CHEBI:52375 0 new chebiID -episteryl palmitoleate episteryl palmitoleate CHEBI:52376 0 new chebiID -ergosta-5,7,22,24(28)-tetraen-3beta-ol ergosta-5,7,22,24(28)-tetraen-3beta-ol CHEBI:18249 C05440 0 Wrong CHEBI in e. Wrong KEGG in e. -ergosta-5,7,24(28)-trien-3beta-ol ergosta-5,7,24(28)-trien-3beta-ol CHEBI:52972 C15780 0 new keggid -ergosterol ergosterol CHEBI:16933 C01694 0 Wrong CHEBI in erm. Wrong KEGG in erm. -ergosteryl oleate ergosteryl oleate CHEBI:52377 0 new chebiID -ergosteryl palmitoleate ergosteryl palmitoleate CHEBI:52378 0 new chebiID -fecosterol fecosterol CHEBI:17038 C04525 0 Wrong CHEBI in erm. Wrong KEGG in erm. -fecosteryl oleate fecosteryl oleate CHEBI:52379 0 new chebiID -fecosteryl palmitoleate fecosteryl palmitoleate CHEBI:52380 0 new chebiID -ferricytochrome c ferricytochrome c CHEBI:15991 C00125 0 Wrong charge in m. -ferrocytochrome c ferrocytochrome c CHEBI:16928 C00126 0 Wrong charge in m. -fMet-tRNA(fMet) fMet-tRNA(fMet) CHEBI:17119 C03294 0 Wrong charge in m. -Gln-tRNA(Gln) Gln-tRNA(Gln) CHEBI:29166 C02282 0 Wrong charge in c. -Glu-tRNA(Glu) Glu-tRNA(Glu) CHEBI:29157 C02987 0 Wrong charge in c/m. -glycerol glycerol CHEBI:17754 C00116 0 Wrong CHEBI in lp. Wrong KEGG in lp. -glycerol 3-phosphate glycerol 3-phosphate CHEBI:57597 C00093 -2 Wrong CHEBI in erm/mm. Wrong KEGG in erm/mm. -glycogen glycogen CHEBI:28087 C00182 0 Wrong charge in c/v. -Gly-tRNA(Gly) Gly-tRNA(Gly) CHEBI:29156 C02412 0 Wrong charge in c. -H+ H+ CHEBI:24636 C00080 1 Wrong CHEBI in erm/mm/gm/vm. Wrong KEGG in erm/mm/gm/vm. -H2O H2O CHEBI:15377 C00001 0 Wrong CHEBI in erm/vm/gm/mm/ce/lp. Wrong KEGG in erm/vm/gm/mm/ce/lp. -heme a heme a CHEBI:24479 C15670 0 Wrong CHEBI in c. Wrong KEGG in c. Wrong charge in m/c. -heme o heme o CHEBI:24480 C15672 0 Wrong charge in m. -hexacosanoyl-CoA hexacosanoyl-CoA CHEBI:52966 0 Wrong CHEBI in erm/ce/lp. Wrong KEGG in erm/ce/lp. -hexanoate hexanoate CHEBI:17120 C01585 -1 Wrong chebiID and keggid. update keggid, formula and charge -hexanoyl-ACP hexanoyl-ACP CHEBI:5704 C05749 0 wrong chebiID and keggid -hexanoyl-CoA hexanoyl-CoA CHEBI:27540 C05270 0 wrong chebiID and keggid. -His-tRNA(His) His-tRNA(His) CHEBI:29155 C02988 0 Wrong charge in c/m. -icosanoyl-CoA icosanoyl-CoA CHEBI:15527 C02041 0 Wrong chebiID and keggid -Ile-tRNA(Ile) Ile-tRNA(Ile) CHEBI:29160 C03127 0 Wrong charge in c/m. -iron iron(2+) CHEBI:29033 C14818 2 update fullname -lanosterol lanosterol CHEBI:16521 C01724 0 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. -lanosteryl oleate lanosteryl oleate CHEBI:52382 0 new chebiID -lanosteryl palmitoleate lanosteryl palmitoleate CHEBI:52383 0 new chebiID -laurate laurate CHEBI:18262 C02679 -1 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. -lauroyl-CoA lauroyl-CoA CHEBI:57375 C01832 -4 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. -Leu-tRNA(Leu) Leu-tRNA(Leu) CHEBI:16624 C02047 0 Wrong charge in c/m. -lignoceric acid lignoceric acid CHEBI:31014 C08320 -1 Wrong CHEBI in ce/erm/lp. Wrong KEGG in ce/erm/lp. -lipid lipid CHEBI:18059 C01356 0 Wrong charge in c. -lipoylprotein lipoylprotein CHEBI:15804 C02051 0 Wrong charge in m. -L-serine L-serine CHEBI:17115 C00065 0 Wrong CHEBI in erm. Wrong KEGG in erm. -Lys-tRNA(Lys) Lys-tRNA(Lys) CHEBI:16047 C01931 0 Wrong charge in c/m. -malonyl-CoA malonyl-CoA CHEBI:57384 C00083 -5 Wrong CHEBI in erm. Wrong KEGG in erm. -mannan mannan CHEBI:28808 C00464 0 Wrong charge in c/er. -melibiose melibiose CHEBI:28053 C05402 0 new chebiID. New keggid -Met-tRNA(Met) Met-tRNA(Met) CHEBI:16635 C02430 0 Wrong charge in c/m. -monolysocardiolipin (1-16:0, 2-16:1, 4-16:1) monolysocardiolipin (1-16:0, 2-16:1, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (1-16:0, 2-16:1, 4-18:1) monolysocardiolipin (1-16:0, 2-16:1, 4-18:1) 0 Wrong charge in mm. -monolysocardiolipin (1-16:0, 2-18:1, 4-16:1) monolysocardiolipin (1-16:0, 2-18:1, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (1-16:0, 2-18:1, 4-18:1) monolysocardiolipin (1-16:0, 2-18:1, 4-18:1) 0 Wrong charge in mm. -monolysocardiolipin (1-16:1, 2-16:1, 4-16:1) monolysocardiolipin (1-16:1, 2-16:1, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (1-16:1, 2-16:1, 4-18:1) monolysocardiolipin (1-16:1, 2-16:1, 4-18:1) 0 Wrong charge in mm. -monolysocardiolipin (1-16:1, 2-18:1, 4-16:1) monolysocardiolipin (1-16:1, 2-18:1, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (1-16:1, 2-18:1, 4-18:1) monolysocardiolipin (1-16:1, 2-18:1, 4-18:1) 0 Wrong charge in mm. -monolysocardiolipin (1-18:0, 2-16:1, 4-16:1) monolysocardiolipin (1-18:0, 2-16:1, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (1-18:0, 2-16:1, 4-18:1) monolysocardiolipin (1-18:0, 2-16:1, 4-18:1) 0 Wrong charge in mm. -monolysocardiolipin (1-18:1, 2-16:1, 4-16:1) monolysocardiolipin (1-18:1, 2-16:1, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (1-18:1, 2-16:1, 4-18:1) monolysocardiolipin (1-18:1, 2-16:1, 4-18:1) 0 Wrong charge in mm. -monolysocardiolipin (2-16:1, 3-16:0, 4-16:1) monolysocardiolipin (2-16:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (2-16:1, 3-16:0, 4-18:1) monolysocardiolipin (2-16:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. -monolysocardiolipin (2-16:1, 3-16:1, 4-16:1) monolysocardiolipin (2-16:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (2-16:1, 3-16:1, 4-18:1) monolysocardiolipin (2-16:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. -monolysocardiolipin (2-16:1, 3-18:0, 4-16:1) monolysocardiolipin (2-16:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (2-16:1, 3-18:1, 4-16:1) monolysocardiolipin (2-16:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (2-18:1, 3-16:0, 4-16:1) monolysocardiolipin (2-18:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (2-18:1, 3-16:0, 4-18:1) monolysocardiolipin (2-18:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. -monolysocardiolipin (2-18:1, 3-16:1, 4-16:1) monolysocardiolipin (2-18:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (2-18:1, 3-16:1, 4-18:1) monolysocardiolipin (2-18:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. -monolysocardiolipin (2-18:1, 3-18:0, 4-16:1) monolysocardiolipin (2-18:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. -monolysocardiolipin (2-18:1, 3-18:1, 4-16:1) monolysocardiolipin (2-18:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. -myo-inositol myo-inositol CHEBI:17268 C00137 0 Wrong CHEBI in erm. Wrong KEGG in erm. -myristate myristate CHEBI:30807 C06424 -1 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. -myristoyl-CoA myristoyl-CoA CHEBI:57385 C02593 -4 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. -NAD NAD CHEBI:57540 C00003 -1 Wrong CHEBI in erm. Wrong KEGG in erm. -NADH NADH CHEBI:57945 C00004 -2 Wrong CHEBI in erm. Wrong KEGG in erm. -NADP(+) NADP(+) CHEBI:58349 C00006 -3 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. -NADPH NADPH CHEBI:57783 C00005 -4 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. -oleate oleate CHEBI:30823 C00712 -1 Wrong CHEBI in e/erm/lp/p/ce/m. Wrong KEGG in e/erm/lp/p/ce/m. -oleoyl-CoA oleoyl-CoA CHEBI:57387 C00510 -4 Wrong CHEBI in erm/lp/mm. Wrong KEGG in erm/lp/mm. -oxygen oxygen CHEBI:15379 C00007 0 Wrong CHEBI in erm. Wrong KEGG in erm. -palmitate palmitate CHEBI:7896 C00249 -1 Wrong CHEBI in erm/lp/mm/ce. Wrong KEGG in erm/lp/mm/ce. -palmitoleate palmitoleate CHEBI:32372 C08362 -1 Wrong CHEBI in erm/lp/ce. Wrong KEGG in erm/lp/ce. -palmitoleoyl-CoA palmitoleoyl-CoA(4-) CHEBI:61540 C21072 -4 wrong chebiID and keggid. update fullname, keggid and full name in chebi -palmitoyl-CoA palmitoyl-CoA CHEBI:57379 C00154 -4 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. -Phe-tRNA(Phe) Phe-tRNA(Phe) CHEBI:29153 C03511 0 Wrong charge in c/m. -phosphate phosphate CHEBI:43474 C00009 -2 Wrong CHEBI in erm/vm/gm/mm/ce. Wrong KEGG in erm/vm/gm/mm/ce. -phosphatidate (1-16:0, 2-16:1) phosphatidate (1-16:0, 2-16:1) CHEBI:73998 -2 new chebiID. Update charge. chebi has some problemthis is a charged chebi id 2- -phosphatidate (1-16:0, 2-18:1) phosphatidate (1-16:0, 2-18:1) CHEBI:64844 C13889 0 new chebiID. new keggid -phosphatidate (1-16:1, 2-16:1) phosphatidate (1-16:1, 2-16:1) CHEBI:75071 0 new chebiID -phosphatidate (1-16:1, 2-18:1) phosphatidate (1-16:1, 2-18:1) 0 "new chebiID. standard fullname: 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphate Synonyms: PA(18:1(9Z)/16:1(9Z));remove duplicated chebiID" -phosphatidate (1-18:0, 2-16:1) phosphatidate (1-18:0, 2-16:1) CHEBI:75073 0 new chebiID -phosphatidate (1-18:0, 2-18:1) phosphatidate (1-18:0, 2-18:1) CHEBI:74847 0 new chebiID -phosphatidate (1-18:1, 2-16:1) phosphatidate (1-18:1, 2-16:1) CHEBI:75074 0 new chebiID -phosphatidate (1-18:1, 2-18:1) phosphatidate (1-18:1, 2-18:1) CHEBI:83775 0 new chebiID -phosphatidylcholine (1-16:0, 2-16:1) phosphatidylcholine (1-16:0, 2-16:1) CHEBI:134592 0 new chebiID -phosphatidylcholine (1-16:0, 2-18:1) phosphatidylcholine (1-16:0, 2-18:1) CHEBI:134594 0 new chebiID -phosphatidylcholine (1-16:1, 2-16:1) phosphatidylcholine (1-16:1, 2-16:1) CHEBI:134637 0 new chebiID -phosphatidylcholine (1-16:1, 2-18:1) phosphatidylcholine (1-16:1, 2-18:1) CHEBI:89668 0 new chebiID -phosphatidylcholine (1-18:0, 2-16:1) phosphatidylcholine (1-18:0, 2-16:1) CHEBI:89972 0 new chebiID -phosphatidylcholine (1-18:0, 2-18:1) phosphatidylcholine (1-18:0, 2-18:1) CHEBI:89679 0 new chebiID -phosphatidylcholine (1-18:1, 2-16:1) phosphatidylcholine (1-18:1, 2-16:1) CHEBI:89506 0 new chebiID -phosphatidylcholine (1-18:1, 2-18:1) phosphatidylcholine (1-18:1, 2-18:1) CHEBI:89504 0 new chebiID -phosphatidylethanolamine (1-16:0, 2-16:1) phosphatidylethanolamine (1-16:0, 2-16:1) CHEBI:136147 0 new chebiID -phosphatidylethanolamine (1-16:0, 2-18:1) phosphatidylethanolamine (1-16:0, 2-18:1) CHEBI:136148 0 new chebiID -phosphatidylethanolamine (1-16:1, 2-16:1) phosphatidylethanolamine (1-16:1, 2-16:1) CHEBI:138792 0 new chebiID -phosphatidylethanolamine (1-16:1, 2-18:1) phosphatidylethanolamine (1-16:1, 2-18:1) CHEBI:90464 0 new chebiID -phosphatidylethanolamine (1-18:0, 2-16:1) phosphatidylethanolamine (1-18:0, 2-16:1) CHEBI:136155 0 new chebiID. CHEBI:136155 for phosphatidylethanolamine (16:1/18:0). has charge of 0 -phosphatidylethanolamine (1-18:0, 2-18:1) phosphatidylethanolamine (1-18:0, 2-18:1) CHEBI:136162 0 new chebiID -phosphatidylethanolamine (1-18:1, 2-16:1) phosphatidylethanolamine (1-18:1, 2-16:1) CHEBI:82837 0 new chebiID -phosphatidylethanolamine (1-18:1, 2-18:1) phosphatidylethanolamine (1-18:1, 2-18:1) CHEBI:136170 0 new chebiID -phosphatidylglycerol (1-16:0, 2-16:1) phosphatidylglycerol (1-16:0, 2-16:1) CHEBI:136224 0 new chebiID. CHEBI:17517 for phosphatidylglycerol. has charge of -1 -phosphatidylglycerol (1-16:0, 2-18:1) phosphatidylglycerol (1-16:0, 2-18:1) CHEBI:34080 C13833 0 new keggid -phosphatidylglycerol (1-16:1, 2-16:1) phosphatidylglycerol (1-16:1, 2-16:1) 0 Wrong charge in mm. -phosphatidylglycerol (1-16:1, 2-18:1) phosphatidylglycerol (1-16:1, 2-18:1) CHEBI:89398 0 new chebiID -phosphatidylglycerol (1-18:0, 2-16:1) phosphatidylglycerol (1-18:0, 2-16:1) CHEBI:89270 0 new chebiID -phosphatidylglycerol (1-18:1, 2-16:1) phosphatidylglycerol (1-18:1, 2-16:1) CHEBI:89093 0 new chebiID -phosphatidyl-L-serine (1-16:0, 2-16:1) phosphatidyl-L-serine (1-16:0, 2-16:1) CHEBI:89824 0 new chebiID. CHEBI:18303 for phosphatidyl-L-serine -phosphatidyl-L-serine (1-16:0, 2-18:1) phosphatidyl-L-serine (1-16:0, 2-18:1) CHEBI:134541 0 new chebiID -phosphatidyl-L-serine (1-16:1, 2-16:1) phosphatidyl-L-serine (1-16:1, 2-16:1) 0 Wrong charge in erm/mm/gm/vm/ce. -phosphatidyl-L-serine (1-16:1, 2-18:1) phosphatidyl-L-serine (1-16:1, 2-18:1) CHEBI:90032 0 new chebiID -phosphatidyl-L-serine (1-18:0, 2-16:1) phosphatidyl-L-serine (1-18:0, 2-16:1) CHEBI:90036 0 new chebiID -phosphatidyl-L-serine (1-18:0, 2-18:1) phosphatidyl-L-serine (1-18:0, 2-18:1) CHEBI:90433 0 new chebiID -phosphatidyl-L-serine (1-18:1, 2-16:1) phosphatidyl-L-serine (1-18:1, 2-16:1) CHEBI:75101 0 new chebiID -phosphatidyl-L-serine (1-18:1, 2-18:1) phosphatidyl-L-serine (1-18:1, 2-18:1) CHEBI:60568 0 new chebiID -phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-16:1) phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-16:1) 0 Wrong charge in erm. -phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-18:1) phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-18:1) 0 Wrong charge in erm. -phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-16:1) phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-16:1) 0 Wrong charge in erm. -phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-18:1) phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-18:1) 0 Wrong charge in erm. -phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-16:1) phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-16:1) 0 Wrong charge in erm. -phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-18:1) phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-18:1) 0 Wrong charge in erm. -phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-16:1) phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-16:1) 0 Wrong charge in erm. -phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-18:1) phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-18:1) CHEBI:85963 0 new chebiID. CHEBI:85963 for 1.2-dioleoyl-sn-glycero-3-phospho-N.N-dimethylethanolamine. PE-NMe2(18:1/18:1) has charge of 0 -phosphatidyl-N-methylethanolamine (1-16:0, 2-16:1) phosphatidyl-N-methylethanolamine (1-16:0, 2-16:1) 0 Wrong charge in erm. -phosphatidyl-N-methylethanolamine (1-16:0, 2-18:1) phosphatidyl-N-methylethanolamine (1-16:0, 2-18:1) 0 Wrong charge in erm. -phosphatidyl-N-methylethanolamine (1-16:1, 2-16:1) phosphatidyl-N-methylethanolamine (1-16:1, 2-16:1) 0 Wrong charge in erm. -phosphatidyl-N-methylethanolamine (1-16:1, 2-18:1) phosphatidyl-N-methylethanolamine (1-16:1, 2-18:1) 0 Wrong charge in erm. -phosphatidyl-N-methylethanolamine (1-18:0, 2-16:1) phosphatidyl-N-methylethanolamine (1-18:0, 2-16:1) 0 Wrong charge in erm. -phosphatidyl-N-methylethanolamine (1-18:0, 2-18:1) phosphatidyl-N-methylethanolamine (1-18:0, 2-18:1) 0 Wrong charge in erm. -phosphatidyl-N-methylethanolamine (1-18:1, 2-16:1) phosphatidyl-N-methylethanolamine (1-18:1, 2-16:1) 0 Wrong charge in erm. -phosphatidyl-N-methylethanolamine (1-18:1, 2-18:1) phosphatidyl-N-methylethanolamine (1-18:1, 2-18:1) CHEBI:85962 0 new chebiID. CHEBI:85962 for 1.2-dioleoyl-sn-glycero-3-phospho-N-methylethanolamine. PE-NMe(18:1/18:1) has charge of 0 -prenyl diphosphate prenyl diphosphate(3-) CHEBI:57623 C00235 -3 update fullname -Pro-tRNA(Pro) Pro-tRNA(Pro) CHEBI:29154 C02702 0 Wrong charge in c. -raffinose raffinose CHEBI:16634 C00492 0 new chebiID. New keggid -S(8)-aminomethyldihydrolipoylprotein S(8)-aminomethyldihydrolipoylprotein CHEBI:16882 C01242 0 Wrong charge in m. -S-adenosyl-L-homocysteine S-adenosyl-L-homocysteine CHEBI:16680 C00021 0 Wrong CHEBI in erm. Wrong KEGG in erm. -S-adenosyl-L-methionine S-adenosyl-L-methionine CHEBI:15414 C00019 1 Wrong CHEBI in erm. Wrong KEGG in erm. -Ser-tRNA(Ser) Ser-tRNA(Ser) CHEBI:29162 C02553 0 Wrong charge in c. -sn-2-acyl-1-lysophosphatidylinositol (16:1) sn-2-acyl-1-lysophosphatidylinositol (16:1) 0 Wrong charge in erm. -sn-2-acyl-1-lysophosphatidylinositol (18:1) sn-2-acyl-1-lysophosphatidylinositol (18:1) 0 Wrong charge in erm. -sn-glycero-3-phosphocholine sn-glycero-3-phosphocholine CHEBI:16870 C00670 0 Update charge. Wrong standard formula and charge according to the chebiID -sn-glycero-3-phosphoethanolamine sn-glycero-3-phosphoethanolamine CHEBI:16929 C01233 0 new chebiID. New keggid -sn-glycero-3-phosphoserine sn-glycero-3-phosphoserine CHEBI:64945 0 new chebiID. has charge of -1 -stearate stearate CHEBI:25629 C01530 -1 Wrong CHEBI in erm/lp/mm/ce. Wrong KEGG in erm/lp/mm/ce. -stearoyl-CoA stearoyl-CoA CHEBI:57394 C00412 -4 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. -tetracosanoyl-CoA tetracosanoyl-CoA CHEBI:52974 C16529 0 Wrong CHEBI in erm/ce/lp. Wrong KEGG in erm/ce/lp. -Thr-tRNA(Thr) Thr-tRNA(Thr) CHEBI:29163 C02992 0 Wrong charge in c/m. -trans-2,cis-5-dodecadienoyl-CoA trans-2,cis-5-dodecadienoyl-CoA 0 wrong chebiID and keggid. Can't find chebiID according to the fullname -trans-2,cis-5-tetradecadienoyl-CoA trans-2,cis-5-tetradecadienoyl-CoA 0 "wrong chebiID and keggid. CHEBI:72001 for (3E.5Z)-tetradecadienoyl-CoA. Has charge of -4;remove duplicated chebiID" -trans-2,cis-7-hexadecadienoyl-CoA trans-2,cis-7-hexadecadienoyl-CoA CHEBI:88086 0 wrong chebiID and keggid. CHEBI:88086 for (2E.7Z)-hexadecadienoyl-CoA. Has charge of -4 -trans-2,cis-7-tetradecadienoyl-CoA trans-2,cis-7-tetradecadienoyl-CoA CHEBI:88067 0 wrong chebiID and keggid. CHEBI:88067 for (2E.5Z)-tetradecadienoyl-CoA -trans-2,cis-9-hexadecadienoyl-CoA trans-2,cis-9-hexadecadienoyl-CoA CHEBI:76889 0 wrong chebiID and keggid. CHEBI:76889 for (9Z.12Z)-hexadecadienoyl-CoA?? Has charge of -4 -trans-2,cis-9-octadecadienoyl-CoA trans-2,cis-9-octadecadienoyl-CoA CHEBI:15530 C02050 0 wrong chebiID and wrong keggid. CHEBI:15530 for (9Z.12Z)-Octadecadienoyl-CoA linoleoyl-CoA is the standard fullname -trans-2,trans-4-dodecadienoyl-CoA trans-2,trans-4-dodecadienoyl-CoA CHEBI:28002 C05280 0 new chebiID. new keggid. CHEBI:28002 for (3Z.6Z)-dodecadienoyl-CoA has charge of 0 -trans-2,trans-4-tetradecadienoyl-CoA trans-2,trans-4-tetradecadienoyl-CoA CHEBI:88084 0 new chebiID -trans-3,cis-5-dodecadienoyl-CoA trans-3,cis-5-dodecadienoyl-CoA CHEBI:139121 0 new chebiID. Has charge of -4 -trans-3,cis-5-tetradecadienoyl-CoA trans-3,cis-5-tetradecadienoyl-CoA CHEBI:72001 0 new chebiID -trans-but-2-enoyl-ACP trans-but-2-enoyl-ACP CHEBI:132146 0 wrong chebiID and keggid -trans-but-2-enoyl-CoA but-2-enoyl-CoA CHEBI:36926 C00877 0 new keggid, formula & fullname. Wrong chebiID. -trans-docos-2-enoyl-CoA trans-docos-2-enoyl-CoA 0 "Wrong chebiID and keggid. Not standard fullname;remove duplicated chebiID;remove duplicated keggID" -trans-dodec-3-enoyl-CoA trans-dodec-3-enoyl-CoA 0 "new chebiID. new keggid. CHEBI:15471 for trans-dodec-2-enoyl-CoA has charge of 0.;remove duplicated chebiID;remove duplicated keggID" -trans-hex-2-enoyl-ACP trans-hex-2-enoyl-ACP CHEBI:10727 C05748 0 wrong chebiID and keggid -trans-hex-2-enoyl-CoA trans-hex-2-enoyl-CoA CHEBI:28706 C05271 0 wrong chebiID and keggid. update keggid, formula. has formula in charge of -4. -trans-hexacos-2-enoyl-CoA trans-hexacos-2-enoyl-CoA CHEBI:52975 0 Wrong CHEBI in erm. Wrong KEGG in erm. -trans-hexadec-2-enoyl-CoA trans-hexadec-2-enoyl-CoA C05272 0 "Wrong chebiID and keggid;remove duplicated chebiID" -trans-icos-2-enoyl-CoA trans-icos-2-enoyl-CoA 0 Wrong chebiID and keggid. Can't find such a metabolite in chebi -trans-oct-2-enoyl-ACP trans-oct-2-enoyl-ACP C05751 0 wrong chebiID. can't find such a metabolite in chebi. Not standard fullname -trans-oct-2-enoyl-CoA trans-oct-2-enoyl-CoA CHEBI:27537 C05276 0 wrong chebiID and keggid. update keggid, formula. has formula in charge of -4. -trans-octadec-2-enoyl-CoA trans-octadec-2-enoyl-CoA CHEBI:50570 C16218 0 Wrong CHEBI in erm. Wrong KEGG in erm. -trans-tetracos-2-enoyl-CoA trans-tetracos-2-enoyl-CoA CHEBI:75068 0 Wrong chebiID and keggid. Not standard fullname. should be trans-2-tetracosenoyl-CoA has charge of -4 according to YMDB -trans-tetradec-2-enoyl-CoA trans-tetradec-2-enoyl-CoA CHEBI:61405 C05273 -4 Wrong CHEBI in erm. Wrong KEGG in erm. -trans-tetradec-3-enoyl-CoA trans-tetradec-3-enoyl-CoA CHEBI:88083 0 new chebiID. CHEBI:88083 for (3E)-tetradecenoyl-CoA trans-3-tetradecenoyl-CoA has charge of 0 -triglyceride (1-16:0, 2-16:1, 3-16:0) triglyceride (1-16:0, 2-16:1, 3-16:0) CHEBI:85427 0 new chebiID. chebi has some problem. this is 16:0.16:0.16:1 -triglyceride (1-16:0, 2-16:1, 3-16:1) triglyceride (1-16:0, 2-16:1, 3-16:1) CHEBI:89765 0 new chebiID -triglyceride (1-16:0, 2-16:1, 3-18:0) triglyceride (1-16:0, 2-16:1, 3-18:0) CHEBI:89763 0 new chebiID -triglyceride (1-16:0, 2-16:1, 3-18:1) triglyceride (1-16:0, 2-16:1, 3-18:1) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" -triglyceride (1-16:0, 2-18:1, 3-16:0) triglyceride (1-16:0, 2-18:1, 3-16:0) CHEBI:89759 0 new chebiID -triglyceride (1-16:0, 2-18:1, 3-16:1) triglyceride (1-16:0, 2-18:1, 3-16:1) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" -triglyceride (1-16:0, 2-18:1, 3-18:0) triglyceride (1-16:0, 2-18:1, 3-18:0) CHEBI:88998 0 new chebiID -triglyceride (1-16:0, 2-18:1, 3-18:1) triglyceride (1-16:0, 2-18:1, 3-18:1) 0 "new chebiID;remove duplicated chebiID" -triglyceride (1-16:1, 2-16:1, 3-16:0) triglyceride (1-16:1, 2-16:1, 3-16:0) 0 "new chebiID;remove duplicated chebiID" -triglyceride (1-16:1, 2-16:1, 3-16:1) triglyceride (1-16:1, 2-16:1, 3-16:1) CHEBI:75841 0 new chebiID -triglyceride (1-16:1, 2-16:1, 3-18:0) triglyceride (1-16:1, 2-16:1, 3-18:0) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" -triglyceride (1-16:1, 2-16:1, 3-18:1) triglyceride (1-16:1, 2-16:1, 3-18:1) CHEBI:90051 0 new chebiID -triglyceride (1-16:1, 2-18:1, 3-16:0) triglyceride (1-16:1, 2-18:1, 3-16:0) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" -triglyceride (1-16:1, 2-18:1, 3-16:1) triglyceride (1-16:1, 2-18:1, 3-16:1) 0 "new chebiID;remove duplicated chebiID" -triglyceride (1-16:1, 2-18:1, 3-18:0) triglyceride (1-16:1, 2-18:1, 3-18:0) 0 "new chebiID;remove duplicated chebiID" -triglyceride (1-16:1, 2-18:1, 3-18:1) triglyceride (1-16:1, 2-18:1, 3-18:1) CHEBI:90048 0 new chebiID -triglyceride (1-18:0, 2-16:1, 3-16:0) triglyceride (1-18:0, 2-16:1, 3-16:0) 0 "new chebiID;remove duplicated chebiID" -triglyceride (1-18:0, 2-16:1, 3-16:1) triglyceride (1-18:0, 2-16:1, 3-16:1) CHEBI:90053 0 new chebiID -triglyceride (1-18:0, 2-16:1, 3-18:0) triglyceride (1-18:0, 2-16:1, 3-18:0) CHEBI:89958 0 new chebiID -triglyceride (1-18:0, 2-16:1, 3-18:1) triglyceride (1-18:0, 2-16:1, 3-18:1) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" -triglyceride (1-18:0, 2-18:1, 3-16:0) triglyceride (1-18:0, 2-18:1, 3-16:0) CHEBI:89755 0 new chebiID -triglyceride (1-18:0, 2-18:1, 3-16:1) triglyceride (1-18:0, 2-18:1, 3-16:1) 0 "new chebiID;remove duplicated chebiID" -triglyceride (1-18:0, 2-18:1, 3-18:0) triglyceride (1-18:0, 2-18:1, 3-18:0) CHEBI:90305 0 new chebiID. CHEBI:90305 for triacylglycerol 54:1 . has charge of 0 -triglyceride (1-18:0, 2-18:1, 3-18:1) triglyceride (1-18:0, 2-18:1, 3-18:1) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" -triglyceride (1-18:1, 2-16:1, 3-16:0) triglyceride (1-18:1, 2-16:1, 3-16:0) 0 "new chebiID;remove duplicated chebiID" -triglyceride (1-18:1, 2-16:1, 3-16:1) triglyceride (1-18:1, 2-16:1, 3-16:1) 0 "new chebiID;remove duplicated chebiID" -triglyceride (1-18:1, 2-16:1, 3-18:0) triglyceride (1-18:1, 2-16:1, 3-18:0) 0 "new chebiID;remove duplicated chebiID" -triglyceride (1-18:1, 2-16:1, 3-18:1) triglyceride (1-18:1, 2-16:1, 3-18:1) CHEBI:88984 0 new chebiID -triglyceride (1-18:1, 2-18:1, 3-16:0) triglyceride (1-18:1, 2-18:1, 3-16:0) CHEBI:88999 0 new chebiID. chebi has some problem. this is 11z -triglyceride (1-18:1, 2-18:1, 3-16:1) triglyceride (1-18:1, 2-18:1, 3-16:1) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" -triglyceride (1-18:1, 2-18:1, 3-18:0) triglyceride (1-18:1, 2-18:1, 3-18:0) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" -triglyceride (1-18:1, 2-18:1, 3-18:1) triglyceride (1-18:1, 2-18:1, 3-18:1) CHEBI:88970 0 new chebiID. chebi has some problem. this is 11z -tRNA(Arg) tRNA(Arg) CHEBI:29171 C01636 0 New keggid -tRNA(Asn) tRNA(Asn) CHEBI:29172 C01637 0 New keggid -tRNA(Asp) tRNA(Asp) CHEBI:29186 C01638 0 New keggid -tRNA(Glu) tRNA(Glu) CHEBI:29175 C01641 0 New keggid -tRNA(His) tRNA(His) CHEBI:29178 C01643 0 New keggid -tRNA(Ile) tRNA(Ile) CHEBI:29174 C01644 0 New keggid -tRNA(Leu) tRNA(Leu) CHEBI:29169 C01645 0 New keggid -tRNA(Lys) tRNA(Lys) CHEBI:29185 C01646 0 New keggid -tRNA(Met) tRNA(Met) CHEBI:29173 C01647 0 New keggid -tRNA(Phe) tRNA(Phe) CHEBI:29184 C01648 0 New keggid -tRNA(Thr) tRNA(Thr) CHEBI:29180 C01651 0 New keggid -tRNA(Trp) tRNA(Trp) CHEBI:29181 C01652 0 New keggid -tRNA(Tyr) tRNA(Tyr) CHEBI:29182 C00787 0 New keggid -tRNA(Val) tRNA(Val) CHEBI:29183 C01653 0 New keggid -Trp-tRNA(Trp) Trp-tRNA(Trp) CHEBI:29159 C03512 0 Wrong charge in c/m. -TRX1 TRX1 CHEBI:15967 C00342 0 Wrong charge in c/m/n/p. -TRX1 disulphide TRX1 disulphide CHEBI:18191 C00343 0 Wrong charge in c/m/n/p. -TTP thiamine(1+) triphosphate(4-) CHEBI:58938 C03028 -3 update fullname -Tyr-tRNA(Tyr) Tyr-tRNA(Tyr) CHEBI:29161 C02839 0 Wrong charge in c/m. -Val-tRNA(Val) Val-tRNA(Val) CHEBI:29164 C02554 0 Wrong charge in c/m. -zymosterol zymosterol CHEBI:18252 C05437 0 Wrong CHEBI in erm. Wrong KEGG in erm. -zymosteryl oleate zymosteryl oleate CHEBI:52384 0 new chebiID -zymosteryl palmitoleate zymosteryl palmitoleate CHEBI:52385 0 new chebiID -trans-dec-2-enoyl-CoA trans-dec-2-enoyl-CoA C05275 -4 remove duplicated chebiID -trans-dodec-2-enoyl-CoA trans-dodec-2-enoyl-CoA C03221 -4 remove duplicated chebiID +name_original name_correct CHEBI KEGG charge remark +(R)-3-hydroxybutanoyl-CoA (R)-3-hydroxybutanoyl-CoA CHEBI:15452 C03561 0 wrong chebiID and keggid. update keggid, formula. has formula in charge of -4. +(R)-3-hydroxy-cis-dodec-5-enoyl-CoA (R)-3-hydroxy-cis-dodec-5-enoyl-CoA 0 wrong chebiID and keggid. Can't find from database +(R)-3-hydroxy-cis-hexadec-7-enoyl-CoA (R)-3-hydroxy-cis-hexadec-7-enoyl-CoA CHEBI:88087 0 wrong chebiID and keggid. CHEBI:88087 for (3S.7Z)-3-hydroxyhexadecenoyl-CoA +(R)-3-hydroxy-cis-hexadec-9-enoyl-CoA (R)-3-hydroxy-cis-hexadec-9-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:87781 for (3S)-3-hydroxyoleoyl-CoA. (3S.9Z)-3-hydroxyoctadec-9-enoyl-CoA;remove duplicated chebiID" +(R)-3-hydroxy-cis-octadec-9-enoyl-CoA (R)-3-hydroxy-cis-octadec-9-enoyl-CoA CHEBI:87781 0 wrong chebiID and keggid. CHEBI:87781 for (3S)-3-hydroxyoleoyl-CoA. (3S.9Z)-3-hydroxyoctadec-9-enoyl-CoA +(R)-3-hydroxy-cis-tetradec-5-enoyl-CoA (R)-3-hydroxy-cis-tetradec-5-enoyl-CoA CHEBI:88072 0 wrong chebiID and keggid. CHEBI:88072 for (3S.5Z)-3-hydroxytetradec-5-enoyl-CoA +(R)-3-hydroxy-cis-tetradec-7-enoyl-CoA (R)-3-hydroxy-cis-tetradec-7-enoyl-CoA 0 wrong chebiID and keggid. No chebiID. (3S)-Hydroxy-cis-tetradec-7-enoyl-CoA. C35H56N7O18P3S. https://webapps.molecular-networks.com/biopath3/biopath/mols/(3S)-Hydroxy-cis-tetradec-7-enoyl-CoA +(R)-3-hydroxydocosanoyl-CoA (R)-3-hydroxydocosanoyl-CoA CHEBI:76375 -4 wrong chebiID and keggid. Update charge +(R)-3-hydroxyhexanoyl-CoA (R)-3-hydroxyhexanoyl-CoA CHEBI:74474 0 wrong chebiID and keggid +(R)-3-hydroxyicosanoyl-CoA (R)-3-hydroxyicosanoyl-CoA CHEBI:76453 0 wrong chebiID and keggid +(R)-3-hydroxyoctanoyl-CoA (R)-3-hydroxyoctanoyl-CoA CHEBI:28573 C05278 0 wrong chebiID and wrong keggid +(R)-3-hydroxytetracosanoyl-CoA (R)-3-hydroxytetracosanoyl-CoA CHEBI:76463 0 wrong chebiID and keggid +(S)-3-hydroxyhexacosanoyl-CoA (S)-3-hydroxyhexacosanoyl-CoA CHEBI:52976 0 Wrong CHEBI in erm. Wrong KEGG in erm. +(S)-3-hydroxypalmitoyl-CoA (S)-3-hydroxypalmitoyl-CoA CHEBI:27402 C05258 0 Wrong CHEBI in erm. Wrong KEGG in erm. +(S)-3-hydroxytetradecanoyl-CoA (S)-3-hydroxytetradecanoyl-CoA CHEBI:27466 C05260 0 Wrong CHEBI in erm. Wrong KEGG in erm. +1-(sn-glycero-3-phospho)-1D-myo-inositol 1-(sn-glycero-3-phospho)-1D-myo-inositol CHEBI:58444 C01225 -1 Wrong CHEBI in ce. Wrong KEGG in ce. +1,2-diacylglycerol 3-diphosphate (1-16:0, 2-16:1) 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-16:1) 0 Wrong charge in vm/gm. +1,2-diacylglycerol 3-diphosphate (1-16:0, 2-18:1) 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-18:1) CHEBI:34087 C13890 0 new chebiID. new keggid. CHEBI:34087 for 1-O-hexadecanoyl-2-O-[(Z)-octadec-9-enoyl]-sn-glycerol 3-diphosphate has charge of 0 the chain of chebi 34087 is same to this metabolite.Manually calculated based on 1.2-diacylglycerol 3-diphosphate +1,2-diacylglycerol 3-diphosphate (1-16:1, 2-16:1) 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-16:1) 0 Wrong charge in vm/gm. +1,2-diacylglycerol 3-diphosphate (1-16:1, 2-18:1) 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-18:1) 0 Wrong charge in vm/gm. +1,2-diacylglycerol 3-diphosphate (1-18:0, 2-16:1) 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-16:1) 0 Wrong charge in vm/gm. +1,2-diacylglycerol 3-diphosphate (1-18:0, 2-18:1) 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-18:1) 0 Wrong charge in vm/gm. +1,2-diacylglycerol 3-diphosphate (1-18:1, 2-16:1) 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-16:1) 0 Wrong charge in vm/gm. +1,2-diacylglycerol 3-diphosphate (1-18:1, 2-18:1) 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-18:1) 0 Wrong charge in vm/gm. +14-demethyllanosterol 14-demethyllanosterol CHEBI:18364 C05108 0 Wrong CHEBI in e. Wrong KEGG in e. +1-acylglycerophosphocholine (16:0) 1-acylglycerophosphocholine (16:0) 1 Update charge. Manually calculated based on 1-acylglycerophosphocholine(1+) +1-acylglycerophosphocholine (16:1) 1-acylglycerophosphocholine (16:1) 1 Update charge. Manually calculated based on 1-acylglycerophosphocholine(1+) +1-acylglycerophosphocholine (18:0) 1-acylglycerophosphocholine (18:0) 1 Update charge. Manually calculated based on 1-acylglycerophosphocholine(1+) +1-acylglycerophosphocholine (18:1) 1-acylglycerophosphocholine (18:1) 1 Update charge. Manually calculated based on 1-acylglycerophosphocholine(1+) +1-acylglycerophosphoethanolamine (16:0) 1-acylglycerophosphoethanolamine (16:0) CHEBI:90452 0 new chebiID. CHEBI:90452 for lysophosphatidylethanolamine 16:0. has charge of 0. based on chebi:136148Manually calculated based on 1-O-acylglycerophosphoethanolamine +1-acylglycerophosphoethanolamine (16:1) 1-acylglycerophosphoethanolamine (16:1) 0 Wrong charge in erm/ce/lp. +1-acylglycerophosphoethanolamine (18:0) 1-acylglycerophosphoethanolamine (18:0) CHEBI:64576 0 new chebiID. CHEBI:64576 for lysophosphatidylethanolamine 18:0. has charge of 0. Manually calculated based on 1-O-acylglycerophosphoethanolamine +1-acylglycerophosphoethanolamine (18:1) 1-acylglycerophosphoethanolamine (18:1) CHEBI:64575 0 new chebiID. CHEBI:64575 for lysophosphatidylethanolamine 18:1. has charge of 0. Manually calculated based on 1-O-acylglycerophosphoethanolamine +1-acylglycerophosphoinositol (16:0) 1-acylglycerophosphoinositol (16:0) CHEBI:73218 0 new chebiID. CHEBI:73218 for 1-hexadecanoyl-sn-glycero-3-phospho-D-myo-inositol PI(16:0/0:0) has new chebiID. charge of 0. Manually calculated based on 1-acylglycerophosphoinositol +1-acylglycerophosphoinositol (16:1) 1-acylglycerophosphoinositol (16:1) CHEBI:138108 0 new chebiID. CHEBI:138108 for 2-palmitoleoyl-sn-glycero-3-phospho-D-myo-inositol. has charge of 0.Manually calculated based on 1-acylglycerophosphoinositol +1-acylglycerophosphoinositol (18:0) 1-acylglycerophosphoinositol (18:0) CHEBI:83054 0 new chebiID. CHEBI:83054 for 1-stearoyl-sn-glycero-3-phospho-1D-myo-inositol PI(18:0/0:0). has charge of 0. Manually calculated based on 1-acylglycerophosphoinositol +1-acylglycerophosphoinositol (18:1) 1-acylglycerophosphoinositol (18:1) CHEBI:82753 0 new chebiID. CHEBI:82753 for 1-oleoyl-sn-glycero-3-phospho-D-myo-inositol PI(18:1/0:0). has charge of 0. Manually calculated based on 1-acylglycerophosphoinositol +1-acylglycerophosphoserine (16:0) 1-acylglycerophosphoserine (16:0) 0 Wrong charge in ce. +1-acylglycerophosphoserine (16:1) 1-acylglycerophosphoserine (16:1) 0 Wrong charge in ce. +1-acylglycerophosphoserine (18:0) 1-acylglycerophosphoserine (18:0) 0 Wrong charge in ce. +1-acylglycerophosphoserine (18:1) 1-acylglycerophosphoserine (18:1) 0 Wrong charge in ce. +1-acyl-sn-glycerol 3-phosphate (16:0) 1-acyl-sn-glycerol 3-phosphate (16:0) CHEBI:15799 C04036 0 new chebiID. new keggid +1-acyl-sn-glycerol 3-phosphate (16:1) 1-acyl-sn-glycerol 3-phosphate (16:1) CHEBI:75070 0 new chebiID +1-acyl-sn-glycerol 3-phosphate (18:0) 1-acyl-sn-glycerol 3-phosphate (18:0) CHEBI:74850 0 new chebiID +1-acyl-sn-glycerol 3-phosphate (18:1) 1-acyl-sn-glycerol 3-phosphate (18:1) CHEBI:62837 0 new chebiID +1D-myo-inositol 1,4,5-trisphosphate 1D-myo-inositol 1,4,5-trisphosphate CHEBI:203600 C01245 -6 Wrong CHEBI in c. Wrong KEGG in c. +1-monoglyceride (16:0) 1-monoglyceride (16:0) CHEBI:134127 0 new chebiID +1-monoglyceride (16:1) 1-monoglyceride (16:1) CHEBI:134128 0 new chebiID +1-monoglyceride (18:0) 1-monoglyceride (18:0) CHEBI:134129 0 new chebiID +1-monoglyceride (18:1) 1-monoglyceride (18:1) CHEBI:134130 0 new chebiID +1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) CHEBI:88396 0 new chebiID. CHEBI:16749 for 1-phosphatidyl-1D-myo-inositol. has charge of -1 +1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) CHEBI:73215 C13888 0 new chebiID. new keggid +1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1) 0 Wrong charge in erm/ce/vm/gm/n/c. +1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1) CHEBI:88562 0 new chebiID +1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) CHEBI:88557 0 new chebiID +1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) CHEBI:77346 0 new chebiID +1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1) CHEBI:88626 0 new chebiID +1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1) CHEBI:88612 0 new chebiID +1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1) 0 Wrong charge in vm/ce/c. +1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1) 0 Wrong charge in vm/ce/c. +1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1) 0 Wrong charge in vm/ce/c. +1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1) 0 Wrong charge in vm/ce/c. +1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1) 0 Wrong charge in vm/ce/c. +1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1) 0 Wrong charge in vm/ce/c. +1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1) 0 Wrong charge in vm/ce/c. +1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1) 0 Wrong charge in vm/ce/c. +1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1) 0 Wrong charge in vm/ce/c/erm/gm. +1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1) 0 Wrong charge in vm/ce/c/erm/gm. +1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1) 0 Wrong charge in vm/ce/c/erm/gm. +1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1) 0 Wrong charge in vm/ce/c/erm/gm. +1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1) 0 Wrong charge in vm/ce/c/erm/gm. +1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1) CHEBI:77347 0 new chebiID. CHEBI:77347 for 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate Phosphatidylinositol Phosphate(18:0/18:1). has charge of 0. in structure 3-phosphate is like 5 -phosphate in Benzene ring. Manually calculated based on 1-phosphatidyl-1D-myo-inositol 3-phosphate +1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1) 0 Wrong charge in vm/ce/c/erm/gm. +1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1) CHEBI:77344 0 new chebiID. CHEBI:7734 for1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate Phosphatidylinositol Phosphate(18:0/18:2). has charge of 0. Manually calculated based on 1-phosphatidyl-1D-myo-inositol 3-phosphate +1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1) 0 Wrong charge in n/ce/c/erm. +1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1) 0 Wrong charge in n/ce/c/erm. +1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1) 0 Wrong charge in n/ce/c/erm. +1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1) 0 Wrong charge in n/ce/c/erm. +1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1) 0 Wrong charge in n/ce/c/erm. +1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1) CHEBI:77279 0 new chebiID. CHEBI:77279 for 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-1D-myo-inositol 4.5-biphosphate. has charge of 0. Manually calculated based on 1-phosphatidyl-1D-myo-inositol 4.5-phosphate +1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1) 0 Wrong charge in n/ce/c/erm. +1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1) 0 Wrong charge in n/ce/c/erm. +1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1) 0 Wrong charge in ce/vm/gm/n/c/erm. +1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1) 0 Wrong charge in ce/vm/gm/n/c/erm. +1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1) 0 Wrong charge in ce/vm/gm/n/c/erm. +1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1) 0 Wrong charge in ce/vm/gm/n/c/erm. +1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1) 0 Wrong charge in ce/vm/gm/n/c/erm. +1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1) CHEBI:77277 0 new chebiID. CHEBI:77277 for 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate. has charge of 0. Manually calculated based on 1-phosphatidyl-1D-myo-inositol 4-phosphate +1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1) 0 Wrong charge in ce/vm/gm/n/c/erm. +1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1) 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1) 0 Wrong charge in ce/vm/gm/n/c/erm. +2-isopropylmalate 2-isopropylmalate CHEBI:28107 C02504 -2 Wrong chebiID. +3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-16:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-16:1) 0 Wrong charge in mm. +3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1) 0 Wrong charge in mm. +3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-16:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-16:1) 0 Wrong charge in mm. +3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-18:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-18:1) 0 Wrong charge in mm. +3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:0, 2-16:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:0, 2-16:1) 0 Wrong charge in mm. +3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:1, 2-16:1) 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:1, 2-16:1) 0 Wrong charge in mm. +3-hydroxybutanoyl-ACP 3-hydroxybutanoyl-ACP C04618 0 Wrong chebiID and keggid. Can't find such a metabolite in chebi +3-hydroxydocosanoyl-CoA 3-hydroxydocosanoyl-CoA CHEBI:52325 0 wrong chebiID and keggid +3-hydroxyhexanoyl-ACP 3-hydroxyhexanoyl-ACP CHEBI:326 C05747 0 wrong chebiID and fullname and keggid +3-hydroxyicosanoyl-CoA 3-hydroxyicosanoyl-CoA CHEBI:52324 0 wrong chebiID and charge and keggid +3-hydroxyoctadecanoyl-CoA 3-hydroxyoctadecanoyl-CoA CHEBI:50583 C16217 0 Wrong CHEBI in erm. Wrong KEGG in erm. +3-hydroxyoctanoyl-ACP 3-hydroxyoctanoyl-ACP CHEBI:80387 C16220 0 wrong chebiID and keggid. Not standard fullname +3-hydroxytetracosanoyl-CoA 3-hydroxytetracosanoyl-CoA CHEBI:52326 0 wrong chebiID and keggid +3-oxo-cis-dodec-5-enoyl-CoA 3-oxo-cis-dodec-5-enoyl-CoA 0 wrong chebiID and keggid. PubChem CID: 90658857 for (5E)-3-oxo-dodecenoyl-CoA. https://pubchem.ncbi.nlm.nih.gov/compound/90658857#section=Top C33H50N7O18P3S(-4) +3-oxo-cis-hexadec-7-enoyl-CoA 3-oxo-cis-hexadec-7-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:88008 for (7Z)-hexadecenoyl-CoA;remove duplicated chebiID" +3-oxo-cis-hexadec-9-enoyl-CoA 3-oxo-cis-hexadec-9-enoyl-CoA CHEBI:53152 0 wrong chebiID and keggid. CHEBI:53152 for palmitoleoyl-CoA cis-9-hexadecenoyl-CoA +3-oxo-cis-octadec-9-enoyl-CoA 3-oxo-cis-octadec-9-enoyl-CoA CHEBI:78146 0 wrong chebiID and keggID. CHEBI:78146 for trans-9-octadecenoyl-CoA. Has charge of -4 +3-oxo-cis-tetradec-5-enoyl-CoA 3-oxo-cis-tetradec-5-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:70712 for (5Z)-tetradecenoyl-CoA. cis-5-tetradecenoyl-CoA;remove duplicated chebiID" +3-oxo-cis-tetradec-7-enoyl-CoA 3-oxo-cis-tetradec-7-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:62014 for cis-tetradec-3-enoyl-CoA. No cis-tetradec-7-enoyl-CoA;remove duplicated chebiID" +3-oxodocosanoyl-CoA 3-oxodocosanoyl-CoA CHEBI:52328 0 wrong chebiID and keggid +3-oxohexacosanoyl-CoA 3-oxohexacosanoyl-CoA CHEBI:52977 0 Wrong CHEBI in erm. Wrong KEGG in erm. +3-oxo-hexanoyl-ACP 3-oxo-hexanoyl-ACP CHEBI:1642 C05746 0 wrong chebiID and keggid +3-oxohexanoyl-CoA 3-oxohexanoyl-CoA CHEBI:27648 C05269 0 wrong chebiID and keggid. update keggid, formula. has formula in charge of -4. +3-oxoicosanoyl-CoA 3-oxoicosanoyl-CoA CHEBI:52327 0 wrong chebiID and keggid +3-oxooctadecanoyl-CoA 3-oxooctadecanoyl-CoA CHEBI:50571 C16216 0 Wrong CHEBI in erm. Wrong KEGG in erm. +3-oxo-octanoyl-ACP 3-oxo-octanoyl-ACP CHEBI:1646 C05750 0 wrong chebiID and keggid +3-oxooctanoyl-CoA 3-oxooctanoyl-CoA CHEBI:28264 C05267 0 wrong chebiID and keggid. update keggid, formula. has formula in charge of -4. +3-oxopalmitoyl-CoA 3-oxopalmitoyl-CoA CHEBI:57349 C05259 -4 Wrong CHEBI in erm. Wrong KEGG in erm. +3-oxotetracosanoyl-CoA 3-oxotetracosanoyl-CoA CHEBI:52329 0 wrong chebiID and keggid +3-oxotetradecanoyl-CoA 3-oxotetradecanoyl-CoA CHEBI:28726 C05261 0 Wrong CHEBI in erm. Wrong KEGG in erm. +3-phosphoglycerate 3-phosphonato-D-glycerate(3-) CHEBI:58272 C00197 -3 update fullname. the old keggid is for the molecular form +4beta-methylzymosterol-4alpha-carboxylic acid 4beta-methylzymosterol-4alpha-carboxylic acid CHEBI:50591 C15808 0 New keggid +6-(alpha-D-glucosaminyl)-O-acyl-1-phosphatidyl-1D-myo-inositol 6-(alpha-D-glucosaminyl)-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53055 0 Wrong charge in er. +6-[6-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-2-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-alpha-2-(2-aminoethylphosphoryl)mannosyl-(1->4)-alpha-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol 6-[6-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-2-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-alpha-2-(2-aminoethylphosphoryl)mannosyl-(1->4)-alpha-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53060 0 Wrong charge in er. +6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol 6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53056 0 Wrong charge in er. +6-O-{2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol 6-O-{2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53057 0 Wrong charge in er. +6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53059 0 Wrong charge in er. +6-O-{alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol 6-O-{alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol CHEBI:53058 0 Wrong charge in er. +acetoacetyl-ACP acetoacetyl-ACP CHEBI:2393 C05744 0 wrong cheibID and keggid +acetoacetyl-CoA acetoacetyl-CoA CHEBI:57286 C00332 -4 Wrong CHEBI in p. Wrong KEGG in p. +ACP1 ACP1 CHEBI:18359 C00229 0 Wrong chebiID. Wrong full name. should be: holo-[acyl-carrier protein] +acylglycerone phosphate (16:0) acylglycerone phosphate (16:0) CHEBI:17868 C01192 0 new chebiID. new keggid +acylglycerone phosphate (16:1) acylglycerone phosphate (16:1) CHEBI:74694 -2 new chebiID. Update charge. CHEBI:74694 for 1-palmitoleoyl-sn-glycerol 3-phosphate(2-) +acylglycerone phosphate (18:0) acylglycerone phosphate (18:0) CHEBI:36476 C03805 -2 new chebiID. new keggid. Update charge. chebi has some problem.this is a charged chebi id 2- +acylglycerone phosphate (18:1) acylglycerone phosphate (18:1) CHEBI:36475 C03630 0 new chebiID. new keggid +ADP ADP CHEBI:456216 C00008 -3 Wrong CHEBI in ce/vm/gm. Wrong KEGG in ce/vm/gm. +Ala-tRNA(Ala) Ala-tRNA(Ala) CHEBI:17732 C00886 0 Wrong charge in c. +alpha-D-ribose 1-phosphate alpha-D-ribose 1-phosphate(2-) CHEBI:57720 C00620 -2 update fullname and kegg id. the new keggid is for the molecular form +AMP AMP CHEBI:456215 C00020 -2 Wrong CHEBI in erm/lp/ce. Wrong KEGG in erm/lp/ce. +arachidate arachidate CHEBI:32360 -1 Wrong chebiID and keggid. Update formula and charge +Arg-tRNA(Arg) Arg-tRNA(Arg) CHEBI:18366 C02163 0 Wrong charge in c/m. +Asn-tRNA(Asn) Asn-tRNA(Asn) CHEBI:29265 C03402 0 Wrong charge in c/m. +Asp-tRNA(Asp) Asp-tRNA(Asp) CHEBI:29158 C02984 0 Wrong charge in c/m. +ATP ATP CHEBI:30616 C00002 -4 Wrong CHEBI in erm/lp/ce/vm/gm. Wrong KEGG in erm/lp/ce/vm/gm. +behenate behenate CHEBI:23858 C08281 -1 wrong chebiID and keggid. Update charge +biomass biomass 0 Wrong charge in c. +butanoyl-ACP butanoyl-ACP CHEBI:3247 C05745 0 wrong chebiID and keggid. Not standard fullname +butanoyl-CoA butanoyl-CoA CHEBI:15517 C00136 0 wrong chebiID and keggid. Has charge of -4 +butyrate butyrate CHEBI:17968 C00246 -1 wrong chebiID and keggid. update keggid, formula and charge +carbon dioxide carbon dioxide CHEBI:16526 C00011 0 Wrong CHEBI in erm/mm/gm/vm. Wrong KEGG in erm/mm/gm/vm. +cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1) cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1) cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1) cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1) cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1) cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1) cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-18:1) cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-16:1) cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-18:1) cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1) cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1) cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-18:1, 3-18:0, 4-16:1) cardiolipin (1-16:0, 2-18:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1) cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-18:1) cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1) cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1) cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1) cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1) CHEBI:104873 0 new chebiID. CHEBI:104873 for tetrahexadec-9-enoyl cardiolipin CL(16:1/16:1/16:1/16:1). has charge of 0. Manually calculated based on cardiolipin +cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1) cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1) cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1) cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-18:1) cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1) cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1) cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1) cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1) cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1) cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1) cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-18:1) cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-16:1) cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-18:1) cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1) cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1) cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-18:0, 2-16:1, 3-18:0, 4-16:1) cardiolipin (1-18:0, 2-16:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1) cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-18:1) cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1) cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1) cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1) cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1) cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1) cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1) cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-18:1) cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1) cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1) cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-16:1) cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-18:1) cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1) cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. +cardiolipin (1-18:1, 2-18:1, 3-18:1, 4-16:1) cardiolipin (1-18:1, 2-18:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. +CDP CDP CHEBI:58069 C00112 -3 Wrong CHEBI in erm. Wrong KEGG in erm. +CDP-choline CDP-choline CHEBI:16436 C00307 0 Wrong CHEBI in erm. Wrong KEGG in erm. +CDP-diacylglycerol (1-16:0, 2-16:1) CDP-diacylglycerol (1-16:0, 2-16:1) 0 Wrong charge in erm/mm. +CDP-diacylglycerol (1-16:0, 2-18:1) CDP-diacylglycerol (1-16:0, 2-18:1) CHEBI:34077 C13892 0 new keggid +CDP-diacylglycerol (1-16:1, 2-16:1) CDP-diacylglycerol (1-16:1, 2-16:1) CHEBI:104012 0 new chebiID +CDP-diacylglycerol (1-16:1, 2-18:1) CDP-diacylglycerol (1-16:1, 2-18:1) 0 Wrong charge in erm/mm. +CDP-diacylglycerol (1-18:0, 2-16:1) CDP-diacylglycerol (1-18:0, 2-16:1) 0 No chebi id found. ECMDB23374 +CDP-diacylglycerol (1-18:0, 2-18:1) CDP-diacylglycerol (1-18:0, 2-18:1) 0 Wrong charge in erm. +CDP-diacylglycerol (1-18:1, 2-16:1) CDP-diacylglycerol (1-18:1, 2-16:1) 0 Wrong charge in erm/mm. +CDP-diacylglycerol (1-18:1, 2-18:1) CDP-diacylglycerol (1-18:1, 2-18:1) CHEBI:104362 0 new chebiID. CHEBI:104362 for 1.2-dioctadec-11-enoyl-sn-glycero-3-cytidine 5'-diphosphate CDP-DG(18:1/18:1) +CDP-ethanolamine CDP-ethanolamine CHEBI:57876 C00570 -1 Wrong CHEBI in erm. Wrong KEGG in erm. +cerotic acid cerotic acid CHEBI:31013 -1 Wrong CHEBI in ce/erm/lp. Wrong KEGG in ce/erm/lp. +cis-dec-3-enoyl-CoA cis-dec-3-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:10723 for trans-dec-2-enoyl-CoA;remove duplicated chebiID;remove duplicated keggID" +cis-dodec-3-enoyl-CoA cis-dodec-3-enoyl-CoA CHEBI:27989 0 "wrong chebiID and keggid;remove duplicated keggID" +cis-dodec-5-enoyl-CoA cis-dodec-5-enoyl-CoA 0 "wrong chebiID and keggid. CHEBI:27989 for cis-dodec-3-enoyl-CoA;remove duplicated chebiID;remove duplicated keggID" +cis-hexadec-7-enoyl-CoA cis-hexadec-7-enoyl-CoA CHEBI:88008 0 wrong chebiID and keggid +cis-tetradec-5-enoyl-CoA cis-tetradec-5-enoyl-CoA CHEBI:70712 0 wrong chebiID and keggid +cis-tetradec-7-enoyl-CoA cis-tetradec-7-enoyl-CoA 0 "Wrong chebiID and keggid .CHEBI:62014 for cis-tetradec-3-enoyl-CoA;remove duplicated chebiID" +CMP CMP CHEBI:60377 C00055 -2 Wrong CHEBI in erm/mm. Wrong KEGG in erm/mm. +coenzyme A coenzyme A CHEBI:57287 C00010 -4 Wrong CHEBI in erm/ce/mm. Wrong KEGG in erm/ce/mm. +CTP CTP CHEBI:37563 C00063 -4 Wrong CHEBI in erm/mm. Wrong KEGG in erm/mm. +Cys-tRNA(Cys) Cys-tRNA(Cys) CHEBI:29152 C03125 0 Wrong charge in c. +diglyceride (1-16:0, 2-16:1) diglyceride (1-16:0, 2-16:1) CHEBI:82929 0 new chebiID +diglyceride (1-16:0, 2-18:1) diglyceride (1-16:0, 2-18:1) CHEBI:88454 0 new chebiID. chebi has some problem. this is 11z +diglyceride (1-16:1, 2-16:1) diglyceride (1-16:1, 2-16:1) CHEBI:84417 0 new chebiID +diglyceride (1-16:1, 2-18:1) diglyceride (1-16:1, 2-18:1) CHEBI:88500 0 new chebiID +diglyceride (1-18:0, 2-16:1) diglyceride (1-18:0, 2-16:1) CHEBI:88527 0 new chebiID +diglyceride (1-18:0, 2-18:1) diglyceride (1-18:0, 2-18:1) CHEBI:75468 0 new chebiID +diglyceride (1-18:1, 2-16:1) diglyceride (1-18:1, 2-16:1) CHEBI:89229 0 new chebiID +diglyceride (1-18:1, 2-18:1) diglyceride (1-18:1, 2-18:1) CHEBI:52333 0 new chebiID +dihydrolipoylprotein dihydrolipoylprotein CHEBI:16194 C02972 0 Wrong charge in m. +dihydroxyacetone phosphate dihydroxyacetone phosphate CHEBI:57642 C00111 -2 Wrong CHEBI in erm. Wrong KEGG in erm. +diphosphate diphosphate CHEBI:33019 C00013 -3 Wrong CHEBI in erm/ce/mm. Wrong KEGG in erm/ce/mm. +D-mannose 6-phosphate D-mannose 6-phosphate CHEBI:17369 C00275 0 Wrong charge in c. +docosanoyl-CoA docosanoyl-CoA CHEBI:65088 C16528 0 Wrong chebiID and keggid. Has charge of -4 +episterol episterol CHEBI:23929 C15777 0 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. +episteryl oleate episteryl oleate CHEBI:52375 0 new chebiID +episteryl palmitoleate episteryl palmitoleate CHEBI:52376 0 new chebiID +ergosta-5,7,22,24(28)-tetraen-3beta-ol ergosta-5,7,22,24(28)-tetraen-3beta-ol CHEBI:18249 C05440 0 Wrong CHEBI in e. Wrong KEGG in e. +ergosta-5,7,24(28)-trien-3beta-ol ergosta-5,7,24(28)-trien-3beta-ol CHEBI:52972 C15780 0 new keggid +ergosterol ergosterol CHEBI:16933 C01694 0 Wrong CHEBI in erm. Wrong KEGG in erm. +ergosteryl oleate ergosteryl oleate CHEBI:52377 0 new chebiID +ergosteryl palmitoleate ergosteryl palmitoleate CHEBI:52378 0 new chebiID +fecosterol fecosterol CHEBI:17038 C04525 0 Wrong CHEBI in erm. Wrong KEGG in erm. +fecosteryl oleate fecosteryl oleate CHEBI:52379 0 new chebiID +fecosteryl palmitoleate fecosteryl palmitoleate CHEBI:52380 0 new chebiID +ferricytochrome c ferricytochrome c CHEBI:15991 C00125 0 Wrong charge in m. +ferrocytochrome c ferrocytochrome c CHEBI:16928 C00126 0 Wrong charge in m. +fMet-tRNA(fMet) fMet-tRNA(fMet) CHEBI:17119 C03294 0 Wrong charge in m. +Gln-tRNA(Gln) Gln-tRNA(Gln) CHEBI:29166 C02282 0 Wrong charge in c. +Glu-tRNA(Glu) Glu-tRNA(Glu) CHEBI:29157 C02987 0 Wrong charge in c/m. +glycerol glycerol CHEBI:17754 C00116 0 Wrong CHEBI in lp. Wrong KEGG in lp. +glycerol 3-phosphate glycerol 3-phosphate CHEBI:57597 C00093 -2 Wrong CHEBI in erm/mm. Wrong KEGG in erm/mm. +glycogen glycogen CHEBI:28087 C00182 0 Wrong charge in c/v. +Gly-tRNA(Gly) Gly-tRNA(Gly) CHEBI:29156 C02412 0 Wrong charge in c. +H+ H+ CHEBI:24636 C00080 1 Wrong CHEBI in erm/mm/gm/vm. Wrong KEGG in erm/mm/gm/vm. +H2O H2O CHEBI:15377 C00001 0 Wrong CHEBI in erm/vm/gm/mm/ce/lp. Wrong KEGG in erm/vm/gm/mm/ce/lp. +heme a heme a CHEBI:24479 C15670 0 Wrong CHEBI in c. Wrong KEGG in c. Wrong charge in m/c. +heme o heme o CHEBI:24480 C15672 0 Wrong charge in m. +hexacosanoyl-CoA hexacosanoyl-CoA CHEBI:52966 0 Wrong CHEBI in erm/ce/lp. Wrong KEGG in erm/ce/lp. +hexanoate hexanoate CHEBI:17120 C01585 -1 Wrong chebiID and keggid. update keggid, formula and charge +hexanoyl-ACP hexanoyl-ACP CHEBI:5704 C05749 0 wrong chebiID and keggid +hexanoyl-CoA hexanoyl-CoA CHEBI:27540 C05270 0 wrong chebiID and keggid. +His-tRNA(His) His-tRNA(His) CHEBI:29155 C02988 0 Wrong charge in c/m. +icosanoyl-CoA icosanoyl-CoA CHEBI:15527 C02041 0 Wrong chebiID and keggid +Ile-tRNA(Ile) Ile-tRNA(Ile) CHEBI:29160 C03127 0 Wrong charge in c/m. +iron iron(2+) CHEBI:29033 C14818 2 update fullname +lanosterol lanosterol CHEBI:16521 C01724 0 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. +lanosteryl oleate lanosteryl oleate CHEBI:52382 0 new chebiID +lanosteryl palmitoleate lanosteryl palmitoleate CHEBI:52383 0 new chebiID +laurate laurate CHEBI:18262 C02679 -1 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. +lauroyl-CoA lauroyl-CoA CHEBI:57375 C01832 -4 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. +Leu-tRNA(Leu) Leu-tRNA(Leu) CHEBI:16624 C02047 0 Wrong charge in c/m. +lignoceric acid lignoceric acid CHEBI:31014 C08320 -1 Wrong CHEBI in ce/erm/lp. Wrong KEGG in ce/erm/lp. +lipid lipid CHEBI:18059 C01356 0 Wrong charge in c. +lipoylprotein lipoylprotein CHEBI:15804 C02051 0 Wrong charge in m. +L-serine L-serine CHEBI:17115 C00065 0 Wrong CHEBI in erm. Wrong KEGG in erm. +Lys-tRNA(Lys) Lys-tRNA(Lys) CHEBI:16047 C01931 0 Wrong charge in c/m. +malonyl-CoA malonyl-CoA CHEBI:57384 C00083 -5 Wrong CHEBI in erm. Wrong KEGG in erm. +mannan mannan CHEBI:28808 C00464 0 Wrong charge in c/er. +melibiose melibiose CHEBI:28053 C05402 0 new chebiID. New keggid +Met-tRNA(Met) Met-tRNA(Met) CHEBI:16635 C02430 0 Wrong charge in c/m. +monolysocardiolipin (1-16:0, 2-16:1, 4-16:1) monolysocardiolipin (1-16:0, 2-16:1, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (1-16:0, 2-16:1, 4-18:1) monolysocardiolipin (1-16:0, 2-16:1, 4-18:1) 0 Wrong charge in mm. +monolysocardiolipin (1-16:0, 2-18:1, 4-16:1) monolysocardiolipin (1-16:0, 2-18:1, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (1-16:0, 2-18:1, 4-18:1) monolysocardiolipin (1-16:0, 2-18:1, 4-18:1) 0 Wrong charge in mm. +monolysocardiolipin (1-16:1, 2-16:1, 4-16:1) monolysocardiolipin (1-16:1, 2-16:1, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (1-16:1, 2-16:1, 4-18:1) monolysocardiolipin (1-16:1, 2-16:1, 4-18:1) 0 Wrong charge in mm. +monolysocardiolipin (1-16:1, 2-18:1, 4-16:1) monolysocardiolipin (1-16:1, 2-18:1, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (1-16:1, 2-18:1, 4-18:1) monolysocardiolipin (1-16:1, 2-18:1, 4-18:1) 0 Wrong charge in mm. +monolysocardiolipin (1-18:0, 2-16:1, 4-16:1) monolysocardiolipin (1-18:0, 2-16:1, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (1-18:0, 2-16:1, 4-18:1) monolysocardiolipin (1-18:0, 2-16:1, 4-18:1) 0 Wrong charge in mm. +monolysocardiolipin (1-18:1, 2-16:1, 4-16:1) monolysocardiolipin (1-18:1, 2-16:1, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (1-18:1, 2-16:1, 4-18:1) monolysocardiolipin (1-18:1, 2-16:1, 4-18:1) 0 Wrong charge in mm. +monolysocardiolipin (2-16:1, 3-16:0, 4-16:1) monolysocardiolipin (2-16:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (2-16:1, 3-16:0, 4-18:1) monolysocardiolipin (2-16:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. +monolysocardiolipin (2-16:1, 3-16:1, 4-16:1) monolysocardiolipin (2-16:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (2-16:1, 3-16:1, 4-18:1) monolysocardiolipin (2-16:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. +monolysocardiolipin (2-16:1, 3-18:0, 4-16:1) monolysocardiolipin (2-16:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (2-16:1, 3-18:1, 4-16:1) monolysocardiolipin (2-16:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (2-18:1, 3-16:0, 4-16:1) monolysocardiolipin (2-18:1, 3-16:0, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (2-18:1, 3-16:0, 4-18:1) monolysocardiolipin (2-18:1, 3-16:0, 4-18:1) 0 Wrong charge in mm. +monolysocardiolipin (2-18:1, 3-16:1, 4-16:1) monolysocardiolipin (2-18:1, 3-16:1, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (2-18:1, 3-16:1, 4-18:1) monolysocardiolipin (2-18:1, 3-16:1, 4-18:1) 0 Wrong charge in mm. +monolysocardiolipin (2-18:1, 3-18:0, 4-16:1) monolysocardiolipin (2-18:1, 3-18:0, 4-16:1) 0 Wrong charge in mm. +monolysocardiolipin (2-18:1, 3-18:1, 4-16:1) monolysocardiolipin (2-18:1, 3-18:1, 4-16:1) 0 Wrong charge in mm. +myo-inositol myo-inositol CHEBI:17268 C00137 0 Wrong CHEBI in erm. Wrong KEGG in erm. +myristate myristate CHEBI:30807 C06424 -1 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. +myristoyl-CoA myristoyl-CoA CHEBI:57385 C02593 -4 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. +NAD NAD CHEBI:57540 C00003 -1 Wrong CHEBI in erm. Wrong KEGG in erm. +NADH NADH CHEBI:57945 C00004 -2 Wrong CHEBI in erm. Wrong KEGG in erm. +NADP(+) NADP(+) CHEBI:58349 C00006 -3 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. +NADPH NADPH CHEBI:57783 C00005 -4 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. +oleate oleate CHEBI:30823 C00712 -1 Wrong CHEBI in e/erm/lp/p/ce/m. Wrong KEGG in e/erm/lp/p/ce/m. +oleoyl-CoA oleoyl-CoA CHEBI:57387 C00510 -4 Wrong CHEBI in erm/lp/mm. Wrong KEGG in erm/lp/mm. +oxygen oxygen CHEBI:15379 C00007 0 Wrong CHEBI in erm. Wrong KEGG in erm. +palmitate palmitate CHEBI:7896 C00249 -1 Wrong CHEBI in erm/lp/mm/ce. Wrong KEGG in erm/lp/mm/ce. +palmitoleate palmitoleate CHEBI:32372 C08362 -1 Wrong CHEBI in erm/lp/ce. Wrong KEGG in erm/lp/ce. +palmitoleoyl-CoA palmitoleoyl-CoA(4-) CHEBI:61540 C21072 -4 wrong chebiID and keggid. update fullname, keggid and full name in chebi +palmitoyl-CoA palmitoyl-CoA CHEBI:57379 C00154 -4 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. +Phe-tRNA(Phe) Phe-tRNA(Phe) CHEBI:29153 C03511 0 Wrong charge in c/m. +phosphate phosphate CHEBI:43474 C00009 -2 Wrong CHEBI in erm/vm/gm/mm/ce. Wrong KEGG in erm/vm/gm/mm/ce. +phosphatidate (1-16:0, 2-16:1) phosphatidate (1-16:0, 2-16:1) CHEBI:73998 -2 new chebiID. Update charge. chebi has some problemthis is a charged chebi id 2- +phosphatidate (1-16:0, 2-18:1) phosphatidate (1-16:0, 2-18:1) CHEBI:64844 C13889 0 new chebiID. new keggid +phosphatidate (1-16:1, 2-16:1) phosphatidate (1-16:1, 2-16:1) CHEBI:75071 0 new chebiID +phosphatidate (1-16:1, 2-18:1) phosphatidate (1-16:1, 2-18:1) 0 "new chebiID. standard fullname: 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphate Synonyms: PA(18:1(9Z)/16:1(9Z));remove duplicated chebiID" +phosphatidate (1-18:0, 2-16:1) phosphatidate (1-18:0, 2-16:1) CHEBI:75073 0 new chebiID +phosphatidate (1-18:0, 2-18:1) phosphatidate (1-18:0, 2-18:1) CHEBI:74847 0 new chebiID +phosphatidate (1-18:1, 2-16:1) phosphatidate (1-18:1, 2-16:1) CHEBI:75074 0 new chebiID +phosphatidate (1-18:1, 2-18:1) phosphatidate (1-18:1, 2-18:1) CHEBI:83775 0 new chebiID +phosphatidylcholine (1-16:0, 2-16:1) phosphatidylcholine (1-16:0, 2-16:1) CHEBI:134592 0 new chebiID +phosphatidylcholine (1-16:0, 2-18:1) phosphatidylcholine (1-16:0, 2-18:1) CHEBI:134594 0 new chebiID +phosphatidylcholine (1-16:1, 2-16:1) phosphatidylcholine (1-16:1, 2-16:1) CHEBI:134637 0 new chebiID +phosphatidylcholine (1-16:1, 2-18:1) phosphatidylcholine (1-16:1, 2-18:1) CHEBI:89668 0 new chebiID +phosphatidylcholine (1-18:0, 2-16:1) phosphatidylcholine (1-18:0, 2-16:1) CHEBI:89972 0 new chebiID +phosphatidylcholine (1-18:0, 2-18:1) phosphatidylcholine (1-18:0, 2-18:1) CHEBI:89679 0 new chebiID +phosphatidylcholine (1-18:1, 2-16:1) phosphatidylcholine (1-18:1, 2-16:1) CHEBI:89506 0 new chebiID +phosphatidylcholine (1-18:1, 2-18:1) phosphatidylcholine (1-18:1, 2-18:1) CHEBI:89504 0 new chebiID +phosphatidylethanolamine (1-16:0, 2-16:1) phosphatidylethanolamine (1-16:0, 2-16:1) CHEBI:136147 0 new chebiID +phosphatidylethanolamine (1-16:0, 2-18:1) phosphatidylethanolamine (1-16:0, 2-18:1) CHEBI:136148 0 new chebiID +phosphatidylethanolamine (1-16:1, 2-16:1) phosphatidylethanolamine (1-16:1, 2-16:1) CHEBI:138792 0 new chebiID +phosphatidylethanolamine (1-16:1, 2-18:1) phosphatidylethanolamine (1-16:1, 2-18:1) CHEBI:90464 0 new chebiID +phosphatidylethanolamine (1-18:0, 2-16:1) phosphatidylethanolamine (1-18:0, 2-16:1) CHEBI:136155 0 new chebiID. CHEBI:136155 for phosphatidylethanolamine (16:1/18:0). has charge of 0 +phosphatidylethanolamine (1-18:0, 2-18:1) phosphatidylethanolamine (1-18:0, 2-18:1) CHEBI:136162 0 new chebiID +phosphatidylethanolamine (1-18:1, 2-16:1) phosphatidylethanolamine (1-18:1, 2-16:1) CHEBI:82837 0 new chebiID +phosphatidylethanolamine (1-18:1, 2-18:1) phosphatidylethanolamine (1-18:1, 2-18:1) CHEBI:136170 0 new chebiID +phosphatidylglycerol (1-16:0, 2-16:1) phosphatidylglycerol (1-16:0, 2-16:1) CHEBI:136224 0 new chebiID. CHEBI:17517 for phosphatidylglycerol. has charge of -1 +phosphatidylglycerol (1-16:0, 2-18:1) phosphatidylglycerol (1-16:0, 2-18:1) CHEBI:34080 C13833 0 new keggid +phosphatidylglycerol (1-16:1, 2-16:1) phosphatidylglycerol (1-16:1, 2-16:1) 0 Wrong charge in mm. +phosphatidylglycerol (1-16:1, 2-18:1) phosphatidylglycerol (1-16:1, 2-18:1) CHEBI:89398 0 new chebiID +phosphatidylglycerol (1-18:0, 2-16:1) phosphatidylglycerol (1-18:0, 2-16:1) CHEBI:89270 0 new chebiID +phosphatidylglycerol (1-18:1, 2-16:1) phosphatidylglycerol (1-18:1, 2-16:1) CHEBI:89093 0 new chebiID +phosphatidyl-L-serine (1-16:0, 2-16:1) phosphatidyl-L-serine (1-16:0, 2-16:1) CHEBI:89824 0 new chebiID. CHEBI:18303 for phosphatidyl-L-serine +phosphatidyl-L-serine (1-16:0, 2-18:1) phosphatidyl-L-serine (1-16:0, 2-18:1) CHEBI:134541 0 new chebiID +phosphatidyl-L-serine (1-16:1, 2-16:1) phosphatidyl-L-serine (1-16:1, 2-16:1) 0 Wrong charge in erm/mm/gm/vm/ce. +phosphatidyl-L-serine (1-16:1, 2-18:1) phosphatidyl-L-serine (1-16:1, 2-18:1) CHEBI:90032 0 new chebiID +phosphatidyl-L-serine (1-18:0, 2-16:1) phosphatidyl-L-serine (1-18:0, 2-16:1) CHEBI:90036 0 new chebiID +phosphatidyl-L-serine (1-18:0, 2-18:1) phosphatidyl-L-serine (1-18:0, 2-18:1) CHEBI:90433 0 new chebiID +phosphatidyl-L-serine (1-18:1, 2-16:1) phosphatidyl-L-serine (1-18:1, 2-16:1) CHEBI:75101 0 new chebiID +phosphatidyl-L-serine (1-18:1, 2-18:1) phosphatidyl-L-serine (1-18:1, 2-18:1) CHEBI:60568 0 new chebiID +phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-16:1) phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-16:1) 0 Wrong charge in erm. +phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-18:1) phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-18:1) 0 Wrong charge in erm. +phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-16:1) phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-16:1) 0 Wrong charge in erm. +phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-18:1) phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-18:1) 0 Wrong charge in erm. +phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-16:1) phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-16:1) 0 Wrong charge in erm. +phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-18:1) phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-18:1) 0 Wrong charge in erm. +phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-16:1) phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-16:1) 0 Wrong charge in erm. +phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-18:1) phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-18:1) CHEBI:85963 0 new chebiID. CHEBI:85963 for 1.2-dioleoyl-sn-glycero-3-phospho-N.N-dimethylethanolamine. PE-NMe2(18:1/18:1) has charge of 0 +phosphatidyl-N-methylethanolamine (1-16:0, 2-16:1) phosphatidyl-N-methylethanolamine (1-16:0, 2-16:1) 0 Wrong charge in erm. +phosphatidyl-N-methylethanolamine (1-16:0, 2-18:1) phosphatidyl-N-methylethanolamine (1-16:0, 2-18:1) 0 Wrong charge in erm. +phosphatidyl-N-methylethanolamine (1-16:1, 2-16:1) phosphatidyl-N-methylethanolamine (1-16:1, 2-16:1) 0 Wrong charge in erm. +phosphatidyl-N-methylethanolamine (1-16:1, 2-18:1) phosphatidyl-N-methylethanolamine (1-16:1, 2-18:1) 0 Wrong charge in erm. +phosphatidyl-N-methylethanolamine (1-18:0, 2-16:1) phosphatidyl-N-methylethanolamine (1-18:0, 2-16:1) 0 Wrong charge in erm. +phosphatidyl-N-methylethanolamine (1-18:0, 2-18:1) phosphatidyl-N-methylethanolamine (1-18:0, 2-18:1) 0 Wrong charge in erm. +phosphatidyl-N-methylethanolamine (1-18:1, 2-16:1) phosphatidyl-N-methylethanolamine (1-18:1, 2-16:1) 0 Wrong charge in erm. +phosphatidyl-N-methylethanolamine (1-18:1, 2-18:1) phosphatidyl-N-methylethanolamine (1-18:1, 2-18:1) CHEBI:85962 0 new chebiID. CHEBI:85962 for 1.2-dioleoyl-sn-glycero-3-phospho-N-methylethanolamine. PE-NMe(18:1/18:1) has charge of 0 +prenyl diphosphate prenyl diphosphate(3-) CHEBI:57623 C00235 -3 update fullname +Pro-tRNA(Pro) Pro-tRNA(Pro) CHEBI:29154 C02702 0 Wrong charge in c. +raffinose raffinose CHEBI:16634 C00492 0 new chebiID. New keggid +S(8)-aminomethyldihydrolipoylprotein S(8)-aminomethyldihydrolipoylprotein CHEBI:16882 C01242 0 Wrong charge in m. +S-adenosyl-L-homocysteine S-adenosyl-L-homocysteine CHEBI:16680 C00021 0 Wrong CHEBI in erm. Wrong KEGG in erm. +S-adenosyl-L-methionine S-adenosyl-L-methionine CHEBI:15414 C00019 1 Wrong CHEBI in erm. Wrong KEGG in erm. +Ser-tRNA(Ser) Ser-tRNA(Ser) CHEBI:29162 C02553 0 Wrong charge in c. +sn-2-acyl-1-lysophosphatidylinositol (16:1) sn-2-acyl-1-lysophosphatidylinositol (16:1) 0 Wrong charge in erm. +sn-2-acyl-1-lysophosphatidylinositol (18:1) sn-2-acyl-1-lysophosphatidylinositol (18:1) 0 Wrong charge in erm. +sn-glycero-3-phosphocholine sn-glycero-3-phosphocholine CHEBI:16870 C00670 0 Update charge. Wrong standard formula and charge according to the chebiID +sn-glycero-3-phosphoethanolamine sn-glycero-3-phosphoethanolamine CHEBI:16929 C01233 0 new chebiID. New keggid +sn-glycero-3-phosphoserine sn-glycero-3-phosphoserine CHEBI:64945 0 new chebiID. has charge of -1 +stearate stearate CHEBI:25629 C01530 -1 Wrong CHEBI in erm/lp/mm/ce. Wrong KEGG in erm/lp/mm/ce. +stearoyl-CoA stearoyl-CoA CHEBI:57394 C00412 -4 Wrong CHEBI in erm/lp. Wrong KEGG in erm/lp. +tetracosanoyl-CoA tetracosanoyl-CoA CHEBI:52974 C16529 0 Wrong CHEBI in erm/ce/lp. Wrong KEGG in erm/ce/lp. +Thr-tRNA(Thr) Thr-tRNA(Thr) CHEBI:29163 C02992 0 Wrong charge in c/m. +trans-2,cis-5-dodecadienoyl-CoA trans-2,cis-5-dodecadienoyl-CoA 0 wrong chebiID and keggid. Can't find chebiID according to the fullname +trans-2,cis-5-tetradecadienoyl-CoA trans-2,cis-5-tetradecadienoyl-CoA 0 "wrong chebiID and keggid. CHEBI:72001 for (3E.5Z)-tetradecadienoyl-CoA. Has charge of -4;remove duplicated chebiID" +trans-2,cis-7-hexadecadienoyl-CoA trans-2,cis-7-hexadecadienoyl-CoA CHEBI:88086 0 wrong chebiID and keggid. CHEBI:88086 for (2E.7Z)-hexadecadienoyl-CoA. Has charge of -4 +trans-2,cis-7-tetradecadienoyl-CoA trans-2,cis-7-tetradecadienoyl-CoA CHEBI:88067 0 wrong chebiID and keggid. CHEBI:88067 for (2E.5Z)-tetradecadienoyl-CoA +trans-2,cis-9-hexadecadienoyl-CoA trans-2,cis-9-hexadecadienoyl-CoA CHEBI:76889 0 wrong chebiID and keggid. CHEBI:76889 for (9Z.12Z)-hexadecadienoyl-CoA?? Has charge of -4 +trans-2,cis-9-octadecadienoyl-CoA trans-2,cis-9-octadecadienoyl-CoA CHEBI:15530 C02050 0 wrong chebiID and wrong keggid. CHEBI:15530 for (9Z.12Z)-Octadecadienoyl-CoA linoleoyl-CoA is the standard fullname +trans-2,trans-4-dodecadienoyl-CoA trans-2,trans-4-dodecadienoyl-CoA CHEBI:28002 C05280 0 new chebiID. new keggid. CHEBI:28002 for (3Z.6Z)-dodecadienoyl-CoA has charge of 0 +trans-2,trans-4-tetradecadienoyl-CoA trans-2,trans-4-tetradecadienoyl-CoA CHEBI:88084 0 new chebiID +trans-3,cis-5-dodecadienoyl-CoA trans-3,cis-5-dodecadienoyl-CoA CHEBI:139121 0 new chebiID. Has charge of -4 +trans-3,cis-5-tetradecadienoyl-CoA trans-3,cis-5-tetradecadienoyl-CoA CHEBI:72001 0 new chebiID +trans-but-2-enoyl-ACP trans-but-2-enoyl-ACP CHEBI:132146 0 wrong chebiID and keggid +trans-but-2-enoyl-CoA but-2-enoyl-CoA CHEBI:36926 C00877 0 new keggid, formula & fullname. Wrong chebiID. +trans-docos-2-enoyl-CoA trans-docos-2-enoyl-CoA 0 "Wrong chebiID and keggid. Not standard fullname;remove duplicated chebiID;remove duplicated keggID" +trans-dodec-3-enoyl-CoA trans-dodec-3-enoyl-CoA 0 "new chebiID. new keggid. CHEBI:15471 for trans-dodec-2-enoyl-CoA has charge of 0.;remove duplicated chebiID;remove duplicated keggID" +trans-hex-2-enoyl-ACP trans-hex-2-enoyl-ACP CHEBI:10727 C05748 0 wrong chebiID and keggid +trans-hex-2-enoyl-CoA trans-hex-2-enoyl-CoA CHEBI:28706 C05271 0 wrong chebiID and keggid. update keggid, formula. has formula in charge of -4. +trans-hexacos-2-enoyl-CoA trans-hexacos-2-enoyl-CoA CHEBI:52975 0 Wrong CHEBI in erm. Wrong KEGG in erm. +trans-hexadec-2-enoyl-CoA trans-hexadec-2-enoyl-CoA C05272 0 "Wrong chebiID and keggid;remove duplicated chebiID" +trans-icos-2-enoyl-CoA trans-icos-2-enoyl-CoA 0 Wrong chebiID and keggid. Can't find such a metabolite in chebi +trans-oct-2-enoyl-ACP trans-oct-2-enoyl-ACP C05751 0 wrong chebiID. can't find such a metabolite in chebi. Not standard fullname +trans-oct-2-enoyl-CoA trans-oct-2-enoyl-CoA CHEBI:27537 C05276 0 wrong chebiID and keggid. update keggid, formula. has formula in charge of -4. +trans-octadec-2-enoyl-CoA trans-octadec-2-enoyl-CoA CHEBI:50570 C16218 0 Wrong CHEBI in erm. Wrong KEGG in erm. +trans-tetracos-2-enoyl-CoA trans-tetracos-2-enoyl-CoA CHEBI:75068 0 Wrong chebiID and keggid. Not standard fullname. should be trans-2-tetracosenoyl-CoA has charge of -4 according to YMDB +trans-tetradec-2-enoyl-CoA trans-tetradec-2-enoyl-CoA CHEBI:61405 C05273 -4 Wrong CHEBI in erm. Wrong KEGG in erm. +trans-tetradec-3-enoyl-CoA trans-tetradec-3-enoyl-CoA CHEBI:88083 0 new chebiID. CHEBI:88083 for (3E)-tetradecenoyl-CoA trans-3-tetradecenoyl-CoA has charge of 0 +triglyceride (1-16:0, 2-16:1, 3-16:0) triglyceride (1-16:0, 2-16:1, 3-16:0) CHEBI:85427 0 new chebiID. chebi has some problem. this is 16:0.16:0.16:1 +triglyceride (1-16:0, 2-16:1, 3-16:1) triglyceride (1-16:0, 2-16:1, 3-16:1) CHEBI:89765 0 new chebiID +triglyceride (1-16:0, 2-16:1, 3-18:0) triglyceride (1-16:0, 2-16:1, 3-18:0) CHEBI:89763 0 new chebiID +triglyceride (1-16:0, 2-16:1, 3-18:1) triglyceride (1-16:0, 2-16:1, 3-18:1) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" +triglyceride (1-16:0, 2-18:1, 3-16:0) triglyceride (1-16:0, 2-18:1, 3-16:0) CHEBI:89759 0 new chebiID +triglyceride (1-16:0, 2-18:1, 3-16:1) triglyceride (1-16:0, 2-18:1, 3-16:1) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" +triglyceride (1-16:0, 2-18:1, 3-18:0) triglyceride (1-16:0, 2-18:1, 3-18:0) CHEBI:88998 0 new chebiID +triglyceride (1-16:0, 2-18:1, 3-18:1) triglyceride (1-16:0, 2-18:1, 3-18:1) 0 "new chebiID;remove duplicated chebiID" +triglyceride (1-16:1, 2-16:1, 3-16:0) triglyceride (1-16:1, 2-16:1, 3-16:0) 0 "new chebiID;remove duplicated chebiID" +triglyceride (1-16:1, 2-16:1, 3-16:1) triglyceride (1-16:1, 2-16:1, 3-16:1) CHEBI:75841 0 new chebiID +triglyceride (1-16:1, 2-16:1, 3-18:0) triglyceride (1-16:1, 2-16:1, 3-18:0) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" +triglyceride (1-16:1, 2-16:1, 3-18:1) triglyceride (1-16:1, 2-16:1, 3-18:1) CHEBI:90051 0 new chebiID +triglyceride (1-16:1, 2-18:1, 3-16:0) triglyceride (1-16:1, 2-18:1, 3-16:0) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" +triglyceride (1-16:1, 2-18:1, 3-16:1) triglyceride (1-16:1, 2-18:1, 3-16:1) 0 "new chebiID;remove duplicated chebiID" +triglyceride (1-16:1, 2-18:1, 3-18:0) triglyceride (1-16:1, 2-18:1, 3-18:0) 0 "new chebiID;remove duplicated chebiID" +triglyceride (1-16:1, 2-18:1, 3-18:1) triglyceride (1-16:1, 2-18:1, 3-18:1) CHEBI:90048 0 new chebiID +triglyceride (1-18:0, 2-16:1, 3-16:0) triglyceride (1-18:0, 2-16:1, 3-16:0) 0 "new chebiID;remove duplicated chebiID" +triglyceride (1-18:0, 2-16:1, 3-16:1) triglyceride (1-18:0, 2-16:1, 3-16:1) CHEBI:90053 0 new chebiID +triglyceride (1-18:0, 2-16:1, 3-18:0) triglyceride (1-18:0, 2-16:1, 3-18:0) CHEBI:89958 0 new chebiID +triglyceride (1-18:0, 2-16:1, 3-18:1) triglyceride (1-18:0, 2-16:1, 3-18:1) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" +triglyceride (1-18:0, 2-18:1, 3-16:0) triglyceride (1-18:0, 2-18:1, 3-16:0) CHEBI:89755 0 new chebiID +triglyceride (1-18:0, 2-18:1, 3-16:1) triglyceride (1-18:0, 2-18:1, 3-16:1) 0 "new chebiID;remove duplicated chebiID" +triglyceride (1-18:0, 2-18:1, 3-18:0) triglyceride (1-18:0, 2-18:1, 3-18:0) CHEBI:90305 0 new chebiID. CHEBI:90305 for triacylglycerol 54:1 . has charge of 0 +triglyceride (1-18:0, 2-18:1, 3-18:1) triglyceride (1-18:0, 2-18:1, 3-18:1) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" +triglyceride (1-18:1, 2-16:1, 3-16:0) triglyceride (1-18:1, 2-16:1, 3-16:0) 0 "new chebiID;remove duplicated chebiID" +triglyceride (1-18:1, 2-16:1, 3-16:1) triglyceride (1-18:1, 2-16:1, 3-16:1) 0 "new chebiID;remove duplicated chebiID" +triglyceride (1-18:1, 2-16:1, 3-18:0) triglyceride (1-18:1, 2-16:1, 3-18:0) 0 "new chebiID;remove duplicated chebiID" +triglyceride (1-18:1, 2-16:1, 3-18:1) triglyceride (1-18:1, 2-16:1, 3-18:1) CHEBI:88984 0 new chebiID +triglyceride (1-18:1, 2-18:1, 3-16:0) triglyceride (1-18:1, 2-18:1, 3-16:0) CHEBI:88999 0 new chebiID. chebi has some problem. this is 11z +triglyceride (1-18:1, 2-18:1, 3-16:1) triglyceride (1-18:1, 2-18:1, 3-16:1) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" +triglyceride (1-18:1, 2-18:1, 3-18:0) triglyceride (1-18:1, 2-18:1, 3-18:0) 0 "new chebiID. chebi has some problem. this is 11z;remove duplicated chebiID" +triglyceride (1-18:1, 2-18:1, 3-18:1) triglyceride (1-18:1, 2-18:1, 3-18:1) CHEBI:88970 0 new chebiID. chebi has some problem. this is 11z +tRNA(Arg) tRNA(Arg) CHEBI:29171 C01636 0 New keggid +tRNA(Asn) tRNA(Asn) CHEBI:29172 C01637 0 New keggid +tRNA(Asp) tRNA(Asp) CHEBI:29186 C01638 0 New keggid +tRNA(Glu) tRNA(Glu) CHEBI:29175 C01641 0 New keggid +tRNA(His) tRNA(His) CHEBI:29178 C01643 0 New keggid +tRNA(Ile) tRNA(Ile) CHEBI:29174 C01644 0 New keggid +tRNA(Leu) tRNA(Leu) CHEBI:29169 C01645 0 New keggid +tRNA(Lys) tRNA(Lys) CHEBI:29185 C01646 0 New keggid +tRNA(Met) tRNA(Met) CHEBI:29173 C01647 0 New keggid +tRNA(Phe) tRNA(Phe) CHEBI:29184 C01648 0 New keggid +tRNA(Thr) tRNA(Thr) CHEBI:29180 C01651 0 New keggid +tRNA(Trp) tRNA(Trp) CHEBI:29181 C01652 0 New keggid +tRNA(Tyr) tRNA(Tyr) CHEBI:29182 C00787 0 New keggid +tRNA(Val) tRNA(Val) CHEBI:29183 C01653 0 New keggid +Trp-tRNA(Trp) Trp-tRNA(Trp) CHEBI:29159 C03512 0 Wrong charge in c/m. +TRX1 TRX1 CHEBI:15967 C00342 0 Wrong charge in c/m/n/p. +TRX1 disulphide TRX1 disulphide CHEBI:18191 C00343 0 Wrong charge in c/m/n/p. +TTP thiamine(1+) triphosphate(4-) CHEBI:58938 C03028 -3 update fullname +Tyr-tRNA(Tyr) Tyr-tRNA(Tyr) CHEBI:29161 C02839 0 Wrong charge in c/m. +Val-tRNA(Val) Val-tRNA(Val) CHEBI:29164 C02554 0 Wrong charge in c/m. +zymosterol zymosterol CHEBI:18252 C05437 0 Wrong CHEBI in erm. Wrong KEGG in erm. +zymosteryl oleate zymosteryl oleate CHEBI:52384 0 new chebiID +zymosteryl palmitoleate zymosteryl palmitoleate CHEBI:52385 0 new chebiID +trans-dec-2-enoyl-CoA trans-dec-2-enoyl-CoA C05275 -4 remove duplicated chebiID +trans-dodec-2-enoyl-CoA trans-dodec-2-enoyl-CoA C03221 -4 remove duplicated chebiID hexadec-2-enoyl-CoA hexadec-2-enoyl-CoA 0 "remove duplicated chebiID;remove duplicated keggID" \ No newline at end of file diff --git a/ComplementaryData/modelCuration/modMetsandSmatrix.tsv b/ComplementaryData/modelCuration/modMetsandSmatrix.tsv new file mode 100644 index 00000000..5066e3b8 --- /dev/null +++ b/ComplementaryData/modelCuration/modMetsandSmatrix.tsv @@ -0,0 +1,843 @@ +% +#for correction of metFormula (and metCharges) to balance equation "#Note: no changes are made to R groups in model.metFormulas, since R groups can represent any CnHn and modification may cause other reactions to have unbalanced R groups" +#model.mets model.metFormulas new_metFormulas model.metCharges new_metCharges refMNXMID rxn/related rxn(s) refMNXRID elementdiff Notes MNXNotes KEGGNotes ChEBINotes otherDatabaseNotes +s_0710[m] C42H44FeN8O8S2R4 C42H45FeN8O8S2R4 0 [] MNXM746 r_0001 MNXR138960 H2 s_0710[m]: changed metFormula C42H44FeN8O8S2R4 to C42H45FeN8O8S2R4 to balance equation "| ferricytochrome c is reduced to form ferrocytochrome c, thus 2 H added to metFormula for ferrocytochrome" [] [] [] +s_0142[c] C9H18N5O8P C9H16N5O8P 0 -2 MNXM1099 r_0014 MNXR112805 H2 s_0142[c]: changed metFormula C9H18N5O8P to C9H16N5O8P to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM1099 [] [] [] +s_0194[c] C10H12N5O5P C10H11N5O5P 0 -1 MNXM9931 r_0034 MNXR136084 H1 s_0194[c]: changed metFormula C10H12N5O5P to C10H11N5O5P to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM9931 [] [] [] +s_0196[c] C10H11N4O7P C10H10N4O7P 0 -1 MNXM9932 r_0035 MNXR136083 H1 s_0196[c]: changed metFormula C10H11N4O7P to C10H10N4O7P to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM9932 [] [] [] +s_0158[c] C4H9O6P C4H7O6P 0 -2 MNXM2323 r_0038 MNXR97178 H-2 s_0158[c]: changed metFormula C4H9O6P to C4H7O6P to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM2323 [] [] [] +s_0215[c] C37H54O3 C37H53O3 0 -1 MNXM3167 r_0043 MNXR110601 H1 s_0215[c]: changed metFormula C37H54O3 to C37H53O3 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM3167 [] | based on metFormula in CHEBI:31116 +s_0054[p] C35H62N7O18P3S C35H58N7O18P3S 0 -4 MNXM767 r_0057 MNXR100547 H4 s_0054[p]: changed metFormula C35H62N7O18P3S to C35H58N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM767 [] [] [] +s_0147[c] C7H5NO5 C7H6NO5 -2 -1 MNXM1372 r_0058 MNXR94889 H1 s_0147[c]: changed metFormula C7H5NO5 to C7H6NO5 to balance equation | changed metCharges -2 to -1 to balance equation | based on metFormula in MNXM1372 [] [] [] +s_1488[m] C19H23N7O6 C19H21N7O6 0 -2 MNXM79 r_0063; r_0503 MNXR100142 H2 s_1488[m]: changed metFormula C19H23N7O6 to C19H21N7O6 to balance equation | changed metCharges 0 to -2 to balance equation [] [] [] [] +s_0269[c] C10H9NO5 C10H10NO5 -2 -1 MNXM1458 r_0066; r_0067 MNXR95440 H1 s_0269[c]: changed metFormula C10H9NO5 to C10H10NO5 to balance equation | changed metCharges -2 to -1 to balance equation | based on metFormula in MNXM1458 [] [] [] +s_0279[c] C6H19O27P7 C6H6O27P7 0 -13 MNXM37435 r_0073 MNXR103044 H12 s_0279[c]: changed metFormula C6H19O27P7 to C6H6O27P7 to balance equation | changed metCharges 0 to -13 to balance equation [] [] [] [] +s_0263[c] C6H20O30P8 C6H7O30P8 0 -13 MNXM484827 r_0074 [] O-1H-14 s_0263[c]: changed metFormula C6H20O30P8 to C6H7O30P8 to balance equation | changed metCharges 0 to -13 to balance equation [] [] [] [] +s_0333[c] C6H19O27P7 C6H6O27P7 0 -13 MNXM38670 r_0092; r_0093 MNXR103044 H12 s_0333[c]: changed metFormula C6H19O27P7 to C6H6O27P7 to balance equation | changed metCharges 0 to -13 to balance equation [] [] [] [] +s_0309[c] C6H20O30P8 C6H7O30P8 0 -13 MNXM487477 r_0093 [] O-1H-14 s_0309[c]: changed metFormula C6H20O30P8 to C6H7O30P8 to balance equation | changed metCharges 0 to -13 to balance equation [] [] [] [] +s_0250[p] C39H68N7O18P3S C39H64N7O18P3S 0 -4 MNXM513 r_0100 MNXR95204 H4 s_0250[p]: changed metFormula C39H68N7O18P3S to C39H64N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM513 [] [] [] +s_0243[p] C47H84N7O18P3S C47H80N7O18P3S 0 -4 MNXM36758 r_0101; r_2160 MNXR124343 H4 s_0243[p]: changed metFormula C47H84N7O18P3S to C47H80N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_0257[p] C35H60N7O18P3S C35H56N7O18P3S 0 -4 MNXM707 r_0105 MNXR95201 H4 s_0257[p]: changed metFormula C35H60N7O18P3S to C35H56N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM707 [] [] [] +s_0239[p] C31H52N7O18P3S C31H48N7O18P3S 0 -4 MNXM677 r_0106 MNXR95198 H4 s_0239[p]: changed metFormula C31H52N7O18P3S to C31H48N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM677 [] [] [] +s_0247[p] C33H56N7O18P3S C33H52N7O18P3S 0 -4 MNXM705 r_0107 MNXR95200 H4 s_0247[p]: changed metFormula C33H56N7O18P3S to C33H52N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM705 [] [] [] +s_1513[p] C47H84N7O17P3S C47H80N7O17P3S 0 -4 MNXM114303 r_0122; r_2181 (s_2815[erm]) MNXR124346 H-4 s_1513[p]: changed metFormula C47H84N7O17P3S to C47H80N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_0823[p] C37H64N7O17P3S C37H60N7O17P3S 0 -4 MNXM581 r_0123 MNXR95367 H-4 s_0823[p]: changed metFormula C37H64N7O17P3S to C37H60N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM581 [] [] [] +s_1516[p] C39H68N7O17P3S C39H64N7O17P3S 0 -4 MNXM954 r_0124 MNXR95368 H-4 s_1516[p]: changed metFormula C39H68N7O17P3S to C39H64N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM954 [] [] [] +s_0341[c] C9H19N2O2 C9H21N2O2 -1 1 MNXM1140 r_0146 MNXR95806 H2 s_0341[c]: changed metFormula C9H19N2O2 to C9H21N2O2 to balance equation | changed metCharges -1 to 1 to balance equation | based on metFormula in MNXM1140 [] [] [] +s_0389[c] C10H14N5O7P C10H12N5O7P 0 -2 MNXM7028 r_0155 MNXR117324 H-2 s_0389[c]: changed metFormula C10H14N5O7P to C10H12N5O7P to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM7028 [] [] [] +s_0404[c] C3H6NOR C3H7NOR 0 1 MNXM89576 r_0157 MNXR107903 [] s_0404[c]: changed metFormula C3H6NOR to C3H7NOR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID ALANINE--TRNA-LIGASE-RXN +s_1582[c] R RH [] 0 MNXM89576 r_0157 MNXR107903 [] s_1582[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID ALANINE--TRNA-LIGASE-RXN +s_1555[c] C3H6N2O4 C3H5N2O4 0 -1 MNXM490 r_0189 MNXR95767 H-1 s_1555[c]: changed metFormula C3H6N2O4 to C3H5N2O4 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM490 [] [] [] +s_0414[g] C38H68N2O27P2 C48H84N2O27P2 0 [] MNXM41231 r_0192 MNXR109280 H2 s_0414[g]: changed C38H68N2O27P2 to C48H84N2O27P2 to balance equation | based on metFormula in MNXM41231 [] [] [] +s_0444[g] C32H58N2O22P2 C42H72N2O22P2 0 -2 MNXM1078 r_0192 MNXR109280 H2 s_0444[g]: changed metFormula C32H58N2O22P2 to C42H72N2O22P2 to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM1078 [] [] [] +s_0428[c] C6H14N4OR C6H15N4OR 0 2 MNXM89870 r_0209; r_0210 MNXR95950 [] s_0428[c]: changed metFormula C6H14N4OR to C6H15N4OR to balance equation | changed metCharges 0 to 2 to balance equation [] [] [] | Reference to BioCycID ARGININE--TRNA-LIGASE-RXN +s_1583[c] R RH 0 [] MNXM90751 r_0209; r_0210 MNXR95950 [] s_1583[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID ARGININE--TRNA-LIGASE-RXN +s_0430[c] C4H7N2O2R C4H8N2O2R 0 1 MNXM89761 r_0212;r_0213 MNXR96064 [] s_0430[c]: changed metFormula C4H7N2O2R to C4H8N2O2R to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID ASPARAGINE--TRNA-LIGASE-RXN +s_1585[c] R RH 0 [] MNXM90665 r_0212;r_0213 MNXR96064 [] s_1585[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID ASPARAGINE--TRNA-LIGASE-RXN +s_0295[c] C4H5NO7P C4H6NO7P -3 -2 MNXM1177 r_0215; r_0219 MNXR96085 H1 s_0295[c]: changed metFormula C4H5NO7P to C4H6NO7P to balance equation | changed metCharges -3 to -2 to balance equation | based on metFormula in MNXM1177 [] [] [] +s_0432[c] C4H5NO3R C4H6NO3R 0 [] MNXM164570 r_0220; r_0221 MNXR96101 [] s_0432[c]: changed C4H5NO3R to C4H6NO3R to balance equation [] [] [] | Reference to BioCycID ASPARTATE--TRNA-LIGASE-RXN +s_1587[c] R RH 0 [] MNXM90752 r_0220; r_0221 MNXR96101 [] s_1587[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID ASPARTATE--TRNA-LIGASE-RXN +s_1284[c] C20H28N10O20P4 C20H24N10O20P4 0 -4 MNXM66180 r_0223 MNXR136085 H-4 s_1284[c]: changed metFormula C20H28N10O20P4 to C20H24N10O20P4 to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM66180 [] [] [] +s_0443[c] C32H58N2O22P2 C42H72N2O22P2 0 -2 MNXM1078 r_0228 MNXR108930 C10H16 s_0443[c]: changed metFormula C32H58N2O22P2 to C42H72N2O22P2 to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM1078 [] [] [] +s_1184[c] C36H64N2O17P2 C36H62N2O17P2 0 -2 MNXM63078 r_0228 MNXR108930 C10H16 s_1184[c]: changed metFormula C36H64N2O17P2 to C36H62N2O17P2 to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM63078 [] [] [] +s_1578[c] C29H46O2 C28H43O3 0 -1 MNXM89471 r_0234; r_0240 [] C1O-1H2 s_1578[c]: changed metFormula C29H46O2 to C28H43O3 to balance equation | changed metCharges 0 to -1 to balance equation | based on BioCyc ID: RXN66-318 and CHEBI:143575 [] [] [] +s_0297[c] C29H46O3 C29H45O3 0 -1 MNXM37762 r_0235 MNXR128630 H1 s_0297[c]: changed metFormula C29H46O3 to C29H45O3 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM37762 [] [] [] +s_1230[c] C52H78O3 C52H77O3 0 -1 MNXM2847 r_0249 MNXR110956 H2 s_1230[c]: changed metFormula C52H78O3 to C52H77O3 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM2847 [] [] [] +s_1231[c] C45H76O7P2 C45H73O7P2 0 -3 MNXM968 r_0249 MNXR110956 H2 s_1231[c]: changed metFormula C45H76O7P2 to C45H73O7P2 to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in MNXM968 [] [] [] +s_0469[c] C14H26N4O11P2 C14H25N4O11P2 0 -1 MNXM283 r_0274 MNXR96686 H-1 s_0469[c]: changed metFormula C14H26N4O11P2 to C14H25N4O11P2 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM283 [] [] [] +s_0817[er] C47H86N7O17P3S C47H82N7O17P3S 0 -4 MNXM1190 r_0264; r_0266 MNXR110315 H4 s_0817[er]: changed metFormula C47H86N7O17P3S to C47H82N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_1480[er] C45H82N7O17P3S C45H78N7O17P3S 0 -4 MNXM1504 r_0265 MNXR126660 H4 s_1480[er]: changed metFormula C45H82N7O17P3S to C45H78N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_1366[er] C18H39NO3 C18H40NO3 0 1 MNXM914 r_0266 MNXR110323 H3 s_1366[er]: changed metFormula C18H39NO3 to C18H40NO3 to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] [] +s_0510[ce] C6H12NO4 C6H11NO4 0 [] MNXM2106 r_0271 MNXR107444 H-1 s_0510[ce]: changed C6H12NO4 to C6H11NO4 to balance equation | based on metFormula in bigg:chitos (linked to MNXM2106 as external resource) [] [] [] +s_1312[lp] C25H44O7P2 C25H41O7P2 0 -3 MNXM2210 r_0282 MNXR100137 H-3 s_1312[lp]: changed metFormula C25H44O7P2 to C25H41O7P2 to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in MNXM2210 [] [] [] +s_0815[lp] C35H60O7P2 C35H57O7P2 0 -3 MNXM1722 r_0284; r_0285 MNXR100621 H-3 s_0815[lp]: changed metFormula C35H60O7P2 to C35H57O7P2 to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in MNXM1722 [] [] [] +s_0830[lp] C30H52O7P2 C30H49O7P2 0 -3 MNXM1067 r_0284 MNXR100621 H-3 s_0830[lp]: changed metFormula C30H52O7P2 to C30H49O7P2 to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in MNXM1067 [] [] [] +s_1259[lp] C40H68O7P2 C40H65O7P2 0 -3 MNXM811 r_0286 MNXR110950 H3 s_1259[lp]: changed metFormula C40H68O7P2 to C40H65O7P2 to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in MNXM811 [] [] [] +s_0606[lp] C50H84O7P2 C50H81O7P2 0 -3 MNXM1721 r_0287 MNXR112246 H-3 s_0606[lp]: changed metFormula C50H84O7P2 to C50H81O7P2 to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in MNXM1721 [] [] [] +s_1549[lp] C55H92O7P2 C55H89O7P2 0 -3 MNXM5043 r_0288 MNXR105052 H-3 "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM5043 [] [] [] +s_0641[lp] C60H100O7P2 C60H97O7P2 0 -3 MNXM11433 r_0289 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM11433 [] [] [] +s_1523[lp] C65H108O7P2 C65H105O7P2 0 -3 MNXM5721 r_0290 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM5721 [] [] [] +s_1483[lp] C70H116O7P2 C70H113O7P2 0 -3 MNXM83846 r_0291 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM83846 [] [] [] +s_1310[lp] C75H124O7P2 C75H121O7P2 0 -3 MNXM73155 r_0292 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM73155 [] [] [] +s_0829[lp] C80H132O7P2 C80H129O7P2 0 -3 MNXM56347 r_0293 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM56347 [] [] [] +s_0814[lp] C85H140O7P2 C85H137O7P2 0 -3 MNXM56121 r_0294 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM56121 [] [] [] +s_1246[lp] C90H148O7P2 C90H145O7P2 0 -3 MNXM65303 r_0295 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM65303 [] [] [] +s_1229[lp] C95H156O7P2 C95H153O7P2 0 -3 MNXM64863 r_0296 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM64863 [] [] [] +s_0845[lp] C100H164O7P2 C100H161O7P2 0 -3 MNXM57076 r_0297 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM57076 [] [] [] +s_0813[lp] C105H172O7P2 C105H169O7P2 0 -3 MNXM56060 r_0298 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM56060 [] [] [] +s_0640[lp] C110H180O7P2 C110H177O7P2 0 -3 MNXM51449 r_0299 [] [] "| deduced based on downstream reactions involved in dolichol and dolichyl phosphate synthesis - assumption that metFormula and metCharges for dolichol (uncharged), dolichyl phosphate (uncharged) and diphosphate (-3) in current version is correct" | Reference to metFormula in MNXM51449 [] [] [] +s_0542[c] C3H6NOSR C3H7NOSR 0 1 MNXM155005 r_0313 MNXR97018 [] s_0542[c]: changed metFormula C3H6NOSR to C3H7NOSR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID CYSTEINE--TRNA-LIGASE-RXN +s_1589[c] R RH [] 0 MNXM162355 r_0313 MNXR97018 [] s_1589[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID CYSTEINE--TRNA-LIGASE-RXN +s_0556[c] C6H13O9P C6H11O9P 0 -2 MNXM1553 r_0322 MNXR99460 H2 s_0556[c]: changed metFormula C6H13O9P to C6H11O9P to balance equation | changed metCharges 0 to -2 to balance equation [] [] [] [] +s_1108[er] C6H12O6 C6H10O5 0 [] MNXM2020 r_0362 MNXR136057 O-1H-3 s_1108[er]: changed C6H12O6 to C6H10O5 to balance equation | based on metFormula in bigg:mannan (linked to MNXM2020 as external resource) [] [] [] +s_1309[e] C6H8O6 C6H7O6 0 [] MNXM107600 r_0365 [] H1 s_1309[e]: changed C6H8O6 to C6H7O6 to balance equation | based on metFormula in MNXM107600 [] [] [] +s_0555[c] C6H14O12P2 C6H10O12P2 0 -4 MNXM500 r_0449 MNXR106670 H4 s_0555[c]: changed metFormula C6H14O12P2 to C6H10O12P2 to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_0987[c] C8H14N2O5 C8H13N2O5 0 -1 MNXM59390 r_0457 MNXR100451 H-1 s_0987[c]: changed metFormula C8H14N2O5 to C8H13N2O5 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM59390 [] [] [] +s_1311[c] C25H44O7P2 C25H41O7P2 0 -3 MNXM2210 r_0461 MNXR100137 H-3 s_1311[c]: changed metFormula C25H44O7P2 to C25H41O7P2 to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in MNXM2210 [] [] [] +s_0773[c] C6H12O6 C6H10O5 0 [] MNXM55375 r_0463; r_0464; r_0511 MNXR100180 O1H2 s_0773[c]: changed C6H12O6 to C6H10O5 to balance equation | based on metFormula in bigg:glycogen (linked to MNXM55375 as external resource) [] [] [] +s_0568[c] C6H13O9P C6H11O9P 0 -2 MNXM160 r_0467 MNXR106678 H2 s_0568[c]: changed metFormula C6H13O9P to C6H11O9P to balance equation | changed metCharges 0 to -2 to balance equation [] [] [] [] +s_0412[c] C6H14NO8P C6H13NO8P 0 -1 MNXM162238 r_0477; r_0760 MNXR95248 H1 s_0412[c]: changed metFormula C6H14NO8P to C6H13NO8P to balance equation | changed metCharges 0 to -1 to balance equation [] [] [] [] +s_0747[c] C5H9N2O2R C5H10N2O2R 0 1 MNXM89810 r_0478 MNXR100257 [] s_0747[c]: changed metFormula C5H9N2O2R to C5H10N2O2R to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID GLUTAMINE--TRNA-LIGASE-RXN +s_1590[c] R RH [] 0 MNXM71 r_0478 MNXR100257 [] s_1590[c]: changed metFormula R to RH to balance equation | changed metCharges [] to 0 to balance equation [] [] [] | Reference to BioCycID GLUTAMINE--TRNA-LIGASE-RXN +s_0748[c] C5H7NO3R C5H8NO3R 0 [] MNXM89752 r_0479; r_0480 MNXR100295 [] s_0748[c]: changed C5H7NO3R to C5H8NO3R to balance equation [] [] [] | Reference to BioCycID GLURS-RXN +s_1591[c] R RH 0 [] MNXM90886 r_0479; r_0480 MNXR100295 [] s_1591[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID GLURS-RXN +s_1487[c] C19H23N7O6 C19H21N7O6 0 -2 MNXM79 r_0502 MNXR100142 H2 s_1487[c]: changed metFormula C19H23N7O6 to C19H21N7O6 to balance equation | changed metCharges 0 to -2 to balance equation [] [] [] [] +s_1409[m] C9H20N2OS2 C9H21N2OS2 0 1 MNXM81220 r_0504 MNXR100065 H1 s_1409[m]: changed metFormula C9H20N2OS2 to C9H21N2OS2 to balance equation | changed metCharges 0 to 1 to balance equation | based on metFormula in MNXM81220 [] [] [] +s_1098[m] C12H18N2O4S2R2 C8H14NOS2R 0 [] MNXM998 r_0506; r_0508 MNXR100067 C4N2O3H6R1 s_1098[m]: changed C12H18N2O4S2R2 to C8H14NOS2R to balance equation | based on metFormula in C02051 [] [] [] +s_1410[m] C9H18NOS2R C9H19N2OS2R 0 [] MNXM81221 r_0506 MNXR100067 C4N2O3H6R1 s_1410[m]: changed C9H18NOS2R to C9H19N2OS2R to balance equation | based on metFormula in C01242 [] [] [] +s_0628[m] C8H15OS2R C8H16NOS2R 0 [] MNXM1663 r_0508 MNXR100069 C-4N-2O-3H-5R-1 s_0628[m]: changed C8H15OS2R to C8H16NOS2R to balance equation | based on metFormula in MNXM1663 [] [] [] +s_0757[c] C2H4NOR C2H5NOR 0 1 MNXM89763 r_0512 MNXR100365 [] s_0757[c]: changed metFormula C2H4NOR to C2H5NOR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID GLYCINE--TRNA-LIGASE-RXN +s_1593[c] R RH [] 0 MNXM90340 r_0512 MNXR100365 [] s_1593[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID GLYCINE--TRNA-LIGASE-RXN +s_0331[er] C19H29NO18PR2 C19H30NO18PR2 -1 0 MNXM999 r_0518 MNXR95257 H-1 s_0331[er]: changed metFormula C19H29NO18PR2 to C19H30NO18PR2 to balance equation | changed metCharges -1 to 0 to balance equation | based on metFormula in C01288 and CHEBI:15935 [] [] [] +s_0812[m] C49H58FeN4O5 C49H56FeN4O5 0 -2 MNXM1278 r_0530 MNXR100595 H1 s_0812[m]: changed metFormula C49H58FeN4O5 to C49H56FeN4O5 to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM1278 [] [] [] +s_0811[m] C49H56FeN4O6 C49H55FeN4O6 0 -3 MNXM53309 r_0530 MNXR100595 H1 s_0811[m]: changed metFormula C49H56FeN4O6 to C49H55FeN4O6 to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in bigg:hemeA (linked to MNXM53309 as external resource) [] [] [] +s_0832[c] C6H8N3OR C6H9N3OR 0 1 MNXM89831 r_0539; r_0540 MNXR100643 [] s_0832[c]: changed metFormula C6H8N3OR to C6H9N3OR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID HISTIDINE--TRNA-LIGASE-RXN +s_1594[c] R RH 0 [] MNXM90878 r_0539; r_0540 MNXR100643 [] s_1594[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID HISTIDINE--TRNA-LIGASE-RXN +s_0831[m] C30H52O7P2 C30H49O7P2 0 -3 MNXM1067 r_0555 MNXR100569 H3 s_0831[m]: changed metFormula C30H52O7P2 to C30H49O7P2 to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in MNXM1067 [] [] [] +s_0218[c] C27H44N7O20P3S C27H39N7O20P3S 0 -5 MNXM36493 r_0558 MNXR107304 H5 s_0218[c]: changed metFormula C27H44N7O20P3S to C27H39N7O20P3S to balance equation | changed metCharges 0 to -5 to balance equation [] [] [] [] +s_0218[c] C27H44N7O20P3S C27H39N7O20P3S 0 -5 MNXM36493 r_0559; r_1840 MNXR107257 H-5 s_0218[c]: changed metFormula C27H44N7O20P3S to C27H39N7O20P3S to balance equation | changed metCharges 0 to -5 to balance equation [] [] [] [] +s_0221[m] C27H44N7O20P3S C27H39N7O20P3S 0 -5 MNXM36493 r_0560 MNXR107257 H-5 s_0221[m]: changed metFormula C27H44N7O20P3S to C27H39N7O20P3S to balance equation | changed metCharges 0 to -5 to balance equation [] [] [] [] +s_1111[er] C12H21O14P C12H23O14P -2 0 MNXM61129 r_0599 [] H2 s_1111[er]: changed metFormula C12H21O14P to C12H23O14P to balance equation | changed metCharges -2 to 0 to balance equation "| metFormula in MNX database (C12H21O14P) with metCharge -2 is a conjugate base of mannose-1D-myo-inositol 1-phosphate (1-16:0, 2-18:1)(C12H23O14P)" [] | Changes based on metFormula in CHEBI:60448 [] +s_0847[c] C6H12NOR C6H13NOR 0 1 MNXM89832 r_0665; r_0666 MNXR100820 [] s_0847[c]: changed metFormula C6H12NOR to C6H13NOR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID ISOLEUCINE--TRNA-LIGASE-RXN +s_1596[c] R RH 0 [] MNXM90879 r_0665; r_0666 MNXR100820 [] s_1596[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID ISOLEUCINE--TRNA-LIGASE-RXN +s_0678[m] C5H9NO5 C5H8NO5 0 -1 MNXM923 r_0672 MNXR102616 H-1 s_0678[m]: changed metFormula C5H9NO5 to C5H8NO5 to balance equation | changed metCharges 0 to -1 to balance equation [] [] [] [] +s_0960[c] C3H4NO3 C3H5NO3 -1 0 MNXM2124 r_0690 MNXR101242 H1 s_0960[c]: changed metFormula C3H4NO3 to C3H5NO3 to balance equation | changed metCharges -1 to 0 to balance equation | based on metFormula in MNXM2124 [] [] [] +s_1196[c] C10H11NO4 C10H10NO4 0 -1 MNXM63755 r_0695 MNXR104994 H-1 s_1196[c]: changed metFormula C10H11NO4 to C10H10NO4 to balance equation | changed metCharges 0 to -1 to balance equation [] [] [] [] +s_1077[c] C6H12NOR C6H13NOR 0 1 MNXM697 r_0701; r_0702 MNXR101053 [] s_1077[c]: changed metFormula C6H12NOR to C6H13NOR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID LEUCINE--TRNA-LIGASE-RXN +s_1598[c] R RH 0 [] MNXM90880 r_0701; r_0702 MNXR101053 [] s_1598[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID LEUCINE--TRNA-LIGASE-RXN +s_0013[c] C20H32O4 C20H31O4 0 -1 MNXM31306 r_0703; r_0704 [] H-1 s_0013[c]: changed metFormula C20H32O4 to C20H31O4 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM31306 [] [] [] +s_0608[c] C20H32O4 C20H31O4 0 -1 MNXM507621 r_0705; r_0706 [] H-1 s_0608[c]: changed metFormula C20H32O4 to C20H31O4 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM507621 [] [] [] +s_1099[c] C6H14N2OR C6H15N2OR 0 2 MNXM89922 r_0711; r_0712 MNXR101264 s_1099[c]: changed metFormula C6H14N2OR to C6H15N2OR to balance equation | changed metCharges 0 to 2 to balance equation [] [] [] | Reference to BioCycID LYSINE--TRNA-LIGASE-RXN +s_1600[c] R RH 0 [] MNXM90881 r_0711; r_0712 MNXR101264 s_1600[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID LYSINE--TRNA-LIGASE-RXN +s_0785[c] C10H13N5O14P3 C10H12N5O14P3 -3 -4 MNXM51 r_0722 MNXR101375 H1 s_0785[c]: changed metFormula C10H13N5O14P3 to C10H12N5O14P3 to balance equation | changed metCharges -3 to -4 to balance equation [] [] [] [] +s_0574[c] C6H13O9P C6H11O9P 0 -2 MNXM427 r_0723 MNXR106679 H2 s_0574[c]: changed metFormula C6H13O9P to C6H11O9P to balance equation | changed metCharges 0 to -2 to balance equation [] [] [] [] +s_1488[m] C19H23N7O6 C19H21N7O6 0 -2 MNXM79 r_0728 MNXR124973 H-3 s_1488[m]: changed metFormula C19H23N7O6 to C19H21N7O6 to balance equation | changed metCharges 0 to -2 to balance equation [] [] [] [] +s_1148[c] C5H10NOSR C5H11NOSR 0 1 MNXM90636 r_0729; r_0730 MNXR101488 s_1148[c]: changed metFormula C5H10NOSR to C5H11NOSR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID METHIONINE--TRNA-LIGASE-RXN/RXN-16165 +s_1602[c] R RH 0 [] MNXM90882 r_0729; r_0730 MNXR101488 s_1602[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID METHIONINE--TRNA-LIGASE-RXN/RXN-16165 +s_1185[c] C20H20N2O8 C20H22N2O8 0 -2 MNXM147516 r_0763 MNXR101947 H2 s_1185[c]: changed metFormula C20H20N2O8 to C20H22N2O8 to balance equation | changed metCharges 0 to -2 to balance equation [] [] [] [] +s_0591[c] C21H27N6O15P2 C21H24N6O15P2 1 -2 MNXM309 r_0768 MNXR97678 H3 s_0591[c]: changed metFormula C21H27N6O15P2 to C21H24N6O15P2 to balance equation | changed metCharges 1 to -2 to balance equation | based on metFormula in MNXM309 [] [] [] +s_0593[n] C21H27N6O15P2 C21H24N6O15P2 1 -2 MNXM309 r_0769 MNXR97678 H3 s_0593[n]: changed metFormula C21H27N6O15P2 to C21H24N6O15P2 to balance equation | changed metCharges 1 to -2 to balance equation | based on metFormula in MNXM309 [] [] [] +s_0617[c] C10H13N5O13P3 C10H12N5O13P3 -3 -4 MNXM344 r_0798 MNXR96118 H-1 s_0617[c]: changed metFormula C10H13N5O13P3 to C10H12N5O13P3 to balance equation | changed metCharges -3 to -4 to balance equation | based on metFormula in MNXM344 [] [] [] +s_0650[c] C10H14N2O14P3 C10H13N2O14P3 -3 -4 MNXM394 r_0799 MNXR101937 H-1 s_0650[c]: changed C10H14N2O14P3 to C10H13N2O14P3 to balance equation | based on metFormula in MNXM394 [] [] [] +s_0618[c] C10H14N4O10P2 C10H11N4O10P2 0 -3 MNXM2174 r_0802 MNXR101934 H3 s_0618[c]: changed metFormula C10H14N4O10P2 to C10H11N4O10P2 to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in MNXM2174 [] [] [] +s_1411[m] C12H21NO4S2 C12H20NO4S2 0 -1 MNXM3710 r_0831 MNXR95656 H1 s_1411[m]: changed metFormula C12H21NO4S2 to C12H20NO4S2 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM3710 [] [] [] +s_0017[c] C9H18NO8P C9H15NO8P 0 -3 MNXM415 r_0842 MNXR103050 H-3 s_0017[c]: changed metFormula C9H18NO8P to C9H15NO8P to balance equation | changed metCharges 0 to -3 to balance equation | based on metFormula in MNXM415 [] [] [] +s_1314[c] C9H10NOR C9H11NOR 0 1 MNXM89802 r_0852; r_0853 MNXR102634 [] s_1314[c]: changed metFormula C9H10NOR to C9H11NOR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID PHENYLALANINE--TRNA-LIGASE-RXN +s_1604[c] R RH 0 [] MNXM90753 r_0852; r_0853 MNXR102634 [] s_1604[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID PHENYLALANINE--TRNA-LIGASE-RXN +s_1189[c] C8H16NO9P C8H14NO9P 0 -2 MNXM340 r_0882 MNXR111765 H-2 s_1189[c]: changed metFormula C8H16NO9P to C8H14NO9P to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM340 [] [] [] +s_0555[c] C6H14O12P2 C6H10O12P2 0 -4 MNXM500 r_0886 MNXR106666 H-4 s_0555[c]: changed metFormula C6H14O12P2 to C6H10O12P2 to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_0412[c] C6H14NO8P C6H13NO8P 0 -1 MNXM162238 r_0890 MNXR102526 H-1 s_0412[c]: changed metFormula C6H14NO8P to C6H13NO8P to balance equation | changed metCharges 0 to -1 to balance equation [] [] [] [] +s_0573[c] C6H13O9P C6H11O9P 0 -2 MNXM721 r_0902 MNXR101729 H2 s_0573[c]: changed metFormula C6H13O9P to C6H11O9P to balance equation | changed metCharges 0 to -2 to balance equation [] [] [] [] +s_1408[c] C5H11O8P C5H9O8P 0 -2 MNXM15900 r_0907 MNXR103115 H-2 s_1408[c]: changed metFormula C5H11O8P to C5H9O8P to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM15900 [] [] [] +s_1364[c] C9H11N3O9P C9H12N3O9P -3 -2 MNXM507 r_0911 MNXR108735 H2 s_1364[c]: changed metFormula C9H11N3O9P to C9H12N3O9P to balance equation | changed metCharges -3 to -2 to balance equation [] [] [] [] +s_1366[er] C18H39NO3 C18H40NO3 0 1 MNXM914 r_0920; r_0922 MNXR110323 O1H1 s_1366[er]: changed metFormula C18H39NO3 to C18H40NO3 to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] [] +s_1379[c] C5H8NOR C5H9NOR 0 1 MNXM247 r_0941 MNXR103208 [] s_1379[c]: changed C5H8NOR to C5H9NOR to balance equation [] [] [] | Reference to BioCycID PROLINE--TRNA-LIGASE-RXN +s_1606[c] R RH [] 0 MNXM90667 r_0941 MNXR103208 [] s_1606[c]: changed metFormula R to RH to balance equation | changed metCharges [] to 0 to balance equation [] [] [] | Reference to BioCycID PROLINE--TRNA-LIGASE-RXN +s_0590[c] C9H13N3O13P3 C9H12N3O13P3 -3 -4 MNXM360 r_0971 MNXR104076 N-1H-2R-2 s_0590[c]: changed metFormula C9H13N3O13P3 to C9H12N3O13P3 to balance equation | changed metCharges -3 to -4 to balance equation [] [] [] [] +s_1616[c] C6H9NO2S2R2 C6H10N2O2S2R4 0 0 MNXM96993 r_0971; r_0972; r_0973; r_0974; r_0976; r_0978; r_1038; r_4186; r_4202; r_0975 MNXR104070 N-1H-1R-2 s_1616[c]: changed metFormula C6H9NO2S2R2 to C6H10N2O2S2R4 to balance equation | changed metCharges 0 to 0 to balance equation [] [] [] [] +s_1620[c] C6H8N2O2S2R4 C6H9N2O2S2R4 0 1 MNXM148 r_0971; r_0972; r_0973; r_0974; r_0976; r_0978; r_1038; r_4186; r_4202; r_0975 MNXR104070 N-1H-1R-2 s_1620[c]: changed metFormula C6H8N2O2S2R4 to C6H9N2O2S2R4 to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] [] +s_0656[c] C9H12N2O14P3 C9H11N2O14P3 -3 -4 MNXM452 r_0973 MNXR104079 N-1H-2R-2 s_0656[c]: changed metFormula C9H12N2O14P3 to C9H11N2O14P3 to balance equation | changed metCharges -3 to -4 to balance equation [] [] [] [] +s_1618[n] C6H9NO2S2R2 C6H10N2O2S2R4 0 [] MNXM96993 r_0975; r_0977; r_0979 MNXR104060 N-1H-1R-2 s_1618[n]: changed C6H9NO2S2R2 to C6H10N2O2S2R4 to balance equation [] [] [] [] +s_1622[n] C6H8N2O2S2R4 C6H9N2O2S2R4 0 1 MNXM148 r_0975; r_0977; r_0979 MNXR104060 N-1H-1R-2 s_1622[n]: changed metFormula C6H8N2O2S2R4 to C6H9N2O2S2R4 to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] [] +s_1428[c] C3H6NO2R C3H7NO2R 0 1 MNXM165150 r_0995 MNXR104350 [] s_1428[c]: changed metFormula C3H6NO2R to C3H7NO2R to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID SERINE--TRNA-LIGASE-RXN +s_1607[c] R RH [] 0 MNXM91028 r_0995 MNXR104350 [] s_1607[c]: changed metFormula R to RH to balance equation | changed metCharges [] to 0 to balance equation [] [] [] | Reference to BioCycID SERINE--TRNA-LIGASE-RXN +s_1367[er] C18H40NO6P C18H39NO6P 0 -1 MNXM3337 r_1004; r_1006 MNXR104281 H1 s_1367[er]: changed metFormula C18H40NO6P to C18H39NO6P to balance equation | changed metCharges 0 to -1 to balance equation [] [] [] [] +s_1469[c] HO3S O3S -1 -2 MNXM105630 r_1027 MNXR104650 H1 s_1469[c]: changed metFormula HO3S to O3S to balance equation | changed metCharges -1 to -2 to balance equation | based on metFormula in MNXM105630 [] [] [] +s_0308[c] C24H30N8O9 C24H27N8O9 0 -3 MNXM723480 r_1031 MNXR143412 H-1 s_0308[c]: changed metFormula C24H30N8O9 to C24H27N8O9 to balance equation | changed metCharges 0 to -3 to balance equation [] [] [] [] +s_1476[e] C12H18N4O7P2S C12H16N4O7P2S 0 -2 MNXM256 r_1032 MNXR138860 H2 s_1476[e]: changed metFormula C12H18N4O7P2S to C12H16N4O7P2S to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM256 [] [] [] +s_1498[e] C12H18N4O4PS C12H16N4O4PS 1 -1 MNXM662 r_1033 MNXR104823 H2 s_1498[e]: changed metFormula C12H18N4O4PS to C12H16N4O4PS to balance equation | changed metCharges 1 to -1 to balance equation | based on metFormula in MNXM662 [] [] [] +s_1475[c] C12H18N4O7P2S C12H16N4O7P2S 0 -2 MNXM256 r_1034 MNXR104886 H-2 s_1475[c]: changed metFormula C12H18N4O7P2S to C12H16N4O7P2S to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM256 [] [] [] +s_1497[c] C12H18N4O4PS C12H16N4O4PS 1 -1 MNXM662 r_1036 MNXR104908 H-2 s_1497[c]: changed metFormula C12H18N4O4PS to C12H16N4O4PS to balance equation | changed metCharges 1 to -1 to balance equation | based on metFormula in MNXM662 [] [] [] +s_1617[m] C6H9NO2S2R2 C6H10N2O2S2R4 0 0 MNXM96993 r_1039 MNXR104766 N1H1R2 s_1617[m]: changed metFormula C6H9NO2S2R2 to C6H10N2O2S2R4 to balance equation | changed metCharges 0 to 0 to balance equation [] [] [] [] +s_1621[m] C6H8N2O2S2R4 C6H9N2O2S2R4 0 1 MNXM148 r_1039 MNXR104766 N1H1R2 s_1621[m]: changed metFormula C6H8N2O2S2R4 to C6H9N2O2S2R4 to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] [] +s_1491[c] C4H8NO2R C4H9NO2R 0 1 MNXM89895 r_1042; r_1043 MNXR104848 [] s_1491[c]: changed metFormula C4H8NO2R to C4H9NO2R to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID THREONINE--TRNA-LIGASE-RXN +s_1608[c] R RH 0 [] MNXM90883 r_1042; r_1043 MNXR104848 [] | s_1469[c]: changed HO3S to O3S to balance equation [] [] [] | Reference to BioCycID THREONINE--TRNA-LIGASE-RXN +s_0649[c] C10H15N2O8P C10H13N2O8P 0 -2 MNXM257 r_1045 MNXR104889 H-2 s_0649[c]: changed metFormula C10H15N2O8P to C10H13N2O8P to balance equation | changed metCharges 0 to -2 to balance equation [] [] [] [] +s_1527[c] C11H11N2OR C11H12N2OR 0 1 MNXM89804 r_1057; r_1058 MNXR104948 [] s_1527[c]: changed metFormula C11H11N2OR to C11H12N2OR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID TRYPTOPHAN--TRNA-LIGASE-RXN +s_1610[c] R RH 0 [] MNXM90755 r_1057; r_1058 MNXR104948 [] s_1610[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID TRYPTOPHAN--TRNA-LIGASE-RXN +s_1533[c] C9H10NO2R C9H11NO2R 0 1 MNXM89822 r_1066; r_1067 MNXR105001 [] s_1533[c]: changed metFormula C9H10NO2R to C9H11NO2R to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID TYROSINE--TRNA-LIGASE-RXN +s_1612[c] R RH 0 [] MNXM90668 r_1066; r_1067 MNXR105001 [] s_1612[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID TYROSINE--TRNA-LIGASE-RXN +s_1561[c] C5H10NOR C5H11NOR 0 1 MNXM90110 r_1089; r_1090 MNXR105186 [] s_1561[c]: changed metFormula C5H10NOR to C5H11NOR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to BioCycID VALINE--TRNA-LIGASE-RXN +s_1614[c] R RH 0 [] MNXM90885 r_1089; r_1090 MNXR105186 [] s_1614[c]: changed R to RH to balance equation [] [] [] | Reference to BioCycID VALINE--TRNA-LIGASE-RXN +s_2763[c] C10H7NO3 C10H6NO3 0 -1 MNXM1113 r_2112 MNXR132503 O1H1 s_2763[c]: changed metFormula C10H7NO3 to C10H6NO3 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM1113 [] [] [] +s_2764[c] C10H7NO2 [] 0 [] MNXM4797 r_2113 MNXR108341 [] s_2764[c]: changed metFormula C10H7NO2 to [] to balance equation | changed metCharges 0 to -1 to balance equation [] [] [] [] +s_2777[m] C18H35O2S C8H15O2SR 0 [] MNXM10033 r_2147; r_2150 MNXR137225 C-10H-20R1 s_2777[m]: changed C18H35O2S to C8H15O2SR to balance equation | based on metFormula in seed:cpd16857 (linked to MNXM10033) [] [] [] +s_2778[m] C4H5OS C4H5OSR 0 [] [] r_2148 [] R1 s_2778[m]: changed metFormula C4H5OS to C4H5OSR to balance equation [] [] [] [] +s_2792[erm] C41H72N7O18P3S C41H68N7O18P3S 0 -4 MNXM36762 r_2157 MNXR103450 H-4 s_2792[erm]: changed metFormula C41H72N7O18P3S to C41H68N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM36762 [] [] [] +s_2795[erm] C43H78N7O17P3S C43H74N7O17P3S 0 -4 MNXM10780 r_2159 [] H4 s_2795[erm]: changed metFormula C43H78N7O17P3S to C43H74N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM10780 [] [] [] +s_2801[erm] C35H62N7O18P3S C35H58N7O18P3S 0 -4 MNXM767 r_2161 [] H-4 s_2801[erm]: changed metFormula C35H62N7O18P3S to C35H58N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM767 [] [] [] +s_2802[erm] C37H66N7O18P3S C37H62N7O18P3S 0 -4 MNXM825 r_2162 [] H-4 s_2802[erm]: changed metFormula C37H66N7O18P3S to C37H62N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM825 [] [] [] +s_2803[erm] C39H70N7O18P3S C39H66N7O18P3S 0 -4 MNXM1309 r_2163 MNXR103465 H-4 s_2803[erm]: changed metFormula C39H70N7O18P3S to C39H66N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM1309 [] [] [] +s_2804[erm] C41H74N7O18P3S C41H70N7O18P3S 0 -4 MNXM146349 r_2164 MNXR103451 H-4 s_2804[erm]: changed metFormula C41H74N7O18P3S to C41H70N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM146349 [] [] [] +s_2810[erm] C37H64N7O17P3S C37H60N7O17P3S 0 -4 MNXM581 r_2169; r_2176 [] H-4 s_2810[erm]: changed metFormula C37H64N7O17P3S to C37H60N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM581 [] [] [] +s_2813[erm] C33H56N7O17P3S C43H72N7O17P3S 0 -4 MNXM97615 r_2172; r_2179; r_2240; r_2258 [] C10H16 s_2813[erm]: changed metFormula C33H56N7O17P3S to C43H72N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM97615 [] [] [] +s_2805[erm] C43H78N7O18P3S C43H74N7O18P3S 0 -4 MNXM162568 r_2172; r_2258 [] C10H16 s_2805[erm]: changed metFormula C43H78N7O18P3S to C43H74N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM162568 [] [] [] +s_2806[erm] C45H82N7O18P3S C45H78N7O18P3S 0 -4 MNXM36558 r_2173 MNXR118009 H4 s_2806[erm]: changed metFormula C45H82N7O18P3S to C45H78N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_2807[erm] C47H86N7O18P3S C47H82N7O18P3S 0 -4 MNXM31741 r_2174; r_2253 (s_0045[p]) [] H-4 s_2807[erm]: changed metFormula C47H86N7O18P3S to C47H82N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_2812[erm] C41H72N7O17P3S C41H68N7O17P3S 0 -4 MNXM22115 r_2178; r_2239 [] H4 s_2812[erm]: changed metFormula C41H72N7O17P3S to C41H68N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM22115 [] [] [] +s_2861[ce] C41H74N7O17P3S C41H70N7O17P3S 0 -4 MNXM1429 r_2209 [] H-4 s_2861[ce]: changed metFormula C41H74N7O17P3S to C41H70N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM1429 [] [] [] +s_2863[ce] C43H78N7O17P3S C43H74N7O17P3S 0 -4 MNXM10780 r_2210 [] H-4 s_2863[ce]: changed metFormula C43H78N7O17P3S to C43H74N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM10780 [] [] [] +s_2872[lp] C43H78N7O17P3S C43H74N7O17P3S 0 -4 MNXM10780 r_2216 [] H-4 s_2872[lp]: changed metFormula C43H78N7O17P3S to C43H74N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM10780 [] [] [] +s_2888[p] C29H48N7O17P3S C29H44N7O17P3S 0 -4 MNXM784 r_2238 [] H-4 s_2888[p]: changed metFormula C29H48N7O17P3S to C29H44N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM784 [] [] [] +s_2881[p] C43H78N7O17P3S C43H74N7O17P3S 0 -4 MNXM10780 r_2240 [] C10H20 s_2881[p]: changed metFormula C43H78N7O17P3S to C43H74N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM10780 [] [] [] +s_2891[p] C45H80N7O17P3S C45H76N7O17P3S 0 -4 MNXM97616 r_2241; r_2180 (s_2814[erm]) MNXR127548 H-4 s_2891[p]: changed metFormula C45H80N7O17P3S to C45H76N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_2896[p] C35H54N7O17P3S C33H54N7O17P3S 0 [] [] r_2244 [] C2 "| trans-2,cis-5-dodecadienoyl-CoA, with 2 C=C double bonds in dienoyl-CoA, should only have 2 less H atoms as compared to cis-dodec-5-enoyl-CoA, with 1 C=C double bond in enoyl-CoA" [] [] "| metFormula deduced with reference to ChEBIID CHEBI:139121 ((3E,5Z)-dodecadienoyl-CoA)" [] +s_2897[p] C39H66N7O17P3S C39H62N7O17P3S 0 -4 MNXM638 r_2245 [] H-4 s_2897[p]: changed metFormula C39H66N7O17P3S to C39H62N7O17P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM638 [] [] [] +s_0042[p] C31H54N7O18P3S C31H50N7O18P3S 0 -4 MNXM674 r_2248 MNXR97889 H-4 s_0042[p]: changed metFormula C31H54N7O18P3S to C31H50N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM674 [] [] [] +s_0048[p] C33H58N7O18P3S C33H54N7O18P3S 0 -4 MNXM733 r_2249 MNXR97890 H-4 s_0048[p]: changed metFormula C33H58N7O18P3S to C33H54N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM733 [] [] [] +s_0051[p] C37H66N7O18P3S C37H62N7O18P3S 0 -4 MNXM825 r_2251 MNXR97892 H-4 s_0051[p]: changed metFormula C37H66N7O18P3S to C37H62N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM825 [] [] [] +s_0229[p] C39H70N7O18P3S C39H66N7O18P3S 0 -4 MNXM1309 r_2252 MNXR103466 H-4 s_0229[p]: changed metFormula C39H70N7O18P3S to C39H66N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM1309 [] [] [] +s_2887[p] C27H40N7O17P3S C27H44N7O17P3S -4 0 MNXM753 r_2255 [] H-4 s_2887[p]: changed metFormula C27H40N7O17P3S to C27H44N7O17P3S to balance equation | changed metCharges -4 to 0 to balance equation | metFormula in MNX database (C27H40N7O17P3S) with metCharge -4 is a conjugate base of trans-hex-2-enoyl-CoA (C27H44N7O17P3S) [] | Verified via reference to ChEBIID CHEBI:28706 [] +s_2907[p] C45H82N7O18P3S C45H78N7O18P3S 0 -4 MNXM36558 r_2259 MNXR118009 H-4 s_2907[p]: changed metFormula C45H82N7O18P3S to C45H78N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_2892[p] C37H58N7O17P3S C37H62N7O17P3S -4 0 MNXM10467 r_2260 [] C-2H-8 s_2892[p]: changed metFormula C37H58N7O17P3S to C37H62N7O17P3S to balance equation | changed metCharges -4 to 0 to balance equation "| metFormula in MNX database (C37H58N7O17P3S) with metCharge -4 is a conjugate base of trans-2,cis-9-hexadecadienoyl-CoA (C37H62N7O17P3S)" [] | Verified via reference to ChEBIID CHEBI:78178 [] +s_2908[p] C39H68N7O18P3S C37H64N7O18P3S 0 [] [] r_2260; r_2277 [] C2O1H2 "| 3-hydroxy, in IUPAC nomenclature, indicates an ""-OH"" functional group bonded to carbon-3 of the S-acyl group i.e. (R)-3-hydroxy-cis-hexadec-9-enoyl-CoA should have 2 more H atoms compared to 3-oxo-cis-hexadec-9-enoyl-CoA (C37H62N7O18P3S, which has an ""=O"" group bonded to the same numbered carbon)" [] [] "| metFormula deduced with reference to ChEBIID CHEBI:88087 ((3S,7Z)-3-hydroxyhexadecenoyl-CoA, an isomer)" [] +s_2911[p] C39H68N7O18P3S C39H64N7O18P3S 0 -4 MNXM149457 r_2263; r_2280 [] H-4 s_2911[p]: changed metFormula C39H68N7O18P3S to C39H64N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM149457 [] [] [] +s_2902[p] C25H42N7O18P3S C25H38N7O18P3S 0 -4 MNXM1058 r_2271 [] H4 s_2902[p]: changed metFormula C25H42N7O18P3S to C25H38N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM1058 [] [] [] +s_2905[p] C41H74N7O18P3S C41H70N7O18P3S 0 -4 MNXM36530 r_2274 [] H4 s_2905[p]: changed metFormula C41H74N7O18P3S to C41H70N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM36530 [] [] [] +s_2918[p] C43H76N7O18P3S C43H72N7O18P3S 0 -4 MNXM36756 r_2275 [] H-4 s_2918[p]: changed metFormula C43H76N7O18P3S to C43H72N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation | based on metFormula in MNXM36756 [] [] [] +s_2919[p] C45H80N7O18P3S C45H76N7O18P3S 0 -4 MNXM36773 r_2276 [] H-4 s_2919[p]: changed metFormula C45H80N7O18P3S to C45H76N7O18P3S to balance equation | changed metCharges 0 to -4 to balance equation [] [] [] [] +s_2920[p] C37H64N7O17P3S C37H62N7O18P3S 0 [] [] r_2277; r_2289 [] O-1H2 "| 3-oxo, in IUPAC nomenclature, indicates an ""=O"" group bonded to carbon-3 of the S-acyl group i.e. 3-oxo-cis-hexadec-9-enoyl-CoA should have -2C and 1O as compared to hexadecenoyl-CoA (C37H64N7O17P3S)" [] [] "| metFormula deduced with reference to ChEBIID CHEBI:53152/CHEBI:24549 (hexadecenoyl-CoA) and CHEBI:88090 ((7Z)-3-oxohexadecenoyl-CoA, an isomer)" [] +s_2909[p] [] C35H60N7O18P3S 0 [] [] r_2278 [] no metFormula for (R)-3-hydroxy-cis-tetradec-7-enoyl-CoA "| 3-hydroxy, in IUPAC nomenclature, indicates an ""-OH"" functional group bonded to carbon-3 of the S-acyl group i.e. (R)-3-hydroxy-cis-tetradec-7-enoyl-CoA should have 2 more H atoms compared to 3-oxo-cis-tetradec-7-enoyl-CoA (C35H58N7O18P3S, which has an ""=O"" group bonded to the same numbered carbon)" [] [] [] [] +s_2921[p] C35H60N7O17P3S C35H58N7O18P3S 0 [] [] r_2278; r_2290 [] O-1H2 "| 3-oxo, in IUPAC nomenclature, indicates an ""=O"" group bonded to carbon-3 of the S-acyl group i.e. 3-oxo-cis-tetradec-7-enoyl-CoA should have -2C and 1O as compared to cis-tetradec-11-enoyl-CoA (C35H60N7O17P3S)" [] [] "| metFormula deduced with reference to ChEBIID CHEBI:15461(cis-tetradec-11-enoyl-CoA) and CHEBI:88080 ((5Z)-3-oxotetradecenoyl-CoA, an isomer)" [] +s_2910[p] [] C33H56N7O18P3S 0 [] [] r_2279 [] no metFormula for (R)-3-hydroxy-cis-dodec-5-enoyl-CoA "| 3-hydroxy, in IUPAC nomenclature, indicates an ""-OH"" functional group bonded to carbon-3 of the S-acyl group i.e. (R)-3-hydroxy-cis-dodec-5-enoyl-CoA should have 2 more H atoms compared to 3-oxo-cis-dodec-5-enoyl-CoA (C33H54N7O18P3S, which has an ""=O"" group bonded to the same numbered carbon)" [] [] [] [] +s_2922[p] [] C33H54N7O18P3S 0 [] [] r_2279; r_2291 [] no metFormula for 3-oxo-cis-dodec-5-enoyl-CoA "| 3-oxo, in IUPAC nomenclature, indicates an ""=O"" group bonded to carbon-3 of the S-acyl group i.e. 3-oxo-cis-dodec-5-enoyl-CoA should have -2C and 1O as compared to dodecenoyl-CoA and cis-dodec-3-enoyl-CoA (C33H56N7O17P3S)" [] [] | metFormula deduced with reference to ChEBIID CHEBI:23869 (odecenoyl-CoA) and CHEBI:27989 (cis-dodec-3-enoyl-CoA) [] +s_2911[p] C39H64N7O18P3S C39H68N7O18P3S -4 0 MNXM149457 r_2280 [] H-4 "| 3-hydroxy, in IUPAC nomenclature, indicates an ""-OH"" functional group bonded to carbon-3 of the S-acyl group i.e. (R)-3-hydroxy-cis-octadec-9-enoyl-CoA should have 2 more H atoms compared to 3-oxo-cis-octadec-9-enoyl-CoA (C39H66N7O18P3S, which has an ""=O"" group bonded to the same numbered carbon)" | metFormula in MNX database (C39H64N7O18P3S) with metCharge -4 is a conjugate base of (R)-3-hydroxy-cis-octadec-9-enoyl-CoA (C39H68N7O18P3S) [] | Verified via reference to ChEBIID CHEBI:87781 [] +s_2917[p] C41H72N7O18P3S C41H68N7O18P3S 0 -4 MNXM36762 r_2286 [] H4 | s_2917[p]: changed C41H72N7O18P3S to C41H68N7O18P3S to balance equation | based on metFormula in MNXM36762 [] [] [] +s_2923[p] C39H68N7O17P3S C39H66N7O18P3S 0 [] [] r_2292 [] O-1H2 "| 3-oxo, in IUPAC nomenclature, indicates an ""=O"" group bonded to carbon-3 of the S-acyl group i.e. 3-oxo-cis-octadec-9-enoyl-CoA should have -2C and 1O as compared to trans-9-octadecenoyl-CoA (C39H68N7O17P3S)" [] [] | metFormula deduced with reference to ChEBIID CHEBI:78146 (trans-9-octadecenoyl-CoA) and CHEBI:76896 ((11Z)-3-oxooctadecenoyl-CoA) [] +s_2924[p] C37H64N7O17P3S C37H62N7O18P3S 0 [] MNXM150996 r_2293 [] O-1H2 "| 3-oxo, in IUPAC nomenclature, indicates an ""=O"" group bonded to carbon-3 of the S-acyl group i.e. 3-oxo-cis-hexadec-7-enoyl-CoA should have -2C and 1O as compared to hexadecenoyl-CoA (C37H64N7O17P3S)" | metFormula in MNX database (C37H58N7O18P3S) with metCharge -4 is a conjugate base of cis-tetradec-5-enoyl-CoA (C37H62N7O18P3S) [] | Changes based on ChEBIID CHEBI:88090 [] +s_2925[p] C35H60N7O17P3S C35H58N7O18P3S 0 [] MNXM147795 r_2294 [] O-1H2 "| 3-oxo, in IUPAC nomenclature, indicates an ""=O"" group bonded to carbon-3 of the S-acyl group i.e. 3-oxo-cis-tetradec-5-enoyl-CoA should have -2C and 1O as compared to cis-tetradec-11-enoyl-CoA (C35H60N7O17P3S)" | metFormula in MNX database (C35H54N7O18P3S) with metCharge -4 is a conjugate base of cis-tetradec-5-enoyl-CoA (C35H60N7O17P3S) [] | Changes based on ChEBIID CHEBI:88080 [] +s_2933[p] C35H54N7O17P3S C35H58N7O17P3S 0 [] MNXM147629 r_2302 [] H4 "| all related reactions (r_2302, 2304) can be corrected by adding 4 H atoms to old trans-2,trans-4-tetradecadienoyl-CoA metFormula" [] [] | Verified via ChEBIID CHEBI:88084 [] +s_2941[erm] C19H35O7P [] -2 0 [] r_2313 [] H-2 | metFormula determined based on acylglycerone phosphate (16:0) (C19H35O7P) [] [] [] [] +s_2942[erm] C21H39O7P C21H41O7P -2 0 MNXM33006 r_2314 [] [] s_2942[erm]: changed metFormula C21H39O7P to C21H41O7P to balance equation | changed metCharges -2 to 0 to balance equation | metFormula in MNX database (C21H39O7P) with metCharge -2 is a conjugate base of acylglycerone phosphate (18:0) (C21H41O7P) | Verified based on KEGGID C03805 | Verified based on CHEBI:36476 [] +s_2943[erm] C35H65O8P C21H39O7P 0 [] MNXM32961 r_2315 [] C-14O-1H-28 s_2943[erm]: changed C35H65O8P to C21H39O7P to balance equation | metFormula in MNX database (C21H37O7P) with metCharge -2 is a conjugate base of acylglycerone phosphate (18:1) (C21H39O7P) | Verified based on KEGGID C03630 | Verified based on ChEBIID CHEBI:36475 [] +s_2935[erm] C19H37O7P C19H39O7P -2 0 MNXM2455 r_2332 [] H-2 "| Conjugate acid of phosphatidate C19H39O7P is most likely to be predominant due to the neutral ? acidic conditions in the compartments where reaction occurs (erm, vm, gm); reference literature: https://doi.org/10.1038/s41598-018-30367-z" | metFormula in MNX database (C19H37O7P) with metCharge -2 is a conjugate base of 1-acyl-sn-glycerol 3-phosphate (C19H39O7P) [] | based on metFormula in model ChEBIID CHEBI:15799 [] +s_2936[erm] C19H35O7P C19H37O7P -2 0 MNXM66496 r_2334 [] H-2 "| Conjugate acid of phosphatidate C19H37O7P is most likely to be predominant due to the neutral � acidic conditions in the compartments where reaction occurs (erm, vm, gm); reference literature: https://doi.org/10.1038/s41598-018-30367-z" | metFormula in MNX database (C19H35O7P) with metCharge -2 is a conjugate base of 1-acyl-sn-glycerol 3-phosphate (C19H37O7P) [] | based on metFormula in model ChEBIID CHEBI:75070 [] +s_2954[erm] C35H65O8P C35H67O8P -2 0 MNXM66470 r_2344 [] H-2 "| Conjugate acid of phosphatidate C35H67O8P is most likely to be predominant due to the neutral ? acidic conditions in the compartments where reaction occurs (erm, vm, gm); reference literature: https://doi.org/10.1038/s41598-018-30367-z" "| metFormula in MNX database (C35H65O7P) with metCharge -2 is a conjugate base of phosphatidate (1-16:0, 2-16:1) (C35H67O8P)" [] [] | Reference to LMGP10010911 +s_2967[erm] C35H68O5 C35H66O5 0 [] MNXM49375 r_2344 [] H-2 "| Incorrect metFormula of diglyceride (1-16:0, 2-16:0) (C35H68O5) was previously registered" | based on metFormula in MNXM49375 [] [] [] +s_2955[erm] C37H71O8P C37H69O8P 0 -2 MNXM66476 r_2345 [] H2 s_2955[erm]: changed metFormula C37H71O8P to C37H69O8P to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM66476 [] [] [] +s_3090[erm] C48H83N3O15P2 C48H87N3O15P2 0 [] [] r_2438 [] H4 "| metFormula determined based on CDP-diacylglycerol (1-16:0, 2-16:1) (C44H79N3O15P2)" [] [] [] | reference to LMGP13010015 +s_3088[erm] C46H83N3O15P2 C46H81N3O15P2 0 -2 MNXM32787 r_2450 [] H1 s_3088[erm]: changed metFormula C46H83N3O15P2 to C46H81N3O15P2 to balance equation | changed metCharges 0 to -2 to balance equation | based on metFormula in MNXM32787 [] [] [] +s_3126[erm] C25H41O12P C25H47O12P 0 [] [] r_2462 [] H-6 s_3126[erm]: changed C25H41O12P to C25H47O12P to balance equation [] [] | Changes based on ChEBIID CHEBI:138108 [] +s_3127[erm] C27H45O12P C27H51O12P 0 [] [] r_2463 [] H-6 s_3127[erm]: changed C27H45O12P to C27H51O12P to balance equation [] [] | Changes based on alternative ChEBIID CHEBI:90456 [] +s_3220[mm] C40H74O13P2 C38H74O13P2 0 [] [] r_2536 [] C-2H-1 "| metFormula determined based on 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1) (C42H76O13P2)" [] [] [] [] +s_3221[mm] C40H72O13P2 C38H72O13P2 0 [] [] r_2537 [] C-2H-1 "| metFormula determined based on 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1) (C42H76O13P2)" [] [] [] [] +s_3222[mm] C42H76O13P2 C40H78O13P2 0 [] [] r_2538 [] C-2H1 "| metFormula determined based on 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1) (C42H76O13P2)" [] [] [] [] +s_3223[mm] C42H74O13P2 C40H76O13P2 0 [] [] r_2539 [] C-2H1 "| metFormula determined based on 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1) (C42H76O13P2)" [] [] [] [] +s_3104[mm] C46H81N3O15P2 C46H83N3O15P2 -2 0 MNXM32787 r_2540 [] C-2H-1 "| metFormula determined based on CDP-diacylglycerol (1-16:0, 2-16:1) (C44H79N3O15P2)" "| metFormula in MNX database (C46H81N3O15P2) with metCharge -2 is a conjugate base of CDP-diacylglycerol (1-16:0, 2-18:1)(C46H83N3O15P2)" | Verified via current KEGGID C13892 | Verified via ChEBIID CHEBI:34077 [] +s_3224[mm] C42H76O13P2 C40H78O13P2 0 [] MNXM725269 r_2540 [] C-2H-1 "| based on reaction, this metabolite is deduced to be PGP (16:0, 18:1), a product formed when CDP-DAG reacts with G3P" | metFormula in MNX database (C40H75O13P2) with metCharge -3 is a conjugate base of 1-acyl-sn-glycerol 3-phosphate (C19H37O7P) [] [] | Changes based on reference to LMGP05010001 +s_3225[mm] C42H74O13P2 C40H76O13P2 0 [] [] r_2541 [] C-2H1 "| metFormula determined based on 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1) (C42H76O13P2)" [] [] [] [] +s_3234[mm] C73H140O17P2 C73H138O17P2 0 [] MNXM120766 r_2548 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" "| metFormula in MNX database (C73H136O17P2) with metCharge -2 is a conjugate base of cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1) (C73H138O17P2)" [] [] | Verified via reference to PubChem CID 131766957 +s_3236[mm] C75H144O17P2 C75H142O17P2 0 [] MNXM120785 r_2550 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" "| metFormula in MNX database (C75H140O17P2) with metCharge -2 is a conjugate base of cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1) (C75H142O17P2)" [] [] | Verified via reference to PubChem CID 131766967 +s_3238[mm] C75H144O17P2 C75H142O17P2 0 [] MNXM120768 r_2552 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" "| metFormula in MNX database (C75H140O17P2) with metCharge -2 is a conjugate base of cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1) (C75H142O17P2)" [] [] | Verified via reference to PubChem CID 131766959 +s_3240[mm] C73H138O17P2 C73H136O17P2 0 [] [] r_2554 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3242[mm] C75H142O17P2 C75H140O17P2 0 [] [] r_2556 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3244[mm] C75H142O17P2 C75H140O17P2 0 [] [] r_2558 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3246[mm] C75H144O17P2 C75H142O17P2 0 [] [] r_2560 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3248[mm] C77H148O17P2 C77H146O17P2 0 [] [] r_2562 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3250[mm] C77H148O17P2 C77H146O17P2 0 [] [] r_2564 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3252[mm] C75H142O17P2 C75H140O17P2 0 [] [] r_2566 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3254[mm] C77H146O17P2 C77H144O17P2 0 [] [] r_2568 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3256[mm] C77H146O17P2 C77H144O17P2 0 [] [] r_2570 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3258[mm] C75H144O17P2 C75H142O17P2 0 [] [] r_2572 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3260[mm] C77H148O17P2 C77H146O17P2 0 [] [] r_2574 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3262[mm] C77H148O17P2 C77H146O17P2 0 [] [] r_2576 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3264[mm] C75H142O17P2 C75H140O17P2 0 [] [] r_2578 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3266[mm] C77H146O17P2 C77H144O17P2 0 [] [] r_2580 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3268[mm] C77H146O17P2 C77H144O17P2 0 [] [] r_2582 [] H-1 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3308[mm] C77H146O17P2 C77H144O17P2 0 [] [] r_2672 [] H-2 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3310[mm] C79H150O17P2 C79H148O17P2 0 [] [] r_2688 [] H-2 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3312[mm] C79H150O17P2 C79H148O17P2 0 [] [] r_2704 [] H-2 "| Deduced with reference to s_3235 [mm], cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)" [] [] [] [] +s_3297[mm] C24H51NO7P C24H50NO7P 1 0 MNXM32510 r_2812 [] H1 s_3297[mm]: changed metFormula C24H51NO7P to C24H50NO7P to balance equation | changed metCharges 1 to 0 to balance equation | Changes based on reference to MNXM32510 [] | Changes based on reference to CHEBI:72998 | Changes based on reference to LMGP01050018 +s_3299[mm] C24H49NO7P C24H48NO7P 1 0 MNXM32519 r_2814 [] H1 s_3299[mm]: changed metFormula C24H49NO7P to C24H48NO7P to balance equation | changed metCharges 1 to 0 to balance equation | Changes based on reference to MNXM32519 [] | Changes based on reference to CHEBI:73851 | Changes based on reference to LMGP01050022 +s_3301[mm] C26H55NO7P C26H54NO7P 1 0 MNXM32545 r_2816 [] H1 s_3301[mm]: changed metFormula C26H55NO7P to C26H54NO7P to balance equation | changed metCharges 1 to 0 to balance equation | Changes based on reference to MNXM32545 [] | Changes based on reference to CHEBI:73858 | Changes based on reference to LMGP01050026 +s_3303[mm] C26H53NO7P C26H52NO7P 1 0 MNXM13872 r_2818 [] H1 s_3303[mm]: changed metFormula C26H53NO7P to C26H52NO7P to balance equation | changed metCharges 1 to 0 to balance equation | Changes based on reference to MNXM13872 [] | Changes based on reference to CHEBI:28610 | Changes based on reference to LMGP01050032 +s_3479[ce] C22H44NP10 C22H44NO9P 0 [] MNXM78597 r_3058 [] O9P-9 s_3479[ce]: changed C22H44NP10 to C22H44NO9P to balance equation | metFormula in MNX database (C22H43NO9P) with metCharge -1 is a conjugate base of 1-acylglycerophosphoserine (16:0) (C22H44NO9P) [] [] | Changes based on reference to LMGP03050002 +s_3481[ce] C22H42NP10 C22H42NO9P 0 [] MNXM78629 r_3059 [] O9P-9 s_3481[ce]: changed C22H42NP10 to C22H42NO9P to balance equation | metFormula in MNX database (C22H41NO9P) with metCharge -1 is a conjugate base of 1-acylglycerophosphoserine (16:1) (C22H42NO9P) [] [] | Changes based on reference to LMGP03050010 +s_3483[ce] C24H48NP10 C24H48NO9P 0 [] MNXM78757 r_3060 [] O9P-9 s_3483[ce]: changed C24H48NP10 to C24H48NO9P to balance equation | metFormula in MNX database (C24H47NO9P) with metCharge -1 is a conjugate base of 1-acylglycerophosphoserine (18:0) (C24H48NO9P) [] [] | Changes based on reference to LMGP03050006 +s_3485[ce] C24H46NP10 C24H46NO9P 0 [] MNXM32944 r_3061 [] O9P-9 s_3485[ce]: changed C24H46NP10 to C24H46NO9P to balance equation | metFormula in MNX database (C24H45NO9P) with metCharge -1 is a conjugate base of 1-acylglycerophosphoserine (18:1) (C24H46NO9P) [] [] | Changes based on reference to LMGP03050001 +s_3454[ce] C42H82NO7P C42H82NO8P 0 [] MNXM69528 r_3106 [] O-1H-2 "| metFormula determined based on phosphatidylcholine (1-16:1, 2-16:1) (C40H76NO8P)" | Verified via MNXMID MNXM69528 [] | Verified via ChEBIID CHEBI:86097 | Verified via reference to LMGP01010744 +s_3456[ce] C42H80NO7P C42H80NO8P 0 [] MNXM69658 r_3107 [] O-1H-2 "| metFormula determined based on phosphatidylcholine (1-16:1, 2-16:1) (C40H76NO8P)" | Verified via MNXMID MNXM69658 [] | Verified via ChEBIID CHEBI:86100 | Verified via reference to LMGP01010887 +s_3461[ce] C44H86NO7P C44H86NO8P 0 [] MNXM32526 r_3110 [] O-1H-2 "| metFormula determined based on phosphatidylcholine (1-16:1, 2-18:1) (C42H80NO8P)" | Verified via MNXMID MNXM32526 [] | Verified via ChEBIID CHEBI:75034 | Verified via reference to LMGP01010761 +s_3462[ce] C44H84NO7P C44H84NO8P 0 [] MNXM8549 r_3111 [] O-1H-2 "| metFormula determined based on phosphatidylcholine (1-16:1, 2-18:1) (C42H80NO8P)" | Verified via MNXMID MNXM8549 [] | Verified via ChEBIID CHEBI:74669 | Verified via reference to LMGP01010890 +s_2955[erm] C37H69O8P C37H71O8P -2 0 MNXM66476 r_3228 [] H3 "| Conjugate acid of phosphatidate C35H71O8P is most likely to be predominant due to the neutral ? acidic conditions in the compartments where reaction occurs (erm, vm, gm); reference literature: https://doi.org/10.1038/s41598-018-30367-z" "| metFormula in MNX database (C37H69O7P) with metCharge -2 is a conjugate base of phosphatidate (1-16:0, 2-18:1) (C37H71O8P)" [] [] | Reference to LMGP10010032 +s_3754[m] C20H28N6O13PR C5H8NO3R 0 [] MNXM91213 r_4155 [] [] s_3754[m]: changed C20H28N6O13PR to C5H8NO3R to balance equation [] [] [] | Reference to MetaCycID 6.3.5.7-RXN +s_3756[m] C20H29N7O12PR C5H10N2O2R 1 [] MNXM89810 r_4155 [] [] s_3756[m]: changed C20H29N7O12PR to C5H10N2O2R to match s_0747[c] with same metName but different compartment [] [] [] | Reference to MetaCycID 6.3.5.7-RXN +s_3808[m] R RH -1 0 MNXM90667 r_4187 MNXR103208 O1H-1 "| tRNA(Pro) should be uncharged, with an additional H atom" [] [] [] | Reference to BioCycID PROLINE--TRNA-LIGASE-RXN +s_3809[m] C5H8NOR C5H9NOR 0 1 MNXM247 r_4187 MNXR103208 O1H-1 "| Pro-tRNA(Pro) should be charged (+1), with an additional H atom" [] [] [] | Reference to BioCycID PROLINE--TRNA-LIGASE-RXN +s_1582[c] R RH [] 0 MNXM89576 r_4218 [] [] s_1582[c]: changed metFormula R to RH to balance equation | changed metCharges [] to 0 to balance equation [] [] [] | Reference to MetaCycID RXN-19726 +s_3856[c] [] C2H5NOR 0 1 0 r_4218 [] [] s_3856[c]: changed metFormula 0 to C2H5NOR to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] | Reference to MetaCycID RXN-19726 +s_1612[c] R RH 0 [] MNXM90668 r_4219 [] O1 "| tRNA(Tyr) should be uncharged, with an additional H atom" [] [] [] | Reference to MetaCycID RXN-19727 +s_3857[c] C9H10NO3R C9H11NO2R 0 1 [] r_4219 [] O1 | Deduced with reference to s_1612[c] and s_3858[c] i.e. tRNA(Tyr) and D-tyrosine; reference to EC 3.1.1.96 found in model.rxnNames [] [] [] | Reference to MetaCycID RXN-19727 +s_3908[m] C14H17N3O15P2R2 C14H19N3O15P2R2 -2 0 MNXM201 r_4251 MNXR107177 H2 | reference to 19118367 - conjugate acid of CDP-diacylglycerol (C14H17N3O15P2R2) more likely to be prevalent in neutral/acidic conditions in mitochondria | metFormula in MNX database (C14H17N3O15P2R2) with metCharge -2 is a conjugate base of CDP-diacylglycerol (C14H19N3O15P2R2) [] [] [] +s_3932[er] C50H66N4O29 C50H82N4O37 0 [] MNXM9328 r_4271 MNXR109973 H-1R1 s_3932[er]: changed C50H66N4O29 to C50H82N4O37 to balance equation | based on other metFormulas in r_4271 to determine glycan G00012 formula [] [] [] +s_3943[p] C10H14N5O8P C10H12N5O8P -2 [] MNXM2497 r_4279 MNXR113234 H4 s_3943[p]: changed C10H14N5O8P to C10H12N5O8P to balance equation [] [] [] [] +s_3942[p] C10H16N5O14P3 C10H12N5O14P3 -4 [] MNXM4425 r_4279; r_4253; r_4320; r_4321 MNXR113234 H4 s_3942[p]: changed C10H16N5O14P3 to C10H12N5O14P3 to balance equation [] [] [] [] +s_0412[c] C6H14NO8P C6H13NO8P 0 -1 MNXM162238 r_4286 MNXR100613 H-2 s_0412[c]: changed metFormula C6H14NO8P to C6H13NO8P to balance equation | changed metCharges 0 to -1 to balance equation [] [] [] [] +s_3953[c] C6H13NO5 C6H14NO5 0 1 MNXM533 r_4286 MNXR100613 H-2 s_3953[c]: changed metFormula C6H13NO5 to C6H14NO5 to balance equation | changed metCharges 0 to 1 to balance equation [] [] [] [] +s_3964[c] C7H16NO2 C7H15NO2 1 0 MNXM626 r_4297 MNXR108074 H-1 s_3964[c]: changed metFormula C7H16NO2 to C7H15NO2 to balance equation | changed metCharges 1 to 0 to balance equation | based on metFormula in MNXM626 [] [] [] +s_3968[c] C5H6N2O2 C5H5N2O2 0 -1 MNXM1330 r_4299 MNXR95745 H-1 s_3968[c]: changed metFormula C5H6N2O2 to C5H5N2O2 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM1330 [] [] [] +s_3972[c] C10H9NO3 C10H8NO3 0 -1 MNXM1961 r_4301 MNXR109205 H-1 s_3972[c]: changed metFormula C10H9NO3 to C10H8NO3 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM1961 [] [] [] +s_3980[c] C2H3ClO2 C2H2ClO2 0 -1 MNXM1468 r_4305 MNXR109457 H-1 s_3980[c]: changed metFormula C2H3ClO2 to C2H2ClO2 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM1468 [] [] [] +s_3982[c] C10H14O2 C10H13O2 0 -1 MNXM2414 r_4306 MNXR110183 H-1 s_3982[c]: changed metFormula C10H14O2 to C10H13O2 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM2414 [] [] [] +s_3984[c] C15H24O2 C15H23O2 0 -1 MNXM3989 r_4307 MNXR111724 H-1 s_3984[c]: changed metFormula C15H24O2 to C15H23O2 to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM3989 [] [] [] +s_4012[m] CHNS CNS 0 -1 MNXM762 r_4326 MNXR138187 H-1 s_4012[m]: changed metFormula CHNS to CNS to balance equation | changed metCharges 0 to -1 to balance equation | based on metFormula in MNXM762 [] [] [] +% +#for modification of H+/H2O/other met coefficient to balance equation "#Note: some modifications of H+/H2O may not directly lead to elemental balance e.g. model.S(601, 63), as there may be changes in metFormula for the same reaction" +#model.mets model.rxns current_coef new_coef elementdiff Notes refNotes +s_0795[er] r_0041 -2 -1 H1 "for model.mets: s_0795[er], model.rxns: r_0041, change model.S coefficient from -2 to -1 to balance equation" [] +s_0794[c] r_0045 0 1 H1 "for model.mets: s_0794[c], model.rxns: r_0045, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_0058 1 0 H-1 "for model.mets: s_0794[c], model.rxns: r_0058, change model.S coefficient from 1 to 0 to balance equation" [] +s_0794[c] r_0073 2 1 H-1 "for model.mets: s_0794[c], model.rxns: r_0073, change model.S coefficient from 2 to 1 to balance equation" [] +s_0794[c] r_0074 -2 -1 O-1H-14 "for model.mets: s_0794[c], model.rxns: r_0074, change model.S coefficient from -2 to -1 to balance equation" [] +s_0803[c] r_0074 1 0 O-1H-14 "for model.mets: s_0803[c], model.rxns: r_0074, change model.S coefficient from 1 to 0 to balance equation" [] +s_0794[c] r_0080 -2 -1 H1 "for model.mets: s_0794[c], model.rxns: r_0080, change model.S coefficient from -2 to -1 to balance equation" [] +s_0794[c] r_0082 2 1 H-1 "for model.mets: s_0794[c], model.rxns: r_0082, change model.S coefficient from 2 to 1 to balance equation" [] +s_0794[c] r_0083 -1 0 H1 "for model.mets: s_0794[c], model.rxns: r_0083, change model.S coefficient from -1 to 0 to balance equation" [] +s_0794[c] r_0092 2 1 H-1 "for model.mets: s_0794[c], model.rxns: r_0092, change model.S coefficient from 2 to 1 to balance equation" [] +s_0794[c] r_0093 -2 -1 O-1H-14 "for model.mets: s_0794[c], model.rxns: r_0093, change model.S coefficient from -2 to -1 to balance equation" [] +s_0803[c] r_0093 1 0 O-1H-14 "for model.mets: s_0803[c], model.rxns: r_0093, change model.S coefficient from 1 to 0 to balance equation" [] +s_0794[c] r_0094 4 -1 H-5 "for model.mets: s_0794[c], model.rxns: r_0094, change model.S coefficient from 4 to -1 to balance equation" [] +s_0794[c] r_0155 -1 1 H2 "for model.mets: s_0794[c], model.rxns: r_0155, change model.S coefficient from -1 to 1 to balance equation" [] +s_0797[g] r_0192 1 -1 H-2 "for model.mets: s_0797[g], model.rxns: r_0192, change model.S coefficient from 1 to -1 to balance equation" [] +s_0794[c] r_0228 0 1 H1 "for model.mets: s_0794[c], model.rxns: r_0228, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_0234 1 0 C1O-1H2 "for model.mets: s_0794[c], model.rxns: r_0234, change model.S coefficient from 1 to 0 to balance equation" | based on BioCyc ID: RXN66-318 +s_0794[c] r_0235 1 0 H-1 "for model.mets: s_0794[c], model.rxns: r_0235, change model.S coefficient from 1 to 0 to balance equation" [] +s_0794[c] r_0240 -1 0 C-1O1H-2 "for model.mets: s_0794[c], model.rxns: r_0240, change model.S coefficient from -1 to 0 to balance equation" | based on BioCyc ID: RXN66-313 +s_0794[c] r_0241 -3 -2 H1 "for model.mets: s_0794[c], model.rxns: r_0241, change model.S coefficient from -3 to -2 to balance equation" | based on current model.rxnMetaNetX MNXR111130 +s_0794[c] r_0249 2 0 H-2 "for model.mets: s_0794[c], model.rxns: r_0249, change model.S coefficient from 2 to 0 to balance equation" [] +s_0794[c] r_0312 1 0 H-1 "for model.mets: s_0794[c], model.rxns: r_0312, change model.S coefficient from 1 to 0 to balance equation" [] +s_0794[c] r_0319 0 1 H1 "for model.mets: s_0794[c], model.rxns: r_0319, change model.S coefficient from 0 to 1 to balance equation" [] +s_0804[er] r_0340 0 1 O1H2 "for model.mets: s_0804[er], model.rxns: r_0340, change model.S coefficient from 0 to 1 to balance equation" [] +s_0804[er] r_0341 0 1 O1H2 "for model.mets: s_0804[er], model.rxns: r_0341, change model.S coefficient from 0 to 1 to balance equation" [] +s_0804[er] r_0342 0 -1 O-1H-2 "for model.mets: s_0804[er], model.rxns: r_0342, change model.S coefficient from 0 to -1 to balance equation" [] +s_0804[er] r_0343 0 -1 O-1H-2 "for model.mets: s_0804[er], model.rxns: r_0343, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_0357 6 3 H-3 "for model.mets: s_0794[c], model.rxns: r_0357, change model.S coefficient from 6 to 3 to balance equation" [] +s_0794[c] r_0358 -5 -2 H3 "for model.mets: s_0794[c], model.rxns: r_0358, change model.S coefficient from -5 to -2 to balance equation" [] +s_0794[c] r_0360 1 -1 H-1R1 "for model.mets: s_0794[c], model.rxns: r_0360, change model.S coefficient from 1 to -1 to balance equation" [] +s_0794[c] r_0361 0 1 H-1 "for model.mets: s_0794[c], model.rxns: r_0361, change model.S coefficient from 0 to 1 to balance equation" [] +s_0795[er] r_0362 1 0 O-1H-3 "for model.mets: s_0795[er], model.rxns: r_0362, change model.S coefficient from 1 to 0 to balance equation" [] +s_0794[c] r_0441 -1 -2 H-1 "for model.mets: s_0794[c], model.rxns: r_0441, change model.S coefficient from -1 to -2 to balance equation" [] +s_0794[c] r_0442 -1 -2 H-1 "for model.mets: s_0794[c], model.rxns: r_0442, change model.S coefficient from -1 to -2 to balance equation" [] +s_0799[m] r_0454 0 1 H1 "for model.mets: s_0799[m], model.rxns: r_0454, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_0455 0 1 H1 "for model.mets: s_0794[c], model.rxns: r_0455, change model.S coefficient from 0 to 1 to balance equation" [] +s_0799[m] r_0490 0 -1 H-1 "for model.mets: s_0799[m], model.rxns: r_0490, change model.S coefficient from 0 to -1 to balance equation" [] +s_0799[m] r_0506 -1 0 C4N2O3H6R1 "for model.mets: s_0799[m], model.rxns: r_0506, change model.S coefficient from -1 to 0 to balance equation" [] +s_0799[m] r_0507 0 -1 H-1 "for model.mets: s_0799[m], model.rxns: r_0507, change model.S coefficient from 0 to -1 to balance equation" [] +s_0803[c] r_0510 -1 0 O1H2 "for model.mets: s_0803[c], model.rxns: r_0510, change model.S coefficient from -1 to 0 to balance equation" | based on current model.rxnMetaNetX MNXR143136 +s_0799[m] r_0545 1 0 H-1 "for model.mets: s_0799[m], model.rxns: r_0545, change model.S coefficient from 1 to 0 to balance equation" [] +s_0794[c] r_0550 0 -1 H-1R-2 "for model.mets: s_0794[c], model.rxns: r_0550, change model.S coefficient from 0 to -1 to balance equation" [] +s_0799[m] r_0551 0 -1 H-1R-2 "for model.mets: s_0799[m], model.rxns: r_0551, change model.S coefficient from 0 to -1 to balance equation" [] +s_0801[p] r_0552 0 -1 H-1R-2 "for model.mets: s_0801[p], model.rxns: r_0552, change model.S coefficient from 0 to -1 to balance equation" [] +s_0800[n] r_0571 -1 1 H2 "for model.mets: s_0800[n], model.rxns: r_0571, change model.S coefficient from -1 to 1 to balance equation" [] +s_0800[n] r_0572 -1 1 H2 "for model.mets: s_0800[n], model.rxns: r_0572, change model.S coefficient from -1 to 1 to balance equation" [] +s_0800[n] r_0573 -1 1 H2 "for model.mets: s_0800[n], model.rxns: r_0573, change model.S coefficient from -1 to 1 to balance equation" [] +s_0800[n] r_0574 -1 1 H2 "for model.mets: s_0800[n], model.rxns: r_0574, change model.S coefficient from -1 to 1 to balance equation" [] +s_0800[n] r_0575 -1 1 H2 "for model.mets: s_0800[n], model.rxns: r_0575, change model.S coefficient from -1 to 1 to balance equation" [] +s_0799[m] r_0616 0 2 H2 "for model.mets: s_0799[m], model.rxns: r_0616, change model.S coefficient from 0 to 2 to balance equation" [] +s_0799[m] r_0617 0 2 H2 "for model.mets: s_0799[m], model.rxns: r_0617, change model.S coefficient from 0 to 2 to balance equation" [] +s_0799[m] r_0618 0 2 H2 "for model.mets: s_0799[m], model.rxns: r_0618, change model.S coefficient from 0 to 2 to balance equation" [] +s_0799[m] r_0619 0 2 H2 "for model.mets: s_0799[m], model.rxns: r_0619, change model.S coefficient from 0 to 2 to balance equation" [] +s_0799[m] r_0620 0 2 H2 "for model.mets: s_0799[m], model.rxns: r_0620, change model.S coefficient from 0 to 2 to balance equation" [] +s_0799[m] r_0621 0 2 H2 "for model.mets: s_0799[m], model.rxns: r_0621, change model.S coefficient from 0 to 2 to balance equation" [] +s_0799[m] r_0622 0 2 H2 "for model.mets: s_0799[m], model.rxns: r_0622, change model.S coefficient from 0 to 2 to balance equation" [] +s_0799[m] r_0623 0 2 H2 "for model.mets: s_0799[m], model.rxns: r_0623, change model.S coefficient from 0 to 2 to balance equation" [] +s_0799[m] r_0624 0 2 H2 "for model.mets: s_0799[m], model.rxns: r_0624, change model.S coefficient from 0 to 2 to balance equation" [] +s_0799[m] r_0625 0 2 H2 "for model.mets: s_0799[m], model.rxns: r_0625, change model.S coefficient from 0 to 2 to balance equation" [] +s_0795[er] r_0646 0 2 H2 "for model.mets: s_0795[er], model.rxns: r_0646, change model.S coefficient from 0 to 2 to balance equation" [] +s_0795[er] r_0647 0 2 H2 "for model.mets: s_0795[er], model.rxns: r_0647, change model.S coefficient from 0 to 2 to balance equation" [] +s_0795[er] r_0648 0 2 H2 "for model.mets: s_0795[er], model.rxns: r_0648, change model.S coefficient from 0 to 2 to balance equation" [] +s_0795[er] r_0649 0 2 H2 "for model.mets: s_0795[er], model.rxns: r_0649, change model.S coefficient from 0 to 2 to balance equation" [] +s_0795[er] r_0650 0 2 H2 "for model.mets: s_0795[er], model.rxns: r_0650, change model.S coefficient from 0 to 2 to balance equation" [] +s_0795[er] r_0651 0 2 H2 "for model.mets: s_0795[er], model.rxns: r_0651, change model.S coefficient from 0 to 2 to balance equation" [] +s_0795[er] r_0652 0 2 H2 "for model.mets: s_0795[er], model.rxns: r_0652, change model.S coefficient from 0 to 2 to balance equation" [] +s_0795[er] r_0653 0 2 H2 "for model.mets: s_0795[er], model.rxns: r_0653, change model.S coefficient from 0 to 2 to balance equation" [] +s_0795[er] r_0654 0 2 H2 "for model.mets: s_0795[er], model.rxns: r_0654, change model.S coefficient from 0 to 2 to balance equation" [] +s_0795[er] r_0655 0 2 H2 "for model.mets: s_0795[er], model.rxns: r_0655, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_0727 1 0 H-1 "for model.mets: s_0794[c], model.rxns: r_0727, change model.S coefficient from 1 to 0 to balance equation" [] +s_0797[g] r_0747 0 1 H1 "for model.mets: s_0797[g], model.rxns: r_0747, change model.S coefficient from 0 to 1 to balance equation" [] +s_0797[g] r_0748 0 1 H2 "for model.mets: s_0797[g], model.rxns: r_0748, change model.S coefficient from 0 to 1 to balance equation" [] +s_0797[g] r_0749 0 1 H1 "for model.mets: s_0797[g], model.rxns: r_0749, change model.S coefficient from 0 to 1 to balance equation" [] +s_0797[g] r_0750 0 1 H1 "for model.mets: s_0797[g], model.rxns: r_0750, change model.S coefficient from 0 to 1 to balance equation" [] +s_0797[g] r_0751 0 1 H1 "for model.mets: s_0797[g], model.rxns: r_0751, change model.S coefficient from 0 to 1 to balance equation" [] +s_0797[g] r_0752 0 1 H1 "for model.mets: s_0797[g], model.rxns: r_0752, change model.S coefficient from 0 to 1 to balance equation" [] +s_0797[g] r_0753 0 1 H1 "for model.mets: s_0797[g], model.rxns: r_0753, change model.S coefficient from 0 to 1 to balance equation" [] +s_0797[g] r_0754 0 1 H1 "for model.mets: s_0797[g], model.rxns: r_0754, change model.S coefficient from 0 to 1 to balance equation" [] +s_0797[g] r_0755 0 1 H1 "for model.mets: s_0797[g], model.rxns: r_0755, change model.S coefficient from 0 to 1 to balance equation" [] +s_0797[g] r_0756 0 1 H1 "for model.mets: s_0797[g], model.rxns: r_0756, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_0813 1 0 H-1 "for model.mets: s_0794[c], model.rxns: r_0813, change model.S coefficient from 1 to 0 to balance equation" [] +s_0794[c] r_0855 2 1 H-1 "for model.mets: s_0794[c], model.rxns: r_0855, change model.S coefficient from 2 to 1 to balance equation" [] +s_0794[c] r_0883 2 1 H-2R-2 "for model.mets: s_0794[c], model.rxns: r_0883, change model.S coefficient from 2 to 1 to balance equation" [] +s_0794[c] r_0908 1 2 H1 "for model.mets: s_0794[c], model.rxns: r_0908, change model.S coefficient from 1 to 2 to balance equation" [] +s_0394[c] r_0911 1 0 H2 "for model.mets: s_0394[c], model.rxns: r_0911, change model.S coefficient from 1 to 0 to balance equation" [] +s_0434[c] r_0911 -1 0 H2 "for model.mets: s_0434[c], model.rxns: r_0911, change model.S coefficient from -1 to 0 to balance equation" [] +s_0803[c] r_0911 -1 0 H2 "for model.mets: s_0803[c], model.rxns: r_0911, change model.S coefficient from -1 to 0 to balance equation" [] +s_1322[c] r_0911 1 0 H2 "for model.mets: s_1322[c], model.rxns: r_0911, change model.S coefficient from 1 to 0 to balance equation" [] +s_0804[er] r_0919 0 1 O1H2 "for model.mets: s_0804[er], model.rxns: r_0919, change model.S coefficient from 0 to 1 to balance equation" [] +s_0804[er] r_0920 0 1 O1H1 "for model.mets: s_0804[er], model.rxns: r_0920, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_0941 1 0 O1H-1 "for model.mets: s_0794[c], model.rxns: r_0941, change model.S coefficient from 1 to 0 to balance equation" [] +s_0794[c] r_0967 0 1 H1 "for model.mets: s_0794[c], model.rxns: r_0967, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_0968 0 -1 H-1 "for model.mets: s_0794[c], model.rxns: r_0968, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_0970 0 -1 N-1H-1R-2 "for model.mets: s_0794[c], model.rxns: r_0970, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_0971 0 -1 N-1H-1R-2 "for model.mets: s_0794[c], model.rxns: r_0971, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_0972 0 -1 N-1H-1R-2 "for model.mets: s_0794[c], model.rxns: r_0972, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_0973 0 -1 N-1H-1R-2 "for model.mets: s_0794[c], model.rxns: r_0973, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_0974 0 -1 N-1H-1R-2 "for model.mets: s_0794[c], model.rxns: r_0974, change model.S coefficient from 0 to -1 to balance equation" [] +s_0800[n] r_0975 0 -1 N-1H-1R-2 "for model.mets: s_0800[n], model.rxns: r_0975, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_0976 0 -1 N-1H-1R-2 "for model.mets: s_0794[c], model.rxns: r_0976, change model.S coefficient from 0 to -1 to balance equation" [] +s_0800[n] r_0977 0 -1 N-1H-1R-2 "for model.mets: s_0800[n], model.rxns: r_0977, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_0978 0 -1 N-1H-1R-2 "for model.mets: s_0794[c], model.rxns: r_0978, change model.S coefficient from 0 to -1 to balance equation" [] +s_0800[n] r_0979 0 -1 N-1H-1R-2 "for model.mets: s_0800[n], model.rxns: r_0979, change model.S coefficient from 0 to -1 to balance equation" [] +s_0795[er] r_0993 0 -1 H-1 "for model.mets: s_0795[er], model.rxns: r_0993, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_0998 1 2 H1 "for model.mets: s_0794[c], model.rxns: r_0998, change model.S coefficient from 1 to 2 to balance equation" [] +s_0794[c] r_0999 3 2 H-1 "for model.mets: s_0794[c], model.rxns: r_0999, change model.S coefficient from 3 to 2 to balance equation" [] +s_0794[c] r_1000 0 1 H1 "for model.mets: s_0794[c], model.rxns: r_1000, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_1027 -5 -4 H1 "for model.mets: s_0794[c], model.rxns: r_1027, change model.S coefficient from -5 to -4 to balance equation" [] +s_0800[n] r_1037 0 -1 H-1R-2 "for model.mets: s_0800[n], model.rxns: r_1037, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_1038 -1 0 N1H1R2 "for model.mets: s_0794[c], model.rxns: r_1038, change model.S coefficient from -1 to 0 to balance equation" [] +s_0799[m] r_1039 -1 0 N1H1R2 "for model.mets: s_0799[m], model.rxns: r_1039, change model.S coefficient from -1 to 0 to balance equation" [] +s_0794[c] r_1603 -2 1 H1 "for model.mets: s_0794[c], model.rxns: r_1603, change model.S coefficient from -2 to 1 to balance equation" [] +s_0803[c] r_2112 0 1 O1H1 "for model.mets: s_0803[c], model.rxns: r_2112, change model.S coefficient from 0 to 1 to balance equation" [] +s_1207[c] r_2113 0 1 O1H-1 "for model.mets: s_1207[c], model.rxns: r_2113, change model.S coefficient from 0 to 1 to balance equation" "| General reduced acceptor listed in MNXR108341 and R03687, most common reduced acceptor NADPH to be used until further information is available" +s_1212[c] r_2113 0 -1 O1H-1 "for model.mets: s_1212[c], model.rxns: r_2113, change model.S coefficient from 0 to -1 to balance equation" "| General acceptor listed in MNXR108341 and R03687, most common acceptor NADP(+) to be used until further information is available" +s_0803[c] r_2113 0 1 O1H-1 "for model.mets: s_0803[c], model.rxns: r_2113, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_2113 0 -2 O1H-1 "for model.mets: s_0794[c], model.rxns: r_2113, change model.S coefficient from 0 to -2 to balance equation" [] +s_0794[c] r_2114 0 1 H-1 "for model.mets: s_0794[c], model.rxns: r_2114, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_2116 1 2 H1 "for model.mets: s_0794[c], model.rxns: r_2116, change model.S coefficient from 1 to 2 to balance equation" [] +s_0803[c] r_2126 0 -1 O-1H-2 "for model.mets: s_0803[c], model.rxns: r_2126, change model.S coefficient from 0 to -1 to balance equation" | Hydrolase reaction +s_0801[p] r_2232 1 5 H4 "for model.mets: s_0801[p], model.rxns: r_2232, change model.S coefficient from 1 to 5 to balance equation" [] +s_0801[p] r_2233 1 5 H4 "for model.mets: s_0801[p], model.rxns: r_2233, change model.S coefficient from 1 to 5 to balance equation" [] +s_0801[p] r_2242 0 -4 H4 "for model.mets: s_0801[p], model.rxns: r_2242, change model.S coefficient from 0 to -4 to balance equation" [] +s_0801[p] r_2254 0 4 H4 "for model.mets: s_0801[p], model.rxns: r_2254, change model.S coefficient from 0 to 4 to balance equation" [] +s_0801[p] r_2256 0 -4 H-4 "for model.mets: s_0801[p], model.rxns: r_2256, change model.S coefficient from 0 to -4 to balance equation" [] +s_0801[p] r_2263 0 -4 H-4 "for model.mets: s_0801[p], model.rxns: r_2263, change model.S coefficient from 0 to -4 to balance equation" [] +s_0801[p] r_2295 0 4 H4 "for model.mets: s_0801[p], model.rxns: r_2295, change model.S coefficient from 0 to 4 to balance equation" [] +s_0801[p] r_2297 0 4 H4 "for model.mets: s_0801[p], model.rxns: r_2297, change model.S coefficient from 0 to 4 to balance equation" [] +s_0801[p] r_2298 0 4 H4 "for model.mets: s_0801[p], model.rxns: r_2298, change model.S coefficient from 0 to 4 to balance equation" [] +s_0801[p] r_2300 0 4 H4 "for model.mets: s_0801[p], model.rxns: r_2300, change model.S coefficient from 0 to 4 to balance equation" [] +s_2783[erm] r_2308 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2308, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2309 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2309, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2310 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2310, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2311 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2311, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2312 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2312, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2313 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2313, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2314 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2314, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2315 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2315, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2316 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2316, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2317 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2317, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2318 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2318, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2319 0 -2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2319, change model.S coefficient from 0 to -2 to balance equation" [] +s_0798[lp] r_2320 0 -2 H-2 "for model.mets: s_0798[lp], model.rxns: r_2320, change model.S coefficient from 0 to -2 to balance equation" [] +s_0798[lp] r_2321 0 -2 H-2 "for model.mets: s_0798[lp], model.rxns: r_2321, change model.S coefficient from 0 to -2 to balance equation" [] +s_0798[lp] r_2322 0 -2 H-2 "for model.mets: s_0798[lp], model.rxns: r_2322, change model.S coefficient from 0 to -2 to balance equation" [] +s_0798[lp] r_2323 0 -2 H-2 "for model.mets: s_0798[lp], model.rxns: r_2323, change model.S coefficient from 0 to -2 to balance equation" [] +s_2783[erm] r_2344 0 2 H-2 "for model.mets: s_2783[erm], model.rxns: r_2344, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_2783[erm] r_2345 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_2345, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_2783[erm] r_2346 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_2346, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_2783[erm] r_2347 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_2347, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_2783[erm] r_2348 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_2348, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_2783[erm] r_2349 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_2349, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_2783[erm] r_2350 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_2350, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_2783[erm] r_2351 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_2351, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3164[vm] r_2352 0 2 H-2 "for model.mets: s_3164[vm], model.rxns: r_2352, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3164[vm] r_2353 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_2353, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3164[vm] r_2354 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_2354, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3164[vm] r_2355 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_2355, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3164[vm] r_2356 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_2356, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3164[vm] r_2357 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_2357, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3164[vm] r_2358 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_2358, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3164[vm] r_2359 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_2359, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3146[gm] r_2360 0 2 H-2 "for model.mets: s_3146[gm], model.rxns: r_2360, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3146[gm] r_2361 0 2 H-2 "for model.mets: s_3146[gm], model.rxns: r_2361, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3146[gm] r_2362 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_2362, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3146[gm] r_2363 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_2363, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3146[gm] r_2364 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_2364, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3146[gm] r_2365 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_2365, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3146[gm] r_2366 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_2366, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_3146[gm] r_2367 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_2367, change model.S coefficient from 0 to 2 to balance equation" https://doi.org/10.1038/s41598-018-30367-z +s_2783[erm] r_2446 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2446, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2447 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2447, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2448 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2448, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2449 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2449, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2450 1 2 H-1 "for model.mets: s_2783[erm], model.rxns: r_2450, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2451 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2451, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2452 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2452, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2453 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2453, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2454 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2454, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2455 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2455, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2456 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2456, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2457 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2457, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2458 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2458, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2459 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2459, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2460 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2460, change model.S coefficient from 1 to 2 to balance equation" [] +s_2783[erm] r_2461 1 2 H1 "for model.mets: s_2783[erm], model.rxns: r_2461, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2464 -1 0 H1 "for model.mets: s_3094[mm], model.rxns: r_2464, change model.S coefficient from -1 to 0 to balance equation" [] +s_3094[mm] r_2465 -1 0 H1 "for model.mets: s_3094[mm], model.rxns: r_2465, change model.S coefficient from -1 to 0 to balance equation" [] +s_3094[mm] r_2466 -1 0 H1 "for model.mets: s_3094[mm], model.rxns: r_2466, change model.S coefficient from -1 to 0 to balance equation" [] +s_3094[mm] r_2467 -1 0 H1 "for model.mets: s_3094[mm], model.rxns: r_2467, change model.S coefficient from -1 to 0 to balance equation" [] +s_3094[mm] r_2468 -1 0 H1 "for model.mets: s_3094[mm], model.rxns: r_2468, change model.S coefficient from -1 to 0 to balance equation" [] +s_3094[mm] r_2469 -1 0 H1 "for model.mets: s_3094[mm], model.rxns: r_2469, change model.S coefficient from -1 to 0 to balance equation" [] +s_3094[mm] r_2470 -1 0 H1 "for model.mets: s_3094[mm], model.rxns: r_2470, change model.S coefficient from -1 to 0 to balance equation" [] +s_3094[mm] r_2471 -1 0 H1 "for model.mets: s_3094[mm], model.rxns: r_2471, change model.S coefficient from -1 to 0 to balance equation" [] +s_3146[gm] r_2472 -1 0 H1 "for model.mets: s_3146[gm], model.rxns: r_2472, change model.S coefficient from -1 to 0 to balance equation" [] +s_3146[gm] r_2473 -1 0 H1 "for model.mets: s_3146[gm], model.rxns: r_2473, change model.S coefficient from -1 to 0 to balance equation" [] +s_3146[gm] r_2474 -1 0 H1 "for model.mets: s_3146[gm], model.rxns: r_2474, change model.S coefficient from -1 to 0 to balance equation" [] +s_3146[gm] r_2475 -1 0 H1 "for model.mets: s_3146[gm], model.rxns: r_2475, change model.S coefficient from -1 to 0 to balance equation" [] +s_3146[gm] r_2476 -1 0 H1 "for model.mets: s_3146[gm], model.rxns: r_2476, change model.S coefficient from -1 to 0 to balance equation" [] +s_3146[gm] r_2477 -1 0 H1 "for model.mets: s_3146[gm], model.rxns: r_2477, change model.S coefficient from -1 to 0 to balance equation" [] +s_3146[gm] r_2478 -1 0 H1 "for model.mets: s_3146[gm], model.rxns: r_2478, change model.S coefficient from -1 to 0 to balance equation" [] +s_3146[gm] r_2479 -1 0 H1 "for model.mets: s_3146[gm], model.rxns: r_2479, change model.S coefficient from -1 to 0 to balance equation" [] +s_3164[vm] r_2480 -1 0 H1 "for model.mets: s_3164[vm], model.rxns: r_2480, change model.S coefficient from -1 to 0 to balance equation" [] +s_3164[vm] r_2481 -1 0 H1 "for model.mets: s_3164[vm], model.rxns: r_2481, change model.S coefficient from -1 to 0 to balance equation" [] +s_3164[vm] r_2482 -1 0 H1 "for model.mets: s_3164[vm], model.rxns: r_2482, change model.S coefficient from -1 to 0 to balance equation" [] +s_3164[vm] r_2483 -1 0 H1 "for model.mets: s_3164[vm], model.rxns: r_2483, change model.S coefficient from -1 to 0 to balance equation" [] +s_3164[vm] r_2484 -1 0 H1 "for model.mets: s_3164[vm], model.rxns: r_2484, change model.S coefficient from -1 to 0 to balance equation" [] +s_3164[vm] r_2485 -1 0 H1 "for model.mets: s_3164[vm], model.rxns: r_2485, change model.S coefficient from -1 to 0 to balance equation" [] +s_3164[vm] r_2486 -1 0 H1 "for model.mets: s_3164[vm], model.rxns: r_2486, change model.S coefficient from -1 to 0 to balance equation" [] +s_3164[vm] r_2487 -1 0 H1 "for model.mets: s_3164[vm], model.rxns: r_2487, change model.S coefficient from -1 to 0 to balance equation" [] +s_2783[erm] r_2512 1 -1 H-2 "for model.mets: s_2783[erm], model.rxns: r_2512, change model.S coefficient from 1 to -1 to balance equation" [] +s_2783[erm] r_2513 1 -1 H-2 "for model.mets: s_2783[erm], model.rxns: r_2513, change model.S coefficient from 1 to -1 to balance equation" [] +s_2783[erm] r_2514 1 -1 H-2 "for model.mets: s_2783[erm], model.rxns: r_2514, change model.S coefficient from 1 to -1 to balance equation" [] +s_2783[erm] r_2515 1 -1 H-2 "for model.mets: s_2783[erm], model.rxns: r_2515, change model.S coefficient from 1 to -1 to balance equation" [] +s_2783[erm] r_2516 1 -1 H-2 "for model.mets: s_2783[erm], model.rxns: r_2516, change model.S coefficient from 1 to -1 to balance equation" [] +s_2783[erm] r_2517 1 -1 H-2 "for model.mets: s_2783[erm], model.rxns: r_2517, change model.S coefficient from 1 to -1 to balance equation" [] +s_2783[erm] r_2518 1 -1 H-2 "for model.mets: s_2783[erm], model.rxns: r_2518, change model.S coefficient from 1 to -1 to balance equation" [] +s_2783[erm] r_2519 1 -1 H-2 "for model.mets: s_2783[erm], model.rxns: r_2519, change model.S coefficient from 1 to -1 to balance equation" [] +s_3094[mm] r_2536 1 0 C-2H-1 "for model.mets: s_3094[mm], model.rxns: r_2536, change model.S coefficient from 1 to 0 to balance equation" [] +s_3094[mm] r_2537 1 0 C-2H-1 "for model.mets: s_3094[mm], model.rxns: r_2537, change model.S coefficient from 1 to 0 to balance equation" [] +s_3094[mm] r_2538 1 0 C-2H1 "for model.mets: s_3094[mm], model.rxns: r_2538, change model.S coefficient from 1 to 0 to balance equation" [] +s_3094[mm] r_2539 1 0 C-2H1 "for model.mets: s_3094[mm], model.rxns: r_2539, change model.S coefficient from 1 to 0 to balance equation" [] +s_3094[mm] r_2540 1 0 C-2H-1 "for model.mets: s_3094[mm], model.rxns: r_2540, change model.S coefficient from 1 to 0 to balance equation" [] +s_3094[mm] r_2541 1 0 C-2H1 "for model.mets: s_3094[mm], model.rxns: r_2541, change model.S coefficient from 1 to 0 to balance equation" [] +s_3094[mm] r_2542 0 2 C2H2 "for model.mets: s_3094[mm], model.rxns: r_2542, change model.S coefficient from 0 to 2 to balance equation" [] +s_3094[mm] r_2543 0 2 C2H2 "for model.mets: s_3094[mm], model.rxns: r_2543, change model.S coefficient from 0 to 2 to balance equation" [] +s_3094[mm] r_2544 0 2 C2 "for model.mets: s_3094[mm], model.rxns: r_2544, change model.S coefficient from 0 to 2 to balance equation" [] +s_3094[mm] r_2545 0 2 C2 "for model.mets: s_3094[mm], model.rxns: r_2545, change model.S coefficient from 0 to 2 to balance equation" [] +s_3094[mm] r_2546 0 2 C2 "for model.mets: s_3094[mm], model.rxns: r_2546, change model.S coefficient from 0 to 2 to balance equation" [] +s_3094[mm] r_2547 0 2 C2 "for model.mets: s_3094[mm], model.rxns: r_2547, change model.S coefficient from 0 to 2 to balance equation" [] +s_3094[mm] r_2548 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2548, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2549 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2549, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2550 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2550, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2551 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2551, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2552 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2552, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2553 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2553, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2554 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2554, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2555 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2555, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2556 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2556, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2557 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2557, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2558 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2558, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2559 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2559, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2560 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2560, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2561 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2561, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2562 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2562, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2563 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2563, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2564 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2564, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2565 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2565, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2566 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2566, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2567 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2567, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2568 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2568, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2569 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2569, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2570 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2570, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2571 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2571, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2572 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2572, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2573 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2573, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2574 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2574, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2575 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2575, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2576 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2576, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2577 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2577, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2578 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2578, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2579 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2579, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2580 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2580, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2581 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2581, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2582 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2582, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_2583 1 2 H-1 "for model.mets: s_3094[mm], model.rxns: r_2583, change model.S coefficient from 1 to 2 to balance equation" [] +s_0793[ce] r_2820 1 -1 H-3 "for model.mets: s_0793[ce], model.rxns: r_2820, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2821 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2821, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2822 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2822, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2823 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2823, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2824 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2824, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2825 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2825, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2826 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2826, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2827 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2827, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2828 1 -1 H-3 "for model.mets: s_3164[vm], model.rxns: r_2828, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2829 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2829, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2830 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2830, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2831 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2831, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2832 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2832, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2833 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2833, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2834 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2834, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2835 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2835, change model.S coefficient from 1 to -1 to balance equation" [] +s_3146[gm] r_2836 1 -1 H-3 "for model.mets: s_3146[gm], model.rxns: r_2836, change model.S coefficient from 1 to -1 to balance equation" [] +s_3146[gm] r_2837 1 -1 H-2 "for model.mets: s_3146[gm], model.rxns: r_2837, change model.S coefficient from 1 to -1 to balance equation" [] +s_3146[gm] r_2838 1 -1 H-2 "for model.mets: s_3146[gm], model.rxns: r_2838, change model.S coefficient from 1 to -1 to balance equation" [] +s_3146[gm] r_2839 1 -1 H-2 "for model.mets: s_3146[gm], model.rxns: r_2839, change model.S coefficient from 1 to -1 to balance equation" [] +s_3146[gm] r_2840 1 -1 H-2 "for model.mets: s_3146[gm], model.rxns: r_2840, change model.S coefficient from 1 to -1 to balance equation" [] +s_3146[gm] r_2841 1 -1 H-2 "for model.mets: s_3146[gm], model.rxns: r_2841, change model.S coefficient from 1 to -1 to balance equation" [] +s_3146[gm] r_2842 1 -1 H-2 "for model.mets: s_3146[gm], model.rxns: r_2842, change model.S coefficient from 1 to -1 to balance equation" [] +s_3146[gm] r_2843 1 -1 H-2 "for model.mets: s_3146[gm], model.rxns: r_2843, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2844 1 -1 H-3 "for model.mets: s_0800[n], model.rxns: r_2844, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2845 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2845, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2846 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2846, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2847 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2847, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2848 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2848, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2849 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2849, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2850 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2850, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2851 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2851, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2852 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2852, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2853 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2853, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2854 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2854, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2855 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2855, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2856 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2856, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2857 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2857, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2858 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2858, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2859 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2859, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2860 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2860, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2861 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2861, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2862 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2862, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2863 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2863, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2864 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2864, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2865 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2865, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2866 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2866, change model.S coefficient from 1 to -1 to balance equation" [] +s_0800[n] r_2867 1 -1 H-2 "for model.mets: s_0800[n], model.rxns: r_2867, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2868 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2868, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2869 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2869, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2870 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2870, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2871 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2871, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2872 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2872, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2873 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2873, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2874 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2874, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_2875 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_2875, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2876 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2876, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2877 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2877, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2878 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2878, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2879 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2879, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2880 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2880, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2881 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2881, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2882 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2882, change model.S coefficient from 1 to -1 to balance equation" [] +s_3164[vm] r_2883 1 -1 H-2 "for model.mets: s_3164[vm], model.rxns: r_2883, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_3078 1 2 H1 "for model.mets: s_0793[ce], model.rxns: r_3078, change model.S coefficient from 1 to 2 to balance equation" [] +s_0793[ce] r_3079 1 2 H1 "for model.mets: s_0793[ce], model.rxns: r_3079, change model.S coefficient from 1 to 2 to balance equation" [] +s_0793[ce] r_3080 1 2 H1 "for model.mets: s_0793[ce], model.rxns: r_3080, change model.S coefficient from 1 to 2 to balance equation" [] +s_0793[ce] r_3081 1 2 H1 "for model.mets: s_0793[ce], model.rxns: r_3081, change model.S coefficient from 1 to 2 to balance equation" [] +s_0794[c] r_3082 1 6 H5 "for model.mets: s_0794[c], model.rxns: r_3082, change model.S coefficient from 1 to 6 to balance equation" [] +s_0794[c] r_3083 1 6 H5 "for model.mets: s_0794[c], model.rxns: r_3083, change model.S coefficient from 1 to 6 to balance equation" [] +s_0794[c] r_3084 1 6 H5 "for model.mets: s_0794[c], model.rxns: r_3084, change model.S coefficient from 1 to 6 to balance equation" [] +s_0794[c] r_3085 1 6 H5 "for model.mets: s_0794[c], model.rxns: r_3085, change model.S coefficient from 1 to 6 to balance equation" [] +s_0794[c] r_3086 1 6 H5 "for model.mets: s_0794[c], model.rxns: r_3086, change model.S coefficient from 1 to 6 to balance equation" [] +s_0794[c] r_3087 1 6 H5 "for model.mets: s_0794[c], model.rxns: r_3087, change model.S coefficient from 1 to 6 to balance equation" [] +s_0794[c] r_3088 1 6 H5 "for model.mets: s_0794[c], model.rxns: r_3088, change model.S coefficient from 1 to 6 to balance equation" [] +s_0794[c] r_3089 1 6 H5 "for model.mets: s_0794[c], model.rxns: r_3089, change model.S coefficient from 1 to 6 to balance equation" [] +s_0800[n] r_3090 1 6 H5 "for model.mets: s_0800[n], model.rxns: r_3090, change model.S coefficient from 1 to 6 to balance equation" [] +s_0800[n] r_3091 1 6 H5 "for model.mets: s_0800[n], model.rxns: r_3091, change model.S coefficient from 1 to 6 to balance equation" [] +s_0800[n] r_3092 1 6 H5 "for model.mets: s_0800[n], model.rxns: r_3092, change model.S coefficient from 1 to 6 to balance equation" [] +s_0800[n] r_3093 1 6 H5 "for model.mets: s_0800[n], model.rxns: r_3093, change model.S coefficient from 1 to 6 to balance equation" [] +s_0800[n] r_3094 1 6 H5 "for model.mets: s_0800[n], model.rxns: r_3094, change model.S coefficient from 1 to 6 to balance equation" [] +s_0800[n] r_3095 1 6 H5 "for model.mets: s_0800[n], model.rxns: r_3095, change model.S coefficient from 1 to 6 to balance equation" [] +s_0800[n] r_3096 1 6 H5 "for model.mets: s_0800[n], model.rxns: r_3096, change model.S coefficient from 1 to 6 to balance equation" [] +s_0800[n] r_3097 1 6 H5 "for model.mets: s_0800[n], model.rxns: r_3097, change model.S coefficient from 1 to 6 to balance equation" [] +s_3094[mm] r_3098 1 2 H1 "for model.mets: s_3094[mm], model.rxns: r_3098, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_3099 1 2 H1 "for model.mets: s_3094[mm], model.rxns: r_3099, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_3100 1 2 H1 "for model.mets: s_3094[mm], model.rxns: r_3100, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_3101 1 2 H1 "for model.mets: s_3094[mm], model.rxns: r_3101, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_3102 1 2 H1 "for model.mets: s_3094[mm], model.rxns: r_3102, change model.S coefficient from 1 to 2 to balance equation" [] +s_3094[mm] r_3103 1 2 H1 "for model.mets: s_3094[mm], model.rxns: r_3103, change model.S coefficient from 1 to 2 to balance equation" [] +s_0793[ce] r_3104 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_3104, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_3105 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_3105, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_3106 1 -1 O-1H-2 "for model.mets: s_0793[ce], model.rxns: r_3106, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_3107 1 -1 O-1H-2 "for model.mets: s_0793[ce], model.rxns: r_3107, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_3108 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_3108, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_3109 1 -1 H-2 "for model.mets: s_0793[ce], model.rxns: r_3109, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_3110 1 -1 O-1H-2 "for model.mets: s_0793[ce], model.rxns: r_3110, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_3111 1 -1 O-1H-2 "for model.mets: s_0793[ce], model.rxns: r_3111, change model.S coefficient from 1 to -1 to balance equation" [] +s_0793[ce] r_3112 0 2 H3 "for model.mets: s_0793[ce], model.rxns: r_3112, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3113 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3113, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3114 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3114, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3115 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3115, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3116 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3116, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3117 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3117, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3118 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3118, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3119 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3119, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3120 0 2 H3 "for model.mets: s_0794[c], model.rxns: r_3120, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3121 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3121, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3122 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3122, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3123 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3123, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3124 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3124, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3125 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3125, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3126 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3126, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3127 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3127, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3128 0 2 H3 "for model.mets: s_2783[erm], model.rxns: r_3128, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3129 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3129, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3130 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3130, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3131 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3131, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3132 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3132, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3133 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3133, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3134 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3134, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3135 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3135, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3136 0 2 H3 "for model.mets: s_3146[gm], model.rxns: r_3136, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3137 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3137, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3138 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3138, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3139 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3139, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3140 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3140, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3141 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3141, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3142 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3142, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3143 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3143, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3144 0 2 H3 "for model.mets: s_0793[ce], model.rxns: r_3144, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3145 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3145, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3146 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3146, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3147 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3147, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3148 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3148, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3149 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3149, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3150 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3150, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3151 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3151, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3152 0 2 H3 "for model.mets: s_0794[c], model.rxns: r_3152, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3153 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3153, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3154 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3154, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3155 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3155, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3156 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3156, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3157 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3157, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3158 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3158, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3159 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3159, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3160 0 2 H3 "for model.mets: s_2783[erm], model.rxns: r_3160, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3161 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3161, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3162 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3162, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3163 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3163, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3164 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3164, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3165 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3165, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3166 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3166, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3167 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3167, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3168 0 2 H3 "for model.mets: s_3146[gm], model.rxns: r_3168, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3169 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3169, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3170 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3170, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3171 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3171, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3172 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3172, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3173 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3173, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3174 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3174, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3175 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3175, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3176 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3176, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3177 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3177, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3178 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3178, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3179 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3179, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3180 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3180, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3181 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3181, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3182 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3182, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3183 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3183, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3184 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3184, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3185 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3185, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3186 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3186, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3187 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3187, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3188 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3188, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3189 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3189, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3190 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3190, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3191 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3191, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3192 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3192, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3193 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3193, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3194 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3194, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3195 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3195, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3196 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3196, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3197 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3197, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3198 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3198, change model.S coefficient from 0 to 2 to balance equation" [] +s_0793[ce] r_3199 0 2 H2 "for model.mets: s_0793[ce], model.rxns: r_3199, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3200 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3200, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3201 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3201, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3202 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3202, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3203 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3203, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3204 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3204, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3205 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3205, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3206 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3206, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3207 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3207, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3208 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3208, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3209 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3209, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3210 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3210, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3211 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3211, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3212 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3212, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3213 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3213, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3214 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3214, change model.S coefficient from 0 to 2 to balance equation" [] +s_2783[erm] r_3215 0 2 H2 "for model.mets: s_2783[erm], model.rxns: r_3215, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3216 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3216, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3217 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3217, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3218 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3218, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3219 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3219, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3220 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3220, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3221 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3221, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3222 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3222, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3223 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3223, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3224 1 2 H3 "for model.mets: s_3164[vm], model.rxns: r_3224, change model.S coefficient from 1 to 2 to balance equation" [] +s_3164[vm] r_3225 1 2 H1 "for model.mets: s_3164[vm], model.rxns: r_3225, change model.S coefficient from 1 to 2 to balance equation" [] +s_3164[vm] r_3226 1 2 H1 "for model.mets: s_3164[vm], model.rxns: r_3226, change model.S coefficient from 1 to 2 to balance equation" [] +s_3164[vm] r_3227 1 2 H1 "for model.mets: s_3164[vm], model.rxns: r_3227, change model.S coefficient from 1 to 2 to balance equation" [] +s_3164[vm] r_3228 1 2 H3 "for model.mets: s_3164[vm], model.rxns: r_3228, change model.S coefficient from 1 to 2 to balance equation" [] +s_3164[vm] r_3229 1 2 H1 "for model.mets: s_3164[vm], model.rxns: r_3229, change model.S coefficient from 1 to 2 to balance equation" [] +s_3164[vm] r_3230 1 2 H1 "for model.mets: s_3164[vm], model.rxns: r_3230, change model.S coefficient from 1 to 2 to balance equation" [] +s_3164[vm] r_3231 1 2 H1 "for model.mets: s_3164[vm], model.rxns: r_3231, change model.S coefficient from 1 to 2 to balance equation" [] +s_3146[gm] r_3232 1 2 H3 "for model.mets: s_3146[gm], model.rxns: r_3232, change model.S coefficient from 1 to 2 to balance equation" [] +s_3146[gm] r_3233 1 2 H1 "for model.mets: s_3146[gm], model.rxns: r_3233, change model.S coefficient from 1 to 2 to balance equation" [] +s_3146[gm] r_3234 1 2 H1 "for model.mets: s_3146[gm], model.rxns: r_3234, change model.S coefficient from 1 to 2 to balance equation" [] +s_3146[gm] r_3235 1 2 H1 "for model.mets: s_3146[gm], model.rxns: r_3235, change model.S coefficient from 1 to 2 to balance equation" [] +s_3146[gm] r_3236 1 2 H3 "for model.mets: s_3146[gm], model.rxns: r_3236, change model.S coefficient from 1 to 2 to balance equation" [] +s_3146[gm] r_3237 1 2 H1 "for model.mets: s_3146[gm], model.rxns: r_3237, change model.S coefficient from 1 to 2 to balance equation" [] +s_3146[gm] r_3238 1 2 H1 "for model.mets: s_3146[gm], model.rxns: r_3238, change model.S coefficient from 1 to 2 to balance equation" [] +s_3146[gm] r_3239 1 2 H1 "for model.mets: s_3146[gm], model.rxns: r_3239, change model.S coefficient from 1 to 2 to balance equation" [] +s_0794[c] r_3240 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3240, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3241 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3241, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3242 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3242, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_3243 0 2 H2 "for model.mets: s_0794[c], model.rxns: r_3243, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3244 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3244, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3245 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3245, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3246 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3246, change model.S coefficient from 0 to 2 to balance equation" [] +s_3164[vm] r_3247 0 2 H2 "for model.mets: s_3164[vm], model.rxns: r_3247, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3248 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3248, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3249 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3249, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3250 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3250, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3251 0 2 H2 "for model.mets: s_3146[gm], model.rxns: r_3251, change model.S coefficient from 0 to 2 to balance equation" [] +s_3146[gm] r_3332 0 -1 H-3 "for model.mets: s_3146[gm], model.rxns: r_3332, change model.S coefficient from 0 to -1 to balance equation" [] +s_3146[gm] r_3333 0 -1 H-1 "for model.mets: s_3146[gm], model.rxns: r_3333, change model.S coefficient from 0 to -1 to balance equation" [] +s_3146[gm] r_3334 0 -1 H-1 "for model.mets: s_3146[gm], model.rxns: r_3334, change model.S coefficient from 0 to -1 to balance equation" [] +s_3146[gm] r_3335 0 -1 H-1 "for model.mets: s_3146[gm], model.rxns: r_3335, change model.S coefficient from 0 to -1 to balance equation" [] +s_3146[gm] r_3336 0 -1 H-3 "for model.mets: s_3146[gm], model.rxns: r_3336, change model.S coefficient from 0 to -1 to balance equation" [] +s_3146[gm] r_3337 0 -1 H-1 "for model.mets: s_3146[gm], model.rxns: r_3337, change model.S coefficient from 0 to -1 to balance equation" [] +s_3146[gm] r_3338 0 -1 H-1 "for model.mets: s_3146[gm], model.rxns: r_3338, change model.S coefficient from 0 to -1 to balance equation" [] +s_3146[gm] r_3339 0 -1 H-1 "for model.mets: s_3146[gm], model.rxns: r_3339, change model.S coefficient from 0 to -1 to balance equation" [] +s_3164[vm] r_3340 0 -1 H-3 "for model.mets: s_3164[vm], model.rxns: r_3340, change model.S coefficient from 0 to -1 to balance equation" [] +s_3164[vm] r_3341 0 -1 H-1 "for model.mets: s_3164[vm], model.rxns: r_3341, change model.S coefficient from 0 to -1 to balance equation" [] +s_3164[vm] r_3342 0 -1 H-1 "for model.mets: s_3164[vm], model.rxns: r_3342, change model.S coefficient from 0 to -1 to balance equation" [] +s_3164[vm] r_3343 0 -1 H-1 "for model.mets: s_3164[vm], model.rxns: r_3343, change model.S coefficient from 0 to -1 to balance equation" [] +s_3164[vm] r_3344 0 -1 H-3 "for model.mets: s_3164[vm], model.rxns: r_3344, change model.S coefficient from 0 to -1 to balance equation" [] +s_3164[vm] r_3345 0 -1 H-1 "for model.mets: s_3164[vm], model.rxns: r_3345, change model.S coefficient from 0 to -1 to balance equation" [] +s_3164[vm] r_3346 0 -1 H-1 "for model.mets: s_3164[vm], model.rxns: r_3346, change model.S coefficient from 0 to -1 to balance equation" [] +s_3164[vm] r_3347 0 -1 H-1 "for model.mets: s_3164[vm], model.rxns: r_3347, change model.S coefficient from 0 to -1 to balance equation" [] +s_0805[e] r_4042 0 -1 O-1H-2 "for model.mets: s_0805[e], model.rxns: r_4042, change model.S coefficient from 0 to -1 to balance equation" | Hydrolase reaction +s_0799[m] r_4155 2 1 [] "for model.mets: s_0799[m], model.rxns: r_4155, change model.S coefficient from 2 to 1 to balance equation" | Reference to MetaCycID 6.3.5.7-RXN +s_0794[c] r_4186 0 1 N1H1R2 "for model.mets: s_0794[c], model.rxns: r_4186, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_4202 0 1 N1H1R2 "for model.mets: s_0794[c], model.rxns: r_4202, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_4218 0 1 [] "for model.mets: s_0794[c], model.rxns: r_4218, change model.S coefficient from 0 to 1 to balance equation" [] +s_0795[er] r_4250 0 -1 H-1R1 "for model.mets: s_0795[er], model.rxns: r_4250, change model.S coefficient from 0 to -1 to balance equation" [] +s_0799[m] r_4251 1 -1 H-2 "for model.mets: s_0799[m], model.rxns: r_4251, change model.S coefficient from 1 to -1 to balance equation" [] +s_0795[er] r_4253 1 -1 H-1R1 "for model.mets: s_0795[er], model.rxns: r_4253, change model.S coefficient from 1 to -1 to balance equation" [] +s_0801[p] r_4279 -1 1 H4 "for model.mets: s_0801[p], model.rxns: r_4279, change model.S coefficient from -1 to 1 to balance equation" [] +s_0794[c] r_4297 1 2 H1 "for model.mets: s_0794[c], model.rxns: r_4297, change model.S coefficient from 1 to 2 to balance equation" [] +s_0794[c] r_4299 1 2 H1 "for model.mets: s_0794[c], model.rxns: r_4299, change model.S coefficient from 1 to 2 to balance equation" [] +s_0794[c] r_4301 1 2 H1 "for model.mets: s_0794[c], model.rxns: r_4301, change model.S coefficient from 1 to 2 to balance equation" [] +s_1198[c] r_4303 0 -1 H1 "for model.mets: s_1198[c], model.rxns: r_4303, change model.S coefficient from 0 to -1 to balance equation" | Reference to UniProt Q04458 +s_1203[c] r_4303 0 1 H1 "for model.mets: s_1203[c], model.rxns: r_4303, change model.S coefficient from 0 to 1 to balance equation" | Reference to UniProt Q04458 +s_1198[c] r_4304 0 -1 H1 "for model.mets: s_1198[c], model.rxns: r_4304, change model.S coefficient from 0 to -1 to balance equation" | Reference to UniProt Q04458 +s_1203[c] r_4304 0 1 H1 "for model.mets: s_1203[c], model.rxns: r_4304, change model.S coefficient from 0 to 1 to balance equation" | Reference to UniProt Q04458 +s_0794[c] r_4305 1 2 H1 "for model.mets: s_0794[c], model.rxns: r_4305, change model.S coefficient from 1 to 2 to balance equation" [] +s_0794[c] r_4306 1 2 H1 "for model.mets: s_0794[c], model.rxns: r_4306, change model.S coefficient from 1 to 2 to balance equation" [] +s_0794[c] r_4307 1 2 H1 "for model.mets: s_0794[c], model.rxns: r_4307, change model.S coefficient from 1 to 2 to balance equation" [] +s_0795[er] r_4313 1 0 H-1 "for model.mets: s_0795[er], model.rxns: r_4313, change model.S coefficient from 1 to 0 to balance equation" [] +s_0795[er] r_4320 1 -1 H-2R1 "for model.mets: s_0795[er], model.rxns: r_4320, change model.S coefficient from 1 to -1 to balance equation" [] +s_0795[er] r_4321 1 -1 H-2R1 "for model.mets: s_0795[er], model.rxns: r_4321, change model.S coefficient from 1 to -1 to balance equation" [] +s_0799[m] r_4326 1 2 H1 "for model.mets: s_0799[m], model.rxns: r_4326, change model.S coefficient from 1 to 2 to balance equation" [] +s_0795[er] r_4328 0 2 H2R-1 "for model.mets: s_0795[er], model.rxns: r_4328, change model.S coefficient from 0 to 2 to balance equation" [] +s_0794[c] r_4374 0 1 H1 "for model.mets: s_0794[c], model.rxns: r_4374, change model.S coefficient from 0 to 1 to balance equation" [] +s_4112[c] r_4382 -1 1 H-4 "for model.mets: s_4112[c], model.rxns: r_4382, change model.S coefficient from -1 to 1 to balance equation" [] +s_4113[c] r_4382 2 -2 H-4 "for model.mets: s_4113[c], model.rxns: r_4382, change model.S coefficient from 2 to -2 to balance equation" [] +s_0794[c] r_4411 0 1 H1 "for model.mets: s_0794[c], model.rxns: r_4411, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_4432 1 2 H1 "for model.mets: s_0794[c], model.rxns: r_4432, change model.S coefficient from 1 to 2 to balance equation" [] +s_0803[c] r_4567 0 -1 O-1H-2 "for model.mets: s_0803[c], model.rxns: r_4567, change model.S coefficient from 0 to 1 to balance equation" | Hydrolase reaction +s_0529[c] r_4571 0 -1 C-21N-7O-15S-1P-3H-34 "for model.mets: s_0529[c], model.rxns: r_4571, change model.S coefficient from 0 to -1 to balance equation" [] +s_0794[c] r_4571 3 -1 C-21N-7O-15S-1P-3H-34 "for model.mets: s_0794[c], model.rxns: r_4571, change model.S coefficient from 3 to -1 to balance equation" [] +s_0803[c] r_4571 0 1 C-21N-7O-15S-1P-3H-34 "for model.mets: s_0803[c], model.rxns: r_4571, change model.S coefficient from 0 to 1 to balance equation" [] +s_4186[c] r_4578 1 0 H-2 "for model.mets: s_4186[c], model.rxns: r_4578, change model.S coefficient from 1 to 0 to balance equation" [] +s_4185[c] r_4578 0 1 H-2 "for model.mets: s_4185[c], model.rxns: r_4578, change model.S coefficient from 0 to 1 to balance equation" [] +s_0794[c] r_4578 1 -1 H-2 "for model.mets: s_0794[c], model.rxns: r_4578, change model.S coefficient from 1 to -1 to balance equation" [] +% diff --git a/ComplementaryData/modelCuration/modifyID.tsv b/ComplementaryData/modelCuration/modifyID.tsv new file mode 100644 index 00000000..d92268b0 --- /dev/null +++ b/ComplementaryData/modelCuration/modifyID.tsv @@ -0,0 +1,260 @@ +% +#for modification of rxnID and/or notation of alternative rxnID #Note: rxnID will be removed if the reaction described is significantly different from the reaction in model +#model.rxns model.rxnMetaNetXID new_MNXRID alternative_MNXRID model.rxnKEGGID new_rxnKEGGID alternative_rxnKEGGID Notes MNXNotes KEGGNotes +r_0001 MNXR106428 MNXR138960 [] R00197 [] [] r_0001: changed MNXRID MNXR106428 to MNXR138960 | MNXRID MNXR106428 is deprecated in MNX database [] +r_0002 MNXR106428 MNXR138960 [] R00197 [] [] r_0002: changed MNXRID MNXR106428 to MNXR138960 | MNXRID MNXR106428 is deprecated in MNX database [] +r_0004 MNXR106427 MNXR138959 [] R00196 [] [] r_0004: changed MNXRID MNXR106427 to MNXR138959 | MNXRID MNXR106427 is deprecated in MNX database [] +r_0005 MNXR107959 MNXR143499 [] R03118 [] [] r_0005: changed MNXRID MNXR107959 to MNXR143499 | MNXRID MNXR107959 is deprecated in MNX database [] +r_0014 MNXR112805 [] [] [] R09377 [] r_0014: added new rxnKEGGID R09377 into model [] | R09377 is linked to MNXR112805 as external resources in MNX database +r_0027 MNXR108174 MNXR141287 [] R03444 [] [] r_0027: changed MNXRID MNXR108174 to MNXR141287 | MNXRID MNXR108174 is deprecated in MNX database [] +r_0058 MNXR94889 [] [] [] R02665 [] r_0058: added new rxnKEGGID R02665 into model [] | R02665 is linked to MNXR94889 as external resources in MNX database +r_0072 MNXR95033 MNXR137950 [] [] [] [] r_0072: changed MNXRID MNXR95033 to MNXR137950 | MNXRID MNXR95033 is deprecated in MNX database [] +r_0086 MNXR101445 MNXR125830 [] R07392 [] [] r_0086: changed MNXRID MNXR101445 to MNXR125830 | MNXRID MNXR101445 is deprecated in MNX database [] +r_0093 [] [] MNXR112453 [] [] R08964 r_0093: alternative MNXRID MNXR112453 found | alternative rxnKEGGID R08964 found [] [] +r_0179 MNXR95720 MNXR138038 [] R05685 [] [] r_0179: changed MNXRID MNXR95720 to MNXR138038 | MNXRID MNXR95720 is deprecated in MNX database [] +r_0180 MNXR95720 MNXR138038 [] R05685 [] [] r_0180: changed MNXRID MNXR95720 to MNXR138038 | MNXRID MNXR95720 is deprecated in MNX database [] +r_0181 MNXR95721 MNXR138039 [] R05686 [] [] r_0181: changed MNXRID MNXR95721 to MNXR138039 | MNXRID MNXR95721 is deprecated in MNX database [] +r_0188 MNXR95665 MNXR139295 [] R04620 [] [] r_0188: changed MNXRID MNXR95665 to MNXR139295 | MNXRID MNXR95665 is deprecated in MNX database [] +r_0189 MNXR95767 [] [] [] R02422 [] r_0189: added new rxnKEGGID R02422 into model [] | R02422 is linked to MNXR95767 as external resources in MNX database +r_0195 MNXR104927 MNXR143415 [] R00836 [] [] r_0195: changed MNXRID MNXR104927 to MNXR143415 | MNXRID MNXR104927 is deprecated in MNX database [] +r_0198 MNXR101717 MNXR101350 [] R01555 R00028 R06084 r_2116: changed MNXRID MNXR101717 to MNXR101350 | changed rxnKEGGID R01555 to R00028 | alternative rxnKEGGID R06084 found | Incorrect mets (phosphate and beta-D-glucose 1-phosphate) involved in MNXR101717 | MNXR101350 matches reaction and all MNXMID in r_0198 | R00028 is linked to MNXR101350 as external resources in MNX database | R06084 is linked to R00028 +r_0207 MNXR95948 MNXR138059 [] R01086 [] [] r_0207: changed MNXRID MNXR95948 to MNXR138059 | MNXRID MNXR95948 is deprecated in MNX database [] +r_0208 MNXR95949 MNXR138060 [] R01954 [] [] r_0208: changed MNXRID MNXR95949 to MNXR138060 | MNXRID MNXR95949 is deprecated in MNX database [] +r_0255 MNXR96455 [] [] [] R00009 [] r_0255: added new rxnKEGGID R00009 into model [] | R00009 is linked to MNXR96455 as external resources in MNX database +r_0264 MNXR110315 MNXR126619 MNXR110315 R06517 [] [] r_0264: changed MNXRID MNXR110315 to MNXR126619 | alternative MNXRID MNXR110315 found | Incorrect mets (N-acylsphinganine and an acyl-CoA) involved in MNXR110315 | MNXR110315 matches reaction and all MNXMID in r_0264 [] +r_0266 MNXR110323 MNXR126618 MNXR110323 R06527 [] [] r_0266: changed MNXRID MNXR110323 to MNXR126618 | alternative MNXRID MNXR110323 found | Incorrect mets (C26-CoA and N-acyl-4-hydroxysphinganine) involved in MNXR110315 | MNXR110323 matches reaction and all MNXMID in r_0266 [] +r_0271 MNXR107444 [] MNXR96718 R02333 [] [] r_0271: alternative MNXRID MNXR96718 found [] [] +r_0346 MNXR97403 MNXR140043 [] R02237 [] [] r_0346: changed MNXRID MNXR97403 to MNXR140043 | MNXRID MNXR97403 is deprecated in MNX database [] +r_0348 MNXR97679 MNXR126238 [] R04621 [] [] r_0348: changed MNXRID MNXR97679 to MNXR126238 | MNXRID MNXR97679 is deprecated in MNX database [] +r_0350 MNXR107926 MNXR140386 [] R03066 [] [] r_0350: changed MNXRID MNXR107926 to MNXR140386 | MNXRID MNXR107926 is deprecated in MNX database [] +r_0351 MNXR97439 MNXR140085 [] R03067 [] [] r_0351: changed MNXRID MNXR97439 to MNXR140085 | MNXRID MNXR97439 is deprecated in MNX database [] +r_0437 MNXR106340 MNXR138164 [] R00017 [] [] r_0437: changed MNXRID MNXR106340 to MNXR138164 | MNXRID MNXR106340 is deprecated in MNX database [] +r_0438 MNXR106380 MNXR138955 [] R00081 [] [] r_0438: changed MNXRID MNXR106380 to MNXR138955 | MNXRID MNXR106380 is deprecated in MNX database [] +r_0449 MNXR106670 [] MNXR144209 R00762 [] [] r_0449: alternative MNXRID MNXR144209 found [] [] +r_0467 MNXR106678 [] MNXR130328 R00771 [] [] r_0467: alternative MNXRID MNXR130328 found [] [] +r_0477 MNXR106675 [] MNXR124393 R00768 [] [] r_0477: alternative MNXRID MNXR124393 found [] [] +r_0502 MNXR100142 [] MNXR124474 R00945 [] [] r_0502: alternative MNXRID MNXR124474 found [] [] +r_0503 MNXR100142 [] MNXR124474 R00945 [] [] r_0503: alternative MNXRID MNXR124474 found [] [] +r_0507 [] MNXR100068 [] [] R04125 [] r_0507: added new MNXRID MNXR100068 | added new rxnKEGGID R04125 into model "| MNXR100068 matches reaction and all MNXMID (except MNXM1, added to balance equation) in r_0507" | R04125 is linked to MNXR100068 as external resource in MNX database +r_0510 MNXR100224 MNXR143136 [] [] [] [] r_0510: changed MNXRID MNXR100224 to MNXR143136 | MNXRID MNXR100224 is deprecated in MNX database [] +r_0518 MNXR95257 [] MNXR95258 R03482 R05917 [] r_0518: alternative MNXRID MNXR95258 found | changed rxnKEGGID R03482 to R05917 "| MNXR95258 contains MNXMID MNXM92477 in previous r_0518, which has been replaced by new MNXMID MNXM999 in new r_0518" "| R05917 is the updated version of R03482, see remarks in KEGG database" +r_0541 MNXR95957 MNXR141861 [] R01159 [] [] r_0541: changed MNXRID MNXR95957 to MNXR141861 | MNXRID MNXR95957 is deprecated in MNX database [] +r_0543 MNXR106445 MNXR141692 [] R00271 [] [] r_0543: changed MNXRID MNXR106445 to MNXR141692 | MNXRID MNXR106445 is deprecated in MNX database [] +r_0550 [] MNXR104815 [] [] [] [] r_0550: added new MNXRID MNXR104815 into model | MNXR104815 matches reaction and all MNXMID in r_0550 [] +r_0551 [] MNXR104815 [] [] [] [] r_0551: added new MNXRID MNXR104815 into model | MNXR104815 matches reaction and all MNXMID in r_0551 [] +r_0552 [] MNXR104815 [] [] [] [] r_0552: added new MNXRID MNXR104815 into model | MNXR104815 matches reaction and all MNXMID in r_0552 [] +r_0558 MNXR107304 [] MNXR100659 R02082 [] [] r_0558: alternative MNXRID MNXR100659 found [] [] +r_0559 MNXR107257 [] MNXR100660 R01978 [] [] r_0559: alternative MNXRID MNXR100660 found [] [] +r_0723 MNXR106679 [] MNXR124423 R00772 [] [] r_0723: alternative MNXRID MNXR124423 found [] [] +r_0728 MNXR99604 [] MNXR124973 R03940 [] [] r_0728: alternative MNXRID MNXR124973 found [] [] +r_0760 MNXR95248 [] MNXR124394 R02058 [] [] r_0760: alternative MNXRID MNXR124394 found [] [] +r_0763 [] MNXR101947 [] [] [] [] r_0763: added new MNXRID MNXR101947 into model | MNXR101947 matches reaction and all MNXMID in r_0763 [] +r_0851 MNXR102631 MNXR126234 [] R00694 [] [] r_0851: changed MNXRID MNXR102631 to MNXR126234 | MNXRID MNXR102631 is deprecated in MNX database [] +r_0854 MNXR103152 MNXR125761 [] R01377 [] [] r_0854: changed MNXRID MNXR103152 to MNXR125761 | MNXRID MNXR103152 is deprecated in MNX database [] +r_0855 MNXR108734 MNXR139261 MNXR108734 R04208 [] [] r_0855: changed MNXRID MNXR108734 to MNXR139261 | alternative MNXRID MNXR108734 found | MNXR139261 is linked to R04208 as external resource in MNX database [] +r_0911 MNXR108735 [] MNXR136160 R04209 Blank "R07404, R7405" "r_0911: alternative MNXRID MNXR136160 found | rxnKEGGID R04209 removed from model | alternative rxnKEGGIDs R07404, R7405 found" [] | R4209 removed as it does not match reaction in model +r_0920 MNXR110323 MNXR126694 MNXR110323 R06527 [] [] r_0920: changed MNXRID MNXR110323 to MNXR126694 | alternative MNXRID MNXR110323 found "| Incorrect mets (C26-CoA, CoA and N-acyl-4-hydroxysphinganine) involved in MNXR110323 | MNXR126694 matches reaction and all MNXMID (except MNXM2, added to balance eqn) in r_0920" [] +r_0922 MNXR110321 MNXR103263 MNXR110321 R06525 [] [] r_0922: changed MNXRID MNXR110321 to MNXR103263 | alternative MNXRID MNXR110321 found | Incorrect mets (ferricytochrome b5 and ferrocytochrome b5) involved in MNXR110321 | MNXR103263 matches reaction and all MNXMID in r_0922 [] +r_0938 MNXR103123 MNXR126086 [] R01373 [] [] r_0938: changed MNXRID MNXR103123 to MNXR126086 | MNXRID MNXR103123 is deprecated in MNX database [] +r_0969 MNXR103431 [] [] [] R01051 [] r_2113: added new rxnKEGGID R01051 into model [] [] +r_0970 MNXR104070 [] MNXR137376 R02014 [] [] r_0970: alternative MNXRID MNXR137376 found [] [] +r_0971 MNXR104076 [] MNXR137378 R02022 [] [] r_0971: alternative MNXRID MNXR137378 found [] [] +r_0972 MNXR104073 [] MNXR137377 R02020 [] [] r_0972: alternative MNXRID MNXR137377 found [] [] +r_0973 MNXR104079 [] MNXR137379 R02023 [] [] r_0973: alternative MNXRID MNXR137379 found [] [] +r_0974 MNXR104060 [] MNXR137337 R02017 [] [] r_0974: alternative MNXRID MNXR137337 found [] [] +r_0975 MNXR104060 [] MNXR137337 R02017 [] [] r_0975: alternative MNXRID MNXR137337 found [] [] +r_0976 MNXR104064 [] MNXR137339 R02024 [] [] r_0976: alternative MNXRID MNXR137339 found [] [] +r_0977 MNXR104064 [] MNXR137339 R02024 [] [] r_0977: alternative MNXRID MNXR137339 found [] [] +r_0978 MNXR104062 [] MNXR137338 R02019 [] [] r_0978: alternative MNXRID MNXR137338 found [] [] +r_0979 MNXR104062 [] MNXR137338 R02019 [] [] r_0979: alternative MNXRID MNXR137338 found [] [] +r_1000 MNXR99636 MNXR129857 MNXR99636 R00408 [] [] r_1000: changed MNXRID MNXR99636 to MNXR129857 | Incorrect mets (FAD and FADH2) involved in MNXR99636 | MNXR129857 matches reaction and all MNXMID in r_1000 [] +r_1031 MNXR106759 MNXR143412 [] R00942 [] [] r_1031: changed MNXRID MNXR106759 to MNXR143412 | MNXRID MNXR106759 is deprecated in MNX database [] +r_1032 MNXR104817 MNXR138860 [] [] [] [] r_1032: changed MNXRID MNXR104817 to MNXR138860 | MNXRID MNXR104817 is deprecated in MNX database [] +r_1037 [] MNXR104815 [] [] [] [] r_1037: added new MNXRID MNXR104815 into model | MNXR104815 matches reaction and all MNXMID in r_1037 [] +r_1038 MNXR104766 [] MNXR137353 R02016 [] [] r_1038: alternative MNXRID MNXR137353 found [] [] +r_1039 MNXR104766 [] MNXR137353 R02016 [] [] r_1039: alternative MNXRID MNXR137353 found [] [] +r_1070 MNXR105057 MNXR143428 [] [] R00291 [] r_1070: changed MNXRID MNXR105057 to MNXR143428 | added new rxnKEGGID R00291 into model | MNXRID MNXR105057 is deprecated in MNX database | R00291 is linked to MNXR143428 as external resources in MNX database +r_1071 MNXR105090 MNXR143436 [] R00955 [] [] r_1071: changed MNXRID MNXR105090 to MNXR143436 | MNXRID MNXR105090 is deprecated in MNX database [] +r_1084 MNXR100022 MNXR143121 [] R00289 [] [] r_1084: changed MNXRID MNXR100022 to MNXR143121 | MNXRID MNXR100022 is deprecated in MNX database [] +r_1270 MNXR104828 MNXR138863 [] [] [] [] r_1270: changed MNXRID MNXR104828 to MNXR138863 | MNXRID MNXR104828 is deprecated in MNX database [] +r_1599 MNXR94913 MNXR137944 [] [] [] [] r_1599: changed MNXRID MNXR94913 to MNXR137944 | MNXRID MNXR94913 is deprecated in MNX database [] +r_1600 MNXR94913 MNXR137944 [] [] [] [] r_1600: changed MNXRID MNXR94913 to MNXR137944 | MNXRID MNXR94913 is deprecated in MNX database [] +r_1714 MNXR99986 MNXR138465 [] [] [] [] r_1714: changed MNXRID MNXR99986 to MNXR138465 | MNXRID MNXR99986 is deprecated in MNX database [] +r_1745 MNXR97446 MNXR142733 [] [] [] [] r_1745: changed MNXRID MNXR97446 to MNXR142733 | MNXRID MNXR97446 is deprecated in MNX database [] +r_1810 MNXR125443 Blank [] [] [] [] r_1810: MNXRID MNXR125443 removed from model | MNXRID MNXR125443 is deprecated in MNX database [] +r_1838 MNXR106445 MNXR141692 [] [] [] [] r_1838: changed MNXRID MNXR106445 to MNXR141692 | MNXRID MNXR106445 is deprecated in MNX database [] +r_1989 MNXR106490 MNXR125856 [] [] [] [] r_1989: changed MNXRID MNXR106490 to MNXR125856 | MNXRID MNXR106490 is deprecated in MNX database [] +r_2112 MNXR99596 MNXR132503 MNXR99596 R01959 [] [] r_2112: changed MNXRID MNXR99596 to MNXR132503 | alternative MNXRID MNXR99596 found "| Incorrect mets (N-formyl-L-kynurenine zwitterion, formate, H2O and H+) involved in MNXR99596 | MNXR132503 matches reaction and all MNXMID in r_2112" [] +r_2113 [] MNXR108341 [] [] R03687 [] r_2113: added new MNXRID MNXR108341 into model | added new rxnKEGGID R03687 into model [] | R03687 contains updated information on the reaction which matches r_2113 +r_2116 MNXR95750 MNXR95749 [] R00711 R00710 [] r_2116: changed MNXRID MNXR95750 to MNXR95749 | changed rxnKEGGID R00711 to R00710 | Incorrect mets (NADPH and NADP) involved in MNXR95750 | MNXR95749 matches reaction and all MNXMID in r_2116 [] +r_2117 MNXR102631 MNXR125716 [] R00694 R00692 [] r_2117: changed MNXRID MNXR102631 to MNXR125716 | changed rxnKEGGID from R00694 to R00692 | MNXRID MNXR102631 is deprecated in MNX database and does not match current model reaction | MNXRID MNXR125716 matches model reaction and all current MNXMIDs | R00692 is linked to MNXR125716 as external resources in MNX database +r_2125 MNXR106428 MNXR138960 [] R00197 [] [] r_2125: changed MNXRID MNXR106428 to MNXR138960 | MNXRID MNXR106428 is deprecated in MNX database [] +r_2147 [] MNXR137225 [] [] [] [] r_2147: added new MNXRID MNXR137225 into model | MNXR137225 matches reaction in r_2147 [] +r_2150 [] MNXR137214 [] [] [] [] r_2150: added new MNXRID MNXR137214 into model | MNXR137225 matches reaction (but has an additional H+) in r_2147 [] +r_2166 MNXR103459 MNXR118005 [] [] [] [] r_2166: changed MNXRID MNXR103459 to MNXR118005 | MNXRID MNXR103459 is deprecated in MNX database [] +r_2173 [] MNXR118009 [] [] [] [] r_2173: added new MNXRID MNXR118009 into model | MNXR118009 matches reaction and all MNXMID in r_2173 [] +r_2236 [] MNXR127857 [] [] [] [] r_2236: added new MNXRID MNXR127857 into model | MNXR127857 matches reaction and all MNXMID in r_2236 [] +r_2237 [] MNXR127546 [] [] [] [] r_2237: added new MNXRID MNXR127546 into model | MNXR127546 matches reaction and all MNXMID in r_2237 [] +r_2241 [] MNXR127548 [] [] [] [] r_2241: added new MNXRID MNXR127548 into model | MNXR127548 matches reaction and all MNXMID in r_2241 [] +r_2256 [] MNXR118594 [] [] [] [] r_2256: added new MNXRID MNXR118594 into model | MNXR118594 matches reaction and all MNXMID in r_2256 [] +r_2259 [] MNXR118009 [] [] [] [] r_2259: added new MNXRID MNXR118009 into model | MNXR118009 matches reaction and all MNXMID in r_2259 [] +r_4152 MNXR100594 MNXR138510 [] R02480 [] [] r_4152: changed MNXRID MNXR100594 to MNXR138510 | MNXRID MNXR100594 is deprecated in MNX database [] +r_4186 MNXR101484 [] MNXR139547 R07606 [] [] r_4186: alternative MNXRID MNXR139547 found [] [] +r_4189 MNXR109090 MNXR143540 [] R04734 [] [] r_4189: changed MNXRID MNXR109090 to MNXR143540 | MNXRID MNXR109090 is deprecated in MNX database [] +r_4199 MNXR108227 MNXR125877 [] R03522 [] [] r_4199: changed MNXRID MNXR108227 to MNXR125877 | MNXRID MNXR108227 is deprecated in MNX database [] +r_4200 MNXR108227 MNXR125877 [] R03522 [] [] r_4200: changed MNXRID MNXR108227 to MNXR125877 | MNXRID MNXR108227 is deprecated in MNX database [] +r_4201 MNXR108227 MNXR125877 [] R03522 [] [] r_4201: changed MNXRID MNXR108227 to MNXR125877 | MNXRID MNXR108227 is deprecated in MNX database [] +r_4205 MNXR102200 MNXR138674 [] R00251 [] [] r_4205: changed MNXRID MNXR102200 to MNXR138674 | MNXRID MNXR102200 is deprecated in MNX database [] +r_4207 MNXR108227 MNXR125877 [] R03522 [] [] r_4207: changed MNXRID MNXR108227 to MNXR125877 | MNXRID MNXR108227 is deprecated in MNX database [] +r_4208 MNXR100442 MNXR138490 [] R01108 [] [] r_4208: changed MNXRID MNXR100442 to MNXR138490 | MNXRID MNXR100442 is deprecated in MNX database [] +r_4209 MNXR100442 MNXR138490 [] R01108 [] [] r_4209: changed MNXRID MNXR100442 to MNXR138490 | MNXRID MNXR100442 is deprecated in MNX database [] +r_4211 MNXR113465 MNXR140225 [] R10089 [] [] r_4211: changed MNXRID MNXR113465 to MNXR140225 | MNXRID MNXR113465 is deprecated in MNX database [] +r_4245 MNXR101397 [] [] R09645 Blank [] r_4186: rxnKEGGID R09645 removed from model [] | R09645 not found in KEGG database +r_4252 MNXR114005 MNXR139808 [] R10685 [] [] r_4252: changed MNXRID MNXR114005 to MNXR139808 | MNXRID MNXR114005 is deprecated in MNX database [] +r_4254 MNXR101997 MNXR101996 [] R05725 R05724 [] r_4254: changed MNXRID MNXR101997 to MNXR101996 | changed rxnKEGGID R05725 to R05724 | Incorrect mets (NADPH and NADP) involved in MNXR101997 | MNXR101996 matches reaction and all MNXMID in r_4254 | Incorrect mets (NADPH and NADP) involved in R05725 | R05724 matches reaction and all metKEGGID in r_4254 +r_4326 MNXR96956 MNXR138187 [] R01931 [] [] r_4326: changed MNXRID MNXR96956 to MNXR138187 | MNXRID MNXR96956 is deprecated in MNX database [] +r_4328 MNXR106784 MNXR143462 [] R01005 [] [] r_4328: changed MNXRID MNXR106784 to MNXR143462 | MNXRID MNXR106784 is deprecated in MNX database [] +r_4341 MNXR98598 MNXR100319 [] [] [] [] r_4341: changed MNXRID MNXR98598 to MNXR100319 | MNXRID MNXR98598 is deprecated in MNX database [] +r_4382 MNXR106345 MNXR138952 [] [] [] [] r_4382: changed MNXRID MNXR106345 to MNXR138952 | MNXRID MNXR106345 is deprecated in MNX database [] +r_4382 MNXR138952 [] [] [] R00029 [] r_4382: added new rxnKEGGID R00029 into model [] | R00029 is linked to MNXR138952 as external resources in MNX database +r_4390 MNXR96247 MNXR142673 [] [] [] [] r_4390: changed MNXRID MNXR96247 to MNXR142673 | MNXRID MNXR96247 is deprecated in MNX database [] +r_4392 MNXR137048 MNXR144815 [] [] [] [] r_4392: changed MNXRID MNXR137048 to MNXR144815 | MNXRID MNXR137048 is deprecated in MNX database [] +r_4453 MNXR98531 MNXR99915 [] [] [] [] r_4453: changed MNXRID MNXR98531 to MNXR99915 | MNXRID MNXR98531 is deprecated in MNX database [] +r_4489 MNXR95187 MNXR137988 [] R01903 [] [] r_4489: changed MNXRID MNXR95187 to MNXR137988 | MNXRID MNXR95187 is deprecated in MNX database [] +r_4494 MNXR98748 MNXR101464 [] [] [] [] r_4494: changed MNXRID MNXR98748 to MNXR101464 | MNXRID MNXR98748 is deprecated in MNX database [] +r_4568 MNXR110535 MNXR139469 [] R06790 [] [] r_4568: changed MNXRID MNXR110535 to MNXR139469 | MNXRID MNXR110535 is deprecated in MNX database [] +r_4577 MNXR137278 MNXR106867 [] [] R01209 [] r_4577: changed MNXRID MNXR137278 to MNXR106867 | added new rxnKEGGID R01209 into model "| Incorrect met (3-hydroxy-3-methyl-2-oxobutanoate) involved in MNXR137278 | MNXR106867 found based on metName Dihydroxy-acid dehydratase, mitochondrial | Reference to UniProt P32263" | R01209 found based on MNXR106867 +% +#for modification of metID and/or notation of alternative metID "#for lipids, note that the major forms of unsaturated fatty acids found in Saccharomyces cerevisiae are 16:1(9Z) and 18:1(9Z) (PMID: 19174513)" +#model.mets model.metMetaNetXID new_MNXMID alternative_MNXMID model.metKEGGID new_metKEGGID alternative_metKEGGID model.metChEBIID new_metChEBIID alternative_metChEBIID rxn/related rxn(s) Notes MNXNotes KEGGNotes ChEBINotes otherDatabaseNotes +s_0015[c] MNXM550 MNXM722743 [] C03406 [] [] CHEBI:57472 [] [] r_0207 s_0015[c]: changed MNXMID MNXM550 to MNXM722743 | MNXMID MNXM550 is deprecated in MNX database [] [] [] +s_0117[m] MNXM848 MNXM114091 [] C04281 [] [] CHEBI:18105 [] [] r_0672 s_0117[m]: changed MNXMID MNXM848 to MNXM114091 [] [] [] [] +s_0218[c] MNXM36493 MNXM197 [] C00356 [] [] CHEBI:16261 [] [] r_0558; r_0559 s_0218[c]: changed MNXMID MNXM36493 to MNXM197 [] [] [] [] +s_0279[c] MNXM37435 MNXM1715 [] [] C11526 [] CHEBI:11814 [] [] r_0073 s_0279[c]: changed MNXMID MNXM37435 to MNXM1715 | added new metKEGGID C11526 into model [] [] [] [] +s_0300[c] MNXM162266 MNXM388 [] C03373 [] [] CHEBI:52966 [] [] r_0855 s_0300[c]: changed MNXMID MNXM162266 to MNXM388 | MNXM388 is linked to C03373 as external resource in MNX database [] [] [] +s_0306[c] MNXM90098 MNXM183 [] C00143 [] [] CHEBI:53064 [] [] r_0080 s_0306[c]: changed MNXMID MNXM90098 to MNXM183 [] [] [] [] +s_0308[c] MNXM317 MNXM723480 [] C09332 [] [] CHEBI:27650 [] [] r_1031 s_0308[c]: changed MNXMID MNXM317 to MNXM723480 | MNXMID MNXM317 is deprecated in MNX database [] [] [] +s_0331[er] MNXM92477 MNXM999 [] C01288 [] [] CHEBI:52980 [] [] r_0518 s_0331[er]: changed MNXMID MNXM92477 to MNXM999 [] [] [] [] +s_0333[c] MNXM38670 MNXM1715 [] [] C11526 [] CHEBI:58592 [] [] r_0092 s_0333[c]: changed MNXMID MNXM38670 to MNXM1715 | added new metKEGGID C11526 into model [] [] [] [] +s_0347[c] MNXM965 MNXM722728 [] C00921 [] [] CHEBI:17839 [] [] r_0346 s_0347[c]: changed MNXMID MNXM965 to MNXM722728 | MNXMID MNXM965 is deprecated in MNX database [] [] [] +s_0412[c] MNXM162238 MNXM370 [] C00352 [] [] CHEBI:15873 [] [] r_0477 ; r_0760; r_0890 s_0412[c]: changed MNXMID MNXM162238 to MNXM370 [] [] [] [] +s_0510[ce] MNXM2106 [] MNXM48488 C00734 [] [] CHEBI:12071 [] [] r_0271 s_0510[ce]: alternative MNXMID MNXM48488 found [] [] [] [] +s_0555[c] MNXM500 MNXM417 [] C00354 [] [] CHEBI:57265 [] [] r_0449; r_0886 s_0555[c]: changed MNXMID MNXM500 to MNXM417 [] [] [] [] +s_0556[c] MNXM1553 MNXM145568 [] C01094 [] [] CHEBI:12071 [] [] r_0322 s_0556[c]: changed MNXMID MNXM1553 to MNXM145568 [] [] [] [] +s_0557[c] MNXM89629 MNXM162235 [] C00085 [] [] CHEBI:57579 [] [] r_0723 s_0557[c]: changed MNXMID MNXM89629 to MNXM162235 [] [] [] [] +s_0710[m] MNXM5749 MNXM746 [] C00126 [] [] CHEBI:58509 [] [] r_0001 s_0710[m]: changed MNXMID MNXM5749 to MNXM746 | Incorrect MNXMID MNXM5749 (ferricytochrome c) is replaced by MNXM746 (ferrocytochrome c) [] [] [] +s_0834[m] MNXM1056 MNXM722779 [] C01251 [] [] CHEBI:36457 [] [] r_0027 s_0834[m]: changed MNXMID MNXM1056 to MNXM722779 | MNXMID MNXM1056 is deprecated in MNX database [] [] [] +s_1035[c] MNXM114 [] [] C04281 C00148 [] CHEBI:57540 [] [] r_0941; r_0957 s_1035[c]: changed metKEGGID C04281 to C00148 [] [] [] [] +s_1149[m] MNXM28 MNXM90636 [] C02430 [] [] CHEBI:16928 [] [] r_0728 s_1149[m]: changed MNXMID MNXM28 to MNXM90636 "| MNXM90636 is linked to bigg:mettrna as external resource, verified metFormula C5H10NOSR to be correct | MNXM90636 is linked to C02430 as external resource" [] [] [] +s_1183[c] MNXM3309 MNXM722872 [] C01152 [] [] CHEBI:27596 [] [] r_0541 s_1183[c]: changed MNXMID MNXM3309 to MNXM722872 | MNXMID MNXM3309 is deprecated in MNX database [] [] [] +s_1185[c] MNXM63081 MNXM147516 [] [] [] [] CHEBI:58210 [] [] r_0763 s_1185[c]: changed MNXMID MNXM63081 to MNXM147516 "| N N bisformyl dityrosine in MNXM147516 is a traditional IUPAC Name of current metName N,N'-diformyldityrosine, selected as new MNXMID due to correct metFormula C20H22N2O8" [] [] [] +s_1507[p] MNXM580 [] [] C05275 [] [] [] CHEBI:61406 [] r_2295 s_1507[p]: added new metChEBIID CHEBI:61406 into model [] [] | New ChEBIID found based on MNXMID MNXM580 [] +s_1510[p] MNXM642 [] [] C03221 [] [] [] CHEBI:57330 [] r_2297 s_1510[p]: added new metChEBIID CHEBI:57330 into model [] [] | New ChEBIID found based on MNXMID MNXM642 [] +s_1543[c] MNXM52 MNXM722710 [] C00029 [] [] CHEBI:58367 [] [] r_0005 s_1543[c]: changed MNXMID MNXM52 to MNXM722710 | MNXMID MNXM52 is deprecated in MNX database [] [] [] +s_1617[m] MNXM155 MNXM96993 [] C00342 [] [] CHEBI:15967 CHEBI:15033 [] r_1039 s_1617[m]: changed MNXMID MNXM155 to MNXM96993 | changed metChEBIID CHEBI:15967 to CHEBI:15033 [] [] [] [] +s_2777[m] [] MNXM10033 [] C16220 [] [] [] [] [] r_2147 s_2777[m]: added new MNXMID MNXM10033 into model "| MNXM10033 matches metName 3-hydroxyoctanoyl-ACP, found in metabolic network maranas_iSce926_M11" [] [] [] +s_2780[m] [] MNXM23766 [] C05751 [] [] [] [] [] r_2147 s_2780[m]: added new MNXMID MNXM23766 into model | MNXM23766 is linked to C05751 as external resource [] [] [] +s_2806[erm] MNXM163185 MNXM36558 [] [] [] [] CHEBI:52326 [] [] r_2166 s_2806[erm]: changed MNXMID MNXM163185 to MNXM36558 | MNXMID MNXM163185 is deprecated in MNX database [] [] [] +s_2810[erm] [] MNXM581 [] C05272 [] [] [] [] [] r_2169 s_2810[erm]: added new MNXMID MNXM581 into model | MNXM581 is linked to C05272 as external resource [] [] [] +s_2812[erm] [] MNXM22115 [] [] [] [] CHEBI:76889 [] [] r_2178; r_2239 s_2812[erm]: added new MNXMID MNXM22115 into model "| MNXM22115 ((2E)-eicosenoyl-CoA) is linked to chebi:75061 as external resource, which is a synonym of metName trans-2-icosenoyl-CoA" [] [] [] +s_2813[erm] [] MNXM97615 [] [] [] [] CHEBI:75068 [] [] r_2172 s_2813[erm]: added new MNXMID MNXM97615 into model | MNXM97615 matches metName trans-docos-2-enoyl-CoA [] [] [] +s_2891[p] [] MNXM97616 MNXM165192 [] [] [] CHEBI:76453 [] [] r_2241 s_2891[p]: added new MNXMID MNXM97616 into model | alternative MNXMID MNXM165192 found | MNXM97616 is linked to current ChEBIID CHEBI:75068 [] [] [] +s_2892[p] [] MNXM146680 [] [] [] [] CHEBI:76889 CHEBI:78178 [] r_2260 s_2892[p]: added new MNXMID MNXM146680 into model | changed metChEBIID CHEBI:76889 to CHEBI:78178 | New MNXMID found based on ChEBIID CHEBI:78178 [] "| Wrong ChEBIID CHEBI:76889 ((9Z,12Z)-hexadecadienoyl-CoA), new ChEBIID CHEBI:78178 ((2E,9Z)-hexadecadienoyl-CoA) is found based on metName trans-2,cis-9-hexadecadienoyl-CoA" [] +s_2898[p] [] MNXM149511 [] [] [] [] CHEBI:88008 [] [] r_2292 s_2898[p]: added new MNXMID MNXM149511 into model | New MNXMID found based on ChEBIID CHEBI:88008 [] [] [] +s_2900[p] [] MNXM103862 [] [] [] [] CHEBI:70712 [] [] r_2293 s_2900[p]: added new MNXMID MNXM103862 into model | New MNXMID found based on ChEBIID CHEBI:70712 [] [] [] +s_2905[p] [] MNXM36530 [] [] [] [] CHEBI:73998 [] [] r_2274 s_2905[p]: added new MNXMID MNXM36530 into model | MNXM36530 is linked to current ChEBIID CHEBI:76453 as external resource [] [] [] +s_2907[p] [] MNXM36558 [] [] [] [] CHEBI:87781 [] [] r_2259 s_2907[p]: added new MNXMID MNXM36558 into model [] [] [] [] +s_2908[p] [] [] [] [] [] [] [] [] CHEBI:88087 r_2260; r_2277 s_2908[p]: alternative metChEBID CHEBI:88087 found [] [] "| Alternative ChEBIID CHEBI:88087 ((3S,7Z)-3-hydroxyhexadecenoyl-CoA, an isomer) is noted down in model.metNotes " [] +s_2911[p] [] MNXM149457 [] [] [] [] CHEBI:75070 [] [] r_2263 s_2911[p]: added new MNXMID MNXM149457 into model | MNXM149457 is linked to current ChEBIID CHEBI:87781 as external resource [] [] [] +s_2920[p] [] [] [] [] [] [] CHEBI:53152 [] CHEBI:88090 r_2277; r_2289 s_2920[p]: alternative metChEBID CHEBI:88090 found [] [] "| Wrong ChEBIID CHEBI:53152 (hexadecenoyl-CoA), alternative ChEBIID CHEBI:88090 ((7Z)-3-oxohexadecenoyl-CoA, an isomer) is noted down in model.metNotes " [] +s_2921[p] [] [] [] [] [] [] [] [] CHEBI:88080 r_2278; r_2290 s_2921[p]: alternative metChEBID CHEBI:88080 found [] [] "| Alternative ChEBIID CHEBI:88080 ((5Z)-3-oxotetradecenoyl-CoA, an isomer) is noted down in model.metNotes " [] +s_2923[p] [] [] [] [] [] [] CHEBI:78146 [] CHEBI:76896 r_2292 s_2923[p]: alternative metChEBID CHEBI:76896 found [] [] "| Wrong ChEBIID CHEBI:78146 (trans-9-octadecenoyl-CoA), alternative ChEBIID CHEBI:76896 ((11Z)-3-oxooctadecenoyl-CoA, an isomer) is noted down in model.metNotes " [] +s_2924[p] [] MNXM150996 [] [] [] [] [] CHEBI:88090 [] r_2293 s_2924[p]: added new MNXMID MNXM150996 into model | added new metChEBIID CHEBI:88090 into model | New MNXMID found based on ChEBIID CHEBI:88090 [] | New ChEBIID found based on model.metName 3-oxo-cis-hexadec-7-enoyl-CoA [] +s_2925[p] [] MNXM147795 [] [] [] [] [] CHEBI:88080 [] r_2294 s_2925[p]: added new MNXMID MNXM147795 into model | added new metChEBIID CHEBI:88080 into model | New MNXMID found based on ChEBIID CHEBI:88080 [] | New ChEBIID found based on model.metName 3-oxo-cis-tetradec-5-enoyl-CoA [] +s_2926[p] [] MNXM164218 [] [] [] [] [] [] [] r_2295 | metFormula in MNX database (C31H48N7O17P3S) with metCharge -4 is a conjugate base of cis-dec-3-enoyl-CoA (C31H52N7O17P3S) | New MNXMID found based on metName cis-dec-3-enoyl-CoA [] [] [] +s_2927[p] [] MNXM3949 [] [] [] [] CHEBI:27989 [] [] r_2294 s_2927[p]: added new MNXMID MNXM3949 into model | New MNXMID found based on ChEBIID CHEBI:27989 [] [] [] +s_2930[p] [] MNXM9966 [] [] [] [] CHEBI:72001 [] [] r_2302 "| metFormula in MNX database (C35H54N7O17P3S) with metCharge -4 is a conjugate base of trans-3,cis-5-tetradecadienoyl-CoA (C35H58N7O17P3S)" | New MNXMID found based on ChEBIID CHEBI:72001 [] [] [] +s_2931[p] [] MNXM7189 [] [] [] [] CHEBI:88083 [] [] r_2300 | metFormula in MNX database (C35H56N7O17P3S) with metCharge -4 is a conjugate base of trans-tetradec-3-enoyl-CoA (C35H60N7O17P3S) | New MNXMID found based on ChEBIID CHEBI:88083 [] [] [] +s_2933[p] [] MNXM147629 [] [] [] [] CHEBI:88084 [] [] r_2302 "| metFormula in MNX database (C35H54N7O17P3S) with metCharge -4 is a conjugate base of trans-2,trans-4-tetradecadienoyl-CoA (C35H58N7O17P3S)" | New MNXMID found based on ChEBIID CHEBI:88084 [] [] [] +s_2936[erm] [] MNXM66496 [] [] [] [] CHEBI:75071 [] [] r_2309 s_2936[erm]: added new MNXMID MNXM66496 into model | MNXM66496 is linked to current ChEBIID CHEBI:75070 as external resource [] [] [] +s_2937[erm] [] MNXM32950 [] [] [] [] CHEBI:74850 [] [] r_2336 "| Added new MNXMID MNXM32950 into model, for metabolites with metName 1-acyl-sn-glycerol 3-phosphate (18:0) in all compartments" | metFormula in MNX database (C21H41O7P) with metCharge -2 is a conjugate base of 1-acyl-sn-glycerol 3-phosphate (18:0) (C21H43O7P) [] [] [] +s_2938[erm] [] MNXM32960 [] [] [] [] CHEBI:62837 [] [] r_2338 "| Added new MNXMID MNXM32960 into model, for metabolites with metName 1-acyl-sn-glycerol 3-phosphate (18:1) in all compartments" | metFormula in MNX database (C21H39O7P) with metCharge -2 is a conjugate base of 1-acyl-sn-glycerol 3-phosphate (18:1) (C21H41O7P) [] [] [] +s_2941[erm] [] [] [] [] [] [] CHEBI:74694 Blank CHEBI:74694 r_2313 s_2941[erm]: alternative metChEBID CHEBI:74694 found [] [] | ChEBIID is removed as it does not correspond to metabolite in model [] +s_2954[erm] [] MNXM66470 [] [] [] [] CHEBI:73998 [] [] r_2344 "| Added new MNXMID MNXM66470 into model, for metabolites with metName phosphatidate (1-16:0, 2-16:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:73998 [] | metFormula of ChEBIID CHEBI:73998 (C35H65O7P) with metCharge -2 is a conjugate base of metFormula in model "| metFormula in model matches LMGP10010911, a conjugate acid of C35H65O8P" +s_2956[erm] [] MNXM66504 [] [] [] [] CHEBI:75071 [] [] r_2346 "| Added new MNXMID MNXM66470 into model, for metabolites with metName phosphatidate (1-16:1, 2-16:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:75071 [] [] [] +s_2957[erm] [] MNXM66509 [] [] [] [] [] [] [] r_2347 "| Added new MNXMID MNXM66509 into model, for metabolites with metName phosphatidate (1-16:1, 2-16:1) in all compartments" | New MNXMID found based on LMGP10010903 [] [] "| metFormula in model matches LMGP10010903, a conjugate acid of C37H69O8P" +s_2958[erm] [] MNXM66631 [] [] [] [] CHEBI:75073 [] [] r_2348 "| Added new MNXMID MNXM66631 into model, for metabolites with metName phosphatidate (1-18:0, 2-16:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:75073 [] [] [] +s_2959[erm] [] MNXM66635 [] [] [] [] CHEBI:74847 [] [] r_2349 "| Added new MNXMID MNXM66635 into model, for metabolites with metName phosphatidate (1-18:0, 2-18:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:74847 [] [] [] +s_2960[erm] [] MNXM66663 [] [] [] [] CHEBI:75074 [] [] r_2350 "| Added new MNXMID MNXM66663 into model, for metabolites with metName phosphatidate (1-18:1, 2-16:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:75074 [] [] [] +s_2961[erm] [] MNXM51075 [] [] [] [] CHEBI:83775 [] [] r_2351 "| Added new MNXMID MNXM51075 into model, for metabolites with metName phosphatidate (1-18:1, 2-18:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:83775 [] [] [] +s_2967[erm] MNXM32182 MNXM49375 [] [] [] [] CHEBI:82929 CHEBI:84394 [] r_2344 "| Changed MNXM32182 to MNXM49375 and change from CHEBI:82929 (diglyceride (1-16:0, 2-16:0)) to CHEBI:84394 (diglyceride (1-16:0, 2-16:1)) in model, for all metabolites with metName diglyceride (1-16:0, 2-16:1)" "| Wrong MNXMID MNXM32182 (diglyceride (1-16:0, 2-16:0)), new MNXMID MNXM49375 (diglyceride (1-16:0, 2-16:1)) found based on LMGL02010010" [] "| Wrong ChEBIID CHEBI:82929 (diglyceride (1-16:0, 2-16:0)), new ChEBIID CHEBI:84394 (diglyceride (1-16:0, 2-16:1)) found based on LMGL02010010" | Reference to LMGL02010010 +s_2969[erm] [] MNXM176611 [] [] [] [] CHEBI:84417 [] [] r_2346 "| Added new MNXMID MNXM17661 into model, for metabolites with metName diglyceride (1-16:1, 2-16:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:84417 [] [] [] +s_2970[erm] [] MNXM49417 [] [] [] [] CHEBI:88500 [] [] r_2347 "| Added new MNXMID MNXM49417 into model, for metabolites with metName diglyceride (1-16:1, 2-18:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:88500 [] [] [] +s_2971[erm] [] MNXM49511 [] [] [] [] CHEBI:88527 [] [] r_2348 "| Added new MNXMID MNXM49511 into model, for metabolites with metName diglyceride (1-18:0, 2-16:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:88527 [] [] [] +s_2972[erm] [] MNXM49514 [] [] [] [] CHEBI:75468 [] [] r_2349 "| Added new MNXMID MNXM49514 into model, for metabolites with metName diglyceride (1-18:0, 2-18:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:75468 [] [] [] +s_2973[erm] [] MNXM49575 [] [] [] [] CHEBI:89229 [] [] r_2350 "| Added new MNXMID MNXM49575 into model, for metabolites with metName diglyceride (1-18:1, 2-16:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:89229 [] [] [] +s_2974[erm] [] MNXM9533 [] [] [] [] CHEBI:52333 [] [] r_2351 "| Added new MNXMID MNXM9533 into model, for metabolites with metName diglyceride (1-18:1, 2-18:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:52333 [] [] [] +s_3098[mm] [] MNXM4508 [] [] [] [] CHEBI:104012 [] [] r_2538 "| metFormula in MNX database (C44H75N3O15P2) with metCharge -2 is a conjugate base of CDP-diacylglycerol (1-16:0, 2-16:1) (C44H77N3O15P2)" | New MNXMID found based on ChEBIID CHEBI:104012 [] [] [] +s_3109[erm] [] MNXM78605 [] [] [] [] CHEBI:89824 [] [] r_2446 s_3109[erm]: added new MNXMID MNXM78605 into model | New MNXMID found based on ChEBIID CHEBI:89824 [] [] [] +s_3110[erm] [] MNXM78637 [] [] [] [] [] [] [] r_2447 s_3110[erm]: added new MNXMID MNXM78637 into model | New MNXMID found based on LMGP03010964 [] [] | Reference to LMGP03010964 +s_3111[erm] [] MNXM78765 [] [] [] [] CHEBI:90036 [] [] r_2448 s_3111[erm]: added new MNXMID MNXM78765 into model | New MNXMID found based on ChEBIID CHEBI:90036 [] [] [] +s_3112[erm] [] MNXM78797 [] [] [] [] CHEBI:75101 [] [] r_2449 s_3112[erm]: added new MNXMID MNXM78797 into model | New MNXMID found based on ChEBIID CHEBI:75101 [] [] [] +s_3113[erm] [] MNXM32501 [] [] [] [] CHEBI:134541 CHEBI:34086 [] r_2450 s_3113[erm]: changed MNXMID [] to MNXM32501 | changed metChEBIID CHEBI:134541 to CHEBI:34086 | New MNXMID found based on LMGP03010024 and ChEBIID CHEBI:34086 [] | New ChEBIID contains external links to more databases e.g. LMGP03010024 | Reference to LMGP03010024 +s_3114[erm] [] MNXM78642 [] [] [] [] CHEBI:90032 [] [] r_2451 s_3114[erm]: added new MNXMID MNXM78642 into model | New MNXMID found based on ChEBIID CHEBI:90032 [] [] [] +s_3115[erm] [] MNXM32529 [] [] [] [] CHEBI:90433 CHEBI:79096 [] r_2452 s_3115[erm]: changed MNXMID [] to MNXM32529 | changed metChEBIID CHEBI:90433 to CHEBI:79096 | New MNXMID found based on LMGP03010025 and ChEBIID CHEBI:79096 [] | New ChEBIID contains external links to more databases e.g. LMGP03010025 | Reference to LMGP03010025 +s_3116[erm] [] MNXM32173 [] [] [] [] CHEBI:60568 [] [] r_2453 s_3116[erm]: added new MNXMID MNXM32173 into model | New MNXMID found based on ChEBIID CHEBI:60568 [] [] [] +s_3120[erm] [] MNXM75665 [] [] [] [] CHEBI:88557 [] [] r_2462 "| metFormula in MNX database (C43H80O13P) with metCharge -1 is a conjugate base of 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) (C43H81O13P)" | New MNXMID found based on ChEBIID CHEBI:88557 [] [] [] +s_3124[erm] [] MNXM75671 [] [] [] [] CHEBI:77346 [] [] r_2463 "| metFormula in MNX database (C45H84O13P) with metCharge -1 is a conjugate base of 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) (C45H85O13P)" | New MNXMID found based on ChEBIID CHEBI:77346 [] [] [] +s_3126[erm] [] [] [] [] [] [] [] CHEBI:138108 [] r_2462 s_3126[erm]: added new metChEBIID CHEBI:138108 into model [] [] | New ChEBIID found based on model.metName sn-2-acyl-1-lysophosphatidylinositol (16:1) - a type of LPI | Reference to LMGP06050009 to match model.metNames with metabolite name in ChEBIID +s_3127[erm] [] [] [] [] [] [] [] [] CHEBI:90456 r_2463 s_3127[erm]: alternative metChEBID CHEBI:90456 found [] [] | Alternative ChEBIID found based on model.metName sn-2-acyl-1-lysophosphatidylinositol (18:1) - a type of LPI [] +s_3224[mm] [] MNXM725269 [] [] [] [] [] [] [] r_2540 s_3224[mm]: added new MNXMID MNXM725269 into model | New MNXMID found based on LMGP05010001 [] [] | Verified via reference to LMGP05010001 +s_3234[mm] [] MNXM120766 [] [] [] [] [] [] [] r_2548 s_3234[mm]: added new MNXMID MNXM120766 into model "| New MNXMID found based on metName cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1)" [] [] | Reference to PubChem CID 131766957 +s_3235[mm] [] MNXM120775 [] [] [] [] [] [] [] r_2549 s_3235[mm]: added new MNXMID MNXM120775 into model "| New MNXMID found based on metName cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1) " [] [] | Reference to PubChem CID 131766970 +s_3236[mm] [] MNXM120785 [] [] [] [] [] [] [] r_2550 s_3236[mm]: added new MNXMID MNXM120785 into model "| New MNXMID found based on metName cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1)" [] [] | Reference to PubChem CID 131766967 +s_3237[mm] [] MNXM120792 [] [] [] [] [] [] [] r_2551 s_3237[mm]: added new MNXMID MNXM120792 into model "| New MNXMID found based on metName cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1)" [] [] | Reference to PubChem CID 131766983 +s_3238[mm] [] MNXM120768 [] [] [] [] [] [] [] r_2552 s_3238[mm]: added new MNXMID MNXM120768 into model "| New MNXMID found based on metName cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1)" [] [] | Reference to PubChem CID 131766959 +s_3239[mm] [] MNXM120778 [] [] [] [] [] [] [] r_2553 s_3239[mm]: added new MNXMID MNXM120778 into model "| New MNXMID found based on metName cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1)" [] [] | Reference to PubChem CID 131766972 +s_3241[mm] [] MNXM4501 MNXM121235 [] [] [] CHEBI:104873 [] [] r_2555 s_3241[mm]: added new MNXMID MNXM4501 into model | alternative MNXMID MNXM121235 found "| New MNXMID found based on ChEBIID CHEBI:104873 | Alternative MNXMID found based on metName cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)" [] [] [] +s_3243[mm] [] MNXM121254 [] [] [] [] [] [] [] r_2557 s_3243[mm]: added new MNXMID MNXM121254 into model "| New MNXMID found based on metName cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)" [] [] | Reference to PubChem CID 131767800 +s_3245[mm] [] MNXM121237 [] [] [] [] [] [] [] r_2259 s_3245[mm]: added new MNXMID MNXM121237 into model "| New MNXMID found based on metName cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)" [] [] | Reference to PubChem CID 131767782 +s_3259[mm] [] MNXM120922 [] [] [] [] [] [] [] r_2573 s_3259[mm]: added new MNXMID MNXM120922 into model "| New MNXMID found based on metName cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1)" [] [] | Reference to PubChem CID 131767064 +s_3261[mm] [] MNXM120940 [] [] [] [] [] [] [] r_2575 s_3261[mm]: added new MNXMID MNXM120940 into model "| New MNXMID found based on metName cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1)" [] [] | Reference to PubChem CID 131767077 +s_3263[mm] [] MNXM120924 [] [] [] [] [] [] [] r_2577 s_3263[mm]: added new MNXMID MNXM120924 into model "| New MNXMID found based on metName cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1)" [] [] | Reference to PubChem CID 131767066 +s_3297[mm] [] MNXM32510 [] [] [] [] [] CHEBI:72998 [] r_2812 "| Added new MNXMID MNXM32510 and new metChEBIID CHEBI:72998 into model, for metabolites with metName 1-acylglycerophosphocholine (16:0) in all compartments" | New MNXMID found based on LMGP01050018 [] | New ChEBIID found based on MNXM32510 | Reference to LMGP01050018 +s_3299[mm] [] MNXM32519 [] [] [] [] [] CHEBI:73851 [] r_2814 "| Added new MNXMID MNXM32519 and new metChEBIID CHEBI:73851 into model, for metabolites with metName 1-acylglycerophosphocholine (16:1) in all compartments" | New MNXMID found based on LMGP01050022 [] | New ChEBIID found based on MNXM32519 | Reference to LMGP01050022 +s_3301[mm] [] MNXM32545 [] [] [] [] [] CHEBI:73858 [] r_2816 "| Added new MNXMID MNXM32545 and new metChEBIID CHEBI:73858 into model, for metabolites with metName 1-acylglycerophosphocholine (18:0) in all compartments" | New MNXMID found based on LMGP01050026 [] | New ChEBIID found based on MNXM32545 | Reference to LMGP01050026 +s_3303[mm] [] MNXM13872 [] [] [] [] [] CHEBI:28610 [] r_2818 "| Added new MNXMID MNXM13872 and new metChEBIID CHEBI:28610 into model, for metabolites with metName 1-acylglycerophosphocholine (18:1) in all compartments" | New MNXMID found based on LMGP01050032 [] | New ChEBIID found based on MNXM13872 | Reference to LMGP01050032 +s_3358[gm] [] MNXM75492 [] [] [] [] CHEBI:88396 [] [] r_3348; r_3428 "| Added new MNXMID MNXM75492 into model for metabolites with metName 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:49031 [] [] [] +s_3368[gm] [] MNXM75499 [] C13888 [] [] CHEBI:73215 [] [] r_3448 "| Added new MNXMID MNXM75499 into model, for metabolites with metName 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) in all compartments" | New MNXMID found based on ChEBIID CHEBI:73215 [] [] [] +s_3452[ce] [] MNXM69377 [] [] [] [] CHEBI:134637 CHEBI:83717 [] r_3105 "| Added new MNXMID MNXM69377 into model and changed CHEBI:134637 to CHEBI:83717, for metabolites with metName phosphatidylcholine (1-16:1, 2-16:1) in all compartments" | New MNXMID found based on LMGP01010684 [] "| New ChEBIID CHEBI:83717 found based on LMGP01010744, same metFormula as CHEBI:134637 but new ChEBIID CHEBI:83717 corresponds to MNXMID with correct metFormula" | Verified via reference to LMGP01010684 +s_3454[ce] [] MNXM69528 [] [] [] [] CHEBI:89972 CHEBI:86097 [] r_3106 "| Added new MNXMID MNXM69528 into model and changed CHEBI:89972 to CHEBI:86097, for metabolites with metName phosphatidylcholine (1-18:0, 2-16:1) in all compartments" | New MNXMID found based on LMGP01010744 [] "| Wrong ChEBIID CHEBI:89972 (PC(P-18:0/16:1(9Z))), new ChEBIID CHEBI:86097 (PC(18:0/16:1(9Z))) found based on LMGP01010744" | Verified via reference to LMGP01010744 +s_3456[ce] [] MNXM69658 [] [] [] [] CHEBI:89506 CHEBI:86100 [] r_3107 "| Added new MNXMID MNXM69658 into model and changed CHEBI:89506 to CHEBI:86100, for metabolites with metName phosphatidylcholine (1-18:1, 2-16:1) in all compartments" | New MNXMID found based on LMGP01010887 [] "| Wrong ChEBIID CHEBI:89506 (PC(P-18:1(9Z)/16:1(9Z))), new ChEBIID CHEBI:86100 (PC(18:1(9Z)/16:1(9Z))) found based on LMGP01010887" | Verified via reference to LMGP01010887 +s_3460[ce] [] MNXM69383 [] [] [] [] CHEBI:89668 CHEBI:84811 [] r_3109 "| Added new MNXMID MNXM69383 into model and changed CHEBI:89668 to CHEBI:84811, for metabolites with metName phosphatidylcholine (1-16:1, 2-18:1) in all compartments" | New MNXMID found based on LMGP01010688 [] "| Wrong ChEBIID CHEBI:89668 (PC(16:1(9Z)/P-18:1(9Z))), new ChEBIID CHEBI:84811 (PC(16:1(9Z)/18:1(9Z))) found based on LMGP01010688" | Verified via reference to LMGP01010688 +s_3461[ce] [] MNXM32526 [] [] [] [] CHEBI:89679 CHEBI:75034 [] r_3110 "| Added new MNXMID MNXM32526 into model and changed CHEBI:89679 to CHEBI:75034, for metabolites with metName phosphatidylcholine (1-18:0, 2-18:1) in all compartments" | New MNXMID found based on LMGP01010761 [] "| Wrong ChEBIID CHEBI:89679 PC(18:0/P-18:1(9Z)), new ChEBIID CHEBI:75034 (PC(18:0/18:1(9Z))) found based on LMGP01010761" | Verified via reference to LMGP01010761 +s_3462[ce] [] MNXM8549 [] [] [] [] CHEBI:89504 CHEBI:74669 [] r_3111 "| Added new MNXMID MNXM8549 into model and changed CHEBI:89504 to CHEBI:74669, for metabolites with metName phosphatidylcholine (1-18:1, 2-18:1) in all compartments" | New MNXMID found based on LMGP01010890 [] "| Wrong ChEBIID CHEBI:89504 PC(P-18:1(9Z)/18:1(9Z)), new ChEBIID CHEBI:74669 (PC(18:1(9Z)/18:1(9Z))) found based on LMGP01010890" | Verified via reference to LMGP01010890 +s_3479[ce] [] MNXM78597 [] [] [] [] [] [] [] r_3058 s_3479[ce]: added new MNXMID MNXM78597 into model | New MNXMID found via reference to LMGP03050002 [] [] | Reference to LMGP03050002 +s_3481[ce] [] MNXM78629 [] [] [] [] [] [] [] r_3059 s_3481[ce]: added new MNXMID MNXM78629 into model | New MNXMID found via reference to LMGP03050010 [] [] | Reference to LMGP03050010 +s_3483[ce] [] MNXM78757 [] [] [] [] [] CHEBI:85403 [] r_3060 s_3483[ce]: added new MNXMID MNXM78757 into model | New MNXMID found via reference to LMGP03050006 [] | New ChEBIID found via reference to LMGP03050006 | Reference to LMGP03050006 +s_3485[ce] [] MNXM32944 [] [] [] [] [] CHEBI:52649 [] r_3061 s_3485[ce]: added new MNXMID MNXM32944 into model | New MNXMID found via reference to LMGP03050001 [] | New ChEBIID found via reference to LMGP03050001 | Reference to LMGP03050001 +s_3774[er] [] MNXM6479 [] [] G00011 [] [] [] [] r_4271 s_3774[er]: added new MNXMID MNXM6479 into model [] |G00011 not added into model due to SPML formatting issue [] [] +s_3807[c] MNXM2246 MNXM722780 MNXM2246 C15999 [] [] [] [] [] r_4186 "s_3807[c]: changed MNXM2246 to MNXM722780, add alternative MNXMID MNXM2246 into model.metNotes" | MNXM97616 is linked to current KEGGID C15999 [] [] [] +s_3810[c] MNXM964 MNXM722719 [] C01879 [] [] CHEBI:58402 [] [] r_4188 s_3810[c]: changed MNXMID MNXM964 to MNXM722719 | MNXMID MNXM964 is deprecated in MNX database [] [] [] +s_3847[c] MNXM89592 MNXM129 [] C00072 [] [] CHEBI:38290 [] [] r_4208 s_3847[c]: changed MNXMID MNXM89592 to MNXM129 | MNXMID MNXM89592 is not found in MNX database | MNXMID MNXM129 found via metKEGGID C00072 and metChEBIID CHEBI:38290 [] [] [] +s_3852[c] MNXM116 MNXM722712 [] C00117 [] [] CHEBI:58273 [] [] r_4211 s_3852[c]: changed MNXMID MNXM116 to MNXM722712 | MNXMID MNXM116 is deprecated in MNX database [] [] [] +s_3887[er] [] MNXM9308 [] [] G00008 [] [] [] [] r_4253 s_3887[er]: added new MNXMID MNXM9308 into model [] |G00008 not added into model due to SPML formatting issue [] [] +s_3888[er] [] MNXM2370 [] [] C00621 [] CHEBI:57497 [] [] r_4250 "s_3888[er]: add MNXMID MNXM2370, add metKEGGID C00621" [] [] [] [] +s_3908[m] MNXM201 [] [] C00269 [] [] CHEBI:58332 CHEBI:17962 [] r_4251 | metFormula in MNX database (C14H17N3O15P2R2) with metCharge -2 is a conjugate base of CDP-diacylglycerol (C14H19N3O15P2R2) [] [] "| Changed from CHEBI:58332 to CHEBI:17962 (conjugate acid of CHEBI:58332) in model, for all metabolites with metName CDP-diacylglycerol" [] +s_3910[c] MNXM37826 MNXM722955 [] C20784 [] [] CHEBI:134399 [] [] r_4252 s_3910[c]: changed MNXMID MNXM37826 to MNXM722955 | MNXMID MNXM37826 is deprecated in MNX database [] [] [] +s_3912[er] [] MNXM9258 [] [] G10599 [] [] [] [] r_4253 s_3912[er]: added new MNXMID MNXM9258 into model [] |G10599 not added into model due to SPML formatting issue [] [] +s_3912[er] [] MNXM9258 [] [] G10599 [] [] [] [] r_4321 s_3912[er]: added new MNXMID MNXM9258 into model [] |G10599 not added into model due to SPML formatting issue [] [] +s_3932[er] [] MNXM9328 [] [] G00012 [] [] [] [] r_4271 s_3932[er]: added new MNXMID MNXM9328 into model [] |G00012 not added into model due to SPML formatting issue [] [] +s_3942[p] [] MNXM4425 [] C19967 [] [] [] [] [] r_4279 s_3942[p]: added new MNXMID MNXM4425 into model [] [] [] [] +s_3943[p] [] MNXM2497 [] C19968 [] [] [] [] [] r_4279 s_3943[p]: added new MNXMID MNXM2497 into model [] [] [] [] +s_3993[er] [] MNXM9262 [] [] G10595 [] [] [] [] r_4313 s_3993[er]: added new MNXMID MNXM9262 into model [] |G10595 not added into model due to SPML formatting issue [] [] +s_3994[er] [] MNXM9265 [] [] G10596 [] [] [] [] r_4313 s_3994[er]: added new MNXMID MNXM9265 into model [] |G10596 not added into model due to SPML formatting issue [] [] +s_3996[er] [] MNXM31425 [] [] G00007 [] [] [] [] r_4320 s_3996[er]: added new MNXMID MNXM31425 into model [] |G00007 not added into model due to SPML formatting issue [] [] +s_4001[er] [] MNXM9336 [] [] G10598 [] [] [] [] r_4320 s_4001[er]: added new MNXMID MNXM9336 into model [] |G10598 not added into model due to SPML formatting issue [] [] +s_4002[er] [] MNXM7903 [] [] G00149 [] [] [] [] r_4322 s_4002[er]: added new MNXMID MNXM7903 into model | MNXM7903 is linked to KEGGID G00149 as external resource |G00149 not added into model due to SPML formatting issue [] [] +s_4003[er] [] MNXM9266 [] [] G00140 [] [] [] [] r_4322 s_4003[er]: added new MNXMID MNXM9266 into model | MNXM9266 is linked to KEGGID G00140 as external resource |G00140 not added into model due to SPML formatting issue [] [] +s_4122[c] MNXM61741 MNXM724960 [] [] [] [] CHEBI:320061 [] [] r_4390 s_4122[c]: changed MNXMID MNXM61741 to MNXM724960 | MNXMID MNXM61741 is deprecated in MNX database [] [] [] +% diff --git a/ComplementaryData/physiology/biomassComposition_Cofactor_Ion.tsv b/ComplementaryData/physiology/biomassComposition_Cofactor_Ion.tsv index 6a948332..31735b48 100644 --- a/ComplementaryData/physiology/biomassComposition_Cofactor_Ion.tsv +++ b/ComplementaryData/physiology/biomassComposition_Cofactor_Ion.tsv @@ -1,21 +1,21 @@ -model_id name abundance_mmol/gDW MW_g/mol group reference -s_3880[c] Ca(2+) 2.17E-04 40.08 ion DOI: 10.22161/ijeab/2.2.2 -s_3778[c] chloride 1.29E-03 35.45 ion DOI: 10.3103/S106836741702015X -s_4019[c] Cu2(+) 6.59E-04 63.55 ion DOI: 10.22161/ijeab/2.2.2 -s_0924[c] iron(2+) 3.04E-05 55.84 ion DOI: 10.22161/ijeab/2.2.2 -s_3801[c] Mn(2+) 2.73E-03 54.94 ion DOI: 10.22161/ijeab/2.2.2 -s_3822[c] Zn(2+) 7.48E-04 65.39 ion DOI: 10.22161/ijeab/2.2.2 -s_1373[c] potassium 3.63E-03 39.1 ion DOI: 10.22161/ijeab/2.2.2 -s_1437[c] sodium 3.97E-03 22.99 ion DOI: 10.22161/ijeab/2.2.2 -s_4013[c] Mg(2+) 0.001242543 24.3 ion DOI: 10.22161/ijeab/2.2.2 -s_1467[c] sulphate 0.02 96.06 ion Forster2003 -s_1203[c] NADH 1.5E-04 663.43 cofactor DOI: 10.1016/j.ymben.2013.11.005; Supplementary file -s_1198[c] NAD 2.65E-03 662.43 cofactor DOI: 10.1016/j.ymben.2013.11.005; Supplementary file -s_1212[c] NADPH 2.7E-03 745.4209 cofactor DOI: 10.1016/j.ymben.2013.11.005; Supplementary file -s_1207[c] NADP(+) 5.7E-04 744.4129 cofactor DOI: 10.1016/j.ymben.2013.11.005; Supplementary file -s_0529[c] coenzyme A 1.90E-04 767.5341 cofactor DOI: 10.1016/j.ymben.2013.11.005; Supplementary file -s_1487[c] THF 6.34E-05 445.4292 cofactor DOI: 10.1021/jf048083g -s_1475[c] TDP 0.0000012 425.3144 cofactor DOI:10.1002/jib.293; Figure 6B -s_0687[c] FAD 0.00001 785.5497 cofactor DOI: 10.1002/yea.1897 -s_1405[c] riboflavin 0.00099 376.36 cofactor Forster2003 -s_3714[c] heme a 0.000001 852.83 cofactor Forster2003 +model_id name abundance_mmol/gDW MW_g/mol group reference +s_3880[c] Ca(2+) 2.17E-04 40.08 ion DOI: 10.22161/ijeab/2.2.2 +s_3778[c] chloride 1.29E-03 35.45 ion DOI: 10.3103/S106836741702015X +s_4019[c] Cu2(+) 6.59E-04 63.55 ion DOI: 10.22161/ijeab/2.2.2 +s_0924[c] iron(2+) 3.04E-05 55.84 ion DOI: 10.22161/ijeab/2.2.2 +s_3801[c] Mn(2+) 2.73E-03 54.94 ion DOI: 10.22161/ijeab/2.2.2 +s_3822[c] Zn(2+) 7.48E-04 65.39 ion DOI: 10.22161/ijeab/2.2.2 +s_1373[c] potassium 3.63E-03 39.1 ion DOI: 10.22161/ijeab/2.2.2 +s_1437[c] sodium 3.97E-03 22.99 ion DOI: 10.22161/ijeab/2.2.2 +s_4013[c] Mg(2+) 0.001242543 24.3 ion DOI: 10.22161/ijeab/2.2.2 +s_1467[c] sulphate 0.02 96.06 ion Forster2003 +s_1203[c] NADH 1.5E-04 663.43 cofactor DOI: 10.1016/j.ymben.2013.11.005; Supplementary file +s_1198[c] NAD 2.65E-03 662.43 cofactor DOI: 10.1016/j.ymben.2013.11.005; Supplementary file +s_1212[c] NADPH 2.7E-03 745.4209 cofactor DOI: 10.1016/j.ymben.2013.11.005; Supplementary file +s_1207[c] NADP(+) 5.7E-04 744.4129 cofactor DOI: 10.1016/j.ymben.2013.11.005; Supplementary file +s_0529[c] coenzyme A 1.90E-04 767.5341 cofactor DOI: 10.1016/j.ymben.2013.11.005; Supplementary file +s_1487[c] THF 6.34E-05 445.4292 cofactor DOI: 10.1021/jf048083g +s_1475[c] TDP 0.0000012 425.3144 cofactor DOI:10.1002/jib.293; Figure 6B +s_0687[c] FAD 0.00001 785.5497 cofactor DOI: 10.1002/yea.1897 +s_1405[c] riboflavin 0.00099 376.36 cofactor Forster2003 +s_3714[c] heme a 0.000001 852.83 cofactor Forster2003 diff --git a/ComplementaryScripts/__init__.py b/ComplementaryScripts/__init__.py new file mode 100644 index 00000000..e69de29b diff --git a/ComplementaryScripts/io.py b/ComplementaryScripts/io.py new file mode 100644 index 00000000..27b31c9a --- /dev/null +++ b/ComplementaryScripts/io.py @@ -0,0 +1,111 @@ +""" +Functions for importing and exporting the yeast model using COBRA from anywhere in the repo. +""" + +import csv +from cobra.io import read_sbml_model, write_sbml_model +from copy import copy +from dotenv import find_dotenv +from os.path import dirname + +# find .env + define paths: +dotenv_path = find_dotenv() +REPO_PATH = dirname(dotenv_path) +MODEL_PATH = f"{REPO_PATH}/ModelFiles/xml/yeastGEM.xml" + +def read_yeast_model(make_bigg_compliant=False): + """Reads the SBML file of the yeast model using COBRA. + + Parameters + ---------- + make_bigg_compliant : bool, optional + Whether the model should be initialized with BiGG compliance or not. + If false, the original ids/names/compartments will be used instead. + + Returns + ------- + cobra.core.Model + """ + + # Load model: + model = read_sbml_model(MODEL_PATH) + + # Check if already BiGG compliant: + is_bigg_compliant = "x" in model.compartments + + # Convert to BiGG compliant if not already: + if not is_bigg_compliant and make_bigg_compliant: + # Load met/rxn dictionaries: + def load_bigg_dict(bigg_file_path): + bigg_dict = {} + with open(bigg_file_path) as bigg_file: + bigg_reader = csv.reader(bigg_file, delimiter=',') + for row in bigg_reader: + bigg_dict[row[0]] = row[1] + return bigg_dict + data_path = f"{REPO_PATH}/ComplementaryData/databases" + met_bigg_dict = load_bigg_dict(f"{data_path}/BiGGmetDictionary_newIDs.csv") + rxn_bigg_dict = load_bigg_dict(f"{data_path}/BiGGrxnDictionary_newIDs.csv") + + # Function for adding unique ids to the model: + def add_new_id(model_element, new_id): + original_id = copy(new_id) + id_assigned = False + copy_number = 1 + while not id_assigned: + try: + if hasattr(model_element, "compartment"): # metabolites + model_element.id = f"{new_id}_{model_element.compartment}" + else: # reactions + model_element.id = new_id + id_assigned = True + except ValueError: + new_id = f"{original_id}_copy{str(copy_number)}" + copy_number += 1 + + # Metabolite changes: + comp_dic = {"er":"r", "erm":"rm", "p":"x"} + for met in model.metabolites: + # Save original id in notes: + met.notes["Original ID"] = met.id + # Change name to not include compartment at the end: + met.name = met.name.replace(f" [{model.compartments[met.compartment]}]", "") + # Change compartment info: + if met.compartment in comp_dic: + met.compartment = comp_dic[met.compartment] + # Update id with BiGG information: + if "bigg.metabolite" in met.annotation: + add_new_id(met, met.annotation['bigg.metabolite']) + elif met.id in met_bigg_dict: + add_new_id(met, met_bigg_dict[met.id]) + else: + met.id = met.id.replace(f"[{met.compartment}]", f"_{met.compartment}") + + # Compartment changes: + comps = model.compartments + comps["r"] = "endoplasmic reticulum" + comps["rm"] = "endoplasmic reticulum membrane" + comps["x"] = "peroxisome" + model.compartments = comps + + # Reaction changes: + for rxn in model.reactions: + # Update id with BiGG information: + if "bigg.reaction" in rxn.annotation: + rxn.notes["Original ID"] = rxn.id + add_new_id(rxn, rxn.annotation['bigg.reaction']) + elif rxn.id in rxn_bigg_dict: + rxn.notes["Original ID"] = rxn.id + add_new_id(rxn, rxn_bigg_dict[rxn.id]) + + return model + +def write_yeast_model(model): + """Writes the SBML file of the yeast model using COBRA. + + Parameters + ---------- + model : cobra.core.Model + Yeast model to be written + """ + write_sbml_model(model, MODEL_PATH) diff --git a/ComplementaryScripts/loadYeastModel.py b/ComplementaryScripts/loadYeastModel.py deleted file mode 100644 index 62bd1d4d..00000000 --- a/ComplementaryScripts/loadYeastModel.py +++ /dev/null @@ -1,11 +0,0 @@ -# -*- coding: utf-8 -*- -import cobra - -# Load model -model = cobra.io.read_sbml_model('../ModelFiles/xml/yeastGEM.xml') - -# Correct metabolite ids: -for met in model.metabolites: - met.id = met.id.replace('__91__', '_') - met.id = met.id.replace('__93__', '') - diff --git a/ComplementaryScripts/missingFields/BiGGidsCompliance.ipynb b/ComplementaryScripts/missingFields/BiGGidsCompliance.ipynb new file mode 100644 index 00000000..c4ebf619 --- /dev/null +++ b/ComplementaryScripts/missingFields/BiGGidsCompliance.ipynb @@ -0,0 +1,405 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Curation of BiGG ids\n", + "\n", + "Notebook for correcting misc. issues with BiGG dictionaries provided by @snmendoz in PR #188.\n", + "\n", + "## 1. Splitting list into separate lists\n", + "\n", + "We will start by splitting the original met/reaction files into 2 separates based on if they belong or not to BiGG:" + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "metadata": {}, + "outputs": [], + "source": [ + "# Function for splitting the file in two:\n", + "import csv\n", + "import os\n", + "def split_in_two(old_file_name, bigg_file_name):\n", + " # Create list with BiGG ids:\n", + " with open(bigg_file_name) as bigg_file:\n", + " bigg_list = bigg_file.read().splitlines()\n", + " \n", + " \n", + " # Split file in two:\n", + " in_file_name = old_file_name.replace(\".csv\",\"_in.csv\")\n", + " out_file_name = old_file_name.replace(\".csv\",\"_newIDs.csv\")\n", + " with open(old_file_name) as old_file:\n", + " with open(in_file_name, 'w', newline='') as in_file:\n", + " with open(out_file_name, 'w', newline='') as out_file:\n", + " old_reader = csv.reader(old_file, delimiter=',')\n", + " in_writer = csv.writer(in_file, delimiter=',')\n", + " out_writer = csv.writer(out_file, delimiter=',')\n", + " for row in old_reader:\n", + " if row[1] in bigg_list:\n", + " in_writer.writerow([row[0], row[1]])\n", + " else:\n", + " out_writer.writerow([row[0], row[1]])\n", + "\n", + " # Replace file:\n", + " os.remove(old_file_name)\n", + " os.rename(in_file_name, old_file_name)\n", + "\n", + "# Split both metabolite and reaction files:\n", + "split_in_two('../../ComplementaryData/databases/BiGGmetDictionary.csv', '../../ComplementaryData/databases/mets_already_in_bigg.txt')\n", + "split_in_two('../../ComplementaryData/databases/BiGGrxnDictionary.csv', '../../ComplementaryData/databases/rxns_already_in_bigg.txt')" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## 2. Removing compartment info in met ids\n", + "\n", + "BiGG ids for metabolites don't include any compartment info:" + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "metadata": {}, + "outputs": [], + "source": [ + "# Function for removing compartment info:\n", + "import csv\n", + "import os\n", + "def remove_comp_info(file_name):\n", + " new_file_name = file_name.replace(\".csv\",\"_new.csv\")\n", + " with open(file_name) as old_file:\n", + " with open(new_file_name, 'w', newline='') as new_file:\n", + " bigg_reader = csv.reader(old_file, delimiter=',')\n", + " bigg_writer = csv.writer(new_file, delimiter=',')\n", + " for row in bigg_reader:\n", + " if len(row[1].split(\"[\")) == 2:\n", + " bigg_writer.writerow([row[0], row[1].split(\"[\")[0]])\n", + " else:\n", + " print(\"Warning: \" + row[1])\n", + "\n", + " # Replace file:\n", + " os.remove(file_name)\n", + " os.rename(new_file_name, file_name)\n", + "\n", + "#Remove compartment from both BiGG met files:\n", + "remove_comp_info('../../ComplementaryData/databases/BiGGmetDictionary.csv')\n", + "remove_comp_info('../../ComplementaryData/databases/BiGGmetDictionary_newIds.csv')" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## 3. Lipid ids\n", + "\n", + "We'll redefine these ids to be more systematic with the traditional way of annotating lipids:" + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "{'1-monoglyceride': 'mag', 'diglyceride': 'dag', '1,2-diacylglycerol 3-diphosphate': 'dag2p', 'CDP-diacylglycerol': 'cdpdag', 'triglyceride': 'tag', 'phosphatidate': 'pa', 'phosphatidyl-L-serine': 'ps', '1-acylglycerophosphoserine': 'agps', 'phosphatidylethanolamine': 'pe', 'phosphatidyl-N-methylethanolamine': 'mmpe', 'phosphatidyl-N,N-dimethylethanolamine': 'dmpe', '1-acylglycerophosphoethanolamine': 'agpe', 'phosphatidylcholine': 'pc', '1-acylglycerophosphocholine': 'agpc', 'long-chain base': 'lcb', '1-phosphatidyl-1D-myo-inositol': 'pail', 'sn-2-acyl-1-lysophosphatidylinositol': 'lpi', 'ceramide': 'cer', 'inositol-P-ceramide': 'ipc', 'mannosylinositol phosphorylceramide': 'mipc', 'inositol phosphomannosylinositol phosphoceramide': 'mip2c', '3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate': 'pg1p', 'acylglycerone phosphate': 'agp', 'phosphatidylglycerol': 'pg', 'cardiolipin': 'cl', 'monolysocardiolipin': 'mlcl'}\n" + ] + } + ], + "source": [ + "# Load dictionary with traditional abbreviations:\n", + "import csv\n", + "lip_id_dict = {}\n", + "with open('../../ComplementaryData/databases/lipidAbbreviations.csv') as lip_id_file:\n", + " lip_id_reader = csv.reader(lip_id_file, delimiter=';')\n", + " for row in lip_id_reader:\n", + " lip_id_dict[row[1]] = row[0]\n", + "print(lip_id_dict)\n", + "\n", + "# Create new BiGG ids compliant with lipid standards:\n", + "import cobra\n", + "model = cobra.io.read_sbml_model(\"../../ModelFiles/xml/yeastGEM.xml\")\n", + "file_name = '../../ComplementaryData/databases/BiGGmetDictionary_newIDs.csv'\n", + "new_file_name = file_name.replace(\".csv\",\"_new.csv\")\n", + "with open(file_name) as old_file:\n", + " with open(new_file_name, 'w', newline='') as new_file:\n", + " bigg_reader = csv.reader(old_file, delimiter=',')\n", + " bigg_writer = csv.writer(new_file, delimiter=',')\n", + " for row in bigg_reader:\n", + " met = model.metabolites.get_by_id(row[0])\n", + " new_met_id = row[1]\n", + " for key, proper_id in lip_id_dict.items():\n", + " if met.name.startswith(key):\n", + " new_met_id = met.name.split(\"[\")[0] # remove compartment info\n", + " new_met_id = new_met_id.replace(key, proper_id) # replace name with compliant id\n", + " new_met_id = new_met_id.replace(\"backbone\", \"\") # remove \"backbone\" in generic species\n", + " new_met_id = new_met_id.replace(\"-bisphosphate\", \"bp\") # for pail species\n", + " new_met_id = new_met_id.replace(\"-phosphate\", \"p\") # for pail species\n", + " new_met_id = new_met_id.replace(\"phosphate\", \"p\") # for lcb species\n", + " if proper_id in [\"cer\", \"ipc\", \"mipc\", \"mip2c\"]: # sphingolipids\n", + " new_met_id = new_met_id.replace(\"'\", \"a\") # \"a\" stands for \"apostrophe\"\n", + " new_met_id = new_met_id.replace(\"(C\", \"\") # redundant info\n", + " for index, let in enumerate(\"ABCD\"):\n", + " new_met_id = new_met_id.replace(let, str(index+1)) # use the same standard for all\n", + " for num in \"1234\":\n", + " new_met_id = new_met_id.replace(num + \"-\", \"\") # the order of chains is implied from the string\n", + " for bad_char in \" ():,-\":\n", + " new_met_id = new_met_id.replace(bad_char, \"\") # to stay BiGG compliant\n", + " break\n", + " bigg_writer.writerow([row[0], new_met_id])\n", + "\n", + "# Rename file:\n", + "import os\n", + "os.remove(file_name)\n", + "os.rename(new_file_name, file_name)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# 4. SLIME rxn ids\n", + "\n", + "To be consistent with the newly defined lipid ids:" + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "metadata": {}, + "outputs": [], + "source": [ + "# Load dictionary with ALL BiGG met ids:\n", + "import csv\n", + "def add_to_bigg_dict(file_name, met_bigg_dict):\n", + " with open(file_name) as met_file:\n", + " met_reader = csv.reader(met_file, delimiter=',')\n", + " for row in met_reader:\n", + " met_bigg_dict[row[0]] = row[1]\n", + " return met_bigg_dict\n", + "met_bigg_dict = add_to_bigg_dict('../../ComplementaryData/databases/BiGGmetDictionary.csv', {})\n", + "met_bigg_dict = add_to_bigg_dict('../../ComplementaryData/databases/BiGGmetDictionary_newIDs.csv', met_bigg_dict)" + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "metadata": {}, + "outputs": [], + "source": [ + "# Create new BiGG ids for SLIME rxns compliant with lipid standards:\n", + "import cobra\n", + "model = cobra.io.read_sbml_model(\"../../ModelFiles/xml/yeastGEM.xml\")\n", + "file_name = '../../ComplementaryData/databases/BiGGrxnDictionary_newIDs.csv'\n", + "new_file_name = file_name.replace(\".csv\",\"_new.csv\")\n", + "with open(file_name) as old_file:\n", + " with open(new_file_name, 'w', newline='') as new_file:\n", + " bigg_reader = csv.reader(old_file, delimiter=',')\n", + " bigg_writer = csv.writer(new_file, delimiter=',')\n", + " for row in bigg_reader:\n", + " try:\n", + " rxn = model.reactions.get_by_id(row[0])\n", + " new_rxn_id = row[1]\n", + " if rxn.name.endswith(\"SLIME rxn\"):\n", + " met = rxn.reactants[0]\n", + " new_rxn_id = f\"{met_bigg_dict[met.id]}SLIME{met.compartment}\"\n", + " bigg_writer.writerow([row[0], new_rxn_id])\n", + " except KeyError:\n", + " pass\n", + "\n", + "# Rename file:\n", + "import os\n", + "os.remove(file_name)\n", + "os.rename(new_file_name, file_name)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## 5. Exchange rxns\n", + "\n", + "The standard in BiGG is `EX_id_e`:" + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "metadata": {}, + "outputs": [], + "source": [ + "# Create new BiGG ids for exchange rxns:\n", + "import cobra\n", + "model = cobra.io.read_sbml_model(\"../../ModelFiles/xml/yeastGEM.xml\")\n", + "file_name = '../../ComplementaryData/databases/BiGGrxnDictionary_newIDs.csv'\n", + "new_file_name = file_name.replace(\".csv\",\"_new.csv\")\n", + "with open(file_name) as old_file:\n", + " with open(new_file_name, 'w', newline='') as new_file:\n", + " bigg_reader = csv.reader(old_file, delimiter=',')\n", + " bigg_writer = csv.writer(new_file, delimiter=',')\n", + " for row in bigg_reader:\n", + " try:\n", + " rxn = model.reactions.get_by_id(row[0])\n", + " new_rxn_id = row[1]\n", + " if len(rxn.metabolites) == 1:\n", + " met = list(rxn.metabolites)[0]\n", + " if met.compartment == 'e':\n", + " new_rxn_id = f\"EX_{met_bigg_dict[met.id]}_{met.compartment}\"\n", + " bigg_writer.writerow([row[0], new_rxn_id])\n", + " except KeyError:\n", + " pass\n", + "\n", + "# Rename file:\n", + "import os\n", + "os.remove(file_name)\n", + "os.rename(new_file_name, file_name)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## 6. Transport rxns\n", + "\n", + "For all transports of the type `met_a -> met_b` We will use as standard `METtab`:" + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "metadata": {}, + "outputs": [], + "source": [ + "# Tranlsator for compartments:\n", + "def translate_compartment(compartment):\n", + " if compartment == \"p\":\n", + " compartment = \"x\"\n", + " elif compartment == \"er\":\n", + " compartment = \"r\"\n", + " elif compartment == \"erm\":\n", + " compartment = \"rm\"\n", + " elif compartment in [\"c\",\"e\"]:\n", + " compartment = \"\" # cytosol/extracellular are typically not indicated in the BiGG id\n", + " return compartment\n", + "\n", + "# Create new BiGG ids for exchange rxns:\n", + "import cobra\n", + "model = cobra.io.read_sbml_model(\"../../ModelFiles/xml/yeastGEM.xml\")\n", + "file_name = '../../ComplementaryData/databases/BiGGrxnDictionary_newIDs.csv'\n", + "new_file_name = file_name.replace(\".csv\",\"_new.csv\")\n", + "with open(file_name) as old_file:\n", + " with open(new_file_name, 'w', newline='') as new_file:\n", + " bigg_reader = csv.reader(old_file, delimiter=',')\n", + " bigg_writer = csv.writer(new_file, delimiter=',')\n", + " for row in bigg_reader:\n", + " try:\n", + " rxn = model.reactions.get_by_id(row[0])\n", + " new_rxn_id = row[1]\n", + " if len(rxn.metabolites) == 2:\n", + " sub = list(rxn.reactants)[0]\n", + " pro = list(rxn.products)[0]\n", + " sub_id = met_bigg_dict[sub.id]\n", + " pro_id = met_bigg_dict[pro.id]\n", + " if sub_id == pro_id:\n", + " sub_c = translate_compartment(sub.compartment)\n", + " pro_c = translate_compartment(pro.compartment)\n", + " new_rxn_id = f\"{sub_id.upper()}t{sub_c}{pro_c}\"\n", + " bigg_writer.writerow([row[0], new_rxn_id])\n", + " except KeyError:\n", + " pass\n", + "\n", + "# Rename file:\n", + "import os\n", + "os.remove(file_name)\n", + "os.rename(new_file_name, file_name)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## 7. Lipid rxn ids\n", + "\n", + "The position of the chain is redundant information, e.g. `KIN11812181gm` can just be `KIN181181gm`" + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "metadata": {}, + "outputs": [], + "source": [ + "# Create new BiGG ids compliant with lipid standards:\n", + "import cobra\n", + "import csv\n", + "from copy import copy\n", + "from re import findall\n", + "model = cobra.io.read_sbml_model(\"../../ModelFiles/xml/yeastGEM.xml\")\n", + "file_name = '../../ComplementaryData/databases/BiGGrxnDictionary_newIDs.csv'\n", + "new_file_name = file_name.replace(\".csv\",\"_new.csv\")\n", + "with open(file_name) as old_file:\n", + " with open(new_file_name, 'w', newline='') as new_file:\n", + " bigg_reader = csv.reader(old_file, delimiter=',')\n", + " bigg_writer = csv.writer(new_file, delimiter=',')\n", + " for row in bigg_reader:\n", + " rxn = model.reactions.get_by_id(row[0])\n", + " new_rxn_id = row[1]\n", + " chains = findall('\\(.*?\\)',rxn.name)\n", + " if len(chains) > 0:\n", + " bad_number = \"\"\n", + " good_number = \"\"\n", + " for chain in chains:\n", + " good_chain = copy(chain)\n", + " for num in \"1234\":\n", + " good_chain = good_chain.replace(num + \"-\", \"\") # the order of chains is implied from the string\n", + " for bad_char in \" ():,-\":\n", + " chain = chain.replace(bad_char, \"\") # to stay BiGG compliant\n", + " good_chain = good_chain.replace(bad_char, \"\") # to stay BiGG compliant\n", + " bad_number = bad_number + chain\n", + " good_number = good_number + good_chain\n", + " new_rxn_id = new_rxn_id.replace(bad_number, good_number)\n", + " bigg_writer.writerow([row[0], new_rxn_id])\n", + "\n", + "# Rename file:\n", + "import os\n", + "os.remove(file_name)\n", + "os.rename(new_file_name, file_name)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "metadata": {}, + "outputs": [], + "source": [] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.7.7" + } + }, + "nbformat": 4, + "nbformat_minor": 4 +} diff --git a/ComplementaryScripts/missingFields/addBiGGidentifiers.m b/ComplementaryScripts/missingFields/addBiGGidentifiers.m new file mode 100644 index 00000000..c55f303a --- /dev/null +++ b/ComplementaryScripts/missingFields/addBiGGidentifiers.m @@ -0,0 +1,33 @@ +function addBiGGidentifiers +% addBiGGidentifiers +% Loads the model, adds all BiGG identifiers for both metabolites and +% reactions, and saves the model back. +% +% Sebastian N. Mendoza, 2019-03-15 +% Benjamin J. Sanchez, 2020-05-05 +% + +% Load model: +cd .. +initCobraToolbox +model = loadYeastModel; + +% Add metabolite ids: +[~,met_dic] = xlsread('../ComplementaryData/databases/BiGGmetDictionary.csv'); +model.metBiGGID = cell(size(model.mets)); +for i = 1:size(met_dic,1) + model.metBiGGID(strcmp(model.mets,met_dic{i,1})) = met_dic(i,2); +end + +% Add reaction ids: +[~,rxn_dic] = xlsread('../ComplementaryData/databases/BiGGrxnDictionary.csv'); +model.rxnBiGGID = cell(size(model.rxns)); +for i = 1:size(rxn_dic,1) + model.rxnBiGGID(strcmp(model.rxns,rxn_dic{i,1})) = rxn_dic(i,2); +end + +% Save model: +saveYeastModel(model); +cd missingFields + +end diff --git a/ComplementaryScripts/missingFields/mapIDsViaMNXref.m b/ComplementaryScripts/missingFields/mapIDsViaMNXref.m index fadafca7..819c5e8e 100644 --- a/ComplementaryScripts/missingFields/mapIDsViaMNXref.m +++ b/ComplementaryScripts/missingFields/mapIDsViaMNXref.m @@ -1,162 +1,162 @@ -function targetList=mapIDsViaMNXref(type,queryList,fromDB,toDB) -% mapIDsViaMNXref -% -% Associate reaction/metabolite identifiers between different databases -% -% type 'rxns' or 'mets' depending on which information is -% expected to associate -% queryList cell array of reaction/metabolite in the query database -% (e.g. model.rxnKEGGID, model.metChEBIID) -% fromDB the query database name -% toDB the subject database name -% -% targetList cell array of reaction/metabolite in the subjuct database -% -% Note: This function map metabolite identifiers across -% different databases using the MNXref naming convention -% reference MNX structure comes from RAVEN repository -% -% Usage: targetList=mapIDsViaMNXref(type,queryList,fromDB,toDB) -% -% Hao Wang, 2018-05-23 -% - -targetList={}; - -if nargin<4 - EM='Missing input arguments'; - disp(EM); -end - -if isequal(fromDB,toDB) - EM='Query and subject databases cannot be the same!'; - disp(EM); -end - -% Load MNXref data structure, this part of code is modified by Feiran, in -% order to load data structure from RAVEN repository since the data is -% stored in raven toolbox. -%since right now, MNX reference structure only exist in the RAVEN branch: -%origin/feat/add_MetaNetX, we need to switch devel branch to that branch, load -%the file and switch back. -%remember when this branch is merged to the master branch, change codes -%below. -IDfile = 'ravenCobraWrapper.m'; -currentPath = pwd; -%Try to find root of toolbox: -try - toolboxPath = which(IDfile); %full file path - slashPos = getSlashPos(toolboxPath); - toolboxPath = toolboxPath(1:slashPos(end)); %folder path - %Go up until the root is found: - D = dir(toolboxPath); - while ~ismember({'.git'},{D.name}) - slashPos = getSlashPos(toolboxPath); - toolboxPath = toolboxPath(1:slashPos(end-1)); - D = dir(toolboxPath); - end - cd(toolboxPath); - -catch - disp([toolbox ' toolbox cannot be found']) -end -%Check if this branch is feat/add_MetaNetX -currentBranch = git('rev-parse --abbrev-ref HEAD'); -if ~strcmp(currentBranch,'feat/add_MetaNetX') - git checkout feat/add_MetaNetX - currentBranch = git('rev-parse --abbrev-ref HEAD'); - if ~strcmp(currentBranch,'feat/add_MetaNetX') - error(['ERROR: branch:add_MetaNetX not exists. Check-out the RAVEN toolbox:https://github.com/SysBioChalmers/RAVEN']) - end -end -cd external/MetaNetX/ -load('MNXref.mat'); -% swich back to the master branch of RAVEN -git checkout master -cd(currentPath); - -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% - -% Associate reaction or metabolite -if strcmpi(type,'rxns') - MNXref=MNXrefRxns; -elseif strcmpi(type,'mets') - MNXref=MNXrefMets; -else - EM='Incorrect value of the "type" parameter. Allowed values are "rxns" or "mets"'; - dispEM(EM); -end - -% Supported database names -dbNames=regexp(fieldnames(MNXref),'(\w+)MNXid','tokens'); -dbNames=cellfun(@string,dbNames,'un',0); -dbNames=cellfun(@char,dbNames,'un',0); -dbNames=[dbNames;'MetaNetX']; -dbNames=setdiff(dbNames,{''}); - -if ~all(ismember({fromDB;toDB},dbNames)) - fprintf('Unknown database names! Please select from the following supported ones:\n'); - for i=1:numel(dbNames) - fprintf(' %s\n',dbNames{i}); - end - return; -end - -%Prepare field names -fromDBField=strcat(fromDB,'xref'); -fromMNXField=strcat(fromDB,'MNXid'); -toMNXField=strcat(toDB,'MNXid'); -toDBField=strcat(toDB,'xref'); - -% Initilize output cell array -targetList=cell(numel(queryList),1); -targetList(:)={''}; - -% In case of using MNX ids as query -if isequal('MetaNetX',fromDB) - [a, b]=ismember(queryList,MNXref.(toMNXField)); - targetList(find(a))=MNXref.(toDBField)(b(find(a))); - dispNum(targetList,MNXref.Version); - return; -end - -% Get the intermedia MNX identifiers -MNXids=cell(numel(queryList),1); -MNXids(:)={''}; -[a, b]=ismember(queryList,MNXref.(fromDBField)); -MNXids(find(a))=MNXref.(fromMNXField)(b(find(a))); - -% In case of targting for MNX ids -if isequal('MetaNetX',toDB) - targetList=MNXids; - dispNum(targetList,MNXref.Version); - return; -end - -% Map intermedia MNX identifiers one by one -for i=1:numel(MNXids) - if ~isempty(MNXids{i}) - index=strcmp(MNXids{i},MNXref.(toMNXField)); - if length(find(index))==1 - targetList{i}=MNXref.(toDBField){find(index)}; - elseif length(find(index))>1 - targetList{i}=strjoin(MNXref.(toDBField)(find(index)),';'); - end - end -end -dispNum(targetList,MNXref.Version); - -end - -% This subfunction counts and prints out the associated number -function dispNum(List,ver) -num=numel(find(~cellfun(@isempty,List))); -fprintf('%s ids were associated by MetaNetX version %s.\n',num2str(num),ver); -end - -function slashPos = getSlashPos(path) -slashPos = strfind(path,'\'); %Windows -if isempty(slashPos) - slashPos = strfind(path,'/'); %MAC/Linux -end -end +function targetList=mapIDsViaMNXref(type,queryList,fromDB,toDB) +% mapIDsViaMNXref +% +% Associate reaction/metabolite identifiers between different databases +% +% type 'rxns' or 'mets' depending on which information is +% expected to associate +% queryList cell array of reaction/metabolite in the query database +% (e.g. model.rxnKEGGID, model.metChEBIID) +% fromDB the query database name +% toDB the subject database name +% +% targetList cell array of reaction/metabolite in the subjuct database +% +% Note: This function map metabolite identifiers across +% different databases using the MNXref naming convention +% reference MNX structure comes from RAVEN repository +% +% Usage: targetList=mapIDsViaMNXref(type,queryList,fromDB,toDB) +% +% Hao Wang, 2018-05-23 +% + +targetList={}; + +if nargin<4 + EM='Missing input arguments'; + disp(EM); +end + +if isequal(fromDB,toDB) + EM='Query and subject databases cannot be the same!'; + disp(EM); +end + +% Load MNXref data structure, this part of code is modified by Feiran, in +% order to load data structure from RAVEN repository since the data is +% stored in raven toolbox. +%since right now, MNX reference structure only exist in the RAVEN branch: +%origin/feat/add_MetaNetX, we need to switch devel branch to that branch, load +%the file and switch back. +%remember when this branch is merged to the master branch, change codes +%below. +IDfile = 'ravenCobraWrapper.m'; +currentPath = pwd; +%Try to find root of toolbox: +try + toolboxPath = which(IDfile); %full file path + slashPos = getSlashPos(toolboxPath); + toolboxPath = toolboxPath(1:slashPos(end)); %folder path + %Go up until the root is found: + D = dir(toolboxPath); + while ~ismember({'.git'},{D.name}) + slashPos = getSlashPos(toolboxPath); + toolboxPath = toolboxPath(1:slashPos(end-1)); + D = dir(toolboxPath); + end + cd(toolboxPath); + +catch + disp([toolbox ' toolbox cannot be found']) +end +%Check if this branch is feat/add_MetaNetX +currentBranch = git('rev-parse --abbrev-ref HEAD'); +if ~strcmp(currentBranch,'feat/add_MetaNetX') + git checkout feat/add_MetaNetX + currentBranch = git('rev-parse --abbrev-ref HEAD'); + if ~strcmp(currentBranch,'feat/add_MetaNetX') + error(['ERROR: branch:add_MetaNetX not exists. Check-out the RAVEN toolbox:https://github.com/SysBioChalmers/RAVEN']) + end +end +cd external/MetaNetX/ +load('MNXref.mat'); +% swich back to the master branch of RAVEN +git checkout master +cd(currentPath); + +%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% + +% Associate reaction or metabolite +if strcmpi(type,'rxns') + MNXref=MNXrefRxns; +elseif strcmpi(type,'mets') + MNXref=MNXrefMets; +else + EM='Incorrect value of the "type" parameter. Allowed values are "rxns" or "mets"'; + dispEM(EM); +end + +% Supported database names +dbNames=regexp(fieldnames(MNXref),'(\w+)MNXid','tokens'); +dbNames=cellfun(@string,dbNames,'un',0); +dbNames=cellfun(@char,dbNames,'un',0); +dbNames=[dbNames;'MetaNetX']; +dbNames=setdiff(dbNames,{''}); + +if ~all(ismember({fromDB;toDB},dbNames)) + fprintf('Unknown database names! Please select from the following supported ones:\n'); + for i=1:numel(dbNames) + fprintf(' %s\n',dbNames{i}); + end + return; +end + +%Prepare field names +fromDBField=strcat(fromDB,'xref'); +fromMNXField=strcat(fromDB,'MNXid'); +toMNXField=strcat(toDB,'MNXid'); +toDBField=strcat(toDB,'xref'); + +% Initilize output cell array +targetList=cell(numel(queryList),1); +targetList(:)={''}; + +% In case of using MNX ids as query +if isequal('MetaNetX',fromDB) + [a, b]=ismember(queryList,MNXref.(toMNXField)); + targetList(find(a))=MNXref.(toDBField)(b(find(a))); + dispNum(targetList,MNXref.Version); + return; +end + +% Get the intermedia MNX identifiers +MNXids=cell(numel(queryList),1); +MNXids(:)={''}; +[a, b]=ismember(queryList,MNXref.(fromDBField)); +MNXids(find(a))=MNXref.(fromMNXField)(b(find(a))); + +% In case of targting for MNX ids +if isequal('MetaNetX',toDB) + targetList=MNXids; + dispNum(targetList,MNXref.Version); + return; +end + +% Map intermedia MNX identifiers one by one +for i=1:numel(MNXids) + if ~isempty(MNXids{i}) + index=strcmp(MNXids{i},MNXref.(toMNXField)); + if length(find(index))==1 + targetList{i}=MNXref.(toDBField){find(index)}; + elseif length(find(index))>1 + targetList{i}=strjoin(MNXref.(toDBField)(find(index)),';'); + end + end +end +dispNum(targetList,MNXref.Version); + +end + +% This subfunction counts and prints out the associated number +function dispNum(List,ver) +num=numel(find(~cellfun(@isempty,List))); +fprintf('%s ids were associated by MetaNetX version %s.\n',num2str(num),ver); +end + +function slashPos = getSlashPos(path) +slashPos = strfind(path,'\'); %Windows +if isempty(slashPos) + slashPos = strfind(path,'/'); %MAC/Linux +end +end diff --git a/ComplementaryScripts/modelCuration/changerxn.m b/ComplementaryScripts/modelCuration/changerxn.m new file mode 100644 index 00000000..fe9fc2b1 --- /dev/null +++ b/ComplementaryScripts/modelCuration/changerxn.m @@ -0,0 +1,68 @@ +function model = changerxn(model,rxnID,rxnformula,grRule) +% changerxn +% Change the metabolites in the reaction +% +% model COBRA model structure +% rxnID ID of the reaction i.e. identifier in model.rxns +% rxnFormula Reaction formula in string format +% (A [comp] + B [comp] -> C [comp]) +% For metabolites with space in model.metNames e.g. +% 1-pyrroline-3-hydroxy-5-carboxylic acid, use symbol '&' +% to substitute space ' ' i.e. 1-pyrroline-3-hydroxy-5-carboxylic&acid +% grRule Gene-reaction rule in boolean format (and/or allowed) +% (opt, default model.grRule from RAVEN model structure) +% +% Note: model.mets is generated for new metabolites with prefix 's_' +% +% Usage: model = changerxn(model,rxnID,rxnformula,grRule) +% +% Feiran Li, 2020-05-24 +% Cheng Wei Quan (Eiden), added documentation, 2020-05-24 + +[~,idx] = ismember(rxnID,model.rxns); +if nargin < 4 + if isfield(model,'grRules') + grRule = model.grRules{idx}; + else + model1 = ravenCobraWrapper(model); + grRule = model1.grRules{idx}; + end +end + +rxnformula = strrep(rxnformula,' [','['); +[metaboliteList, stoichCoeffList, revFlag] = parseRxnFormula(rxnformula); +metaboliteList = strrep(metaboliteList,'[',' ['); +metaboliteList = strrep(metaboliteList,'&',' '); +comps = split(metaboliteList', ' ['); +comps = comps(:,2); +comps = strrep(comps,']',''); +CONValldata = cat(2,model.compNames,model.comps); +[~,b] = ismember(comps,CONValldata(:,1)); +comps = CONValldata(b,2); + +%mapping mets to model.metnames, get s_ index for new mets +for j = 1:length(metaboliteList) + [~,metindex] = ismember(metaboliteList(j),model.metNames); + if metindex ~= 0 + mets(j) = model.mets(metindex); + elseif metindex == 0 + cd ../otherChanges/ + newID = getNewIndex(model.mets); + cd ../modelCuration/ + mets(j) = strcat('s_',newID,'[',comps(j),']'); + model = addMetabolite(model,char(mets(j)), ... + 'metName',metaboliteList{j}); + end +end + + +[model, rxnIDexists] = addReaction(model,... + rxnID,... + 'reactionName', model.rxnNames{idx},... + 'metaboliteList',mets,... + 'stoichCoeffList',stoichCoeffList,... + 'reversible',revFlag,... + 'geneRule',grRule,... + 'checkDuplicate',1); + +end diff --git a/ComplementaryScripts/modelCuration/checkRxnBalance.m b/ComplementaryScripts/modelCuration/checkRxnBalance.m new file mode 100644 index 00000000..6e191761 --- /dev/null +++ b/ComplementaryScripts/modelCuration/checkRxnBalance.m @@ -0,0 +1,104 @@ +% This function is to identify charge and mass balance for reactions +% +% Input: model and reaction identifier(s) in model.rxns (e.g. 'r_0001') +% Output: MassChargeresults +% For exchange reactions: +% reaction identifier(s) and 'exchange' will be displayed in +% MassChargeresults +% +% For balanced reactions: +% reaction identifier(s) and 'pass' will be displayed in +% MassChargeresults +% +% For reaction identifier(s) which does not match model.rxns: +% 'rxnID not found' and 'manual check required' will be displayed +% in MassChargeresults +% +% For reactions with elemental and/or charge imbalance(s): +% reaction identifier(s), specific imbalance issue(s) to check, +% individual charges of each metabolite in the reaction (if there +% is charge difference), charge difference and elemental difference +% will be displayed in MassChargeresults +% +% NOTE: getElementalBalance.m is a function from RAVEN +% +% Usage: MassChargeresults = checkRxnBalance(model,rxn) +% +% modified from Feiran Li's script 'checkBalanceforSce.m' +% +% Cheng Wei Quan (Eiden), 2020-05-06 + +function MassChargeresults = checkRxnBalance(model,rxn) +exchangeRxns = findExcRxns(model); +MassChargeresults{length(rxn),5} = []; +for i = 1:length(rxn) + [~,rxnID] = ismember(rxn(i),model.rxns); + if rxnID ~= 0 + if exchangeRxns(rxnID) == 1 + arrayidx = find(cellfun('isempty', MassChargeresults),1); + MassChargeresults(arrayidx,1) = model.rxns(rxnID); + MassChargeresults(arrayidx,2) = {'exchange'}; + else + %check mass balance + balanceStructure=getElementalBalance(model,rxn(i)); + unbalancedidx = find(balanceStructure.balanceStatus==0); + missingidx = find(balanceStructure.balanceStatus==-1); + idx = union(unbalancedidx,missingidx); + for j=1:length(idx) + dif = balanceStructure.leftComp(idx(j),:) - balanceStructure.rightComp(idx(j),:); + mets = find(~dif==0); + difference = ''; + for k=1:length(mets) + difference = strcat(difference,balanceStructure.elements.abbrevs(mets(k))); + difference = strcat(difference,num2str(dif(mets(k)))); + end + out = difference; + end + %check charge balance + mets=find(model.S(:,rxnID)); + coef = model.metCharges(mets); + if length(mets) == length(coef) + indvCharge = model.S(mets,rxnID).*coef; + balanceCharge = sum(model.S(mets,rxnID).*coef); + else + balanceCharge = -1; + end + if balanceStructure.balanceStatus == 1 && balanceCharge == 0 + arrayidx = find(cellfun('isempty', MassChargeresults),1); + MassChargeresults(arrayidx,1) = model.rxns(rxnID); + MassChargeresults(arrayidx,2) = {'pass'}; + elseif balanceStructure.balanceStatus == 1 && balanceCharge ~= 0 + arrayidx = find(cellfun('isempty', MassChargeresults),1); + MassChargeresults(arrayidx,1) = model.rxns(rxnID); + MassChargeresults(arrayidx,2) = {'checkMetCharge'}; + MassChargeresults(arrayidx,3) = {indvCharge}; + MassChargeresults(arrayidx,4) = {balanceCharge}; + elseif balanceStructure.balanceStatus == 0 && balanceCharge == 0 + arrayidx = find(cellfun('isempty', MassChargeresults),1); + MassChargeresults(arrayidx,1) = model.rxns(rxnID); + MassChargeresults(arrayidx,2) = {'checkMetFormula'}; + MassChargeresults(arrayidx,5) = out; + elseif balanceStructure.balanceStatus == 0 && balanceCharge ~= 0 + arrayidx = find(cellfun('isempty', MassChargeresults),1); + MassChargeresults(arrayidx,1) = model.rxns(rxnID); + MassChargeresults(arrayidx,2) = {'checkMetChargeAndFormula'}; + MassChargeresults(arrayidx,3) = {indvCharge}; + MassChargeresults(arrayidx,4) = {balanceCharge}; + MassChargeresults(arrayidx,5) = out; + elseif balanceStructure.balanceStatus == -1 + arrayidx = find(cellfun('isempty', MassChargeresults),1); + MassChargeresults(arrayidx,1) = model.rxns(rxnID); + MassChargeresults(arrayidx,2) = {'unbalanced due to missing information'}; + MassChargeresults(arrayidx,3) = {indvCharge}; + MassChargeresults(arrayidx,4) = {balanceCharge}; + MassChargeresults(arrayidx,5) = {'-'}; + end + end + else + arrayidx = find(cellfun('isempty', MassChargeresults),1); + MassChargeresults(arrayidx,1) = {'rxnID not found'}; + MassChargeresults(arrayidx,2) = {'manual check required'}; + end +end + +end diff --git a/ComplementaryScripts/modelCuration/checkSmatrixMNX.m b/ComplementaryScripts/modelCuration/checkSmatrixMNX.m new file mode 100644 index 00000000..5f681bc8 --- /dev/null +++ b/ComplementaryScripts/modelCuration/checkSmatrixMNX.m @@ -0,0 +1,370 @@ +% This script does an automated check of reaction balance in the model by +% comparing the S matrix of the model reactions +% to the S matrix of the MNX reactions via the MNXRID and MNXMID +% +% If a reaction is only missing either H+ or H2O (i.e. MNXM1 or MNXM2), and +% if the reaction in MNX database is balanced, then model.S will be +% modified accordingly to balance the equation +% +% Inputs: model, reac_prop.tsv +% Outputs: noMNXRID, noCoef, coefNoMatch, missingrxnmets, balanced and +% changeMNXM +% +% The outputs of this script can be used to facilitate manual curation of +% reaction balance in the model +% +% Note: This automatic curation had little impact in reactifying +% reaction balance in the model, but the outputs were helpful +% in the manual curation process of reaction balance +% The script was thus added into repository for documentation purposes +% +% Cheng Wei Quan (Eiden), 2020-05-20 + +%Load model +cd .. +model = loadYeastModel; + +%Check for reac_prop.tsv in current directory +%If not available, file will be downloaded +downloadMNXdb('reac_prop',pwd) + +%Load reac_prop.tsv file +fileDir = dir('reac_prop.tsv'); +if ~isempty(fileDir) %check if reactions.tsv is present in current directory + fid = fopen('reac_prop.tsv'); + format = repmat('%s ',1,6); + format = strtrim(format); + rxn_temp = textscan(fid,format,'Delimiter','\t','HeaderLines',0); + for i = 1:length(rxn_temp) + MNXreac_prop(:,i) = rxn_temp{i}; + end + commentLines = startsWith(MNXreac_prop(:,1),'#'); + MNXreac_prop(commentLines,:) = []; %MNXRID Equation Description Balance EC Source + fclose(fid); + + %% Generate S matrix for MNX and model for comparison + + %Preallocate cell arrays + noMNXRID{3991,2} = []; + noCoef{3991,2} = []; + coefNoMatch{3991,2} = []; + allmetsDiff{3991,2} = []; + balanced{3991,2} = []; + changeMNXM{3991,2} = []; + missingrxnmets{3991,2} = []; + extrarxnmets{3991,2} = []; + uncertainComp{3991,2} = []; + modelR = ravenCobraWrapper(model); + + for i = 1:length(model.rxns) + [~,rxnIdx] = ismember(model.rxnMetaNetXID(i),MNXreac_prop(:,1)); + if isequal(rxnIdx,0) + arrayidx = find(cellfun('isempty', noMNXRID),1); + noMNXRID(arrayidx,:) = [model.rxns(i), 'MNXRID not found, please check and modify to a new ID']; + else + rxn = strrep(MNXreac_prop(rxnIdx,2),'=','<=>'); + [S, mets]=constructS(rxn); + matrix.metcoef = S; + if isequal(matrix.metcoef,0) + arrayidx = find(cellfun('isempty', noCoef),1); + noCoef(arrayidx,:) = [model.rxns(i), 'Coefficient of mets are not found, please check and modify accordingly']; + else + temp = split(mets,'@',2); + matrix.metMetaNetXID = cellstr(temp(:,1)); + + %Fix the issue for H+: two IDs to represent H+ in MNX database + matrix.metMetaNetXID(ismember(matrix.metMetaNetXID,'MNXM01')) = {'MNXM1'}; % + MNXrefrxn = [matrix.metMetaNetXID,num2cell(matrix.metcoef)]; + coef = model.S(:,i); + mets_temp = (find(model.S(:,i))); + mets_MNX = model.metMetaNetXID(mets_temp); + mets_coef = coef(mets_temp); + metComps = modelR.metComps; + metComps = modelR.comps(metComps); + mets_comp = metComps(mets_temp); + modelrefrxn = [mets_MNX,num2cell(mets_coef),mets_comp]; + + if any(ismember(mets_MNX,'')) + arrayidx = find(cellfun('isempty', missingrxnmets),1); + missingrxnmets(arrayidx,:) = [model.rxns(i), 'mets_MNX contains empty cell array']; + + elseif~all(ismember(mets_MNX,matrix.metMetaNetXID)) || ~all(ismember(matrix.metMetaNetXID,mets_MNX)) + diffmets = setdiff(matrix.metMetaNetXID,mets_MNX); + diffmets2 = setdiff(mets_MNX, matrix.metMetaNetXID); + excl_mets = {'MNXM1';'MNXM2'}; + missingidx = ismember(excl_mets,diffmets); + missingmets = excl_mets(missingidx); + missingidx2 = ~ismember(diffmets,excl_mets); + extraidx = ismember(excl_mets,diffmets2); + extramets = excl_mets(extraidx); + extraidx2 = ~ismember(diffmets2,excl_mets); + + %Find any missing/extra mets (other than H+/H2O) + if any(missingidx2) && ~isempty(diffmets) + for l = 1:length(missingidx2) + if missingidx2(l) && length(diffmets) > 1 + arrayidx = find(cellfun('isempty', missingrxnmets),1); + missingrxnmets(arrayidx,:) = [model.rxns(i), join([diffmets(l),'is missing from rxn in the model'])]; + elseif missingidx2(l) && length(diffmets) == 1 + arrayidx = find(cellfun('isempty', missingrxnmets),1); + missingrxnmets(arrayidx,:) = [model.rxns(i), join([diffmets,'is missing from rxn in the model'])]; + end + end + elseif any(extraidx2) && ~isempty(diffmets2) + for l = 1:length(extraidx2) + if extraidx2(l) && length(diffmets2) > 1 + arrayidx = find(cellfun('isempty', extrarxnmets),1); + extrarxnmets(arrayidx,:) = [model.rxns(i), join([diffmets2(l),'is extra in the model rxn'])]; + elseif extraidx2(l) && length(diffmets2) == 1 + arrayidx = find(cellfun('isempty', extrarxnmets),1); + extrarxnmets(arrayidx,:) = [model.rxns(i), join([diffmets2,'is extra in the model rxn'])]; + end + end + + else + %add/remove H+/H2O into reaction if equation is balanced in MNX database + for j = 1:length(excl_mets) + if missingidx(j) && isequal(MNXreac_prop(rxnIdx,4),{'TRUE'}) + mets_MNX(length(mets_MNX) + 1,1) = excl_mets(j); + + [~,idx] = ismember(mets_MNX,matrix.metMetaNetXID); + matrix.metMetaNetXID = matrix.metMetaNetXID(idx); + matrix.metcoef = matrix.metcoef(idx); + coef_idx = ismember(excl_mets(j),matrix.metMetaNetXID); + coef_idx2 = find(ismember(matrix.metMetaNetXID, excl_mets(j))); + + %Check whether model and MNX database rxn is in the same direction + for o = 1:length(mets_coef) + if ~ismember(mets_MNX(o),excl_mets) + if abs(mets_coef(o)) == abs(matrix.metcoef(o)) && mets_coef(o) ~= matrix.metcoef(o) + matrix.metcoef = matrix.metcoef.*(-1); + break + end + end + end + + %check and add coef for H+/H2O + if coef_idx && isequal(MNXreac_prop(rxnIdx,4),{'TRUE'}) + rxn_comp = unique(mets_comp); + %only change coefficient if there is only 1 compartment + if length(rxn_comp) == 1 + mets_locate = find(ismember(model.metMetaNetXID,excl_mets(j))); + metComps2 = modelR.metComps; + mets_comp2 = metComps2(mets_temp); + samemets_comp = find(ismember(modelR.metComps,mets_comp2(1))); + model.S(intersect(mets_locate,samemets_comp),i) = matrix.metcoef(coef_idx2); + coef = model.S(:,i); + mets_temp = (find(model.S(:,i))); + mets_MNX = model.metMetaNetXID(mets_temp); + mets_coef = coef(mets_temp); + + [~,idx] = ismember(mets_MNX,matrix.metMetaNetXID); + matrix.metMetaNetXID = matrix.metMetaNetXID(idx); + matrix.metcoef = matrix.metcoef(idx); + + %check coef + if isequal(mets_coef,matrix.metcoef) || isequal(mets_coef,matrix.metcoef.*(-1)) + arrayidx = find(cellfun('isempty', changeMNXM),1); + changeMNXM(arrayidx,:) = [model.rxns(i),join([excl_mets(j), 'is added with coefficient of',num2str(matrix.metcoef(coef_idx2)),'to balance eqn'])]; + model.rxnNotes(i) = join([model.rxnNotes(i),'|',excl_mets(j),'added (PR #222)']); + else + arrayidx = find(cellfun('isempty', coefNoMatch),1); + coefNoMatch(arrayidx,:) = [model.rxns(i),join([excl_mets(j), 'is added with coefficient of',num2str(matrix.metcoef(coef_idx2)),'to balance eqn but coef still does not match'])]; + end + else + arrayidx = find(cellfun('isempty', uncertainComp),1); + uncertainComp(arrayidx,:) = [model.rxns(i), join([excl_mets(j),'needs to be added, check which compartment',excl_mets(j),'belongs to in the reaction'])]; + end + else + end + + elseif extraidx(j) && isequal(MNXreac_prop(rxnIdx,4),{'TRUE'}) + extramets_comp = mets_comp(find(ismember(mets_MNX,extramets))); + extramets_locate = find(ismember(model.metMetaNetXID,extramets)); + samemets_comp = find(ismember(modelR.metComps,find(ismember(modelR.comps,extramets_comp)))); + model.S(intersect(extramets_locate,samemets_comp),i) = 0; + coef = model.S(:,i); + mets_temp = (find(model.S(:,i))); + mets_MNX = model.metMetaNetXID(mets_temp); + mets_coef = coef(mets_temp); + [~,idx] = ismember(mets_MNX,matrix.metMetaNetXID); + matrix.metMetaNetXID = matrix.metMetaNetXID(idx); + matrix.metcoef = matrix.metcoef(idx); + + %check coef + if isequal(mets_coef,matrix.metcoef) || isequal(mets_coef,matrix.metcoef.*(-1)) + arrayidx = find(cellfun('isempty', changeMNXM),1); + changeMNXM(arrayidx,:) = [model.rxns(i),join([excl_mets(j),'is removed to balance eqn'])]; + model.rxnNotes(i) = join([model.rxnNotes(i),'|',excl_mets(j),'is removed to match the balanced equation in MetaNetX database (PR #222)']); + else + arrayidx = find(cellfun('isempty', coefNoMatch),1); + coefNoMatch(arrayidx,:) = [model.rxns(i),join([excl_mets(j),'is removed to balance eqn, but model and MNX mets coef still do not match'])]; + end + end + end + end + + elseif ~any(ismember(mets_MNX,matrix.metMetaNetXID)) + arrayidx = find(cellfun('isempty', allmetsDiff),1); + allmetsDiff(arrayidx,:) = [model.rxns(i), join(['All mets in', model.rxns(i), 'of the model are different from database'])]; + + elseif all(ismember(mets_MNX,matrix.metMetaNetXID)) && all(ismember(matrix.metMetaNetXID, mets_MNX)) + %filter transport rxns in the model/rxns with repeated mets + if length(mets_MNX) == 2 && ismember(mets_MNX(1),mets_MNX(2)) + elseif length(unique(mets_MNX)) == 2 && ismember('MNXM1',mets_MNX) %for specific H+ transport reaction + %rearrange matrix.metMetaNetXID to match order of mets_MNX + %note that there are repeated data in the array + [~,idxA] = ismember(mets_MNX,matrix.metMetaNetXID); + [~,idxB] = ismember(cellstr(num2str(mets_coef)), cellstr(num2str(matrix.metcoef))); + matrix.metMetaNetXID = matrix.metMetaNetXID(idxA); + matrix.metcoef = matrix.metcoef(idxB); + elseif length(unique(mets_MNX)) < length(mets_MNX) && (~ismember('MNXM1',mets_MNX) || ~ismember('MNXM2',mets_MNX)) + [~,idxA] = ismember(mets_MNX,matrix.metMetaNetXID); + [~,idxB] = ismember(cellstr(num2str(mets_coef)), cellstr(num2str(matrix.metcoef))); + matrix.metMetaNetXID = matrix.metMetaNetXID(idxA); + matrix.metcoef = matrix.metcoef(idxB); + else + [~,idx] = ismember(mets_MNX,matrix.metMetaNetXID); + matrix.metMetaNetXID = matrix.metMetaNetXID(idx); + matrix.metcoef = matrix.metcoef(idx); + end + + if isequal(mets_coef,matrix.metcoef) || isequal(mets_coef,matrix.metcoef.*(-1)) + arrayidx = find(cellfun('isempty', balanced),1); + balanced(arrayidx,:) = [model.rxns(i),'Both mets and coef in model and MNX database matches']; + else + excl_mets = {'MNXM1';'MNXM2'}; + %check whether model and MNX database rxn is in the same direction + for o = 1:length(mets_coef) + if ~ismember(mets_MNX(o),excl_mets) + if abs(mets_coef(o)) == abs(matrix.metcoef(o)) && mets_coef(o) ~= matrix.metcoef(o) + matrix.metcoef = matrix.metcoef.*(-1); + break + end + end + end + for k = 1:length(excl_mets) + coef_idx = ismember(excl_mets(k),matrix.metMetaNetXID); + coef_idx2 = find(ismember(matrix.metMetaNetXID, excl_mets(k))); + %check and correct unbalanced H+/H2O + if coef_idx && isequal(MNXreac_prop(rxnIdx,4),{'TRUE'}) + for m = 1:length(coef_idx2) + if abs(matrix.metcoef(coef_idx2(m))) > abs(mets_coef(coef_idx2(m))) && mets_coef(coef_idx2(m)) < 0 + model.rxnNotes(i) = join([model.rxnNotes(i),'| Coefficient of',excl_mets(k),'modified from',num2str(mets_coef(coef_idx2(m))),'to',num2str(matrix.metcoef(coef_idx2(m))),'(PR #222)']); + mets_coef(coef_idx2(m)) = matrix.metcoef(coef_idx2(m)); + mets_locate = find(ismember(model.metMetaNetXID,excl_mets(k))); + metComps2 = modelR.metComps; + mets_comp2 = metComps2(mets_temp); + samemets_comp = find(ismember(modelR.metComps,mets_comp2(coef_idx2(m)))); + model.S(intersect(mets_locate,samemets_comp),i) = mets_coef(coef_idx2(m)); + + elseif abs(matrix.metcoef(coef_idx2(m))) > abs(mets_coef(coef_idx2(m))) && mets_coef(coef_idx2(m)) > 0 + model.rxnNotes(i) = join([model.rxnNotes(i),'| Coefficient of',excl_mets(k),'modified from',num2str(mets_coef(coef_idx2(m))),'to',num2str(matrix.metcoef(coef_idx2(m))),'(PR #222)']); + mets_coef(coef_idx2(m)) = matrix.metcoef(coef_idx2(m)); + mets_locate = find(ismember(model.metMetaNetXID,excl_mets(k))); + metComps2 = modelR.metComps; + mets_comp2 = metComps2(mets_temp); + samemets_comp = find(ismember(modelR.metComps,mets_comp2(coef_idx2(m)))); + model.S(intersect(mets_locate,samemets_comp),i) = mets_coef(coef_idx2(m)); + + elseif abs(matrix.metcoef(coef_idx2(m))) < abs(mets_coef(coef_idx2(m))) && mets_coef(coef_idx2(m)) < 0 + model.rxnNotes(i) = join([model.rxnNotes(i),'| Coefficient of',excl_mets(k),'modified from',num2str(mets_coef(coef_idx2(m))),'to',num2str(matrix.metcoef(coef_idx2(m))),'(PR #222)']); + mets_coef(coef_idx2(m)) = matrix.metcoef(coef_idx2(m)); + mets_locate = find(ismember(model.metMetaNetXID,excl_mets(k))); + metComps2 = modelR.metComps; + mets_comp2 = metComps2(mets_temp); + samemets_comp = find(ismember(modelR.metComps,mets_comp2(coef_idx2(m)))); + model.S(intersect(mets_locate,samemets_comp),i) = mets_coef(coef_idx2(m)); + + elseif abs(matrix.metcoef(coef_idx2(m))) < abs(mets_coef(coef_idx2(m))) && mets_coef(coef_idx2(m)) > 0 + model.rxnNotes(i) = join([model.rxnNotes(i),'| Coefficient of',excl_mets(k),'modified from',num2str(mets_coef(coef_idx2(m))),'to',num2str(matrix.metcoef(coef_idx2(m))),'(PR #222)']); + mets_coef(coef_idx2(m)) = matrix.metcoef(coef_idx2(m)); + mets_locate = find(ismember(model.metMetaNetXID,excl_mets(k))); + metComps2 = modelR.metComps; + mets_comp2 = metComps2(mets_temp); + samemets_comp = find(ismember(modelR.metComps,mets_comp2(coef_idx2(m)))); + model.S(intersect(mets_locate,samemets_comp),i) = mets_coef(coef_idx2(m)); + + elseif abs(matrix.metcoef(coef_idx2(m))) == abs(mets_coef(coef_idx2(m))) && matrix.metcoef(coef_idx2(m)) ~= mets_coef(coef_idx2(m)) + model.rxnNotes(i) = join([model.rxnNotes(i),'| Coefficient of',excl_mets(k),'modified from',num2str(mets_coef(coef_idx2(m))),'to',num2str(matrix.metcoef(coef_idx2(m))),'(PR #222)']); + mets_coef(coef_idx2(m)) = matrix.metcoef(coef_idx2(m)); + mets_locate = find(ismember(model.metMetaNetXID,excl_mets(k))); + metComps2 = modelR.metComps; + mets_comp2 = metComps2(mets_temp); + samemets_comp = find(ismember(modelR.metComps,mets_comp2(coef_idx2(m)))); + model.S(intersect(mets_locate,samemets_comp),i) = mets_coef(coef_idx2(m)); + else + end + end + end + end + if isequal(mets_coef,matrix.metcoef) || isequal(mets_coef,matrix.metcoef.*(-1)) + arrayidx = find(cellfun('isempty', changeMNXM),1); + changeMNXM(arrayidx,:) = [model.rxns(i),'Coef for H+/H2O has been modified (as indicated in model.rxnNotes) to balance rxn in model']; + else + arrayidx = find(cellfun('isempty', coefNoMatch),1); + coefNoMatch(arrayidx,:) = [model.rxns(i),'Mets in model and MNX database matches, but coef does not match']; + end + end + end + end + end + end + + %remove empty cells from cell arrays + arrayidx = ~cellfun('isempty',balanced(:,1)); + strtemp = balanced(:,1); + strtemp2 = balanced(:,2); + balanced = [strtemp(arrayidx),strtemp2(arrayidx)]; + + arrayidx = ~cellfun('isempty',changeMNXM(:,1)); + strtemp = changeMNXM(:,1); + strtemp2 = changeMNXM(:,2); + changeMNXM = [strtemp(arrayidx),strtemp2(arrayidx)]; + + arrayidx = ~cellfun('isempty',noMNXRID(:,1)); + strtemp = noMNXRID(:,1); + strtemp2 = noMNXRID(:,2); + noMNXRID = [strtemp(arrayidx),strtemp2(arrayidx)]; + + arrayidx = ~cellfun('isempty',noCoef(:,1)); + strtemp = noCoef(:,1); + strtemp2 = noCoef(:,2); + noCoef = [strtemp(arrayidx),strtemp2(arrayidx)]; + + arrayidx = ~cellfun('isempty',allmetsDiff(:,1)); + strtemp = allmetsDiff(:,1); + strtemp2 = allmetsDiff(:,2); + allmetsDiff = [strtemp(arrayidx),strtemp2(arrayidx)]; + + arrayidx = ~cellfun('isempty',coefNoMatch(:,1)); + strtemp = coefNoMatch(:,1); + strtemp2 = coefNoMatch(:,2); + coefNoMatch = [strtemp(arrayidx),strtemp2(arrayidx)]; + + arrayidx = ~cellfun('isempty',missingrxnmets(:,1)); + strtemp = missingrxnmets(:,1); + strtemp2 = missingrxnmets(:,2); + missingrxnmets = [strtemp(arrayidx),strtemp2(arrayidx)]; + + arrayidx = ~cellfun('isempty',extrarxnmets(:,1)); + strtemp = extrarxnmets(:,1); + strtemp2 = extrarxnmets(:,2); + extrarxnmets = [strtemp(arrayidx),strtemp2(arrayidx)]; + + %clear all variables except outputs of script + clearvars -except model noMNXRID noCoef coefNoMatch... + missingrxnmets balanced changeMNXM + + %remove reac_prop.tsv from current directory + delete('reac_prop.tsv'); + + % Remove leading '| ' in notes that were previously empty + model.rxnNotes = regexprep(model.rxnNotes,'^\| ',''); + model.metNotes = regexprep(model.metNotes,'^\| ',''); +else + warning('reac_prop.tsv is not downloaded into current directory, S matrix is not checked'); +end + +%save model +saveYeastModel(model); diff --git a/ComplementaryScripts/modelCuration/display_rxnMetInfo.m b/ComplementaryScripts/modelCuration/display_rxnMetInfo.m new file mode 100644 index 00000000..30174e9e --- /dev/null +++ b/ComplementaryScripts/modelCuration/display_rxnMetInfo.m @@ -0,0 +1,99 @@ +% This function is to output relevant metabolite data of a single reaction +% to facilitate manual curation +% +% Input: model and reaction identifier in model.rxns (e.g. 'r_0001') +% Output: editFormula (n x 9 cell array, n = number of mets in rxn) +% +% All mets info are displayed in the following order: +% model.mets, (met_idx, rxn_idx), model.metNames, +% model.metMetaNetXID,model.metKEGGID, model.metChEBIID, +% model.S, model.metCharges +% +% NOTE: reac_prop.tsv and chem_prop.tsv will be downloaded in current +% directory when using this function for the first time, if they +% cannot be not found - will increase the run time +% +% Usage: editFormula = display_rxnMetInfo(model,rxn_num) +% +% Cheng Wei Quan (Eiden), 2020-05-06 + +function editFormula = display_rxnMetInfo(model,rxn_num) +%Check for reac_prop.tsv in current directory +%If not available, file will be downloaded +downloadMNXdb('reac_prop',pwd) + +%Load reac_prop.tsv files from MNX database +fid2 = fopen('reac_prop.tsv'); +format = repmat('%s ',1,6); +format = strtrim(format); +rxn_temp = textscan(fid2,format,'Delimiter','\t','HeaderLines',0); +for i = 1:length(rxn_temp) + MNXreacprop(:,i) = rxn_temp{i}; +end +commentLines = startsWith(MNXreacprop(:,1),'#'); +MNXreacprop(commentLines,:) = []; % MNX_ID Equation Description Balance EC Source +fclose(fid2); + +%Check for chem_prop.tsv in current directory +%If not available, file will be downloaded +downloadMNXdb('chem_prop',pwd) + +%Load chem_prop.tsv files from MNX database +fid2 = fopen('chem_prop.tsv'); +format = repmat('%s ',1,9); +format = strtrim(format); +met_temp = textscan(fid2,format,'Delimiter','\t','HeaderLines',0); +for i = 1:length(met_temp) + MNXchemprop(:,i) = met_temp{i}; +end +commentLines = startsWith(MNXchemprop(:,1),'#'); +MNXchemprop(commentLines,:) = []; % MNX_ID Description Formula Charge Mass InChI SMILES Source InChIKey +fclose(fid2); + +%find the formula which causes equation to be unbalanced +bs = getElementalBalance(model); +idx = find(bs.balanceStatus==0); +out = model.rxns(idx); +rxn_idx = find(ismember(model.rxns,rxn_num)); + +%find element difference +dif = bs.leftComp(rxn_idx,:) - bs.rightComp(rxn_idx,:); +mets = find(~dif==0); +difference = ''; +for j=1:length(mets) + difference = strcat(difference,bs.elements.abbrevs(mets(j))); + difference = strcat(difference,num2str(dif(mets(j)))); +end + +%Find metFormulas in model +met_idx = find(model.S(:,rxn_idx)); +metNames = model.metNames(met_idx); +mets = model.mets(met_idx); +metFormulas = model.metFormulas(met_idx); +MNXmetID = model.metMetaNetXID(met_idx); +KEGGmetID = model.metKEGGID(met_idx); +ChEBImetID = model.metChEBIID(met_idx); +SmatrixCoef{length(met_idx),1} = []; +for i = 1:length(met_idx) + SmatrixCoef(i) = num2cell(model.S(met_idx(i),rxn_idx)); +end +metCharges = model.metCharges(met_idx); +arrayrows = max([length(MNXmetID),length(metFormulas),length(metCharges)]); + +editFormula{arrayrows,7} = []; +editFormula(1:length(mets),1) = mets; +for i = 1:length(met_idx) + editFormula(i,2) = {sprintf('%s, %s',string(met_idx(i)),string(rxn_idx))}; +end +editFormula(1:length(MNXmetID),3) = metNames; +editFormula(1:length(MNXmetID),4) = MNXmetID; +editFormula(1:length(KEGGmetID),5) = KEGGmetID; +editFormula(1:length(ChEBImetID),6) = ChEBImetID; +editFormula(1:length(metFormulas),7) = metFormulas; +editFormula(1:length(SmatrixCoef),8) = SmatrixCoef; +editFormula(1:length(metCharges),9) = num2cell(metCharges); + +editFormula(cellfun('isempty',editFormula)) = {0}; +editFormula = string(editFormula); + +end diff --git a/ComplementaryScripts/modelCuration/downloadMNXdb.m b/ComplementaryScripts/modelCuration/downloadMNXdb.m new file mode 100644 index 00000000..77d76a0d --- /dev/null +++ b/ComplementaryScripts/modelCuration/downloadMNXdb.m @@ -0,0 +1,37 @@ +function downloadMNXdb(files,mnxPath) +%downloadMNXdb Download MetaNetX database files if they cannot be found. +% +% files string or cell array of strings, with the MetaNetX files to +% be downloaded. Options: 'chem_xref', 'chem_prop', +% 'reac_xref', 'reac_prop' or 'all'. +% mnxPath string of path where MetaNetX reference files are +% stored. (opt, default to RAVENdir/external/metanetx) To +% download to current folder, specify pwd(). +% +% Usage: downloadMNXdb(files,mnxPath) +% +% Eduard Kerkhoven, 2020-05-04 + +if nargin<2 + [ST, I]=dbstack('-completenames'); + mnxPath=fileparts(fileparts(fileparts(ST(I).file))); + mnxPath=fullfile(mnxPath,'external','metanetx'); +end + +if ischar(files) + if strcmp(files,'all') + files={'chem_xref','chem_prop','reac_prop','reac_xref'}; + else + files={files}; + end +end + +for i=1:length(files) + if ~exist(fullfile(mnxPath,[files{i},'.tsv']), 'file') + fprintf('File %s.tsv cannot be found and will be downloaded from MetaNetX.org.\n',files{i}); + websave(fullfile(mnxPath,[files{i},'.tsv']),... + ['https://www.metanetx.org/cgi-bin/mnxget/mnxref/',files{i},'.tsv']); + end +end +end + diff --git a/ComplementaryScripts/modelCuration/mapKEGGID.m b/ComplementaryScripts/modelCuration/mapKEGGID.m new file mode 100644 index 00000000..13c4fb1a --- /dev/null +++ b/ComplementaryScripts/modelCuration/mapKEGGID.m @@ -0,0 +1,314 @@ +% This script maps reaction IDs and metabolite IDs of different databases +% to find new rxnKEGGID(s) and metKEGGID(s) +% +% Inputs: model +% +% getRxnsFromMetaCyc and getMetsFromMetaCyc are functions from RAVEN +% +% reactions.tsv and compounds.tsv from modelSEED database is downloaded directly from GitHub repository ModelSEEDDatabase +% link: github.com/ModelSEED/ModelSEEDDatabase +% +% Cheng Wei Quan (Eiden), 2020-05-07 + +%load model +cd .. +model = loadYeastModel; + +%% rxnKEGGID +%map rxnMetaNetXID to rxnKEGGID via function mapIDsViaMNXref +cd missingFields +xref_rxnKEGG = mapIDsViaMNXref('rxns',model.rxnMetaNetXID,'MetaNetX','KEGG'); +xref_rxnKEGG(:,2) = model.rxns; %match rxnKEGGID with model.rxns +xref_rxnKEGG(:,3) = model.rxnMetaNetXID; %match rxnKEGGID with model.rxnMetaNetXID +xref_rxnKEGG(:,4) = model.rxnKEGGID; %match rxnKEGGID with model.rxnKEGGID + +%only retain mapped rxnKEGGID if model.rxnKEGGID is empty +empties = find(cellfun('isempty',xref_rxnKEGG(:,1))); +xref_rxnKEGG(empties,:) = []; +empties = find(~cellfun('isempty',xref_rxnKEGG(:,4))); +xref_rxnKEGG(empties,:) = []; + +%add rxnKEGGID into model +[~,idx] = ismember(xref_rxnKEGG(:,2),model.rxns); +idx = idx(idx~=0); + +for i = 1:length(idx) + model.rxnKEGGID(idx(i)) = xref_rxnKEGG(i,1); +end + +%correction for MNXref error in MNXR96123/R00124#2 +idx = find(ismember(model.rxnMetaNetXID,'MNXR96123')); +model.rxnKEGGID(idx) = {'R00124'}; + +%map rxnMetaNetXID to rxnMetaCycID via function mapIDsViaMNXref, then map rxnMetaCycID to rxnKEGGID +xref_rxnMetaCyc = mapIDsViaMNXref('rxns',model.rxnMetaNetXID,'MetaNetX','MetaCyc'); +xref_rxnMetaCyc(:,2) = model.rxns; %match rxnMetaCycID with model.rxns +xref_rxnMetaCyc(:,3) = model.rxnMetaNetXID; %match rxnMetaCycID with model.rxnMetaNetXID +xref_rxnMetaCyc(:,4) = model.rxnKEGGID; %match rxnMetaCycID with model.rxnKEGGID +empties = find(cellfun('isempty',xref_rxnMetaCyc(:,1))); +xref_rxnMetaCyc(empties,:) = []; + +%load metaCycRxns.mat via getRxnsFromMetaCyc from RAVEN directory +MetaCyc_rxnInfo = []; +try + MetaCyc_rxnInfo = getRxnsFromMetaCyc; +catch + warning('RAVEN repository is not cloned or added to MATLAB path, unable to use function getRxnsFromMetaCyc'); +end + +%Input rxnKEGGID into xref array +if ~isempty(MetaCyc_rxnInfo) %check if MetaCyc_rxnInfo is generated successfully + for i = 1:length(xref_rxnMetaCyc) + if isempty(xref_rxnMetaCyc{i,4}) + idx = find(ismember(MetaCyc_rxnInfo.rxns,xref_rxnMetaCyc(i,1))); + if idx~=0 + if ~isempty(MetaCyc_rxnInfo.rxnMiriams{idx}) + temp = cell2mat(MetaCyc_rxnInfo.rxnMiriams(idx)); + idx2 = find(ismember(temp.name,'kegg.reaction')); + if ~isempty(idx2) + xref_rxnMetaCyc(i,5) = temp.value(idx2); + end + end + end + end + end + + if size(xref_rxnMetaCyc,2) == 5 + %only retain mapped rxnKEGGID if model.rxnKEGGID is empty + empties = find(cellfun('isempty',xref_rxnMetaCyc(:,5))); + xref_rxnMetaCyc(empties,:) = []; + empties = find(~cellfun('isempty',xref_rxnMetaCyc(:,4))); + xref_rxnMetaCyc(empties,:) = []; + + %add rxnKEGGID into model + [~,idx] = ismember(xref_rxnMetaCyc(:,2),model.rxns); + idx = idx(idx~=0); + + for i = 1:length(idx) + model.rxnKEGGID(idx(i)) = xref_rxnMetaCyc(i,5); + end + else + xref_rxnMetaCyc(:) = []; %erase all cell array, since no KEGGID matched and added + end +else + warning('ID mapping with MetaCyc IDs unsuccessful as function getMetsFromMetaCyc cannot be used to generate MetaCyc_metInfo'); +end + +%map rxnMetaNetXID to rxnSEEDID via function mapIDsViaMNXref, then map rxnSEEDID to rxnKEGGID +xref_rxnSEED = mapIDsViaMNXref('rxns',model.rxnMetaNetXID,'MetaNetX','SEED'); +xref_rxnSEED(:,2) = model.rxns; %match rxnSEEDID with model.rxns +xref_rxnSEED(:,3) = model.rxnMetaNetXID; %match rxnSEEDID with model.rxnMetaNetXID +xref_rxnSEED(:,4) = model.rxnKEGGID; %match rxnSEEDID with model.rxnKEGGID +empties = find(cellfun('isempty',xref_rxnSEED(:,1))); +xref_rxnSEED(empties,:) = []; + +%download reactions.tsv from GitHub repository ModelSEED/ModelSEEDDatabase +try + websave('reactions.tsv','https://raw.githubusercontent.com/ModelSEED/ModelSEEDDatabase/dev/Biochemistry/reactions.tsv'); +catch + warning('reactions.tsv was not successfully downloaded, check if directory for reactions.tsv has changed on github.com/ModelSEED/ModelSEEDDatabase/Biochemistry'); +end +fileDir = dir('reactions.tsv'); + +if ~isempty(fileDir) %check if reactions.tsv is present in current directory + %load reactions.tsv + fid2 = fopen('reactions.tsv'); + format = repmat('%s ',1,22); + format = strtrim(format); + rxn_temp = textscan(fid2,format,'Delimiter','\t','HeaderLines',0); + for i = 1:length(rxn_temp) + SEED_rxnInfo(:,i) = rxn_temp{i}; + end + commentLines = startsWith(SEED_rxnInfo(:,1),'#'); + SEED_rxnInfo(commentLines,:) = []; + fclose(fid2); + + %Input rxnKEGGID into xref array + for i = 1:length(xref_rxnSEED) + if isempty(xref_rxnSEED{i,4}) + idx = find(ismember(SEED_rxnInfo(:,1),xref_rxnSEED(i,1))); + if idx~=0 + if ~isempty(SEED_rxnInfo{idx,13}) && contains(SEED_rxnInfo(idx,13),'KEGG') + temp_ID = extractBetween(SEED_rxnInfo(idx,13),'KEGG: ','|'); + xref_rxnSEED(i,5) = temp_ID; + end + end + end + end + + if size(xref_rxnSEED,2) == 5 + %only retain mapped rxnKEGGID if model.rxnKEGGID is empty + empties = find(cellfun('isempty',xref_rxnSEED(:,5))); + xref_rxnSEED(empties,:) = []; + empties = find(~cellfun('isempty',xref_rxnSEED(:,4))); + xref_rxnSEED(empties,:) = []; + + %add rxnKEGGID into model + [~,idx] = ismember(xref_rxnSEED(:,2),model.rxns); + idx = idx(idx~=0); + + for i = 1:length(idx) + model.rxnKEGGID(idx(i)) = xref_rxnSEED(i,5); + end + else + xref_rxnSEED(:) = []; %erase all cell array, since no KEGGID matched and added + end + delete('reactions.tsv'); +else + warning('ID mapping with modelSEED IDs unsuccessful as reactions.tsv is not found'); +end + +%% metKEGGID +%map metMetaNetXID to metKEGGID via function mapIDsViaMNXref +xref_metKEGG = mapIDsViaMNXref('mets',model.metMetaNetXID,'MetaNetX','KEGG'); +xref_metKEGG(:,2) = model.mets; %match metKEGGID with model.mets +xref_metKEGG(:,3) = model.metMetaNetXID; %match metKEGGID with model.metMetaNetXID +xref_metKEGG(:,4) = model.metKEGGID; %match metKEGGID with model.metKEGGID + +%only retain mapped metKEGGID if model.metKEGGID is empty +empties = find(cellfun('isempty',xref_metKEGG(:,1))); +xref_metKEGG(empties,:) = []; +empties = find(~cellfun('isempty',xref_metKEGG(:,4))); +xref_metKEGG(empties,:) = []; + +%add metKEGGID into model +[~,idx] = ismember(xref_metKEGG(:,2),model.mets); +idx = idx(idx~=0); + +for i = 1:length(idx) + if ~contains(xref_metKEGG(i,1),'G') %metKEGGID containing G not added, since it is not compatible with current SBML format + model.metKEGGID(idx(i)) = xref_metKEGG(i,1); + end +end + +%map metMetaNetXID to metMetaCycID via function mapIDsViaMNXref, then map metMetaCycID to metKEGGID +xref_metMetaCyc = mapIDsViaMNXref('mets',model.metMetaNetXID,'MetaNetX','MetaCyc'); +xref_metMetaCyc(:,2) = model.mets; %match metMetaCycID with model.mets +xref_metMetaCyc(:,3) = model.metMetaNetXID; %match metMetaCycID with model.metMetaNetXID +xref_metMetaCyc(:,4) = model.metKEGGID; %match metMetaCycID with model.metKEGGID +empties = find(cellfun('isempty',xref_metMetaCyc(:,1))); +xref_metMetaCyc(empties,:) = []; + +%load metaCycMets.mat via getMetsFromMetaCyc from RAVEN +MetaCyc_metInfo = []; +try + MetaCyc_metInfo = getMetsFromMetaCyc; +catch + warning('RAVEN repository is not cloned or added to MATLAB path, unable to use function getMetsFromMetaCyc'); +end + +%Input metKEGGID into xref array +if ~isempty(MetaCyc_metInfo) %check if MetaCyc_metInfo is generated successfully + for i = 1:length(xref_metMetaCyc) + if isempty(xref_metMetaCyc{i,4}) + idx = find(ismember(MetaCyc_metInfo.mets,xref_metMetaCyc(i,1))); + if idx~=0 + if ~isempty(MetaCyc_metInfo.keggid{idx}) + xref_metMetaCyc(i,5) = MetaCyc_metInfo.keggid(idx); + end + end + end + end + + if size(xref_metMetaCyc,2) == 5 + %only retain mapped metKEGGID if model.metKEGGID is empty + empties = find(cellfun('isempty',xref_metMetaCyc(:,5))); + xref_metMetaCyc(empties,:) = []; + empties = find(~cellfun('isempty',xref_metMetaCyc(:,4))); + xref_metMetaCyc(empties,:) = []; + + %add metKEGGID into model + [~,idx] = ismember(xref_metMetaCyc(:,2),model.mets); + idx = idx(idx~=0); + + for i = 1:length(idx) + if ~contains(xref_metMetaCyc(i,5),'G') %metKEGGID containing G not added, since it is not compatible with current SBML format + model.metKEGGID(idx(i)) = xref_metMetaCyc(i,5); + end + end + else + xref_metMetaCyc(:) = []; %erase all cell array, since no KEGGID matched and added + end +else + warning('ID mapping with MetaCyc IDs unsuccessful as function getMetsFromMetaCyc cannot be used to generate MetaCyc_metInfo'); +end + +%map metMetaNetXID to metSEEDID via function mapIDsViaMNXref, then map metSEEDID to metKEGGID +xref_metSEED = mapIDsViaMNXref('mets',model.metMetaNetXID,'MetaNetX','SEED'); +xref_metSEED(:,2) = model.mets; %match metSEEDID with model.mets +xref_metSEED(:,3) = model.metMetaNetXID; %match metSEEDID with model.metMetaNetXID +xref_metSEED(:,4) = model.metKEGGID; %match metSEEDID with model.metKEGGID +empties = find(cellfun('isempty',xref_metSEED(:,1))); +xref_metSEED(empties,:) = []; + +%download reactions.tsv from GitHub repository ModelSEED/ModelSEEDDatabase +try + websave('compounds.tsv','https://raw.githubusercontent.com/ModelSEED/ModelSEEDDatabase/dev/Biochemistry/compounds.tsv'); +catch + warning('compounds.tsv was not successfully downloaded, check if directory for compounds.tsv has changed on github.com/ModelSEED/ModelSEEDDatabase/Biochemistry'); +end +fileDir = dir('compounds.tsv'); + +if ~isempty(fileDir) %check if compounds.tsv is present in current directory + %load compounds.tsv + fid2 = fopen('compounds.tsv'); + format = repmat('%s ',1,21); + format = strtrim(format); + met_temp = textscan(fid2,format,'Delimiter','\t','HeaderLines',0); + for i = 1:length(met_temp) + SEED_metInfo(:,i) = met_temp{i}; + end + commentLines = startsWith(SEED_metInfo(:,1),'#'); + SEED_metInfo(commentLines,:) = []; + fclose(fid2); + + %Input metKEGGID into xref array + for i = 1:length(xref_metSEED) + if isempty(xref_metSEED{i,4}) + idx = find(ismember(SEED_metInfo(:,1),xref_metSEED(i,1))); + if idx~=0 + if ~isempty(SEED_metInfo{idx,19}) && contains(SEED_metInfo(idx,19),'KEGG') + temp_ID = extractBetween(SEED_metInfo(idx,19),'KEGG: ','|'); + if isempty(temp_ID) %KEGGID may be present at the end + temp_ID = extractAfter(SEED_metInfo(idx,19),'KEGG: '); + temp_ID = erase(temp_ID,'"'); + end + if contains(temp_ID,';') %if more than 1 ID recorded, take the 1st one by default + temp_ID = split(temp_ID,';',2); + temp_ID = temp_ID(1,1); + warning('check %s, may contain more than 1 metKEGGID',string(SEED_metInfo(idx,1))); + end + xref_metSEED(i,5) = temp_ID; + end + end + end + end + + if size(xref_metSEED,2) == 5 + %only retain mapped metKEGGID if model.metKEGGID is empty + empties = find(cellfun('isempty',xref_metSEED(:,5))); + xref_metSEED(empties,:) = []; + empties = find(~cellfun('isempty',xref_metSEED(:,4))); + xref_metSEED(empties,:) = []; + + %add metKEGGID into model + [~,idx] = ismember(xref_metSEED(:,2),model.mets); + idx = idx(idx~=0); + + for i = 1:length(idx) + if ~contains(xref_metSEED(i,5),'G') %metKEGGID containing G not added, since it is not compatible with current SBML format + model.metKEGGID(idx(i)) = xref_metSEED(i,5); + end + end + else + xref_metSEED(:) = []; %erase all cell array, since no KEGGID matched and added + end + delete('compounds.tsv'); +else + warning('ID mapping with modelSEED IDs unsuccessful as compounds.tsv is not found'); +end + +%Save model +cd .. +saveYeastModel(model); +cd modelCuration/ \ No newline at end of file diff --git a/ComplementaryScripts/modelCuration/mapMNXMID.m b/ComplementaryScripts/modelCuration/mapMNXMID.m new file mode 100644 index 00000000..e7d500b0 --- /dev/null +++ b/ComplementaryScripts/modelCuration/mapMNXMID.m @@ -0,0 +1,162 @@ +% This script maps metabolite IDs of different databases to find new MNXMID(s) +% +% Inputs: model +% +% New MNXMID(s) will only be added if 1 of the following 3 criteria is met: +% a) Both metKEGGID and metChEBIID is mapped to the same MNXMID +% b) Only metKEGGID mapped to MNXMID, metFormula of new MNXMID matches model.metFormula +% c) Only metChEBIID mapped to MNXMID, metFormula of new MNXMID matches model.metFormula +% +% Inputs: model +% +% Cheng Wei Quan (Eiden), 2020-05-08 + +%load model +cd .. +model = loadYeastModel; + +%Check for chem_prop.tsv in current directory +%If not available, file will be downloaded +downloadMNXdb('chem_prop',pwd) + +%Load MNXchem_prop.tsv file containing data on all compounds from MetaNetX database +fid = fopen('chem_prop.tsv'); +format = repmat('%s ',1,9); +format = strtrim(format); +met_temp = textscan(fid,format,'Delimiter','\t','HeaderLines',0); +for i = 1:length(met_temp) + MNXchem_prop(:,i) = met_temp{i}; +end +commentLines = startsWith(MNXchem_prop(:,1),'#'); +MNXchem_prop(commentLines,:) = []; %MNX_ID Description Formula Charge Mass InChI SMILES Source InChIKey +fclose(fid); + +%map metCheBIID to metMetaNetXID via function mapIDsViaMNXref +cd missingFields +temp = replace(model.metChEBIID,'CHEBI:',''); +xref_metMetaNetX = mapIDsViaMNXref('mets',temp,'ChEBI','MetaNetX'); +xref_metMetaNetX(:,2) = model.mets; %match MNXMID with model.mets +xref_metMetaNetX(:,3) = model.metChEBIID; %match MNXMID with model.metChEBIID +xref_metMetaNetX(:,4) = model.metMetaNetXID; %match MNXMID with model.metMetaNetXID + +%only retain mapped MNXMID if model.metMetaNetXID is empty +empties = find(cellfun('isempty',xref_metMetaNetX(:,1))); +xref_metMetaNetX(empties,:) = []; +empties = find(~cellfun('isempty',xref_metMetaNetX(:,4))); +xref_metMetaNetX(empties,:) = []; + +%map metKEGGID to metMetaNetXID via function mapIDsViaMNXref +xref_metMetaNetX_2 = mapIDsViaMNXref('mets',model.metKEGGID,'KEGG','MetaNetX'); +xref_metMetaNetX_2(:,2) = model.mets; %match MNXMID with model.mets +xref_metMetaNetX_2(:,3) = model.metKEGGID; %match MNXMID with model.metKEGGID +xref_metMetaNetX_2(:,4) = model.metMetaNetXID; %match MNXMID with model.metMetaNetXID + +%only retain mapped MNXMID if model.metMetaNetXID is empty +empties = find(cellfun('isempty',xref_metMetaNetX_2(:,1))); +xref_metMetaNetX_2(empties,:) = []; +empties = find(~cellfun('isempty',xref_metMetaNetX_2(:,4))); +xref_metMetaNetX_2(empties,:) = []; + +%check for cases in which MNXMID mapped via both metChEBIID and metKEGGID +%compile data required via indexing +[~,idx] = ismember(xref_metMetaNetX_2(:,2),xref_metMetaNetX(:,2)); +idx = idx(idx~=0); +matchKEGGChEBI(:,1) = xref_metMetaNetX(idx,2); %model.mets +matchKEGGChEBI(:,3) = xref_metMetaNetX(idx,1); %MNXMID mapped via metChEBIID +matchKEGGChEBI(:,4) = xref_metMetaNetX(idx,3); %model.metChEBIID + +[~,idx2] = ismember(matchKEGGChEBI(:,1),model.mets); +idx2 = idx2(idx2~=0); +matchKEGGChEBI(:,2) = model.metFormulas(idx2); %model.metFormulas + +[~,idx3] = ismember(matchKEGGChEBI(:,3),MNXchem_prop(:,1)); +matchKEGGChEBI(:,5) = {''}; +matchKEGGChEBI(idx3~=0,5) = MNXchem_prop(idx3(idx3~=0),3); %metFormula of MNXMID mapped via metChEBIID + +[~,idx4] = ismember(xref_metMetaNetX(:,2),xref_metMetaNetX_2(:,2)); +idx4 = idx4(idx4~=0); +matchKEGGChEBI(:,6) = xref_metMetaNetX_2(idx4,1); %MNXMID mapped via metKEGGID +matchKEGGChEBI(:,7) = xref_metMetaNetX_2(idx4,3); %model.metKEGGID + +[~,idx5] = ismember(matchKEGGChEBI(:,6),MNXchem_prop(:,1)); +idx5 = idx5(idx5~=0); +matchKEGGChEBI(:,8) = MNXchem_prop(idx5,3); %metFormula of MNXMID mapped via metKEGGID + +for i = 1:size(matchKEGGChEBI,1) + if ismember(matchKEGGChEBI(i,3),matchKEGGChEBI(i,6)) + %add MNXMID into model if both metKEGGID and metChEBIID is mapped to the same MNXMID + model.metMetaNetXID(idx2(i)) = matchKEGGChEBI(i,3); + matchKEGGChEBI(i,9) = join(['added',model.metMetaNetXID(idx2(i)),'into model']); + else + if ismember(matchKEGGChEBI(i,2),matchKEGGChEBI(i,5)) + %add MNXMID into model if MNXMID mapped via metChEBIID has same metFormula as model.metFormula + model.metMetaNetXID(idx2(i)) = matchKEGGChEBI(i,3); + matchKEGGChEBI(i,9) = join(['added',model.metMetaNetXID(idx2(i)),'into model']); + elseif ismember(matchKEGGChEBI(i,2),matchKEGGChEBI(i,8)) + %add MNXMID into model if MNXMID mapped via metKEGGID has same metFormula as model.metFormula + model.metMetaNetXID(idx2(i)) = matchKEGGChEBI(i,3); + matchKEGGChEBI(i,9) = join(['added',model.metMetaNetXID(idx2(i)),'into model']); + else + matchKEGGChEBI(i,9) = {'MNXMID not added'}; + end + end +end + +%check for cases in which MNXMID mapped via metChEBIID only +%compile data required via indexing +idx = find(~ismember(xref_metMetaNetX(:,2),xref_metMetaNetX_2(:,2))); +matchChEBI(:,1) = xref_metMetaNetX(idx,2); %model.mets +matchChEBI(:,3) = xref_metMetaNetX(idx,1); %MNXMID mapped via metChEBIID +matchChEBI(:,4) = xref_metMetaNetX(idx,3); %model.metChEBIID + +[~,idx2] = ismember(matchChEBI(:,1),model.mets); +idx2 = idx2(idx2~=0); +matchChEBI(:,2) = model.metFormulas(idx2); %model.metFormulas + +[~,idx3] = ismember(matchChEBI(:,3),MNXchem_prop(:,1)); +matchChEBI(:,5) = {''}; +matchChEBI(idx3~=0,5) = MNXchem_prop(idx3(idx3~=0),3); %metFormula of MNXMID mapped via metChEBIID + +for i = 1:size(matchChEBI,1) + if ismember(matchChEBI(i,2),matchChEBI(i,5)) + %add MNXMID into model if MNXMID mapped via metChEBIID has same metFormula as model.metFormula + model.metMetaNetXID(idx2(i)) = matchChEBI(i,3); + matchChEBI(i,6) = join(['added',model.metMetaNetXID(idx2(i)),'into model']); + else + matchChEBI(i,6) = {'MNXMID not added'}; + end +end + +%check for cases in which MNXMID mapped via metKEGGID only +%compile data required via indexing +idx = find(~ismember(xref_metMetaNetX_2(:,2),xref_metMetaNetX(:,2))); +matchKEGG(:,1) = xref_metMetaNetX_2(idx,2); %model.mets +matchKEGG(:,3) = xref_metMetaNetX_2(idx,1); %MNXMID mapped via metKEGGID +matchKEGG(:,4) = xref_metMetaNetX_2(idx,3); %model.metKEGGID + +[~,idx2] = ismember(matchKEGG(:,1),model.mets); +idx2 = idx2(idx2~=0); +matchKEGG(:,2) = model.metFormulas(idx2); %model.metFormulas + +[~,idx3] = ismember(matchKEGG(:,3),MNXchem_prop(:,1)); +matchKEGG(:,5) = {''}; +matchKEGG(idx3~=0,5) = MNXchem_prop(idx3(idx3~=0),3); %metFormula of MNXMID mapped via metKEGGID + +for i = 1:size(matchKEGG,1) + if ismember(matchKEGG(i,2),matchKEGG(i,5)) + %add MNXMID into model if MNXMID mapped via metChEBIID has same metFormula as model.metFormula + model.metMetaNetXID(idx2(i)) = matchKEGG(i,3); + matchKEGG(i,6) = join(['added',model.metMetaNetXID(idx2(i)),'into model']); + else + matchKEGG(i,6) = {'MNXMID not added'}; + end +end + +%Save model +cd .. +fileDir = dir('chem_prop.tsv'); +if ~isempty(fileDir) + delete('chem_prop.tsv'); +end +saveYeastModel(model); +cd modelCuration/ \ No newline at end of file diff --git a/ComplementaryScripts/modelCuration/modMetsandSmatrix.m b/ComplementaryScripts/modelCuration/modMetsandSmatrix.m new file mode 100644 index 00000000..27bb14d5 --- /dev/null +++ b/ComplementaryScripts/modelCuration/modMetsandSmatrix.m @@ -0,0 +1,214 @@ +% This script fixes unbalanced reaction in the model based on data from modMetsandSmatrix.tsv +% +% modMetsandSmatrix.tsv includes details on changes to current metFormula +% and metCharges as well modifications of S matrix coefficient, +% after manual curation of selected unbalanced reactions in the model +% +% Inputs: model and modMetsandSmatrix.tsv +% Note: functions checkMassChargeBalance.m and changerxn.m are required +% +% Cheng Wei Quan (Eiden), 2020-05-20 + +%Load model +cd .. +model = loadYeastModel; + +%Load modMetsandSmatrix.tsv +fid = fopen('../ComplementaryData/modelCuration/modMetsandSmatrix.tsv'); +format = repmat('%s ',1,14); +format = strtrim(format); +temp = textscan(fid,format,'Delimiter','\t','HeaderLines',0); +for i = 1:length(temp) + curationfile(:,i) = temp{i}; %use {} instead of () for cell array +end +commentLines = startsWith(curationfile(:,1),'#'); +curationfile(commentLines,:) = []; +fclose(fid); + +%Different data sets are 'bracketed' i.e. separated by % - use for indexing +brackets = startsWith(curationfile(:,1),'%'); +idx = find(brackets); +idx_mets = idx(1)+1:idx(2)-1; +idx_Smatrix = idx(2)+1:idx(3)-1; + +%Separate data into various cell arrays +updatemets = curationfile(idx_mets,1:11); +updateSmatrix = curationfile(idx_Smatrix,1:9); + +%Add 2 new metabolites to model +metList = {'trans-4-hydroxy-L-proline [cytoplasm]';'2,3-dihydroxy-3-methylbutanoate [cytoplasm]'}; +metFormula = {'C5H9NO3';'C5H9O4'}; +metCharge = {0;-1}; +metChEBIID = {'CHEBI:18072';'CHEBI:11424'}; +metKEGGID = {'C01157';'C04039'}; +metMetaNetXID = {'MNXM87584';'MNXM734'}; + +comps = split(metList, ' ['); +comps = comps(:,2); +comps = strrep(comps,']',''); +CONValldata = cat(2,model.compNames,model.comps); +[~,b] = ismember(comps,CONValldata(:,1)); +comps = CONValldata(b,2); + +for i = 1:length(metList) + cd otherChanges/ + newID = getNewIndex(model.mets); + cd ../ + mets(i) = strcat('s_',newID,'[',comps(i),']'); + model = addMetabolite(model,char(mets(i)), ... + 'metName',metList{i},'metFormula', ... + metFormula{i},'Charge',metCharge{i}, ... + 'ChEBIID',metChEBIID{i},'KEGGId',metKEGGID{i}); + %Manually add MetaNetXID as addMetabolite does not include it + met_idx = find(ismember(model.mets,mets(i))); + model.metMetaNetXID(met_idx) = metMetaNetXID(i); +end + +cd modelCuration/ + +%Modify the following rxns: +%r_0687: L-proline is replaced by trans-4-hydroxy-L-proline +model = changerxn(model, 'r_0687', '1-pyrroline-3-hydroxy-5-carboxylic&acid [cytoplasm] + 2 H+ [cytoplasm] + NADPH [cytoplasm] -> trans-4-hydroxy-L-proline [cytoplasm] + NADP(+) [cytoplasm]'); +%r_4577: 3-hydroxy-3-methyl-2-oxobutanoate is replaced by 2,3-dihydroxy-3-methylbutanoate +model = changerxn(model, 'r_4577', '3-methyl-2-oxobutanoate [cytoplasm] + H2O [cytoplasm] -> 2,3-dihydroxy-3-methylbutanoate [cytoplasm]'); +cd ../missingFields/ +model = addSBOterms(model); %Add SBO terms +cd ../modelCuration/ +model = rmfield(model,'grRules'); %remove field 'grRules' in model + +%Correction of metFormula and metCharges to balance equation +met = updatemets(:,1); +[~,idx_met] = ismember(met,model.mets); +modelR = ravenCobraWrapper(model); +metNames = modelR.metNames(idx_met); +currentFormula = updatemets(:,2); +newFormula = updatemets(:,3); +currentCharge = str2double(updatemets(:,4)); +newCharge = str2double(updatemets(:,5)); +MNXNotes = updatemets(:,11); +metResults{size(updatemets,1)*5,6} = []; +metResults(1,:) = [{'Metabolites'},{'Unbalanced reaction(s) before modification (UB)'},... + {'Unbalanced reaction after modification (UA)'},{'Number of UB'},... + {'Number of UA'},{'Number of balanced reactions'}]; + +for i = 1:length(metNames) + idx_met = find(ismember(modelR.metNames,metNames(i))); + currentmetFormula = model.metFormulas(idx_met); + currentmetCharges = model.metCharges(idx_met); + + for j = 1:length(idx_met) + %Preliminary check of metBalance/metCharges before change + idx_rxn = find(model.S(idx_met(j),:)); + rxn = model.rxns(idx_rxn); + MassChargeresults = checkMassChargeBalance(model,rxn); + + if isequal(currentmetFormula(j),newFormula(i)) + %no action required + elseif ~isequal(currentmetFormula(j),currentFormula(i)) && ismember(currentFormula(i),'[]') || isequal(currentmetFormula(j),currentFormula(i)) && ~ismember(newFormula(i),'[]') + model.metFormulas(idx_met(j)) = newFormula(i); + if ~contains(model.metNotes(idx_met(j)),'| metFormula curated (PR #222)') + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| metFormula curated (PR #222)']); + end + elseif ~isequal(currentmetFormula(j),currentFormula(i)) + warning('error with metFormula matching in modMetsandSmatrix.tsv for %s, idx_met: %d', string(metNames(i)), idx_met(j)); + end + + if isequal(currentmetCharges(j),newCharge(i)) + %no action required + elseif (isequal(currentmetCharges(j),currentCharge(i)) && ~isnan(newCharge(i))) || (ismissing(currentmetCharges(j)) && isnan(currentCharge(i)) && ~isnan(newCharge(i))) + model.metCharges(idx_met(j)) = newCharge(i); + if ~contains(model.metNotes(idx_met(j)),'| metCharge curated (PR #222)') + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| metCharge curated (PR #222)']); + end + elseif ~isequal(currentmetCharges(j),currentCharge(i)) && ~ismissing(currentmetCharges(j)) + warning('error with metCharges matching in modMetsandSmatrix.tsv for %s, idx_met: %d', string(metNames(i)), idx_met(j)); + end + + %Find rxns which are unbalanced before change + temp_rxn = MassChargeresults(:,1); + temp_notes = MassChargeresults(:,2); + temp_idx = find(~ismember(temp_notes,'pass')); + unbalancedrxnBefore = temp_rxn(temp_idx); + unbalancedNotes = temp_notes(temp_idx); + unbalancedBefore = length(find(~ismember(temp_notes,'pass'))); + + arrayidx = find(cellfun('isempty', metResults),1); + metResults(arrayidx,1) = cellstr(metNames(i)); + metResults(arrayidx,2) = {[unbalancedrxnBefore,unbalancedNotes]}; + metResults(arrayidx,4) = num2cell(unbalancedBefore); + end +end + +%Modification of H+/H2O/other metabolite coefficient to balance equation +met2 = updateSmatrix(:,1); +rxn2 = updateSmatrix(:,2); +[~,idx_met2] = ismember(met2,model.mets); +[~,idx_rxn2] = ismember(rxn2,model.rxns); +currentCoef = str2double(updateSmatrix(:,3)); +newCoef = str2double(updateSmatrix(:,4)); + +for i = 1:length(updateSmatrix) + currentmetCoef = model.S(idx_met2(i),idx_rxn2(i)); + if isequal(currentmetCoef,currentCoef(i)) && ~isnan(newCoef(i)) + model.S(idx_met2(i),idx_rxn2(i)) = newCoef(i); + model.rxnNotes(idx_rxn2(i)) = join([model.rxnNotes(idx_rxn2(i)),'| model.S(',... + cellstr(string(idx_met2(i))),',',cellstr(string(idx_rxn2(i))),') curated (PR #222)']); + model.rxnNotes(idx_rxn2(i)) = strrep(model.rxnNotes(idx_rxn2(i)),'( ','('); + model.rxnNotes(idx_rxn2(i)) = strrep(model.rxnNotes(idx_rxn2(i)),' )',')'); + model.rxnNotes(idx_rxn2(i)) = strrep(model.rxnNotes(idx_rxn2(i)),' , ',','); + elseif ~isequal(currentmetCoef,currentCoef(i)) + warning('error with metCoef matching in modMetsandSmatrix.tsv for %s, idx_rxn: %d', string(rxn2(i)), idx_rxn2(i)); + end +end + +%remove whitespace(s) when adding notes +model.metNotes(:) = strtrim(model.metNotes(:)); +model.rxnNotes(:) = strtrim(model.rxnNotes(:)); + +%Check of metFormula/metCharges after change (for updatemets) +for i = 1:length(metNames) + idx_met = find(ismember(modelR.metNames,metNames(i))); + for j = 1:length(idx_met) + idx_rxn = find(model.S(idx_met(j),:)); + rxn = model.rxns(idx_rxn); + MassChargeresults2 = checkMassChargeBalance(model,rxn); + + %Find rxns which are unbalanced after change + temp_rxn2 = MassChargeresults2(:,1); + temp_notes2 = MassChargeresults2(:,2); + temp_idx2 = find(~ismember(temp_notes2,'pass')); + unbalancedrxnAfter = temp_rxn2(temp_idx2); + unbalancedNotes2 = temp_notes2(temp_idx2); + unbalancedAfter = length(find(~ismember(temp_notes2,'pass'))); + + if isempty(unbalancedrxnAfter) + arrayidx = find(cellfun('isempty', metResults(:,3)),1); + metResults(arrayidx,3) = {'NIL'}; + metResults(arrayidx,5) = {0}; + netChange = str2double(string((metResults(arrayidx,4)))) - unbalancedAfter; + metResults(arrayidx,6) = num2cell(netChange); + else + arrayidx = find(cellfun('isempty', metResults(:,3)),1); + metResults(arrayidx,3) = {[unbalancedrxnAfter,unbalancedNotes2]}; + metResults(arrayidx,5) = num2cell(unbalancedAfter); + netChange = str2double(string((metResults(arrayidx,4)))) - unbalancedAfter; + metResults(arrayidx,6) = num2cell(netChange); + end + end +end + +%Check of metBalance/metCharges after change (for updateSmatrix) +metResults2{size(updateSmatrix,1),5} = []; +for i = 1:size(updateSmatrix,1) + rxn = updateSmatrix(i,2); + MassChargeresults2 = checkMassChargeBalance(model,rxn); + metResults2(i,:) = MassChargeresults2; +end + +%Remove leading '| ' in notes that were previously empty +model.rxnNotes = regexprep(model.rxnNotes,'^\| ',''); +model.metNotes = regexprep(model.metNotes,'^\| ',''); + +%Save model +cd .. +saveYeastModel(model); diff --git a/ComplementaryScripts/modelCuration/modifyID.m b/ComplementaryScripts/modelCuration/modifyID.m new file mode 100644 index 00000000..a4b04ec4 --- /dev/null +++ b/ComplementaryScripts/modelCuration/modifyID.m @@ -0,0 +1,205 @@ +% This script modifies reaction and metabolite IDs based on data from modifyID.tsv +% +% modifyID.tsv includes details on changes to current rxn/metIDs, addition of new +% rxn/metIDs or notation of alternative rxn/metIDs after manual curation of +% deprecated IDs and selected unbalanced reactions in the model +% +% Inputs: model and modify.tsv +% +% Cheng Wei Quan (Eiden), 2020-05-05 + +%Load model +cd .. +model = loadYeastModel; + +%Load modifyID.tsv files +fid = fopen('../ComplementaryData/modelcuration/modifyID.tsv'); +format = repmat('%s ',1,16); +format = strtrim(format); +temp = textscan(fid,format,'Delimiter','\t','HeaderLines',0); +for i = 1:length(temp) + curationfile(:,i) = temp{i}; %use {} instead of () for cell array +end +commentLines = startsWith(curationfile(:,1),'#'); +curationfile(commentLines,:) = []; +fclose(fid); + +%Different data sets are 'bracketed' i.e. separated by % - use for indexing +brackets = startsWith(curationfile(:,1),'%'); +idx = find(brackets); +idx_rxnID = idx(1)+1:idx(2)-1; +idx_metID = idx(2)+1:idx(3)-1; + +%Separate data into various cell arrays +modifyrxnID = curationfile(idx_rxnID,1:10); +modifymetID = curationfile(idx_metID,1:16); + +%% Update rxnMetaNetXID + +rxn = modifyrxnID(:,1); +currentID = modifyrxnID(:,2); +newID = modifyrxnID(:,3); +alternativeID = modifyrxnID(:,4); + +for i = 1:length(currentID) + idx_rxn = find(ismember(model.rxns,rxn(i))); + %Check for new ID, if present = replace current ID/add ID to model + %if blank = remove current ID in model + if ~ismember(newID(i),'[]') && contains(newID(i),'MNXR') + model.rxnMetaNetXID(idx_rxn) = newID(i); + model.rxnNotes(idx_rxn) = join([model.rxnNotes(idx_rxn),'| MetaNetX ID curated (PR #220)']); + elseif ismember(newID(i),'Blank') + model.rxnMetaNetXID(idx_rxn) = {''}; + model.rxnNotes(idx_rxn) = join([model.rxnNotes(idx_rxn),'| MetaNetX ID curated (PR #220)']); + elseif ~ismember(newID(i),'[]') && ~contains(newID(i),'MNXR') + warning('Check for error in %s under rxnID curation data of the tsv file', string(rxn(i))); + end + + %Check for alternative ID, if present = add to rxnNotes + if ~ismember(alternativeID(i),'[]') && contains(alternativeID(i),'MNXR') + model.rxnNotes(idx_rxn) = join([model.rxnNotes(idx_rxn),'| alternative MetaNetX ID',alternativeID(i),'(PR #220)']); + elseif ~ismember(alternativeID(i),'[]') && ~contains(alternativeID(i),'MNXR') + warning('Check for error in %s under rxnID curation data of the tsv file', string(rxn(i))); + end +end + +%% Update rxnKEGGID + +currentID = modifyrxnID(:,5); +newID = modifyrxnID(:,6); +alternativeID = modifyrxnID(:,7); + +for i = 1:length(currentID) + idx_rxn = find(ismember(model.rxns,rxn(i))); + %Check for new ID, if present = replace current ID/add ID to model + %if blank = remove current ID in model + if ~ismember(newID(i),'[]') && contains(newID(i),'R') + model.rxnKEGGID(idx_rxn) = newID(i); + model.rxnNotes(idx_rxn) = join([model.rxnNotes(idx_rxn),'| KEGG ID curated (PR #220)']); + elseif ismember(newID(i),'Blank') + model.rxnKEGGID(idx_rxn) = {''}; + model.rxnNotes(idx_rxn) = join([model.rxnNotes(idx_rxn),'| KEGG ID curated (PR #220)']); + elseif ~ismember(newID(i),'[]') && ~contains(newID(i),'R') + warning('Check for error in %s under rxnID curation data of the tsv file', string(rxn(i))); + end + + %Check for alternative ID, if present = add to rxnNotes + if ~ismember(alternativeID(i),'[]') && contains(alternativeID(i),'R') + model.rxnNotes(idx_rxn) = join([model.rxnNotes(idx_rxn),'| alternative KEGG ID',alternativeID(i),'(PR #220)']); + elseif ~ismember(alternativeID(i),'[]') && ~contains(alternativeID(i),'R') + warning('Check for error in %s under rxnID curation data of the tsv file', string(rxn(i))); + end +end + +%remove whitespace(s) when adding notes into rxnNotes +model.rxnNotes(:) = strtrim(model.rxnNotes(:)); + +%additional changes to rxnNames in r_2117, r_4254 and r_4255 +[~,idx] = ismember('r_4254',model.rxns); %rxnFormula: NADH [cytoplasm] + 2 oxygen [cytoplasm] + 2 nitric oxide [cytoplasm] -> H+ [cytoplasm] + NAD [cytoplasm] + 2 nitrate [cytoplasm] +model.rxnNames(idx) = {'nitric oxide, NADH2:oxygen oxidoreductase'}; +[~,idx] = ismember('r_4255',model.rxns); %rxnFormula: NADPH [cytoplasm] + 2 oxygen [cytoplasm] + 2 nitric oxide [cytoplasm] -> H+ [cytoplasm] + NADP(+) [cytoplasm] + 2 nitrate [cytoplasm] +model.rxnNames(idx) = {'nitric oxide, NADPH2:oxygen oxidoreductase'}; +[~,idx] = ismember('r_2117',model.rxns); %rxnFormula: L-phenylalanine [cytoplasm] + pyruvate [cytoplasm] <=> keto-phenylpyruvate [cytoplasm] + L-alanine [cytoplasm] +model.rxnECNumbers(idx) = {'2.6.1.58; 2.6.1.7'}; + +%% Update metMetaNetXID + +met = modifymetID(:,1); +[~,idx_met] = ismember(met,model.mets); +modelR = ravenCobraWrapper(model); +metNames = modelR.metNames(idx_met); +currentID = modifymetID(:,2); +newID = modifymetID(:,3); +alternativeID = modifymetID(:,4); + +for i = 1:length(metNames) + idx_met = find(ismember(modelR.metNames,metNames(i))); + %Check for new ID, replace current ID/add new ID into model + %if blank = remove current ID in model + for j = 1:length(idx_met) + if ~ismember(newID(i),'[]') && contains(newID(i),'MNXM') + model.metMetaNetXID(idx_met(j)) = newID(i); + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| MetaNetX ID curated (PR #220)']); + elseif ismember(newID(i),'Blank') + model.metMetaNetXID(idx_met(j)) = {''}; + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| MetaNetX ID curated (PR #220)']); + elseif ~ismember(newID(i),'[]') && ~contains(newID(i),'MNXM') + warning('Check for error in %s under metID curation data of the tsv file', string(met(i))); + end + + if ~ismember(alternativeID(i),'[]') && contains(alternativeID(i),'MNXM') + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| alternative MetaNetX ID',alternativeID(i),'(PR #220)']); + elseif ~ismember(alternativeID(i),'[]') && ~contains(alternativeID(i),'MNXM') + warning('Check for error in %s under metID curation data of the tsv file', string(met(i))); + end + end +end + +%% Update metKEGGID + +currentID = modifymetID(:,5); +newID = modifymetID(:,6); +alternativeID = modifymetID(:,7); + +for i = 1:length(metNames) + idx_met = find(ismember(modelR.metNames,metNames(i))); + %Check for new ID, replace current ID/add new ID into model + %if blank = remove current ID in model + for j = 1:length(idx_met) + if ~ismember(newID(i),'[]') && contains(newID(i),'C') + model.metKEGGID(idx_met(j)) = newID(i); + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| KEGG ID curated (PR #220)']); + elseif ismember(newID(i),'Blank') + model.metKEGGID(idx_met(j)) = {''}; + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| KEGG ID curated (PR #220)']); + elseif ~ismember(newID(i),'[]') && contains(newID(i),'G') + warning('new KEGGID %s not added as it contains G and does not fulfil SBML format', string(newID(i))); + elseif ~ismember(newID(i),'[]') && ~contains(newID(i),'C') + warning('Check for error in %s under metID curation data of the tsv file', string(met(i))); + end + + if ~ismember(alternativeID(i),'[]') && contains(alternativeID(i),'C') + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| alternative KEGG ID',alternativeID(i),'(PR #220)']); + elseif ~ismember(alternativeID(i),'[]') && ~contains(alternativeID(i),'C') + warning('Check for error in %s under metID curation data of the tsv file', string(met(i))); + end + end +end + +%% Update metChEBIID + +currentID = modifymetID(:,8); +newID = modifymetID(:,9); +alternativeID = modifymetID(:,10); + +for i = 1:length(metNames) + idx_met = find(ismember(modelR.metNames,metNames(i))); + %Check for new ID, replace current ID/add new ID into model + %if blank = remove current ID in model + for j = 1:length(idx_met) + if ~ismember(newID(i),'[]') && contains(newID(i),'CHEBI') + model.metChEBIID(idx_met(j)) = newID(i); + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| ChEBI curated (PR #220)']); + elseif ismember(newID(i),'Blank') + model.metChEBIID(idx_met(j)) = {''}; + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| ChEBI curated (PR #220)']); + elseif ~ismember(newID(i),'[]') && ~contains(newID(i),'CHEBI') + warning('Check for error in %s under metID curation data of the tsv file', string(met(i))); + end + + if ~ismember(alternativeID(i),'[]') && contains(alternativeID(i),'CHEBI') + model.metNotes(idx_met(j)) = join([model.metNotes(idx_met(j)),'| alternative ChEBI',alternativeID(i),'(PR #220)']); + elseif ~ismember(alternativeID(i),'[]') && ~contains(alternativeID(i),'CHEBI') + warning('Check for error in %s under metID curation data of the tsv file', string(met(i))); + end + end +end + +%remove whitespace(s) when adding notes into rxnNotes +model.metNotes(:) = strtrim(model.metNotes(:)); +% Remove leading '| ' in notes that were previously empty +model.rxnNotes = regexprep(model.rxnNotes,'^\| ',''); +model.metNotes = regexprep(model.metNotes,'^\| ',''); +%Save model +saveYeastModel(model); +cd modelCuration/ \ No newline at end of file diff --git a/ComplementaryScripts/modelTests/cobrapy-compliance.ipynb b/ComplementaryScripts/modelTests/cobrapy-compliance.ipynb new file mode 100644 index 00000000..88062177 --- /dev/null +++ b/ComplementaryScripts/modelTests/cobrapy-compliance.ipynb @@ -0,0 +1,353 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# cobrapy compliance\n", + "\n", + "Notebook for confirming that every field is preserved when the model is used with cobrapy." + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Using license file C:\\Users\\bejsab\\gurobi.lic\n", + "Academic license - for non-commercial use only\n" + ] + } + ], + "source": [ + "import cobra\n", + "model = cobra.io.read_sbml_model(\"../../ModelFiles/xml/yeastGEM.xml\")" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## 1. Metabolites" + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "\n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + "
Metabolite identifiers_0001[ce]
Name(1->3)-beta-D-glucan [cell envelope]
Memory address0x01b5797c4d48
FormulaC6H10O5
Compartmentce
In 3 reaction(s)\n", + " r_0005, r_1543, r_4048
" + ], + "text/plain": [ + "" + ] + }, + "execution_count": 2, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "model.metabolites[0]" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "0" + ] + }, + "execution_count": 3, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "model.metabolites[0].charge" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{'sbo': ['SBO:0000247'],\n", + " 'chebi': 'CHEBI:37671',\n", + " 'kegg.compound': 'C00965',\n", + " 'metanetx.chemical': 'MNXM6492'}" + ] + }, + "execution_count": 4, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "model.metabolites[0].annotation" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## 2. Reactions" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "\n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + "
Reaction identifierr_2112
Namekynurenine aminotransferase
Memory address0x01b57fc40f88
Stoichiometry\n", + "

s_1020[c] + s_1399[c] <=> s_0955[c] + s_2763[c]

\n", + "

L-kynurenine [cytoplasm] + pyruvate [cytoplasm] <=> L-alanine [cytoplasm] + kynurenic acid [cytoplasm]

\n", + "
GPRYJL060W
Lower bound-1000.0
Upper bound1000.0
\n", + " " + ], + "text/plain": [ + "" + ] + }, + "execution_count": 5, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "model.reactions.get_by_id(\"r_2112\")" + ] + }, + { + "cell_type": "code", + "execution_count": 6, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{'sbo': ['SBO:0000176'],\n", + " 'pubmed': '18205391',\n", + " 'ec-code': '2.6.1.7',\n", + " 'kegg.reaction': 'R01959',\n", + " 'metanetx.reaction': 'MNXR99596'}" + ] + }, + "execution_count": 6, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "model.reactions.get_by_id(\"r_2112\").annotation" + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{'Confidence Level': '3'}" + ] + }, + "execution_count": 7, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "model.reactions.get_by_id(\"r_2112\").notes" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## 3. Genes" + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "\n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + "
Gene identifierQ0045
NameCOX1
Memory address0x01b57f39ba48
FunctionalTrue
In 1 reaction(s)\n", + " r_0438
" + ], + "text/plain": [ + "" + ] + }, + "execution_count": 8, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "model.genes[0]" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# 4. Subsystems" + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "'sce00040 Pentose and glucuronate interconversions'" + ] + }, + "execution_count": 9, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "model.groups[4].name" + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{,\n", + " ,\n", + " ,\n", + " ,\n", + " ,\n", + " ,\n", + " ,\n", + " ,\n", + " ,\n", + " ,\n", + " ,\n", + " ,\n", + " ,\n", + " ,\n", + " }" + ] + }, + "execution_count": 10, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "model.groups[4].members" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "metadata": {}, + "outputs": [], + "source": [] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.7.6" + } + }, + "nbformat": 4, + "nbformat_minor": 4 +} diff --git a/ComplementaryScripts/modelTests/findDuplicatedRxns.m b/ComplementaryScripts/modelTests/findDuplicatedRxns.m new file mode 100644 index 00000000..94228dd4 --- /dev/null +++ b/ComplementaryScripts/modelTests/findDuplicatedRxns.m @@ -0,0 +1,27 @@ +function findDuplicatedRxns(model) +% findDuplicatedRxns +% Find and print reactions that have the same stoichiometry (forwards or +% backwards). +% +% Input: +% model genome-scale model +% +% Usage: findDuplicatedRxns(model) +% +% Benjamin J. Sanchez, 2020-04-27 +% + +model_r = ravenCobraWrapper(model); +for i = 1:length(model.rxns)-1 + for j = i+1:length(model.rxns) + if isequal(model.S(:,i),model.S(:,j)) || isequal(model.S(:,i),-model.S(:,j)) + printRxnFormula(model,model.rxns(i),true,true,true); + disp(['Name: ' model.rxnNames{i} ' - GPR: ' model_r.grRules{i} ' - LB=' num2str(model.lb(i)) ' - UB=' num2str(model.ub(i))]) + printRxnFormula(model,model.rxns(j),true,true,true); + disp(['Name: ' model.rxnNames{j} ' - GPR: ' model_r.grRules{j} ' - LB=' num2str(model.lb(j)) ' - UB=' num2str(model.ub(j))]) + disp(" ") + end + end +end + +end diff --git a/ComplementaryScripts/otherChanges/anaerobicModel.m b/ComplementaryScripts/otherChanges/anaerobicModel.m index abd703c2..2df41b1e 100644 --- a/ComplementaryScripts/otherChanges/anaerobicModel.m +++ b/ComplementaryScripts/otherChanges/anaerobicModel.m @@ -9,7 +9,7 @@ function model = anaerobicModel(model) -%1th change: Refit GAM and NGAM to exp. data, change biomass composition +%1st change: Refit GAM and NGAM to exp. data, change biomass composition GAM = 30.49; %Data from Nissen et al. 1997 P = 0.461; %Data from Nissen et al. 1997 NGAM = 0; %Refit done in Jouthen et al. 2012 @@ -17,13 +17,13 @@ model = changeGAM(model,GAM,NGAM); model = scaleBioMass(model,'protein',P,'carbohydrate'); -%2nd change: Removes the requirement of heme a in the biomass equation -% (not used under aerobic conditions) -mets = {'s_3714[c]','s_1198[c]','s_1203[c]','s_1207[c]','s_1212[c]'}; +%2nd change: Removes the requirement of heme a, NAD(PH), coenzyme A in the biomass equation +% (not used under anaerobic conditions) +mets = {'s_3714[c]','s_1198[c]','s_1203[c]','s_1207[c]','s_1212[c]','s_0529[c]'}; [~,met_index] = ismember(mets,model.mets); model.S(met_index,strcmp(model.rxns,'r_4598')) = 0; -%3st change: Changes media to anaerobic (no O2 uptake and allows sterol +%3rd change: Changes media to anaerobic (no O2 uptake and allows sterol % and fatty acid exchanges) model.lb(strcmp(model.rxns,'r_1992')) = 0; %O2 model.lb(strcmp(model.rxns,'r_1757')) = -1000; %ergosterol @@ -34,7 +34,7 @@ model.lb(strcmp(model.rxns,'r_2137')) = -1000; %ergosta-5,7,22,24(28)-tetraen-3beta-ol model.lb(strcmp(model.rxns,'r_2189')) = -1000; %oleate -%4rd change: Blocked pathways for proper glycerol production +%4th change: Blocked pathways for proper glycerol production %Block oxaloacetate-malate shuttle (not present in anaerobic conditions) model.lb(strcmp(model.rxns,'r_0713')) = 0; %Mithocondria model.lb(strcmp(model.rxns,'r_0714')) = 0; %Cytoplasm diff --git a/ComplementaryScripts/saveYeastModel.m b/ComplementaryScripts/saveYeastModel.m index c872e2cc..262ba228 100644 --- a/ComplementaryScripts/saveYeastModel.m +++ b/ComplementaryScripts/saveYeastModel.m @@ -36,6 +36,9 @@ function saveYeastModel(model,upDATE) model = addSBOterms(model); cd .. +%Save "proteins" ("fbc:name" in the xml file) = "geneNames" ("fbc:label" in the xml file): +model.proteins = model.geneNames; + %Check if model is a valid SBML structure: writeCbModel(model,'sbml','tempModel.xml'); [~,errors] = TranslateSBML('tempModel.xml'); diff --git a/ModelFiles/dependencies.txt b/ModelFiles/dependencies.txt index 25883c8c..f6540b4c 100644 --- a/ModelFiles/dependencies.txt +++ b/ModelFiles/dependencies.txt @@ -1,7 +1,7 @@ MATLAB 9.7.0.1190202 (R2019b) libSBML 5.17.0 -RAVEN_toolbox 2.3.1 -COBRA_toolbox 3.1 +RAVEN_toolbox 2.4.0 +COBRA_toolbox commit 8204bb7 SBML_level 3 SBML_version 1 fbc_version 2 diff --git a/ModelFiles/txt/yeastGEM.txt b/ModelFiles/txt/yeastGEM.txt index 9de932f3..957e5352 100644 --- a/ModelFiles/txt/yeastGEM.txt +++ b/ModelFiles/txt/yeastGEM.txt @@ -34,13 +34,13 @@ r_0037 s_0193[c] + s_0803[c] -> s_0526[c] + s_0794[c] YOR360C 0.00 1000.00 r_0038 s_0577[c] -> s_0158[c] + s_0722[c] + s_0794[c] YDR487C 0.00 1000.00 0.00 r_0039 s_0210[c] -> s_0211[c] + s_0803[c] YDR127W 0.00 1000.00 0.00 r_0040 s_0349[c] -> s_0210[c] + s_1322[c] YDR127W 0.00 1000.00 0.00 -r_0041 s_0231[er] + 2 s_0795[er] + s_1213[er] -> s_1208[er] + s_1445[er] YBR265W 0.00 1000.00 0.00 +r_0041 s_0231[er] + s_0795[er] + s_1213[er] -> s_1208[er] + s_1445[er] YBR265W 0.00 1000.00 0.00 r_0042 s_0551[c] + s_0803[c] + s_1360[c] -> s_0349[c] + s_1322[c] ( YBR249C or YDR035W ) 0.00 1000.00 0.00 r_0043 s_0215[c] + 0.5 s_1275[c] -> s_0212[c] ( YPL252C or YDR376W ) 0.00 1000.00 0.00 r_0044 s_0214[m] + s_0799[m] -> s_0157[m] + s_0460[m] ( YDR538W and YDR539W ) 0.00 1000.00 0.00 -r_0045 s_0222[c] + s_0803[c] -> s_0224[c] + s_0955[c] YLR231C 0.00 1000.00 0.00 +r_0045 s_0222[c] + s_0803[c] -> s_0224[c] + s_0794[c] + s_0955[c] YLR231C 0.00 1000.00 0.00 r_0057 s_0054[p] + s_1202[p] -> s_0257[p] + s_0801[p] + s_1206[p] YKR009C 0.00 1000.00 0.00 -r_0058 s_0224[c] + s_1275[c] -> s_0147[c] + s_0794[c] YJR025C 0.00 1000.00 0.00 +r_0058 s_0224[c] + s_1275[c] -> s_0147[c] YJR025C 0.00 1000.00 0.00 r_0059 s_0009[c] + s_1416[c] -> s_0217[c] + s_1413[c] YER175C 0.00 1000.00 0.00 r_0060 s_0009[c] <=> s_0165[c] + s_0803[c] YGL009C -1000.00 1000.00 0.00 r_0061 s_0009[c] + s_1198[c] -> s_0010[c] + s_0794[c] + s_1203[c] YCL018W 0.00 1000.00 0.00 @@ -54,17 +54,17 @@ r_0068 s_0180[c] + s_0734[c] -> s_0991[c] + s_1461[c] YGR019W 0.00 1000.00 r_0069 s_0264[c] + s_0803[c] -> s_0285[c] + s_1322[c] YCR053W 0.00 1000.00 0.00 r_0070 s_0290[m] + s_0807[m] -> s_0287[m] + s_0532[m] + s_0799[m] 0.00 1000.00 0.00 r_0072 s_0291[c] + s_0794[c] -> s_0234[c] + s_0456[c] YDL080C 0.00 1000.00 0.00 -r_0073 s_0279[c] + s_0803[c] <=> 2 s_0794[c] + s_1158[c] + s_1322[c] ( YLR410W or YOR163W ) -1000.00 1000.00 0.00 -r_0074 s_0279[c] + s_0434[c] + 2 s_0794[c] -> s_0263[c] + s_0394[c] + s_0803[c] YDR017C 0.00 1000.00 0.00 +r_0073 s_0279[c] + s_0803[c] <=> s_0794[c] + s_1158[c] + s_1322[c] ( YLR410W or YOR163W ) -1000.00 1000.00 0.00 +r_0074 s_0279[c] + s_0434[c] + s_0794[c] -> s_0263[c] + s_0394[c] YDR017C 0.00 1000.00 0.00 r_0075 s_0303[c] + s_1322[c] -> s_0383[c] + s_1422[c] YLR017W 0.00 1000.00 0.00 r_0076 s_0526[c] + s_0803[c] -> s_0543[c] + s_1322[c] ( YER037W or YGL224C ) 0.00 1000.00 0.00 r_0077 s_0803[c] + s_0849[c] -> s_0856[c] + s_1322[c] YOR155C 0.00 1000.00 0.00 r_0078 s_0803[c] + s_1545[c] -> s_1322[c] + s_1556[c] ( YER037W or YGL224C ) 0.00 1000.00 0.00 r_0079 s_0301[c] + s_0434[c] + s_0803[c] + s_0999[c] -> s_0302[c] + s_0394[c] + s_0794[c] + s_0991[c] + s_1322[c] YGR061C 0.00 1000.00 0.00 -r_0080 s_0306[c] + 2 s_0794[c] + s_1212[c] -> s_0322[c] + s_1207[c] ( YGL125W or YPL023C ) 0.00 1000.00 0.00 +r_0080 s_0306[c] + s_0794[c] + s_1212[c] -> s_0322[c] + s_1207[c] ( YGL125W or YPL023C ) 0.00 1000.00 0.00 r_0081 s_0799[m] + s_1005[m] + s_1464[m] -> s_0317[m] + s_0460[m] + s_0532[m] YDR232W 0.00 1000.00 0.00 -r_0082 s_0318[c] + s_0803[c] -> 2 s_0794[c] + s_1158[c] + s_1322[c] YOR163W 0.00 1000.00 0.00 -r_0083 s_0434[c] + s_0794[c] + s_1158[c] -> s_0318[c] + s_0394[c] YDR017C 0.00 1000.00 0.00 +r_0082 s_0318[c] + s_0803[c] -> s_0794[c] + s_1158[c] + s_1322[c] YOR163W 0.00 1000.00 0.00 +r_0083 s_0434[c] + s_1158[c] -> s_0318[c] + s_0394[c] YDR017C 0.00 1000.00 0.00 r_0084 s_0319[c] + s_0434[c] -> s_0304[c] + s_0394[c] + s_1322[c] YER183C 0.00 1000.00 0.00 r_0085 s_0323[c] + s_1012[c] -> s_1029[c] + s_1486[c] YER091C 0.00 1000.00 0.00 r_0086 s_1423[c] -> s_0311[c] + s_0803[c] YJR024C 0.00 1000.00 0.00 @@ -73,9 +73,9 @@ r_0088 s_0318[c] + 2 s_0794[c] + s_1322[c] <=> s_0263[c] + s_0803[c] YLR410W - r_0089 s_0318[c] + 2 s_0794[c] + s_1322[c] <=> s_0309[c] + s_0803[c] YLR410W -1000.00 1000.00 0.00 r_0090 s_0434[c] + s_0557[c] -> s_0394[c] + s_0442[c] + s_0794[c] ( YIL107C or YOL136C ) 0.00 1000.00 0.00 r_0091 s_0335[c] + s_0803[c] -> s_0340[c] + s_0794[c] ( YGR248W or YHR163W ) 0.00 1000.00 0.00 -r_0092 s_0333[c] + s_0803[c] <=> 2 s_0794[c] + s_1158[c] + s_1322[c] ( YLR410W or YOR163W ) -1000.00 1000.00 0.00 -r_0093 s_0333[c] + s_0434[c] + 2 s_0794[c] -> s_0309[c] + s_0394[c] + s_0803[c] YDR017C 0.00 1000.00 0.00 -r_0094 s_0955[c] + s_1368[c] -> s_0352[c] + s_0456[c] + s_0529[c] + 4 s_0794[c] 0.00 1000.00 0.00 +r_0092 s_0333[c] + s_0803[c] <=> s_0794[c] + s_1158[c] + s_1322[c] ( YLR410W or YOR163W ) -1000.00 1000.00 0.00 +r_0093 s_0333[c] + s_0434[c] + s_0794[c] -> s_0309[c] + s_0394[c] YDR017C 0.00 1000.00 0.00 +r_0094 s_0794[c] + s_0955[c] + s_1368[c] -> s_0352[c] + s_0456[c] + s_0529[c] 0.00 1000.00 0.00 r_0095 2 s_0359[c] -> s_0020[c] ( YGR087C or YLR044C or YLR134W ) 0.00 1000.00 0.00 r_0096 s_0146[m] + s_0799[m] + s_1214[m] -> s_0016[m] + s_1210[m] YLR355C 0.00 1000.00 0.00 r_0097 s_0799[m] + 2 s_1401[m] -> s_0146[m] + s_0460[m] (( YCL009C and YMR108W ) or YMR108W ) 0.00 1000.00 0.00 @@ -132,7 +132,7 @@ r_0151 s_0299[c] -> s_0403[c] + s_0725[c] YLR359W 0.00 1000.00 0.00 r_0152 s_0393[c] <=> s_0423[c] + s_0725[c] YLR359W -1000.00 1000.00 0.00 r_0153 s_0785[c] + s_0849[c] + s_0973[c] -> s_0393[c] + s_0739[c] + 2 s_0794[c] + s_1322[c] YNL220W 0.00 1000.00 0.00 r_0154 s_0298[c] + s_0434[c] -> s_0201[c] + s_0394[c] + s_0794[c] YKL001C 0.00 1000.00 0.00 -r_0155 s_0131[c] + s_0794[c] + s_0803[c] -> s_0389[c] YGR247W 0.00 1000.00 0.00 +r_0155 s_0131[c] + s_0803[c] -> s_0389[c] + s_0794[c] YGR247W 0.00 1000.00 0.00 r_0156 s_0779[c] + s_0955[c] -> s_1003[c] + s_1399[c] YFL030W 0.00 1000.00 0.00 r_0157 s_0434[c] + s_0955[c] + s_1582[c] -> s_0404[c] + s_0423[c] + s_0633[c] YOR335C 0.00 1000.00 0.00 r_0158 s_0169[c] + s_0373[c] -> s_0172[c] + s_0529[c] ( YGR177C or YOR377W ) 0.00 1000.00 0.00 @@ -169,7 +169,7 @@ r_0188 s_0346[c] + 3 s_0803[c] -> s_0343[c] + 2 s_0794[c] + 3 s_1322[c] YDR481 r_0189 s_0405[c] + s_0803[c] <=> s_1552[c] + s_1555[c] YIR029W -1000.00 1000.00 0.00 r_0190 s_0407[c] + s_0803[c] <=> s_0405[c] + s_0794[c] YIR027C -1000.00 1000.00 0.00 r_0191 3 s_0794[c] + s_0803[c] + s_1554[c] -> 2 s_0419[c] + 2 s_0456[c] YBR208C 0.00 1000.00 0.00 -r_0192 s_0444[g] + s_0744[g] -> s_0414[g] + s_0740[g] + s_0797[g] ( YBR199W or YBR205W or YDR483W or YJL139C or YKR061W or YNL029C or YOR099W or YPL053C ) 0.00 1000.00 0.00 +r_0192 s_0444[g] + s_0744[g] + s_0797[g] -> s_0414[g] + s_0740[g] ( YBR199W or YBR205W or YDR483W or YJL139C or YKR061W or YNL029C or YOR099W or YPL053C ) 0.00 1000.00 0.00 r_0193 s_0810[v] + s_1522[v] -> 2 s_0566[v] ( YPR026W or YBR001C ) 0.00 1000.00 0.00 r_0194 s_0803[c] + s_1520[c] -> 2 s_0563[c] YDR001C 0.00 1000.00 0.00 r_0195 s_0568[c] + s_1543[c] -> s_0409[c] + s_0794[c] + s_1538[c] (( YBR126C and YDR074W and YML100W ) or ( YBR126C and YDR074W and YMR261C )) 0.00 1000.00 0.00 @@ -203,23 +203,23 @@ r_0224 s_0739[c] + s_0785[c] + s_0794[c] -> s_1283[c] + s_1322[c] YCL050C 0. r_0225 s_0434[c] + s_1386[c] -> s_0326[c] + s_0633[c] YER055C 0.00 1000.00 0.00 r_0226 s_0397[m] + 3 s_0794[c] + s_1326[m] -> s_0437[m] + 2 s_0799[m] + s_0807[m] (( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YPR020W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YJL180C and YLR393W and YNL315C and YOL077W-A and YCL005W-A )) 0.00 1000.00 0.00 r_0227 s_0434[c] + s_0803[c] -> s_0394[c] + s_0796[e] + s_1322[c] (( YCR024C-A and YEL017C-A and YGL008C ) or ( YCR024C-A and YEL017C-A and YPL036W ) or YER005W ) 0.00 1000.00 0.00 -r_0228 s_0743[c] + s_1184[c] -> s_0443[c] + s_0739[c] YBR110W 0.00 1000.00 0.00 +r_0228 s_0743[c] + s_1184[c] -> s_0443[c] + s_0739[c] + s_0794[c] YBR110W 0.00 1000.00 0.00 r_0229 s_0612[c] + s_1371[c] <=> s_0451[c] + 2 s_0794[c] YGR286C -1000.00 1000.00 0.00 r_0230 s_0434[c] + s_0451[c] + s_0794[c] -> s_0453[c] + s_0633[c] YDL141W 0.00 1000.00 0.00 r_0231 s_0262[c] + s_0794[c] + s_1212[c] -> s_0122[c] + s_1207[c] YNL280C 0.00 1000.00 0.00 r_0233 s_0664[c] + s_0794[c] + s_1212[c] + s_1275[c] -> s_0662[c] + 2 s_0803[c] + s_1207[c] YMR015C 0.00 1000.00 0.00 -r_0234 s_1207[c] + s_1578[c] -> s_0456[c] + s_0794[c] + s_1212[c] + s_1579[c] YGL001C 0.00 1000.00 0.00 -r_0235 s_0297[c] + s_1198[c] -> s_0209[c] + s_0456[c] + s_0794[c] + s_1203[c] YGL001C 0.00 1000.00 0.00 +r_0234 s_1207[c] + s_1578[c] -> s_0456[c] + s_1212[c] + s_1579[c] YGL001C 0.00 1000.00 0.00 +r_0235 s_0297[c] + s_1198[c] -> s_0209[c] + s_0456[c] + s_1203[c] YGL001C 0.00 1000.00 0.00 r_0236 s_0209[c] + s_0794[c] + s_1212[c] -> s_0296[c] + s_1207[c] YLR100W 0.00 1000.00 0.00 r_0237 s_0794[c] + s_1212[c] + s_1579[c] -> s_1207[c] + s_1569[c] YLR100W 0.00 1000.00 0.00 r_0238 s_0296[c] + s_0794[c] + s_1212[c] + s_1275[c] -> s_0803[c] + s_1207[c] + s_1576[c] YGR060W 0.00 1000.00 0.00 r_0239 s_0794[c] + s_1212[c] + s_1275[c] + s_1576[c] -> 2 s_0803[c] + s_1207[c] + s_1577[c] YGR060W 0.00 1000.00 0.00 -r_0240 s_0794[c] + s_1212[c] + s_1275[c] + s_1577[c] -> s_0803[c] + s_1207[c] + s_1578[c] YGR060W 0.00 1000.00 0.00 -r_0241 s_0122[c] + 3 s_0794[c] + 3 s_1212[c] + 3 s_1275[c] -> s_0297[c] + 4 s_0803[c] + 3 s_1207[c] YGR060W 0.00 1000.00 0.00 +r_0240 s_1212[c] + s_1275[c] + s_1577[c] -> s_0803[c] + s_1207[c] + s_1578[c] YGR060W 0.00 1000.00 0.00 +r_0241 s_0122[c] + 2 s_0794[c] + 3 s_1212[c] + 3 s_1275[c] -> s_0297[c] + 4 s_0803[c] + 3 s_1207[c] YGR060W 0.00 1000.00 0.00 r_0242 s_0657[c] + s_0794[c] + s_1212[c] + s_1275[c] -> s_0664[c] + 2 s_0803[c] + s_1207[c] YLR056W 0.00 1000.00 0.00 r_0243 s_0700[c] -> s_0657[c] YMR202W 0.00 1000.00 0.00 r_0244 s_0663[er] + s_0795[er] + s_1213[er] -> s_0667[er] + s_1208[er] YGL012W 0.00 1000.00 0.00 -r_0249 s_0286[c] + s_1231[c] <=> s_0633[c] + 2 s_0794[c] + s_1230[c] ( YDL090C and YKL019W ) -1000.00 1000.00 0.00 +r_0249 s_0286[c] + s_1231[c] <=> s_0633[c] + s_1230[c] ( YDL090C and YKL019W ) -1000.00 1000.00 0.00 r_0250 2 s_0434[c] + s_0445[c] + s_0803[c] + s_0999[c] -> 2 s_0394[c] + s_0455[c] + 2 s_0794[c] + s_0991[c] + s_1322[c] ( YJL130C and YJR109C and YOR303W ) 0.00 1000.00 0.00 r_0252 s_0021[c] + s_0373[c] -> s_0529[c] + s_1235[c] ( YAR035W or YER024W ) 0.00 1000.00 0.00 r_0253 s_0024[p] + s_0378[p] -> s_0534[p] + s_1237[p] YML042W 0.00 1000.00 0.00 @@ -275,13 +275,13 @@ r_0308 s_0803[c] + s_0980[c] -> s_0419[c] + s_1012[c] + s_1399[c] ( YFR055W or r_0309 s_1012[c] + s_1039[c] -> s_0803[c] + s_0980[c] YGR155W 0.00 1000.00 0.00 r_0310 s_0803[c] + s_0980[c] -> s_0178[c] + s_0419[c] + s_0981[c] YAL012W 0.00 1000.00 0.00 r_0311 s_0981[c] + s_1233[c] -> s_0362[c] + s_0794[c] + s_0980[c] YJR130C 0.00 1000.00 0.00 -r_0312 s_0841[c] + s_1234[c] -> s_0362[c] + s_0794[c] + s_0981[c] YLR303W 0.00 1000.00 0.00 +r_0312 s_0841[c] + s_1234[c] -> s_0362[c] + s_0981[c] YLR303W 0.00 1000.00 0.00 r_0313 s_0434[c] + s_0981[c] + s_1589[c] -> s_0423[c] + s_0542[c] + s_0633[c] YNL247W 0.00 1000.00 0.00 r_0314 s_0543[c] + s_0794[c] + s_0803[c] -> s_0419[c] + s_1556[c] YLR245C 0.00 1000.00 0.00 r_0315 s_0543[c] + s_0785[c] -> s_0526[c] + s_0739[c] + s_0794[c] YNR012W 0.00 1000.00 0.00 r_0317 2 s_0794[c] + s_1059[c] + 3 s_1212[c] + 3 s_1275[c] -> s_0262[c] + s_0722[c] + 4 s_0803[c] + 3 s_1207[c] ( YHR007C and YHR042W ) 0.00 1000.00 0.00 r_0318 s_0545[c] + s_0794[c] + s_0803[c] -> s_0419[c] + s_1550[c] YPR062W 0.00 1000.00 0.00 -r_0319 s_0547[c] + s_1275[c] <=> s_0607[c] + s_0837[c] YML086C -1000.00 1000.00 0.00 +r_0319 s_0547[c] + s_1275[c] <=> s_0607[c] + s_0794[c] + s_0837[c] YML086C -1000.00 1000.00 0.00 r_0320 s_0548[c] + s_1198[c] -> s_0547[c] + s_0794[c] + s_1203[c] YMR041C 0.00 1000.00 0.00 r_0321 s_0548[c] + s_1207[c] -> s_0547[c] + s_0794[c] + s_1212[c] YBR149W 0.00 1000.00 0.00 r_0322 s_0556[c] <=> s_0570[c] + s_0629[c] YKL060C -1000.00 1000.00 0.00 @@ -295,10 +295,10 @@ r_0331 s_0803[c] + s_1439[c] + s_1537[m] -> s_0274[c] + s_1526[c] + s_1535[m] r_0332 s_0152[c] + s_0434[c] -> s_0153[c] + s_0394[c] + s_0794[c] YCR036W 0.00 1000.00 0.00 r_0334 s_0200[m] + s_0437[m] -> s_0397[m] + s_0532[m] + s_0799[m] YDR196C 0.00 1000.00 0.00 r_0335 s_0341[c] + s_0434[c] + s_0456[c] <=> s_0394[c] + s_0612[c] + 3 s_0794[c] + s_1322[c] YNR057C -1000.00 1000.00 0.00 -r_0340 s_1085[er] + s_1445[er] <=> s_0475[er] YPL087W -1000.00 1000.00 0.00 -r_0341 s_0507[er] + s_1445[er] <=> s_0478[er] YPL087W -1000.00 1000.00 0.00 -r_0342 s_0481[er] -> s_1085[er] + s_1366[er] YPL087W 0.00 1000.00 0.00 -r_0343 s_0484[er] -> s_0507[er] + s_1366[er] YPL087W 0.00 1000.00 0.00 +r_0340 s_1085[er] + s_1445[er] <=> s_0475[er] + s_0804[er] YPL087W -1000.00 1000.00 0.00 +r_0341 s_0507[er] + s_1445[er] <=> s_0478[er] + s_0804[er] YPL087W -1000.00 1000.00 0.00 +r_0342 s_0481[er] + s_0804[er] -> s_1085[er] + s_1366[er] YPL087W 0.00 1000.00 0.00 +r_0343 s_0484[er] + s_0804[er] -> s_0507[er] + s_1366[er] YPL087W 0.00 1000.00 0.00 r_0344 s_0625[c] + s_0794[c] + s_1212[c] -> s_1207[c] + s_1487[c] YOR236W 0.00 1000.00 0.00 r_0345 s_0626[m] + s_0799[m] + s_1214[m] -> s_1210[m] + s_1488[m] YOR236W 0.00 1000.00 0.00 r_0346 s_0347[c] + s_0434[c] + s_0991[c] -> s_0394[c] + s_0625[c] + s_0794[c] + s_1322[c] YMR113W 0.00 1000.00 0.00 @@ -312,12 +312,12 @@ r_0353 s_0008[m] -> s_0060[m] + s_0807[m] YJR016C 0.00 1000.00 0.00 r_0354 s_0434[c] + s_0771[c] -> s_0394[c] + s_0629[c] + s_0794[c] ( YFL053W or YML070W ) 0.00 1000.00 0.00 r_0355 s_0943[c] + s_1376[c] -> s_0633[c] + s_0745[c] YJL167W 0.00 1000.00 0.00 r_0356 s_0075[c] <=> s_0140[c] + s_0794[c] YKL152C -1000.00 1000.00 0.00 -r_0357 s_0309[c] + 3 s_0803[c] -> 6 s_0794[c] + s_1156[c] + 3 s_1322[c] YOR163W 0.00 1000.00 0.00 -r_0358 s_0434[c] + 5 s_0794[c] + s_1156[c] + 2 s_1322[c] -> s_0309[c] + s_0394[c] + 2 s_0803[c] YDR017C 0.00 1000.00 0.00 +r_0357 s_0309[c] + 3 s_0803[c] -> 3 s_0794[c] + s_1156[c] + 3 s_1322[c] YOR163W 0.00 1000.00 0.00 +r_0358 s_0434[c] + 2 s_0794[c] + s_1156[c] + 2 s_1322[c] -> s_0309[c] + s_0394[c] + 2 s_0803[c] YDR017C 0.00 1000.00 0.00 r_0359 s_0143[c] + s_1416[c] -> s_0144[c] + s_0794[c] + s_1413[c] YLR172C 0.00 1000.00 0.00 -r_0360 s_0539[c] + s_0642[c] -> s_0467[c] + s_0645[c] + s_0794[c] YMR013C 0.00 1000.00 0.00 -r_0361 s_0645[c] + s_0743[c] -> s_0644[er] + s_0739[c] YPR183W 0.00 1000.00 0.00 -r_0362 s_0644[er] -> s_0646[er] + s_0795[er] + s_1108[er] (( YAL023C and YDL095W ) or YDL093W or YJR143C or YOR321W ) 0.00 1000.00 0.00 +r_0360 s_0539[c] + s_0642[c] + s_0794[c] -> s_0467[c] + s_0645[c] YMR013C 0.00 1000.00 0.00 +r_0361 s_0645[c] + s_0743[c] -> s_0644[er] + s_0739[c] + s_0794[c] YPR183W 0.00 1000.00 0.00 +r_0362 s_0644[er] -> s_0646[er] + s_1108[er] (( YAL023C and YDL095W ) or YDL093W or YJR143C or YOR321W ) 0.00 1000.00 0.00 r_0363 s_0434[c] + s_0649[c] -> s_0394[c] + s_0647[c] YJR057W 0.00 1000.00 0.00 r_0364 s_0656[c] + s_0803[c] -> s_0633[c] + s_0654[c] + s_0794[c] ( YJR069C or YBR252W ) 0.00 1000.00 0.00 r_0365 s_0805[e] + s_1309[e] -> s_0560[e] YJR153W 0.00 1000.00 0.00 @@ -336,8 +336,8 @@ r_0437 2 s_0710[m] + s_0838[m] -> 2 s_0709[m] + 2 s_0807[m] (( YEL039C and YKR r_0438 s_0710[m] + 1.266 s_0799[m] + 0.25 s_1278[m] -> s_0709[m] + 0.633 s_0794[c] + 0.5 s_0807[m] (( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YIL111W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YLR038C and YLR395C and YMR256C and YNL052W ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YIL111W and YJR048W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YJR048W and YLR038C and YLR395C and YMR256C and YNL052W ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YHR116W and YDR231C and YGR062C and YJL003W and YPL132W and YLL018C-A )) 0.00 1000.00 0.00 r_0439 2 s_0709[m] + 1.266 s_0799[m] + s_1535[m] -> 2 s_0710[m] + 2.532 s_0794[c] + s_1537[m] (( Q0105 and YBL045C and YDR529C and YEL024W and YEL039C and YFR033C and YGR183C and YHR001W-A and YJL166W and YOR065W and YPR191W ) or ( Q0105 and YBL045C and YDR529C and YEL024W and YFR033C and YGR183C and YHR001W-A and YJL166W and YJR048W and YOR065W and YPR191W )) 0.00 1000.00 0.00 r_0440 s_0434[c] + s_0714[c] + s_0794[c] -> s_0633[c] + s_0687[c] YDL045C 0.00 1000.00 0.00 -r_0441 s_0714[c] + s_0794[c] + s_1203[c] -> s_0717[c] + s_1198[c] YLR011W 0.00 1000.00 0.00 -r_0442 s_0714[c] + s_0794[c] + s_1212[c] -> s_0717[c] + s_1207[c] YLR011W 0.00 1000.00 0.00 +r_0441 s_0714[c] + 2 s_0794[c] + s_1203[c] -> s_0717[c] + s_1198[c] YLR011W 0.00 1000.00 0.00 +r_0442 s_0714[c] + 2 s_0794[c] + s_1212[c] -> s_0717[c] + s_1207[c] YLR011W 0.00 1000.00 0.00 r_0443 s_0721[c] + s_0750[c] + s_1198[c] -> s_0794[c] + s_1203[c] + s_1421[c] YDL168W 0.00 1000.00 0.00 r_0445 s_0722[c] + s_1198[c] -> s_0456[c] + s_1203[c] YOR388C 0.00 1000.00 0.00 r_0446 s_0434[c] + s_0722[c] + s_1487[c] <=> s_0120[c] + s_0394[c] + s_1322[c] YGR204W -1000.00 1000.00 0.00 @@ -348,8 +348,8 @@ r_0450 s_0555[c] <=> s_0629[c] + s_0764[c] YKL060C -1000.00 1000.00 0.00 r_0451 s_0727[m] + s_0807[m] <=> s_0068[m] YPL262W -1000.00 1000.00 0.00 r_0452 s_0725[c] + s_0803[c] <=> s_0066[c] YPL262W -1000.00 1000.00 0.00 r_0453 s_0061[c] + s_0725[c] -> s_1269[c] + s_1458[c] YKL216W 0.00 1000.00 0.00 -r_0454 s_0690[m] + s_0727[m] <=> s_0688[m] + s_1460[m] YEL047C -1000.00 1000.00 0.00 -r_0455 s_0689[c] + s_0725[c] <=> s_0687[c] + s_1458[c] YEL047C -1000.00 1000.00 0.00 +r_0454 s_0690[m] + s_0727[m] <=> s_0688[m] + s_0799[m] + s_1460[m] YEL047C -1000.00 1000.00 0.00 +r_0455 s_0689[c] + s_0725[c] <=> s_0687[c] + s_0794[c] + s_1458[c] YEL047C -1000.00 1000.00 0.00 r_0457 s_0750[c] + s_0955[c] -> s_0983[c] + s_0987[c] YLR299W 0.00 1000.00 0.00 r_0458 s_0434[c] + s_0558[c] -> s_0394[c] + s_0410[c] + s_0794[c] YBR020W 0.00 1000.00 0.00 r_0459 s_0410[c] + s_0794[c] + s_1559[c] -> s_0633[c] + s_1541[c] YBR018C 0.00 1000.00 0.00 @@ -382,7 +382,7 @@ r_0486 s_0764[c] + s_1198[c] + s_1322[c] <=> s_0075[c] + s_0794[c] + s_1203[c] r_0487 s_0765[c] + s_1207[c] -> s_0771[c] + s_0794[c] + s_1212[c] YOR120W 0.00 1000.00 0.00 r_0488 s_0434[c] + s_0765[c] -> s_0394[c] + s_0767[c] + s_0794[c] YHL032C 0.00 1000.00 0.00 r_0489 s_0767[c] + s_0803[c] -> s_0765[c] + s_1322[c] ( YER062C or YIL053W ) 0.00 1000.00 0.00 -r_0490 s_0688[m] + s_0770[m] -> s_0632[m] + s_0690[m] YIL155C 0.00 1000.00 0.00 +r_0490 s_0688[m] + s_0770[m] + s_0799[m] -> s_0632[m] + s_0690[m] YIL155C 0.00 1000.00 0.00 r_0491 s_0629[c] + s_0794[c] + s_1203[c] -> s_0767[c] + s_1198[c] ( YDL022W or YOL059W ) 0.00 1000.00 0.00 r_0492 s_0632[m] + s_0799[m] + s_1205[m] -> s_0770[m] + s_1200[m] YOL059W 0.00 1000.00 0.00 r_0497 s_0803[c] + s_1433[c] -> s_0512[c] + s_0767[c] + s_0794[c] YPL110C 0.00 1000.00 0.00 @@ -393,11 +393,11 @@ r_0502 s_1039[c] + s_1487[c] <=> s_0306[c] + s_0803[c] + s_1003[c] YLR058C -10 r_0503 s_1042[m] + s_1488[m] <=> s_0307[m] + s_0807[m] + s_1005[m] YBR263W -1000.00 1000.00 0.00 r_0504 s_0799[m] + s_1005[m] + s_1097[m] -> s_0460[m] + s_1409[m] ( YAL044C and YDR019C and YFL018C and YMR189W ) 0.00 1000.00 0.00 r_0505 s_0627[m] + s_1200[m] -> s_0799[m] + s_1097[m] + s_1205[m] (( YAL044C and YDR019C and YFL018C and YMR189W ) or ( YDR148C and YFL018C and YIL125W )) 0.00 1000.00 0.00 -r_0506 s_0799[m] + s_1005[m] + s_1098[m] -> s_0460[m] + s_1410[m] ( YAL044C and YDR019C and YFL018C and YMR189W ) 0.00 1000.00 0.00 -r_0507 s_1410[m] + s_1488[m] -> s_0307[m] + s_0421[m] + s_0628[m] ( YAL044C and YDR019C and YFL018C and YMR189W ) 0.00 1000.00 0.00 +r_0506 s_1005[m] + s_1098[m] -> s_0460[m] + s_1410[m] ( YAL044C and YDR019C and YFL018C and YMR189W ) 0.00 1000.00 0.00 +r_0507 s_0799[m] + s_1410[m] + s_1488[m] -> s_0307[m] + s_0421[m] + s_0628[m] ( YAL044C and YDR019C and YFL018C and YMR189W ) 0.00 1000.00 0.00 r_0508 s_0628[m] + s_1200[m] -> s_0799[m] + s_1098[m] + s_1205[m] ( YAL044C and YDR019C and YFL018C and YMR189W ) 0.00 1000.00 0.00 r_0509 s_1409[m] + s_1488[m] -> s_0307[m] + s_0421[m] + s_0627[m] ( YAL044C and YDR019C and YFL018C and YMR189W ) 0.00 1000.00 0.00 -r_0510 s_0803[c] + s_1543[c] -> s_0773[c] + s_0794[c] + s_1538[c] (( YFR015C and YJL137C ) or ( YFR015C and YKR058W ) or ( YJL137C and YLR258W ) or ( YKR058W and YLR258W )) 0.00 1000.00 0.00 +r_0510 s_1543[c] -> s_0773[c] + s_0794[c] + s_1538[c] (( YFR015C and YJL137C ) or ( YFR015C and YKR058W ) or ( YJL137C and YLR258W ) or ( YKR058W and YLR258W )) 0.00 1000.00 0.00 r_0511 s_0773[c] + s_1322[c] -> s_0567[c] YPR160W 0.00 1000.00 0.00 r_0512 s_0434[c] + s_1003[c] + s_1593[c] -> s_0423[c] + s_0633[c] + s_0757[c] ( YBR121C or YPR081C ) 0.00 1000.00 0.00 r_0514 s_0434[c] + s_0803[c] + s_0999[c] + s_1565[c] -> s_0423[c] + s_0633[c] + s_0782[c] + 2 s_0794[c] + s_0991[c] YMR217W 0.00 1000.00 0.00 @@ -417,7 +417,7 @@ r_0530 s_0812[m] + s_1205[m] + s_1278[m] -> s_0807[m] + s_0811[m] + s_1200[m] r_0531 s_0191[m] + s_0712[m] + s_0807[m] -> s_0636[m] + s_0812[m] YPL172C 0.00 1000.00 0.00 r_0532 s_0154[m] + s_0799[m] + s_1419[m] -> s_1415[m] + s_1535[m] ( YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C ) 0.00 1000.00 0.00 r_0533 s_0434[c] + s_0553[c] -> s_0394[c] + s_0557[c] + s_0794[c] ( YLR446W or YFR053C or YGL253W ) 0.00 1000.00 0.00 -r_0534 s_0434[c] + s_0563[c] -> s_0394[c] + s_0568[c] + s_0794[c] ( YLR446W or YCL040W or YFR053C or YGL253W ) 0.00 1000.00 0.00 +r_0534 s_0434[c] + s_0563[c] -> s_0394[c] + s_0568[c] + s_0794[c] ( YLR446W or YCL040W or YFR053C or YGL253W or YDR516C ) 0.00 1000.00 0.00 r_0535 s_0434[c] + s_0571[c] -> s_0394[c] + s_0574[c] + s_0794[c] ( YLR446W or YFR053C or YGL253W ) 0.00 1000.00 0.00 r_0536 s_0803[c] + s_1010[c] + 2 s_1198[c] -> 3 s_0794[c] + s_1006[c] + 2 s_1203[c] YCL030C 0.00 1000.00 0.00 r_0537 s_0803[c] + s_1011[c] -> s_1010[c] + s_1322[c] YFR025C 0.00 1000.00 0.00 @@ -428,14 +428,14 @@ r_0541 s_1006[c] + s_1416[c] -> s_0794[c] + s_1183[c] + s_1413[c] YBR034C 0. r_0542 s_0454[m] + s_0807[m] <=> s_0836[m] ( YJL200C or YDR234W ) -1000.00 1000.00 0.00 r_0543 s_0183[n] + s_0377[n] + s_0808[n] -> s_0533[n] + s_0800[n] + s_0835[n] ( YDL131W or YDL182W ) 0.00 1000.00 0.00 r_0544 s_1012[c] + s_1416[c] -> s_0794[c] + s_1029[c] + s_1413[c] ( YLL062C or YPL273W ) 0.00 1000.00 0.00 -r_0545 s_0836[m] + s_1200[m] -> s_0177[m] + s_0460[m] + s_0799[m] + s_1205[m] YIL094C 0.00 1000.00 0.00 +r_0545 s_0836[m] + s_1200[m] -> s_0177[m] + s_0460[m] + s_1205[m] YIL094C 0.00 1000.00 0.00 r_0546 s_0794[c] + s_0978[c] + s_1203[c] -> s_1014[c] + s_1198[c] YJR139C 0.00 1000.00 0.00 r_0547 s_0794[c] + s_0978[c] + s_1212[c] -> s_1014[c] + s_1207[c] YJR139C 0.00 1000.00 0.00 r_0548 s_0434[c] + s_1014[c] -> s_0394[c] + s_0794[c] + s_1238[c] YHR025W 0.00 1000.00 0.00 r_0549 s_0373[c] + s_1014[c] -> s_0529[c] + s_1233[c] YNL277W 0.00 1000.00 0.00 -r_0550 s_0837[c] + s_1616[c] -> 2 s_0803[c] + s_1620[c] (( YDR453C and YGR209C ) or ( YDR453C and YLR043C )) 0.00 1000.00 0.00 -r_0551 s_0838[m] + s_1617[m] -> 2 s_0807[m] + s_1621[m] ( YBL064C and YCR083W ) 0.00 1000.00 0.00 -r_0552 s_0840[p] + s_1619[p] -> 2 s_0809[p] + s_1623[p] (( YGR209C and YLR109W ) or ( YLR043C and YLR109W )) 0.00 1000.00 0.00 +r_0550 s_0794[c] + s_0837[c] + s_1616[c] -> 2 s_0803[c] + s_1620[c] (( YDR453C and YGR209C ) or ( YDR453C and YLR043C )) 0.00 1000.00 0.00 +r_0551 s_0799[m] + s_0838[m] + s_1617[m] -> 2 s_0807[m] + s_1621[m] ( YBL064C and YCR083W ) 0.00 1000.00 0.00 +r_0552 s_0801[p] + s_0840[p] + s_1619[p] -> 2 s_0809[p] + s_1623[p] (( YGR209C and YLR109W ) or ( YLR043C and YLR109W )) 0.00 1000.00 0.00 r_0553 s_0033[c] + s_0803[c] -> s_0025[c] + s_0750[c] + s_0794[c] YDR272W 0.00 1000.00 0.00 r_0554 s_0034[m] + s_0807[m] -> s_0027[m] + s_0752[m] + s_0799[m] YOR040W 0.00 1000.00 0.00 r_0555 s_0287[m] + s_0831[m] -> s_0216[m] + s_0636[m] YNR041C 0.00 1000.00 0.00 @@ -454,11 +454,11 @@ r_0567 s_0794[c] + s_0855[c] -> s_0456[c] + s_0850[c] ( YGR087C or YLR044C or r_0568 s_0633[c] + s_0803[c] -> s_0794[c] + 2 s_1322[c] YBR011C 0.00 1000.00 0.00 r_0569 s_0636[m] + s_0807[m] -> s_0799[m] + 2 s_1326[m] YMR267W 0.00 1000.00 0.00 r_0570 s_1365[c] <=> s_0803[c] + s_0849[c] ( YLR028C or YMR120C ) -1000.00 1000.00 0.00 -r_0571 s_0438[n] + s_0800[n] + s_1157[n] -> s_0398[n] + s_1159[n] YDR315C 0.00 1000.00 0.00 -r_0572 s_0123[n] + s_0438[n] + s_0800[n] -> s_0398[n] + s_1157[n] YDR173C 0.00 1000.00 0.00 -r_0573 s_0124[n] + s_0438[n] + s_0800[n] -> s_0398[n] + s_1157[n] YDR173C 0.00 1000.00 0.00 -r_0574 s_0125[n] + s_0438[n] + s_0800[n] -> s_0124[n] + s_0398[n] YDR173C 0.00 1000.00 0.00 -r_0575 s_0125[n] + s_0438[n] + s_0800[n] -> s_0123[n] + s_0398[n] YDR173C 0.00 1000.00 0.00 +r_0571 s_0438[n] + s_1157[n] -> s_0398[n] + s_0800[n] + s_1159[n] YDR315C 0.00 1000.00 0.00 +r_0572 s_0123[n] + s_0438[n] -> s_0398[n] + s_0800[n] + s_1157[n] YDR173C 0.00 1000.00 0.00 +r_0573 s_0124[n] + s_0438[n] -> s_0398[n] + s_0800[n] + s_1157[n] YDR173C 0.00 1000.00 0.00 +r_0574 s_0125[n] + s_0438[n] -> s_0124[n] + s_0398[n] + s_0800[n] YDR173C 0.00 1000.00 0.00 +r_0575 s_0125[n] + s_0438[n] -> s_0123[n] + s_0398[n] + s_0800[n] YDR173C 0.00 1000.00 0.00 r_0596 s_0804[er] + s_1116[er] -> s_0475[er] + s_1111[er] YER019W 0.00 1000.00 0.00 r_0597 s_0804[er] + s_1119[er] -> s_0478[er] + s_1111[er] YER019W 0.00 1000.00 0.00 r_0598 s_0804[er] + s_1128[er] -> s_0487[er] + s_1111[er] YER019W 0.00 1000.00 0.00 @@ -479,16 +479,16 @@ r_0612 s_0804[er] + s_0879[er] -> s_0493[er] + s_1109[er] YER019W 0.00 1000. r_0613 s_0804[er] + s_0882[er] -> s_0496[er] + s_1109[er] YER019W 0.00 1000.00 0.00 r_0614 s_0804[er] + s_0885[er] -> s_0499[er] + s_1109[er] YER019W 0.00 1000.00 0.00 r_0615 s_0804[er] + s_0888[er] -> s_0502[er] + s_1109[er] YER019W 0.00 1000.00 0.00 -r_0616 s_0807[m] + s_0896[m] -> s_0129[m] + s_0477[m] YER019W 0.00 1000.00 0.00 -r_0617 s_0807[m] + s_0899[m] -> s_0129[m] + s_0480[m] YER019W 0.00 1000.00 0.00 -r_0618 s_0807[m] + s_0908[m] -> s_0129[m] + s_0489[m] YER019W 0.00 1000.00 0.00 -r_0619 s_0807[m] + s_0911[m] -> s_0129[m] + s_0492[m] YER019W 0.00 1000.00 0.00 -r_0620 s_0807[m] + s_0902[m] -> s_0129[m] + s_0483[m] YER019W 0.00 1000.00 0.00 -r_0621 s_0807[m] + s_0905[m] -> s_0129[m] + s_0486[m] YER019W 0.00 1000.00 0.00 -r_0622 s_0807[m] + s_0914[m] -> s_0129[m] + s_0495[m] YER019W 0.00 1000.00 0.00 -r_0623 s_0807[m] + s_0917[m] -> s_0129[m] + s_0498[m] YER019W 0.00 1000.00 0.00 -r_0624 s_0807[m] + s_0920[m] -> s_0129[m] + s_0501[m] YER019W 0.00 1000.00 0.00 -r_0625 s_0807[m] + s_0923[m] -> s_0129[m] + s_0504[m] YER019W 0.00 1000.00 0.00 +r_0616 s_0807[m] + s_0896[m] -> s_0129[m] + s_0477[m] + 2 s_0799[m] YER019W 0.00 1000.00 0.00 +r_0617 s_0807[m] + s_0899[m] -> s_0129[m] + s_0480[m] + 2 s_0799[m] YER019W 0.00 1000.00 0.00 +r_0618 s_0807[m] + s_0908[m] -> s_0129[m] + s_0489[m] + 2 s_0799[m] YER019W 0.00 1000.00 0.00 +r_0619 s_0807[m] + s_0911[m] -> s_0129[m] + s_0492[m] + 2 s_0799[m] YER019W 0.00 1000.00 0.00 +r_0620 s_0807[m] + s_0902[m] -> s_0129[m] + s_0483[m] + 2 s_0799[m] YER019W 0.00 1000.00 0.00 +r_0621 s_0807[m] + s_0905[m] -> s_0129[m] + s_0486[m] + 2 s_0799[m] YER019W 0.00 1000.00 0.00 +r_0622 s_0807[m] + s_0914[m] -> s_0129[m] + s_0495[m] + 2 s_0799[m] YER019W 0.00 1000.00 0.00 +r_0623 s_0807[m] + s_0917[m] -> s_0129[m] + s_0498[m] + 2 s_0799[m] YER019W 0.00 1000.00 0.00 +r_0624 s_0807[m] + s_0920[m] -> s_0129[m] + s_0501[m] + 2 s_0799[m] YER019W 0.00 1000.00 0.00 +r_0625 s_0807[m] + s_0923[m] -> s_0129[m] + s_0504[m] + 2 s_0799[m] YER019W 0.00 1000.00 0.00 r_0626 s_0807[m] + s_1118[m] -> s_0477[m] + s_1112[m] YER019W 0.00 1000.00 0.00 r_0627 s_0807[m] + s_1121[m] -> s_0480[m] + s_1112[m] YER019W 0.00 1000.00 0.00 r_0628 s_0807[m] + s_1130[m] -> s_0489[m] + s_1112[m] YER019W 0.00 1000.00 0.00 @@ -509,16 +509,16 @@ r_0642 s_0807[m] + s_0881[m] -> s_0495[m] + s_1110[m] YER019W 0.00 1000.00 r_0643 s_0807[m] + s_0884[m] -> s_0498[m] + s_1110[m] YER019W 0.00 1000.00 0.00 r_0644 s_0807[m] + s_0887[m] -> s_0501[m] + s_1110[m] YER019W 0.00 1000.00 0.00 r_0645 s_0807[m] + s_0890[m] -> s_0504[m] + s_1110[m] YER019W 0.00 1000.00 0.00 -r_0646 s_0804[er] + s_0894[er] -> s_0127[er] + s_0475[er] YER019W 0.00 1000.00 0.00 -r_0647 s_0804[er] + s_0897[er] -> s_0127[er] + s_0478[er] YER019W 0.00 1000.00 0.00 -r_0648 s_0804[er] + s_0906[er] -> s_0127[er] + s_0487[er] YER019W 0.00 1000.00 0.00 -r_0649 s_0804[er] + s_0909[er] -> s_0127[er] + s_0490[er] YER019W 0.00 1000.00 0.00 -r_0650 s_0804[er] + s_0900[er] -> s_0127[er] + s_0481[er] YER019W 0.00 1000.00 0.00 -r_0651 s_0804[er] + s_0903[er] -> s_0127[er] + s_0484[er] YER019W 0.00 1000.00 0.00 -r_0652 s_0804[er] + s_0912[er] -> s_0127[er] + s_0493[er] YER019W 0.00 1000.00 0.00 -r_0653 s_0804[er] + s_0915[er] -> s_0127[er] + s_0496[er] YER019W 0.00 1000.00 0.00 -r_0654 s_0804[er] + s_0918[er] -> s_0127[er] + s_0499[er] YER019W 0.00 1000.00 0.00 -r_0655 s_0804[er] + s_0921[er] -> s_0127[er] + s_0502[er] YER019W 0.00 1000.00 0.00 +r_0646 s_0804[er] + s_0894[er] -> s_0127[er] + s_0475[er] + 2 s_0795[er] YER019W 0.00 1000.00 0.00 +r_0647 s_0804[er] + s_0897[er] -> s_0127[er] + s_0478[er] + 2 s_0795[er] YER019W 0.00 1000.00 0.00 +r_0648 s_0804[er] + s_0906[er] -> s_0127[er] + s_0487[er] + 2 s_0795[er] YER019W 0.00 1000.00 0.00 +r_0649 s_0804[er] + s_0909[er] -> s_0127[er] + s_0490[er] + 2 s_0795[er] YER019W 0.00 1000.00 0.00 +r_0650 s_0804[er] + s_0900[er] -> s_0127[er] + s_0481[er] + 2 s_0795[er] YER019W 0.00 1000.00 0.00 +r_0651 s_0804[er] + s_0903[er] -> s_0127[er] + s_0484[er] + 2 s_0795[er] YER019W 0.00 1000.00 0.00 +r_0652 s_0804[er] + s_0912[er] -> s_0127[er] + s_0493[er] + 2 s_0795[er] YER019W 0.00 1000.00 0.00 +r_0653 s_0804[er] + s_0915[er] -> s_0127[er] + s_0496[er] + 2 s_0795[er] YER019W 0.00 1000.00 0.00 +r_0654 s_0804[er] + s_0918[er] -> s_0127[er] + s_0499[er] + 2 s_0795[er] YER019W 0.00 1000.00 0.00 +r_0655 s_0804[er] + s_0921[er] -> s_0127[er] + s_0502[er] + 2 s_0795[er] YER019W 0.00 1000.00 0.00 r_0656 s_0803[c] + s_0927[c] -> s_0362[c] + s_0794[c] + s_0929[c] YOR126C 0.00 1000.00 0.00 r_0657 s_0803[c] + s_0935[c] -> s_0362[c] + s_0794[c] + s_0932[c] YOR126C 0.00 1000.00 0.00 r_0658 s_0941[m] + s_1200[m] -> s_0182[m] + s_0460[m] + s_1205[m] ( YNL037C and YOR136W ) 0.00 1000.00 0.00 @@ -545,7 +545,7 @@ r_0680 s_0805[e] + s_0970[e] -> s_0420[e] + s_0974[e] ( YLR155C or YLR157C or r_0681 s_0180[c] + s_0677[c] -> s_0282[c] + s_0991[c] YLR027C 0.00 1000.00 0.00 r_0682 s_0182[m] + s_0678[m] -> s_0283[m] + s_0993[m] YKL106W 0.00 1000.00 0.00 r_0683 s_0184[p] + s_0679[p] -> s_0284[p] + s_0995[p] YLR027C 0.00 1000.00 0.00 -r_0687 s_0116[c] + 2 s_0794[c] + s_1212[c] -> s_1035[c] + s_1207[c] YER023W 0.00 1000.00 0.00 +r_0687 s_0116[c] + 2 s_0794[c] + s_1212[c] -> s_1207[c] + s_4207[c] YER023W 0.00 1000.00 0.00 r_0688 s_0794[c] + s_1151[c] + s_1212[c] -> s_0062[c] + s_1207[c] ( YHR104W or YOL151W ) 0.00 1000.00 0.00 r_0689 s_1039[c] -> s_0419[c] + s_1399[c] YCL064C 0.00 1000.00 0.00 r_0690 s_1039[c] + s_1207[c] -> s_0794[c] + s_0960[c] + s_1212[c] YMR226C 0.00 1000.00 0.00 @@ -582,7 +582,7 @@ r_0723 s_0574[c] <=> s_0557[c] YER003C -1000.00 1000.00 0.00 r_0724 s_0305[m] + s_0807[m] <=> s_0121[m] + s_0799[m] YBR084W -1000.00 1000.00 0.00 r_0725 s_0304[c] + s_0803[c] <=> s_0120[c] + s_0794[c] YGR204W -1000.00 1000.00 0.00 r_0726 s_0434[c] + s_0803[c] + s_1029[c] -> s_0633[c] + s_1322[c] + s_1416[c] ( YDR502C or YLR180W ) 0.00 1000.00 0.00 -r_0727 s_0322[c] + s_1012[c] -> s_0794[c] + s_1029[c] + s_1487[c] YER091C 0.00 1000.00 0.00 +r_0727 s_0322[c] + s_1012[c] -> s_1029[c] + s_1487[c] YER091C 0.00 1000.00 0.00 r_0728 s_0121[m] + s_1149[m] -> s_0713[m] + s_0799[m] + s_1488[m] YBL013W 0.00 1000.00 0.00 r_0729 s_0434[c] + s_1029[c] + s_1602[c] -> s_0423[c] + s_0633[c] + s_1148[c] YGR264C 0.00 1000.00 0.00 r_0730 s_0437[m] + s_1031[m] + s_1603[m] -> s_0424[m] + s_0636[m] + s_1149[m] YGR171C 0.00 1000.00 0.00 @@ -595,16 +595,16 @@ r_0736 s_0028[c] + s_0539[c] -> s_0019[c] + s_0467[c] + s_0794[c] YMR208W 0. r_0737 s_0028[c] + s_0785[c] -> s_0019[c] + s_0739[c] + s_0794[c] YMR208W 0.00 1000.00 0.00 r_0738 s_0028[c] + s_1559[c] -> s_0019[c] + s_0794[c] + s_1538[c] YMR208W 0.00 1000.00 0.00 r_0739 s_0018[c] + s_0434[c] -> s_0394[c] + s_0456[c] + s_0943[c] + s_1322[c] YNR043W 0.00 1000.00 0.00 -r_0747 s_0744[g] + s_0895[g] -> s_0740[g] + s_1117[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 -r_0748 s_0744[g] + s_0898[g] -> s_0740[g] + s_1120[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 -r_0749 s_0744[g] + s_0907[g] -> s_0740[g] + s_1129[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 -r_0750 s_0744[g] + s_0910[g] -> s_0740[g] + s_1132[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 -r_0751 s_0744[g] + s_0901[g] -> s_0740[g] + s_1123[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 -r_0752 s_0744[g] + s_0904[g] -> s_0740[g] + s_1126[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 -r_0753 s_0744[g] + s_0913[g] -> s_0740[g] + s_1135[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 -r_0754 s_0744[g] + s_0916[g] -> s_0740[g] + s_1138[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 -r_0755 s_0744[g] + s_0919[g] -> s_0740[g] + s_1141[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 -r_0756 s_0744[g] + s_0922[g] -> s_0740[g] + s_1144[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 +r_0747 s_0744[g] + s_0895[g] -> s_0740[g] + s_0797[g] + s_1117[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 +r_0748 s_0744[g] + s_0898[g] -> s_0740[g] + s_0797[g] + s_1120[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 +r_0749 s_0744[g] + s_0907[g] -> s_0740[g] + s_0797[g] + s_1129[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 +r_0750 s_0744[g] + s_0910[g] -> s_0740[g] + s_0797[g] + s_1132[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 +r_0751 s_0744[g] + s_0901[g] -> s_0740[g] + s_0797[g] + s_1123[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 +r_0752 s_0744[g] + s_0904[g] -> s_0740[g] + s_0797[g] + s_1126[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 +r_0753 s_0744[g] + s_0913[g] -> s_0740[g] + s_0797[g] + s_1135[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 +r_0754 s_0744[g] + s_0916[g] -> s_0740[g] + s_0797[g] + s_1138[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 +r_0755 s_0744[g] + s_0919[g] -> s_0740[g] + s_0797[g] + s_1141[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 +r_0756 s_0744[g] + s_0922[g] -> s_0740[g] + s_0797[g] + s_1144[g] (( YBR036C and YBR161W ) or ( YBR036C and YPL057C )) 0.00 1000.00 0.00 r_0757 s_0126[c] + s_0803[c] -> s_1153[c] + s_1322[c] ( YDR287W or YHR046C ) 0.00 1000.00 0.00 r_0758 s_0568[c] -> s_0126[c] YJL153C 0.00 1000.00 0.00 r_0759 s_0799[m] + s_1191[m] + s_1214[m] -> s_0145[m] + s_1210[m] + s_1326[m] YER069W 0.00 1000.00 0.00 @@ -653,7 +653,7 @@ r_0807 s_0803[c] + s_0950[c] -> s_0794[c] + s_0846[c] + s_1322[c] YER005W 0. r_0810 s_0740[g] + s_0806[g] -> s_0783[g] + s_0797[g] + s_1325[g] YEL042W 0.00 1000.00 0.00 r_0811 s_0434[c] + s_1538[c] -> s_0394[c] + s_1559[c] YKL067W 0.00 1000.00 0.00 r_0812 s_1150[c] + s_1233[c] -> s_0362[c] + s_0794[c] + s_1029[c] YLR303W 0.00 1000.00 0.00 -r_0813 s_0841[c] + s_1233[c] -> s_0362[c] + s_0794[c] + s_1012[c] YLR303W 0.00 1000.00 0.00 +r_0813 s_0841[c] + s_1233[c] -> s_0362[c] + s_1012[c] YLR303W 0.00 1000.00 0.00 r_0815 s_0981[c] + s_1241[c] <=> s_0794[c] + s_0980[c] + s_1458[c] ( YLL058W or YML082W or YAL012W ) -1000.00 1000.00 0.00 r_0816 s_0455[c] + s_1266[c] -> s_0794[c] + s_0979[c] + s_1322[c] YJL088W 0.00 1000.00 0.00 r_0817 s_0794[c] + s_1266[c] -> s_0456[c] + s_1389[c] YKL184W 0.00 1000.00 0.00 @@ -676,9 +676,9 @@ r_0851 s_0180[c] + s_1032[c] <=> s_0951[c] + s_0991[c] YGL202W -1000.00 1000.0 r_0852 s_0434[c] + s_1032[c] + s_1604[c] -> s_0423[c] + s_0633[c] + s_1314[c] ( YFL022C and YLR060W ) 0.00 1000.00 0.00 r_0853 s_0437[m] + s_1034[m] + s_1605[m] -> s_0424[m] + s_0636[m] + s_1315[m] YPR047W 0.00 1000.00 0.00 r_0854 s_0794[c] + s_0951[c] -> s_0456[c] + s_1318[c] YDR380W 0.00 1000.00 0.00 -r_0855 s_0302[c] + s_0434[c] -> s_0300[c] + s_0394[c] + 2 s_0794[c] + s_1322[c] YGL234W 0.00 1000.00 0.00 +r_0855 s_0302[c] + s_0434[c] -> s_0300[c] + s_0394[c] + s_0794[c] + s_1322[c] YGL234W 0.00 1000.00 0.00 r_0882 s_1190[c] <=> s_1189[c] YEL058W -1000.00 1000.00 0.00 -r_0883 s_0201[c] + s_1616[c] -> s_0390[c] + 2 s_0794[c] + s_1469[c] + s_1620[c] (( YGR209C and YPR167C ) or ( YLR043C and YPR167C )) 0.00 1000.00 0.00 +r_0883 s_0201[c] + s_1616[c] -> s_0390[c] + s_0794[c] + s_1469[c] + s_1620[c] (( YGR209C and YPR167C ) or ( YLR043C and YPR167C )) 0.00 1000.00 0.00 r_0884 s_0434[c] + s_1271[c] -> s_0394[c] + s_0456[c] + s_1360[c] YKR097W 0.00 1000.00 0.00 r_0885 s_0539[c] + s_0794[c] + s_1239[c] -> s_0474[c] + s_0633[c] YGR007W 0.00 1000.00 0.00 r_0886 s_0434[c] + s_0557[c] -> s_0394[c] + s_0555[c] + s_0794[c] ( YMR205C or ( YGR240C and YMR205C )) 0.00 1000.00 0.00 @@ -695,10 +695,10 @@ r_0904 s_0019[c] + s_0434[c] -> s_0018[c] + s_0394[c] YMR220W 0.00 1000.00 r_0905 s_0017[c] + s_0539[c] + s_0981[c] -> s_0526[c] + s_0633[c] + s_0794[c] + s_1188[c] YIL083C 0.00 1000.00 0.00 r_0906 s_0794[c] + s_1188[c] -> s_0456[c] + s_1307[c] (( YKL088W and YKR072C and YOR054C ) or ( YKL088W and YKR072C ) or ( YKL088W and YOR054C ) or YKL088W ) 0.00 1000.00 0.00 r_0907 s_0415[c] <=> s_1408[c] ( YKL127W or YMR105C or YMR278W ) -1000.00 1000.00 0.00 -r_0908 s_0434[c] + s_0973[c] + s_1364[c] -> s_0299[c] + s_0394[c] + s_0794[c] + s_1322[c] YAR015W 0.00 1000.00 0.00 +r_0908 s_0434[c] + s_0973[c] + s_1364[c] -> s_0299[c] + s_0394[c] + 2 s_0794[c] + s_1322[c] YAR015W 0.00 1000.00 0.00 r_0909 s_0078[c] + s_0803[c] -> s_0077[c] YCL030C 0.00 1000.00 0.00 r_0910 s_0326[c] + s_0803[c] -> s_0078[c] + s_0633[c] + s_0794[c] YCL030C 0.00 1000.00 0.00 -r_0911 s_0300[c] + s_0434[c] + s_0456[c] + s_0803[c] -> s_0394[c] + s_0794[c] + s_1322[c] + s_1364[c] YOR128C 0.00 1000.00 0.00 +r_0911 s_0300[c] + s_0456[c] -> s_0794[c] + s_1364[c] YOR128C 0.00 1000.00 0.00 r_0912 s_0120[c] + s_0403[c] <=> s_1365[c] + s_1487[c] ( YLR028C or YMR120C ) -1000.00 1000.00 0.00 r_0913 s_1187[c] -> s_0076[c] YDR007W 0.00 1000.00 0.00 r_0914 s_0327[c] + s_0434[c] + s_1003[c] -> s_0325[c] + s_0394[c] + s_0794[c] + s_1322[c] YGL234W 0.00 1000.00 0.00 @@ -706,8 +706,8 @@ r_0915 s_0803[c] + s_0999[c] + s_1386[c] -> s_0327[c] + s_0633[c] + s_0991[c] r_0916 s_0434[c] + s_1408[c] -> s_0423[c] + s_0794[c] + s_1386[c] (( YKL181W and YER099C ) or ( YKL181W and YHL011C ) or ( YKL181W and YBL068W ) or ( YER099C and YOL061W ) or ( YBL068W and YOL061W )) 0.00 1000.00 0.00 r_0917 s_0259[c] + s_0803[c] -> s_1039[c] + s_1322[c] YGR208W 0.00 1000.00 0.00 r_0918 s_0258[c] + s_0991[c] -> s_0180[c] + s_0259[c] YOR184W 0.00 1000.00 0.00 -r_0919 s_1085[er] + s_1366[er] -> s_0481[er] YBR183W 0.00 1000.00 0.00 -r_0920 s_0507[er] + s_1366[er] -> s_0484[er] YDR402C 0.00 1000.00 0.00 +r_0919 s_1085[er] + s_1366[er] -> s_0481[er] + s_0804[er] YBR183W 0.00 1000.00 0.00 +r_0920 s_0507[er] + s_1366[er] -> s_0484[er] + s_0804[er] YDR402C 0.00 1000.00 0.00 r_0921 s_1367[er] -> s_0161[er] + s_1240[er] YDR294C 0.00 1000.00 0.00 r_0922 s_0795[er] + s_1213[er] + s_1276[er] + s_1445[er] -> s_0804[er] + s_1208[er] + s_1366[er] YDR297W 0.00 1000.00 0.00 r_0929 s_0803[c] + s_1180[c] + s_1275[c] -> s_0208[c] + s_0837[c] + s_1193[c] YMR020W 0.00 1000.00 0.00 @@ -717,7 +717,7 @@ r_0937 s_0803[c] + s_1275[c] + s_1442[c] -> s_0208[c] + s_0837[c] + s_1439[c] r_0938 s_0794[c] + s_1377[c] -> s_0456[c] + s_0803[c] + s_0951[c] YNL316C 0.00 1000.00 0.00 r_0939 s_1207[c] + s_1377[c] -> s_0204[c] + s_0456[c] + s_1212[c] YBR166C 0.00 1000.00 0.00 r_0940 s_0688[m] + s_1037[m] -> s_0119[m] + s_0690[m] YLR142W 0.00 1000.00 0.00 -r_0941 s_0434[c] + s_1035[c] + s_1606[c] -> s_0423[c] + s_0633[c] + s_0794[c] + s_1379[c] YHR020W 0.00 1000.00 0.00 +r_0941 s_0434[c] + s_1035[c] + s_1606[c] -> s_0423[c] + s_0633[c] + s_1379[c] YHR020W 0.00 1000.00 0.00 r_0942 3 s_1278[m] + 2 s_1385[m] -> 6 s_0807[m] + 2 s_1383[m] YER014W 0.00 1000.00 0.00 r_0943 s_1218[c] + s_1322[c] -> s_0415[c] + s_0794[c] + s_1216[c] ( YDR400W and YLR017W and YLR209C ) 0.00 1000.00 0.00 r_0949 s_0790[c] + s_1322[c] <=> s_0415[c] + s_0787[c] YLR209C -1000.00 1000.00 0.00 @@ -736,19 +736,19 @@ r_0962 s_0394[c] + s_0794[c] + s_1360[c] -> s_0434[c] + s_1399[c] ( YAL038W or r_0963 s_0156[m] + s_0799[m] + s_1205[m] + s_1278[m] -> s_0154[m] + s_0807[m] + s_1200[m] ( YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C ) 0.00 1000.00 0.00 r_0965 s_0434[c] + s_1405[c] -> s_0394[c] + s_0714[c] + s_0794[c] YDR236C 0.00 1000.00 0.00 r_0966 s_0437[m] + s_1407[m] -> s_0397[m] + s_0716[m] + s_0799[m] YDR236C 0.00 1000.00 0.00 -r_0967 s_0158[c] + s_0314[c] -> s_0328[c] + 2 s_0803[c] + s_1322[c] YOL143C 0.00 1000.00 0.00 -r_0968 2 s_0328[c] -> s_0314[c] + s_1405[c] YBR256C 0.00 1000.00 0.00 +r_0967 s_0158[c] + s_0314[c] -> s_0328[c] + s_0794[c] + 2 s_0803[c] + s_1322[c] YOL143C 0.00 1000.00 0.00 +r_0968 2 s_0328[c] + s_0794[c] -> s_0314[c] + s_1405[c] YBR256C 0.00 1000.00 0.00 r_0969 s_0434[c] + s_0575[c] -> s_0394[c] + s_0794[c] + s_1408[c] YCR036W 0.00 1000.00 0.00 -r_0970 s_0434[c] + s_1616[c] -> s_0586[c] + s_0803[c] + s_1620[c] YGR209C 0.00 1000.00 0.00 -r_0971 s_0539[c] + s_1616[c] -> s_0590[c] + s_0803[c] + s_1620[c] YGR209C 0.00 1000.00 0.00 -r_0972 s_0785[c] + s_1616[c] -> s_0617[c] + s_0803[c] + s_1620[c] YGR209C 0.00 1000.00 0.00 -r_0973 s_1559[c] + s_1616[c] -> s_0656[c] + s_0803[c] + s_1620[c] YGR209C 0.00 1000.00 0.00 -r_0974 s_0394[c] + s_1616[c] -> s_0582[c] + s_0803[c] + s_1620[c] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 -r_0975 s_0398[n] + s_1618[n] -> s_0583[n] + s_0808[n] + s_1622[n] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 -r_0976 s_0467[c] + s_1616[c] -> s_0587[c] + s_0803[c] + s_1620[c] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 -r_0977 s_0468[n] + s_1618[n] -> s_0588[n] + s_0808[n] + s_1622[n] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 -r_0978 s_0739[c] + s_1616[c] -> s_0613[c] + s_0803[c] + s_1620[c] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 -r_0979 s_0742[n] + s_1618[n] -> s_0614[n] + s_0808[n] + s_1622[n] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 +r_0970 s_0434[c] + s_0794[c] + s_1616[c] -> s_0586[c] + s_0803[c] + s_1620[c] YGR209C 0.00 1000.00 0.00 +r_0971 s_0539[c] + s_0794[c] + s_1616[c] -> s_0590[c] + s_0803[c] + s_1620[c] YGR209C 0.00 1000.00 0.00 +r_0972 s_0785[c] + s_0794[c] + s_1616[c] -> s_0617[c] + s_0803[c] + s_1620[c] YGR209C 0.00 1000.00 0.00 +r_0973 s_0794[c] + s_1559[c] + s_1616[c] -> s_0656[c] + s_0803[c] + s_1620[c] YGR209C 0.00 1000.00 0.00 +r_0974 s_0394[c] + s_0794[c] + s_1616[c] -> s_0582[c] + s_0803[c] + s_1620[c] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 +r_0975 s_0398[n] + s_0800[n] + s_1618[n] -> s_0583[n] + s_0808[n] + s_1622[n] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 +r_0976 s_0467[c] + s_0794[c] + s_1616[c] -> s_0587[c] + s_0803[c] + s_1620[c] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 +r_0977 s_0468[n] + s_0800[n] + s_1618[n] -> s_0588[n] + s_0808[n] + s_1622[n] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 +r_0978 s_0739[c] + s_0794[c] + s_1616[c] -> s_0613[c] + s_0803[c] + s_1620[c] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 +r_0979 s_0742[n] + s_0800[n] + s_1618[n] -> s_0614[n] + s_0808[n] + s_1622[n] ( YER070W or YGR180C or YIL066C or YJL026W ) 0.00 1000.00 0.00 r_0982 s_0577[c] <=> s_1408[c] YOR095C -1000.00 1000.00 0.00 r_0983 s_0434[c] + s_1218[c] -> s_0394[c] + s_0794[c] + s_1224[c] YNL129W 0.00 1000.00 0.00 r_0984 s_0577[c] <=> s_0581[c] YJL121C -1000.00 1000.00 0.00 @@ -759,13 +759,13 @@ r_0988 s_0803[c] + s_1038[c] + s_1198[c] -> s_0180[c] + s_0794[c] + s_1025[c] + r_0989 s_0794[c] + s_0959[c] + s_0991[c] + s_1212[c] -> s_0803[c] + s_1038[c] + s_1207[c] YNR050C 0.00 1000.00 0.00 r_0990 s_1426[c] <=> s_0551[c] + s_0629[c] YKL060C -1000.00 1000.00 0.00 r_0992 s_0373[c] + s_1039[c] -> s_0529[c] + s_1234[c] (( YDL040C and YGR147C and YHR013C ) or ( YDL040C and YGR147C )) 0.00 1000.00 0.00 -r_0993 s_1040[er] + s_1303[er] -> s_0231[er] + s_0457[er] + s_0530[er] (( YBR058C-A and YDR062W and YMR296C ) or ( YDR062W and YMR296C )) 0.00 1000.00 0.00 +r_0993 s_0795[er] + s_1040[er] + s_1303[er] -> s_0231[er] + s_0457[er] + s_0530[er] (( YBR058C-A and YDR062W and YMR296C ) or ( YDR062W and YMR296C )) 0.00 1000.00 0.00 r_0995 s_0434[c] + s_1039[c] + s_1607[c] -> s_0423[c] + s_0633[c] + s_1428[c] ( YDR023W or YHR011W ) 0.00 1000.00 0.00 r_0996 s_0211[c] + s_0794[c] + s_1212[c] -> s_1207[c] + s_1429[c] YDR127W 0.00 1000.00 0.00 r_0997 s_0434[c] + s_1429[c] -> s_0261[c] + s_0394[c] + s_0794[c] YDR127W 0.00 1000.00 0.00 -r_0998 s_1198[c] + s_1375[c] -> s_0794[c] + s_1203[c] + s_1431[c] YBR213W 0.00 1000.00 0.00 -r_0999 s_0924[c] + s_1431[c] -> 3 s_0794[c] + s_1430[c] YBR213W 0.00 1000.00 0.00 -r_1000 s_0717[c] + s_0725[c] <=> s_0714[c] + s_1458[c] YEL047C -1000.00 1000.00 0.00 +r_0998 s_1198[c] + s_1375[c] -> 2 s_0794[c] + s_1203[c] + s_1431[c] YBR213W 0.00 1000.00 0.00 +r_0999 s_0924[c] + s_1431[c] -> 2 s_0794[c] + s_1430[c] YBR213W 0.00 1000.00 0.00 +r_1000 s_0717[c] + s_0725[c] <=> s_0714[c] + s_0794[c] + s_1458[c] YEL047C -1000.00 1000.00 0.00 r_1001 s_1389[c] + s_1420[c] -> s_0303[c] + s_0794[c] + s_1439[c] YPR069C 0.00 1000.00 0.00 r_1002 s_1420[c] + s_1439[c] -> s_0303[c] + s_0794[c] + s_1442[c] YLR146C 0.00 1000.00 0.00 r_1003 s_1446[er] -> s_0825[er] + s_1240[er] YDR294C 0.00 1000.00 0.00 @@ -784,7 +784,7 @@ r_1023 s_0803[c] + s_1207[c] + s_1461[c] -> 2 s_0794[c] + s_1212[c] + s_1458[c] r_1024 s_0805[e] + s_1466[e] -> s_0554[e] + s_0565[e] YIL162W 0.00 1000.00 0.00 r_1025 s_0434[c] + s_0794[c] + s_1467[c] -> s_0298[c] + s_0633[c] YJR010W 0.00 1000.00 0.00 r_1026 s_0394[c] + s_0794[c] + s_1467[c] -> s_0298[c] + s_1322[c] YCL050C 0.00 1000.00 0.00 -r_1027 5 s_0794[c] + 3 s_1212[c] + s_1469[c] -> 3 s_0803[c] + s_0841[c] + 3 s_1207[c] ( YFR030W and YJR137C ) 0.00 1000.00 0.00 +r_1027 4 s_0794[c] + 3 s_1212[c] + s_1469[c] -> 3 s_0803[c] + s_0841[c] + 3 s_1207[c] ( YFR030W and YJR137C ) 0.00 1000.00 0.00 r_1029 s_0180[c] + s_1275[c] + s_1471[c] -> s_0417[c] + s_0456[c] + s_0794[c] + s_1458[c] + s_1469[c] YLL057C 0.00 1000.00 0.00 r_1030 s_0305[m] + s_0807[m] -> s_0321[m] + s_0799[m] ( YAL044C and YDR019C and YFL018C and YMR189W ) 0.00 1000.00 0.00 r_1031 s_0434[c] + s_0991[c] + s_1487[c] <=> s_0308[c] + s_0394[c] + s_0794[c] + s_1322[c] ( YKL132C or YOR241W ) -1000.00 1000.00 0.00 @@ -793,9 +793,9 @@ r_1033 s_0805[e] + s_1498[e] -> s_1324[e] + s_1490[e] YBR092C 0.00 1000.00 r_1034 s_0434[c] + s_1489[c] -> s_0423[c] + s_0794[c] + s_1475[c] YOR143C 0.00 1000.00 0.00 r_1035 s_0434[c] + s_1475[c] -> s_0394[c] + s_1532[c] YOR143C 0.00 1000.00 0.00 r_1036 s_0267[c] + s_0293[c] + s_0794[c] -> s_0633[c] + s_1497[c] YPL214C 0.00 1000.00 0.00 -r_1037 s_0839[n] + s_1618[n] -> 2 s_0808[n] + s_1622[n] (( YGR209C and YIL010W ) or ( YIL010W and YLR043C )) 0.00 1000.00 0.00 -r_1038 s_0794[c] + s_1212[c] + s_1620[c] -> s_1207[c] + s_1616[c] (( YDR353W and YGR209C ) or ( YDR353W and YLR043C ) or YDR353W ) 0.00 1000.00 0.00 -r_1039 s_0799[m] + s_1214[m] + s_1621[m] -> s_1210[m] + s_1617[m] (( YCR083W and YHR106W ) or ( YCR083W and YPL091W )) 0.00 1000.00 0.00 +r_1037 s_0800[n] + s_0839[n] + s_1618[n] -> 2 s_0808[n] + s_1622[n] (( YGR209C and YIL010W ) or ( YIL010W and YLR043C )) 0.00 1000.00 0.00 +r_1038 s_1212[c] + s_1620[c] -> s_1207[c] + s_1616[c] (( YDR353W and YGR209C ) or ( YDR353W and YLR043C ) or YDR353W ) 0.00 1000.00 0.00 +r_1039 s_1214[m] + s_1621[m] -> s_1210[m] + s_1617[m] (( YCR083W and YHR106W ) or ( YCR083W and YPL091W )) 0.00 1000.00 0.00 r_1040 s_1045[c] -> s_0359[c] + s_1003[c] YEL046C 0.00 1000.00 0.00 r_1041 s_0803[c] + s_1238[c] -> s_1045[c] + s_1322[c] YCR053W 0.00 1000.00 0.00 r_1042 s_0434[c] + s_1045[c] + s_1608[c] -> s_0423[c] + s_0633[c] + s_1491[c] YIL078W 0.00 1000.00 0.00 @@ -845,15 +845,15 @@ r_1095 s_1408[c] + s_1550[c] <=> s_0803[c] + s_1388[c] ( YFL001W or YGL063W or r_1619 s_0782[c] + s_0803[c] -> s_0790[c] + s_1322[c] YER037W 0.00 1000.00 0.00 r_1838 s_0182[m] + s_0376[m] + s_0807[m] -> s_0532[m] + s_0799[m] + s_0834[m] ( YDL131W or YDL182W ) 0.00 1000.00 0.00 r_2029 s_0434[c] + s_1396[c] -> s_0394[c] + s_0794[c] + s_1398[c] YEL029C 0.00 1000.00 0.00 -r_2112 s_1020[c] + s_1399[c] <=> s_0955[c] + s_2763[c] YJL060W -1000.00 1000.00 0.00 -r_2113 s_2763[c] -> s_2764[c] 0.00 1000.00 0.00 -r_2114 s_0147[c] -> s_0803[c] + s_1403[c] 0.00 1000.00 0.00 +r_2112 s_1020[c] + s_1399[c] <=> s_0803[c] + s_0955[c] + s_2763[c] YJL060W -1000.00 1000.00 0.00 +r_2113 2 s_0794[c] + s_1212[c] + s_2763[c] -> s_0803[c] + s_1207[c] + s_2764[c] 0.00 1000.00 0.00 +r_2114 s_0147[c] -> s_0794[c] + s_0803[c] + s_1403[c] 0.00 1000.00 0.00 r_2115 s_0359[c] + s_0794[c] + s_1203[c] -> s_0680[c] + s_1198[c] ( YBR145W or YOL086C ) 0.00 1000.00 0.00 -r_2116 s_0359[c] + s_0803[c] + s_1198[c] -> s_0362[c] + s_0794[c] + s_1203[c] ( YMR110C or YMR170C or YER073W or YOR374W ) 0.00 1000.00 0.00 +r_2116 s_0359[c] + s_0803[c] + s_1198[c] -> s_0362[c] + 2 s_0794[c] + s_1203[c] ( YMR110C or YMR170C or YER073W or YOR374W ) 0.00 1000.00 0.00 r_2117 s_1032[c] + s_1399[c] <=> s_0951[c] + s_0955[c] YHR137W -1000.00 1000.00 0.00 r_2118 s_0951[c] + s_1048[c] -> s_0855[c] + s_1032[c] YHR137W 0.00 1000.00 0.00 r_2119 s_0204[c] + s_0955[c] <=> s_1051[c] + s_1399[c] YHR137W -1000.00 1000.00 0.00 -r_2126 s_1426[c] -> s_1322[c] + s_1427[c] YKR043C 0.00 1000.00 0.00 +r_2126 s_0803[c] + s_1426[c] -> s_1322[c] + s_1427[c] YKR043C 0.00 1000.00 0.00 r_2131 s_0941[m] + s_1210[m] -> s_0182[m] + s_0460[m] + s_1214[m] YDL066W 0.00 1000.00 0.00 r_2140 s_0373[c] + 21 s_0794[c] + 7 s_1101[c] + 14 s_1212[c] -> 7 s_0456[c] + 7 s_0529[c] + 7 s_0803[c] + 14 s_1207[c] + s_1302[c] ( YKL182W and YPL231W ) 0.00 1000.00 0.00 r_2141 s_0373[c] + 24 s_0794[c] + 8 s_1101[c] + 16 s_1212[c] -> 8 s_0456[c] + 8 s_0529[c] + 8 s_0803[c] + 16 s_1207[c] + s_1454[c] ( YKL182W and YPL231W ) 0.00 1000.00 0.00 @@ -924,8 +924,8 @@ r_2215 s_2785[erm] + s_2831[erm] + s_2870[erm] <=> s_2816[erm] + s_2833[erm] + r_2216 s_0531[lp] + s_2840[lp] + s_2871[lp] <=> s_0635[lp] + s_2842[lp] + s_2872[lp] YBR041W -1000.00 1000.00 0.00 r_2217 s_0531[lp] + s_2840[lp] + s_2873[lp] <=> s_0635[lp] + s_2842[lp] + s_2874[lp] YBR041W -1000.00 1000.00 0.00 r_2218 s_0531[lp] + s_2840[lp] + s_2875[lp] <=> s_0635[lp] + s_2842[lp] + s_2876[lp] YBR041W -1000.00 1000.00 0.00 -r_2232 s_0809[p] + s_2884[p] -> s_0534[p] + s_0801[p] + s_2882[p] YJR019C 0.00 1000.00 0.00 -r_2233 s_0809[p] + s_2885[p] -> s_0534[p] + s_0801[p] + s_2883[p] YJR019C 0.00 1000.00 0.00 +r_2232 s_0809[p] + s_2884[p] -> s_0534[p] + 5 s_0801[p] + s_2882[p] YJR019C 0.00 1000.00 0.00 +r_2233 s_0809[p] + s_2885[p] -> s_0534[p] + 5 s_0801[p] + s_2883[p] YJR019C 0.00 1000.00 0.00 r_2234 s_0809[p] + s_2854[p] -> s_0534[p] + s_0801[p] + s_1298[p] YJR019C 0.00 1000.00 0.00 r_2235 s_0809[p] + s_1265[p] -> s_0534[p] + s_0801[p] + s_2855[p] YJR019C 0.00 1000.00 0.00 r_2236 s_1279[p] + s_2884[p] -> s_0840[p] + s_2886[p] YGL205W 0.00 1000.00 0.00 @@ -934,7 +934,7 @@ r_2238 s_1258[p] + s_1279[p] -> s_0840[p] + s_2888[p] YGL205W 0.00 1000.00 r_2239 s_1279[p] + s_2879[p] -> s_0840[p] + s_2889[p] YGL205W 0.00 1000.00 0.00 r_2240 s_1279[p] + s_2881[p] -> s_0840[p] + s_2890[p] YGL205W 0.00 1000.00 0.00 r_2241 s_1279[p] + s_1482[p] -> s_0840[p] + s_2891[p] YGL205W 0.00 1000.00 0.00 -r_2242 s_1279[p] + s_2854[p] -> s_0840[p] + s_2892[p] YGL205W 0.00 1000.00 0.00 +r_2242 4 s_0801[p] + s_1279[p] + s_2854[p] -> s_0840[p] + s_2892[p] YGL205W 0.00 1000.00 0.00 r_2243 s_1279[p] + s_2893[p] -> s_0840[p] + s_2894[p] YGL205W 0.00 1000.00 0.00 r_2244 s_1279[p] + s_2895[p] -> s_0840[p] + s_2896[p] YGL205W 0.00 1000.00 0.00 r_2245 s_1265[p] + s_1279[p] -> s_0840[p] + s_2897[p] YGL205W 0.00 1000.00 0.00 @@ -946,16 +946,16 @@ r_2250 s_0809[p] + s_1519[p] -> s_0054[p] YKR009C 0.00 1000.00 0.00 r_2251 s_0809[p] + s_0823[p] -> s_0051[p] YKR009C 0.00 1000.00 0.00 r_2252 s_0809[p] + s_1516[p] -> s_0229[p] YKR009C 0.00 1000.00 0.00 r_2253 s_0809[p] + s_1513[p] -> s_0045[p] YKR009C 0.00 1000.00 0.00 -r_2254 s_0809[p] + s_2886[p] -> s_2902[p] YKR009C 0.00 1000.00 0.00 +r_2254 s_0809[p] + s_2886[p] -> 4 s_0801[p] + s_2902[p] YKR009C 0.00 1000.00 0.00 r_2255 s_0809[p] + s_2887[p] -> s_2903[p] YKR009C 0.00 1000.00 0.00 -r_2256 s_0809[p] + s_2888[p] -> s_2904[p] YKR009C 0.00 1000.00 0.00 +r_2256 4 s_0801[p] + s_0809[p] + s_2888[p] -> s_2904[p] YKR009C 0.00 1000.00 0.00 r_2257 s_0809[p] + s_2889[p] -> s_2905[p] YKR009C 0.00 1000.00 0.00 r_2258 s_0809[p] + s_2890[p] -> s_2906[p] YKR009C 0.00 1000.00 0.00 r_2259 s_0809[p] + s_2891[p] -> s_2907[p] YKR009C 0.00 1000.00 0.00 r_2260 s_0809[p] + s_2892[p] -> s_2908[p] YKR009C 0.00 1000.00 0.00 r_2261 s_0809[p] + s_2894[p] -> s_2909[p] YKR009C 0.00 1000.00 0.00 r_2262 s_0809[p] + s_2896[p] -> s_2910[p] YKR009C 0.00 1000.00 0.00 -r_2263 s_0809[p] + s_2897[p] -> s_2911[p] YKR009C 0.00 1000.00 0.00 +r_2263 4 s_0801[p] + s_0809[p] + s_2897[p] -> s_2911[p] YKR009C 0.00 1000.00 0.00 r_2264 s_0809[p] + s_2899[p] -> s_2912[p] YKR009C 0.00 1000.00 0.00 r_2265 s_0809[p] + s_2901[p] -> s_2913[p] YKR009C 0.00 1000.00 0.00 r_2266 s_0042[p] + s_1202[p] -> s_0239[p] + s_0801[p] + s_1206[p] YKR009C 0.00 1000.00 0.00 @@ -987,33 +987,33 @@ r_2291 s_0534[p] + s_2922[p] -> s_0378[p] + s_2926[p] YIL160C 0.00 1000.00 r_2292 s_0534[p] + s_2923[p] -> s_0378[p] + s_2898[p] YIL160C 0.00 1000.00 0.00 r_2293 s_0534[p] + s_2924[p] -> s_0378[p] + s_2900[p] YIL160C 0.00 1000.00 0.00 r_2294 s_0534[p] + s_2925[p] -> s_0378[p] + s_2927[p] YIL160C 0.00 1000.00 0.00 -r_2295 s_2926[p] -> s_1507[p] YLR284C 0.00 1000.00 0.00 +r_2295 s_2926[p] -> 4 s_0801[p] + s_1507[p] YLR284C 0.00 1000.00 0.00 r_2296 s_2896[p] -> s_2928[p] YLR284C 0.00 1000.00 0.00 -r_2297 s_2929[p] -> s_1510[p] YLR284C 0.00 1000.00 0.00 -r_2298 s_2927[p] -> s_1510[p] YLR284C 0.00 1000.00 0.00 +r_2297 s_2929[p] -> 4 s_0801[p] + s_1510[p] YLR284C 0.00 1000.00 0.00 +r_2298 s_2927[p] -> 4 s_0801[p] + s_1510[p] YLR284C 0.00 1000.00 0.00 r_2299 s_2901[p] -> s_2930[p] YLR284C 0.00 1000.00 0.00 -r_2300 s_2931[p] -> s_1519[p] YLR284C 0.00 1000.00 0.00 +r_2300 s_2931[p] -> 4 s_0801[p] + s_1519[p] YLR284C 0.00 1000.00 0.00 r_2301 s_2928[p] -> s_2932[p] YOR180C 0.00 1000.00 0.00 r_2302 s_2930[p] -> s_2933[p] YOR180C 0.00 1000.00 0.00 r_2303 s_0801[p] + s_1215[p] + s_2932[p] -> s_1211[p] + s_2929[p] YNL202W 0.00 1000.00 0.00 r_2304 s_0801[p] + s_1215[p] + s_2933[p] -> s_1211[p] + s_2931[p] YNL202W 0.00 1000.00 0.00 r_2305 s_0516[c] + s_0803[c] <=> s_0940[c] YLR304C -1000.00 1000.00 0.00 -r_2308 s_2789[erm] + s_2934[erm] -> s_2785[erm] + s_2935[erm] ( YBL011W or YKR067W ) 0.00 1000.00 0.00 -r_2309 s_2819[erm] + s_2934[erm] -> s_2785[erm] + s_2936[erm] ( YBL011W or YKR067W ) 0.00 1000.00 0.00 -r_2310 s_2791[erm] + s_2934[erm] -> s_2785[erm] + s_2937[erm] YKR067W 0.00 1000.00 0.00 -r_2311 s_2821[erm] + s_2934[erm] -> s_2785[erm] + s_2938[erm] YKR067W 0.00 1000.00 0.00 -r_2312 s_2789[erm] + s_2939[erm] -> s_2785[erm] + s_2940[erm] ( YBL011W or YKR067W ) 0.00 1000.00 0.00 -r_2313 s_2819[erm] + s_2939[erm] -> s_2785[erm] + s_2941[erm] ( YBL011W or YKR067W ) 0.00 1000.00 0.00 -r_2314 s_2791[erm] + s_2939[erm] -> s_2785[erm] + s_2942[erm] YKR067W 0.00 1000.00 0.00 -r_2315 s_2821[erm] + s_2939[erm] -> s_2785[erm] + s_2943[erm] YKR067W 0.00 1000.00 0.00 -r_2316 s_0769[lp] + s_2847[lp] -> s_0531[lp] + s_2944[lp] YKR067W 0.00 1000.00 0.00 -r_2317 s_0769[lp] + s_2849[lp] -> s_0531[lp] + s_2945[lp] YKR067W 0.00 1000.00 0.00 -r_2318 s_0769[lp] + s_2851[lp] -> s_0531[lp] + s_2946[lp] YKR067W 0.00 1000.00 0.00 -r_2319 s_0769[lp] + s_2853[lp] -> s_0531[lp] + s_2947[lp] YKR067W 0.00 1000.00 0.00 -r_2320 s_0631[lp] + s_2847[lp] -> s_0531[lp] + s_2948[lp] YKR067W 0.00 1000.00 0.00 -r_2321 s_0631[lp] + s_2849[lp] -> s_0531[lp] + s_2949[lp] YKR067W 0.00 1000.00 0.00 -r_2322 s_0631[lp] + s_2851[lp] -> s_0531[lp] + s_2950[lp] YKR067W 0.00 1000.00 0.00 -r_2323 s_0631[lp] + s_2853[lp] -> s_0531[lp] + s_2951[lp] YKR067W 0.00 1000.00 0.00 +r_2308 2 s_2783[erm] + s_2789[erm] + s_2934[erm] -> s_2785[erm] + s_2935[erm] ( YBL011W or YKR067W ) 0.00 1000.00 0.00 +r_2309 2 s_2783[erm] + s_2819[erm] + s_2934[erm] -> s_2785[erm] + s_2936[erm] ( YBL011W or YKR067W ) 0.00 1000.00 0.00 +r_2310 2 s_2783[erm] + s_2791[erm] + s_2934[erm] -> s_2785[erm] + s_2937[erm] YKR067W 0.00 1000.00 0.00 +r_2311 2 s_2783[erm] + s_2821[erm] + s_2934[erm] -> s_2785[erm] + s_2938[erm] YKR067W 0.00 1000.00 0.00 +r_2312 2 s_2783[erm] + s_2789[erm] + s_2939[erm] -> s_2785[erm] + s_2940[erm] ( YBL011W or YKR067W ) 0.00 1000.00 0.00 +r_2313 2 s_2783[erm] + s_2819[erm] + s_2939[erm] -> s_2785[erm] + s_2941[erm] ( YBL011W or YKR067W ) 0.00 1000.00 0.00 +r_2314 2 s_2783[erm] + s_2791[erm] + s_2939[erm] -> s_2785[erm] + s_2942[erm] YKR067W 0.00 1000.00 0.00 +r_2315 2 s_2783[erm] + s_2821[erm] + s_2939[erm] -> s_2785[erm] + s_2943[erm] YKR067W 0.00 1000.00 0.00 +r_2316 s_0769[lp] + 2 s_2783[erm] + s_2847[lp] -> s_0531[lp] + s_2944[lp] YKR067W 0.00 1000.00 0.00 +r_2317 s_0769[lp] + 2 s_2783[erm] + s_2849[lp] -> s_0531[lp] + s_2945[lp] YKR067W 0.00 1000.00 0.00 +r_2318 s_0769[lp] + 2 s_2783[erm] + s_2851[lp] -> s_0531[lp] + s_2946[lp] YKR067W 0.00 1000.00 0.00 +r_2319 s_0769[lp] + 2 s_2783[erm] + s_2853[lp] -> s_0531[lp] + s_2947[lp] YKR067W 0.00 1000.00 0.00 +r_2320 s_0631[lp] + 2 s_0798[lp] + s_2847[lp] -> s_0531[lp] + s_2948[lp] YKR067W 0.00 1000.00 0.00 +r_2321 s_0631[lp] + 2 s_0798[lp] + s_2849[lp] -> s_0531[lp] + s_2949[lp] YKR067W 0.00 1000.00 0.00 +r_2322 s_0631[lp] + 2 s_0798[lp] + s_2851[lp] -> s_0531[lp] + s_2950[lp] YKR067W 0.00 1000.00 0.00 +r_2323 s_0631[lp] + 2 s_0798[lp] + s_2853[lp] -> s_0531[lp] + s_2951[lp] YKR067W 0.00 1000.00 0.00 r_2324 s_2783[erm] + s_2799[erm] + s_2940[erm] -> s_2800[erm] + s_2935[erm] YIL124W 0.00 1000.00 0.00 r_2325 s_2783[erm] + s_2799[erm] + s_2941[erm] -> s_2800[erm] + s_2936[erm] YIL124W 0.00 1000.00 0.00 r_2326 s_2783[erm] + s_2799[erm] + s_2942[erm] -> s_2800[erm] + s_2937[erm] YIL124W 0.00 1000.00 0.00 @@ -1034,30 +1034,30 @@ r_2340 s_2853[lp] + s_2944[lp] -> s_0531[lp] + s_2962[lp] ( YDL052C or YKR089C r_2341 s_2853[lp] + s_2945[lp] -> s_0531[lp] + s_2963[lp] ( YDL052C or YKR089C or YOR081C ) 0.00 1000.00 0.00 r_2342 s_2853[lp] + s_2946[lp] -> s_0531[lp] + s_2964[lp] ( YDL052C or YKR089C or YOR081C ) 0.00 1000.00 0.00 r_2343 s_2853[lp] + s_2947[lp] -> s_0531[lp] + s_2965[lp] ( YDL052C or YKR089C or YOR081C ) 0.00 1000.00 0.00 -r_2344 s_2808[erm] + s_2954[erm] -> s_2966[erm] + s_2967[erm] YMR165C 0.00 1000.00 0.00 -r_2345 s_2808[erm] + s_2955[erm] -> s_2966[erm] + s_2968[erm] YMR165C 0.00 1000.00 0.00 -r_2346 s_2808[erm] + s_2956[erm] -> s_2966[erm] + s_2969[erm] YMR165C 0.00 1000.00 0.00 -r_2347 s_2808[erm] + s_2957[erm] -> s_2966[erm] + s_2970[erm] YMR165C 0.00 1000.00 0.00 -r_2348 s_2808[erm] + s_2958[erm] -> s_2966[erm] + s_2971[erm] YMR165C 0.00 1000.00 0.00 -r_2349 s_2808[erm] + s_2959[erm] -> s_2966[erm] + s_2972[erm] YMR165C 0.00 1000.00 0.00 -r_2350 s_2808[erm] + s_2960[erm] -> s_2966[erm] + s_2973[erm] YMR165C 0.00 1000.00 0.00 -r_2351 s_2808[erm] + s_2961[erm] -> s_2966[erm] + s_2974[erm] YMR165C 0.00 1000.00 0.00 -r_2352 s_2975[vm] + s_2976[vm] -> s_2977[vm] + s_2978[vm] YDR284C 0.00 1000.00 0.00 -r_2353 s_2976[vm] + s_2979[vm] -> s_2977[vm] + s_2980[vm] YDR284C 0.00 1000.00 0.00 -r_2354 s_2976[vm] + s_2981[vm] -> s_2977[vm] + s_2982[vm] YDR284C 0.00 1000.00 0.00 -r_2355 s_2976[vm] + s_2983[vm] -> s_2977[vm] + s_2984[vm] YDR284C 0.00 1000.00 0.00 -r_2356 s_2976[vm] + s_2985[vm] -> s_2977[vm] + s_2986[vm] YDR284C 0.00 1000.00 0.00 -r_2357 s_2976[vm] + s_2987[vm] -> s_2977[vm] + s_2988[vm] YDR284C 0.00 1000.00 0.00 -r_2358 s_2976[vm] + s_2989[vm] -> s_2977[vm] + s_2990[vm] YDR284C 0.00 1000.00 0.00 -r_2359 s_2976[vm] + s_2991[vm] -> s_2977[vm] + s_2992[vm] YDR284C 0.00 1000.00 0.00 -r_2360 s_2993[gm] + s_2994[gm] -> s_2995[gm] + s_2996[gm] YDR503C 0.00 1000.00 0.00 -r_2361 s_2994[gm] + s_2997[gm] -> s_2995[gm] + s_2998[gm] YDR503C 0.00 1000.00 0.00 -r_2362 s_2994[gm] + s_2999[gm] -> s_2995[gm] + s_3000[gm] YDR503C 0.00 1000.00 0.00 -r_2363 s_2994[gm] + s_3001[gm] -> s_2995[gm] + s_3002[gm] YDR503C 0.00 1000.00 0.00 -r_2364 s_2994[gm] + s_3003[gm] -> s_2995[gm] + s_3004[gm] YDR503C 0.00 1000.00 0.00 -r_2365 s_2994[gm] + s_3005[gm] -> s_2995[gm] + s_3006[gm] YDR503C 0.00 1000.00 0.00 -r_2366 s_2994[gm] + s_3007[gm] -> s_2995[gm] + s_3008[gm] YDR503C 0.00 1000.00 0.00 -r_2367 s_2994[gm] + s_3009[gm] -> s_2995[gm] + s_3010[gm] YDR503C 0.00 1000.00 0.00 +r_2344 s_2808[erm] + s_2954[erm] -> 2 s_2783[erm] + s_2966[erm] + s_2967[erm] YMR165C 0.00 1000.00 0.00 +r_2345 s_2808[erm] + s_2955[erm] -> 2 s_2783[erm] + s_2966[erm] + s_2968[erm] YMR165C 0.00 1000.00 0.00 +r_2346 s_2808[erm] + s_2956[erm] -> 2 s_2783[erm] + s_2966[erm] + s_2969[erm] YMR165C 0.00 1000.00 0.00 +r_2347 s_2808[erm] + s_2957[erm] -> 2 s_2783[erm] + s_2966[erm] + s_2970[erm] YMR165C 0.00 1000.00 0.00 +r_2348 s_2808[erm] + s_2958[erm] -> 2 s_2783[erm] + s_2966[erm] + s_2971[erm] YMR165C 0.00 1000.00 0.00 +r_2349 s_2808[erm] + s_2959[erm] -> 2 s_2783[erm] + s_2966[erm] + s_2972[erm] YMR165C 0.00 1000.00 0.00 +r_2350 s_2808[erm] + s_2960[erm] -> 2 s_2783[erm] + s_2966[erm] + s_2973[erm] YMR165C 0.00 1000.00 0.00 +r_2351 s_2808[erm] + s_2961[erm] -> 2 s_2783[erm] + s_2966[erm] + s_2974[erm] YMR165C 0.00 1000.00 0.00 +r_2352 s_2975[vm] + s_2976[vm] -> s_2977[vm] + s_2978[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_2353 s_2976[vm] + s_2979[vm] -> s_2977[vm] + s_2980[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_2354 s_2976[vm] + s_2981[vm] -> s_2977[vm] + s_2982[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_2355 s_2976[vm] + s_2983[vm] -> s_2977[vm] + s_2984[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_2356 s_2976[vm] + s_2985[vm] -> s_2977[vm] + s_2986[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_2357 s_2976[vm] + s_2987[vm] -> s_2977[vm] + s_2988[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_2358 s_2976[vm] + s_2989[vm] -> s_2977[vm] + s_2990[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_2359 s_2976[vm] + s_2991[vm] -> s_2977[vm] + s_2992[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_2360 s_2993[gm] + s_2994[gm] -> s_2995[gm] + s_2996[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_2361 s_2994[gm] + s_2997[gm] -> s_2995[gm] + s_2998[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_2362 s_2994[gm] + s_2999[gm] -> s_2995[gm] + s_3000[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_2363 s_2994[gm] + s_3001[gm] -> s_2995[gm] + s_3002[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_2364 s_2994[gm] + s_3003[gm] -> s_2995[gm] + s_3004[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_2365 s_2994[gm] + s_3005[gm] -> s_2995[gm] + s_3006[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_2366 s_2994[gm] + s_3007[gm] -> s_2995[gm] + s_3008[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_2367 s_2994[gm] + s_3009[gm] -> s_2995[gm] + s_3010[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 r_2368 s_2789[erm] + s_2967[erm] -> s_2785[erm] + s_3011[erm] ( YCR048W or YNR019W or YOR245C ) 0.00 1000.00 0.00 r_2369 s_2789[erm] + s_2968[erm] -> s_2785[erm] + s_3012[erm] ( YCR048W or YNR019W or YOR245C ) 0.00 1000.00 0.00 r_2370 s_2789[erm] + s_2969[erm] -> s_2785[erm] + s_3013[erm] ( YCR048W or YNR019W or YOR245C ) 0.00 1000.00 0.00 @@ -1136,48 +1136,48 @@ r_2442 s_3093[mm] + s_3094[mm] + s_3099[mm] <=> s_3095[mm] + s_3100[mm] YBR029 r_2443 s_3093[mm] + s_3094[mm] + s_3101[mm] <=> s_3095[mm] + s_3102[mm] YBR029C -1000.00 1000.00 0.00 r_2444 s_3093[mm] + s_3094[mm] + s_3103[mm] <=> s_3095[mm] + s_3104[mm] YBR029C -1000.00 1000.00 0.00 r_2445 s_3093[mm] + s_3094[mm] + s_3105[mm] <=> s_3095[mm] + s_3106[mm] YBR029C -1000.00 1000.00 0.00 -r_2446 s_3084[erm] + s_3107[erm] -> s_2783[erm] + s_3108[erm] + s_3109[erm] YER026C 0.00 1000.00 0.00 -r_2447 s_3085[erm] + s_3107[erm] -> s_2783[erm] + s_3108[erm] + s_3110[erm] YER026C 0.00 1000.00 0.00 -r_2448 s_3086[erm] + s_3107[erm] -> s_2783[erm] + s_3108[erm] + s_3111[erm] YER026C 0.00 1000.00 0.00 -r_2449 s_3087[erm] + s_3107[erm] -> s_2783[erm] + s_3108[erm] + s_3112[erm] YER026C 0.00 1000.00 0.00 -r_2450 s_3088[erm] + s_3107[erm] -> s_2783[erm] + s_3108[erm] + s_3113[erm] YER026C 0.00 1000.00 0.00 -r_2451 s_3089[erm] + s_3107[erm] -> s_2783[erm] + s_3108[erm] + s_3114[erm] YER026C 0.00 1000.00 0.00 -r_2452 s_3090[erm] + s_3107[erm] -> s_2783[erm] + s_3108[erm] + s_3115[erm] YER026C 0.00 1000.00 0.00 -r_2453 s_3091[erm] + s_3107[erm] -> s_2783[erm] + s_3108[erm] + s_3116[erm] YER026C 0.00 1000.00 0.00 -r_2454 s_3084[erm] + s_3117[erm] -> s_2783[erm] + s_3108[erm] + s_3118[erm] YPR113W 0.00 1000.00 0.00 -r_2455 s_3085[erm] + s_3117[erm] -> s_2783[erm] + s_3108[erm] + s_3119[erm] YPR113W 0.00 1000.00 0.00 -r_2456 s_3086[erm] + s_3117[erm] -> s_2783[erm] + s_3108[erm] + s_3120[erm] YPR113W 0.00 1000.00 0.00 -r_2457 s_3087[erm] + s_3117[erm] -> s_2783[erm] + s_3108[erm] + s_3121[erm] YPR113W 0.00 1000.00 0.00 -r_2458 s_3088[erm] + s_3117[erm] -> s_2783[erm] + s_3108[erm] + s_3122[erm] YPR113W 0.00 1000.00 0.00 -r_2459 s_3089[erm] + s_3117[erm] -> s_2783[erm] + s_3108[erm] + s_3123[erm] YPR113W 0.00 1000.00 0.00 -r_2460 s_3090[erm] + s_3117[erm] -> s_2783[erm] + s_3108[erm] + s_3124[erm] YPR113W 0.00 1000.00 0.00 -r_2461 s_3091[erm] + s_3117[erm] -> s_2783[erm] + s_3108[erm] + s_3125[erm] YPR113W 0.00 1000.00 0.00 +r_2446 s_3084[erm] + s_3107[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3109[erm] YER026C 0.00 1000.00 0.00 +r_2447 s_3085[erm] + s_3107[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3110[erm] YER026C 0.00 1000.00 0.00 +r_2448 s_3086[erm] + s_3107[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3111[erm] YER026C 0.00 1000.00 0.00 +r_2449 s_3087[erm] + s_3107[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3112[erm] YER026C 0.00 1000.00 0.00 +r_2450 s_3088[erm] + s_3107[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3113[erm] YER026C 0.00 1000.00 0.00 +r_2451 s_3089[erm] + s_3107[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3114[erm] YER026C 0.00 1000.00 0.00 +r_2452 s_3090[erm] + s_3107[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3115[erm] YER026C 0.00 1000.00 0.00 +r_2453 s_3091[erm] + s_3107[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3116[erm] YER026C 0.00 1000.00 0.00 +r_2454 s_3084[erm] + s_3117[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3118[erm] YPR113W 0.00 1000.00 0.00 +r_2455 s_3085[erm] + s_3117[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3119[erm] YPR113W 0.00 1000.00 0.00 +r_2456 s_3086[erm] + s_3117[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3120[erm] YPR113W 0.00 1000.00 0.00 +r_2457 s_3087[erm] + s_3117[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3121[erm] YPR113W 0.00 1000.00 0.00 +r_2458 s_3088[erm] + s_3117[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3122[erm] YPR113W 0.00 1000.00 0.00 +r_2459 s_3089[erm] + s_3117[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3123[erm] YPR113W 0.00 1000.00 0.00 +r_2460 s_3090[erm] + s_3117[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3124[erm] YPR113W 0.00 1000.00 0.00 +r_2461 s_3091[erm] + s_3117[erm] -> 2 s_2783[erm] + s_3108[erm] + s_3125[erm] YPR113W 0.00 1000.00 0.00 r_2462 s_2791[erm] + s_3126[erm] <=> s_2785[erm] + s_3120[erm] YBR042C -1000.00 1000.00 0.00 r_2463 s_2791[erm] + s_3127[erm] <=> s_2785[erm] + s_3124[erm] YBR042C -1000.00 1000.00 0.00 -r_2464 s_3094[mm] + s_3128[mm] -> s_3129[mm] + s_3130[mm] YNL169C 0.00 1000.00 0.00 -r_2465 s_3094[mm] + s_3131[mm] -> s_3129[mm] + s_3132[mm] YNL169C 0.00 1000.00 0.00 -r_2466 s_3094[mm] + s_3133[mm] -> s_3129[mm] + s_3134[mm] YNL169C 0.00 1000.00 0.00 -r_2467 s_3094[mm] + s_3135[mm] -> s_3129[mm] + s_3136[mm] YNL169C 0.00 1000.00 0.00 -r_2468 s_3094[mm] + s_3137[mm] -> s_3129[mm] + s_3138[mm] YNL169C 0.00 1000.00 0.00 -r_2469 s_3094[mm] + s_3139[mm] -> s_3129[mm] + s_3140[mm] YNL169C 0.00 1000.00 0.00 -r_2470 s_3094[mm] + s_3141[mm] -> s_3129[mm] + s_3142[mm] YNL169C 0.00 1000.00 0.00 -r_2471 s_3094[mm] + s_3143[mm] -> s_3129[mm] + s_3144[mm] YNL169C 0.00 1000.00 0.00 -r_2472 s_3145[gm] + s_3146[gm] -> s_3147[gm] + s_3148[gm] YGR170W 0.00 1000.00 0.00 -r_2473 s_3146[gm] + s_3149[gm] -> s_3147[gm] + s_3150[gm] YGR170W 0.00 1000.00 0.00 -r_2474 s_3146[gm] + s_3151[gm] -> s_3147[gm] + s_3152[gm] YGR170W 0.00 1000.00 0.00 -r_2475 s_3146[gm] + s_3153[gm] -> s_3147[gm] + s_3154[gm] YGR170W 0.00 1000.00 0.00 -r_2476 s_3146[gm] + s_3155[gm] -> s_3147[gm] + s_3156[gm] YGR170W 0.00 1000.00 0.00 -r_2477 s_3146[gm] + s_3157[gm] -> s_3147[gm] + s_3158[gm] YGR170W 0.00 1000.00 0.00 -r_2478 s_3146[gm] + s_3159[gm] -> s_3147[gm] + s_3160[gm] YGR170W 0.00 1000.00 0.00 -r_2479 s_3146[gm] + s_3161[gm] -> s_3147[gm] + s_3162[gm] YGR170W 0.00 1000.00 0.00 -r_2480 s_3163[vm] + s_3164[vm] -> s_3165[vm] + s_3166[vm] YGR170W 0.00 1000.00 0.00 -r_2481 s_3164[vm] + s_3167[vm] -> s_3165[vm] + s_3168[vm] YGR170W 0.00 1000.00 0.00 -r_2482 s_3164[vm] + s_3169[vm] -> s_3165[vm] + s_3170[vm] YGR170W 0.00 1000.00 0.00 -r_2483 s_3164[vm] + s_3171[vm] -> s_3165[vm] + s_3172[vm] YGR170W 0.00 1000.00 0.00 -r_2484 s_3164[vm] + s_3173[vm] -> s_3165[vm] + s_3174[vm] YGR170W 0.00 1000.00 0.00 -r_2485 s_3164[vm] + s_3175[vm] -> s_3165[vm] + s_3176[vm] YGR170W 0.00 1000.00 0.00 -r_2486 s_3164[vm] + s_3177[vm] -> s_3165[vm] + s_3178[vm] YGR170W 0.00 1000.00 0.00 -r_2487 s_3164[vm] + s_3179[vm] -> s_3165[vm] + s_3180[vm] YGR170W 0.00 1000.00 0.00 +r_2464 s_3128[mm] -> s_3129[mm] + s_3130[mm] YNL169C 0.00 1000.00 0.00 +r_2465 s_3131[mm] -> s_3129[mm] + s_3132[mm] YNL169C 0.00 1000.00 0.00 +r_2466 s_3133[mm] -> s_3129[mm] + s_3134[mm] YNL169C 0.00 1000.00 0.00 +r_2467 s_3135[mm] -> s_3129[mm] + s_3136[mm] YNL169C 0.00 1000.00 0.00 +r_2468 s_3137[mm] -> s_3129[mm] + s_3138[mm] YNL169C 0.00 1000.00 0.00 +r_2469 s_3139[mm] -> s_3129[mm] + s_3140[mm] YNL169C 0.00 1000.00 0.00 +r_2470 s_3141[mm] -> s_3129[mm] + s_3142[mm] YNL169C 0.00 1000.00 0.00 +r_2471 s_3143[mm] -> s_3129[mm] + s_3144[mm] YNL169C 0.00 1000.00 0.00 +r_2472 s_3145[gm] -> s_3147[gm] + s_3148[gm] YGR170W 0.00 1000.00 0.00 +r_2473 s_3149[gm] -> s_3147[gm] + s_3150[gm] YGR170W 0.00 1000.00 0.00 +r_2474 s_3151[gm] -> s_3147[gm] + s_3152[gm] YGR170W 0.00 1000.00 0.00 +r_2475 s_3153[gm] -> s_3147[gm] + s_3154[gm] YGR170W 0.00 1000.00 0.00 +r_2476 s_3155[gm] -> s_3147[gm] + s_3156[gm] YGR170W 0.00 1000.00 0.00 +r_2477 s_3157[gm] -> s_3147[gm] + s_3158[gm] YGR170W 0.00 1000.00 0.00 +r_2478 s_3159[gm] -> s_3147[gm] + s_3160[gm] YGR170W 0.00 1000.00 0.00 +r_2479 s_3161[gm] -> s_3147[gm] + s_3162[gm] YGR170W 0.00 1000.00 0.00 +r_2480 s_3163[vm] -> s_3165[vm] + s_3166[vm] YGR170W 0.00 1000.00 0.00 +r_2481 s_3167[vm] -> s_3165[vm] + s_3168[vm] YGR170W 0.00 1000.00 0.00 +r_2482 s_3169[vm] -> s_3165[vm] + s_3170[vm] YGR170W 0.00 1000.00 0.00 +r_2483 s_3171[vm] -> s_3165[vm] + s_3172[vm] YGR170W 0.00 1000.00 0.00 +r_2484 s_3173[vm] -> s_3165[vm] + s_3174[vm] YGR170W 0.00 1000.00 0.00 +r_2485 s_3175[vm] -> s_3165[vm] + s_3176[vm] YGR170W 0.00 1000.00 0.00 +r_2486 s_3177[vm] -> s_3165[vm] + s_3178[vm] YGR170W 0.00 1000.00 0.00 +r_2487 s_3179[vm] -> s_3165[vm] + s_3180[vm] YGR170W 0.00 1000.00 0.00 r_2488 s_3181[erm] + s_3182[erm] -> s_2783[erm] + s_3183[erm] + s_3184[erm] ( YGR157W or YJR073C ) 0.00 1000.00 0.00 r_2489 s_3182[erm] + s_3185[erm] -> s_2783[erm] + s_3183[erm] + s_3186[erm] ( YGR157W or YJR073C ) 0.00 1000.00 0.00 r_2490 s_3182[erm] + s_3187[erm] -> s_2783[erm] + s_3183[erm] + s_3188[erm] ( YGR157W or YJR073C ) 0.00 1000.00 0.00 @@ -1202,14 +1202,14 @@ r_2508 s_3182[erm] + s_3203[erm] -> s_2783[erm] + s_3183[erm] + s_3211[erm] YJ r_2509 s_3182[erm] + s_3204[erm] -> s_2783[erm] + s_3183[erm] + s_3212[erm] YJR073C 0.00 1000.00 0.00 r_2510 s_3182[erm] + s_3205[erm] -> s_2783[erm] + s_3183[erm] + s_3213[erm] YJR073C 0.00 1000.00 0.00 r_2511 s_3182[erm] + s_3206[erm] -> s_2783[erm] + s_3183[erm] + s_3214[erm] YJR073C 0.00 1000.00 0.00 -r_2512 s_2967[erm] + s_3083[erm] -> s_2783[erm] + s_2954[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 -r_2513 s_2969[erm] + s_3083[erm] -> s_2783[erm] + s_2956[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 -r_2514 s_2971[erm] + s_3083[erm] -> s_2783[erm] + s_2958[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 -r_2515 s_2973[erm] + s_3083[erm] -> s_2783[erm] + s_2960[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 -r_2516 s_2968[erm] + s_3083[erm] -> s_2783[erm] + s_2955[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 -r_2517 s_2970[erm] + s_3083[erm] -> s_2783[erm] + s_2957[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 -r_2518 s_2972[erm] + s_3083[erm] -> s_2783[erm] + s_2959[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 -r_2519 s_2974[erm] + s_3083[erm] -> s_2783[erm] + s_2961[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 +r_2512 s_2783[erm] + s_2967[erm] + s_3083[erm] -> s_2954[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 +r_2513 s_2783[erm] + s_2969[erm] + s_3083[erm] -> s_2956[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 +r_2514 s_2783[erm] + s_2971[erm] + s_3083[erm] -> s_2958[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 +r_2515 s_2783[erm] + s_2973[erm] + s_3083[erm] -> s_2960[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 +r_2516 s_2783[erm] + s_2968[erm] + s_3083[erm] -> s_2955[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 +r_2517 s_2783[erm] + s_2970[erm] + s_3083[erm] -> s_2957[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 +r_2518 s_2783[erm] + s_2972[erm] + s_3083[erm] -> s_2959[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 +r_2519 s_2783[erm] + s_2974[erm] + s_3083[erm] -> s_2961[erm] + s_3215[erm] YOR311C 0.00 1000.00 0.00 r_2520 s_2967[erm] + s_3216[erm] -> s_2783[erm] + s_3108[erm] + s_3181[erm] YHR123W 0.00 1000.00 0.00 r_2521 s_2969[erm] + s_3216[erm] -> s_2783[erm] + s_3108[erm] + s_3185[erm] YHR123W 0.00 1000.00 0.00 r_2522 s_2971[erm] + s_3216[erm] -> s_2783[erm] + s_3108[erm] + s_3187[erm] YHR123W 0.00 1000.00 0.00 @@ -1226,54 +1226,54 @@ r_2532 s_2968[erm] + s_3217[erm] -> s_2783[erm] + s_3108[erm] + s_3211[erm] ( r_2533 s_2970[erm] + s_3217[erm] -> s_2783[erm] + s_3108[erm] + s_3212[erm] ( YHR123W or YNL130C ) 0.00 1000.00 0.00 r_2534 s_2972[erm] + s_3217[erm] -> s_2783[erm] + s_3108[erm] + s_3213[erm] ( YHR123W or YNL130C ) 0.00 1000.00 0.00 r_2535 s_2974[erm] + s_3217[erm] -> s_2783[erm] + s_3108[erm] + s_3214[erm] ( YHR123W or YNL130C ) 0.00 1000.00 0.00 -r_2536 s_3096[mm] + s_3218[mm] -> s_3094[mm] + s_3219[mm] + s_3220[mm] YCL004W 0.00 1000.00 0.00 -r_2537 s_3098[mm] + s_3218[mm] -> s_3094[mm] + s_3219[mm] + s_3221[mm] YCL004W 0.00 1000.00 0.00 -r_2538 s_3100[mm] + s_3218[mm] -> s_3094[mm] + s_3219[mm] + s_3222[mm] YCL004W 0.00 1000.00 0.00 -r_2539 s_3102[mm] + s_3218[mm] -> s_3094[mm] + s_3219[mm] + s_3223[mm] YCL004W 0.00 1000.00 0.00 -r_2540 s_3104[mm] + s_3218[mm] -> s_3094[mm] + s_3219[mm] + s_3224[mm] YCL004W 0.00 1000.00 0.00 -r_2541 s_3106[mm] + s_3218[mm] -> s_3094[mm] + s_3219[mm] + s_3225[mm] YCL004W 0.00 1000.00 0.00 -r_2542 s_3220[mm] + s_3226[mm] -> s_3227[mm] + s_3228[mm] YHR100C 0.00 1000.00 0.00 -r_2543 s_3221[mm] + s_3226[mm] -> s_3228[mm] + s_3229[mm] YHR100C 0.00 1000.00 0.00 -r_2544 s_3222[mm] + s_3226[mm] -> s_3228[mm] + s_3230[mm] YHR100C 0.00 1000.00 0.00 -r_2545 s_3223[mm] + s_3226[mm] -> s_3228[mm] + s_3231[mm] YHR100C 0.00 1000.00 0.00 -r_2546 s_3224[mm] + s_3226[mm] -> s_3228[mm] + s_3232[mm] YHR100C 0.00 1000.00 0.00 -r_2547 s_3225[mm] + s_3226[mm] -> s_3228[mm] + s_3233[mm] YHR100C 0.00 1000.00 0.00 -r_2548 s_3096[mm] + s_3227[mm] -> s_3094[mm] + s_3219[mm] + s_3234[mm] YDL142C 0.00 1000.00 0.00 -r_2549 s_3096[mm] + s_3229[mm] -> s_3094[mm] + s_3219[mm] + s_3235[mm] YDL142C 0.00 1000.00 0.00 -r_2550 s_3096[mm] + s_3230[mm] -> s_3094[mm] + s_3219[mm] + s_3236[mm] YDL142C 0.00 1000.00 0.00 -r_2551 s_3096[mm] + s_3231[mm] -> s_3094[mm] + s_3219[mm] + s_3237[mm] YDL142C 0.00 1000.00 0.00 -r_2552 s_3096[mm] + s_3232[mm] -> s_3094[mm] + s_3219[mm] + s_3238[mm] YDL142C 0.00 1000.00 0.00 -r_2553 s_3096[mm] + s_3233[mm] -> s_3094[mm] + s_3219[mm] + s_3239[mm] YDL142C 0.00 1000.00 0.00 -r_2554 s_3098[mm] + s_3227[mm] -> s_3094[mm] + s_3219[mm] + s_3240[mm] YDL142C 0.00 1000.00 0.00 -r_2555 s_3098[mm] + s_3229[mm] -> s_3094[mm] + s_3219[mm] + s_3241[mm] YDL142C 0.00 1000.00 0.00 -r_2556 s_3098[mm] + s_3230[mm] -> s_3094[mm] + s_3219[mm] + s_3242[mm] YDL142C 0.00 1000.00 0.00 -r_2557 s_3098[mm] + s_3231[mm] -> s_3094[mm] + s_3219[mm] + s_3243[mm] YDL142C 0.00 1000.00 0.00 -r_2558 s_3098[mm] + s_3232[mm] -> s_3094[mm] + s_3219[mm] + s_3244[mm] YDL142C 0.00 1000.00 0.00 -r_2559 s_3098[mm] + s_3233[mm] -> s_3094[mm] + s_3219[mm] + s_3245[mm] YDL142C 0.00 1000.00 0.00 -r_2560 s_3100[mm] + s_3227[mm] -> s_3094[mm] + s_3219[mm] + s_3246[mm] YDL142C 0.00 1000.00 0.00 -r_2561 s_3100[mm] + s_3229[mm] -> s_3094[mm] + s_3219[mm] + s_3247[mm] YDL142C 0.00 1000.00 0.00 -r_2562 s_3100[mm] + s_3230[mm] -> s_3094[mm] + s_3219[mm] + s_3248[mm] YDL142C 0.00 1000.00 0.00 -r_2563 s_3100[mm] + s_3231[mm] -> s_3094[mm] + s_3219[mm] + s_3249[mm] YDL142C 0.00 1000.00 0.00 -r_2564 s_3100[mm] + s_3232[mm] -> s_3094[mm] + s_3219[mm] + s_3250[mm] YDL142C 0.00 1000.00 0.00 -r_2565 s_3100[mm] + s_3233[mm] -> s_3094[mm] + s_3219[mm] + s_3251[mm] YDL142C 0.00 1000.00 0.00 -r_2566 s_3102[mm] + s_3227[mm] -> s_3094[mm] + s_3219[mm] + s_3252[mm] YDL142C 0.00 1000.00 0.00 -r_2567 s_3102[mm] + s_3229[mm] -> s_3094[mm] + s_3219[mm] + s_3253[mm] YDL142C 0.00 1000.00 0.00 -r_2568 s_3102[mm] + s_3230[mm] -> s_3094[mm] + s_3219[mm] + s_3254[mm] YDL142C 0.00 1000.00 0.00 -r_2569 s_3102[mm] + s_3231[mm] -> s_3094[mm] + s_3219[mm] + s_3255[mm] YDL142C 0.00 1000.00 0.00 -r_2570 s_3102[mm] + s_3232[mm] -> s_3094[mm] + s_3219[mm] + s_3256[mm] YDL142C 0.00 1000.00 0.00 -r_2571 s_3102[mm] + s_3233[mm] -> s_3094[mm] + s_3219[mm] + s_3257[mm] YDL142C 0.00 1000.00 0.00 -r_2572 s_3104[mm] + s_3227[mm] -> s_3094[mm] + s_3219[mm] + s_3258[mm] YDL142C 0.00 1000.00 0.00 -r_2573 s_3104[mm] + s_3229[mm] -> s_3094[mm] + s_3219[mm] + s_3259[mm] YDL142C 0.00 1000.00 0.00 -r_2574 s_3104[mm] + s_3230[mm] -> s_3094[mm] + s_3219[mm] + s_3260[mm] YDL142C 0.00 1000.00 0.00 -r_2575 s_3104[mm] + s_3231[mm] -> s_3094[mm] + s_3219[mm] + s_3261[mm] YDL142C 0.00 1000.00 0.00 -r_2576 s_3104[mm] + s_3232[mm] -> s_3094[mm] + s_3219[mm] + s_3262[mm] YDL142C 0.00 1000.00 0.00 -r_2577 s_3104[mm] + s_3233[mm] -> s_3094[mm] + s_3219[mm] + s_3263[mm] YDL142C 0.00 1000.00 0.00 -r_2578 s_3106[mm] + s_3227[mm] -> s_3094[mm] + s_3219[mm] + s_3264[mm] YDL142C 0.00 1000.00 0.00 -r_2579 s_3106[mm] + s_3229[mm] -> s_3094[mm] + s_3219[mm] + s_3265[mm] YDL142C 0.00 1000.00 0.00 -r_2580 s_3106[mm] + s_3230[mm] -> s_3094[mm] + s_3219[mm] + s_3266[mm] YDL142C 0.00 1000.00 0.00 -r_2581 s_3106[mm] + s_3231[mm] -> s_3094[mm] + s_3219[mm] + s_3267[mm] YDL142C 0.00 1000.00 0.00 -r_2582 s_3106[mm] + s_3232[mm] -> s_3094[mm] + s_3219[mm] + s_3268[mm] YDL142C 0.00 1000.00 0.00 -r_2583 s_3106[mm] + s_3233[mm] -> s_3094[mm] + s_3219[mm] + s_3269[mm] YDL142C 0.00 1000.00 0.00 +r_2536 s_3096[mm] + s_3218[mm] -> s_3219[mm] + s_3220[mm] YCL004W 0.00 1000.00 0.00 +r_2537 s_3098[mm] + s_3218[mm] -> s_3219[mm] + s_3221[mm] YCL004W 0.00 1000.00 0.00 +r_2538 s_3100[mm] + s_3218[mm] -> s_3219[mm] + s_3222[mm] YCL004W 0.00 1000.00 0.00 +r_2539 s_3102[mm] + s_3218[mm] -> s_3219[mm] + s_3223[mm] YCL004W 0.00 1000.00 0.00 +r_2540 s_3104[mm] + s_3218[mm] -> s_3219[mm] + s_3224[mm] YCL004W 0.00 1000.00 0.00 +r_2541 s_3106[mm] + s_3218[mm] -> s_3219[mm] + s_3225[mm] YCL004W 0.00 1000.00 0.00 +r_2542 s_3220[mm] + s_3226[mm] -> 2 s_3094[mm] + s_3227[mm] + s_3228[mm] YHR100C 0.00 1000.00 0.00 +r_2543 s_3221[mm] + s_3226[mm] -> 2 s_3094[mm] + s_3228[mm] + s_3229[mm] YHR100C 0.00 1000.00 0.00 +r_2544 s_3222[mm] + s_3226[mm] -> 2 s_3094[mm] + s_3228[mm] + s_3230[mm] YHR100C 0.00 1000.00 0.00 +r_2545 s_3223[mm] + s_3226[mm] -> 2 s_3094[mm] + s_3228[mm] + s_3231[mm] YHR100C 0.00 1000.00 0.00 +r_2546 s_3224[mm] + s_3226[mm] -> 2 s_3094[mm] + s_3228[mm] + s_3232[mm] YHR100C 0.00 1000.00 0.00 +r_2547 s_3225[mm] + s_3226[mm] -> 2 s_3094[mm] + s_3228[mm] + s_3233[mm] YHR100C 0.00 1000.00 0.00 +r_2548 s_3096[mm] + s_3227[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3234[mm] YDL142C 0.00 1000.00 0.00 +r_2549 s_3096[mm] + s_3229[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3235[mm] YDL142C 0.00 1000.00 0.00 +r_2550 s_3096[mm] + s_3230[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3236[mm] YDL142C 0.00 1000.00 0.00 +r_2551 s_3096[mm] + s_3231[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3237[mm] YDL142C 0.00 1000.00 0.00 +r_2552 s_3096[mm] + s_3232[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3238[mm] YDL142C 0.00 1000.00 0.00 +r_2553 s_3096[mm] + s_3233[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3239[mm] YDL142C 0.00 1000.00 0.00 +r_2554 s_3098[mm] + s_3227[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3240[mm] YDL142C 0.00 1000.00 0.00 +r_2555 s_3098[mm] + s_3229[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3241[mm] YDL142C 0.00 1000.00 0.00 +r_2556 s_3098[mm] + s_3230[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3242[mm] YDL142C 0.00 1000.00 0.00 +r_2557 s_3098[mm] + s_3231[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3243[mm] YDL142C 0.00 1000.00 0.00 +r_2558 s_3098[mm] + s_3232[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3244[mm] YDL142C 0.00 1000.00 0.00 +r_2559 s_3098[mm] + s_3233[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3245[mm] YDL142C 0.00 1000.00 0.00 +r_2560 s_3100[mm] + s_3227[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3246[mm] YDL142C 0.00 1000.00 0.00 +r_2561 s_3100[mm] + s_3229[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3247[mm] YDL142C 0.00 1000.00 0.00 +r_2562 s_3100[mm] + s_3230[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3248[mm] YDL142C 0.00 1000.00 0.00 +r_2563 s_3100[mm] + s_3231[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3249[mm] YDL142C 0.00 1000.00 0.00 +r_2564 s_3100[mm] + s_3232[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3250[mm] YDL142C 0.00 1000.00 0.00 +r_2565 s_3100[mm] + s_3233[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3251[mm] YDL142C 0.00 1000.00 0.00 +r_2566 s_3102[mm] + s_3227[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3252[mm] YDL142C 0.00 1000.00 0.00 +r_2567 s_3102[mm] + s_3229[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3253[mm] YDL142C 0.00 1000.00 0.00 +r_2568 s_3102[mm] + s_3230[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3254[mm] YDL142C 0.00 1000.00 0.00 +r_2569 s_3102[mm] + s_3231[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3255[mm] YDL142C 0.00 1000.00 0.00 +r_2570 s_3102[mm] + s_3232[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3256[mm] YDL142C 0.00 1000.00 0.00 +r_2571 s_3102[mm] + s_3233[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3257[mm] YDL142C 0.00 1000.00 0.00 +r_2572 s_3104[mm] + s_3227[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3258[mm] YDL142C 0.00 1000.00 0.00 +r_2573 s_3104[mm] + s_3229[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3259[mm] YDL142C 0.00 1000.00 0.00 +r_2574 s_3104[mm] + s_3230[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3260[mm] YDL142C 0.00 1000.00 0.00 +r_2575 s_3104[mm] + s_3231[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3261[mm] YDL142C 0.00 1000.00 0.00 +r_2576 s_3104[mm] + s_3232[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3262[mm] YDL142C 0.00 1000.00 0.00 +r_2577 s_3104[mm] + s_3233[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3263[mm] YDL142C 0.00 1000.00 0.00 +r_2578 s_3106[mm] + s_3227[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3264[mm] YDL142C 0.00 1000.00 0.00 +r_2579 s_3106[mm] + s_3229[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3265[mm] YDL142C 0.00 1000.00 0.00 +r_2580 s_3106[mm] + s_3230[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3266[mm] YDL142C 0.00 1000.00 0.00 +r_2581 s_3106[mm] + s_3231[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3267[mm] YDL142C 0.00 1000.00 0.00 +r_2582 s_3106[mm] + s_3232[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3268[mm] YDL142C 0.00 1000.00 0.00 +r_2583 s_3106[mm] + s_3233[mm] -> 2 s_3094[mm] + s_3219[mm] + s_3269[mm] YDL142C 0.00 1000.00 0.00 r_2584 s_3226[mm] + s_3234[mm] -> s_3094[mm] + s_3270[mm] + s_3271[mm] YGR110W 0.00 1000.00 0.00 r_2585 s_3226[mm] + s_3235[mm] -> s_3094[mm] + s_3271[mm] + s_3272[mm] YGR110W 0.00 1000.00 0.00 r_2586 s_3226[mm] + s_3236[mm] -> s_3094[mm] + s_3271[mm] + s_3273[mm] YGR110W 0.00 1000.00 0.00 @@ -1502,70 +1502,70 @@ r_2808 s_3295[mm] + s_3304[mm] <=> s_3297[mm] + s_3319[mm] YPR140W -1000.00 10 r_2809 s_3295[mm] + s_3305[mm] <=> s_3299[mm] + s_3319[mm] YPR140W -1000.00 1000.00 0.00 r_2810 s_3295[mm] + s_3306[mm] <=> s_3301[mm] + s_3319[mm] YPR140W -1000.00 1000.00 0.00 r_2811 s_3295[mm] + s_3307[mm] <=> s_3303[mm] + s_3319[mm] YPR140W -1000.00 1000.00 0.00 -r_2820 s_2856[ce] + s_3323[ce] -> s_0793[ce] + s_3324[ce] + s_3325[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 -r_2821 s_2856[ce] + s_3326[ce] -> s_0793[ce] + s_3324[ce] + s_3327[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 -r_2822 s_2856[ce] + s_3328[ce] -> s_0793[ce] + s_3324[ce] + s_3329[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 -r_2823 s_2856[ce] + s_3330[ce] -> s_0793[ce] + s_3324[ce] + s_3331[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 -r_2824 s_2856[ce] + s_3332[ce] -> s_0793[ce] + s_3324[ce] + s_3333[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 -r_2825 s_2856[ce] + s_3334[ce] -> s_0793[ce] + s_3324[ce] + s_3335[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 -r_2826 s_2856[ce] + s_3336[ce] -> s_0793[ce] + s_3324[ce] + s_3337[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 -r_2827 s_2856[ce] + s_3338[ce] -> s_0793[ce] + s_3324[ce] + s_3339[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 -r_2828 s_3340[vm] + s_3341[vm] -> s_3164[vm] + s_3342[vm] + s_3343[vm] YJL100W 0.00 1000.00 0.00 -r_2829 s_3341[vm] + s_3344[vm] -> s_3164[vm] + s_3342[vm] + s_3345[vm] YJL100W 0.00 1000.00 0.00 -r_2830 s_3341[vm] + s_3346[vm] -> s_3164[vm] + s_3342[vm] + s_3347[vm] YJL100W 0.00 1000.00 0.00 -r_2831 s_3341[vm] + s_3348[vm] -> s_3164[vm] + s_3342[vm] + s_3349[vm] YJL100W 0.00 1000.00 0.00 -r_2832 s_3341[vm] + s_3350[vm] -> s_3164[vm] + s_3342[vm] + s_3351[vm] YJL100W 0.00 1000.00 0.00 -r_2833 s_3341[vm] + s_3352[vm] -> s_3164[vm] + s_3342[vm] + s_3353[vm] YJL100W 0.00 1000.00 0.00 -r_2834 s_3341[vm] + s_3354[vm] -> s_3164[vm] + s_3342[vm] + s_3355[vm] YJL100W 0.00 1000.00 0.00 -r_2835 s_3341[vm] + s_3356[vm] -> s_3164[vm] + s_3342[vm] + s_3357[vm] YJL100W 0.00 1000.00 0.00 -r_2836 s_3358[gm] + s_3359[gm] -> s_3146[gm] + s_3360[gm] + s_3361[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 -r_2837 s_3359[gm] + s_3362[gm] -> s_3146[gm] + s_3360[gm] + s_3363[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 -r_2838 s_3359[gm] + s_3364[gm] -> s_3146[gm] + s_3360[gm] + s_3365[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 -r_2839 s_3359[gm] + s_3366[gm] -> s_3146[gm] + s_3360[gm] + s_3367[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 -r_2840 s_3359[gm] + s_3368[gm] -> s_3146[gm] + s_3360[gm] + s_3369[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 -r_2841 s_3359[gm] + s_3370[gm] -> s_3146[gm] + s_3360[gm] + s_3371[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 -r_2842 s_3359[gm] + s_3372[gm] -> s_3146[gm] + s_3360[gm] + s_3373[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 -r_2843 s_3359[gm] + s_3374[gm] -> s_3146[gm] + s_3360[gm] + s_3375[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 -r_2844 s_0438[n] + s_3376[n] -> s_0398[n] + s_0800[n] + s_3377[n] YNL267W 0.00 1000.00 0.00 -r_2845 s_0438[n] + s_3378[n] -> s_0398[n] + s_0800[n] + s_3379[n] YNL267W 0.00 1000.00 0.00 -r_2846 s_0438[n] + s_3380[n] -> s_0398[n] + s_0800[n] + s_3381[n] YNL267W 0.00 1000.00 0.00 -r_2847 s_0438[n] + s_3382[n] -> s_0398[n] + s_0800[n] + s_3383[n] YNL267W 0.00 1000.00 0.00 -r_2848 s_0438[n] + s_3384[n] -> s_0398[n] + s_0800[n] + s_3385[n] YNL267W 0.00 1000.00 0.00 -r_2849 s_0438[n] + s_3386[n] -> s_0398[n] + s_0800[n] + s_3387[n] YNL267W 0.00 1000.00 0.00 -r_2850 s_0438[n] + s_3388[n] -> s_0398[n] + s_0800[n] + s_3389[n] YNL267W 0.00 1000.00 0.00 -r_2851 s_0438[n] + s_3390[n] -> s_0398[n] + s_0800[n] + s_3391[n] YNL267W 0.00 1000.00 0.00 -r_2852 s_3340[vm] + s_3341[vm] -> s_3164[vm] + s_3342[vm] + s_3392[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 -r_2853 s_3341[vm] + s_3344[vm] -> s_3164[vm] + s_3342[vm] + s_3393[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 -r_2854 s_3341[vm] + s_3346[vm] -> s_3164[vm] + s_3342[vm] + s_3394[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 -r_2855 s_3341[vm] + s_3348[vm] -> s_3164[vm] + s_3342[vm] + s_3395[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 -r_2856 s_3341[vm] + s_3350[vm] -> s_3164[vm] + s_3342[vm] + s_3396[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 -r_2857 s_3341[vm] + s_3352[vm] -> s_3164[vm] + s_3342[vm] + s_3397[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 -r_2858 s_3341[vm] + s_3354[vm] -> s_3164[vm] + s_3342[vm] + s_3398[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 -r_2859 s_3341[vm] + s_3356[vm] -> s_3164[vm] + s_3342[vm] + s_3399[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 -r_2860 s_0438[n] + s_3377[n] -> s_0398[n] + s_0800[n] + s_3400[n] YDR208W 0.00 1000.00 0.00 -r_2861 s_0438[n] + s_3379[n] -> s_0398[n] + s_0800[n] + s_3401[n] YDR208W 0.00 1000.00 0.00 -r_2862 s_0438[n] + s_3381[n] -> s_0398[n] + s_0800[n] + s_3402[n] YDR208W 0.00 1000.00 0.00 -r_2863 s_0438[n] + s_3383[n] -> s_0398[n] + s_0800[n] + s_3403[n] YDR208W 0.00 1000.00 0.00 -r_2864 s_0438[n] + s_3385[n] -> s_0398[n] + s_0800[n] + s_3404[n] YDR208W 0.00 1000.00 0.00 -r_2865 s_0438[n] + s_3387[n] -> s_0398[n] + s_0800[n] + s_3405[n] YDR208W 0.00 1000.00 0.00 -r_2866 s_0438[n] + s_3389[n] -> s_0398[n] + s_0800[n] + s_3406[n] YDR208W 0.00 1000.00 0.00 -r_2867 s_0438[n] + s_3391[n] -> s_0398[n] + s_0800[n] + s_3407[n] YDR208W 0.00 1000.00 0.00 -r_2868 s_2856[ce] + s_3325[ce] -> s_0793[ce] + s_3324[ce] + s_3408[ce] YDR208W 0.00 1000.00 0.00 -r_2869 s_2856[ce] + s_3327[ce] -> s_0793[ce] + s_3324[ce] + s_3409[ce] YDR208W 0.00 1000.00 0.00 -r_2870 s_2856[ce] + s_3329[ce] -> s_0793[ce] + s_3324[ce] + s_3410[ce] YDR208W 0.00 1000.00 0.00 -r_2871 s_2856[ce] + s_3331[ce] -> s_0793[ce] + s_3324[ce] + s_3411[ce] YDR208W 0.00 1000.00 0.00 -r_2872 s_2856[ce] + s_3333[ce] -> s_0793[ce] + s_3324[ce] + s_3412[ce] YDR208W 0.00 1000.00 0.00 -r_2873 s_2856[ce] + s_3335[ce] -> s_0793[ce] + s_3324[ce] + s_3413[ce] YDR208W 0.00 1000.00 0.00 -r_2874 s_2856[ce] + s_3337[ce] -> s_0793[ce] + s_3324[ce] + s_3414[ce] YDR208W 0.00 1000.00 0.00 -r_2875 s_2856[ce] + s_3339[ce] -> s_0793[ce] + s_3324[ce] + s_3415[ce] YDR208W 0.00 1000.00 0.00 -r_2876 s_3341[vm] + s_3392[vm] -> s_3164[vm] + s_3342[vm] + s_3416[vm] YFR019W 0.00 1000.00 0.00 -r_2877 s_3341[vm] + s_3393[vm] -> s_3164[vm] + s_3342[vm] + s_3417[vm] YFR019W 0.00 1000.00 0.00 -r_2878 s_3341[vm] + s_3394[vm] -> s_3164[vm] + s_3342[vm] + s_3418[vm] YFR019W 0.00 1000.00 0.00 -r_2879 s_3341[vm] + s_3395[vm] -> s_3164[vm] + s_3342[vm] + s_3419[vm] YFR019W 0.00 1000.00 0.00 -r_2880 s_3341[vm] + s_3396[vm] -> s_3164[vm] + s_3342[vm] + s_3420[vm] YFR019W 0.00 1000.00 0.00 -r_2881 s_3341[vm] + s_3397[vm] -> s_3164[vm] + s_3342[vm] + s_3421[vm] YFR019W 0.00 1000.00 0.00 -r_2882 s_3341[vm] + s_3398[vm] -> s_3164[vm] + s_3342[vm] + s_3422[vm] YFR019W 0.00 1000.00 0.00 -r_2883 s_3341[vm] + s_3399[vm] -> s_3164[vm] + s_3342[vm] + s_3423[vm] YFR019W 0.00 1000.00 0.00 +r_2820 s_0793[ce] + s_2856[ce] + s_3323[ce] -> s_3324[ce] + s_3325[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 +r_2821 s_0793[ce] + s_2856[ce] + s_3326[ce] -> s_3324[ce] + s_3327[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 +r_2822 s_0793[ce] + s_2856[ce] + s_3328[ce] -> s_3324[ce] + s_3329[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 +r_2823 s_0793[ce] + s_2856[ce] + s_3330[ce] -> s_3324[ce] + s_3331[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 +r_2824 s_0793[ce] + s_2856[ce] + s_3332[ce] -> s_3324[ce] + s_3333[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 +r_2825 s_0793[ce] + s_2856[ce] + s_3334[ce] -> s_3324[ce] + s_3335[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 +r_2826 s_0793[ce] + s_2856[ce] + s_3336[ce] -> s_3324[ce] + s_3337[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 +r_2827 s_0793[ce] + s_2856[ce] + s_3338[ce] -> s_3324[ce] + s_3339[ce] ( YJL100W or YLR305C ) 0.00 1000.00 0.00 +r_2828 s_3164[vm] + s_3340[vm] + s_3341[vm] -> s_3342[vm] + s_3343[vm] YJL100W 0.00 1000.00 0.00 +r_2829 s_3164[vm] + s_3341[vm] + s_3344[vm] -> s_3342[vm] + s_3345[vm] YJL100W 0.00 1000.00 0.00 +r_2830 s_3164[vm] + s_3341[vm] + s_3346[vm] -> s_3342[vm] + s_3347[vm] YJL100W 0.00 1000.00 0.00 +r_2831 s_3164[vm] + s_3341[vm] + s_3348[vm] -> s_3342[vm] + s_3349[vm] YJL100W 0.00 1000.00 0.00 +r_2832 s_3164[vm] + s_3341[vm] + s_3350[vm] -> s_3342[vm] + s_3351[vm] YJL100W 0.00 1000.00 0.00 +r_2833 s_3164[vm] + s_3341[vm] + s_3352[vm] -> s_3342[vm] + s_3353[vm] YJL100W 0.00 1000.00 0.00 +r_2834 s_3164[vm] + s_3341[vm] + s_3354[vm] -> s_3342[vm] + s_3355[vm] YJL100W 0.00 1000.00 0.00 +r_2835 s_3164[vm] + s_3341[vm] + s_3356[vm] -> s_3342[vm] + s_3357[vm] YJL100W 0.00 1000.00 0.00 +r_2836 s_3146[gm] + s_3358[gm] + s_3359[gm] -> s_3360[gm] + s_3361[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 +r_2837 s_3146[gm] + s_3359[gm] + s_3362[gm] -> s_3360[gm] + s_3363[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 +r_2838 s_3146[gm] + s_3359[gm] + s_3364[gm] -> s_3360[gm] + s_3365[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 +r_2839 s_3146[gm] + s_3359[gm] + s_3366[gm] -> s_3360[gm] + s_3367[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 +r_2840 s_3146[gm] + s_3359[gm] + s_3368[gm] -> s_3360[gm] + s_3369[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 +r_2841 s_3146[gm] + s_3359[gm] + s_3370[gm] -> s_3360[gm] + s_3371[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 +r_2842 s_3146[gm] + s_3359[gm] + s_3372[gm] -> s_3360[gm] + s_3373[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 +r_2843 s_3146[gm] + s_3359[gm] + s_3374[gm] -> s_3360[gm] + s_3375[gm] ( YDR373W and YNL267W ) 0.00 1000.00 0.00 +r_2844 s_0438[n] + s_0800[n] + s_3376[n] -> s_0398[n] + s_3377[n] YNL267W 0.00 1000.00 0.00 +r_2845 s_0438[n] + s_0800[n] + s_3378[n] -> s_0398[n] + s_3379[n] YNL267W 0.00 1000.00 0.00 +r_2846 s_0438[n] + s_0800[n] + s_3380[n] -> s_0398[n] + s_3381[n] YNL267W 0.00 1000.00 0.00 +r_2847 s_0438[n] + s_0800[n] + s_3382[n] -> s_0398[n] + s_3383[n] YNL267W 0.00 1000.00 0.00 +r_2848 s_0438[n] + s_0800[n] + s_3384[n] -> s_0398[n] + s_3385[n] YNL267W 0.00 1000.00 0.00 +r_2849 s_0438[n] + s_0800[n] + s_3386[n] -> s_0398[n] + s_3387[n] YNL267W 0.00 1000.00 0.00 +r_2850 s_0438[n] + s_0800[n] + s_3388[n] -> s_0398[n] + s_3389[n] YNL267W 0.00 1000.00 0.00 +r_2851 s_0438[n] + s_0800[n] + s_3390[n] -> s_0398[n] + s_3391[n] YNL267W 0.00 1000.00 0.00 +r_2852 s_3164[vm] + s_3340[vm] + s_3341[vm] -> s_3342[vm] + s_3392[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 +r_2853 s_3164[vm] + s_3341[vm] + s_3344[vm] -> s_3342[vm] + s_3393[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 +r_2854 s_3164[vm] + s_3341[vm] + s_3346[vm] -> s_3342[vm] + s_3394[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 +r_2855 s_3164[vm] + s_3341[vm] + s_3348[vm] -> s_3342[vm] + s_3395[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 +r_2856 s_3164[vm] + s_3341[vm] + s_3350[vm] -> s_3342[vm] + s_3396[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 +r_2857 s_3164[vm] + s_3341[vm] + s_3352[vm] -> s_3342[vm] + s_3397[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 +r_2858 s_3164[vm] + s_3341[vm] + s_3354[vm] -> s_3342[vm] + s_3398[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 +r_2859 s_3164[vm] + s_3341[vm] + s_3356[vm] -> s_3342[vm] + s_3399[vm] ( YBR097W and YLR240W ) 0.00 1000.00 0.00 +r_2860 s_0438[n] + s_0800[n] + s_3377[n] -> s_0398[n] + s_3400[n] YDR208W 0.00 1000.00 0.00 +r_2861 s_0438[n] + s_0800[n] + s_3379[n] -> s_0398[n] + s_3401[n] YDR208W 0.00 1000.00 0.00 +r_2862 s_0438[n] + s_0800[n] + s_3381[n] -> s_0398[n] + s_3402[n] YDR208W 0.00 1000.00 0.00 +r_2863 s_0438[n] + s_0800[n] + s_3383[n] -> s_0398[n] + s_3403[n] YDR208W 0.00 1000.00 0.00 +r_2864 s_0438[n] + s_0800[n] + s_3385[n] -> s_0398[n] + s_3404[n] YDR208W 0.00 1000.00 0.00 +r_2865 s_0438[n] + s_0800[n] + s_3387[n] -> s_0398[n] + s_3405[n] YDR208W 0.00 1000.00 0.00 +r_2866 s_0438[n] + s_0800[n] + s_3389[n] -> s_0398[n] + s_3406[n] YDR208W 0.00 1000.00 0.00 +r_2867 s_0438[n] + s_0800[n] + s_3391[n] -> s_0398[n] + s_3407[n] YDR208W 0.00 1000.00 0.00 +r_2868 s_0793[ce] + s_2856[ce] + s_3325[ce] -> s_3324[ce] + s_3408[ce] YDR208W 0.00 1000.00 0.00 +r_2869 s_0793[ce] + s_2856[ce] + s_3327[ce] -> s_3324[ce] + s_3409[ce] YDR208W 0.00 1000.00 0.00 +r_2870 s_0793[ce] + s_2856[ce] + s_3329[ce] -> s_3324[ce] + s_3410[ce] YDR208W 0.00 1000.00 0.00 +r_2871 s_0793[ce] + s_2856[ce] + s_3331[ce] -> s_3324[ce] + s_3411[ce] YDR208W 0.00 1000.00 0.00 +r_2872 s_0793[ce] + s_2856[ce] + s_3333[ce] -> s_3324[ce] + s_3412[ce] YDR208W 0.00 1000.00 0.00 +r_2873 s_0793[ce] + s_2856[ce] + s_3335[ce] -> s_3324[ce] + s_3413[ce] YDR208W 0.00 1000.00 0.00 +r_2874 s_0793[ce] + s_2856[ce] + s_3337[ce] -> s_3324[ce] + s_3414[ce] YDR208W 0.00 1000.00 0.00 +r_2875 s_0793[ce] + s_2856[ce] + s_3339[ce] -> s_3324[ce] + s_3415[ce] YDR208W 0.00 1000.00 0.00 +r_2876 s_3164[vm] + s_3341[vm] + s_3392[vm] -> s_3342[vm] + s_3416[vm] YFR019W 0.00 1000.00 0.00 +r_2877 s_3164[vm] + s_3341[vm] + s_3393[vm] -> s_3342[vm] + s_3417[vm] YFR019W 0.00 1000.00 0.00 +r_2878 s_3164[vm] + s_3341[vm] + s_3394[vm] -> s_3342[vm] + s_3418[vm] YFR019W 0.00 1000.00 0.00 +r_2879 s_3164[vm] + s_3341[vm] + s_3395[vm] -> s_3342[vm] + s_3419[vm] YFR019W 0.00 1000.00 0.00 +r_2880 s_3164[vm] + s_3341[vm] + s_3396[vm] -> s_3342[vm] + s_3420[vm] YFR019W 0.00 1000.00 0.00 +r_2881 s_3164[vm] + s_3341[vm] + s_3397[vm] -> s_3342[vm] + s_3421[vm] YFR019W 0.00 1000.00 0.00 +r_2882 s_3164[vm] + s_3341[vm] + s_3398[vm] -> s_3342[vm] + s_3422[vm] YFR019W 0.00 1000.00 0.00 +r_2883 s_3164[vm] + s_3341[vm] + s_3399[vm] -> s_3342[vm] + s_3423[vm] YFR019W 0.00 1000.00 0.00 r_2884 s_2967[erm] + s_3181[erm] <=> s_3019[erm] + s_3424[erm] YNR008W -1000.00 1000.00 0.00 r_2885 s_2967[erm] + s_3185[erm] <=> s_3019[erm] + s_3425[erm] YNR008W -1000.00 1000.00 0.00 r_2886 s_2967[erm] + s_3187[erm] <=> s_3019[erm] + s_3426[erm] YNR008W -1000.00 1000.00 0.00 @@ -1750,180 +1750,180 @@ r_3074 s_3332[ce] + s_3449[ce] -> s_0793[ce] + s_3459[ce] + s_3491[ce] YOL011W r_3075 s_3334[ce] + s_3449[ce] -> s_0793[ce] + s_3459[ce] + s_3492[ce] YOL011W 0.00 1000.00 0.00 r_3076 s_3336[ce] + s_3449[ce] -> s_0793[ce] + s_3459[ce] + s_3493[ce] YOL011W 0.00 1000.00 0.00 r_3077 s_3338[ce] + s_3449[ce] -> s_0793[ce] + s_3459[ce] + s_3494[ce] YOL011W 0.00 1000.00 0.00 -r_3078 s_3449[ce] + s_3491[ce] -> s_0793[ce] + s_3463[ce] + s_3495[ce] YOL011W 0.00 1000.00 0.00 -r_3079 s_3449[ce] + s_3492[ce] -> s_0793[ce] + s_3451[ce] + s_3495[ce] YOL011W 0.00 1000.00 0.00 -r_3080 s_3449[ce] + s_3493[ce] -> s_0793[ce] + s_3464[ce] + s_3495[ce] YOL011W 0.00 1000.00 0.00 -r_3081 s_3449[ce] + s_3494[ce] -> s_0793[ce] + s_3459[ce] + s_3495[ce] YOL011W 0.00 1000.00 0.00 -r_3082 s_0803[c] + s_3496[c] -> s_0794[c] + s_3497[c] + s_3498[c] YPL268W 0.00 1000.00 0.00 -r_3083 s_0803[c] + s_3499[c] -> s_0794[c] + s_3498[c] + s_3500[c] YPL268W 0.00 1000.00 0.00 -r_3084 s_0803[c] + s_3501[c] -> s_0794[c] + s_3498[c] + s_3502[c] YPL268W 0.00 1000.00 0.00 -r_3085 s_0803[c] + s_3503[c] -> s_0794[c] + s_3498[c] + s_3504[c] YPL268W 0.00 1000.00 0.00 -r_3086 s_0803[c] + s_3505[c] -> s_0794[c] + s_3498[c] + s_3506[c] YPL268W 0.00 1000.00 0.00 -r_3087 s_0803[c] + s_3507[c] -> s_0794[c] + s_3498[c] + s_3508[c] YPL268W 0.00 1000.00 0.00 -r_3088 s_0803[c] + s_3509[c] -> s_0794[c] + s_3498[c] + s_3510[c] YPL268W 0.00 1000.00 0.00 -r_3089 s_0803[c] + s_3511[c] -> s_0794[c] + s_3498[c] + s_3512[c] YPL268W 0.00 1000.00 0.00 -r_3090 s_0808[n] + s_3400[n] -> s_0125[n] + s_0800[n] + s_3513[n] YPL268W 0.00 1000.00 0.00 -r_3091 s_0808[n] + s_3401[n] -> s_0125[n] + s_0800[n] + s_3514[n] YPL268W 0.00 1000.00 0.00 -r_3092 s_0808[n] + s_3402[n] -> s_0125[n] + s_0800[n] + s_3515[n] YPL268W 0.00 1000.00 0.00 -r_3093 s_0808[n] + s_3403[n] -> s_0125[n] + s_0800[n] + s_3516[n] YPL268W 0.00 1000.00 0.00 -r_3094 s_0808[n] + s_3404[n] -> s_0125[n] + s_0800[n] + s_3517[n] YPL268W 0.00 1000.00 0.00 -r_3095 s_0808[n] + s_3405[n] -> s_0125[n] + s_0800[n] + s_3518[n] YPL268W 0.00 1000.00 0.00 -r_3096 s_0808[n] + s_3406[n] -> s_0125[n] + s_0800[n] + s_3519[n] YPL268W 0.00 1000.00 0.00 -r_3097 s_0808[n] + s_3407[n] -> s_0125[n] + s_0800[n] + s_3520[n] YPL268W 0.00 1000.00 0.00 -r_3098 s_3226[mm] + s_3227[mm] -> s_3094[mm] + s_3218[mm] + s_3521[mm] YPL206C 0.00 1000.00 0.00 -r_3099 s_3226[mm] + s_3229[mm] -> s_3094[mm] + s_3218[mm] + s_3522[mm] YPL206C 0.00 1000.00 0.00 -r_3100 s_3226[mm] + s_3230[mm] -> s_3094[mm] + s_3218[mm] + s_3523[mm] YPL206C 0.00 1000.00 0.00 -r_3101 s_3226[mm] + s_3231[mm] -> s_3094[mm] + s_3218[mm] + s_3524[mm] YPL206C 0.00 1000.00 0.00 -r_3102 s_3226[mm] + s_3232[mm] -> s_3094[mm] + s_3218[mm] + s_3525[mm] YPL206C 0.00 1000.00 0.00 -r_3103 s_3226[mm] + s_3233[mm] -> s_3094[mm] + s_3218[mm] + s_3526[mm] YPL206C 0.00 1000.00 0.00 -r_3104 s_3448[ce] + s_3449[ce] -> s_0511[ce] + s_0793[ce] + s_3527[ce] YKR031C 0.00 1000.00 0.00 -r_3105 s_3449[ce] + s_3452[ce] -> s_0511[ce] + s_0793[ce] + s_3528[ce] YKR031C 0.00 1000.00 0.00 -r_3106 s_3449[ce] + s_3454[ce] -> s_0511[ce] + s_0793[ce] + s_3529[ce] YKR031C 0.00 1000.00 0.00 -r_3107 s_3449[ce] + s_3456[ce] -> s_0511[ce] + s_0793[ce] + s_3530[ce] YKR031C 0.00 1000.00 0.00 -r_3108 s_3449[ce] + s_3458[ce] -> s_0511[ce] + s_0793[ce] + s_3531[ce] YKR031C 0.00 1000.00 0.00 -r_3109 s_3449[ce] + s_3460[ce] -> s_0511[ce] + s_0793[ce] + s_3532[ce] YKR031C 0.00 1000.00 0.00 -r_3110 s_3449[ce] + s_3461[ce] -> s_0511[ce] + s_0793[ce] + s_3533[ce] YKR031C 0.00 1000.00 0.00 -r_3111 s_3449[ce] + s_3462[ce] -> s_0511[ce] + s_0793[ce] + s_3534[ce] YKR031C 0.00 1000.00 0.00 -r_3112 s_3449[ce] + s_3535[ce] -> s_3323[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3113 s_3449[ce] + s_3537[ce] -> s_3326[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3114 s_3449[ce] + s_3538[ce] -> s_3328[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3115 s_3449[ce] + s_3539[ce] -> s_3330[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3116 s_3449[ce] + s_3540[ce] -> s_3332[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3117 s_3449[ce] + s_3541[ce] -> s_3334[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3118 s_3449[ce] + s_3542[ce] -> s_3336[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3119 s_3449[ce] + s_3543[ce] -> s_3338[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3120 s_0803[c] + s_3544[c] -> s_1322[c] + s_3545[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3121 s_0803[c] + s_3546[c] -> s_1322[c] + s_3547[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3122 s_0803[c] + s_3548[c] -> s_1322[c] + s_3549[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3123 s_0803[c] + s_3550[c] -> s_1322[c] + s_3551[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3124 s_0803[c] + s_3552[c] -> s_1322[c] + s_3553[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3125 s_0803[c] + s_3554[c] -> s_1322[c] + s_3555[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3126 s_0803[c] + s_3556[c] -> s_1322[c] + s_3557[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3127 s_0803[c] + s_3558[c] -> s_1322[c] + s_3559[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3128 s_2808[erm] + s_3560[erm] -> s_2966[erm] + s_3118[erm] YKL212W 0.00 1000.00 0.00 -r_3129 s_2808[erm] + s_3561[erm] -> s_2966[erm] + s_3119[erm] YKL212W 0.00 1000.00 0.00 -r_3130 s_2808[erm] + s_3562[erm] -> s_2966[erm] + s_3120[erm] YKL212W 0.00 1000.00 0.00 -r_3131 s_2808[erm] + s_3563[erm] -> s_2966[erm] + s_3121[erm] YKL212W 0.00 1000.00 0.00 -r_3132 s_2808[erm] + s_3564[erm] -> s_2966[erm] + s_3122[erm] YKL212W 0.00 1000.00 0.00 -r_3133 s_2808[erm] + s_3565[erm] -> s_2966[erm] + s_3123[erm] YKL212W 0.00 1000.00 0.00 -r_3134 s_2808[erm] + s_3566[erm] -> s_2966[erm] + s_3124[erm] YKL212W 0.00 1000.00 0.00 -r_3135 s_2808[erm] + s_3567[erm] -> s_2966[erm] + s_3125[erm] YKL212W 0.00 1000.00 0.00 -r_3136 s_2994[gm] + s_3568[gm] -> s_2995[gm] + s_3358[gm] YKL212W 0.00 1000.00 0.00 -r_3137 s_2994[gm] + s_3569[gm] -> s_2995[gm] + s_3362[gm] YKL212W 0.00 1000.00 0.00 -r_3138 s_2994[gm] + s_3570[gm] -> s_2995[gm] + s_3364[gm] YKL212W 0.00 1000.00 0.00 -r_3139 s_2994[gm] + s_3571[gm] -> s_2995[gm] + s_3366[gm] YKL212W 0.00 1000.00 0.00 -r_3140 s_2994[gm] + s_3572[gm] -> s_2995[gm] + s_3368[gm] YKL212W 0.00 1000.00 0.00 -r_3141 s_2994[gm] + s_3573[gm] -> s_2995[gm] + s_3370[gm] YKL212W 0.00 1000.00 0.00 -r_3142 s_2994[gm] + s_3574[gm] -> s_2995[gm] + s_3372[gm] YKL212W 0.00 1000.00 0.00 -r_3143 s_2994[gm] + s_3575[gm] -> s_2995[gm] + s_3374[gm] YKL212W 0.00 1000.00 0.00 -r_3144 s_3325[ce] + s_3449[ce] -> s_3323[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3145 s_3327[ce] + s_3449[ce] -> s_3326[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3146 s_3329[ce] + s_3449[ce] -> s_3328[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3147 s_3331[ce] + s_3449[ce] -> s_3330[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3148 s_3333[ce] + s_3449[ce] -> s_3332[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3149 s_3335[ce] + s_3449[ce] -> s_3334[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3150 s_3337[ce] + s_3449[ce] -> s_3336[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3151 s_3339[ce] + s_3449[ce] -> s_3338[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3152 s_0803[c] + s_3576[c] -> s_1322[c] + s_3545[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3153 s_0803[c] + s_3577[c] -> s_1322[c] + s_3547[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3154 s_0803[c] + s_3578[c] -> s_1322[c] + s_3549[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3155 s_0803[c] + s_3579[c] -> s_1322[c] + s_3551[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3156 s_0803[c] + s_3580[c] -> s_1322[c] + s_3553[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3157 s_0803[c] + s_3581[c] -> s_1322[c] + s_3555[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3158 s_0803[c] + s_3582[c] -> s_1322[c] + s_3557[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3159 s_0803[c] + s_3583[c] -> s_1322[c] + s_3559[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3160 s_2808[erm] + s_3584[erm] -> s_2966[erm] + s_3118[erm] YKL212W 0.00 1000.00 0.00 -r_3161 s_2808[erm] + s_3585[erm] -> s_2966[erm] + s_3119[erm] YKL212W 0.00 1000.00 0.00 -r_3162 s_2808[erm] + s_3586[erm] -> s_2966[erm] + s_3120[erm] YKL212W 0.00 1000.00 0.00 -r_3163 s_2808[erm] + s_3587[erm] -> s_2966[erm] + s_3121[erm] YKL212W 0.00 1000.00 0.00 -r_3164 s_2808[erm] + s_3588[erm] -> s_2966[erm] + s_3122[erm] YKL212W 0.00 1000.00 0.00 -r_3165 s_2808[erm] + s_3589[erm] -> s_2966[erm] + s_3123[erm] YKL212W 0.00 1000.00 0.00 -r_3166 s_2808[erm] + s_3590[erm] -> s_2966[erm] + s_3124[erm] YKL212W 0.00 1000.00 0.00 -r_3167 s_2808[erm] + s_3591[erm] -> s_2966[erm] + s_3125[erm] YKL212W 0.00 1000.00 0.00 -r_3168 s_2994[gm] + s_3361[gm] -> s_2995[gm] + s_3358[gm] YKL212W 0.00 1000.00 0.00 -r_3169 s_2994[gm] + s_3363[gm] -> s_2995[gm] + s_3362[gm] YKL212W 0.00 1000.00 0.00 -r_3170 s_2994[gm] + s_3365[gm] -> s_2995[gm] + s_3364[gm] YKL212W 0.00 1000.00 0.00 -r_3171 s_2994[gm] + s_3367[gm] -> s_2995[gm] + s_3366[gm] YKL212W 0.00 1000.00 0.00 -r_3172 s_2994[gm] + s_3369[gm] -> s_2995[gm] + s_3368[gm] YKL212W 0.00 1000.00 0.00 -r_3173 s_2994[gm] + s_3371[gm] -> s_2995[gm] + s_3370[gm] YKL212W 0.00 1000.00 0.00 -r_3174 s_2994[gm] + s_3373[gm] -> s_2995[gm] + s_3372[gm] YKL212W 0.00 1000.00 0.00 -r_3175 s_2994[gm] + s_3375[gm] -> s_2995[gm] + s_3374[gm] YKL212W 0.00 1000.00 0.00 -r_3176 s_3449[ce] + s_3592[ce] -> s_3535[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3177 s_3449[ce] + s_3593[ce] -> s_3536[ce] + s_3537[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3178 s_3449[ce] + s_3594[ce] -> s_3536[ce] + s_3538[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3179 s_3449[ce] + s_3595[ce] -> s_3536[ce] + s_3539[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3180 s_3449[ce] + s_3596[ce] -> s_3536[ce] + s_3540[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3181 s_3449[ce] + s_3597[ce] -> s_3536[ce] + s_3541[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3182 s_3449[ce] + s_3598[ce] -> s_3536[ce] + s_3542[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3183 s_3449[ce] + s_3599[ce] -> s_3536[ce] + s_3543[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3184 s_0803[c] + s_3600[c] -> s_1322[c] + s_3544[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3185 s_0803[c] + s_3601[c] -> s_1322[c] + s_3546[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3186 s_0803[c] + s_3602[c] -> s_1322[c] + s_3548[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3187 s_0803[c] + s_3603[c] -> s_1322[c] + s_3550[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3188 s_0803[c] + s_3604[c] -> s_1322[c] + s_3552[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3189 s_0803[c] + s_3605[c] -> s_1322[c] + s_3554[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3190 s_0803[c] + s_3606[c] -> s_1322[c] + s_3556[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3191 s_0803[c] + s_3607[c] -> s_1322[c] + s_3558[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3192 s_3408[ce] + s_3449[ce] -> s_3325[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3193 s_3409[ce] + s_3449[ce] -> s_3327[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3194 s_3410[ce] + s_3449[ce] -> s_3329[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3195 s_3411[ce] + s_3449[ce] -> s_3331[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3196 s_3412[ce] + s_3449[ce] -> s_3333[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3197 s_3413[ce] + s_3449[ce] -> s_3335[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3198 s_3414[ce] + s_3449[ce] -> s_3337[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3199 s_3415[ce] + s_3449[ce] -> s_3339[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3200 s_0803[c] + s_3496[c] -> s_1322[c] + s_3576[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3201 s_0803[c] + s_3499[c] -> s_1322[c] + s_3577[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3202 s_0803[c] + s_3501[c] -> s_1322[c] + s_3578[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3203 s_0803[c] + s_3503[c] -> s_1322[c] + s_3579[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3204 s_0803[c] + s_3505[c] -> s_1322[c] + s_3580[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3205 s_0803[c] + s_3507[c] -> s_1322[c] + s_3581[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3206 s_0803[c] + s_3509[c] -> s_1322[c] + s_3582[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3207 s_0803[c] + s_3511[c] -> s_1322[c] + s_3583[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 -r_3208 s_2808[erm] + s_3608[erm] -> s_2966[erm] + s_3584[erm] YOL065C 0.00 1000.00 0.00 -r_3209 s_2808[erm] + s_3609[erm] -> s_2966[erm] + s_3585[erm] YOL065C 0.00 1000.00 0.00 -r_3210 s_2808[erm] + s_3610[erm] -> s_2966[erm] + s_3586[erm] YOL065C 0.00 1000.00 0.00 -r_3211 s_2808[erm] + s_3611[erm] -> s_2966[erm] + s_3587[erm] YOL065C 0.00 1000.00 0.00 -r_3212 s_2808[erm] + s_3612[erm] -> s_2966[erm] + s_3588[erm] YOL065C 0.00 1000.00 0.00 -r_3213 s_2808[erm] + s_3613[erm] -> s_2966[erm] + s_3589[erm] YOL065C 0.00 1000.00 0.00 -r_3214 s_2808[erm] + s_3614[erm] -> s_2966[erm] + s_3590[erm] YOL065C 0.00 1000.00 0.00 -r_3215 s_2808[erm] + s_3615[erm] -> s_2966[erm] + s_3591[erm] YOL065C 0.00 1000.00 0.00 -r_3216 s_2976[vm] + s_3416[vm] -> s_2977[vm] + s_3392[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 -r_3217 s_2976[vm] + s_3417[vm] -> s_2977[vm] + s_3393[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 -r_3218 s_2976[vm] + s_3418[vm] -> s_2977[vm] + s_3394[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 -r_3219 s_2976[vm] + s_3419[vm] -> s_2977[vm] + s_3395[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 -r_3220 s_2976[vm] + s_3420[vm] -> s_2977[vm] + s_3396[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 -r_3221 s_2976[vm] + s_3421[vm] -> s_2977[vm] + s_3397[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 -r_3222 s_2976[vm] + s_3422[vm] -> s_2977[vm] + s_3398[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 -r_3223 s_2976[vm] + s_3423[vm] -> s_2977[vm] + s_3399[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 -r_3224 s_2976[vm] + s_3616[vm] -> s_2975[vm] + s_2977[vm] + s_3164[vm] YDR284C 0.00 1000.00 0.00 -r_3225 s_2976[vm] + s_3617[vm] -> s_2977[vm] + s_2981[vm] + s_3164[vm] YDR284C 0.00 1000.00 0.00 -r_3226 s_2976[vm] + s_3618[vm] -> s_2977[vm] + s_2985[vm] + s_3164[vm] YDR284C 0.00 1000.00 0.00 -r_3227 s_2976[vm] + s_3619[vm] -> s_2977[vm] + s_2989[vm] + s_3164[vm] YDR284C 0.00 1000.00 0.00 -r_3228 s_2976[vm] + s_3620[vm] -> s_2977[vm] + s_2979[vm] + s_3164[vm] YDR284C 0.00 1000.00 0.00 -r_3229 s_2976[vm] + s_3621[vm] -> s_2977[vm] + s_2983[vm] + s_3164[vm] YDR284C 0.00 1000.00 0.00 -r_3230 s_2976[vm] + s_3622[vm] -> s_2977[vm] + s_2987[vm] + s_3164[vm] YDR284C 0.00 1000.00 0.00 -r_3231 s_2976[vm] + s_3623[vm] -> s_2977[vm] + s_2991[vm] + s_3164[vm] YDR284C 0.00 1000.00 0.00 -r_3232 s_2994[gm] + s_3624[gm] -> s_2993[gm] + s_2995[gm] + s_3146[gm] YDR503C 0.00 1000.00 0.00 -r_3233 s_2994[gm] + s_3625[gm] -> s_2995[gm] + s_2999[gm] + s_3146[gm] YDR503C 0.00 1000.00 0.00 -r_3234 s_2994[gm] + s_3626[gm] -> s_2995[gm] + s_3003[gm] + s_3146[gm] YDR503C 0.00 1000.00 0.00 -r_3235 s_2994[gm] + s_3627[gm] -> s_2995[gm] + s_3007[gm] + s_3146[gm] YDR503C 0.00 1000.00 0.00 -r_3236 s_2994[gm] + s_3628[gm] -> s_2995[gm] + s_2997[gm] + s_3146[gm] YDR503C 0.00 1000.00 0.00 -r_3237 s_2994[gm] + s_3629[gm] -> s_2995[gm] + s_3001[gm] + s_3146[gm] YDR503C 0.00 1000.00 0.00 -r_3238 s_2994[gm] + s_3630[gm] -> s_2995[gm] + s_3005[gm] + s_3146[gm] YDR503C 0.00 1000.00 0.00 -r_3239 s_2994[gm] + s_3631[gm] -> s_2995[gm] + s_3009[gm] + s_3146[gm] YDR503C 0.00 1000.00 0.00 -r_3240 s_0803[c] + s_3632[c] -> s_1322[c] + s_3633[c] YER037W 0.00 1000.00 0.00 -r_3241 s_0803[c] + s_3634[c] -> s_1322[c] + s_3635[c] YER037W 0.00 1000.00 0.00 -r_3242 s_0803[c] + s_3636[c] -> s_1322[c] + s_3637[c] YER037W 0.00 1000.00 0.00 -r_3243 s_0803[c] + s_3638[c] -> s_1322[c] + s_3639[c] YER037W 0.00 1000.00 0.00 -r_3244 s_2976[vm] + s_3640[vm] -> s_2977[vm] + s_3641[vm] YDR284C 0.00 1000.00 0.00 -r_3245 s_2976[vm] + s_3642[vm] -> s_2977[vm] + s_3643[vm] YDR284C 0.00 1000.00 0.00 -r_3246 s_2976[vm] + s_3644[vm] -> s_2977[vm] + s_3645[vm] YDR284C 0.00 1000.00 0.00 -r_3247 s_2976[vm] + s_3646[vm] -> s_2977[vm] + s_3647[vm] YDR284C 0.00 1000.00 0.00 -r_3248 s_2994[gm] + s_3648[gm] -> s_2995[gm] + s_3649[gm] YDR503C 0.00 1000.00 0.00 -r_3249 s_2994[gm] + s_3650[gm] -> s_2995[gm] + s_3651[gm] YDR503C 0.00 1000.00 0.00 -r_3250 s_2994[gm] + s_3652[gm] -> s_2995[gm] + s_3653[gm] YDR503C 0.00 1000.00 0.00 -r_3251 s_2994[gm] + s_3654[gm] -> s_2995[gm] + s_3655[gm] YDR503C 0.00 1000.00 0.00 +r_3078 s_3449[ce] + s_3491[ce] -> 2 s_0793[ce] + s_3463[ce] + s_3495[ce] YOL011W 0.00 1000.00 0.00 +r_3079 s_3449[ce] + s_3492[ce] -> 2 s_0793[ce] + s_3451[ce] + s_3495[ce] YOL011W 0.00 1000.00 0.00 +r_3080 s_3449[ce] + s_3493[ce] -> 2 s_0793[ce] + s_3464[ce] + s_3495[ce] YOL011W 0.00 1000.00 0.00 +r_3081 s_3449[ce] + s_3494[ce] -> 2 s_0793[ce] + s_3459[ce] + s_3495[ce] YOL011W 0.00 1000.00 0.00 +r_3082 s_0803[c] + s_3496[c] -> 6 s_0794[c] + s_3497[c] + s_3498[c] YPL268W 0.00 1000.00 0.00 +r_3083 s_0803[c] + s_3499[c] -> 6 s_0794[c] + s_3498[c] + s_3500[c] YPL268W 0.00 1000.00 0.00 +r_3084 s_0803[c] + s_3501[c] -> 6 s_0794[c] + s_3498[c] + s_3502[c] YPL268W 0.00 1000.00 0.00 +r_3085 s_0803[c] + s_3503[c] -> 6 s_0794[c] + s_3498[c] + s_3504[c] YPL268W 0.00 1000.00 0.00 +r_3086 s_0803[c] + s_3505[c] -> 6 s_0794[c] + s_3498[c] + s_3506[c] YPL268W 0.00 1000.00 0.00 +r_3087 s_0803[c] + s_3507[c] -> 6 s_0794[c] + s_3498[c] + s_3508[c] YPL268W 0.00 1000.00 0.00 +r_3088 s_0803[c] + s_3509[c] -> 6 s_0794[c] + s_3498[c] + s_3510[c] YPL268W 0.00 1000.00 0.00 +r_3089 s_0803[c] + s_3511[c] -> 6 s_0794[c] + s_3498[c] + s_3512[c] YPL268W 0.00 1000.00 0.00 +r_3090 s_0808[n] + s_3400[n] -> s_0125[n] + 6 s_0800[n] + s_3513[n] YPL268W 0.00 1000.00 0.00 +r_3091 s_0808[n] + s_3401[n] -> s_0125[n] + 6 s_0800[n] + s_3514[n] YPL268W 0.00 1000.00 0.00 +r_3092 s_0808[n] + s_3402[n] -> s_0125[n] + 6 s_0800[n] + s_3515[n] YPL268W 0.00 1000.00 0.00 +r_3093 s_0808[n] + s_3403[n] -> s_0125[n] + 6 s_0800[n] + s_3516[n] YPL268W 0.00 1000.00 0.00 +r_3094 s_0808[n] + s_3404[n] -> s_0125[n] + 6 s_0800[n] + s_3517[n] YPL268W 0.00 1000.00 0.00 +r_3095 s_0808[n] + s_3405[n] -> s_0125[n] + 6 s_0800[n] + s_3518[n] YPL268W 0.00 1000.00 0.00 +r_3096 s_0808[n] + s_3406[n] -> s_0125[n] + 6 s_0800[n] + s_3519[n] YPL268W 0.00 1000.00 0.00 +r_3097 s_0808[n] + s_3407[n] -> s_0125[n] + 6 s_0800[n] + s_3520[n] YPL268W 0.00 1000.00 0.00 +r_3098 s_3226[mm] + s_3227[mm] -> 2 s_3094[mm] + s_3218[mm] + s_3521[mm] YPL206C 0.00 1000.00 0.00 +r_3099 s_3226[mm] + s_3229[mm] -> 2 s_3094[mm] + s_3218[mm] + s_3522[mm] YPL206C 0.00 1000.00 0.00 +r_3100 s_3226[mm] + s_3230[mm] -> 2 s_3094[mm] + s_3218[mm] + s_3523[mm] YPL206C 0.00 1000.00 0.00 +r_3101 s_3226[mm] + s_3231[mm] -> 2 s_3094[mm] + s_3218[mm] + s_3524[mm] YPL206C 0.00 1000.00 0.00 +r_3102 s_3226[mm] + s_3232[mm] -> 2 s_3094[mm] + s_3218[mm] + s_3525[mm] YPL206C 0.00 1000.00 0.00 +r_3103 s_3226[mm] + s_3233[mm] -> 2 s_3094[mm] + s_3218[mm] + s_3526[mm] YPL206C 0.00 1000.00 0.00 +r_3104 s_0793[ce] + s_3448[ce] + s_3449[ce] -> s_0511[ce] + s_3527[ce] YKR031C 0.00 1000.00 0.00 +r_3105 s_0793[ce] + s_3449[ce] + s_3452[ce] -> s_0511[ce] + s_3528[ce] YKR031C 0.00 1000.00 0.00 +r_3106 s_0793[ce] + s_3449[ce] + s_3454[ce] -> s_0511[ce] + s_3529[ce] YKR031C 0.00 1000.00 0.00 +r_3107 s_0793[ce] + s_3449[ce] + s_3456[ce] -> s_0511[ce] + s_3530[ce] YKR031C 0.00 1000.00 0.00 +r_3108 s_0793[ce] + s_3449[ce] + s_3458[ce] -> s_0511[ce] + s_3531[ce] YKR031C 0.00 1000.00 0.00 +r_3109 s_0793[ce] + s_3449[ce] + s_3460[ce] -> s_0511[ce] + s_3532[ce] YKR031C 0.00 1000.00 0.00 +r_3110 s_0793[ce] + s_3449[ce] + s_3461[ce] -> s_0511[ce] + s_3533[ce] YKR031C 0.00 1000.00 0.00 +r_3111 s_0793[ce] + s_3449[ce] + s_3462[ce] -> s_0511[ce] + s_3534[ce] YKR031C 0.00 1000.00 0.00 +r_3112 s_3449[ce] + s_3535[ce] -> 2 s_0793[ce] + s_3323[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3113 s_3449[ce] + s_3537[ce] -> 2 s_0793[ce] + s_3326[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3114 s_3449[ce] + s_3538[ce] -> 2 s_0793[ce] + s_3328[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3115 s_3449[ce] + s_3539[ce] -> 2 s_0793[ce] + s_3330[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3116 s_3449[ce] + s_3540[ce] -> 2 s_0793[ce] + s_3332[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3117 s_3449[ce] + s_3541[ce] -> 2 s_0793[ce] + s_3334[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3118 s_3449[ce] + s_3542[ce] -> 2 s_0793[ce] + s_3336[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3119 s_3449[ce] + s_3543[ce] -> 2 s_0793[ce] + s_3338[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3120 s_0803[c] + s_3544[c] -> 2 s_0794[c] + s_1322[c] + s_3545[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3121 s_0803[c] + s_3546[c] -> 2 s_0794[c] + s_1322[c] + s_3547[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3122 s_0803[c] + s_3548[c] -> 2 s_0794[c] + s_1322[c] + s_3549[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3123 s_0803[c] + s_3550[c] -> 2 s_0794[c] + s_1322[c] + s_3551[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3124 s_0803[c] + s_3552[c] -> 2 s_0794[c] + s_1322[c] + s_3553[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3125 s_0803[c] + s_3554[c] -> 2 s_0794[c] + s_1322[c] + s_3555[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3126 s_0803[c] + s_3556[c] -> 2 s_0794[c] + s_1322[c] + s_3557[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3127 s_0803[c] + s_3558[c] -> 2 s_0794[c] + s_1322[c] + s_3559[c] ( YJR110W or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3128 s_2808[erm] + s_3560[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3118[erm] YKL212W 0.00 1000.00 0.00 +r_3129 s_2808[erm] + s_3561[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3119[erm] YKL212W 0.00 1000.00 0.00 +r_3130 s_2808[erm] + s_3562[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3120[erm] YKL212W 0.00 1000.00 0.00 +r_3131 s_2808[erm] + s_3563[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3121[erm] YKL212W 0.00 1000.00 0.00 +r_3132 s_2808[erm] + s_3564[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3122[erm] YKL212W 0.00 1000.00 0.00 +r_3133 s_2808[erm] + s_3565[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3123[erm] YKL212W 0.00 1000.00 0.00 +r_3134 s_2808[erm] + s_3566[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3124[erm] YKL212W 0.00 1000.00 0.00 +r_3135 s_2808[erm] + s_3567[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3125[erm] YKL212W 0.00 1000.00 0.00 +r_3136 s_2994[gm] + s_3568[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3358[gm] YKL212W 0.00 1000.00 0.00 +r_3137 s_2994[gm] + s_3569[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3362[gm] YKL212W 0.00 1000.00 0.00 +r_3138 s_2994[gm] + s_3570[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3364[gm] YKL212W 0.00 1000.00 0.00 +r_3139 s_2994[gm] + s_3571[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3366[gm] YKL212W 0.00 1000.00 0.00 +r_3140 s_2994[gm] + s_3572[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3368[gm] YKL212W 0.00 1000.00 0.00 +r_3141 s_2994[gm] + s_3573[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3370[gm] YKL212W 0.00 1000.00 0.00 +r_3142 s_2994[gm] + s_3574[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3372[gm] YKL212W 0.00 1000.00 0.00 +r_3143 s_2994[gm] + s_3575[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3374[gm] YKL212W 0.00 1000.00 0.00 +r_3144 s_3325[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3323[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3145 s_3327[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3326[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3146 s_3329[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3328[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3147 s_3331[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3330[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3148 s_3333[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3332[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3149 s_3335[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3334[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3150 s_3337[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3336[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3151 s_3339[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3338[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3152 s_0803[c] + s_3576[c] -> 2 s_0794[c] + s_1322[c] + s_3545[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3153 s_0803[c] + s_3577[c] -> 2 s_0794[c] + s_1322[c] + s_3547[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3154 s_0803[c] + s_3578[c] -> 2 s_0794[c] + s_1322[c] + s_3549[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3155 s_0803[c] + s_3579[c] -> 2 s_0794[c] + s_1322[c] + s_3551[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3156 s_0803[c] + s_3580[c] -> 2 s_0794[c] + s_1322[c] + s_3553[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3157 s_0803[c] + s_3581[c] -> 2 s_0794[c] + s_1322[c] + s_3555[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3158 s_0803[c] + s_3582[c] -> 2 s_0794[c] + s_1322[c] + s_3557[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3159 s_0803[c] + s_3583[c] -> 2 s_0794[c] + s_1322[c] + s_3559[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3160 s_2808[erm] + s_3584[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3118[erm] YKL212W 0.00 1000.00 0.00 +r_3161 s_2808[erm] + s_3585[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3119[erm] YKL212W 0.00 1000.00 0.00 +r_3162 s_2808[erm] + s_3586[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3120[erm] YKL212W 0.00 1000.00 0.00 +r_3163 s_2808[erm] + s_3587[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3121[erm] YKL212W 0.00 1000.00 0.00 +r_3164 s_2808[erm] + s_3588[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3122[erm] YKL212W 0.00 1000.00 0.00 +r_3165 s_2808[erm] + s_3589[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3123[erm] YKL212W 0.00 1000.00 0.00 +r_3166 s_2808[erm] + s_3590[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3124[erm] YKL212W 0.00 1000.00 0.00 +r_3167 s_2808[erm] + s_3591[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3125[erm] YKL212W 0.00 1000.00 0.00 +r_3168 s_2994[gm] + s_3361[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3358[gm] YKL212W 0.00 1000.00 0.00 +r_3169 s_2994[gm] + s_3363[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3362[gm] YKL212W 0.00 1000.00 0.00 +r_3170 s_2994[gm] + s_3365[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3364[gm] YKL212W 0.00 1000.00 0.00 +r_3171 s_2994[gm] + s_3367[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3366[gm] YKL212W 0.00 1000.00 0.00 +r_3172 s_2994[gm] + s_3369[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3368[gm] YKL212W 0.00 1000.00 0.00 +r_3173 s_2994[gm] + s_3371[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3370[gm] YKL212W 0.00 1000.00 0.00 +r_3174 s_2994[gm] + s_3373[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3372[gm] YKL212W 0.00 1000.00 0.00 +r_3175 s_2994[gm] + s_3375[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3374[gm] YKL212W 0.00 1000.00 0.00 +r_3176 s_3449[ce] + s_3592[ce] -> 2 s_0793[ce] + s_3535[ce] + s_3536[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3177 s_3449[ce] + s_3593[ce] -> 2 s_0793[ce] + s_3536[ce] + s_3537[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3178 s_3449[ce] + s_3594[ce] -> 2 s_0793[ce] + s_3536[ce] + s_3538[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3179 s_3449[ce] + s_3595[ce] -> 2 s_0793[ce] + s_3536[ce] + s_3539[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3180 s_3449[ce] + s_3596[ce] -> 2 s_0793[ce] + s_3536[ce] + s_3540[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3181 s_3449[ce] + s_3597[ce] -> 2 s_0793[ce] + s_3536[ce] + s_3541[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3182 s_3449[ce] + s_3598[ce] -> 2 s_0793[ce] + s_3536[ce] + s_3542[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3183 s_3449[ce] + s_3599[ce] -> 2 s_0793[ce] + s_3536[ce] + s_3543[ce] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3184 s_0803[c] + s_3600[c] -> 2 s_0794[c] + s_1322[c] + s_3544[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3185 s_0803[c] + s_3601[c] -> 2 s_0794[c] + s_1322[c] + s_3546[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3186 s_0803[c] + s_3602[c] -> 2 s_0794[c] + s_1322[c] + s_3548[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3187 s_0803[c] + s_3603[c] -> 2 s_0794[c] + s_1322[c] + s_3550[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3188 s_0803[c] + s_3604[c] -> 2 s_0794[c] + s_1322[c] + s_3552[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3189 s_0803[c] + s_3605[c] -> 2 s_0794[c] + s_1322[c] + s_3554[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3190 s_0803[c] + s_3606[c] -> 2 s_0794[c] + s_1322[c] + s_3556[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3191 s_0803[c] + s_3607[c] -> 2 s_0794[c] + s_1322[c] + s_3558[c] ( YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3192 s_3408[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3325[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3193 s_3409[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3327[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3194 s_3410[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3329[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3195 s_3411[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3331[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3196 s_3412[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3333[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3197 s_3413[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3335[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3198 s_3414[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3337[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3199 s_3415[ce] + s_3449[ce] -> 2 s_0793[ce] + s_3339[ce] + s_3536[ce] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3200 s_0803[c] + s_3496[c] -> 2 s_0794[c] + s_1322[c] + s_3576[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3201 s_0803[c] + s_3499[c] -> 2 s_0794[c] + s_1322[c] + s_3577[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3202 s_0803[c] + s_3501[c] -> 2 s_0794[c] + s_1322[c] + s_3578[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3203 s_0803[c] + s_3503[c] -> 2 s_0794[c] + s_1322[c] + s_3579[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3204 s_0803[c] + s_3505[c] -> 2 s_0794[c] + s_1322[c] + s_3580[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3205 s_0803[c] + s_3507[c] -> 2 s_0794[c] + s_1322[c] + s_3581[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3206 s_0803[c] + s_3509[c] -> 2 s_0794[c] + s_1322[c] + s_3582[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3207 s_0803[c] + s_3511[c] -> 2 s_0794[c] + s_1322[c] + s_3583[c] ( YIL002C or YNL106C or YOR109W ) 0.00 1000.00 0.00 +r_3208 s_2808[erm] + s_3608[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3584[erm] YOL065C 0.00 1000.00 0.00 +r_3209 s_2808[erm] + s_3609[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3585[erm] YOL065C 0.00 1000.00 0.00 +r_3210 s_2808[erm] + s_3610[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3586[erm] YOL065C 0.00 1000.00 0.00 +r_3211 s_2808[erm] + s_3611[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3587[erm] YOL065C 0.00 1000.00 0.00 +r_3212 s_2808[erm] + s_3612[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3588[erm] YOL065C 0.00 1000.00 0.00 +r_3213 s_2808[erm] + s_3613[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3589[erm] YOL065C 0.00 1000.00 0.00 +r_3214 s_2808[erm] + s_3614[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3590[erm] YOL065C 0.00 1000.00 0.00 +r_3215 s_2808[erm] + s_3615[erm] -> 2 s_2783[erm] + s_2966[erm] + s_3591[erm] YOL065C 0.00 1000.00 0.00 +r_3216 s_2976[vm] + s_3416[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3392[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 +r_3217 s_2976[vm] + s_3417[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3393[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 +r_3218 s_2976[vm] + s_3418[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3394[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 +r_3219 s_2976[vm] + s_3419[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3395[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 +r_3220 s_2976[vm] + s_3420[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3396[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 +r_3221 s_2976[vm] + s_3421[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3397[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 +r_3222 s_2976[vm] + s_3422[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3398[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 +r_3223 s_2976[vm] + s_3423[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3399[vm] ( YLR386W and YNL325C ) 0.00 1000.00 0.00 +r_3224 s_2976[vm] + s_3616[vm] -> s_2975[vm] + s_2977[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_3225 s_2976[vm] + s_3617[vm] -> s_2977[vm] + s_2981[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_3226 s_2976[vm] + s_3618[vm] -> s_2977[vm] + s_2985[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_3227 s_2976[vm] + s_3619[vm] -> s_2977[vm] + s_2989[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_3228 s_2976[vm] + s_3620[vm] -> s_2977[vm] + s_2979[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_3229 s_2976[vm] + s_3621[vm] -> s_2977[vm] + s_2983[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_3230 s_2976[vm] + s_3622[vm] -> s_2977[vm] + s_2987[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_3231 s_2976[vm] + s_3623[vm] -> s_2977[vm] + s_2991[vm] + 2 s_3164[vm] YDR284C 0.00 1000.00 0.00 +r_3232 s_2994[gm] + s_3624[gm] -> s_2993[gm] + s_2995[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_3233 s_2994[gm] + s_3625[gm] -> s_2995[gm] + s_2999[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_3234 s_2994[gm] + s_3626[gm] -> s_2995[gm] + s_3003[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_3235 s_2994[gm] + s_3627[gm] -> s_2995[gm] + s_3007[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_3236 s_2994[gm] + s_3628[gm] -> s_2995[gm] + s_2997[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_3237 s_2994[gm] + s_3629[gm] -> s_2995[gm] + s_3001[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_3238 s_2994[gm] + s_3630[gm] -> s_2995[gm] + s_3005[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_3239 s_2994[gm] + s_3631[gm] -> s_2995[gm] + s_3009[gm] + 2 s_3146[gm] YDR503C 0.00 1000.00 0.00 +r_3240 s_0803[c] + s_3632[c] -> 2 s_0794[c] + s_1322[c] + s_3633[c] YER037W 0.00 1000.00 0.00 +r_3241 s_0803[c] + s_3634[c] -> 2 s_0794[c] + s_1322[c] + s_3635[c] YER037W 0.00 1000.00 0.00 +r_3242 s_0803[c] + s_3636[c] -> 2 s_0794[c] + s_1322[c] + s_3637[c] YER037W 0.00 1000.00 0.00 +r_3243 s_0803[c] + s_3638[c] -> 2 s_0794[c] + s_1322[c] + s_3639[c] YER037W 0.00 1000.00 0.00 +r_3244 s_2976[vm] + s_3640[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3641[vm] YDR284C 0.00 1000.00 0.00 +r_3245 s_2976[vm] + s_3642[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3643[vm] YDR284C 0.00 1000.00 0.00 +r_3246 s_2976[vm] + s_3644[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3645[vm] YDR284C 0.00 1000.00 0.00 +r_3247 s_2976[vm] + s_3646[vm] -> s_2977[vm] + 2 s_3164[vm] + s_3647[vm] YDR284C 0.00 1000.00 0.00 +r_3248 s_2994[gm] + s_3648[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3649[gm] YDR503C 0.00 1000.00 0.00 +r_3249 s_2994[gm] + s_3650[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3651[gm] YDR503C 0.00 1000.00 0.00 +r_3250 s_2994[gm] + s_3652[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3653[gm] YDR503C 0.00 1000.00 0.00 +r_3251 s_2994[gm] + s_3654[gm] -> s_2995[gm] + 2 s_3146[gm] + s_3655[gm] YDR503C 0.00 1000.00 0.00 r_3252 s_3656[lp] + s_3657[lp] -> s_0669[lp] + s_0798[lp] + s_2848[lp] ( YKL140W or YLL012W ) 0.00 1000.00 0.00 r_3253 s_3657[lp] + s_3658[lp] -> s_0669[lp] + s_0798[lp] + s_2852[lp] ( YKL140W or YLL012W ) 0.00 1000.00 0.00 r_3254 s_3657[lp] + s_3659[lp] -> s_0798[lp] + s_2848[lp] + s_3660[lp] YLL012W 0.00 1000.00 0.00 @@ -2005,7 +2005,7 @@ r_3329 s_3657[lp] + s_3688[lp] -> s_0798[lp] + s_2852[lp] + s_3687[lp] YKR089C r_3330 s_3657[lp] + s_3690[lp] -> s_0798[lp] + s_2852[lp] + s_3689[lp] YKR089C 0.00 1000.00 0.00 r_3331 s_3657[lp] + s_3692[lp] -> s_0798[lp] + s_2852[lp] + s_3691[lp] YKR089C 0.00 1000.00 0.00 r_4039 s_0365[m] + s_1464[m] <=> s_0376[m] + s_1460[m] YBL015W -1000.00 1000.00 0.00 -r_4042 s_3715[e] -> s_0554[e] + s_3716[e] YIL020C 0.00 1000.00 0.00 +r_4042 s_0805[e] + s_3715[e] -> s_0554[e] + s_3716[e] YIL020C 0.00 1000.00 0.00 r_4045 s_0803[c] + s_1556[c] -> s_0575[c] + s_1550[c] YDR400W 0.00 1000.00 0.00 r_0964 s_0434[c] + s_0750[c] + s_0803[c] -> s_0394[c] + s_0753[v] + s_0794[c] + s_1322[c] YDR135C 0.00 1000.00 0.00 r_1028 s_0434[c] + s_0803[c] + s_1473[c] -> s_0394[c] + s_0794[c] + s_1322[c] + s_1474[v] YLL048C 0.00 1000.00 0.00 @@ -2489,7 +2489,7 @@ r_1598 s_0235[e] -> 0.00 1000.00 0.00 r_1599 s_0234[c] <=> s_0235[e] -1000.00 1000.00 0.00 r_1600 s_0234[c] <=> s_0236[m] -1000.00 1000.00 0.00 r_1601 s_0215[c] <=> s_0216[m] -1000.00 1000.00 0.00 -r_1603 s_0300[c] + 2 s_0794[c] -> s_0270[c] + s_0775[c] + s_1322[c] YFL058W 0.00 1000.00 0.00 +r_1603 s_0300[c] -> s_0270[c] + s_0775[c] + s_0794[c] + s_1322[c] YFL058W 0.00 1000.00 0.00 r_1604 s_0272[e] -> 0.00 1000.00 0.00 r_1605 s_0271[c] <=> s_0272[e] -1000.00 1000.00 0.00 r_1606 s_0271[c] <=> s_0273[m] -1000.00 1000.00 0.00 @@ -2627,7 +2627,6 @@ r_1754 s_0662[c] <=> s_0663[er] -1000.00 1000.00 0.00 r_1757 s_0668[e] -> 0.00 1000.00 0.00 r_1758 s_0667[er] <=> s_0666[c] -1000.00 1000.00 0.00 r_1759 s_0666[c] <=> s_0669[lp] -1000.00 1000.00 0.00 -r_1760 s_0666[c] <=> s_0665[ce] ( YIL013C or YOR011W ) -1000.00 1000.00 0.00 r_1761 s_0681[e] -> 0.00 1000.00 0.00 r_1762 s_0680[c] <=> s_0681[e] -1000.00 1000.00 0.00 r_1763 s_0680[c] <=> s_0682[m] -1000.00 1000.00 0.00 @@ -2933,22 +2932,22 @@ r_2816 s_3301[mm] + s_3320[mm] -> s_3300[mm] + s_3321[mm] 0.00 1000.00 0. r_2817 s_3301[mm] + s_3322[mm] -> s_3306[mm] + s_3321[mm] 0.00 1000.00 0.00 r_2818 s_3303[mm] + s_3320[mm] -> s_3302[mm] + s_3321[mm] 0.00 1000.00 0.00 r_2819 s_3303[mm] + s_3322[mm] -> s_3307[mm] + s_3321[mm] 0.00 1000.00 0.00 -r_3332 s_2993[gm] + s_3359[gm] <=> s_3360[gm] + s_3624[gm] -1000.00 1000.00 0.00 -r_3333 s_2999[gm] + s_3359[gm] <=> s_3360[gm] + s_3625[gm] -1000.00 1000.00 0.00 -r_3334 s_3003[gm] + s_3359[gm] <=> s_3360[gm] + s_3626[gm] -1000.00 1000.00 0.00 -r_3335 s_3007[gm] + s_3359[gm] <=> s_3360[gm] + s_3627[gm] -1000.00 1000.00 0.00 -r_3336 s_2997[gm] + s_3359[gm] <=> s_3360[gm] + s_3628[gm] -1000.00 1000.00 0.00 -r_3337 s_3001[gm] + s_3359[gm] <=> s_3360[gm] + s_3629[gm] -1000.00 1000.00 0.00 -r_3338 s_3005[gm] + s_3359[gm] <=> s_3360[gm] + s_3630[gm] -1000.00 1000.00 0.00 -r_3339 s_3009[gm] + s_3359[gm] <=> s_3360[gm] + s_3631[gm] -1000.00 1000.00 0.00 -r_3340 s_2975[vm] + s_3341[vm] <=> s_3342[vm] + s_3616[vm] -1000.00 1000.00 0.00 -r_3341 s_2981[vm] + s_3341[vm] <=> s_3342[vm] + s_3617[vm] -1000.00 1000.00 0.00 -r_3342 s_2985[vm] + s_3341[vm] <=> s_3342[vm] + s_3618[vm] -1000.00 1000.00 0.00 -r_3343 s_2989[vm] + s_3341[vm] <=> s_3342[vm] + s_3619[vm] -1000.00 1000.00 0.00 -r_3344 s_2979[vm] + s_3341[vm] <=> s_3342[vm] + s_3620[vm] -1000.00 1000.00 0.00 -r_3345 s_2983[vm] + s_3341[vm] <=> s_3342[vm] + s_3621[vm] -1000.00 1000.00 0.00 -r_3346 s_2987[vm] + s_3341[vm] <=> s_3342[vm] + s_3622[vm] -1000.00 1000.00 0.00 -r_3347 s_2991[vm] + s_3341[vm] <=> s_3342[vm] + s_3623[vm] -1000.00 1000.00 0.00 +r_3332 s_2993[gm] + s_3146[gm] + s_3359[gm] <=> s_3360[gm] + s_3624[gm] -1000.00 1000.00 0.00 +r_3333 s_2999[gm] + s_3146[gm] + s_3359[gm] <=> s_3360[gm] + s_3625[gm] -1000.00 1000.00 0.00 +r_3334 s_3003[gm] + s_3146[gm] + s_3359[gm] <=> s_3360[gm] + s_3626[gm] -1000.00 1000.00 0.00 +r_3335 s_3007[gm] + s_3146[gm] + s_3359[gm] <=> s_3360[gm] + s_3627[gm] -1000.00 1000.00 0.00 +r_3336 s_2997[gm] + s_3146[gm] + s_3359[gm] <=> s_3360[gm] + s_3628[gm] -1000.00 1000.00 0.00 +r_3337 s_3001[gm] + s_3146[gm] + s_3359[gm] <=> s_3360[gm] + s_3629[gm] -1000.00 1000.00 0.00 +r_3338 s_3005[gm] + s_3146[gm] + s_3359[gm] <=> s_3360[gm] + s_3630[gm] -1000.00 1000.00 0.00 +r_3339 s_3009[gm] + s_3146[gm] + s_3359[gm] <=> s_3360[gm] + s_3631[gm] -1000.00 1000.00 0.00 +r_3340 s_2975[vm] + s_3164[vm] + s_3341[vm] <=> s_3342[vm] + s_3616[vm] -1000.00 1000.00 0.00 +r_3341 s_2981[vm] + s_3164[vm] + s_3341[vm] <=> s_3342[vm] + s_3617[vm] -1000.00 1000.00 0.00 +r_3342 s_2985[vm] + s_3164[vm] + s_3341[vm] <=> s_3342[vm] + s_3618[vm] -1000.00 1000.00 0.00 +r_3343 s_2989[vm] + s_3164[vm] + s_3341[vm] <=> s_3342[vm] + s_3619[vm] -1000.00 1000.00 0.00 +r_3344 s_2979[vm] + s_3164[vm] + s_3341[vm] <=> s_3342[vm] + s_3620[vm] -1000.00 1000.00 0.00 +r_3345 s_2983[vm] + s_3164[vm] + s_3341[vm] <=> s_3342[vm] + s_3621[vm] -1000.00 1000.00 0.00 +r_3346 s_2987[vm] + s_3164[vm] + s_3341[vm] <=> s_3342[vm] + s_3622[vm] -1000.00 1000.00 0.00 +r_3347 s_2991[vm] + s_3164[vm] + s_3341[vm] <=> s_3342[vm] + s_3623[vm] -1000.00 1000.00 0.00 r_3508 s_1065[c] <=> s_2832[erm] -1000.00 1000.00 0.00 r_3509 s_1161[c] <=> s_2835[erm] -1000.00 1000.00 0.00 r_3510 s_1286[c] <=> s_2836[erm] -1000.00 1000.00 0.00 @@ -3522,7 +3521,7 @@ r_4151 s_3319[mm] -> 1.42997 s_3738[mm] + 0.254413 s_3741[c] + 0.8474 s_3743[c] r_4152 s_3748[m] <=> s_0712[m] + s_3749[m] ( YAL039C or YKL087C ) -1000.00 1000.00 0.00 r_4153 s_0020[c] + s_1198[c] <=> s_0794[c] + s_1203[c] + s_3750[c] YAL061W -1000.00 1000.00 0.00 r_4154 s_1201[n] + s_3751[n] <=> s_0794[c] + s_3752[n] + s_3753[n] YAL061W -1000.00 1000.00 0.00 -r_4155 s_0437[m] + s_0807[m] + s_3754[m] + s_3755[m] -> s_0397[m] + 2 s_0799[m] + s_0993[m] + s_1326[m] + s_3756[m] YBL080C 0.00 1000.00 0.00 +r_4155 s_0437[m] + s_0807[m] + s_3754[m] + s_3755[m] -> s_0397[m] + s_0799[m] + s_0993[m] + s_1326[m] + s_3756[m] YBL080C 0.00 1000.00 0.00 r_4156 s_0810[v] + s_3757[v] <=> s_3758[v] + s_3759[v] ( YBL091C or YLR244C ) -1000.00 1000.00 0.00 r_4157 s_0803[c] + s_3760[c] <=> s_1322[c] + s_3761[c] ( YBR022W or YMR087W ) -1000.00 1000.00 0.00 r_4158 s_0794[c] + s_1212[c] + 2 s_3762[c] <=> s_1207[c] + 2 s_3763[c] YBR046C -1000.00 1000.00 0.00 @@ -3552,7 +3551,7 @@ r_4181 s_0434[c] + s_0803[c] + s_3801[c] <=> s_0394[c] + s_0794[c] + s_1322[c] r_4183 s_1198[c] + s_3805[c] <=> s_0553[c] + s_0794[c] + s_1203[c] ( YEL070W or YNR073C ) -1000.00 1000.00 0.00 r_4184 s_3806[c] <=> 2 s_1399[c] YER010C -1000.00 1000.00 0.00 r_4185 s_0794[c] + s_1271[c] -> s_0456[c] + s_1399[c] YER010C 0.00 1000.00 0.00 -r_4186 s_0803[c] + s_1029[c] + s_1620[c] <=> s_1616[c] + s_3807[c] YER042W -1000.00 1000.00 0.00 +r_4186 s_0803[c] + s_1029[c] + s_1620[c] <=> s_0794[c] + s_1616[c] + s_3807[c] YER042W -1000.00 1000.00 0.00 r_4187 s_0437[m] + s_1037[m] + s_3808[m] -> s_0424[m] + s_0636[m] + s_3809[m] YER087W 0.00 1000.00 0.00 r_4188 s_0750[c] -> s_0983[c] + s_3810[c] YER163C 0.00 1000.00 0.00 r_4189 s_3811[m] <=> s_0807[m] + s_3812[m] YHL018W -1000.00 1000.00 0.00 @@ -3568,7 +3567,7 @@ r_4198 s_1207[c] + s_3828[c] <=> s_0794[c] + s_1212[c] + s_3829[c] YIR036C -10 r_4199 s_3830[er] + s_3831[er] <=> s_3832[er] + s_3833[er] YIR038C -1000.00 1000.00 0.00 r_4200 s_0750[c] + s_3834[c] <=> s_3835[c] + s_3836[c] ( YMR251W or YKR076W ) -1000.00 1000.00 0.00 r_4201 s_0752[m] + s_4028[m] <=> s_4029[m] + s_4030[m] YLL060C -1000.00 1000.00 0.00 -r_4202 s_0803[c] + s_1029[c] + s_1620[c] <=> s_1616[c] + s_3837[c] YKL069W -1000.00 1000.00 0.00 +r_4202 s_0803[c] + s_1029[c] + s_1620[c] <=> s_0794[c] + s_1616[c] + s_3837[c] YKL069W -1000.00 1000.00 0.00 r_4203 s_0810[v] + s_3838[v] <=> s_3759[v] + s_3839[v] YKL103C -1000.00 1000.00 0.00 r_4204 s_0810[v] + s_3840[v] <=> s_1024[v] + s_3759[v] YKL103C -1000.00 1000.00 0.00 r_4205 s_0434[c] + 2 s_0803[c] + s_3810[c] -> s_0394[c] + s_0794[c] + s_0991[c] + s_1322[c] YKL215C 0.00 1000.00 0.00 @@ -3583,7 +3582,7 @@ r_4214 s_0803[c] + s_0983[c] <=> s_0981[c] + s_1003[c] YFR044C -1000.00 1000.0 r_4215 s_0803[c] + s_3853[c] <=> s_1003[c] + s_3854[c] YFR044C -1000.00 1000.00 0.00 r_4216 s_0714[c] + s_0803[c] <=> s_1322[c] + s_1405[c] YDL024C -1000.00 1000.00 0.00 r_4217 4 s_0799[m] + 4 s_0926[m] + s_1278[m] <=> 2 s_0807[m] + 4 s_3855[m] YDL120W -1000.00 1000.00 0.00 -r_4218 s_0803[c] + s_3856[c] <=> s_1003[c] + s_1582[c] YDL219W -1000.00 1000.00 0.00 +r_4218 s_0803[c] + s_3856[c] <=> s_0794[c] + s_1003[c] + s_1582[c] YDL219W -1000.00 1000.00 0.00 r_4219 s_0803[c] + s_3857[c] <=> s_0794[c] + s_1612[c] + s_3858[c] YDL219W -1000.00 1000.00 0.00 r_4220 s_0803[c] + s_3859[c] <=> s_0794[c] + s_1322[c] + s_3860[c] YDL236W -1000.00 1000.00 0.00 r_4221 s_1198[c] + s_3861[c] <=> s_0794[c] + s_1043[c] + s_1203[c] YDL246C -1000.00 1000.00 0.00 @@ -3600,7 +3599,6 @@ r_4231 s_0803[c] + s_3873[c] <=> s_0419[c] + s_3874[c] YDR242W -1000.00 1000.0 r_4232 s_0434[c] + s_3875[c] -> s_0340[c] + s_0394[c] + s_0794[c] YDR248C 0.00 1000.00 0.00 r_4233 s_1416[c] + s_3876[c] <=> s_1413[c] + s_3877[c] YDR410C -1000.00 1000.00 0.00 r_4234 s_3764[er] + s_3878[er] <=> s_0795[er] + s_3766[er] + s_3879[er] ( YDR437W and YGR216C and YNL038W and YPL076W and YPL175W and YPL096C-A ) -1000.00 1000.00 0.00 -r_4235 s_0434[c] + s_0563[c] -> s_0394[c] + s_0568[c] YDR516C 0.00 1000.00 0.00 r_4236 s_0025[c] + s_0794[c] <=> s_0803[c] + s_1151[c] ( YDR533C or YMR322C or YOR391C or YPL280W ) -1000.00 1000.00 0.00 r_4237 s_0810[v] + s_3880[c] + s_3881[v] -> s_0802[v] + s_1329[v] + s_3882[v] + s_3883[v] YGL006W 0.00 1000.00 0.00 r_4238 s_0806[g] + s_3880[c] + s_4196[g] -> s_0797[g] + s_1325[g] + s_4197[g] + s_4198[g] YGL167C 0.00 1000.00 0.00 @@ -3615,10 +3613,10 @@ r_4246 s_0810[v] + s_3900[v] -> s_3901[v] + s_3902[v] YGL156W 0.00 1000.00 r_4247 s_0434[c] + s_0445[c] + s_1045[c] -> s_0633[c] + s_0803[c] + s_3903[c] YGL169W 0.00 1000.00 0.00 r_4248 s_3904[c] <=> s_0419[c] + s_1399[c] YGL196W -1000.00 1000.00 0.00 r_4249 s_3905[m] + s_3906[m] <=> s_0365[m] + s_3785[m] YGR012W -1000.00 1000.00 0.00 -r_4250 s_0804[er] + s_3888[er] <=> s_0646[er] + s_1323[er] YGR036C -1000.00 1000.00 0.00 -r_4251 s_0541[m] + s_3907[m] <=> s_0636[m] + s_0799[m] + s_3908[m] YGR046W -1000.00 1000.00 0.00 +r_4250 s_0795[er] + s_0804[er] + s_3888[er] <=> s_0646[er] + s_1323[er] YGR036C -1000.00 1000.00 0.00 +r_4251 s_0541[m] + s_0799[m] + s_3907[m] <=> s_0636[m] + s_3908[m] YGR046W -1000.00 1000.00 0.00 r_4252 s_1003[c] + s_1198[c] + s_3909[c] <=> 3 s_0803[c] + s_1216[c] + s_3910[c] YGR144W -1000.00 1000.00 0.00 -r_4253 s_3911[er] + s_3912[er] <=> s_0646[er] + s_0795[er] + s_3887[er] YGR227W -1000.00 1000.00 0.00 +r_4253 s_0795[er] + s_3911[er] + s_3912[er] <=> s_0646[er] + s_3887[er] YGR227W -1000.00 1000.00 0.00 r_4254 s_1203[c] + 2 s_1275[c] + 2 s_3913[c] -> s_0794[c] + s_1198[c] + 2 s_3914[c] YGR234W 0.00 1000.00 0.00 r_4255 s_1212[c] + 2 s_1275[c] + 2 s_3913[c] -> s_0794[c] + s_1207[c] + 2 s_3914[c] YGR234W 0.00 1000.00 0.00 r_4256 s_0434[c] + s_0794[c] + s_3915[c] -> s_0633[c] + s_3916[c] YJL046W 0.00 1000.00 0.00 @@ -3642,7 +3640,7 @@ r_4275 s_1212[c] + 2 s_3936[e] <=> s_0794[c] + 2 s_0924[c] + s_1207[c] ( YLR04 r_4276 s_1212[c] + 2 s_4031[v] <=> s_0794[c] + 2 s_0924[c] + s_1207[c] YLL051C -1000.00 1000.00 0.00 r_4277 s_3937[er] + s_3938[er] <=> s_0530[er] + s_3939[er] ( YLR099C or YPR139C ) -1000.00 1000.00 0.00 r_4278 s_0419[c] + s_0434[c] + s_3940[c] -> s_0423[c] + s_0633[c] + s_0794[c] + s_3941[c] YLR143W 0.00 1000.00 0.00 -r_4279 s_0801[p] + s_0809[p] + s_3942[p] <=> s_0638[p] + s_3943[p] YLR151C -1000.00 1000.00 0.00 +r_4279 s_0809[p] + s_3942[p] <=> s_0638[p] + s_0801[p] + s_3943[p] YLR151C -1000.00 1000.00 0.00 r_4280 s_1254[m] + s_3944[m] <=> s_1845[m] + s_3945[m] YLR239C -1000.00 1000.00 0.00 r_4281 s_3944[m] + s_3946[m] <=> s_1845[m] + s_3947[m] YLR239C -1000.00 1000.00 0.00 r_4282 s_0434[c] + s_3948[c] -> s_0394[c] + s_0442[c] + s_0794[c] YLR345W 0.00 1000.00 0.00 @@ -3658,38 +3656,38 @@ r_4293 s_0274[c] + s_0803[c] + s_1198[c] -> s_0734[c] + 2 s_0794[c] + s_1203[c] r_4294 s_0803[c] + s_0850[c] + s_1198[c] -> 2 s_0794[c] + s_0853[c] + s_1203[c] YMR110C 0.00 1000.00 0.00 r_4295 s_0803[c] + s_1198[c] + s_3959[c] <=> 2 s_0794[c] + s_1203[c] + s_3960[c] YMR110C -1000.00 1000.00 0.00 r_4296 2 s_0803[c] + s_1198[c] + s_3961[c] <=> 3 s_0794[c] + s_1203[c] + s_3962[c] YMR110C -1000.00 1000.00 0.00 -r_4297 s_0803[c] + s_1198[c] + s_3963[c] <=> s_0794[c] + s_1203[c] + s_3964[c] YMR110C -1000.00 1000.00 0.00 +r_4297 s_0803[c] + s_1198[c] + s_3963[c] <=> 2 s_0794[c] + s_1203[c] + s_3964[c] YMR110C -1000.00 1000.00 0.00 r_4298 s_0803[c] + s_1198[c] + s_3965[c] <=> 2 s_0794[c] + s_1203[c] + s_3966[c] YMR110C -1000.00 1000.00 0.00 -r_4299 s_0803[c] + s_1198[c] + s_3967[c] <=> s_0794[c] + s_1203[c] + s_3968[c] YMR110C -1000.00 1000.00 0.00 +r_4299 s_0803[c] + s_1198[c] + s_3967[c] <=> 2 s_0794[c] + s_1203[c] + s_3968[c] YMR110C -1000.00 1000.00 0.00 r_4300 s_0803[c] + s_1198[c] + s_3969[c] <=> 2 s_0794[c] + s_1203[c] + s_3970[c] YMR110C -1000.00 1000.00 0.00 -r_4301 s_0803[c] + s_1198[c] + s_3971[c] <=> s_0794[c] + s_1203[c] + s_3972[c] YMR110C -1000.00 1000.00 0.00 +r_4301 s_0803[c] + s_1198[c] + s_3971[c] <=> 2 s_0794[c] + s_1203[c] + s_3972[c] YMR110C -1000.00 1000.00 0.00 r_4302 s_0803[c] + s_1198[c] + s_3973[c] <=> 2 s_0794[c] + s_1203[c] + s_3974[c] YMR110C -1000.00 1000.00 0.00 -r_4303 s_0803[c] + s_3975[c] <=> 2 s_0794[c] + s_3976[c] YMR110C -1000.00 1000.00 0.00 -r_4304 s_0803[c] + s_3977[c] <=> 2 s_0794[c] + s_3978[c] YMR110C -1000.00 1000.00 0.00 -r_4305 s_0803[c] + s_1198[c] + s_3979[c] <=> s_0794[c] + s_1203[c] + s_3980[c] YMR110C -1000.00 1000.00 0.00 -r_4306 s_0803[c] + s_1198[c] + s_3981[c] <=> s_0794[c] + s_1203[c] + s_3982[c] YMR110C -1000.00 1000.00 0.00 -r_4307 s_0803[c] + s_1198[c] + s_3983[c] <=> s_0794[c] + s_1203[c] + s_3984[c] YMR110C -1000.00 1000.00 0.00 +r_4303 s_0803[c] + s_1198[c] + s_3975[c] <=> 2 s_0794[c] + s_1203[c] + s_3976[c] YMR110C -1000.00 1000.00 0.00 +r_4304 s_0803[c] + s_1198[c] + s_3977[c] <=> 2 s_0794[c] + s_1203[c] + s_3978[c] YMR110C -1000.00 1000.00 0.00 +r_4305 s_0803[c] + s_1198[c] + s_3979[c] <=> 2 s_0794[c] + s_1203[c] + s_3980[c] YMR110C -1000.00 1000.00 0.00 +r_4306 s_0803[c] + s_1198[c] + s_3981[c] <=> 2 s_0794[c] + s_1203[c] + s_3982[c] YMR110C -1000.00 1000.00 0.00 +r_4307 s_0803[c] + s_1198[c] + s_3983[c] <=> 2 s_0794[c] + s_1203[c] + s_3984[c] YMR110C -1000.00 1000.00 0.00 r_4308 s_2808[erm] + s_2831[erm] + s_3985[erm] -> s_2783[erm] + s_2966[erm] + s_3986[gm] + s_3987[erm] YMR162C 0.00 1000.00 0.00 r_4309 s_0803[c] + s_3988[c] -> s_0765[c] + s_0794[c] + s_1260[c] YMR210W 0.00 1000.00 0.00 r_4310 2 s_3890[er] + s_3896[er] <=> 2 s_0795[er] + 2 s_3892[er] + s_3989[er] YNL048W -1000.00 1000.00 0.00 r_4311 2 s_3890[er] + s_3989[er] <=> 2 s_0795[er] + 2 s_3892[er] + s_3990[er] YNL048W -1000.00 1000.00 0.00 r_4312 s_1416[c] + s_3991[c] <=> s_0794[c] + s_1413[c] + s_3992[c] YNL092W -1000.00 1000.00 0.00 -r_4313 s_0644[er] + s_3993[er] <=> s_0646[er] + s_0795[er] + s_3994[er] YNL219C -1000.00 1000.00 0.00 +r_4313 s_0644[er] + s_3993[er] <=> s_0646[er] + s_3994[er] YNL219C -1000.00 1000.00 0.00 r_4314 s_0644[er] + s_3995[er] <=> s_0646[er] + s_3996[er] YNL219C -1000.00 1000.00 0.00 r_4315 s_1198[c] + s_3997[c] <=> s_0779[c] + s_0794[c] + s_1203[c] YNL274C -1000.00 1000.00 0.00 r_4316 s_0644[er] + s_3994[er] <=> s_0646[er] + s_3995[er] YNR030W -1000.00 1000.00 0.00 r_4317 s_0803[c] + s_3998[c] <=> s_0553[c] + s_0563[c] YOL157C -1000.00 1000.00 0.00 r_4318 s_0803[c] + s_3999[c] <=> s_0563[c] + s_3951[c] YOL157C -1000.00 1000.00 0.00 r_4319 2 s_0803[c] + s_4000[c] <=> 2 s_0563[c] YOL157C -1000.00 1000.00 0.00 -r_4320 s_3911[er] + s_3996[er] <=> s_0646[er] + s_0795[er] + s_4001[er] YOR002W -1000.00 1000.00 0.00 -r_4321 s_3911[er] + s_4001[er] <=> s_0646[er] + s_0795[er] + s_3912[er] YOR067C -1000.00 1000.00 0.00 +r_4320 s_0795[er] + s_3911[er] + s_3996[er] <=> s_0646[er] + s_4001[er] YOR002W -1000.00 1000.00 0.00 +r_4321 s_0795[er] + s_3911[er] + s_4001[er] <=> s_0646[er] + s_3912[er] YOR067C -1000.00 1000.00 0.00 r_4322 s_0644[er] + s_4002[er] <=> s_0646[er] + s_0795[er] + s_4003[er] YOR149C -1000.00 1000.00 0.00 r_4323 2 s_1419[m] + s_3945[m] + 2 s_4004[m] <=> 2 s_1031[m] + s_3947[m] + 2 s_4005[m] YOR196C -1000.00 1000.00 0.00 r_4324 s_1254[m] + 2 s_1419[m] + 2 s_4004[m] <=> 2 s_1031[m] + s_3946[m] + 2 s_4005[m] YOR196C -1000.00 1000.00 0.00 r_4325 s_4006[m] + s_4007[m] -> s_4008[m] ( YOR226C or YPL135W ) 0.00 1000.00 0.00 -r_4326 s_4009[m] + s_4010[m] <=> s_0799[m] + s_4011[m] + s_4012[m] ( YOR251C or YOR285W or YOR286W ) -1000.00 1000.00 0.00 +r_4326 s_4009[m] + s_4010[m] <=> 2 s_0799[m] + s_4011[m] + s_4012[m] ( YOR251C or YOR285W or YOR286W ) -1000.00 1000.00 0.00 r_4327 s_4013[c] <=> s_4014[m] ( YOR334W or YPL060W ) -1000.00 1000.00 0.00 -r_4328 s_0646[er] + s_4015[er] <=> s_3766[er] + s_3911[er] YPL227C -1000.00 1000.00 0.00 +r_4328 s_0646[er] + s_4015[er] <=> 2 s_0795[er] + s_3766[er] + s_3911[er] YPL227C -1000.00 1000.00 0.00 r_4329 s_1467[c] <=> s_4016[er] YPR003C -1000.00 1000.00 0.00 r_4330 s_1207[c] + s_1396[c] <=> s_0794[c] + s_1212[c] + s_1392[c] YPR127W -1000.00 1000.00 0.00 r_4331 s_0509[c] + s_0803[c] <=> s_4017[c] ( YDR371W or YLR286C ) -1000.00 1000.00 0.00 @@ -3735,7 +3733,7 @@ r_4370 s_0803[c] + s_4100[c] -> s_0543[c] + s_1322[c] 0.00 1000.00 0.00 r_4371 s_0796[e] + s_4101[e] <=> s_0794[c] + s_4100[c] -1000.00 1000.00 0.00 r_4372 s_0803[c] + s_4102[c] -> s_0794[c] + s_4081[c] 0.00 1000.00 0.00 r_4373 s_0796[e] + s_4103[e] <=> s_0794[c] + s_4102[c] -1000.00 1000.00 0.00 -r_4374 s_0803[c] + s_4104[c] -> s_0955[c] + s_1469[c] 0.00 1000.00 0.00 +r_4374 s_0803[c] + s_4104[c] -> s_0794[c] + s_0955[c] + s_1469[c] 0.00 1000.00 0.00 r_4375 s_0796[e] + s_4105[e] <=> s_0794[c] + s_4104[c] -1000.00 1000.00 0.00 r_4376 s_0803[c] + s_4106[c] -> s_0386[c] + s_1322[c] 0.00 1000.00 0.00 r_4377 s_4107[e] <=> s_4106[c] -1000.00 1000.00 0.00 @@ -3743,7 +3741,7 @@ r_4378 s_0803[c] + s_4108[c] -> s_0553[c] + s_0563[c] 0.00 1000.00 0.00 r_4379 s_0796[e] + s_4109[e] <=> s_0794[c] + s_4108[c] -1000.00 1000.00 0.00 r_4380 s_0529[c] + s_0794[c] + s_4110[c] <=> s_0373[c] + s_0981[c] -1000.00 1000.00 0.00 r_4381 s_0796[e] + s_4111[e] <=> s_0794[c] + s_4110[c] -1000.00 1000.00 0.00 -r_4382 2 s_0709[m] + s_4112[c] <=> 2 s_0710[m] + 2 s_4113[c] -1000.00 1000.00 0.00 +r_4382 2 s_0709[m] + 2 s_4113[c] <=> 2 s_0710[m] + s_4112[c] -1000.00 1000.00 0.00 r_4383 s_4114[e] <=> s_4112[c] -1000.00 1000.00 0.00 r_4384 s_0794[c] + s_1212[c] + s_4117[c] -> s_1207[c] + s_3875[c] 0.00 1000.00 0.00 r_4385 s_0796[e] + s_4118[e] <=> s_0794[c] + s_4117[c] -1000.00 1000.00 0.00 @@ -3772,7 +3770,7 @@ r_4407 s_0803[c] + s_4077[c] <=> s_1322[c] + s_3904[c] -1000.00 1000.00 0.0 r_4408 s_0796[e] + s_4037[e] <=> s_0794[c] + s_4038[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4409 s_0810[v] + s_4039[v] -> s_0996[v] + s_3759[v] 0.00 1000.00 0.00 r_4410 s_4136[c] <=> s_0779[c] + s_1271[c] -1000.00 1000.00 0.00 -r_4411 s_0803[c] + s_4138[c] -> s_0419[c] + s_1399[c] + s_1469[c] 0.00 1000.00 0.00 +r_4411 s_0803[c] + s_4138[c] -> s_0419[c] + s_0794[c] + s_1399[c] + s_1469[c] 0.00 1000.00 0.00 r_4412 s_0803[c] + s_4094[c] -> s_0794[c] + s_4066[c] 0.00 1000.00 0.00 r_4413 s_0803[c] + s_4044[c] -> s_1322[c] + s_1493[c] 0.00 1000.00 0.00 r_4414 s_0810[v] + s_4036[v] -> s_1002[v] + s_3759[v] 0.00 1000.00 0.00 @@ -3793,7 +3791,7 @@ r_4428 s_0796[e] + s_4097[e] <=> s_0794[c] + s_4096[c] -1000.00 1000.00 0.0 r_4429 s_0796[e] + s_4050[e] <=> s_0794[c] + s_4051[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4430 s_0794[c] + s_4051[c] <=> s_0802[v] + s_4052[v] -1000.00 1000.00 0.00 r_4431 s_0794[c] + s_4120[c] <=> s_0802[v] + s_4121[v] -1000.00 1000.00 0.00 -r_4432 s_0717[c] + s_1275[c] + s_4115[c] -> s_0714[c] + s_0775[c] + s_0794[c] + s_0803[c] + s_1469[c] 0.00 1000.00 0.00 +r_4432 s_0717[c] + s_1275[c] + s_4115[c] -> s_0714[c] + s_0775[c] + 2 s_0794[c] + s_0803[c] + s_1469[c] 0.00 1000.00 0.00 r_4433 s_4045[e] <=> s_4044[c] -1000.00 1000.00 0.00 r_4434 s_4047[e] <=> s_4046[c] -1000.00 1000.00 0.00 r_4435 s_0803[c] + s_4048[c] -> s_0765[c] + s_1322[c] ( YIL053W or YER062C ) 0.00 1000.00 0.00 @@ -3928,18 +3926,18 @@ r_4563 s_4084[e] -> 0.00 1000.00 0.00 r_4564 s_4127[e] -> 0.00 1000.00 0.00 r_4565 s_4103[e] -> 0.00 1000.00 0.00 r_4566 s_0340[c] + s_0394[c] + s_0794[c] -> s_0434[c] + s_3875[c] 0.00 1000.00 0.00 -r_4567 s_0340[c] -> s_1322[c] + s_3875[c] 0.00 1000.00 0.00 +r_4567 s_0340[c] + s_0803[c] -> s_1322[c] + s_3875[c] 0.00 1000.00 0.00 r_4568 s_0794[c] + s_1321[c] -> s_4194[c] 0.00 1000.00 0.00 r_4569 s_0362[c] + s_0794[c] + s_4195[c] -> s_0803[c] + s_4194[c] 0.00 1000.00 0.00 r_4570 s_1198[c] + s_4182[c] <=> s_0180[c] + s_0794[c] + s_1203[c] -1000.00 1000.00 0.00 -r_4571 s_4182[c] <=> s_0779[c] + 3 s_0794[c] + s_4183[c] -1000.00 1000.00 0.00 +r_4571 s_0529[c] + s_0794[c] + s_4182[c] <=> s_0779[c] + s_0803[c] + s_4183[c] -1000.00 1000.00 0.00 r_4572 s_0180[c] + s_0441[c] <=> s_0991[c] + s_4184[c] -1000.00 1000.00 0.00 r_4573 s_0529[c] + s_1198[c] + s_4184[c] -> s_0373[c] + s_0456[c] + s_1203[c] 0.00 1000.00 0.00 r_4574 s_0529[c] + s_1207[c] + s_4184[c] -> s_0373[c] + s_0456[c] + s_1212[c] 0.00 1000.00 0.00 r_4575 s_0794[c] + s_4184[c] -> s_0359[c] + s_0456[c] 0.00 1000.00 0.00 r_4576 s_1207[c] + s_4185[c] <=> s_0794[c] + s_1212[c] + s_4186[c] -1000.00 1000.00 0.00 -r_4577 s_0232[c] -> s_4186[c] 0.00 1000.00 0.00 -r_4578 s_1212[c] + s_4187[c] -> s_0794[c] + s_1207[c] + s_4186[c] 0.00 1000.00 0.00 +r_4577 s_0232[c] + s_0803[c] -> s_4208[c] 0.00 1000.00 0.00 +r_4578 s_0794[c] + s_1212[c] + s_4187[c] -> s_1207[c] + s_4185[c] 0.00 1000.00 0.00 r_4579 s_0794[c] + 2 s_1399[c] -> s_0456[c] + s_4188[c] 0.00 1000.00 0.00 r_4580 s_1207[c] + s_4185[c] <=> s_0794[c] + s_1212[c] + s_4188[c] -1000.00 1000.00 0.00 r_4581 s_1198[c] + s_4189[c] -> s_0178[c] + s_0456[c] + s_1203[c] 0.00 1000.00 0.00 diff --git a/ModelFiles/xml/yeastGEM.xml b/ModelFiles/xml/yeastGEM.xml index b8f8d2e9..ffa9925c 100644 --- a/ModelFiles/xml/yeastGEM.xml +++ b/ModelFiles/xml/yeastGEM.xml @@ -33,6 +33,7 @@ + @@ -53,6 +54,7 @@ + @@ -73,6 +75,7 @@ + @@ -93,6 +96,7 @@ + @@ -113,6 +117,7 @@ + @@ -133,6 +138,7 @@ + @@ -153,6 +159,7 @@ + @@ -173,6 +180,7 @@ + @@ -193,6 +201,7 @@ + @@ -213,6 +222,7 @@ + @@ -233,6 +243,7 @@ + @@ -247,7 +258,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -266,7 +282,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -286,14 +307,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -311,6 +338,7 @@ + @@ -325,12 +353,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -351,6 +385,7 @@ + @@ -371,6 +406,7 @@ + @@ -391,6 +427,7 @@ + @@ -411,6 +448,7 @@ + @@ -431,6 +469,7 @@ + @@ -451,6 +490,7 @@ + @@ -471,6 +511,7 @@ + @@ -491,6 +532,7 @@ + @@ -511,6 +553,7 @@ + @@ -531,6 +574,7 @@ + @@ -551,6 +595,7 @@ + @@ -571,6 +616,7 @@ + @@ -591,6 +637,7 @@ + @@ -611,6 +658,7 @@ + @@ -631,6 +679,7 @@ + @@ -651,6 +700,7 @@ + @@ -671,6 +721,7 @@ + @@ -691,6 +742,7 @@ + @@ -711,6 +763,7 @@ + @@ -731,6 +784,7 @@ + @@ -751,6 +805,7 @@ + @@ -771,6 +826,7 @@ + @@ -785,12 +841,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -805,7 +867,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -824,12 +891,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -844,12 +917,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -864,12 +943,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -890,6 +975,7 @@ + @@ -910,6 +996,7 @@ + @@ -930,6 +1017,7 @@ + @@ -950,6 +1038,7 @@ + @@ -970,6 +1059,7 @@ + @@ -990,6 +1080,7 @@ + @@ -1010,6 +1101,7 @@ + @@ -1030,6 +1122,7 @@ + @@ -1050,6 +1143,7 @@ + @@ -1070,6 +1164,7 @@ + @@ -1090,6 +1185,7 @@ + @@ -1110,6 +1206,7 @@ + @@ -1130,6 +1227,7 @@ + @@ -1150,6 +1248,7 @@ + @@ -1170,6 +1269,7 @@ + @@ -1190,6 +1290,7 @@ + @@ -1210,6 +1311,7 @@ + @@ -1230,6 +1332,7 @@ + @@ -1250,6 +1353,7 @@ + @@ -1270,6 +1374,7 @@ + @@ -1290,6 +1395,7 @@ + @@ -1315,6 +1421,7 @@ + @@ -1330,14 +1437,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -1350,14 +1463,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -1375,6 +1494,7 @@ + @@ -1395,6 +1515,7 @@ + @@ -1415,6 +1536,7 @@ + @@ -1435,6 +1557,7 @@ + @@ -1455,6 +1578,7 @@ + @@ -1475,6 +1599,7 @@ + @@ -1495,6 +1620,7 @@ + @@ -1515,6 +1641,7 @@ + @@ -1535,6 +1662,7 @@ + @@ -1555,6 +1683,7 @@ + @@ -1575,6 +1704,7 @@ + @@ -1595,6 +1725,7 @@ + @@ -1615,6 +1746,7 @@ + @@ -1635,6 +1767,7 @@ + @@ -1655,6 +1788,7 @@ + @@ -1675,6 +1809,7 @@ + @@ -1695,6 +1830,7 @@ + @@ -1715,6 +1851,7 @@ + @@ -1735,6 +1872,7 @@ + @@ -1755,6 +1893,7 @@ + @@ -1775,6 +1914,7 @@ + @@ -1795,6 +1935,7 @@ + @@ -1809,13 +1950,20 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + @@ -1834,6 +1982,7 @@ + @@ -1854,6 +2003,7 @@ + @@ -1874,6 +2024,7 @@ + @@ -1908,13 +2059,20 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + @@ -1933,6 +2091,7 @@ + @@ -1953,6 +2112,7 @@ + @@ -1973,6 +2133,7 @@ + @@ -1993,6 +2154,7 @@ + @@ -2013,6 +2175,7 @@ + @@ -2033,6 +2196,7 @@ + @@ -2053,6 +2217,7 @@ + @@ -2073,6 +2238,7 @@ + @@ -2093,6 +2259,7 @@ + @@ -2107,12 +2274,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -2133,6 +2306,7 @@ + @@ -2152,6 +2326,7 @@ + @@ -2172,6 +2347,7 @@ + @@ -2192,6 +2368,7 @@ + @@ -2212,6 +2389,7 @@ + @@ -2232,6 +2410,7 @@ + @@ -2252,6 +2431,7 @@ + @@ -2272,6 +2452,7 @@ + @@ -2292,6 +2473,7 @@ + @@ -2311,6 +2493,7 @@ + @@ -2330,6 +2513,7 @@ + @@ -2349,6 +2533,7 @@ + @@ -2368,6 +2553,7 @@ + @@ -2387,6 +2573,7 @@ + @@ -2407,6 +2594,7 @@ + @@ -2427,6 +2615,7 @@ + @@ -2447,6 +2636,7 @@ + @@ -2467,6 +2657,7 @@ + @@ -2487,6 +2678,7 @@ + @@ -2507,6 +2699,7 @@ + @@ -2527,6 +2720,7 @@ + @@ -2547,6 +2741,7 @@ + @@ -2567,6 +2762,7 @@ + @@ -2587,6 +2783,7 @@ + @@ -2607,6 +2804,7 @@ + @@ -2627,6 +2825,7 @@ + @@ -2647,6 +2846,7 @@ + @@ -2667,6 +2867,7 @@ + @@ -2687,6 +2888,7 @@ + @@ -2707,6 +2909,7 @@ + @@ -2727,6 +2930,7 @@ + @@ -2747,6 +2951,7 @@ + @@ -2761,12 +2966,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -2787,6 +2998,7 @@ + @@ -2801,12 +3013,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -2827,6 +3045,7 @@ + @@ -2847,6 +3066,7 @@ + @@ -2867,6 +3087,7 @@ + @@ -2887,6 +3108,7 @@ + @@ -2907,6 +3129,7 @@ + @@ -2927,6 +3150,7 @@ + @@ -2947,6 +3171,7 @@ + @@ -2987,6 +3212,7 @@ + @@ -3007,6 +3233,7 @@ + @@ -3027,6 +3254,7 @@ + @@ -3047,6 +3275,7 @@ + @@ -3067,6 +3296,7 @@ + @@ -3081,12 +3311,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -3101,12 +3337,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -3140,15 +3382,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -3160,15 +3408,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -3186,6 +3440,7 @@ + @@ -3206,6 +3461,7 @@ + @@ -3220,12 +3476,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -3246,6 +3508,7 @@ + @@ -3266,6 +3529,7 @@ + @@ -3286,6 +3550,7 @@ + @@ -3306,6 +3571,7 @@ + @@ -3326,6 +3592,7 @@ + @@ -3346,6 +3613,7 @@ + @@ -3360,12 +3628,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -3380,12 +3654,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -3399,12 +3679,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -3419,12 +3705,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -3445,6 +3737,7 @@ + @@ -3459,12 +3752,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -3485,6 +3784,7 @@ + @@ -3505,6 +3805,7 @@ + @@ -3525,6 +3826,7 @@ + @@ -3545,6 +3847,7 @@ + @@ -3565,6 +3868,7 @@ + @@ -3579,7 +3883,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -3604,6 +3913,7 @@ + @@ -3624,6 +3934,7 @@ + @@ -3644,6 +3955,7 @@ + @@ -3658,12 +3970,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -3684,6 +4002,7 @@ + @@ -3704,6 +4023,7 @@ + @@ -3724,6 +4044,7 @@ + @@ -3744,6 +4065,7 @@ + @@ -3764,6 +4086,7 @@ + @@ -3784,6 +4107,7 @@ + @@ -3798,14 +4122,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + - + + @@ -3823,6 +4153,7 @@ + @@ -3843,6 +4174,7 @@ + @@ -3863,6 +4195,7 @@ + @@ -3883,6 +4216,7 @@ + @@ -3903,6 +4237,7 @@ + @@ -3923,6 +4258,7 @@ + @@ -3943,6 +4279,7 @@ + @@ -3963,6 +4300,7 @@ + @@ -3983,6 +4321,7 @@ + @@ -4003,6 +4342,7 @@ + @@ -4023,6 +4363,7 @@ + @@ -4043,6 +4384,7 @@ + @@ -4063,6 +4405,7 @@ + @@ -4077,12 +4420,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -4103,6 +4452,7 @@ + @@ -4117,7 +4467,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -4143,6 +4498,7 @@ + @@ -4163,6 +4519,7 @@ + @@ -4178,14 +4535,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -4203,6 +4566,7 @@ + @@ -4223,6 +4587,7 @@ + @@ -4243,6 +4608,7 @@ + @@ -4263,6 +4629,7 @@ + @@ -4283,6 +4650,7 @@ + @@ -4298,14 +4666,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -4318,14 +4692,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -4337,15 +4717,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -4357,7 +4743,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -4382,6 +4773,7 @@ + @@ -4402,6 +4794,7 @@ + @@ -4422,6 +4815,7 @@ + @@ -4442,6 +4836,7 @@ + @@ -4462,6 +4857,7 @@ + @@ -4482,6 +4878,7 @@ + @@ -4502,6 +4899,7 @@ + @@ -4522,6 +4920,7 @@ + @@ -4542,6 +4941,7 @@ + @@ -4562,6 +4962,7 @@ + @@ -4582,6 +4983,7 @@ + @@ -4602,6 +5004,7 @@ + @@ -4622,6 +5025,7 @@ + @@ -4642,6 +5046,7 @@ + @@ -4662,6 +5067,7 @@ + @@ -4682,6 +5088,7 @@ + @@ -4702,6 +5109,7 @@ + @@ -4722,6 +5130,7 @@ + @@ -4742,6 +5151,7 @@ + @@ -4762,6 +5172,7 @@ + @@ -4795,15 +5206,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -4834,14 +5251,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + - + + @@ -4878,6 +5301,7 @@ + @@ -4955,6 +5379,7 @@ + @@ -4969,12 +5394,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -4989,12 +5420,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -5015,6 +5452,7 @@ + @@ -5035,6 +5473,7 @@ + @@ -5055,6 +5494,7 @@ + @@ -5075,6 +5515,7 @@ + @@ -5090,14 +5531,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -5110,14 +5557,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -5135,6 +5588,7 @@ + @@ -5155,6 +5609,7 @@ + @@ -5175,6 +5630,7 @@ + @@ -5195,6 +5651,7 @@ + @@ -5215,6 +5672,7 @@ + @@ -5235,6 +5693,7 @@ + @@ -5255,6 +5714,7 @@ + @@ -5275,6 +5735,7 @@ + @@ -5295,6 +5756,7 @@ + @@ -5315,6 +5777,7 @@ + @@ -5335,6 +5798,7 @@ + @@ -5355,6 +5819,7 @@ + @@ -5375,6 +5840,7 @@ + @@ -5395,6 +5861,7 @@ + @@ -5415,6 +5882,7 @@ + @@ -5435,6 +5903,7 @@ + @@ -5455,6 +5924,7 @@ + @@ -5475,6 +5945,7 @@ + @@ -5495,6 +5966,7 @@ + @@ -5515,6 +5987,7 @@ + @@ -5535,6 +6008,7 @@ + @@ -5555,6 +6029,7 @@ + @@ -5575,6 +6050,7 @@ + @@ -5595,6 +6071,7 @@ + @@ -5615,6 +6092,7 @@ + @@ -5635,6 +6113,7 @@ + @@ -5649,12 +6128,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -5675,6 +6160,7 @@ + @@ -5695,6 +6181,7 @@ + @@ -5715,6 +6202,7 @@ + @@ -5735,6 +6223,7 @@ + @@ -5755,6 +6244,7 @@ + @@ -5775,6 +6265,7 @@ + @@ -5795,6 +6286,7 @@ + @@ -5815,6 +6307,7 @@ + @@ -5835,6 +6328,7 @@ + @@ -5855,6 +6349,7 @@ + @@ -5875,6 +6370,7 @@ + @@ -5889,12 +6385,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -5915,6 +6417,7 @@ + @@ -5935,6 +6438,7 @@ + @@ -5955,6 +6459,7 @@ + @@ -5975,6 +6480,7 @@ + @@ -5995,6 +6501,7 @@ + @@ -6015,6 +6522,7 @@ + @@ -6035,6 +6543,7 @@ + @@ -6049,15 +6558,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -6069,15 +6584,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -6089,7 +6610,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -6115,6 +6641,7 @@ + @@ -6135,6 +6662,7 @@ + @@ -6155,6 +6683,7 @@ + @@ -6175,6 +6704,7 @@ + @@ -6195,6 +6725,7 @@ + @@ -6215,6 +6746,7 @@ + @@ -6235,6 +6767,7 @@ + @@ -6255,6 +6788,7 @@ + @@ -6275,6 +6809,7 @@ + @@ -6295,6 +6830,7 @@ + @@ -6315,6 +6851,7 @@ + @@ -6335,6 +6872,7 @@ + @@ -6349,12 +6887,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -6369,12 +6913,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -6389,12 +6939,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -6409,12 +6965,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -6429,12 +6991,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -6449,12 +7017,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -6475,6 +7049,7 @@ + @@ -6495,6 +7070,7 @@ + @@ -6515,6 +7091,7 @@ + @@ -6535,6 +7112,7 @@ + @@ -6555,6 +7133,7 @@ + @@ -6575,6 +7154,7 @@ + @@ -6595,6 +7175,7 @@ + @@ -6609,12 +7190,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -6629,12 +7216,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -6655,6 +7248,7 @@ + @@ -6675,6 +7269,7 @@ + @@ -6695,6 +7290,7 @@ + @@ -6715,6 +7311,7 @@ + @@ -6733,6 +7330,11 @@ + + + + + @@ -6748,6 +7350,7 @@ + @@ -6768,6 +7371,7 @@ + @@ -6788,6 +7392,7 @@ + @@ -6808,6 +7413,7 @@ + @@ -6828,6 +7434,7 @@ + @@ -6848,6 +7455,7 @@ + @@ -6868,6 +7476,7 @@ + @@ -6888,6 +7497,7 @@ + @@ -6908,6 +7518,7 @@ + @@ -6928,6 +7539,7 @@ + @@ -6948,6 +7560,7 @@ + @@ -6968,6 +7581,7 @@ + @@ -6988,6 +7602,7 @@ + @@ -7008,6 +7623,7 @@ + @@ -7022,12 +7638,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -7048,6 +7670,7 @@ + @@ -7068,6 +7691,7 @@ + @@ -7087,6 +7711,7 @@ + @@ -7106,6 +7731,7 @@ + @@ -7125,6 +7751,7 @@ + @@ -7144,6 +7771,7 @@ + @@ -7163,6 +7791,7 @@ + @@ -7182,6 +7811,7 @@ + @@ -7201,6 +7831,7 @@ + @@ -7220,6 +7851,7 @@ + @@ -7239,6 +7871,7 @@ + @@ -7258,6 +7891,7 @@ + @@ -7277,6 +7911,7 @@ + @@ -7410,6 +8045,7 @@ + @@ -7429,6 +8065,7 @@ + @@ -7448,6 +8085,7 @@ + @@ -7467,6 +8105,7 @@ + @@ -7486,6 +8125,7 @@ + @@ -7505,6 +8145,7 @@ + @@ -7638,6 +8279,7 @@ + @@ -7657,6 +8299,7 @@ + @@ -7671,12 +8314,18 @@ - + + + +

NOTES: alternative MetaNetX ID MNXM48488 (PR #220) | metFormula curated (PR #222)

+ + + @@ -7697,6 +8346,7 @@ + @@ -7717,6 +8367,7 @@ + @@ -7737,6 +8388,7 @@ + @@ -7757,6 +8409,7 @@ + @@ -7777,6 +8430,7 @@ + @@ -7797,6 +8451,7 @@ + @@ -7817,6 +8472,7 @@ + @@ -7837,6 +8493,7 @@ + @@ -7857,6 +8514,7 @@ + @@ -7877,6 +8535,7 @@ + @@ -7897,6 +8556,7 @@ + @@ -7917,6 +8577,7 @@ + @@ -7937,6 +8598,7 @@ + @@ -7957,6 +8619,7 @@ + @@ -7977,6 +8640,7 @@ + @@ -7997,6 +8661,7 @@ + @@ -8017,6 +8682,7 @@ + @@ -8037,6 +8703,7 @@ + @@ -8057,6 +8724,7 @@ + @@ -8077,6 +8745,7 @@ + @@ -8097,6 +8766,7 @@ + @@ -8117,6 +8787,7 @@ + @@ -8131,12 +8802,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -8157,6 +8834,7 @@ + @@ -8177,6 +8855,7 @@ + @@ -8197,6 +8876,7 @@ + @@ -8217,6 +8897,7 @@ + @@ -8237,6 +8918,7 @@ + @@ -8257,6 +8939,7 @@ + @@ -8277,6 +8960,7 @@ + @@ -8297,6 +8981,7 @@ + @@ -8317,6 +9002,7 @@ + @@ -8337,6 +9023,7 @@ + @@ -8357,6 +9044,7 @@ + @@ -8377,6 +9065,7 @@ + @@ -8391,15 +9080,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -8411,15 +9106,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -8432,14 +9133,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -8457,6 +9164,7 @@ + @@ -8477,6 +9185,7 @@ + @@ -8497,6 +9206,7 @@ + @@ -8517,6 +9227,7 @@ + @@ -8537,6 +9248,7 @@ + @@ -8557,6 +9269,7 @@ + @@ -8577,6 +9290,7 @@ + @@ -8597,6 +9311,7 @@ + @@ -8617,6 +9332,7 @@ + @@ -8631,12 +9347,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -8657,6 +9379,7 @@ + @@ -8677,6 +9400,7 @@ + @@ -8697,6 +9421,7 @@ + @@ -8711,12 +9436,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -8731,12 +9462,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -8757,6 +9494,7 @@ + @@ -8777,6 +9515,7 @@ + @@ -8797,6 +9536,7 @@ + @@ -8817,6 +9557,7 @@ + @@ -8837,6 +9578,7 @@ + @@ -8857,6 +9599,7 @@ + @@ -8877,6 +9620,7 @@ + @@ -8897,6 +9641,7 @@ + @@ -8917,6 +9662,7 @@ + @@ -8937,6 +9683,7 @@ + @@ -8957,6 +9704,7 @@ + @@ -8977,6 +9725,7 @@ + @@ -8997,6 +9746,7 @@ + @@ -9017,6 +9767,7 @@ + @@ -9037,6 +9788,7 @@ + @@ -9051,12 +9803,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -9071,12 +9829,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -9091,12 +9855,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -9117,6 +9887,7 @@ + @@ -9137,6 +9908,7 @@ + @@ -9157,6 +9929,7 @@ + @@ -9177,6 +9950,7 @@ + @@ -9191,12 +9965,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -9231,7 +10011,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -9250,7 +10035,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -9275,6 +10065,7 @@ + @@ -9295,6 +10086,7 @@ + @@ -9315,6 +10107,7 @@ + @@ -9335,6 +10128,7 @@ + @@ -9355,6 +10149,7 @@ + @@ -9375,6 +10170,7 @@ + @@ -9395,6 +10191,7 @@ + @@ -9409,12 +10206,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -9429,12 +10232,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -9460,6 +10269,7 @@ + @@ -9480,6 +10290,7 @@ + @@ -9500,6 +10311,7 @@ + @@ -9520,6 +10332,7 @@ + @@ -9534,12 +10347,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -9560,6 +10379,7 @@ + @@ -9580,6 +10400,7 @@ + @@ -9600,6 +10421,7 @@ + @@ -9620,6 +10442,7 @@ + @@ -9640,6 +10463,7 @@ + @@ -9660,6 +10484,7 @@ + @@ -9680,6 +10505,7 @@ + @@ -9700,6 +10526,7 @@ + @@ -9720,6 +10547,7 @@ + @@ -9734,7 +10562,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -9753,13 +10586,19 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -9778,6 +10617,7 @@ + @@ -9798,6 +10638,7 @@ + @@ -9818,6 +10659,7 @@ + @@ -9838,6 +10680,7 @@ + @@ -9858,6 +10701,7 @@ + @@ -9872,12 +10716,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -9892,12 +10742,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -9912,12 +10768,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -9938,6 +10800,7 @@ + @@ -9958,6 +10821,7 @@ + @@ -9978,6 +10842,7 @@ + @@ -9998,6 +10863,7 @@ + @@ -10012,12 +10878,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -10038,6 +10910,7 @@ + @@ -10058,6 +10931,7 @@ + @@ -10078,6 +10952,7 @@ + @@ -10098,6 +10973,7 @@ + @@ -10118,6 +10994,7 @@ + @@ -10138,6 +11015,7 @@ + @@ -10158,6 +11036,7 @@ + @@ -10178,6 +11057,7 @@ + @@ -10198,6 +11078,7 @@ + @@ -10218,6 +11099,7 @@ + @@ -10238,6 +11120,7 @@ + @@ -10275,12 +11158,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -10295,12 +11184,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -10315,12 +11210,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -10341,6 +11242,7 @@ + @@ -10361,6 +11263,7 @@ + @@ -10381,6 +11284,7 @@ + @@ -10401,6 +11305,7 @@ + @@ -10421,6 +11326,7 @@ + @@ -10481,6 +11387,7 @@ + @@ -10501,6 +11408,7 @@ + @@ -10521,6 +11429,7 @@ + @@ -10541,6 +11450,7 @@ + @@ -10561,6 +11471,7 @@ + @@ -10606,6 +11517,7 @@ + @@ -10626,6 +11538,7 @@ + @@ -10646,6 +11559,7 @@ + @@ -10666,6 +11580,7 @@ + @@ -10686,6 +11601,7 @@ + @@ -10700,15 +11616,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

+ + + - + @@ -10726,6 +11648,7 @@ + @@ -10746,6 +11669,7 @@ + @@ -10766,6 +11690,7 @@ + @@ -10786,6 +11711,7 @@ + @@ -10806,6 +11732,7 @@ + @@ -10826,6 +11753,7 @@ + @@ -10846,6 +11774,7 @@ + @@ -10866,6 +11795,7 @@ + @@ -10886,6 +11816,7 @@ + @@ -10906,6 +11837,7 @@ + @@ -10926,6 +11858,7 @@ + @@ -10946,6 +11879,7 @@ + @@ -10966,6 +11900,7 @@ + @@ -10986,6 +11921,7 @@ + @@ -11006,6 +11942,7 @@ + @@ -11026,6 +11963,7 @@ + @@ -11046,6 +11984,7 @@ + @@ -11066,6 +12005,7 @@ + @@ -11086,6 +12026,7 @@ + @@ -11106,6 +12047,7 @@ + @@ -11126,6 +12068,7 @@ + @@ -11146,6 +12089,7 @@ + @@ -11166,6 +12110,7 @@ + @@ -11186,6 +12131,7 @@ + @@ -11206,6 +12152,7 @@ + @@ -11226,6 +12173,7 @@ + @@ -11240,12 +12188,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -11260,12 +12214,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -11280,12 +12240,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -11306,6 +12272,7 @@ + @@ -11326,6 +12293,7 @@ + @@ -11346,6 +12314,7 @@ + @@ -11366,6 +12335,7 @@ + @@ -11386,6 +12356,7 @@ + @@ -11406,6 +12377,7 @@ + @@ -11426,6 +12398,7 @@ + @@ -11440,12 +12413,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -11466,6 +12445,7 @@ + @@ -11486,6 +12466,7 @@ + @@ -11506,6 +12487,7 @@ + @@ -11526,6 +12508,7 @@ + @@ -11546,6 +12529,7 @@ + @@ -11566,6 +12550,7 @@ + @@ -11586,6 +12571,7 @@ + @@ -11600,12 +12586,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -11620,12 +12612,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -11646,6 +12644,7 @@ + @@ -11666,6 +12665,7 @@ + @@ -11686,6 +12686,7 @@ + @@ -11706,6 +12707,7 @@ + @@ -11726,6 +12728,7 @@ + @@ -11746,6 +12749,7 @@ + @@ -11766,6 +12770,7 @@ + @@ -11786,6 +12791,7 @@ + @@ -11800,12 +12806,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -11820,12 +12832,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -11846,6 +12864,7 @@ + @@ -11866,6 +12885,7 @@ + @@ -11886,6 +12906,7 @@ + @@ -11906,6 +12927,7 @@ + @@ -11926,6 +12948,7 @@ + @@ -11946,6 +12969,7 @@ + @@ -11966,6 +12990,7 @@ + @@ -11986,6 +13011,7 @@ + @@ -12006,6 +13032,7 @@ + @@ -12026,6 +13053,7 @@ + @@ -12046,6 +13074,7 @@ + @@ -12066,6 +13095,7 @@ + @@ -12086,6 +13116,7 @@ + @@ -12106,6 +13137,7 @@ + @@ -12126,6 +13158,7 @@ + @@ -12146,6 +13179,7 @@ + @@ -12166,6 +13200,7 @@ + @@ -12186,6 +13221,7 @@ + @@ -12206,6 +13242,7 @@ + @@ -12226,6 +13263,7 @@ + @@ -12246,6 +13284,7 @@ + @@ -12266,6 +13305,7 @@ + @@ -12286,6 +13326,7 @@ + @@ -12306,6 +13347,7 @@ + @@ -12320,12 +13362,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12340,12 +13388,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12360,7 +13414,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -12379,7 +13438,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -12398,12 +13462,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12418,12 +13488,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12437,12 +13513,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12456,12 +13538,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12475,12 +13563,19 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + @@ -12499,6 +13594,7 @@ + @@ -12519,6 +13615,7 @@ + @@ -12533,7 +13630,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -12552,12 +13654,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12572,12 +13680,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12592,12 +13706,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12612,12 +13732,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12633,6 +13759,11 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + @@ -12640,7 +13771,7 @@ - + @@ -12653,6 +13784,11 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + @@ -12660,7 +13796,7 @@ - + @@ -12678,6 +13814,7 @@ + @@ -12698,6 +13835,7 @@ + @@ -12718,6 +13856,7 @@ + @@ -12738,6 +13877,7 @@ + @@ -12758,6 +13898,7 @@ + @@ -12778,6 +13919,7 @@ + @@ -12798,6 +13940,7 @@ + @@ -12818,6 +13961,7 @@ + @@ -12832,7 +13976,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -12857,6 +14006,7 @@ + @@ -12871,12 +14021,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12891,12 +14047,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -12917,6 +14079,7 @@ + @@ -12937,6 +14100,7 @@ + @@ -12957,6 +14121,7 @@ + @@ -12977,6 +14142,7 @@ + @@ -12997,6 +14163,7 @@ + @@ -13017,6 +14184,7 @@ + @@ -13037,6 +14205,7 @@ + @@ -13057,6 +14226,7 @@ + @@ -13077,6 +14247,7 @@ + @@ -14285,6 +15456,7 @@ + @@ -14305,6 +15477,7 @@ + @@ -14325,6 +15498,7 @@ + @@ -14345,6 +15519,7 @@ + @@ -14365,6 +15540,7 @@ + @@ -14385,6 +15561,7 @@ + @@ -14405,6 +15582,7 @@ + @@ -14425,6 +15603,7 @@ + @@ -14445,6 +15624,7 @@ + @@ -14465,6 +15645,7 @@ + @@ -14485,6 +15666,7 @@ + @@ -14505,6 +15687,7 @@ + @@ -14524,6 +15707,7 @@ + @@ -14543,6 +15727,7 @@ + @@ -14562,6 +15747,7 @@ + @@ -14581,6 +15767,7 @@ + @@ -14600,6 +15787,7 @@ + @@ -14620,6 +15808,7 @@ + @@ -14640,6 +15829,7 @@ + @@ -14660,6 +15850,7 @@ + @@ -14680,6 +15871,7 @@ + @@ -14700,6 +15892,7 @@ + @@ -14720,6 +15913,7 @@ + @@ -14740,6 +15934,7 @@ + @@ -14760,6 +15955,7 @@ + @@ -14780,6 +15976,7 @@ + @@ -14800,6 +15997,7 @@ + @@ -14820,6 +16018,7 @@ + @@ -14840,6 +16039,7 @@ + @@ -14860,6 +16060,7 @@ + @@ -14880,6 +16081,7 @@ + @@ -14900,6 +16102,7 @@ + @@ -14920,6 +16123,7 @@ + @@ -14940,6 +16144,7 @@ + @@ -14954,12 +16159,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -14980,6 +16191,7 @@ + @@ -15000,6 +16212,7 @@ + @@ -15020,6 +16233,7 @@ + @@ -15040,6 +16254,7 @@ + @@ -15060,6 +16275,7 @@ + @@ -15080,6 +16296,7 @@ + @@ -15100,6 +16317,7 @@ + @@ -15120,6 +16338,7 @@ + @@ -15140,6 +16359,7 @@ + @@ -15160,6 +16380,7 @@ + @@ -15180,6 +16401,7 @@ + @@ -15200,6 +16422,7 @@ + @@ -15220,6 +16443,7 @@ + @@ -15240,6 +16464,7 @@ + @@ -15260,6 +16485,7 @@ + @@ -15280,6 +16506,7 @@ + @@ -15300,6 +16527,7 @@ + @@ -15320,6 +16548,7 @@ + @@ -15340,6 +16569,7 @@ + @@ -15360,6 +16590,7 @@ + @@ -15380,6 +16611,7 @@ + @@ -15400,6 +16632,7 @@ + @@ -15420,6 +16653,7 @@ + @@ -15440,6 +16674,7 @@ + @@ -15460,6 +16695,7 @@ + @@ -15480,6 +16716,7 @@ + @@ -15494,12 +16731,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -15520,6 +16763,7 @@ + @@ -15540,6 +16784,7 @@ + @@ -15560,6 +16805,7 @@ + @@ -15580,6 +16826,7 @@ + @@ -15600,6 +16847,7 @@ + @@ -15620,6 +16868,7 @@ + @@ -15640,6 +16889,7 @@ + @@ -15660,6 +16910,7 @@ + @@ -15680,6 +16931,7 @@ + @@ -15700,6 +16952,7 @@ + @@ -15720,6 +16973,7 @@ + @@ -15740,6 +16994,7 @@ + @@ -15760,6 +17015,7 @@ + @@ -15780,6 +17036,7 @@ + @@ -15800,6 +17057,7 @@ + @@ -15820,6 +17078,7 @@ + @@ -15840,6 +17099,7 @@ + @@ -15860,6 +17120,7 @@ + @@ -15880,6 +17141,7 @@ + @@ -15900,6 +17162,7 @@ + @@ -15920,6 +17183,7 @@ + @@ -15940,6 +17204,7 @@ + @@ -15960,6 +17225,7 @@ + @@ -15980,6 +17246,7 @@ + @@ -16000,6 +17267,7 @@ + @@ -16020,6 +17288,7 @@ + @@ -16040,6 +17309,7 @@ + @@ -16060,6 +17330,7 @@ + @@ -16080,6 +17351,7 @@ + @@ -16100,6 +17372,7 @@ + @@ -16120,6 +17393,7 @@ + @@ -16140,6 +17414,7 @@ + @@ -16160,6 +17435,7 @@ + @@ -16180,6 +17456,7 @@ + @@ -16200,6 +17477,7 @@ + @@ -16220,6 +17498,7 @@ + @@ -16240,6 +17519,7 @@ + @@ -16260,6 +17540,7 @@ + @@ -16280,6 +17561,7 @@ + @@ -16300,6 +17582,7 @@ + @@ -16320,6 +17603,7 @@ + @@ -16340,6 +17624,7 @@ + @@ -16360,6 +17645,7 @@ + @@ -16380,6 +17666,7 @@ + @@ -16400,6 +17687,7 @@ + @@ -16415,11 +17703,17 @@ + + +

NOTES: KEGG ID curated (PR #220)

+ + + @@ -16435,11 +17729,17 @@ + + +

NOTES: KEGG ID curated (PR #220)

+ + + @@ -16455,11 +17755,17 @@ + + +

NOTES: KEGG ID curated (PR #220)

+ + + @@ -16480,6 +17786,7 @@ + @@ -16500,6 +17807,7 @@ + @@ -16520,6 +17828,7 @@ + @@ -16540,6 +17849,7 @@ + @@ -16560,6 +17870,7 @@ + @@ -16580,6 +17891,7 @@ + @@ -16600,6 +17912,7 @@ + @@ -16620,6 +17933,7 @@ + @@ -16640,6 +17954,7 @@ + @@ -16660,6 +17975,7 @@ + @@ -16680,6 +17996,7 @@ + @@ -16700,6 +18017,7 @@ + @@ -16720,6 +18038,7 @@ + @@ -16740,6 +18059,7 @@ + @@ -16760,6 +18080,7 @@ + @@ -16780,6 +18101,7 @@ + @@ -16800,6 +18122,7 @@ + @@ -16820,6 +18143,7 @@ + @@ -16840,6 +18164,7 @@ + @@ -16860,6 +18185,7 @@ + @@ -16880,6 +18206,7 @@ + @@ -16900,6 +18227,7 @@ + @@ -16920,6 +18248,7 @@ + @@ -16940,6 +18269,7 @@ + @@ -16960,6 +18290,7 @@ + @@ -16980,6 +18311,7 @@ + @@ -17000,6 +18332,7 @@ + @@ -17020,6 +18353,7 @@ + @@ -17034,12 +18368,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -17054,12 +18394,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -17080,6 +18426,7 @@ + @@ -17100,6 +18447,7 @@ + @@ -17120,6 +18468,7 @@ + @@ -17140,6 +18489,7 @@ + @@ -17160,6 +18510,7 @@ + @@ -17200,6 +18551,7 @@ + @@ -17214,12 +18566,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -17234,12 +18592,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -17254,12 +18618,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -17280,6 +18650,7 @@ + @@ -17300,6 +18671,7 @@ + @@ -17320,6 +18692,7 @@ + @@ -17340,6 +18713,7 @@ + @@ -17354,12 +18728,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -17374,12 +18754,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -17400,6 +18786,7 @@ + @@ -17419,6 +18806,7 @@ + @@ -17438,6 +18826,7 @@ + @@ -17457,6 +18846,7 @@ + @@ -18064,15 +19454,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -18084,15 +19480,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -18110,6 +19512,7 @@ + @@ -18130,6 +19533,7 @@ + @@ -18150,6 +19554,7 @@ + @@ -18170,6 +19575,7 @@ + @@ -18190,6 +19596,7 @@ + @@ -18210,6 +19617,7 @@ + @@ -18230,6 +19638,7 @@ + @@ -18250,6 +19659,7 @@ + @@ -18270,6 +19680,7 @@ + @@ -18290,6 +19701,7 @@ + @@ -18310,6 +19722,7 @@ + @@ -18330,6 +19743,7 @@ + @@ -18350,6 +19764,7 @@ + @@ -18370,6 +19785,7 @@ + @@ -18390,6 +19806,7 @@ + @@ -18410,6 +19827,7 @@ + @@ -18425,14 +19843,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -18444,12 +19868,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -18464,14 +19894,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + - + @@ -18483,14 +19918,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + - + @@ -18508,6 +19948,7 @@ + @@ -18528,6 +19969,7 @@ + @@ -18542,12 +19984,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -18568,6 +20016,7 @@ + @@ -18588,6 +20037,7 @@ + @@ -18608,6 +20058,7 @@ + @@ -18628,6 +20079,7 @@ + @@ -18648,6 +20100,7 @@ + @@ -18668,6 +20121,7 @@ + @@ -18682,12 +20136,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -18707,6 +20167,7 @@ + @@ -18727,6 +20188,7 @@ + @@ -18747,6 +20209,7 @@ + @@ -18767,6 +20230,7 @@ + @@ -18787,6 +20251,7 @@ + @@ -18807,6 +20272,7 @@ + @@ -18827,6 +20293,7 @@ + @@ -18847,6 +20314,7 @@ + @@ -18867,6 +20335,7 @@ + @@ -18887,6 +20356,7 @@ + @@ -18907,6 +20377,7 @@ + @@ -18927,6 +20398,7 @@ + @@ -18947,6 +20419,7 @@ + @@ -18967,6 +20440,7 @@ + @@ -18987,6 +20461,7 @@ + @@ -19007,6 +20482,7 @@ + @@ -19027,6 +20503,7 @@ + @@ -19047,6 +20524,7 @@ + @@ -19067,6 +20545,7 @@ + @@ -19087,6 +20566,7 @@ + @@ -19107,6 +20587,7 @@ + @@ -19127,6 +20608,7 @@ + @@ -19147,6 +20629,7 @@ + @@ -19167,6 +20650,7 @@ + @@ -19187,6 +20671,7 @@ + @@ -19207,6 +20692,7 @@ + @@ -19227,6 +20713,7 @@ + @@ -19247,6 +20734,7 @@ + @@ -19267,6 +20755,7 @@ + @@ -19281,7 +20770,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -19300,7 +20794,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -19320,7 +20819,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -19340,7 +20844,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -19366,6 +20875,7 @@ + @@ -19386,6 +20896,7 @@ + @@ -19406,6 +20917,7 @@ + @@ -19426,6 +20938,7 @@ + @@ -19446,6 +20959,7 @@ + @@ -19466,6 +20980,7 @@ + @@ -19486,6 +21001,7 @@ + @@ -19506,6 +21022,7 @@ + @@ -19526,6 +21043,7 @@ + @@ -19540,7 +21058,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -19565,6 +21088,7 @@ + @@ -19585,6 +21109,7 @@ + @@ -19605,6 +21130,7 @@ + @@ -19645,6 +21171,7 @@ + @@ -19659,12 +21186,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -19685,6 +21218,7 @@ + @@ -19705,6 +21239,7 @@ + @@ -19725,6 +21260,7 @@ + @@ -19745,6 +21281,7 @@ + @@ -19765,6 +21302,7 @@ + @@ -19785,6 +21323,7 @@ + @@ -19805,6 +21344,7 @@ + @@ -19825,6 +21365,7 @@ + @@ -19845,6 +21386,7 @@ + @@ -19865,6 +21407,7 @@ + @@ -19885,6 +21428,7 @@ + @@ -19905,6 +21449,7 @@ + @@ -19925,6 +21470,7 @@ + @@ -19945,6 +21491,7 @@ + @@ -19965,6 +21512,7 @@ + @@ -19985,6 +21533,7 @@ + @@ -20005,6 +21554,7 @@ + @@ -20025,6 +21575,7 @@ + @@ -20045,6 +21596,7 @@ + @@ -20059,12 +21611,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -20084,6 +21642,7 @@ + @@ -20104,6 +21663,7 @@ + @@ -20124,6 +21684,7 @@ + @@ -20144,6 +21705,7 @@ + @@ -20164,6 +21726,7 @@ + @@ -20184,6 +21747,7 @@ + @@ -20204,6 +21768,7 @@ + @@ -20224,6 +21789,7 @@ + @@ -20244,6 +21810,7 @@ + @@ -20264,6 +21831,7 @@ + @@ -20284,6 +21852,7 @@ + @@ -20298,12 +21867,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -20318,7 +21893,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -20337,12 +21917,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -20357,12 +21943,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -20377,12 +21969,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -20397,12 +21995,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -20417,12 +22021,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -20443,6 +22053,7 @@ + @@ -20463,6 +22074,7 @@ + @@ -20483,6 +22095,7 @@ + @@ -20503,6 +22116,7 @@ + @@ -20523,6 +22137,7 @@ + @@ -20543,6 +22158,7 @@ + @@ -20563,6 +22179,7 @@ + @@ -20583,6 +22200,7 @@ + @@ -20603,6 +22221,7 @@ + @@ -20623,6 +22242,7 @@ + @@ -20643,6 +22263,7 @@ + @@ -20663,6 +22284,7 @@ + @@ -20688,6 +22310,7 @@ + @@ -20713,6 +22336,7 @@ + @@ -20738,6 +22362,7 @@ + @@ -20763,6 +22388,7 @@ + @@ -20783,6 +22409,7 @@ + @@ -20803,6 +22430,7 @@ + @@ -20817,12 +22445,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -20843,6 +22477,7 @@ + @@ -20857,12 +22492,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -20877,12 +22518,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -20902,6 +22549,7 @@ + @@ -20942,6 +22590,7 @@ + @@ -20962,6 +22611,7 @@ + @@ -20982,6 +22632,7 @@ + @@ -21002,6 +22653,7 @@ + @@ -21022,6 +22674,7 @@ + @@ -21042,6 +22695,7 @@ + @@ -21062,6 +22716,7 @@ + @@ -21076,12 +22731,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -21102,6 +22763,7 @@ + @@ -21122,6 +22784,7 @@ + @@ -21142,6 +22805,7 @@ + @@ -21162,6 +22826,7 @@ + @@ -21182,6 +22847,7 @@ + @@ -21202,6 +22868,7 @@ + @@ -21242,6 +22909,7 @@ + @@ -21262,6 +22930,7 @@ + @@ -21282,6 +22951,7 @@ + @@ -21302,6 +22972,7 @@ + @@ -21322,6 +22993,7 @@ + @@ -21342,6 +23014,7 @@ + @@ -21362,6 +23035,7 @@ + @@ -21382,6 +23056,7 @@ + @@ -21402,6 +23077,7 @@ + @@ -21422,6 +23098,7 @@ + @@ -21442,6 +23119,7 @@ + @@ -21462,6 +23140,7 @@ + @@ -21482,6 +23161,7 @@ + @@ -21502,6 +23182,7 @@ + @@ -21522,6 +23203,7 @@ + @@ -21542,6 +23224,7 @@ + @@ -21562,6 +23245,7 @@ + @@ -21582,6 +23266,7 @@ + @@ -21596,12 +23281,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -21616,12 +23307,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -21635,12 +23332,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -21655,12 +23358,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -21681,6 +23390,7 @@ + @@ -21701,6 +23411,7 @@ + @@ -21721,6 +23432,7 @@ + @@ -21741,6 +23453,7 @@ + @@ -21761,6 +23474,7 @@ + @@ -21781,6 +23495,7 @@ + @@ -21801,6 +23516,7 @@ + @@ -21821,6 +23537,7 @@ + @@ -21841,6 +23558,7 @@ + @@ -21861,6 +23579,7 @@ + @@ -21881,6 +23600,7 @@ + @@ -21901,6 +23621,7 @@ + @@ -21921,6 +23642,7 @@ + @@ -21941,6 +23663,7 @@ + @@ -21955,12 +23678,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -21981,6 +23710,7 @@ + @@ -22001,6 +23731,7 @@ + @@ -22021,6 +23752,7 @@ + @@ -22041,6 +23773,7 @@ + @@ -22061,6 +23794,7 @@ + @@ -22081,6 +23815,7 @@ + @@ -22101,6 +23836,7 @@ + @@ -22121,6 +23857,7 @@ + @@ -22141,6 +23878,7 @@ + @@ -22161,6 +23899,7 @@ + @@ -22181,6 +23920,7 @@ + @@ -22201,6 +23941,7 @@ + @@ -22221,6 +23962,7 @@ + @@ -22241,6 +23983,7 @@ + @@ -22261,6 +24004,7 @@ + @@ -22281,6 +24025,7 @@ + @@ -22301,6 +24046,7 @@ + @@ -22321,6 +24067,7 @@ + @@ -22341,6 +24088,7 @@ + @@ -22361,6 +24109,7 @@ + @@ -22381,6 +24130,7 @@ + @@ -22401,6 +24151,7 @@ + @@ -22421,6 +24172,7 @@ + @@ -22441,6 +24193,7 @@ + @@ -22461,6 +24214,7 @@ + @@ -22481,6 +24235,7 @@ + @@ -22501,6 +24256,7 @@ + @@ -22521,6 +24277,7 @@ + @@ -22541,6 +24298,7 @@ + @@ -22561,6 +24319,7 @@ + @@ -22581,6 +24340,7 @@ + @@ -22595,12 +24355,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22615,12 +24381,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22641,6 +24413,7 @@ + @@ -22661,6 +24434,7 @@ + @@ -22681,6 +24455,7 @@ + @@ -22701,6 +24476,7 @@ + @@ -22715,12 +24491,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22735,12 +24517,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22755,12 +24543,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22775,12 +24569,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22795,12 +24595,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22815,12 +24621,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22835,7 +24647,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -22860,6 +24677,7 @@ + @@ -22874,12 +24692,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22894,12 +24718,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22920,6 +24750,7 @@ + @@ -22940,6 +24771,7 @@ + @@ -22954,12 +24786,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -22974,12 +24812,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23000,6 +24844,7 @@ + @@ -23020,6 +24865,7 @@ + @@ -23034,12 +24880,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23054,12 +24906,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23080,6 +24938,7 @@ + @@ -23100,6 +24959,7 @@ + @@ -23115,11 +24975,18 @@ + + +

NOTES: ChEBI curated (PR #220)

+ + + + @@ -23134,11 +25001,18 @@ + + +

NOTES: ChEBI curated (PR #220)

+ + + + @@ -23152,12 +25026,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23171,12 +25051,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23197,6 +25083,7 @@ + @@ -23217,6 +25104,7 @@ + @@ -23237,6 +25125,7 @@ + @@ -23257,6 +25146,7 @@ + @@ -23271,7 +25161,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -23301,6 +25196,7 @@ + @@ -23335,12 +25231,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23355,12 +25257,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23381,6 +25289,7 @@ + @@ -23401,6 +25310,7 @@ + @@ -23421,6 +25331,7 @@ + @@ -23441,6 +25352,7 @@ + @@ -23455,12 +25367,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23475,12 +25393,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23521,6 +25445,7 @@ + @@ -23541,6 +25466,7 @@ + @@ -23561,6 +25487,7 @@ + @@ -23581,6 +25508,7 @@ + @@ -23601,6 +25529,7 @@ + @@ -23621,6 +25550,7 @@ + @@ -23636,14 +25566,20 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + - + @@ -23661,6 +25597,7 @@ + @@ -23681,6 +25618,7 @@ + @@ -23701,6 +25639,7 @@ + @@ -23721,6 +25660,7 @@ + @@ -23741,6 +25681,7 @@ + @@ -23755,12 +25696,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23781,6 +25728,7 @@ + @@ -23801,6 +25749,7 @@ + @@ -23821,6 +25770,7 @@ + @@ -23841,6 +25791,7 @@ + @@ -23861,6 +25812,7 @@ + @@ -23875,12 +25827,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -23901,6 +25859,7 @@ + @@ -23921,6 +25880,7 @@ + @@ -23941,6 +25901,7 @@ + @@ -23961,6 +25922,7 @@ + @@ -23981,6 +25943,7 @@ + @@ -23995,12 +25958,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -24015,12 +25984,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -24041,6 +26016,7 @@ + @@ -24061,6 +26037,7 @@ + @@ -24081,6 +26058,7 @@ + @@ -24101,6 +26079,7 @@ + @@ -24121,6 +26100,7 @@ + @@ -24141,6 +26121,7 @@ + @@ -24161,6 +26142,7 @@ + @@ -24181,6 +26163,7 @@ + @@ -24201,6 +26184,7 @@ + @@ -24221,6 +26205,7 @@ + @@ -24240,6 +26225,7 @@ + @@ -24253,7 +26239,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -24278,6 +26269,7 @@ + @@ -24291,12 +26283,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -24311,12 +26309,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24331,12 +26335,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24351,12 +26361,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24371,12 +26387,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24391,12 +26413,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24411,12 +26439,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24431,12 +26465,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -24451,12 +26491,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -24471,12 +26517,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24491,12 +26543,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24511,12 +26569,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -24531,12 +26595,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24551,12 +26621,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24571,12 +26647,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24591,12 +26673,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24611,12 +26699,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24631,12 +26725,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24651,12 +26751,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24671,12 +26777,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24691,12 +26803,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24711,12 +26829,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24731,12 +26855,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24751,12 +26881,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24771,12 +26907,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -24791,12 +26933,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -24811,12 +26959,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24831,12 +26985,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24851,12 +27011,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24871,12 +27037,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24891,12 +27063,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24911,12 +27089,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24931,12 +27115,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24951,12 +27141,18 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + + @@ -24971,15 +27167,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + - + @@ -24991,15 +27193,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + - + @@ -25011,15 +27219,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + - + @@ -25031,15 +27245,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + - + @@ -25051,12 +27271,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25071,12 +27297,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25091,12 +27323,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25111,12 +27349,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25131,12 +27375,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25177,6 +27427,7 @@ + @@ -25197,6 +27448,7 @@ + @@ -25217,6 +27469,7 @@ + @@ -25237,6 +27490,7 @@ + @@ -25277,6 +27531,7 @@ + @@ -25317,6 +27572,7 @@ + @@ -25337,6 +27593,7 @@ + @@ -25355,6 +27612,7 @@ + @@ -25369,14 +27627,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

+ + + + @@ -25388,7 +27653,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -25412,6 +27682,7 @@ + @@ -25427,12 +27698,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -25450,6 +27728,7 @@ + @@ -25470,6 +27749,7 @@ + @@ -25490,6 +27770,7 @@ + @@ -25510,6 +27791,7 @@ + @@ -25530,6 +27812,7 @@ + @@ -25544,12 +27827,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25570,6 +27859,7 @@ + @@ -25590,6 +27880,7 @@ + @@ -25610,6 +27901,7 @@ + @@ -25624,12 +27916,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25650,6 +27948,7 @@ + @@ -25664,12 +27963,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25683,12 +27988,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25703,12 +28014,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25722,12 +28039,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25742,12 +28065,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25761,12 +28090,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25781,12 +28116,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25806,6 +28147,7 @@ + @@ -25826,6 +28168,7 @@ + @@ -25840,12 +28183,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25860,12 +28209,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25880,12 +28235,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25900,12 +28261,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25919,12 +28286,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -25938,14 +28311,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + - + @@ -25957,7 +28336,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -25982,6 +28366,7 @@ + @@ -26002,6 +28387,7 @@ + @@ -26016,13 +28402,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + @@ -26034,12 +28427,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -26054,10 +28453,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + @@ -26067,10 +28476,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + @@ -26080,13 +28499,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXM165192 (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + @@ -26098,12 +28524,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -26117,12 +28549,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -26142,6 +28580,7 @@ + @@ -26162,6 +28601,7 @@ + @@ -26182,6 +28622,7 @@ + @@ -26202,6 +28643,7 @@ + @@ -26222,6 +28664,7 @@ + @@ -26242,6 +28685,7 @@ + @@ -26262,6 +28706,7 @@ + @@ -26282,6 +28727,7 @@ + @@ -26302,6 +28748,7 @@ + @@ -26322,6 +28769,7 @@ + @@ -26342,6 +28790,7 @@ + @@ -26362,6 +28811,7 @@ + @@ -26382,6 +28832,7 @@ + @@ -26402,6 +28853,7 @@ + @@ -26422,6 +28874,7 @@ + @@ -26442,6 +28895,7 @@ + @@ -26462,6 +28916,7 @@ + @@ -26482,6 +28937,7 @@ + @@ -26502,6 +28958,7 @@ + @@ -26522,6 +28979,7 @@ + @@ -26542,6 +29000,7 @@ + @@ -26562,6 +29021,7 @@ + @@ -26582,6 +29042,7 @@ + @@ -26602,6 +29063,7 @@ + @@ -26622,6 +29084,7 @@ + @@ -26642,6 +29105,7 @@ + @@ -26662,6 +29126,7 @@ + @@ -26682,6 +29147,7 @@ + @@ -26702,6 +29168,7 @@ + @@ -26722,6 +29189,7 @@ + @@ -26742,6 +29210,7 @@ + @@ -26762,6 +29231,7 @@ + @@ -26782,6 +29252,7 @@ + @@ -26802,6 +29273,7 @@ + @@ -26822,6 +29294,7 @@ + @@ -26842,6 +29315,7 @@ + @@ -26862,6 +29336,7 @@ + @@ -26882,7 +29357,10 @@ + + + @@ -26900,6 +29378,7 @@ + @@ -26920,6 +29399,7 @@ + @@ -26934,12 +29414,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -26960,6 +29446,7 @@ + @@ -26974,12 +29461,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27000,6 +29493,7 @@ + @@ -27014,12 +29508,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27040,6 +29540,7 @@ + @@ -27053,12 +29554,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27078,6 +29585,7 @@ + @@ -27098,6 +29606,7 @@ + @@ -27118,6 +29627,7 @@ + @@ -27137,6 +29647,7 @@ + @@ -27151,12 +29662,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27177,6 +29694,7 @@ + @@ -27191,12 +29709,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27217,6 +29741,7 @@ + @@ -27230,12 +29755,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27255,6 +29786,7 @@ + @@ -27269,12 +29801,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27289,12 +29827,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27309,12 +29853,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27329,12 +29879,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27355,6 +29911,7 @@ + @@ -27375,6 +29932,7 @@ + @@ -27395,6 +29953,7 @@ + @@ -27415,6 +29974,7 @@ + @@ -27435,6 +29995,7 @@ + @@ -27455,6 +30016,7 @@ + @@ -27469,12 +30031,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27489,10 +30057,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + @@ -27502,10 +30080,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + @@ -27515,13 +30103,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXM165192 (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + @@ -27534,12 +30129,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + @@ -27595,7 +30196,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -27608,12 +30214,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27629,12 +30241,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -27665,12 +30283,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -27695,7 +30319,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -27721,6 +30350,7 @@ + @@ -27739,6 +30369,7 @@ + @@ -27753,13 +30384,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27778,6 +30415,7 @@ + @@ -27789,13 +30427,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27807,7 +30451,12 @@ - + + + +

alternative ChEBI CHEBI:88087 (PR #220) | metFormula curated (PR #222)

+ + @@ -27820,7 +30469,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -27833,7 +30487,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -27847,12 +30506,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27906,6 +30571,7 @@ + @@ -27926,6 +30592,7 @@ + @@ -27946,6 +30613,7 @@ + @@ -27960,12 +30628,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27979,12 +30653,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -27998,12 +30678,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -28017,7 +30703,12 @@ - + + + +

alternative ChEBI CHEBI:88090 (PR #220) | metFormula curated (PR #222)

+ + @@ -28035,7 +30726,12 @@ - + + + +

alternative ChEBI CHEBI:88080 (PR #220) | metFormula curated (PR #222)

+ + @@ -28048,7 +30744,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -28061,7 +30762,12 @@ - + + + +

alternative ChEBI CHEBI:76896 (PR #220) | metFormula curated (PR #222)

+ + @@ -28079,10 +30785,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + + @@ -28092,10 +30809,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + + @@ -28106,9 +30834,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -28119,12 +30857,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -28158,6 +30903,11 @@ + + + + + @@ -28168,12 +30918,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28186,12 +30942,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28223,13 +30985,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

+ + + @@ -28247,6 +31015,7 @@ + @@ -28267,6 +31036,7 @@ + @@ -28282,12 +31052,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28300,12 +31076,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -28318,12 +31101,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28341,6 +31130,7 @@ + @@ -28375,15 +31165,15 @@ - + + + +

ChEBI curated (PR #220) | alternative ChEBI CHEBI:74694 (PR #220) | metCharge curated (PR #222)

+ + - - - - - @@ -28393,7 +31183,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -28413,7 +31208,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -28439,6 +31239,7 @@ + @@ -28454,12 +31255,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28472,12 +31279,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -28490,12 +31304,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28527,15 +31347,15 @@ - + + + +

ChEBI curated (PR #220) | alternative ChEBI CHEBI:74694 (PR #220) | metCharge curated (PR #222)

+ + - - - - - @@ -28545,7 +31365,12 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -28565,7 +31390,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -28591,6 +31421,7 @@ + @@ -28611,6 +31442,7 @@ + @@ -28625,13 +31457,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -28644,6 +31482,11 @@ + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -28664,12 +31507,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -28682,9 +31532,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -28695,12 +31555,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28713,12 +31579,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28731,12 +31603,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28749,12 +31627,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28767,6 +31651,11 @@ + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -28787,9 +31676,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -28800,12 +31699,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28818,12 +31723,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28841,6 +31752,7 @@ + @@ -28855,13 +31767,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -28880,6 +31798,7 @@ + @@ -28892,12 +31811,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -28910,12 +31836,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28928,12 +31860,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28946,12 +31884,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28964,12 +31908,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -28982,12 +31932,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -28999,13 +31956,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -29023,6 +31986,7 @@ + @@ -29043,6 +32007,7 @@ + @@ -29057,13 +32022,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -29076,6 +32047,11 @@ + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -29102,6 +32078,7 @@ + @@ -29114,12 +32091,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -29132,12 +32116,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -29150,9 +32141,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -29163,12 +32164,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29181,12 +32188,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29199,12 +32212,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29217,12 +32236,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29235,12 +32260,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29253,12 +32284,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29271,12 +32308,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29289,12 +32332,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29307,12 +32356,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -29324,13 +32380,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -29348,6 +32410,7 @@ + @@ -29368,6 +32431,7 @@ + @@ -29382,13 +32446,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -29401,6 +32471,11 @@ + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -29427,6 +32502,7 @@ + @@ -29439,12 +32515,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -29457,12 +32540,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -29475,9 +32565,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -29488,12 +32588,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29506,12 +32612,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29524,12 +32636,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29542,12 +32660,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29560,12 +32684,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29578,12 +32708,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29596,12 +32732,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29614,12 +32756,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -29632,12 +32780,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -29656,6 +32811,7 @@ + @@ -29674,6 +32830,7 @@ + @@ -29689,6 +32846,11 @@ + + + + + @@ -29731,6 +32893,7 @@ + @@ -29762,6 +32925,7 @@ + @@ -29780,6 +32944,7 @@ + @@ -29810,7 +32975,9 @@ + + @@ -29842,6 +33009,7 @@ + @@ -29870,6 +33038,11 @@ + + + + + @@ -29899,6 +33072,7 @@ + @@ -29917,6 +33091,7 @@ + @@ -29961,6 +33136,7 @@ + @@ -30048,7 +33224,9 @@ + + @@ -30067,6 +33245,7 @@ + @@ -30110,7 +33289,9 @@ + + @@ -30129,6 +33310,7 @@ + @@ -30140,13 +33322,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -30165,6 +33353,7 @@ + @@ -30183,6 +33372,7 @@ + @@ -30201,6 +33391,7 @@ + @@ -30213,12 +33404,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -30234,6 +33432,11 @@ + + + + + @@ -30244,12 +33447,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -30275,12 +33484,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -30306,12 +33521,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -30330,6 +33551,7 @@ + @@ -30342,12 +33564,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -30373,12 +33601,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -30397,6 +33632,7 @@ + @@ -30415,6 +33651,7 @@ + @@ -30445,7 +33682,9 @@ + + @@ -30477,6 +33716,7 @@ + @@ -30505,6 +33745,11 @@ + + + + + @@ -30534,6 +33779,7 @@ + @@ -30552,6 +33798,7 @@ + @@ -30596,6 +33843,7 @@ + @@ -30683,7 +33931,9 @@ + + @@ -30702,6 +33952,7 @@ + @@ -30745,7 +33996,9 @@ + + @@ -30764,6 +34017,7 @@ + @@ -30781,6 +34035,7 @@ + @@ -30809,12 +34064,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -30853,6 +34114,11 @@ + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -30885,7 +34151,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -30916,13 +34187,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -30940,6 +34217,7 @@ + @@ -30960,6 +34238,7 @@ + @@ -30980,6 +34259,7 @@ + @@ -31008,12 +34288,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -31026,12 +34313,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31044,12 +34337,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31075,12 +34374,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31106,6 +34411,11 @@ + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -31126,6 +34436,11 @@ + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -31146,9 +34461,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -31177,6 +34502,7 @@ + @@ -31197,6 +34523,7 @@ + @@ -31212,12 +34539,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31230,9 +34563,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -31243,12 +34586,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31261,12 +34610,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31279,12 +34634,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + + @@ -31297,12 +34659,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31315,12 +34683,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + @@ -31333,12 +34707,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31356,6 +34736,7 @@ + @@ -31371,12 +34752,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31392,6 +34779,11 @@ + + + + + @@ -31402,12 +34794,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31438,6 +34836,11 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + @@ -31445,6 +34848,7 @@ + @@ -31475,12 +34879,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31510,10 +34920,20 @@ - + + + +

NOTES: ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + @@ -31523,7 +34943,12 @@ - + + + +

alternative ChEBI CHEBI:90456 (PR #220) | metFormula curated (PR #222)

+ + @@ -31537,12 +34962,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31560,6 +34991,7 @@ + @@ -31593,9 +35025,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -31611,6 +35053,7 @@ + @@ -31624,12 +35067,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31660,12 +35109,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31684,6 +35139,7 @@ + @@ -31696,12 +35152,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + + @@ -31732,12 +35195,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31768,12 +35237,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + @@ -31804,12 +35279,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31840,12 +35321,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31863,6 +35350,7 @@ + @@ -31883,6 +35371,7 @@ + @@ -31916,9 +35405,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -31934,6 +35433,7 @@ + @@ -31947,12 +35447,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -31983,12 +35489,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -32007,6 +35519,7 @@ + @@ -32019,12 +35532,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + + @@ -32055,12 +35575,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -32091,12 +35617,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + @@ -32127,12 +35659,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -32163,12 +35701,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -32186,6 +35730,7 @@ + @@ -32206,6 +35751,7 @@ + @@ -32239,9 +35785,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -32257,6 +35813,7 @@ + @@ -32270,12 +35827,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -32306,12 +35869,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -32330,6 +35899,7 @@ + @@ -32342,12 +35912,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + + @@ -32378,12 +35955,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -32414,12 +35997,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + @@ -32450,12 +36039,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -32509,6 +36104,7 @@ + @@ -32529,6 +36125,7 @@ + @@ -32562,6 +36159,7 @@ + @@ -32625,6 +36223,7 @@ + @@ -32767,6 +36366,7 @@ + @@ -32876,6 +36476,7 @@ + @@ -32906,12 +36507,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + + @@ -32923,13 +36531,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -32941,13 +36555,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -32978,12 +36598,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + @@ -32995,13 +36621,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -33013,13 +36645,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -33037,6 +36675,7 @@ + @@ -33057,6 +36696,7 @@ + @@ -33071,12 +36711,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -33097,6 +36743,7 @@ + @@ -33117,6 +36764,7 @@ + @@ -33131,7 +36779,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33144,7 +36797,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33157,7 +36815,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33170,7 +36833,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33183,10 +36851,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + @@ -33196,7 +36874,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33215,6 +36898,7 @@ + @@ -33253,6 +36937,7 @@ + @@ -33353,10 +37038,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + @@ -33367,9 +37062,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -33379,10 +37084,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + @@ -33393,9 +37108,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -33405,10 +37130,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + @@ -33419,9 +37154,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -33431,7 +37176,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33445,12 +37195,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXM121235 (PR #220)

+ + + + @@ -33462,7 +37219,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33476,9 +37238,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -33488,7 +37260,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33502,9 +37279,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -33514,7 +37301,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33540,7 +37332,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33566,7 +37363,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33592,7 +37394,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33618,7 +37425,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33644,7 +37456,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33670,7 +37487,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33684,9 +37506,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -33696,7 +37528,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33710,9 +37547,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -33722,7 +37569,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33736,9 +37588,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -33748,7 +37610,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33774,7 +37641,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33800,7 +37672,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -33845,6 +37722,7 @@ + @@ -33930,6 +37808,7 @@ + @@ -34196,10 +38075,23 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + + @@ -34210,12 +38102,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + + @@ -34227,10 +38126,22 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + @@ -34240,13 +38151,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -34258,10 +38175,22 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + @@ -34271,13 +38200,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -34289,10 +38224,23 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + + @@ -34321,12 +38269,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + @@ -34338,13 +38292,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -34356,13 +38316,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -34374,7 +38340,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -34400,7 +38371,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -34426,7 +38402,12 @@ - + + + +

NOTES: metFormula curated (PR #222)

+ + @@ -34536,6 +38517,7 @@ + @@ -34556,6 +38538,7 @@ + @@ -34576,6 +38559,7 @@ + @@ -34591,12 +38575,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -34614,6 +38604,7 @@ + @@ -34645,6 +38636,11 @@ + + + + + @@ -34658,6 +38654,11 @@ + + + + + @@ -34668,12 +38669,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -34730,6 +38737,11 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + @@ -34737,6 +38749,7 @@ + @@ -34793,12 +38806,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -34860,12 +38879,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -34883,6 +38908,7 @@ + @@ -34903,6 +38929,7 @@ + @@ -34934,6 +38961,11 @@ + + + + + @@ -34947,6 +38979,11 @@ + + + + + @@ -34957,12 +38994,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -35019,6 +39062,11 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + @@ -35026,6 +39074,7 @@ + @@ -35082,12 +39131,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -35149,12 +39204,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -35172,6 +39233,7 @@ + @@ -35192,6 +39254,7 @@ + @@ -35223,6 +39286,11 @@ + + + + + @@ -35236,6 +39304,11 @@ + + + + + @@ -35246,12 +39319,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -35308,6 +39387,11 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + @@ -35315,6 +39399,7 @@ + @@ -35371,12 +39456,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -35438,12 +39529,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -35472,6 +39569,11 @@ + + + + + @@ -35485,6 +39587,11 @@ + + + + + @@ -35495,12 +39602,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -35557,6 +39670,11 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + @@ -35564,6 +39682,7 @@ + @@ -35620,12 +39739,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -35703,6 +39828,11 @@ + + + + + @@ -36128,6 +40258,7 @@ + @@ -36144,6 +40275,11 @@ + + + + + @@ -36159,6 +40295,7 @@ + @@ -36177,6 +40314,7 @@ + @@ -36189,10 +40327,23 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + + @@ -36202,10 +40353,22 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + @@ -36215,10 +40378,22 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + @@ -36228,10 +40403,23 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + + @@ -36247,6 +40435,7 @@ + @@ -36305,6 +40494,7 @@ + @@ -36363,6 +40553,7 @@ + @@ -36421,6 +40612,7 @@ + @@ -36479,6 +40671,7 @@ + @@ -36537,6 +40730,7 @@ + @@ -36575,6 +40769,7 @@ + @@ -36589,10 +40784,23 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + + @@ -36608,6 +40816,7 @@ + @@ -36623,12 +40832,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + + @@ -36640,10 +40856,22 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + @@ -36653,13 +40881,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -36671,10 +40905,22 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + @@ -36684,13 +40930,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -36702,10 +40954,23 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + + @@ -36739,6 +41004,7 @@ + @@ -36754,12 +41020,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + @@ -36771,13 +41043,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -36789,13 +41067,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -36813,6 +41097,7 @@ + @@ -36833,6 +41118,7 @@ + @@ -36871,6 +41157,7 @@ + @@ -36889,6 +41176,7 @@ + @@ -36905,6 +41193,11 @@ + + + + + @@ -36938,6 +41231,7 @@ + @@ -36957,6 +41251,7 @@ + @@ -36974,6 +41269,7 @@ + @@ -37064,6 +41360,7 @@ + @@ -37079,12 +41376,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37096,10 +41399,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + @@ -37110,9 +41423,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -37122,10 +41445,20 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + @@ -37136,12 +41469,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37153,10 +41492,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + + @@ -37167,12 +41517,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37184,10 +41540,21 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + + + + + + + @@ -37198,12 +41565,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + + @@ -37216,12 +41590,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37234,12 +41614,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + @@ -37252,12 +41638,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37275,6 +41667,7 @@ + @@ -37293,6 +41686,7 @@ + @@ -37329,6 +41723,7 @@ + @@ -37365,6 +41760,7 @@ + @@ -37392,13 +41788,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -37416,6 +41818,7 @@ + @@ -37444,12 +41847,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -37475,12 +41885,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37506,12 +41922,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37543,6 +41965,7 @@ + @@ -37568,12 +41991,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37604,12 +42033,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37635,12 +42070,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -37652,13 +42094,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -37671,12 +42119,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -37689,12 +42144,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37707,12 +42168,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37731,6 +42198,7 @@ + @@ -37743,12 +42211,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37761,12 +42235,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37779,12 +42259,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -37796,13 +42283,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -37815,12 +42308,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -37833,12 +42333,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37851,12 +42357,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37875,6 +42387,7 @@ + @@ -37887,12 +42400,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37904,13 +42423,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -37923,12 +42448,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -37941,12 +42473,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37959,12 +42497,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -37977,6 +42521,11 @@ + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + @@ -37997,9 +42546,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + + + + @@ -38010,12 +42569,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -38028,12 +42593,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -38064,6 +42635,7 @@ + @@ -38082,6 +42654,11 @@ + + + + + @@ -38193,12 +42770,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -38214,6 +42797,11 @@ + + + + + @@ -38227,6 +42815,11 @@ + + + + + @@ -38250,12 +42843,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -38312,6 +42911,11 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + @@ -38319,6 +42923,7 @@ + @@ -38380,12 +42985,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -38450,6 +43061,11 @@ + + + + + @@ -38564,6 +43180,11 @@ + + + + + @@ -38678,6 +43299,11 @@ + + + + + @@ -38787,6 +43413,11 @@ + + + + + @@ -39422,6 +44053,7 @@ + @@ -39442,6 +44074,7 @@ + @@ -39455,12 +44088,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -39491,12 +44130,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -39514,6 +44160,7 @@ + @@ -39527,12 +44174,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -39550,6 +44203,7 @@ + @@ -39568,6 +44222,7 @@ + @@ -39588,6 +44243,7 @@ + @@ -39601,12 +44257,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -39637,12 +44299,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -39660,6 +44329,7 @@ + @@ -39673,12 +44343,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -39696,6 +44372,7 @@ + @@ -39714,6 +44391,7 @@ + @@ -39734,6 +44412,7 @@ + @@ -39747,12 +44426,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -39783,12 +44468,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -39806,6 +44498,7 @@ + @@ -39819,12 +44512,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -39842,6 +44541,7 @@ + @@ -39879,6 +44579,7 @@ + @@ -39937,6 +44638,7 @@ + @@ -40033,6 +44735,7 @@ + @@ -40148,6 +44851,7 @@ + @@ -40184,6 +44888,7 @@ + @@ -40202,6 +44907,7 @@ + @@ -40221,6 +44927,7 @@ + @@ -40238,6 +44945,7 @@ + @@ -40256,6 +44964,7 @@ + @@ -40271,12 +44980,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -40307,12 +45022,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + @@ -40330,6 +45051,7 @@ + @@ -40343,12 +45065,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220)

+ + + + @@ -40366,6 +45095,7 @@ + @@ -40384,6 +45114,7 @@ + @@ -40404,6 +45135,7 @@ + @@ -40438,6 +45170,11 @@ + + + + + @@ -40471,6 +45208,7 @@ + @@ -40507,6 +45245,7 @@ + @@ -40555,10 +45294,23 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + + @@ -40569,12 +45321,19 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + + @@ -40586,10 +45345,22 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + @@ -40599,13 +45370,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -40617,10 +45394,22 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + @@ -40630,13 +45419,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -40648,10 +45443,23 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + + + + + + + + @@ -40680,12 +45488,18 @@ + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220)

+ + - + + @@ -40697,13 +45511,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -40715,13 +45535,19 @@ - + + + +

NOTES: MetaNetX ID curated (PR #220) | ChEBI curated (PR #220) | metFormula curated (PR #222)

+ + - + + @@ -40757,6 +45583,7 @@ + @@ -40794,6 +45621,7 @@ + @@ -40839,6 +45667,8 @@ + + @@ -40862,6 +45692,8 @@ + + @@ -40885,6 +45717,8 @@ + + @@ -40908,6 +45742,8 @@ + + @@ -40920,12 +45756,18 @@ - + + + +

NOTES: metFormula curated (PR #222) | metCharge curated (PR #222)

+ + + @@ -40946,6 +45788,7 @@ + @@ -40966,6 +45809,7 @@ + @@ -40986,6 +45830,8 @@ + + @@ -41004,6 +45850,7 @@ + @@ -41020,6 +45867,11 @@ + + + + + @@ -41033,6 +45885,11 @@ + + + + + @@ -41539,6 +46396,7 @@ + @@ -41563,6 +46421,7 @@ + @@ -41588,6 +46447,7 @@ + @@ -41613,6 +46473,7 @@ + @@ -41638,6 +46499,7 @@ + @@ -41663,6 +46525,7 @@ + @@ -41677,10 +46540,10 @@ - + -

NOTES: added after new annotation (PR #142); based on kegg

+

NOTES: added after new annotation (PR #142); based on kegg | metFormula curated (PR #222)

 @@ -41688,6 +46551,7 @@ + @@ -41713,6 +46577,7 @@ + @@ -41727,10 +46592,10 @@ - + -

NOTES: added after new annotation (PR #142); based on kegg

+

NOTES: added after new annotation (PR #142); based on kegg | metCharge curated (PR #222) | metFormula curated (PR #222)

 @@ -41738,6 +46603,7 @@ + @@ -41763,7 +46629,9 @@ + + @@ -41786,6 +46654,7 @@ + @@ -41811,6 +46680,7 @@ + @@ -41837,6 +46707,7 @@ + @@ -41859,6 +46730,7 @@ + @@ -41910,6 +46782,8 @@ + + @@ -41932,6 +46806,7 @@ + @@ -41957,6 +46832,7 @@ + @@ -41982,6 +46858,7 @@ + @@ -42026,6 +46903,8 @@ + + @@ -42048,6 +46927,7 @@ + @@ -42073,6 +46953,7 @@ + @@ -42116,6 +46997,7 @@ + @@ -42151,12 +47033,17 @@ -

NOTES: added after new annotation (PR #142); based on kegg, G00011

+

NOTES: added after new annotation (PR #142); based on kegg, G00011 | MetaNetX ID curated (PR #220)

 + + + + + @@ -42177,6 +47064,7 @@ + @@ -42202,6 +47090,7 @@ + @@ -42227,6 +47116,7 @@ + @@ -42252,6 +47142,7 @@ + @@ -42277,6 +47168,7 @@ + @@ -42302,6 +47194,7 @@ + @@ -42327,6 +47220,7 @@ + @@ -42352,7 +47246,10 @@ + + + @@ -42375,7 +47272,10 @@ + + + @@ -42416,6 +47316,7 @@ + @@ -42459,6 +47360,7 @@ + @@ -42484,6 +47386,7 @@ + @@ -42595,6 +47498,7 @@ + @@ -42620,6 +47524,7 @@ + @@ -42646,6 +47551,8 @@ + + @@ -42693,6 +47600,7 @@ + @@ -42718,6 +47626,7 @@ + @@ -42743,6 +47652,7 @@ + @@ -42768,6 +47678,7 @@ + @@ -42793,6 +47704,7 @@ + @@ -42818,6 +47730,7 @@ + @@ -42843,6 +47756,7 @@ + @@ -42885,7 +47799,7 @@ -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXM2246 (PR #220)

 @@ -42895,7 +47809,7 @@ - + @@ -42907,10 +47821,10 @@ - + -

NOTES: added after new annotation (PR #142); Present in yeast model

+

NOTES: added after new annotation (PR #142); Present in yeast model | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -42918,6 +47832,7 @@ + @@ -42932,10 +47847,10 @@ - + -

NOTES: added after new annotation (PR #142); Present in yeast model

+

NOTES: added after new annotation (PR #142); Present in yeast model | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -42943,6 +47858,7 @@ + @@ -42960,7 +47876,7 @@ -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | MetaNetX ID curated (PR #220)

 @@ -42968,9 +47884,10 @@ + - + @@ -42993,6 +47910,7 @@ + @@ -43018,8 +47936,10 @@ + + @@ -43042,6 +47962,7 @@ + @@ -43067,6 +47988,7 @@ + @@ -43092,6 +48014,7 @@ + @@ -43163,6 +48086,7 @@ + @@ -43189,6 +48113,7 @@ + @@ -43211,6 +48136,7 @@ + @@ -43237,6 +48163,7 @@ + @@ -43259,6 +48186,7 @@ + @@ -43284,6 +48212,7 @@ + @@ -43309,6 +48238,7 @@ + @@ -43334,6 +48264,7 @@ + @@ -43357,6 +48288,7 @@ + @@ -43382,6 +48314,7 @@ + @@ -43406,6 +48339,7 @@ + @@ -43478,6 +48412,7 @@ + @@ -43505,6 +48440,7 @@ + @@ -43579,6 +48515,7 @@ + @@ -43626,6 +48563,7 @@ + @@ -43651,7 +48589,9 @@ + + @@ -43674,6 +48614,7 @@ + @@ -43699,7 +48640,9 @@ + + @@ -43772,6 +48715,7 @@ + @@ -43799,6 +48743,7 @@ + @@ -43846,6 +48791,7 @@ + @@ -43863,7 +48809,7 @@ -

NOTES: added after new annotation (PR #142); based on metnx

+

NOTES: added after new annotation (PR #142); based on metnx | MetaNetX ID curated (PR #220)

 @@ -43871,9 +48817,10 @@ + - + @@ -43896,6 +48843,7 @@ + @@ -43921,6 +48869,7 @@ + @@ -43938,7 +48887,7 @@ -

NOTES: added after new annotation (PR #142); based on metnx

+

NOTES: added after new annotation (PR #142); based on metnx | MetaNetX ID curated (PR #220)

 @@ -43946,9 +48895,10 @@ + - + @@ -43988,7 +48938,7 @@ -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | MetaNetX ID curated (PR #220)

 @@ -43998,7 +48948,7 @@ - + @@ -44023,6 +48973,7 @@ + @@ -44070,6 +49021,7 @@ + @@ -44084,10 +49036,10 @@ - + -

NOTES: added after new annotation (PR #142); General type

+

NOTES: added after new annotation (PR #142); General type | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -44102,10 +49054,10 @@ - + -

NOTES: added after new annotation (PR #142); General type

+

NOTES: added after new annotation (PR #142); General type | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -44156,6 +49108,7 @@ + @@ -44181,6 +49134,7 @@ + @@ -44206,6 +49160,7 @@ + @@ -44231,6 +49186,7 @@ + @@ -44281,6 +49237,7 @@ + @@ -44356,6 +49313,7 @@ + @@ -44381,6 +49339,7 @@ + @@ -44407,6 +49366,7 @@ + @@ -44454,6 +49414,7 @@ + @@ -44479,6 +49440,7 @@ + @@ -44529,6 +49491,7 @@ + @@ -44554,6 +49517,7 @@ + @@ -44629,6 +49593,7 @@ + @@ -44655,6 +49620,7 @@ + @@ -44677,6 +49643,7 @@ + @@ -44702,6 +49669,7 @@ + @@ -44727,6 +49695,7 @@ + @@ -44752,6 +49721,7 @@ + @@ -44841,12 +49811,17 @@ -

NOTES: added after new annotation (PR #142); based on kegg, G00008

+

NOTES: added after new annotation (PR #142); based on kegg, G00008 | MetaNetX ID curated (PR #220)

 + + + + + @@ -44859,7 +49834,7 @@ -

NOTES: added after new annotation (PR #142); based on Rhea

+

NOTES: added after new annotation (PR #142); based on Rhea | MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220)

 @@ -44868,6 +49843,8 @@ + + @@ -44913,6 +49890,7 @@ + @@ -44956,6 +49934,7 @@ + @@ -45053,6 +50032,7 @@ + @@ -45067,10 +50047,10 @@ - + -

NOTES: added after new annotation (PR #142); present in yeast model

+

NOTES: added after new annotation (PR #142); present in yeast model | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -45078,6 +50058,7 @@ + @@ -45103,6 +50084,7 @@ + @@ -45197,6 +50179,7 @@ + @@ -45219,6 +50202,7 @@ + @@ -45244,6 +50228,7 @@ + @@ -45269,6 +50254,7 @@ + @@ -45294,6 +50280,7 @@ + @@ -45308,10 +50295,10 @@ - + -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | ChEBI curated (PR #220) | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -45319,7 +50306,8 @@ - + + @@ -45361,7 +50349,7 @@ -

NOTES: added after new annotation (PR #142); based on metnx, MNXM37826

+

NOTES: added after new annotation (PR #142); based on metnx, MNXM37826 | MetaNetX ID curated (PR #220)

 @@ -45371,7 +50359,7 @@ - + @@ -45411,12 +50399,17 @@ -

NOTES: added after new annotation (PR #142); based on kegg, G10599

+

NOTES: added after new annotation (PR #142); based on kegg, G10599 | MetaNetX ID curated (PR #220) | MetaNetX ID curated (PR #220)

 + + + + + @@ -45437,6 +50430,7 @@ + @@ -45462,6 +50456,7 @@ + @@ -45487,6 +50482,7 @@ + @@ -45512,6 +50508,7 @@ + @@ -45633,6 +50630,7 @@ + @@ -45658,6 +50656,7 @@ + @@ -45685,6 +50684,7 @@ + @@ -45708,6 +50708,8 @@ + + @@ -45780,6 +50782,7 @@ + @@ -45794,15 +50797,20 @@ - + -

NOTES: added after new annotation (PR #142); based on kegg, G00012

+

NOTES: added after new annotation (PR #142); based on kegg, G00012 | MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

 + + + + + @@ -45823,6 +50831,7 @@ + @@ -45873,6 +50882,7 @@ + @@ -45898,7 +50908,9 @@ + + @@ -45921,6 +50933,7 @@ + @@ -45946,6 +50959,7 @@ + @@ -45971,6 +50985,7 @@ + @@ -46023,6 +51038,7 @@ + @@ -46034,10 +51050,10 @@ - + -

NOTES: added after new annotation (PR #142); based on metnx, MNXM4425

+

NOTES: added after new annotation (PR #142); based on metnx, MNXM4425 | MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

 @@ -46046,6 +51062,7 @@ + @@ -46057,10 +51074,10 @@ - + -

NOTES: added after new annotation (PR #142); based on metnx, MNXM2497

+

NOTES: added after new annotation (PR #142); based on metnx, MNXM2497 | MetaNetX ID curated (PR #220) | metFormula curated (PR #222)

 @@ -46069,6 +51086,7 @@ + @@ -46141,6 +51159,7 @@ + @@ -46191,6 +51210,7 @@ + @@ -46216,6 +51236,7 @@ + @@ -46241,6 +51262,7 @@ + @@ -46291,6 +51313,7 @@ + @@ -46305,10 +51328,10 @@ - + -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -46316,6 +51339,7 @@ + @@ -46341,6 +51365,7 @@ + @@ -46366,6 +51391,7 @@ + @@ -46441,6 +51467,7 @@ + @@ -46466,6 +51493,7 @@ + @@ -46491,6 +51519,7 @@ + @@ -46505,10 +51534,10 @@ - + -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -46516,6 +51545,7 @@ + @@ -46541,6 +51571,7 @@ + @@ -46566,6 +51597,7 @@ + @@ -46591,6 +51623,7 @@ + @@ -46605,10 +51638,10 @@ - + -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -46616,6 +51649,7 @@ + @@ -46641,6 +51675,7 @@ + @@ -46666,8 +51701,10 @@ + + @@ -46690,6 +51727,7 @@ + @@ -46704,10 +51742,10 @@ - + -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -46715,6 +51753,7 @@ + @@ -46740,6 +51779,7 @@ + @@ -46765,6 +51805,7 @@ + @@ -46904,10 +51945,10 @@ - + -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -46940,6 +51981,7 @@ + @@ -46954,10 +51996,10 @@ - + -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -46965,6 +52007,7 @@ + @@ -47004,10 +52047,10 @@ - + -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -47088,6 +52131,7 @@ + @@ -47114,6 +52158,7 @@ + @@ -47182,6 +52227,7 @@ + @@ -47207,6 +52253,7 @@ + @@ -47224,12 +52271,17 @@ -

NOTES: added after new annotation (PR #142); based on kegg, G10595

+

NOTES: added after new annotation (PR #142); based on kegg, G10595 | MetaNetX ID curated (PR #220)

 + + + + + @@ -47242,12 +52294,17 @@ -

NOTES: added after new annotation (PR #142); based on kegg, G10596

+

NOTES: added after new annotation (PR #142); based on kegg, G10596 | MetaNetX ID curated (PR #220)

 + + + + + @@ -47278,12 +52335,18 @@ -

NOTES: added after new annotation (PR #142); based on kegg, G00007

+

NOTES: added after new annotation (PR #142); based on kegg, G00007 | MetaNetX ID curated (PR #220)

 + + + + + + @@ -47304,6 +52367,7 @@ + @@ -47329,6 +52393,7 @@ + @@ -47354,6 +52419,7 @@ + @@ -47379,6 +52445,7 @@ + @@ -47395,12 +52462,17 @@ -

NOTES: added after new annotation (PR #142); based on kegg and Rhea, G10598

+

NOTES: added after new annotation (PR #142); based on kegg and Rhea, G10598 | MetaNetX ID curated (PR #220)

 + + + + + @@ -47413,12 +52485,17 @@ -

NOTES: added after new annotation (PR #142); based on kegg and Rhea, G00149

+

NOTES: added after new annotation (PR #142); based on kegg and Rhea, G00149 | MetaNetX ID curated (PR #220)

 + + + + + @@ -47431,12 +52508,17 @@ -

NOTES: added after new annotation (PR #142); based on kegg and Rhea, G00140

+

NOTES: added after new annotation (PR #142); based on kegg and Rhea, G00140 | MetaNetX ID curated (PR #220)

 + + + + + @@ -47482,6 +52564,7 @@ + @@ -47561,6 +52644,7 @@ + @@ -47586,6 +52670,7 @@ + @@ -47611,6 +52696,7 @@ + @@ -47625,10 +52711,10 @@ - + -

NOTES: added after new annotation (PR #142); based on chebi

+

NOTES: added after new annotation (PR #142); based on chebi | metFormula curated (PR #222) | metCharge curated (PR #222)

 @@ -47636,6 +52722,7 @@ + @@ -47661,6 +52748,7 @@ + @@ -47686,6 +52774,7 @@ + @@ -47703,7 +52792,7 @@ -

NOTES: added after new annotation (PR #142); Present in yeast model

+

NOTES: added after new annotation (PR #142); Present in yeast model | MetaNetX ID curated (PR #220)

 @@ -47711,9 +52800,10 @@ + - + @@ -47736,6 +52826,7 @@ + @@ -47761,6 +52852,7 @@ + @@ -47811,6 +52903,7 @@ + @@ -47836,6 +52929,7 @@ + @@ -47861,6 +52955,7 @@ + @@ -47954,6 +53049,7 @@ + @@ -47979,6 +53075,7 @@ + @@ -48004,6 +53101,7 @@ + @@ -48056,6 +53154,7 @@ + @@ -48103,6 +53202,7 @@ + @@ -48128,6 +53228,7 @@ + @@ -48175,6 +53276,7 @@ + @@ -48199,6 +53301,7 @@ + @@ -48223,6 +53326,7 @@ + @@ -48247,6 +53351,7 @@ + @@ -48272,6 +53377,7 @@ + @@ -48297,6 +53403,7 @@ + @@ -48322,6 +53429,7 @@ + @@ -48346,6 +53454,7 @@ + @@ -48370,6 +53479,7 @@ + @@ -48394,6 +53504,7 @@ + @@ -48515,6 +53626,7 @@ + @@ -48540,6 +53652,7 @@ + @@ -48565,6 +53678,7 @@ + @@ -48589,6 +53703,7 @@ + @@ -48613,6 +53728,7 @@ + @@ -48637,6 +53753,7 @@ + @@ -48661,6 +53778,7 @@ + @@ -48685,6 +53803,7 @@ + @@ -48709,6 +53828,7 @@ + @@ -48733,6 +53853,7 @@ + @@ -48757,6 +53878,7 @@ + @@ -48781,6 +53903,7 @@ + @@ -48805,6 +53928,7 @@ + @@ -48829,6 +53953,7 @@ + @@ -48853,6 +53978,7 @@ + @@ -48878,6 +54004,7 @@ + @@ -48903,6 +54030,7 @@ + @@ -48928,6 +54056,7 @@ + @@ -49001,6 +54130,7 @@ + @@ -49026,6 +54156,7 @@ + @@ -49051,6 +54182,7 @@ + @@ -49076,6 +54208,7 @@ + @@ -49125,6 +54258,7 @@ + @@ -49150,6 +54284,7 @@ + @@ -49224,6 +54359,7 @@ + @@ -49249,6 +54385,7 @@ + @@ -49274,6 +54411,7 @@ + @@ -49298,6 +54436,7 @@ + @@ -49372,6 +54511,7 @@ + @@ -49397,6 +54537,7 @@ + @@ -49422,6 +54563,7 @@ + @@ -49446,6 +54588,7 @@ + @@ -49470,6 +54613,7 @@ + @@ -49518,6 +54662,7 @@ + @@ -49567,6 +54712,7 @@ + @@ -49592,6 +54738,7 @@ + @@ -49617,6 +54764,7 @@ + @@ -49642,6 +54790,7 @@ + @@ -49667,6 +54816,7 @@ + @@ -49692,6 +54842,7 @@ + @@ -49717,6 +54868,7 @@ + @@ -49742,6 +54894,7 @@ + @@ -49767,6 +54920,7 @@ + @@ -49842,6 +54996,7 @@ + @@ -49867,6 +55022,7 @@ + @@ -49892,6 +55048,7 @@ + @@ -49917,6 +55074,7 @@ + @@ -49942,6 +55100,7 @@ + @@ -49967,6 +55126,7 @@ + @@ -49992,6 +55152,7 @@ + @@ -50017,6 +55178,7 @@ + @@ -50042,6 +55204,7 @@ + @@ -50067,6 +55230,7 @@ + @@ -50092,6 +55256,7 @@ + @@ -50117,6 +55282,7 @@ + @@ -50142,6 +55308,7 @@ + @@ -50167,6 +55334,7 @@ + @@ -50192,6 +55360,7 @@ + @@ -50217,6 +55386,7 @@ + @@ -50242,6 +55412,7 @@ + @@ -50267,6 +55438,7 @@ + @@ -50291,6 +55463,7 @@ + @@ -50315,6 +55488,7 @@ + @@ -50331,7 +55505,7 @@ -

NOTES: added after the Biolog update (PR #149)

+

NOTES: added after the Biolog update (PR #149) | MetaNetX ID curated (PR #220)

 @@ -50339,8 +55513,9 @@ + - + @@ -50363,6 +55538,7 @@ + @@ -50388,6 +55564,7 @@ + @@ -50405,7 +55582,7 @@ -

NOTES: added after the Biolog update (PR #149)

+

NOTES: added after the Biolog update (PR #149) | MetaNetX ID curated (PR #220)

 @@ -50413,8 +55590,9 @@ + - + @@ -50437,6 +55615,7 @@ + @@ -50462,6 +55641,7 @@ + @@ -50487,6 +55667,7 @@ + @@ -50512,6 +55693,7 @@ + @@ -50537,6 +55719,7 @@ + @@ -50587,6 +55770,7 @@ + @@ -50612,6 +55796,7 @@ + @@ -50637,6 +55822,7 @@ + @@ -50662,6 +55848,7 @@ + @@ -50737,6 +55924,7 @@ + @@ -50762,6 +55950,7 @@ + @@ -50787,6 +55976,7 @@ + @@ -50812,6 +56002,7 @@ + @@ -50837,6 +56028,7 @@ + @@ -50862,6 +56054,7 @@ + @@ -50886,6 +56079,7 @@ + @@ -50910,6 +56104,7 @@ + @@ -50935,6 +56130,7 @@ + @@ -50960,6 +56156,7 @@ + @@ -50985,6 +56182,7 @@ + @@ -51010,6 +56208,7 @@ + @@ -51035,6 +56234,7 @@ + @@ -51060,6 +56260,7 @@ + @@ -51085,6 +56286,7 @@ + @@ -51110,6 +56312,7 @@ + @@ -51135,6 +56338,7 @@ + @@ -51160,6 +56364,7 @@ + @@ -51185,6 +56390,7 @@ + @@ -51210,6 +56416,7 @@ + @@ -51235,6 +56442,7 @@ + @@ -51260,6 +56468,7 @@ + @@ -51285,6 +56494,7 @@ + @@ -51310,6 +56520,7 @@ + @@ -51335,6 +56546,7 @@ + @@ -51360,6 +56572,7 @@ + @@ -51385,6 +56598,7 @@ + @@ -51410,6 +56624,7 @@ + @@ -51435,6 +56650,7 @@ + @@ -51460,6 +56676,7 @@ + @@ -51485,6 +56702,7 @@ + @@ -51509,6 +56727,7 @@ + @@ -51533,6 +56752,7 @@ + @@ -51557,6 +56777,7 @@ + @@ -51581,6 +56802,7 @@ + @@ -51606,6 +56828,7 @@ + @@ -51631,6 +56854,7 @@ + @@ -51656,6 +56880,7 @@ + @@ -51681,6 +56906,7 @@ + @@ -51706,6 +56932,7 @@ + @@ -51731,6 +56958,7 @@ + @@ -51756,6 +56984,7 @@ + @@ -51781,8 +57010,9 @@ + - + @@ -51806,6 +57036,7 @@ + @@ -51831,6 +57062,7 @@ + @@ -51856,6 +57088,7 @@ + @@ -51881,6 +57114,7 @@ + @@ -51906,6 +57140,7 @@ + @@ -51931,6 +57166,7 @@ + @@ -51981,6 +57217,7 @@ + @@ -52006,6 +57243,7 @@ + @@ -52031,6 +57269,7 @@ + @@ -52056,6 +57295,7 @@ + @@ -52081,6 +57321,7 @@ + @@ -52106,6 +57347,7 @@ + @@ -52131,6 +57373,7 @@ + @@ -52156,6 +57399,7 @@ + @@ -52181,8 +57425,10 @@ + + @@ -52205,8 +57451,10 @@ + + @@ -52229,8 +57477,10 @@ + + @@ -52253,8 +57503,10 @@ + + @@ -52277,8 +57529,10 @@ + + @@ -52301,8 +57555,10 @@ + + @@ -52325,8 +57581,10 @@ + + @@ -52349,8 +57607,10 @@ + + @@ -52373,8 +57633,10 @@ + + @@ -52422,6 +57684,46 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -52435,6 +57737,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -52442,10 +57745,11 @@ + - + @@ -52489,6 +57793,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -52496,10 +57801,11 @@ + - + @@ -52542,6 +57848,7 @@ + @@ -52572,6 +57879,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -52579,9 +57887,10 @@ + - + @@ -52617,6 +57926,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -52631,7 +57941,7 @@ - + @@ -52709,6 +58019,7 @@ + @@ -52748,7 +58059,9 @@ + + @@ -52823,6 +58136,7 @@

Confidence Level: 3

+

NOTES: KEGG ID curated (PR #220)

 @@ -52835,8 +58149,10 @@ + + @@ -52919,6 +58235,7 @@ + @@ -53007,6 +58324,7 @@ + @@ -53049,6 +58367,7 @@ + @@ -53086,6 +58405,7 @@ + @@ -53131,6 +58451,7 @@ + @@ -53185,6 +58506,7 @@ + @@ -53238,6 +58560,7 @@ + @@ -53278,6 +58601,7 @@ + @@ -53324,6 +58648,7 @@ + @@ -53400,6 +58725,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -53414,7 +58740,7 @@ - + @@ -53452,6 +58778,7 @@ + @@ -53490,6 +58817,7 @@ + @@ -53526,6 +58854,7 @@ + @@ -53567,6 +58896,7 @@ + @@ -53603,6 +58933,7 @@ + @@ -53643,6 +58974,7 @@ + @@ -53678,6 +59010,7 @@ + @@ -53713,6 +59046,7 @@ + @@ -53749,6 +59083,7 @@ + @@ -53789,6 +59124,7 @@ + @@ -53825,6 +59161,7 @@ + @@ -53869,6 +59206,7 @@ + @@ -53901,6 +59239,7 @@

Confidence Level: 3

+

NOTES: model.S(602,36) curated (PR #222)

 @@ -53929,7 +59268,7 @@ - + @@ -53956,6 +59295,7 @@ + @@ -54001,6 +59341,7 @@ + @@ -54074,6 +59415,7 @@

Confidence Level: 2

+

NOTES: model.S(601,40) curated (PR #222)

 @@ -54081,6 +59423,7 @@ + @@ -54100,6 +59443,7 @@ + @@ -54117,6 +59461,7 @@ + @@ -54148,6 +59493,7 @@

Confidence Level: 3

+

NOTES: KEGG ID curated (PR #220) | model.S(601,42) curated (PR #222)

 @@ -54160,7 +59506,9 @@ + + @@ -54178,7 +59526,6 @@ - @@ -54239,6 +59586,7 @@ + @@ -54279,6 +59627,7 @@ + @@ -54321,6 +59670,7 @@ + @@ -54363,6 +59713,7 @@ + @@ -54405,6 +59756,7 @@ + @@ -54454,6 +59806,7 @@ + @@ -54494,6 +59847,7 @@ + @@ -54530,6 +59884,7 @@ + @@ -54571,6 +59926,7 @@ + @@ -54612,6 +59968,7 @@ + @@ -54653,6 +60010,7 @@ + @@ -54679,6 +60037,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -54691,8 +60050,9 @@ + - + @@ -54719,6 +60079,7 @@

Confidence Level: 3

+

NOTES: model.S(601,56) curated (PR #222)

 @@ -54752,7 +60113,7 @@ - + @@ -54767,6 +60128,7 @@

Confidence Level: 3

+

NOTES: model.S(601,57) curated (PR #222) | model.S(610,57) curated (PR #222)

 @@ -54793,12 +60155,11 @@ - + - @@ -54820,6 +60181,7 @@ + @@ -54862,6 +60224,7 @@ + @@ -54906,6 +60269,7 @@ + @@ -54948,6 +60312,7 @@ + @@ -54987,6 +60352,7 @@ + @@ -55021,6 +60387,7 @@

Confidence Level: 3

+

NOTES: model.S(601,63) curated (PR #222)

 @@ -55033,6 +60400,7 @@ + @@ -55048,7 +60416,7 @@ - + @@ -55073,6 +60441,7 @@ + @@ -55104,6 +60473,7 @@

Confidence Level: 3

+

NOTES: model.S(601,65) curated (PR #222)

 @@ -55135,7 +60505,7 @@ - + @@ -55147,6 +60517,7 @@

Confidence Level: 3

+

NOTES: model.S(601,66) curated (PR #222)

 @@ -55174,7 +60545,6 @@ - @@ -55196,6 +60566,7 @@ + @@ -55238,6 +60609,7 @@ + @@ -55267,6 +60639,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -55279,8 +60652,9 @@ + - + @@ -55318,6 +60692,7 @@ + @@ -55433,6 +60808,7 @@ + @@ -55477,6 +60853,7 @@ + @@ -55509,6 +60886,7 @@

Confidence Level: 3

+

NOTES: model.S(601,75) curated (PR #222)

 @@ -55542,7 +60920,7 @@ - + @@ -55557,6 +60935,7 @@

Confidence Level: 3

+

NOTES: alternative MetaNetX ID MNXR112453 (PR #220) | alternative KEGG ID R08964 (PR #220) | model.S(601,76) curated (PR #222) | model.S(610,76) curated (PR #222)

 @@ -55583,12 +60962,11 @@ - + - @@ -55598,6 +60976,7 @@

Confidence Level: 3

+

NOTES: model.S(601,77) curated (PR #222)

 @@ -55623,6 +61002,7 @@ + @@ -55630,7 +61010,6 @@ - @@ -55649,6 +61028,7 @@ + @@ -55781,6 +61161,7 @@ + @@ -55816,6 +61197,7 @@ + @@ -55851,6 +61233,7 @@ + @@ -55886,6 +61269,7 @@ + @@ -55922,7 +61306,9 @@ + + @@ -55956,7 +61342,9 @@ + + @@ -55990,6 +61378,7 @@ + @@ -56026,6 +61415,7 @@ + @@ -56103,6 +61493,7 @@ + @@ -56143,6 +61534,7 @@ + @@ -56185,6 +61577,7 @@ + @@ -56227,6 +61620,7 @@ + @@ -56268,6 +61662,7 @@ + @@ -56349,6 +61744,7 @@ + @@ -56391,6 +61787,7 @@ + @@ -56437,6 +61834,7 @@ + @@ -56470,6 +61868,7 @@ + @@ -56506,7 +61905,9 @@ + + @@ -56577,6 +61978,7 @@ + @@ -56612,6 +62014,7 @@ + @@ -56647,6 +62050,7 @@ + @@ -56682,6 +62086,7 @@ + @@ -56717,6 +62122,7 @@ + @@ -57189,7 +62595,9 @@ + + @@ -57230,6 +62638,7 @@ + @@ -57269,7 +62678,9 @@ + + @@ -57305,6 +62716,7 @@ + @@ -57342,7 +62754,9 @@ + + @@ -57383,6 +62797,7 @@ + @@ -57424,6 +62839,7 @@ + @@ -57460,6 +62876,7 @@ + @@ -57496,6 +62913,7 @@ + @@ -57531,6 +62949,7 @@ + @@ -57569,6 +62988,7 @@ + @@ -57604,6 +63024,7 @@ + @@ -57639,6 +63060,7 @@ + @@ -57674,6 +63096,7 @@ + @@ -57709,6 +63132,7 @@ + @@ -57753,6 +63177,7 @@ + @@ -57783,6 +63208,7 @@

Confidence Level: 3

+

NOTES: model.S(601,134) curated (PR #222)

 @@ -57795,6 +63221,7 @@ + @@ -57809,11 +63236,11 @@ - + @@ -57830,6 +63257,7 @@ + @@ -57871,6 +63299,7 @@ + @@ -57914,6 +63343,7 @@ + @@ -58000,6 +63430,7 @@ + @@ -58043,6 +63474,7 @@ + @@ -58086,6 +63518,7 @@ + @@ -58129,6 +63562,7 @@ + @@ -58171,6 +63605,7 @@ + @@ -58217,6 +63652,7 @@ + @@ -58262,6 +63698,7 @@ + @@ -58309,6 +63746,7 @@ + @@ -58354,6 +63792,7 @@ + @@ -58400,6 +63839,7 @@ + @@ -58448,6 +63888,7 @@ + @@ -58494,6 +63935,7 @@ + @@ -58538,7 +63980,9 @@ + + @@ -58584,6 +64028,7 @@ + @@ -58627,6 +64072,7 @@ + @@ -58670,6 +64116,7 @@ + @@ -58711,6 +64158,7 @@ + @@ -58749,6 +64197,7 @@ + @@ -58791,6 +64240,7 @@ + @@ -58824,6 +64274,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -58836,11 +64287,12 @@ + - + @@ -58872,6 +64324,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -58884,9 +64337,10 @@ + - + @@ -58917,6 +64371,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -58930,9 +64385,10 @@ + - + @@ -58975,6 +64431,7 @@ + @@ -59022,6 +64479,7 @@ + @@ -59067,6 +64525,7 @@ + @@ -59111,6 +64570,7 @@ + @@ -59157,6 +64617,7 @@ + @@ -59205,6 +64666,7 @@ + @@ -59238,6 +64700,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -59245,11 +64708,12 @@ + - + @@ -59277,6 +64741,7 @@

Confidence Level: 3

+

NOTES: KEGG ID curated (PR #220)

 @@ -59289,7 +64754,9 @@ + + @@ -59329,6 +64796,7 @@ + @@ -59365,8 +64833,10 @@ + + @@ -59395,6 +64865,7 @@

Confidence Level: 3

+

NOTES: model.S(604,171) curated (PR #222)

 @@ -59426,11 +64897,11 @@ + - @@ -59456,7 +64927,9 @@ + + @@ -59498,7 +64971,9 @@ + + @@ -59525,6 +65000,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -59537,10 +65013,11 @@ + - + @@ -59579,6 +65056,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220) | alternative KEGG ID R06084 (PR #220)

 @@ -59586,10 +65064,11 @@ + - - + + @@ -59629,7 +65108,9 @@ + + @@ -59672,6 +65153,8 @@ + + @@ -59705,6 +65188,7 @@ + @@ -59743,6 +65227,7 @@ + @@ -59784,6 +65269,7 @@ + @@ -59825,6 +65311,7 @@ + @@ -59861,6 +65348,7 @@ + @@ -59899,7 +65387,9 @@ + + @@ -59927,6 +65417,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -59934,9 +65425,10 @@ + - + @@ -59962,6 +65454,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -59974,9 +65467,10 @@ + - + @@ -60013,6 +65507,7 @@ + @@ -60051,6 +65546,7 @@ + @@ -60094,6 +65590,7 @@ + @@ -60143,6 +65640,7 @@ + @@ -60186,6 +65684,7 @@ + @@ -60224,6 +65723,7 @@ + @@ -60267,6 +65767,7 @@ + @@ -60308,6 +65809,7 @@ + @@ -60349,6 +65851,7 @@ + @@ -60390,6 +65893,7 @@ + @@ -60431,6 +65935,7 @@ + @@ -60474,6 +65979,7 @@ + @@ -60517,6 +66023,7 @@ + @@ -60555,6 +66062,7 @@ + @@ -60593,6 +66101,7 @@ + @@ -60630,6 +66139,7 @@ + @@ -60667,6 +66177,7 @@ + @@ -60709,6 +66220,7 @@ + @@ -60808,8 +66320,10 @@ + + @@ -60850,6 +66364,7 @@

Confidence Level: 3

+

NOTES: model.S(601,205) curated (PR #222)

 @@ -60882,6 +66397,7 @@ + @@ -60937,6 +66453,7 @@ + @@ -60978,6 +66495,7 @@ + @@ -61015,7 +66533,9 @@ + + @@ -61046,6 +66566,7 @@

Confidence Level: 3

+

NOTES: model.S(601,210) curated (PR #222)

 @@ -61075,7 +66596,6 @@ - @@ -61087,6 +66607,7 @@

Confidence Level: 2

+

NOTES: model.S(601,211) curated (PR #222)

 @@ -61113,7 +66634,6 @@ - @@ -61168,6 +66688,7 @@ + @@ -61242,6 +66763,7 @@ + @@ -61273,6 +66795,7 @@

Confidence Level: 3

+

NOTES: model.S(601,216) curated (PR #222)

 @@ -61297,7 +66820,6 @@ - @@ -61315,6 +66837,7 @@

Confidence Level: 2

+

NOTES: model.S(601,217) curated (PR #222)

 @@ -61337,7 +66860,7 @@ - + @@ -61361,6 +66884,7 @@ + @@ -61399,6 +66923,7 @@ + @@ -61433,6 +66958,7 @@ + @@ -61463,6 +66989,7 @@

Confidence Level: 3

+

NOTES: model.S(601,221) curated (PR #222)

 @@ -61494,7 +67021,6 @@ - @@ -61515,6 +67041,7 @@ + @@ -61566,7 +67093,9 @@ + + @@ -61604,7 +67133,9 @@ + + @@ -61639,7 +67170,9 @@ + + @@ -61667,6 +67200,7 @@

Confidence Level: 3

+

NOTES: KEGG ID curated (PR #220)

 @@ -61679,7 +67213,9 @@ + + @@ -61718,7 +67254,9 @@ + + @@ -61935,6 +67473,7 @@ + @@ -61973,6 +67512,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXR110315 (PR #220)

 @@ -61987,9 +67527,10 @@ + - + @@ -62040,6 +67581,7 @@ + @@ -62078,6 +67620,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXR110323 (PR #220)

 @@ -62092,9 +67635,10 @@ + - + @@ -62307,6 +67851,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR96718 (PR #220)

 @@ -62404,6 +67949,7 @@ + @@ -62441,6 +67987,7 @@ + @@ -62483,6 +68030,7 @@ + @@ -62522,6 +68070,7 @@ + @@ -62562,6 +68111,7 @@ + @@ -63415,7 +68965,9 @@ + + @@ -63460,7 +69012,9 @@ + + @@ -63502,6 +69056,7 @@ + @@ -63542,6 +69097,7 @@ + @@ -63577,6 +69133,7 @@ + @@ -63615,6 +69172,7 @@ + @@ -63659,7 +69217,9 @@ + + @@ -63705,7 +69265,9 @@ + + @@ -63749,6 +69311,7 @@ + @@ -63790,7 +69353,9 @@ + + @@ -63831,6 +69396,7 @@ + @@ -63861,6 +69427,7 @@

Confidence Level: 3

+

NOTES: model.S(601,277) curated (PR #222)

 @@ -63874,6 +69441,7 @@ + @@ -63894,7 +69462,6 @@ - @@ -63917,6 +69484,7 @@ + @@ -63955,7 +69523,9 @@ + + @@ -63991,6 +69561,7 @@ + @@ -64033,6 +69604,7 @@ + @@ -64077,7 +69649,9 @@ + + @@ -64106,6 +69680,7 @@

Confidence Level: 3

+

NOTES: model.S(601,283) curated (PR #222)

 @@ -64137,6 +69712,7 @@ + @@ -64159,6 +69735,7 @@ + @@ -64196,6 +69773,7 @@ + @@ -64233,6 +69811,7 @@ + @@ -64268,6 +69847,7 @@ + @@ -64308,7 +69888,9 @@ + + @@ -64344,7 +69926,9 @@ + + @@ -64380,7 +69964,9 @@ + + @@ -64416,7 +70002,9 @@ + + @@ -64452,6 +70040,7 @@ + @@ -64525,6 +70114,7 @@ + @@ -64562,6 +70152,7 @@ + @@ -64599,6 +70190,7 @@ + @@ -64631,6 +70223,7 @@

Confidence Level: 3

+

NOTES: model.S(611,297) curated (PR #222)

 @@ -64662,6 +70255,7 @@ + @@ -64671,6 +70265,7 @@

Confidence Level: 3

+

NOTES: model.S(611,298) curated (PR #222)

 @@ -64701,6 +70296,7 @@ + @@ -64710,6 +70306,7 @@

Confidence Level: 3

+

NOTES: model.S(611,299) curated (PR #222)

 @@ -64737,6 +70334,7 @@ + @@ -64750,6 +70348,7 @@

Confidence Level: 3

+

NOTES: model.S(611,300) curated (PR #222)

 @@ -64777,6 +70376,7 @@ + @@ -64797,6 +70397,7 @@ + @@ -64834,6 +70435,7 @@ + @@ -64864,6 +70466,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -64876,9 +70479,10 @@ + - + @@ -64945,6 +70549,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -64952,9 +70557,10 @@ + - + @@ -64993,6 +70599,7 @@ + @@ -65022,6 +70629,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -65033,7 +70641,7 @@ - + @@ -65060,6 +70668,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -65067,11 +70676,12 @@ + - + @@ -65110,6 +70720,7 @@ + @@ -65150,6 +70761,7 @@ + @@ -65185,6 +70797,7 @@ + @@ -65226,6 +70839,7 @@ + @@ -65268,6 +70882,7 @@ + @@ -65296,6 +70911,7 @@

Confidence Level: 3

+

NOTES: model.S(601,314) curated (PR #222)

 @@ -65325,7 +70941,7 @@ - + @@ -65337,6 +70953,7 @@

Confidence Level: 3

+

NOTES: model.S(601,315) curated (PR #222)

 @@ -65362,7 +70979,7 @@ - + @@ -65391,6 +71008,7 @@ + @@ -65421,6 +71039,7 @@

Confidence Level: 2

+

NOTES: model.S(601,317) curated (PR #222)

 @@ -65428,6 +71047,7 @@ + @@ -65444,11 +71064,11 @@ + - @@ -65458,6 +71078,7 @@

Confidence Level: 2

+

NOTES: model.S(601,318) curated (PR #222)

 @@ -65465,6 +71086,7 @@ + @@ -65485,6 +71107,7 @@ + @@ -65494,6 +71117,7 @@

Confidence Level: 2

+

NOTES: model.S(602,319) curated (PR #222)

 @@ -65501,6 +71125,7 @@ + @@ -65518,7 +71143,6 @@ - @@ -65544,6 +71168,7 @@ + @@ -65580,6 +71205,7 @@ + @@ -65625,6 +71251,7 @@ + @@ -65663,6 +71290,7 @@ + @@ -65709,6 +71337,7 @@ + @@ -65796,6 +71425,7 @@ + @@ -65843,6 +71473,7 @@ + @@ -65919,6 +71550,7 @@ + @@ -65956,6 +71588,7 @@ + @@ -65994,6 +71627,7 @@ + @@ -66031,6 +71665,7 @@ + @@ -66068,6 +71703,7 @@ + @@ -66097,6 +71733,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -66104,9 +71741,10 @@ + - + @@ -66142,6 +71780,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -66156,7 +71795,7 @@ - + @@ -66324,6 +71963,7 @@ + @@ -66354,6 +71994,7 @@

Confidence Level: 3

+

NOTES: model.S(601,338) curated (PR #222)

 @@ -66366,6 +72007,7 @@ + @@ -66381,7 +72023,7 @@ - + @@ -66396,6 +72038,7 @@

Confidence Level: 3

+

NOTES: model.S(601,339) curated (PR #222)

 @@ -66408,6 +72051,7 @@ + @@ -66423,7 +72067,7 @@ - + @@ -66445,6 +72089,7 @@ + @@ -66484,6 +72129,7 @@ + @@ -66527,6 +72173,7 @@ + @@ -66574,6 +72221,7 @@ + @@ -66614,6 +72262,7 @@ + @@ -66646,6 +72295,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR144209 (PR #220)

 @@ -66653,6 +72303,7 @@ + @@ -66694,6 +72345,7 @@ + @@ -66733,6 +72385,7 @@ + @@ -66774,6 +72427,7 @@ + @@ -66814,6 +72468,7 @@ + @@ -66843,6 +72498,7 @@

Confidence Level: 3

+

NOTES: model.S(606,350) curated (PR #222)

 @@ -66857,6 +72513,7 @@ + @@ -66876,6 +72533,7 @@ + @@ -66886,6 +72544,7 @@

Confidence Level: 3

+

NOTES: model.S(601,351) curated (PR #222)

 @@ -66898,6 +72557,7 @@ + @@ -66917,6 +72577,7 @@ + @@ -66934,6 +72595,7 @@ + @@ -66970,6 +72632,7 @@ + @@ -67007,6 +72670,7 @@ + @@ -67044,6 +72708,7 @@ + @@ -67088,6 +72753,7 @@ + @@ -67120,6 +72786,7 @@ + @@ -67162,6 +72829,7 @@ + @@ -67202,6 +72870,7 @@ + @@ -67241,6 +72910,7 @@ + @@ -67277,6 +72947,7 @@ + @@ -67307,6 +72978,7 @@

Confidence Level: 3

+

NOTES: alternative MetaNetX ID MNXR130328 (PR #220)

 @@ -67319,6 +72991,7 @@ + @@ -67353,6 +73026,7 @@ + @@ -67394,6 +73068,7 @@ + @@ -67435,7 +73110,9 @@ + + @@ -67473,7 +73150,9 @@ + + @@ -67519,6 +73198,7 @@ + @@ -67557,6 +73237,7 @@ + @@ -67600,6 +73281,8 @@ + + @@ -67642,7 +73325,9 @@ + + @@ -67673,6 +73358,7 @@

Confidence Level: 3

+

NOTES: alternative MetaNetX ID MNXR124393 (PR #220)

 @@ -67685,6 +73371,7 @@ + @@ -67729,6 +73416,7 @@ + @@ -67767,6 +73455,7 @@ + @@ -67810,6 +73499,7 @@ + @@ -67848,6 +73538,7 @@ + @@ -67907,6 +73598,7 @@ + @@ -67947,6 +73639,7 @@ + @@ -67996,6 +73689,7 @@ + @@ -68031,6 +73725,7 @@ + @@ -68075,7 +73770,9 @@ + + @@ -68121,7 +73818,9 @@ + + @@ -68157,6 +73856,7 @@ + @@ -68194,6 +73894,7 @@ + @@ -68226,6 +73927,7 @@

Confidence Level: 2

+

NOTES: model.S(606,384) curated (PR #222)

 @@ -68233,6 +73935,7 @@ + @@ -68249,6 +73952,7 @@ + @@ -68274,6 +73978,7 @@ + @@ -68314,6 +74019,7 @@ + @@ -68356,6 +74062,7 @@ + @@ -68393,6 +74100,7 @@ + @@ -68435,6 +74143,7 @@ + @@ -68467,6 +74176,7 @@ + @@ -68504,6 +74214,7 @@

Confidence Level: 3

+

NOTES: alternative MetaNetX ID MNXR124474 (PR #220)

 @@ -68516,6 +74227,7 @@ + @@ -68546,6 +74258,7 @@

Confidence Level: 3

+

NOTES: alternative MetaNetX ID MNXR124474 (PR #220)

 @@ -68559,6 +74272,7 @@ + @@ -68596,6 +74310,7 @@ + @@ -68639,6 +74354,7 @@ + @@ -68685,6 +74401,7 @@

Confidence Level: 2

+

NOTES: model.S(606,395) curated (PR #222)

 @@ -68692,6 +74409,7 @@ + @@ -68708,7 +74426,6 @@ - @@ -68729,6 +74446,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220) | model.S(606,396) curated (PR #222)

 @@ -68736,9 +74454,12 @@ + + + @@ -68750,6 +74471,7 @@ + @@ -68778,6 +74500,7 @@ + @@ -68822,6 +74545,7 @@ + @@ -68857,6 +74581,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | model.S(610,399) curated (PR #222)

 @@ -68871,7 +74596,7 @@ - + @@ -68883,7 +74608,6 @@ - @@ -68923,6 +74647,7 @@ + @@ -68962,6 +74687,7 @@ + @@ -69003,6 +74729,7 @@ + @@ -69037,6 +74764,7 @@

Confidence Level: 3

+

NOTES: alternative MetaNetX ID MNXR95258 (PR #220) | KEGG ID curated (PR #220)

 @@ -69050,7 +74778,7 @@ - + @@ -69285,6 +75013,7 @@ + @@ -69322,6 +75051,7 @@ + @@ -69365,7 +75095,9 @@ + + @@ -69401,6 +75133,7 @@ + @@ -69437,6 +75170,7 @@ + @@ -69473,6 +75207,7 @@ + @@ -69513,6 +75248,7 @@ + @@ -69561,6 +75297,7 @@ + @@ -69645,6 +75382,7 @@ + @@ -69679,6 +75417,7 @@

Confidence Level: 3

+

Alternative Name: ATP D-glucose 6-phosphotransferase

 @@ -69691,6 +75430,7 @@ + @@ -69720,6 +75460,7 @@ + @@ -69734,6 +75475,7 @@ + @@ -69775,6 +75517,7 @@ + @@ -69815,6 +75558,7 @@ + @@ -69851,6 +75595,7 @@ + @@ -69892,6 +75637,7 @@ + @@ -69935,6 +75681,7 @@ + @@ -69966,6 +75713,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -69978,9 +75726,10 @@ + - + @@ -70020,6 +75769,7 @@ + @@ -70051,6 +75801,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -70060,7 +75811,7 @@ - + @@ -70104,6 +75855,7 @@ + @@ -70137,6 +75889,7 @@

Confidence Level: 3

+

NOTES: model.S(606,430) curated (PR #222)

 @@ -70150,6 +75903,7 @@ + @@ -70168,7 +75922,6 @@ - @@ -70192,6 +75945,7 @@ + @@ -70234,6 +75988,7 @@ + @@ -70276,6 +76031,7 @@ + @@ -70318,6 +76074,7 @@ + @@ -70347,6 +76104,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | model.S(601,435) curated (PR #222)

 @@ -70359,7 +76117,9 @@ + + @@ -70371,6 +76131,7 @@ + @@ -70395,6 +76156,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | model.S(606,436) curated (PR #222)

 @@ -70407,7 +76169,9 @@ + + @@ -70419,6 +76183,7 @@ + @@ -70437,6 +76202,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | model.S(608,437) curated (PR #222)

 @@ -70449,7 +76215,9 @@ + + @@ -70461,6 +76229,7 @@ + @@ -70492,6 +76261,7 @@ + @@ -70529,6 +76299,7 @@ + @@ -70566,6 +76337,7 @@ + @@ -70602,6 +76374,7 @@ + @@ -70640,7 +76413,9 @@ + + @@ -70668,6 +76443,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR100659 (PR #220)

 @@ -70675,6 +76451,7 @@ + @@ -70709,6 +76486,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR100660 (PR #220)

 @@ -70716,6 +76494,7 @@ + @@ -70754,6 +76533,7 @@ + @@ -70792,6 +76572,7 @@ + @@ -70834,6 +76615,7 @@ + @@ -70870,6 +76652,7 @@ + @@ -70909,6 +76692,7 @@ + @@ -70949,6 +76733,7 @@ + @@ -70996,6 +76781,7 @@ + @@ -71039,6 +76825,7 @@ + @@ -71087,7 +76874,9 @@ + + @@ -71127,7 +76916,9 @@ + + @@ -71162,6 +76953,7 @@ + @@ -71194,6 +76986,7 @@

Confidence Level: 3

+

NOTES: model.S(607,456) curated (PR #222)

 @@ -71221,11 +77014,11 @@ - + @@ -71236,6 +77029,7 @@

Confidence Level: 3

+

NOTES: model.S(607,457) curated (PR #222)

 @@ -71249,6 +77043,7 @@ + @@ -71263,10 +77058,10 @@ - + @@ -71277,6 +77072,7 @@

Confidence Level: 3

+

NOTES: model.S(607,458) curated (PR #222)

 @@ -71305,10 +77101,10 @@ - + @@ -71319,6 +77115,7 @@

Confidence Level: 3

+

NOTES: model.S(607,459) curated (PR #222)

 @@ -71347,11 +77144,11 @@ - + @@ -71361,6 +77158,7 @@

Confidence Level: 3

+

NOTES: model.S(607,460) curated (PR #222)

 @@ -71389,11 +77187,11 @@ - + @@ -72203,6 +78001,7 @@

Confidence Level: 3

+

NOTES: model.S(606,481) curated (PR #222)

 @@ -72234,6 +78033,7 @@ + @@ -72243,6 +78043,7 @@

Confidence Level: 3

+

NOTES: model.S(606,482) curated (PR #222)

 @@ -72274,6 +78075,7 @@ + @@ -72283,6 +78085,7 @@

Confidence Level: 3

+

NOTES: model.S(606,483) curated (PR #222)

 @@ -72314,6 +78117,7 @@ + @@ -72323,6 +78127,7 @@

Confidence Level: 3

+

NOTES: model.S(606,484) curated (PR #222)

 @@ -72354,6 +78159,7 @@ + @@ -72363,6 +78169,7 @@

Confidence Level: 3

+

NOTES: model.S(606,485) curated (PR #222)

 @@ -72394,6 +78201,7 @@ + @@ -72403,6 +78211,7 @@

Confidence Level: 3

+

NOTES: model.S(606,486) curated (PR #222)

 @@ -72434,6 +78243,7 @@ + @@ -72443,6 +78253,7 @@

Confidence Level: 3

+

NOTES: model.S(606,487) curated (PR #222)

 @@ -72474,6 +78285,7 @@ + @@ -72483,6 +78295,7 @@

Confidence Level: 3

+

NOTES: model.S(606,488) curated (PR #222)

 @@ -72514,6 +78327,7 @@ + @@ -72523,6 +78337,7 @@

Confidence Level: 3

+

NOTES: model.S(606,489) curated (PR #222)

 @@ -72554,6 +78369,7 @@ + @@ -72563,6 +78379,7 @@

Confidence Level: 3

+

NOTES: model.S(606,490) curated (PR #222)

 @@ -72594,6 +78411,7 @@ + @@ -73403,6 +79221,7 @@

Confidence Level: 3

+

NOTES: model.S(602,511) curated (PR #222)

 @@ -73434,6 +79253,7 @@ + @@ -73443,6 +79263,7 @@

Confidence Level: 3

+

NOTES: model.S(602,512) curated (PR #222)

 @@ -73474,6 +79295,7 @@ + @@ -73483,6 +79305,7 @@

Confidence Level: 3

+

NOTES: model.S(602,513) curated (PR #222)

 @@ -73514,6 +79337,7 @@ + @@ -73523,6 +79347,7 @@

Confidence Level: 3

+

NOTES: model.S(602,514) curated (PR #222)

 @@ -73554,6 +79379,7 @@ + @@ -73563,6 +79389,7 @@

Confidence Level: 3

+

NOTES: model.S(602,515) curated (PR #222)

 @@ -73594,6 +79421,7 @@ + @@ -73603,6 +79431,7 @@

Confidence Level: 3

+

NOTES: model.S(602,516) curated (PR #222)

 @@ -73634,6 +79463,7 @@ + @@ -73643,6 +79473,7 @@

Confidence Level: 3

+

NOTES: model.S(602,517) curated (PR #222)

 @@ -73674,6 +79505,7 @@ + @@ -73683,6 +79515,7 @@

Confidence Level: 3

+

NOTES: model.S(602,518) curated (PR #222)

 @@ -73714,6 +79547,7 @@ + @@ -73723,6 +79557,7 @@

Confidence Level: 3

+

NOTES: model.S(602,519) curated (PR #222)

 @@ -73754,6 +79589,7 @@ + @@ -73763,6 +79599,7 @@

Confidence Level: 3

+

NOTES: model.S(602,520) curated (PR #222)

 @@ -73794,6 +79631,7 @@ + @@ -73815,6 +79653,7 @@ + @@ -73856,6 +79695,7 @@ + @@ -73897,6 +79737,7 @@ + @@ -73942,7 +79783,9 @@ + + @@ -73983,6 +79826,7 @@ + @@ -74020,6 +79864,7 @@ + @@ -74061,6 +79906,7 @@ + @@ -74102,6 +79948,7 @@ + @@ -74143,6 +79990,7 @@ + @@ -74186,6 +80034,7 @@ + @@ -74224,6 +80073,7 @@ + @@ -74263,6 +80113,7 @@ + @@ -74309,6 +80160,7 @@ + @@ -74350,6 +80202,7 @@ + @@ -74392,6 +80245,7 @@ + @@ -74431,6 +80285,7 @@ + @@ -74469,6 +80324,7 @@ + @@ -74507,6 +80363,7 @@ + @@ -74548,6 +80405,7 @@ + @@ -74588,7 +80446,9 @@ + + @@ -74629,6 +80489,7 @@ + @@ -74678,7 +80539,9 @@ + + @@ -74718,7 +80581,9 @@ + + @@ -74758,7 +80623,9 @@ + + @@ -74793,7 +80660,9 @@ + + @@ -74828,7 +80697,9 @@ + + @@ -74882,8 +80753,8 @@ - + @@ -74905,6 +80776,7 @@ + @@ -74953,8 +80825,10 @@ + + @@ -74993,6 +80867,7 @@ + @@ -75030,6 +80905,7 @@ + @@ -75071,8 +80947,10 @@ + + @@ -75111,7 +80989,9 @@ + + @@ -75150,6 +81030,7 @@ + @@ -75190,6 +81071,7 @@ + @@ -75230,6 +81112,7 @@ + @@ -75267,6 +81150,7 @@ + @@ -75302,6 +81186,7 @@ + @@ -75341,6 +81226,7 @@ + @@ -75382,6 +81268,7 @@ + @@ -75423,6 +81310,7 @@ + @@ -75466,6 +81354,7 @@ + @@ -75661,6 +81550,7 @@ + @@ -75741,6 +81631,7 @@ + @@ -75784,6 +81675,7 @@ + @@ -75827,6 +81719,7 @@ + @@ -75869,6 +81762,7 @@ + @@ -75911,6 +81805,7 @@ + @@ -75948,6 +81843,7 @@ + @@ -75994,6 +81890,7 @@ + @@ -76039,6 +81936,7 @@ + @@ -76083,6 +81981,7 @@ + @@ -76125,6 +82024,7 @@ + @@ -76164,6 +82064,7 @@ + @@ -76194,6 +82095,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR124423 (PR #220)

 @@ -76201,6 +82103,7 @@ + @@ -76235,6 +82138,7 @@ + @@ -76273,6 +82177,7 @@ + @@ -76316,6 +82221,7 @@ + @@ -76350,6 +82256,7 @@

Confidence Level: 3

+

NOTES: model.S(601,584) curated (PR #222)

 @@ -76362,6 +82269,7 @@ + @@ -76380,7 +82288,6 @@ - @@ -76392,6 +82299,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR124973 (PR #220)

 @@ -76399,6 +82307,7 @@ + @@ -76441,6 +82350,7 @@ + @@ -76484,6 +82394,7 @@ + @@ -76522,6 +82433,7 @@ + @@ -76558,6 +82470,7 @@ + @@ -76603,6 +82516,7 @@ + @@ -76646,6 +82560,7 @@ + @@ -76681,6 +82596,7 @@ + @@ -76718,6 +82634,7 @@ + @@ -76754,6 +82671,7 @@ + @@ -76790,6 +82708,7 @@ + @@ -76826,6 +82745,7 @@ + @@ -76857,6 +82777,7 @@

Confidence Level: 3

+

NOTES: model.S(604,597) curated (PR #222)

 @@ -76889,6 +82810,7 @@ + @@ -76908,6 +82830,7 @@

Confidence Level: 3

+

NOTES: model.S(604,598) curated (PR #222)

 @@ -76939,6 +82862,7 @@ + @@ -76958,6 +82882,7 @@

Confidence Level: 3

+

NOTES: model.S(604,599) curated (PR #222)

 @@ -76989,6 +82914,7 @@ + @@ -77008,6 +82934,7 @@

Confidence Level: 3

+

NOTES: model.S(604,600) curated (PR #222)

 @@ -77039,6 +82966,7 @@ + @@ -77058,6 +82986,7 @@

Confidence Level: 3

+

NOTES: model.S(604,601) curated (PR #222)

 @@ -77089,6 +83018,7 @@ + @@ -77108,6 +83038,7 @@

Confidence Level: 3

+

NOTES: model.S(604,602) curated (PR #222)

 @@ -77139,6 +83070,7 @@ + @@ -77158,6 +83090,7 @@

Confidence Level: 3

+

NOTES: model.S(604,603) curated (PR #222)

 @@ -77189,6 +83122,7 @@ + @@ -77208,6 +83142,7 @@

Confidence Level: 3

+

NOTES: model.S(604,604) curated (PR #222)

 @@ -77239,6 +83174,7 @@ + @@ -77258,6 +83194,7 @@

Confidence Level: 3

+

NOTES: model.S(604,605) curated (PR #222)

 @@ -77289,6 +83226,7 @@ + @@ -77308,6 +83246,7 @@

Confidence Level: 3

+

NOTES: model.S(604,606) curated (PR #222)

 @@ -77339,6 +83278,7 @@ + @@ -77370,6 +83310,7 @@ + @@ -77409,6 +83350,7 @@ + @@ -77442,6 +83384,7 @@ + @@ -77474,6 +83417,7 @@

Confidence Level: 3

+

NOTES: alternative MetaNetX ID MNXR124394 (PR #220)

 @@ -77486,6 +83430,7 @@ + @@ -77523,6 +83468,7 @@ + @@ -77569,6 +83515,7 @@ + @@ -77599,6 +83546,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -77612,6 +83560,7 @@ + @@ -77649,7 +83598,9 @@ + + @@ -77690,6 +83641,7 @@ + @@ -77736,6 +83688,7 @@ + @@ -77831,7 +83784,9 @@ + + @@ -77877,6 +83832,7 @@ + @@ -77921,6 +83877,7 @@ + @@ -78053,6 +84010,7 @@ + @@ -78089,6 +84047,7 @@ + @@ -78126,6 +84085,7 @@ + @@ -78163,7 +84123,9 @@ + + @@ -78203,6 +84165,7 @@ + @@ -78244,6 +84207,7 @@ + @@ -78290,6 +84254,7 @@ + @@ -78336,6 +84301,7 @@ + @@ -78377,6 +84343,7 @@ + @@ -78415,6 +84382,7 @@ + @@ -78458,6 +84426,7 @@ + @@ -78500,6 +84469,7 @@ + @@ -78542,6 +84512,7 @@ + @@ -78579,6 +84550,7 @@ + @@ -78616,6 +84588,7 @@ + @@ -78653,6 +84626,7 @@ + @@ -78690,6 +84664,7 @@ + @@ -78726,6 +84701,7 @@ + @@ -78762,6 +84738,7 @@ + @@ -78798,6 +84775,7 @@ + @@ -78834,6 +84812,7 @@ + @@ -78870,6 +84849,7 @@ + @@ -78906,6 +84886,7 @@ + @@ -78942,6 +84923,7 @@ + @@ -78978,6 +84960,7 @@ + @@ -79019,7 +85002,9 @@ + + @@ -79064,6 +85049,7 @@ + @@ -79101,6 +85087,7 @@ + @@ -79138,7 +85125,9 @@ + + @@ -79174,6 +85163,7 @@ + @@ -79211,6 +85201,7 @@ + @@ -79252,6 +85243,7 @@ + @@ -79283,6 +85275,7 @@

Confidence Level: 3

+

NOTES: model.S(601,655) curated (PR #222)

 @@ -79295,6 +85288,7 @@ + @@ -79315,7 +85309,6 @@ - @@ -79338,6 +85331,7 @@ + @@ -79379,7 +85373,9 @@ + + @@ -79415,7 +85411,9 @@ + + @@ -79450,8 +85448,10 @@ + + @@ -79486,7 +85486,9 @@ + + @@ -79521,6 +85523,7 @@ + @@ -79560,6 +85563,7 @@ + @@ -79601,9 +85605,11 @@ + + @@ -79647,9 +85653,11 @@ + + @@ -79694,6 +85702,7 @@ + @@ -79731,6 +85740,7 @@ + @@ -79768,6 +85778,7 @@ + @@ -79853,6 +85864,7 @@ + @@ -79894,6 +85906,7 @@ + @@ -79936,6 +85949,7 @@ + @@ -79977,6 +85991,7 @@ + @@ -80019,6 +86034,7 @@ + @@ -80048,6 +86064,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -80061,10 +86078,11 @@ + - + @@ -80103,6 +86121,7 @@ + @@ -80149,6 +86168,7 @@ + @@ -80180,6 +86200,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -80192,9 +86213,10 @@ + - + @@ -80221,6 +86243,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXR108734 (PR #220) | model.S(601,678) curated (PR #222)

 @@ -80228,10 +86251,11 @@ + - + @@ -80249,7 +86273,7 @@ - + @@ -80299,6 +86323,7 @@

Confidence Level: 3

+

NOTES: model.S(601,680) curated (PR #222)

 @@ -80311,6 +86336,7 @@ + @@ -80329,7 +86355,7 @@ - + @@ -80357,6 +86383,7 @@ + @@ -80394,6 +86421,7 @@ + @@ -80436,6 +86464,7 @@ + @@ -80479,6 +86508,7 @@ + @@ -80528,6 +86558,7 @@ + @@ -80570,6 +86601,7 @@ + @@ -80615,6 +86647,7 @@ + @@ -80654,6 +86687,7 @@ + @@ -80700,6 +86734,7 @@ + @@ -80741,6 +86776,7 @@ + @@ -80778,6 +86814,7 @@ + @@ -80817,6 +86854,7 @@ + @@ -80858,6 +86896,7 @@ + @@ -80894,6 +86933,7 @@ + @@ -80933,6 +86973,7 @@ + @@ -80984,6 +87025,7 @@ + @@ -81015,6 +87057,7 @@

Confidence Level: 2

+

NOTES: model.S(601,697) curated (PR #222)

 @@ -81022,6 +87065,7 @@ + @@ -81043,7 +87087,7 @@ - + @@ -81066,6 +87110,7 @@ + @@ -81103,6 +87148,7 @@ + @@ -81135,6 +87181,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR136160 (PR #220) | KEGG ID curated (PR #220) | alternative KEGG ID "R07404, R7405" (PR #220) | model.S(288,700) curated (PR #222) | model.S(324,700) curated (PR #222) | model.S(610,700) curated (PR #222) | model.S(1035,700) curated (PR #222)

 @@ -81157,14 +87204,10 @@ - - - - @@ -81182,6 +87225,7 @@ + @@ -81227,6 +87271,7 @@ + @@ -81261,6 +87306,7 @@ + @@ -81301,6 +87347,7 @@ + @@ -81344,6 +87391,7 @@ + @@ -81406,6 +87454,7 @@ + @@ -81447,6 +87496,7 @@ + @@ -81476,6 +87526,7 @@

Confidence Level: 3

+

NOTES: model.S(611,708) curated (PR #222)

 @@ -81507,6 +87558,7 @@ + @@ -81516,6 +87568,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXR110323 (PR #220) | model.S(611,709) curated (PR #222)

 @@ -81525,7 +87578,7 @@ - + @@ -81542,6 +87595,7 @@ + @@ -81591,6 +87645,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXR110321 (PR #220)

 @@ -81606,7 +87661,7 @@ - + @@ -81648,6 +87703,7 @@ + @@ -81685,6 +87741,7 @@ + @@ -81726,7 +87783,9 @@ + + @@ -81768,7 +87827,9 @@ + + @@ -81798,6 +87859,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -81810,9 +87872,10 @@ + - + @@ -81852,6 +87915,7 @@ + @@ -81890,6 +87954,7 @@ + @@ -81917,6 +87982,7 @@

Confidence Level: 2

+

NOTES: model.S(601,719) curated (PR #222)

 @@ -81924,6 +87990,7 @@ + @@ -81945,7 +88012,6 @@ - @@ -81963,6 +88029,7 @@ + @@ -82004,9 +88071,11 @@ + + @@ -82051,7 +88120,9 @@ + + @@ -82091,7 +88162,9 @@ + + @@ -82131,7 +88204,9 @@ + + @@ -82166,6 +88241,7 @@ + @@ -82203,7 +88279,9 @@ + + @@ -82240,6 +88318,7 @@ + @@ -82276,6 +88355,7 @@ + @@ -82312,7 +88392,9 @@ + + @@ -82348,6 +88430,7 @@ + @@ -82390,6 +88473,7 @@ + @@ -82438,6 +88522,7 @@ + @@ -82486,6 +88571,7 @@ + @@ -82537,6 +88623,7 @@ + @@ -82626,6 +88713,7 @@ + @@ -82663,6 +88751,7 @@ + @@ -82693,6 +88782,7 @@

Confidence Level: 2

+

NOTES: model.S(601,738) curated (PR #222)

 @@ -82700,6 +88790,7 @@ + @@ -82719,6 +88810,7 @@ + @@ -82730,6 +88822,7 @@

Confidence Level: 2

+

NOTES: model.S(601,739) curated (PR #222)

 @@ -82737,6 +88830,7 @@ + @@ -82752,6 +88846,7 @@ + @@ -82765,6 +88860,7 @@

Confidence Level: 3

+

NOTES: KEGG ID curated (PR #220)

 @@ -82777,7 +88873,9 @@ + + @@ -82806,6 +88904,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137376 (PR #220) | model.S(601,741) curated (PR #222)

 @@ -82813,6 +88912,7 @@ + @@ -82827,6 +88927,7 @@ + @@ -82842,6 +88943,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137378 (PR #220) | model.S(601,742) curated (PR #222)

 @@ -82849,6 +88951,7 @@ + @@ -82863,6 +88966,7 @@ + @@ -82878,6 +88982,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137377 (PR #220) | model.S(601,743) curated (PR #222)

 @@ -82885,6 +88990,7 @@ + @@ -82899,6 +89005,7 @@ + @@ -82914,6 +89021,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137379 (PR #220) | model.S(601,744) curated (PR #222)

 @@ -82921,6 +89029,7 @@ + @@ -82934,6 +89043,7 @@ + @@ -82950,6 +89060,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137337 (PR #220) | model.S(601,745) curated (PR #222)

 @@ -82957,6 +89068,7 @@ + @@ -82972,6 +89084,7 @@ + @@ -82992,6 +89105,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137337 (PR #220) | model.S(607,746) curated (PR #222)

 @@ -82999,6 +89113,7 @@ + @@ -83014,6 +89129,7 @@ + @@ -83034,6 +89150,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137339 (PR #220) | model.S(601,747) curated (PR #222)

 @@ -83041,6 +89158,7 @@ + @@ -83056,6 +89174,7 @@ + @@ -83076,6 +89195,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137339 (PR #220) | model.S(607,748) curated (PR #222)

 @@ -83083,6 +89203,7 @@ + @@ -83098,6 +89219,7 @@ + @@ -83118,6 +89240,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137338 (PR #220) | model.S(601,749) curated (PR #222)

 @@ -83125,6 +89248,7 @@ + @@ -83140,6 +89264,7 @@ + @@ -83160,6 +89285,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137338 (PR #220) | model.S(607,750) curated (PR #222)

 @@ -83167,6 +89293,7 @@ + @@ -83182,6 +89309,7 @@ + @@ -83214,6 +89342,7 @@ + @@ -83252,6 +89381,7 @@ + @@ -83295,6 +89425,7 @@ + @@ -83334,6 +89465,7 @@ + @@ -83383,6 +89515,7 @@ + @@ -83420,6 +89553,7 @@ + @@ -83462,6 +89596,7 @@ + @@ -83506,6 +89641,7 @@ + @@ -83545,6 +89681,7 @@ + @@ -83585,6 +89722,7 @@ + @@ -83623,6 +89761,7 @@

Confidence Level: 3

+

NOTES: model.S(602,761) curated (PR #222)

 @@ -83652,6 +89791,7 @@ + @@ -83690,6 +89830,7 @@ + @@ -83736,6 +89877,7 @@ + @@ -83782,6 +89924,7 @@ + @@ -83816,6 +89959,7 @@

Confidence Level: 3

+

NOTES: model.S(601,765) curated (PR #222)

 @@ -83828,8 +89972,10 @@ + + @@ -83846,7 +89992,7 @@ - + @@ -83858,6 +90004,7 @@

Confidence Level: 3

+

NOTES: model.S(601,766) curated (PR #222)

 @@ -83870,6 +90017,7 @@ + @@ -83889,7 +90037,7 @@ - + @@ -83900,6 +90048,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXR99636 (PR #220) | model.S(601,767) curated (PR #222)

 @@ -83915,7 +90064,7 @@ - + @@ -83932,6 +90081,7 @@ + @@ -83949,6 +90099,7 @@ + @@ -83986,6 +90137,7 @@ + @@ -84029,6 +90181,7 @@ + @@ -84071,6 +90224,7 @@ + @@ -84116,6 +90270,7 @@ + @@ -84286,6 +90441,7 @@ + @@ -84321,6 +90477,7 @@ + @@ -84364,6 +90521,7 @@ + @@ -84403,6 +90561,7 @@ + @@ -84446,6 +90605,7 @@ + @@ -84505,6 +90665,7 @@ + @@ -84551,6 +90712,7 @@ + @@ -84589,6 +90751,7 @@ + @@ -84630,6 +90793,7 @@ + @@ -84672,6 +90836,7 @@ + @@ -84703,6 +90868,7 @@

Confidence Level: 2

+

NOTES: model.S(601,786) curated (PR #222)

 @@ -84710,7 +90876,9 @@ + + @@ -84723,7 +90891,7 @@ - + @@ -84755,7 +90923,9 @@ + + @@ -84794,9 +90964,11 @@ + + @@ -84829,6 +91001,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -84842,9 +91015,10 @@ + - + @@ -84877,6 +91051,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -84884,8 +91059,9 @@ + - + @@ -84920,6 +91096,7 @@ + @@ -84956,6 +91133,7 @@ + @@ -84993,6 +91171,7 @@ + @@ -85029,6 +91208,7 @@ + @@ -85060,6 +91240,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | model.S(607,795) curated (PR #222)

 @@ -85072,7 +91253,9 @@ + + @@ -85084,6 +91267,7 @@ + @@ -85108,6 +91292,7 @@

Confidence Level: 2

+

NOTES: alternative MetaNetX ID MNXR137353 (PR #220) | model.S(601,796) curated (PR #222)

 @@ -85115,6 +91300,7 @@ + @@ -85129,7 +91315,6 @@ - @@ -85155,6 +91340,7 @@

Confidence Level: 3

+

NOTES: alternative MetaNetX ID MNXR137353 (PR #220) | model.S(606,797) curated (PR #222)

 @@ -85167,6 +91353,7 @@ + @@ -85182,7 +91369,6 @@ - @@ -85219,6 +91405,7 @@ + @@ -85259,6 +91446,7 @@ + @@ -85300,6 +91488,7 @@ + @@ -85343,6 +91532,7 @@ + @@ -85381,6 +91571,7 @@ + @@ -85422,6 +91613,7 @@ + @@ -85463,6 +91655,7 @@ + @@ -85504,6 +91697,7 @@ + @@ -85547,6 +91741,7 @@ + @@ -85585,6 +91780,7 @@ + @@ -85628,6 +91824,7 @@ + @@ -85681,7 +91878,9 @@ + + @@ -85719,6 +91918,7 @@ + @@ -85761,6 +91961,7 @@ + @@ -85803,6 +92004,7 @@ + @@ -85846,6 +92048,7 @@ + @@ -85890,6 +92093,7 @@ + @@ -85927,6 +92131,7 @@ + @@ -85968,6 +92173,7 @@ + @@ -86011,6 +92217,7 @@ + @@ -86054,6 +92261,7 @@ + @@ -86124,6 +92332,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220)

 @@ -86131,9 +92340,11 @@ + - + + @@ -86158,6 +92369,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -86165,9 +92377,10 @@ + - + @@ -86201,6 +92414,7 @@ + @@ -86237,6 +92451,7 @@ + @@ -86273,6 +92488,7 @@ + @@ -86309,6 +92525,7 @@ + @@ -86354,7 +92571,9 @@ + + @@ -86391,6 +92610,7 @@ + @@ -86431,6 +92651,7 @@ + @@ -86471,6 +92692,7 @@ + @@ -86507,6 +92729,7 @@ + @@ -86543,6 +92766,7 @@ + @@ -86579,6 +92803,7 @@ + @@ -86616,6 +92841,7 @@ + @@ -86644,6 +92870,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -86656,9 +92883,10 @@ + - + @@ -86701,6 +92929,7 @@ + @@ -86742,6 +92971,7 @@ + @@ -86783,6 +93013,7 @@ + @@ -86826,6 +93057,7 @@ + @@ -86864,6 +93096,7 @@ + @@ -86900,6 +93133,7 @@ + @@ -86937,6 +93171,7 @@ + @@ -86975,6 +93210,7 @@ + @@ -87059,6 +93295,8 @@ + + @@ -87086,6 +93324,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -87094,7 +93333,8 @@ - + + @@ -87133,7 +93373,9 @@ + + @@ -87162,6 +93404,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | alternative MetaNetX ID MNXR99596 (PR #220) | model.S(610,847) curated (PR #222)

 @@ -87176,7 +93419,7 @@ - + @@ -87192,6 +93435,7 @@ + @@ -87203,6 +93447,7 @@

Confidence Level: 0

+

NOTES: MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220) | model.S(951,848) curated (PR #222) | model.S(955,848) curated (PR #222) | model.S(610,848) curated (PR #222) | model.S(601,848) curated (PR #222)

 @@ -87213,6 +93458,12 @@ + + + + + + @@ -87222,9 +93473,13 @@ + + + + @@ -87232,6 +93487,7 @@

Confidence Level: 0

+

NOTES: model.S(601,849) curated (PR #222)

 @@ -87244,6 +93500,7 @@ + @@ -87259,6 +93516,7 @@ + @@ -87279,6 +93537,7 @@ + @@ -87312,6 +93571,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220) | model.S(601,851) curated (PR #222)

 @@ -87320,8 +93580,8 @@ - - + + @@ -87339,7 +93599,7 @@ - + @@ -87355,6 +93615,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220)

 @@ -87368,10 +93629,10 @@ - + - - + + @@ -87411,6 +93672,7 @@ + @@ -87484,6 +93746,7 @@

Confidence Level: 3

+

NOTES: model.S(610,855) curated (PR #222)

 @@ -87511,6 +93774,7 @@ + @@ -87538,6 +93802,7 @@ + @@ -87674,6 +93939,7 @@ + @@ -87806,6 +94072,7 @@ + @@ -87846,6 +94113,7 @@ + @@ -87874,6 +94142,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -87887,6 +94156,7 @@ + @@ -87964,6 +94234,7 @@ + @@ -87990,6 +94261,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -88003,6 +94275,7 @@ + @@ -88245,6 +94518,7 @@ + @@ -88542,6 +94816,7 @@ + @@ -88652,6 +94927,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -88665,7 +94941,7 @@ - + @@ -88746,6 +95022,7 @@ + @@ -88823,6 +95100,7 @@ + @@ -88925,6 +95203,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -88938,6 +95217,7 @@ + @@ -89014,6 +95294,7 @@ + @@ -89095,6 +95376,7 @@ + @@ -89468,6 +95750,7 @@ + @@ -89735,6 +96018,7 @@ + @@ -89914,6 +96198,7 @@ + @@ -90430,6 +96715,7 @@

Confidence Level: 3

+

NOTES: model.S(608,926) curated (PR #222)

 @@ -90459,7 +96745,7 @@ - + @@ -90470,6 +96756,7 @@

Confidence Level: 3

+

NOTES: model.S(608,927) curated (PR #222)

 @@ -90482,6 +96769,7 @@ + @@ -90500,7 +96788,7 @@ - + @@ -90565,6 +96853,7 @@ + @@ -90593,6 +96882,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -90605,7 +96895,9 @@ + + @@ -90632,6 +96924,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -90644,7 +96937,9 @@ + + @@ -90788,6 +97083,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -90800,7 +97096,9 @@ + + @@ -90827,6 +97125,7 @@

Confidence Level: 3

+

NOTES: model.S(608,936) curated (PR #222)

 @@ -90851,6 +97150,7 @@ + @@ -91073,8 +97373,10 @@ + + @@ -91113,8 +97415,10 @@ + + @@ -91153,8 +97457,10 @@ + + @@ -91193,8 +97499,10 @@ + + @@ -91233,8 +97541,10 @@ + + @@ -91300,6 +97610,7 @@

Confidence Level: 3

+

NOTES: model.S(608,948) curated (PR #222)

 @@ -91329,6 +97640,7 @@ + @@ -91378,6 +97690,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220) | model.S(608,950) curated (PR #222)

 @@ -91392,6 +97705,7 @@ + @@ -91403,6 +97717,7 @@ + @@ -91495,6 +97810,7 @@

Confidence Level: 3

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -91509,6 +97825,7 @@ + @@ -91651,6 +97968,7 @@

Confidence Level: 3

+

NOTES: model.S(608,957) curated (PR #222)

 @@ -91676,6 +97994,7 @@ + @@ -91780,8 +98099,10 @@ + + @@ -91822,8 +98143,10 @@ + + @@ -91864,8 +98187,10 @@ + + @@ -91906,6 +98231,7 @@ + @@ -92481,7 +98807,9 @@ + + @@ -92520,6 +98848,7 @@ + @@ -92559,6 +98888,7 @@ + @@ -92598,6 +98928,7 @@ + @@ -92637,6 +98968,7 @@ + @@ -92676,6 +99008,7 @@ + @@ -92937,6 +99270,7 @@

Confidence Level: 3

+

NOTES: model.S(608,989) curated (PR #222)

 @@ -92964,6 +99298,7 @@ + @@ -93011,6 +99346,7 @@

Confidence Level: 3

+

NOTES: model.S(608,991) curated (PR #222)

 @@ -93023,6 +99359,7 @@ + @@ -93038,6 +99375,7 @@ + @@ -93048,6 +99386,7 @@

Confidence Level: 3

+

NOTES: model.S(608,992) curated (PR #222)

 @@ -93075,6 +99414,7 @@ + @@ -93122,6 +99462,7 @@

Confidence Level: 3

+

NOTES: model.S(608,994) curated (PR #222)

 @@ -93149,6 +99490,7 @@ + @@ -93325,7 +99667,9 @@ + + @@ -93352,6 +99696,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1000) curated (PR #222)

 @@ -93377,6 +99722,7 @@ + @@ -93395,6 +99741,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1001) curated (PR #222)

 @@ -93420,6 +99767,7 @@ + @@ -93438,6 +99786,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1002) curated (PR #222)

 @@ -93463,6 +99812,7 @@ + @@ -93478,6 +99828,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1003) curated (PR #222)

 @@ -93503,6 +99854,7 @@ + @@ -93518,6 +99870,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1004) curated (PR #222)

 @@ -93543,6 +99896,7 @@ + @@ -93561,6 +99915,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1005) curated (PR #222)

 @@ -93586,6 +99941,7 @@ + @@ -93604,6 +99960,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1006) curated (PR #222)

 @@ -93629,6 +99986,7 @@ + @@ -93644,6 +100002,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1007) curated (PR #222)

 @@ -93669,6 +100028,7 @@ + @@ -93684,6 +100044,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1008) curated (PR #222)

 @@ -93710,6 +100071,7 @@ + @@ -93724,6 +100086,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1009) curated (PR #222)

 @@ -93750,6 +100113,7 @@ + @@ -93764,6 +100128,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1010) curated (PR #222)

 @@ -93790,6 +100155,7 @@ + @@ -93804,6 +100170,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1011) curated (PR #222)

 @@ -93830,6 +100197,7 @@ + @@ -93844,6 +100212,7 @@

Confidence Level: 3

+

NOTES: model.S(605,1012) curated (PR #222)

 @@ -93870,6 +100239,7 @@ + @@ -93884,6 +100254,7 @@

Confidence Level: 3

+

NOTES: model.S(605,1013) curated (PR #222)

 @@ -93910,6 +100281,7 @@ + @@ -93924,6 +100296,7 @@

Confidence Level: 3

+

NOTES: model.S(605,1014) curated (PR #222)

 @@ -93950,6 +100323,7 @@ + @@ -93964,6 +100338,7 @@

Confidence Level: 3

+

NOTES: model.S(605,1015) curated (PR #222)

 @@ -93990,6 +100365,7 @@ + @@ -94832,6 +101208,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1036) curated (PR #222)

 @@ -94860,6 +101237,7 @@ + @@ -94871,6 +101249,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1037) curated (PR #222)

 @@ -94899,6 +101278,7 @@ + @@ -94910,6 +101290,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1038) curated (PR #222)

 @@ -94938,6 +101319,7 @@ + @@ -94949,6 +101331,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1039) curated (PR #222)

 @@ -94977,6 +101360,7 @@ + @@ -94988,6 +101372,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1040) curated (PR #222)

 @@ -95016,6 +101401,7 @@ + @@ -95027,6 +101413,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1041) curated (PR #222)

 @@ -95055,6 +101442,7 @@ + @@ -95066,6 +101454,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1042) curated (PR #222)

 @@ -95094,6 +101483,7 @@ + @@ -95105,6 +101495,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1043) curated (PR #222)

 @@ -95133,6 +101524,7 @@ + @@ -95144,6 +101536,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1044) curated (PR #222)

 @@ -95175,6 +101568,7 @@ + @@ -95184,6 +101578,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1045) curated (PR #222)

 @@ -95215,6 +101610,7 @@ + @@ -95224,6 +101620,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1046) curated (PR #222)

 @@ -95255,6 +101652,7 @@ + @@ -95264,6 +101662,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1047) curated (PR #222)

 @@ -95295,6 +101694,7 @@ + @@ -95304,6 +101704,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1048) curated (PR #222)

 @@ -95335,6 +101736,7 @@ + @@ -95344,6 +101746,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1049) curated (PR #222)

 @@ -95375,6 +101778,7 @@ + @@ -95384,6 +101788,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1050) curated (PR #222)

 @@ -95415,6 +101820,7 @@ + @@ -95424,6 +101830,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1051) curated (PR #222)

 @@ -95455,6 +101862,7 @@ + @@ -95464,6 +101872,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1052) curated (PR #222)

 @@ -95495,6 +101904,7 @@ + @@ -95504,6 +101914,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1053) curated (PR #222)

 @@ -95535,6 +101946,7 @@ + @@ -95544,6 +101956,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1054) curated (PR #222)

 @@ -95575,6 +101988,7 @@ + @@ -95584,6 +101998,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1055) curated (PR #222)

 @@ -95615,6 +102030,7 @@ + @@ -95624,6 +102040,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1056) curated (PR #222)

 @@ -95655,6 +102072,7 @@ + @@ -95664,6 +102082,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1057) curated (PR #222)

 @@ -95695,6 +102114,7 @@ + @@ -95704,6 +102124,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1058) curated (PR #222)

 @@ -95735,6 +102156,7 @@ + @@ -95744,6 +102166,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1059) curated (PR #222)

 @@ -95775,6 +102198,7 @@ + @@ -99064,6 +105488,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1138) curated (PR #222)

 @@ -99092,7 +105517,7 @@ - + @@ -99104,6 +105529,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1139) curated (PR #222)

 @@ -99132,7 +105558,7 @@ - + @@ -99144,6 +105570,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1140) curated (PR #222)

 @@ -99172,7 +105599,7 @@ - + @@ -99184,6 +105611,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1141) curated (PR #222)

 @@ -99212,7 +105640,7 @@ - + @@ -99224,6 +105652,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1142) curated (PR #222)

 @@ -99252,7 +105681,7 @@ - + @@ -99264,6 +105693,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1143) curated (PR #222)

 @@ -99292,7 +105722,7 @@ - + @@ -99304,6 +105734,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1144) curated (PR #222)

 @@ -99332,7 +105763,7 @@ - + @@ -99344,6 +105775,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1145) curated (PR #222)

 @@ -99372,7 +105804,7 @@ - + @@ -99384,6 +105816,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1146) curated (PR #222)

 @@ -99412,7 +105845,7 @@ - + @@ -99424,6 +105857,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1147) curated (PR #222)

 @@ -99452,7 +105886,7 @@ - + @@ -99464,6 +105898,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1148) curated (PR #222)

 @@ -99492,7 +105927,7 @@ - + @@ -99504,6 +105939,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1149) curated (PR #222)

 @@ -99532,7 +105968,7 @@ - + @@ -99544,6 +105980,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1150) curated (PR #222)

 @@ -99572,7 +106009,7 @@ - + @@ -99584,6 +106021,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1151) curated (PR #222)

 @@ -99612,7 +106050,7 @@ - + @@ -99624,6 +106062,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1152) curated (PR #222)

 @@ -99652,7 +106091,7 @@ - + @@ -99664,6 +106103,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1153) curated (PR #222)

 @@ -99692,7 +106132,7 @@ - + @@ -99782,6 +106222,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1156) curated (PR #222)

 @@ -99806,7 +106247,6 @@ - @@ -99821,6 +106261,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1157) curated (PR #222)

 @@ -99845,7 +106286,6 @@ - @@ -99860,6 +106300,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1158) curated (PR #222)

 @@ -99884,7 +106325,6 @@ - @@ -99899,6 +106339,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1159) curated (PR #222)

 @@ -99923,7 +106364,6 @@ - @@ -99938,6 +106378,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1160) curated (PR #222)

 @@ -99962,7 +106403,6 @@ - @@ -99977,6 +106417,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1161) curated (PR #222)

 @@ -100001,7 +106442,6 @@ - @@ -100016,6 +106456,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1162) curated (PR #222)

 @@ -100040,7 +106481,6 @@ - @@ -100055,6 +106495,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1163) curated (PR #222)

 @@ -100079,7 +106520,6 @@ - @@ -100094,6 +106534,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1164) curated (PR #222)

 @@ -100119,7 +106560,6 @@ - @@ -100133,6 +106573,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1165) curated (PR #222)

 @@ -100157,7 +106598,6 @@ - @@ -100172,6 +106612,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1166) curated (PR #222)

 @@ -100196,7 +106637,6 @@ - @@ -100211,6 +106651,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1167) curated (PR #222)

 @@ -100235,7 +106676,6 @@ - @@ -100250,6 +106690,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1168) curated (PR #222)

 @@ -100274,7 +106715,6 @@ - @@ -100289,6 +106729,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1169) curated (PR #222)

 @@ -100313,7 +106754,6 @@ - @@ -100328,6 +106768,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1170) curated (PR #222)

 @@ -100352,7 +106793,6 @@ - @@ -100367,6 +106807,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1171) curated (PR #222)

 @@ -100391,7 +106832,6 @@ - @@ -100406,6 +106846,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1172) curated (PR #222)

 @@ -100431,7 +106872,6 @@ - @@ -100445,6 +106885,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1173) curated (PR #222)

 @@ -100469,7 +106910,6 @@ - @@ -100484,6 +106924,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1174) curated (PR #222)

 @@ -100508,7 +106949,6 @@ - @@ -100523,6 +106963,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1175) curated (PR #222)

 @@ -100547,7 +106988,6 @@ - @@ -100562,6 +107002,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1176) curated (PR #222)

 @@ -100586,7 +107027,6 @@ - @@ -100601,6 +107041,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1177) curated (PR #222)

 @@ -100625,7 +107066,6 @@ - @@ -100640,6 +107080,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1178) curated (PR #222)

 @@ -100664,7 +107105,6 @@ - @@ -100679,6 +107119,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1179) curated (PR #222)

 @@ -100703,7 +107144,6 @@ - @@ -101726,6 +108166,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1204) curated (PR #222)

 @@ -101750,11 +108191,11 @@ + - @@ -101766,6 +108207,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1205) curated (PR #222)

 @@ -101790,11 +108232,11 @@ + - @@ -101806,6 +108248,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1206) curated (PR #222)

 @@ -101830,11 +108273,11 @@ + - @@ -101846,6 +108289,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1207) curated (PR #222)

 @@ -101870,11 +108314,11 @@ + - @@ -101886,6 +108330,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1208) curated (PR #222)

 @@ -101910,11 +108355,11 @@ + - @@ -101926,6 +108371,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1209) curated (PR #222)

 @@ -101950,11 +108396,11 @@ + - @@ -101966,6 +108412,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1210) curated (PR #222)

 @@ -101990,11 +108437,11 @@ + - @@ -102006,6 +108453,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1211) curated (PR #222)

 @@ -102030,11 +108478,11 @@ + - @@ -102726,6 +109174,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1228) curated (PR #222)

 @@ -102754,7 +109203,6 @@ - @@ -102766,6 +109214,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1229) curated (PR #222)

 @@ -102794,7 +109243,6 @@ - @@ -102806,6 +109254,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1230) curated (PR #222)

 @@ -102834,7 +109283,6 @@ - @@ -102846,6 +109294,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1231) curated (PR #222)

 @@ -102874,7 +109323,6 @@ - @@ -102886,6 +109334,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1232) curated (PR #222)

 @@ -102914,7 +109363,6 @@ - @@ -102926,6 +109374,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1233) curated (PR #222)

 @@ -102954,7 +109403,6 @@ - @@ -102966,6 +109414,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1234) curated (PR #222)

 @@ -102994,6 +109443,7 @@ + @@ -103005,6 +109455,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1235) curated (PR #222)

 @@ -103033,6 +109484,7 @@ + @@ -103044,6 +109496,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1236) curated (PR #222)

 @@ -103072,6 +109525,7 @@ + @@ -103083,6 +109537,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1237) curated (PR #222)

 @@ -103111,6 +109566,7 @@ + @@ -103122,6 +109578,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1238) curated (PR #222)

 @@ -103150,6 +109607,7 @@ + @@ -103161,6 +109619,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1239) curated (PR #222)

 @@ -103189,6 +109648,7 @@ + @@ -103200,6 +109660,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1240) curated (PR #222)

 @@ -103228,7 +109689,7 @@ - + @@ -103240,6 +109701,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1241) curated (PR #222)

 @@ -103268,7 +109730,7 @@ - + @@ -103280,6 +109742,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1242) curated (PR #222)

 @@ -103308,7 +109771,7 @@ - + @@ -103320,6 +109783,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1243) curated (PR #222)

 @@ -103348,7 +109812,7 @@ - + @@ -103360,6 +109824,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1244) curated (PR #222)

 @@ -103388,7 +109853,7 @@ - + @@ -103400,6 +109865,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1245) curated (PR #222)

 @@ -103428,7 +109894,7 @@ - + @@ -103440,6 +109906,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1246) curated (PR #222)

 @@ -103468,7 +109935,7 @@ - + @@ -103480,6 +109947,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1247) curated (PR #222)

 @@ -103508,7 +109976,7 @@ - + @@ -103520,6 +109988,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1248) curated (PR #222)

 @@ -103548,7 +110017,7 @@ - + @@ -103560,6 +110029,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1249) curated (PR #222)

 @@ -103588,7 +110058,7 @@ - + @@ -103600,6 +110070,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1250) curated (PR #222)

 @@ -103628,7 +110099,7 @@ - + @@ -103640,6 +110111,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1251) curated (PR #222)

 @@ -103668,7 +110140,7 @@ - + @@ -103680,6 +110152,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1252) curated (PR #222)

 @@ -103708,7 +110181,7 @@ - + @@ -103720,6 +110193,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1253) curated (PR #222)

 @@ -103748,7 +110222,7 @@ - + @@ -103760,6 +110234,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1254) curated (PR #222)

 @@ -103788,7 +110263,7 @@ - + @@ -103800,6 +110275,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1255) curated (PR #222)

 @@ -103828,7 +110304,7 @@ - + @@ -103840,6 +110316,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1256) curated (PR #222)

 @@ -103868,7 +110345,7 @@ - + @@ -103880,6 +110357,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1257) curated (PR #222)

 @@ -103908,7 +110386,7 @@ - + @@ -103920,6 +110398,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1258) curated (PR #222)

 @@ -103948,7 +110427,7 @@ - + @@ -103960,6 +110439,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1259) curated (PR #222)

 @@ -103988,7 +110468,7 @@ - + @@ -104000,6 +110480,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1260) curated (PR #222)

 @@ -104028,7 +110509,7 @@ - + @@ -104040,6 +110521,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1261) curated (PR #222)

 @@ -104068,7 +110550,7 @@ - + @@ -104080,6 +110562,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1262) curated (PR #222)

 @@ -104108,7 +110591,7 @@ - + @@ -104120,6 +110603,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1263) curated (PR #222)

 @@ -104148,7 +110632,7 @@ - + @@ -104160,6 +110644,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1264) curated (PR #222)

 @@ -104188,7 +110673,7 @@ - + @@ -104200,6 +110685,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1265) curated (PR #222)

 @@ -104228,7 +110714,7 @@ - + @@ -104240,6 +110726,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1266) curated (PR #222)

 @@ -104268,7 +110755,7 @@ - + @@ -104280,6 +110767,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1267) curated (PR #222)

 @@ -104308,7 +110796,7 @@ - + @@ -104320,6 +110808,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1268) curated (PR #222)

 @@ -104348,7 +110837,7 @@ - + @@ -104360,6 +110849,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1269) curated (PR #222)

 @@ -104388,7 +110878,7 @@ - + @@ -104400,6 +110890,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1270) curated (PR #222)

 @@ -104428,7 +110919,7 @@ - + @@ -104440,6 +110931,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1271) curated (PR #222)

 @@ -104468,7 +110960,7 @@ - + @@ -104480,6 +110972,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1272) curated (PR #222)

 @@ -104508,7 +111001,7 @@ - + @@ -104520,6 +111013,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1273) curated (PR #222)

 @@ -104548,7 +111042,7 @@ - + @@ -104560,6 +111054,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1274) curated (PR #222)

 @@ -104588,7 +111083,7 @@ - + @@ -104600,6 +111095,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1275) curated (PR #222)

 @@ -104628,7 +111124,7 @@ - + @@ -113568,6 +120064,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1504) curated (PR #222)

 @@ -113592,11 +120089,11 @@ + - @@ -113611,6 +120108,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1505) curated (PR #222)

 @@ -113635,11 +120133,11 @@ + - @@ -113654,6 +120152,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1506) curated (PR #222)

 @@ -113678,11 +120177,11 @@ + - @@ -113697,6 +120196,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1507) curated (PR #222)

 @@ -113721,11 +120221,11 @@ + - @@ -113740,6 +120240,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1508) curated (PR #222)

 @@ -113764,11 +120265,11 @@ + - @@ -113783,6 +120284,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1509) curated (PR #222)

 @@ -113807,11 +120309,11 @@ + - @@ -113826,6 +120328,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1510) curated (PR #222)

 @@ -113850,11 +120353,11 @@ + - @@ -113869,6 +120372,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1511) curated (PR #222)

 @@ -113893,11 +120397,11 @@ + - @@ -113912,6 +120416,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1512) curated (PR #222)

 @@ -113936,11 +120441,11 @@ + - @@ -113952,6 +120457,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1513) curated (PR #222)

 @@ -113976,11 +120482,11 @@ + - @@ -113992,6 +120498,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1514) curated (PR #222)

 @@ -114016,11 +120523,11 @@ + - @@ -114032,6 +120539,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1515) curated (PR #222)

 @@ -114056,11 +120564,11 @@ + - @@ -114072,6 +120580,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1516) curated (PR #222)

 @@ -114096,11 +120605,11 @@ + - @@ -114112,6 +120621,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1517) curated (PR #222)

 @@ -114136,11 +120646,11 @@ + - @@ -114152,6 +120662,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1518) curated (PR #222)

 @@ -114176,11 +120687,11 @@ + - @@ -114192,6 +120703,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1519) curated (PR #222)

 @@ -114216,11 +120728,11 @@ + - @@ -114232,6 +120744,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1520) curated (PR #222)

 @@ -114256,11 +120769,11 @@ + - @@ -114275,6 +120788,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1521) curated (PR #222)

 @@ -114299,11 +120813,11 @@ + - @@ -114318,6 +120832,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1522) curated (PR #222)

 @@ -114342,11 +120857,11 @@ + - @@ -114361,6 +120876,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1523) curated (PR #222)

 @@ -114385,11 +120901,11 @@ + - @@ -114404,6 +120920,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1524) curated (PR #222)

 @@ -114428,11 +120945,11 @@ + - @@ -114447,6 +120964,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1525) curated (PR #222)

 @@ -114471,11 +120989,11 @@ + - @@ -114490,6 +121008,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1526) curated (PR #222)

 @@ -114514,11 +121033,11 @@ + - @@ -114533,6 +121052,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1527) curated (PR #222)

 @@ -114557,11 +121077,11 @@ + - @@ -114576,6 +121096,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1528) curated (PR #222)

 @@ -114601,11 +121122,11 @@ + - @@ -114616,6 +121137,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1529) curated (PR #222)

 @@ -114641,11 +121163,11 @@ + - @@ -114656,6 +121178,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1530) curated (PR #222)

 @@ -114681,11 +121204,11 @@ + - @@ -114696,6 +121219,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1531) curated (PR #222)

 @@ -114721,11 +121245,11 @@ + - @@ -114736,6 +121260,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1532) curated (PR #222)

 @@ -114761,11 +121286,11 @@ + - @@ -114776,6 +121301,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1533) curated (PR #222)

 @@ -114801,11 +121327,11 @@ + - @@ -114816,6 +121342,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1534) curated (PR #222)

 @@ -114841,11 +121368,11 @@ + - @@ -114856,6 +121383,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1535) curated (PR #222)

 @@ -114881,11 +121409,11 @@ + - @@ -114896,6 +121424,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1536) curated (PR #222)

 @@ -114921,11 +121450,11 @@ + - @@ -114940,6 +121469,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1537) curated (PR #222)

 @@ -114965,11 +121495,11 @@ + - @@ -114984,6 +121514,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1538) curated (PR #222)

 @@ -115009,11 +121540,11 @@ + - @@ -115028,6 +121559,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1539) curated (PR #222)

 @@ -115053,11 +121585,11 @@ + - @@ -115072,6 +121604,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1540) curated (PR #222)

 @@ -115097,11 +121630,11 @@ + - @@ -115116,6 +121649,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1541) curated (PR #222)

 @@ -115141,11 +121675,11 @@ + - @@ -115160,6 +121694,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1542) curated (PR #222)

 @@ -115185,11 +121720,11 @@ + - @@ -115204,6 +121739,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1543) curated (PR #222)

 @@ -115229,11 +121765,11 @@ + - @@ -115248,6 +121784,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1544) curated (PR #222)

 @@ -115273,11 +121810,11 @@ + - @@ -115288,6 +121825,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1545) curated (PR #222)

 @@ -115313,11 +121851,11 @@ + - @@ -115328,6 +121866,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1546) curated (PR #222)

 @@ -115353,11 +121892,11 @@ + - @@ -115368,6 +121907,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1547) curated (PR #222)

 @@ -115393,11 +121933,11 @@ + - @@ -115408,6 +121948,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1548) curated (PR #222)

 @@ -115433,11 +121974,11 @@ + - @@ -115448,6 +121989,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1549) curated (PR #222)

 @@ -115473,11 +122015,11 @@ + - @@ -115488,6 +122030,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1550) curated (PR #222)

 @@ -115513,11 +122056,11 @@ + - @@ -115528,6 +122071,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1551) curated (PR #222)

 @@ -115553,11 +122097,11 @@ + - @@ -115568,6 +122112,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1552) curated (PR #222)

 @@ -115592,11 +122137,11 @@ + - @@ -115608,6 +122153,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1553) curated (PR #222)

 @@ -115632,11 +122178,11 @@ + - @@ -115648,6 +122194,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1554) curated (PR #222)

 @@ -115672,11 +122219,11 @@ + - @@ -115688,6 +122235,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1555) curated (PR #222)

 @@ -115712,11 +122260,11 @@ + - @@ -115728,6 +122276,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1556) curated (PR #222)

 @@ -115752,11 +122301,11 @@ + - @@ -115768,6 +122317,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1557) curated (PR #222)

 @@ -115792,11 +122342,11 @@ + - @@ -115808,6 +122358,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1558) curated (PR #222)

 @@ -115832,11 +122383,11 @@ + - @@ -115848,6 +122399,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1559) curated (PR #222)

 @@ -115872,11 +122424,11 @@ + - @@ -115888,6 +122440,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1560) curated (PR #222)

 @@ -115912,11 +122465,11 @@ + - @@ -115928,6 +122481,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1561) curated (PR #222)

 @@ -115952,11 +122506,11 @@ + - @@ -115968,6 +122522,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1562) curated (PR #222)

 @@ -115992,11 +122547,11 @@ + - @@ -116008,6 +122563,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1563) curated (PR #222)

 @@ -116032,11 +122588,11 @@ + - @@ -116048,6 +122604,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1564) curated (PR #222)

 @@ -116072,11 +122629,11 @@ + - @@ -116088,6 +122645,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1565) curated (PR #222)

 @@ -116112,11 +122670,11 @@ + - @@ -116128,6 +122686,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1566) curated (PR #222)

 @@ -116152,11 +122711,11 @@ + - @@ -116168,6 +122727,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1567) curated (PR #222)

 @@ -116192,11 +122752,11 @@ + - @@ -123512,6 +130072,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1752) curated (PR #222)

 @@ -123540,7 +130101,7 @@ - + @@ -123552,6 +130113,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1753) curated (PR #222)

 @@ -123580,7 +130142,7 @@ - + @@ -123592,6 +130154,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1754) curated (PR #222)

 @@ -123620,7 +130183,7 @@ - + @@ -123632,6 +130195,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1755) curated (PR #222)

 @@ -123660,7 +130224,7 @@ - + @@ -123672,6 +130236,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1756) curated (PR #222)

 @@ -123700,7 +130265,7 @@ - + @@ -123712,6 +130277,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1757) curated (PR #222)

 @@ -123740,7 +130306,7 @@ - + @@ -123752,6 +130318,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1758) curated (PR #222)

 @@ -123780,7 +130347,7 @@ - + @@ -123792,6 +130359,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1759) curated (PR #222)

 @@ -123820,7 +130388,7 @@ - + @@ -123832,6 +130400,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1760) curated (PR #222)

 @@ -123860,7 +130429,7 @@ - + @@ -123872,6 +130441,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1761) curated (PR #222)

 @@ -123900,7 +130470,7 @@ - + @@ -123912,6 +130482,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1762) curated (PR #222)

 @@ -123940,7 +130511,7 @@ - + @@ -123952,6 +130523,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1763) curated (PR #222)

 @@ -123980,7 +130552,7 @@ - + @@ -123992,6 +130564,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1764) curated (PR #222)

 @@ -124021,7 +130594,7 @@ - + @@ -124032,6 +130605,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1765) curated (PR #222)

 @@ -124061,7 +130635,7 @@ - + @@ -124072,6 +130646,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1766) curated (PR #222)

 @@ -124101,7 +130676,7 @@ - + @@ -124112,6 +130687,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1767) curated (PR #222)

 @@ -124141,7 +130717,7 @@ - + @@ -124152,6 +130728,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1768) curated (PR #222)

 @@ -124181,7 +130758,7 @@ - + @@ -124192,6 +130769,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1769) curated (PR #222)

 @@ -124221,7 +130799,7 @@ - + @@ -124232,6 +130810,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1770) curated (PR #222)

 @@ -124261,7 +130840,7 @@ - + @@ -124272,6 +130851,7 @@

Confidence Level: 3

+

NOTES: model.S(607,1771) curated (PR #222)

 @@ -124301,7 +130881,7 @@ - + @@ -124312,6 +130892,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1772) curated (PR #222)

 @@ -124340,7 +130921,7 @@ - + @@ -124352,6 +130933,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1773) curated (PR #222)

 @@ -124380,7 +130962,7 @@ - + @@ -124392,6 +130974,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1774) curated (PR #222)

 @@ -124420,7 +131003,7 @@ - + @@ -124432,6 +131015,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1775) curated (PR #222)

 @@ -124460,7 +131044,7 @@ - + @@ -124472,6 +131056,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1776) curated (PR #222)

 @@ -124500,7 +131085,7 @@ - + @@ -124512,6 +131097,7 @@

Confidence Level: 3

+

NOTES: model.S(1588,1777) curated (PR #222)

 @@ -124540,7 +131126,7 @@ - + @@ -124552,6 +131138,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1778) curated (PR #222)

 @@ -124576,12 +131163,12 @@ + - @@ -124592,6 +131179,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1779) curated (PR #222)

 @@ -124616,12 +131204,12 @@ + - @@ -124632,6 +131220,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1780) curated (PR #222)

 @@ -124656,12 +131245,12 @@ + - @@ -124672,6 +131261,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1781) curated (PR #222)

 @@ -124696,12 +131286,12 @@ + - @@ -124712,6 +131302,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1782) curated (PR #222)

 @@ -124736,12 +131327,12 @@ + - @@ -124752,6 +131343,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1783) curated (PR #222)

 @@ -124776,12 +131368,12 @@ + - @@ -124792,6 +131384,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1784) curated (PR #222)

 @@ -124816,12 +131409,12 @@ + - @@ -124832,6 +131425,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1785) curated (PR #222)

 @@ -124856,12 +131450,12 @@ + - @@ -124872,6 +131466,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1786) curated (PR #222)

 @@ -124901,6 +131496,7 @@ + @@ -124915,6 +131511,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1787) curated (PR #222)

 @@ -124944,6 +131541,7 @@ + @@ -124958,6 +131556,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1788) curated (PR #222)

 @@ -124987,6 +131586,7 @@ + @@ -125001,6 +131601,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1789) curated (PR #222)

 @@ -125030,6 +131631,7 @@ + @@ -125044,6 +131646,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1790) curated (PR #222)

 @@ -125073,6 +131676,7 @@ + @@ -125087,6 +131691,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1791) curated (PR #222)

 @@ -125116,6 +131721,7 @@ + @@ -125130,6 +131736,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1792) curated (PR #222)

 @@ -125159,6 +131766,7 @@ + @@ -125173,6 +131781,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1793) curated (PR #222)

 @@ -125202,6 +131811,7 @@ + @@ -125216,6 +131826,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1794) curated (PR #222)

 @@ -125246,6 +131857,7 @@ + @@ -125261,6 +131873,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1795) curated (PR #222)

 @@ -125273,6 +131886,7 @@ + @@ -125291,6 +131905,7 @@ + @@ -125306,6 +131921,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1796) curated (PR #222)

 @@ -125336,6 +131952,7 @@ + @@ -125351,6 +131968,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1797) curated (PR #222)

 @@ -125381,6 +131999,7 @@ + @@ -125396,6 +132015,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1798) curated (PR #222)

 @@ -125426,6 +132046,7 @@ + @@ -125441,6 +132062,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1799) curated (PR #222)

 @@ -125471,6 +132093,7 @@ + @@ -125486,6 +132109,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1800) curated (PR #222)

 @@ -125516,6 +132140,7 @@ + @@ -125531,6 +132156,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1801) curated (PR #222)

 @@ -125561,6 +132187,7 @@ + @@ -125576,6 +132203,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1802) curated (PR #222)

 @@ -125604,6 +132232,7 @@ + @@ -125615,6 +132244,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1803) curated (PR #222)

 @@ -125643,6 +132273,7 @@ + @@ -125654,6 +132285,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1804) curated (PR #222)

 @@ -125682,6 +132314,7 @@ + @@ -125693,6 +132326,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1805) curated (PR #222)

 @@ -125721,6 +132355,7 @@ + @@ -125732,6 +132367,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1806) curated (PR #222)

 @@ -125760,6 +132396,7 @@ + @@ -125771,6 +132408,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1807) curated (PR #222)

 @@ -125799,6 +132437,7 @@ + @@ -125810,6 +132449,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1808) curated (PR #222)

 @@ -125838,6 +132478,7 @@ + @@ -125849,6 +132490,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1809) curated (PR #222)

 @@ -125877,6 +132519,7 @@ + @@ -125888,6 +132531,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1810) curated (PR #222)

 @@ -125917,6 +132561,7 @@ + @@ -125927,6 +132572,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1811) curated (PR #222)

 @@ -125956,6 +132602,7 @@ + @@ -125966,6 +132613,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1812) curated (PR #222)

 @@ -125995,6 +132643,7 @@ + @@ -126005,6 +132654,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1813) curated (PR #222)

 @@ -126034,6 +132684,7 @@ + @@ -126044,6 +132695,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1814) curated (PR #222)

 @@ -126073,6 +132725,7 @@ + @@ -126083,6 +132736,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1815) curated (PR #222)

 @@ -126112,6 +132766,7 @@ + @@ -126122,6 +132777,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1816) curated (PR #222)

 @@ -126151,6 +132807,7 @@ + @@ -126161,6 +132818,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1817) curated (PR #222)

 @@ -126190,6 +132848,7 @@ + @@ -126200,6 +132859,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1818) curated (PR #222)

 @@ -126229,6 +132889,7 @@ + @@ -126243,6 +132904,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1819) curated (PR #222)

 @@ -126272,6 +132934,7 @@ + @@ -126286,6 +132949,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1820) curated (PR #222)

 @@ -126315,6 +132979,7 @@ + @@ -126329,6 +132994,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1821) curated (PR #222)

 @@ -126358,6 +133024,7 @@ + @@ -126372,6 +133039,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1822) curated (PR #222)

 @@ -126401,6 +133069,7 @@ + @@ -126415,6 +133084,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1823) curated (PR #222)

 @@ -126444,6 +133114,7 @@ + @@ -126458,6 +133129,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1824) curated (PR #222)

 @@ -126487,6 +133159,7 @@ + @@ -126501,6 +133174,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1825) curated (PR #222)

 @@ -126530,6 +133204,7 @@ + @@ -126544,6 +133219,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1826) curated (PR #222)

 @@ -126573,6 +133249,7 @@ + @@ -126587,6 +133264,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1827) curated (PR #222)

 @@ -126616,6 +133294,7 @@ + @@ -126630,6 +133309,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1828) curated (PR #222)

 @@ -126659,6 +133339,7 @@ + @@ -126673,6 +133354,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1829) curated (PR #222)

 @@ -126702,6 +133384,7 @@ + @@ -126716,6 +133399,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1830) curated (PR #222)

 @@ -126745,6 +133429,7 @@ + @@ -126759,6 +133444,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1831) curated (PR #222)

 @@ -126788,6 +133474,7 @@ + @@ -126802,6 +133489,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1832) curated (PR #222)

 @@ -126831,6 +133519,7 @@ + @@ -126845,6 +133534,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1833) curated (PR #222)

 @@ -126874,6 +133564,7 @@ + @@ -126888,6 +133579,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1834) curated (PR #222)

 @@ -126916,6 +133608,7 @@ + @@ -126927,6 +133620,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1835) curated (PR #222)

 @@ -126955,6 +133649,7 @@ + @@ -126966,6 +133661,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1836) curated (PR #222)

 @@ -126994,6 +133690,7 @@ + @@ -127005,6 +133702,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1837) curated (PR #222)

 @@ -127033,6 +133731,7 @@ + @@ -127044,6 +133743,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1838) curated (PR #222)

 @@ -127072,6 +133772,7 @@ + @@ -127083,6 +133784,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1839) curated (PR #222)

 @@ -127111,6 +133813,7 @@ + @@ -127122,6 +133825,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1840) curated (PR #222)

 @@ -127150,6 +133854,7 @@ + @@ -127161,6 +133866,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1841) curated (PR #222)

 @@ -127189,6 +133895,7 @@ + @@ -127200,6 +133907,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1842) curated (PR #222)

 @@ -127229,6 +133937,7 @@ + @@ -127239,6 +133948,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1843) curated (PR #222)

 @@ -127268,6 +133978,7 @@ + @@ -127278,6 +133989,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1844) curated (PR #222)

 @@ -127307,6 +134019,7 @@ + @@ -127317,6 +134030,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1845) curated (PR #222)

 @@ -127346,6 +134060,7 @@ + @@ -127356,6 +134071,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1846) curated (PR #222)

 @@ -127385,6 +134101,7 @@ + @@ -127395,6 +134112,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1847) curated (PR #222)

 @@ -127424,6 +134142,7 @@ + @@ -127434,6 +134153,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1848) curated (PR #222)

 @@ -127463,6 +134183,7 @@ + @@ -127473,6 +134194,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1849) curated (PR #222)

 @@ -127502,6 +134224,7 @@ + @@ -127512,6 +134235,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1850) curated (PR #222)

 @@ -127541,6 +134265,7 @@ + @@ -127555,6 +134280,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1851) curated (PR #222)

 @@ -127584,6 +134310,7 @@ + @@ -127598,6 +134325,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1852) curated (PR #222)

 @@ -127627,6 +134355,7 @@ + @@ -127641,6 +134370,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1853) curated (PR #222)

 @@ -127670,6 +134400,7 @@ + @@ -127684,6 +134415,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1854) curated (PR #222)

 @@ -127713,6 +134445,7 @@ + @@ -127727,6 +134460,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1855) curated (PR #222)

 @@ -127756,6 +134490,7 @@ + @@ -127770,6 +134505,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1856) curated (PR #222)

 @@ -127799,6 +134535,7 @@ + @@ -127813,6 +134550,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1857) curated (PR #222)

 @@ -127842,6 +134580,7 @@ + @@ -127856,6 +134595,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1858) curated (PR #222)

 @@ -127885,6 +134625,7 @@ + @@ -127899,6 +134640,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1859) curated (PR #222)

 @@ -127928,6 +134670,7 @@ + @@ -127942,6 +134685,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1860) curated (PR #222)

 @@ -127971,6 +134715,7 @@ + @@ -127985,6 +134730,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1861) curated (PR #222)

 @@ -128014,6 +134760,7 @@ + @@ -128028,6 +134775,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1862) curated (PR #222)

 @@ -128057,6 +134805,7 @@ + @@ -128071,6 +134820,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1863) curated (PR #222)

 @@ -128100,6 +134850,7 @@ + @@ -128114,6 +134865,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1864) curated (PR #222)

 @@ -128143,6 +134895,7 @@ + @@ -128157,6 +134910,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1865) curated (PR #222)

 @@ -128186,6 +134940,7 @@ + @@ -128200,6 +134955,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1866) curated (PR #222)

 @@ -128229,6 +134985,7 @@ + @@ -128244,6 +135001,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1867) curated (PR #222)

 @@ -128273,6 +135031,7 @@ + @@ -128288,6 +135047,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1868) curated (PR #222)

 @@ -128317,6 +135077,7 @@ + @@ -128332,6 +135093,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1869) curated (PR #222)

 @@ -128361,6 +135123,7 @@ + @@ -128376,6 +135139,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1870) curated (PR #222)

 @@ -128405,6 +135169,7 @@ + @@ -128420,6 +135185,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1871) curated (PR #222)

 @@ -128449,6 +135215,7 @@ + @@ -128464,6 +135231,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1872) curated (PR #222)

 @@ -128493,6 +135261,7 @@ + @@ -128508,6 +135277,7 @@

Confidence Level: 3

+

NOTES: model.S(600,1873) curated (PR #222)

 @@ -128537,6 +135307,7 @@ + @@ -128552,6 +135323,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1874) curated (PR #222)

 @@ -128581,6 +135353,7 @@ + @@ -128596,6 +135369,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1875) curated (PR #222)

 @@ -128625,6 +135399,7 @@ + @@ -128640,6 +135415,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1876) curated (PR #222)

 @@ -128669,6 +135445,7 @@ + @@ -128684,6 +135461,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1877) curated (PR #222)

 @@ -128713,6 +135491,7 @@ + @@ -128728,6 +135507,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1878) curated (PR #222)

 @@ -128757,6 +135537,7 @@ + @@ -128772,6 +135553,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1879) curated (PR #222)

 @@ -128801,6 +135583,7 @@ + @@ -128816,6 +135599,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1880) curated (PR #222)

 @@ -128845,6 +135629,7 @@ + @@ -128860,6 +135645,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1881) curated (PR #222)

 @@ -128889,6 +135675,7 @@ + @@ -128904,6 +135691,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1882) curated (PR #222)

 @@ -128932,6 +135720,7 @@ + @@ -128943,6 +135732,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1883) curated (PR #222)

 @@ -128971,6 +135761,7 @@ + @@ -128982,6 +135773,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1884) curated (PR #222)

 @@ -129010,6 +135802,7 @@ + @@ -129021,6 +135814,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1885) curated (PR #222)

 @@ -129049,6 +135843,7 @@ + @@ -129060,6 +135855,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1886) curated (PR #222)

 @@ -129088,6 +135884,7 @@ + @@ -129099,6 +135896,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1887) curated (PR #222)

 @@ -129127,6 +135925,7 @@ + @@ -129138,6 +135937,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1888) curated (PR #222)

 @@ -129166,6 +135966,7 @@ + @@ -129177,6 +135978,7 @@

Confidence Level: 3

+

NOTES: model.S(1281,1889) curated (PR #222)

 @@ -129205,6 +136007,7 @@ + @@ -129216,6 +136019,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1890) curated (PR #222)

 @@ -129245,6 +136049,7 @@ + @@ -129258,6 +136063,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1891) curated (PR #222)

 @@ -129287,6 +136093,7 @@ + @@ -129300,6 +136107,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1892) curated (PR #222)

 @@ -129329,6 +136137,7 @@ + @@ -129342,6 +136151,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1893) curated (PR #222)

 @@ -129371,6 +136181,7 @@ + @@ -129384,6 +136195,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1894) curated (PR #222)

 @@ -129413,6 +136225,7 @@ + @@ -129426,6 +136239,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1895) curated (PR #222)

 @@ -129455,6 +136269,7 @@ + @@ -129468,6 +136283,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1896) curated (PR #222)

 @@ -129497,6 +136313,7 @@ + @@ -129510,6 +136327,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1897) curated (PR #222)

 @@ -129539,6 +136357,7 @@ + @@ -129552,6 +136371,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1898) curated (PR #222)

 @@ -129583,7 +136403,7 @@ - + @@ -129593,6 +136413,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1899) curated (PR #222)

 @@ -129624,7 +136445,7 @@ - + @@ -129634,6 +136455,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1900) curated (PR #222)

 @@ -129665,7 +136487,7 @@ - + @@ -129675,6 +136497,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1901) curated (PR #222)

 @@ -129706,7 +136529,7 @@ - + @@ -129716,6 +136539,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1902) curated (PR #222)

 @@ -129747,7 +136571,7 @@ - + @@ -129757,6 +136581,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1903) curated (PR #222)

 @@ -129788,7 +136613,7 @@ - + @@ -129798,6 +136623,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1904) curated (PR #222)

 @@ -129829,7 +136655,7 @@ - + @@ -129839,6 +136665,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1905) curated (PR #222)

 @@ -129870,7 +136697,7 @@ - + @@ -129880,6 +136707,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1906) curated (PR #222)

 @@ -129911,7 +136739,7 @@ - + @@ -129921,6 +136749,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1907) curated (PR #222)

 @@ -129952,7 +136781,7 @@ - + @@ -129962,6 +136791,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1908) curated (PR #222)

 @@ -129993,7 +136823,7 @@ - + @@ -130003,6 +136833,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1909) curated (PR #222)

 @@ -130034,7 +136865,7 @@ - + @@ -130044,6 +136875,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1910) curated (PR #222)

 @@ -130075,7 +136907,7 @@ - + @@ -130085,6 +136917,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1911) curated (PR #222)

 @@ -130116,7 +136949,7 @@ - + @@ -130126,6 +136959,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1912) curated (PR #222)

 @@ -130157,7 +136991,7 @@ - + @@ -130167,6 +137001,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1913) curated (PR #222)

 @@ -130198,7 +137033,7 @@ - + @@ -130208,6 +137043,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1914) curated (PR #222)

 @@ -130231,6 +137067,7 @@ + @@ -130242,6 +137079,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1915) curated (PR #222)

 @@ -130265,6 +137103,7 @@ + @@ -130276,6 +137115,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1916) curated (PR #222)

 @@ -130299,6 +137139,7 @@ + @@ -130310,6 +137151,7 @@

Confidence Level: 3

+

NOTES: model.S(601,1917) curated (PR #222)

 @@ -130333,6 +137175,7 @@ + @@ -130344,6 +137187,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1918) curated (PR #222)

 @@ -130374,6 +137218,7 @@ + @@ -130384,6 +137229,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1919) curated (PR #222)

 @@ -130414,6 +137260,7 @@ + @@ -130424,6 +137271,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1920) curated (PR #222)

 @@ -130454,6 +137302,7 @@ + @@ -130464,6 +137313,7 @@

Confidence Level: 3

+

NOTES: model.S(1658,1921) curated (PR #222)

 @@ -130494,6 +137344,7 @@ + @@ -130504,6 +137355,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1922) curated (PR #222)

 @@ -130534,6 +137386,7 @@ + @@ -130544,6 +137397,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1923) curated (PR #222)

 @@ -130574,6 +137428,7 @@ + @@ -130584,6 +137439,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1924) curated (PR #222)

 @@ -130614,6 +137470,7 @@ + @@ -130624,6 +137481,7 @@

Confidence Level: 3

+

NOTES: model.S(1640,1925) curated (PR #222)

 @@ -130654,6 +137512,7 @@ + @@ -134079,6 +140938,7 @@ + @@ -134106,6 +140966,7 @@

Confidence Level: 3

+

NOTES: model.S(612,2007) curated (PR #222)

 @@ -134119,6 +140980,7 @@ + @@ -134131,6 +140993,7 @@ + @@ -134157,7 +141020,9 @@ + + @@ -134397,6 +141262,7 @@ + @@ -134431,6 +141297,7 @@ + @@ -134465,6 +141332,7 @@ + @@ -134500,6 +141368,7 @@ + @@ -134542,6 +141411,7 @@ + @@ -134571,6 +141441,7 @@ + @@ -134608,6 +141479,7 @@ + @@ -134681,6 +141553,7 @@ + @@ -134720,6 +141593,7 @@ + @@ -134781,6 +141655,7 @@ + @@ -134825,6 +141700,7 @@ + @@ -134866,6 +141742,8 @@ + + @@ -134904,6 +141782,7 @@ + @@ -134945,6 +141824,7 @@ + @@ -134979,6 +141859,7 @@ + @@ -135011,6 +141892,7 @@ + @@ -135048,6 +141930,7 @@ + @@ -135085,6 +141968,7 @@ + @@ -135126,6 +142010,7 @@ + @@ -135160,6 +142045,7 @@ + @@ -135194,6 +142080,7 @@ + @@ -135344,6 +142231,7 @@ + @@ -135378,6 +142266,7 @@ + @@ -135412,6 +142301,7 @@ + @@ -135446,6 +142336,7 @@ + @@ -135485,6 +142376,7 @@ + @@ -135558,6 +142450,7 @@ + @@ -135599,6 +142492,7 @@ + @@ -135633,6 +142527,7 @@ + @@ -135672,6 +142567,7 @@ + @@ -135722,6 +142618,7 @@ + @@ -135763,6 +142660,7 @@ + @@ -135802,6 +142700,7 @@ + @@ -135838,6 +142737,7 @@ + @@ -135869,6 +142769,7 @@ + @@ -135924,6 +142825,7 @@ + @@ -135964,6 +142866,7 @@ + @@ -136044,6 +142947,7 @@ + @@ -136081,6 +142985,7 @@ + @@ -136118,6 +143023,7 @@ + @@ -136198,6 +143104,7 @@ + @@ -136232,6 +143139,7 @@ + @@ -136271,6 +143179,7 @@ + @@ -136329,6 +143238,7 @@ + @@ -136406,6 +143316,7 @@ + @@ -136443,6 +143354,7 @@ + @@ -136481,6 +143393,7 @@ + @@ -136519,6 +143432,7 @@ + @@ -136559,6 +143473,7 @@ + @@ -136604,6 +143519,7 @@ + @@ -136638,6 +143554,7 @@ + @@ -136674,6 +143591,7 @@ + @@ -136713,6 +143631,7 @@ + @@ -136755,6 +143674,7 @@ + @@ -136795,6 +143715,7 @@ + @@ -136835,6 +143756,7 @@ + @@ -136869,6 +143791,7 @@ + @@ -136903,6 +143826,7 @@ + @@ -136938,6 +143862,7 @@ + @@ -136980,6 +143905,7 @@ + @@ -137023,6 +143949,7 @@ + @@ -137065,6 +143992,7 @@ + @@ -137109,6 +144037,7 @@ + @@ -137148,6 +144077,7 @@ + @@ -137190,6 +144120,7 @@ + @@ -137224,6 +144155,7 @@ + @@ -137262,6 +144194,7 @@ + @@ -137299,6 +144232,7 @@ + @@ -137346,6 +144280,7 @@ + @@ -137385,6 +144320,7 @@ + @@ -137422,6 +144358,7 @@ + @@ -137456,6 +144393,7 @@ + @@ -137500,6 +144438,7 @@ + @@ -137539,6 +144478,7 @@ + @@ -137576,6 +144516,7 @@ + @@ -137620,6 +144561,7 @@ + @@ -137659,6 +144601,7 @@ + @@ -137739,6 +144682,7 @@ + @@ -137778,6 +144722,7 @@ + @@ -137815,6 +144760,7 @@ + @@ -137860,6 +144806,7 @@ + @@ -137897,6 +144844,7 @@ + @@ -137973,6 +144921,7 @@ + @@ -138012,6 +144961,7 @@ + @@ -138049,6 +144999,7 @@ + @@ -138095,6 +145046,7 @@ + @@ -138134,6 +145086,7 @@ + @@ -138171,6 +145124,7 @@ + @@ -138213,6 +145167,7 @@ + @@ -138253,6 +145208,7 @@ + @@ -138290,6 +145246,7 @@ + @@ -138336,6 +145293,7 @@ + @@ -138381,6 +145339,7 @@ + @@ -138463,6 +145422,7 @@ + @@ -138505,6 +145465,7 @@ + @@ -138542,6 +145503,7 @@ + @@ -138583,6 +145545,7 @@ + @@ -138628,6 +145591,7 @@ + @@ -138663,6 +145627,7 @@ + @@ -138702,6 +145667,7 @@ + @@ -138779,6 +145745,7 @@ + @@ -138921,6 +145888,7 @@ + @@ -138998,6 +145966,7 @@ + @@ -139032,6 +146001,7 @@ + @@ -139069,6 +146039,7 @@ + @@ -139103,6 +146074,7 @@ + @@ -139142,6 +146114,7 @@ + @@ -139176,6 +146149,7 @@ + @@ -139205,6 +146179,7 @@ + @@ -139245,6 +146220,7 @@ + @@ -139285,6 +146261,11 @@ + + + + + @@ -139324,6 +146305,7 @@ + @@ -139361,6 +146343,7 @@ + @@ -139474,6 +146457,7 @@ + @@ -139508,6 +146492,7 @@ + @@ -139547,6 +146532,7 @@ + @@ -139579,6 +146565,7 @@ + @@ -139611,6 +146598,11 @@ + + + + + @@ -139650,6 +146642,7 @@ + @@ -139688,6 +146681,7 @@ + @@ -139776,6 +146770,7 @@ + @@ -139859,6 +146854,7 @@ + @@ -139898,6 +146894,7 @@ + @@ -139932,6 +146929,7 @@ + @@ -139972,6 +146970,7 @@ + @@ -140009,6 +147008,7 @@ + @@ -140043,6 +147043,7 @@ + @@ -140068,6 +147069,7 @@

Confidence Level: 2

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -140075,7 +147077,8 @@ - + + @@ -140118,6 +147121,7 @@ + @@ -140150,6 +147154,7 @@ + @@ -140184,6 +147189,7 @@ + @@ -140223,6 +147229,7 @@ + @@ -140300,6 +147307,7 @@ + @@ -140341,6 +147349,7 @@ + @@ -140421,6 +147430,7 @@ + @@ -140460,6 +147470,7 @@ + @@ -140508,6 +147519,7 @@ + @@ -140547,6 +147559,7 @@ + @@ -140669,6 +147682,7 @@ + @@ -140754,6 +147768,7 @@ + @@ -140877,6 +147892,11 @@ + + + + + @@ -140917,6 +147937,11 @@ + + + + + @@ -150328,6 +157353,11 @@ + + + + + @@ -150373,6 +157403,11 @@ + + + + + @@ -150394,6 +157429,11 @@ + + + + + @@ -150415,6 +157455,11 @@ + + + + + @@ -150436,6 +157481,11 @@ + + + + + @@ -150457,6 +157507,11 @@ + + + + + @@ -150478,6 +157533,11 @@ + + + + + @@ -150500,6 +157560,11 @@ + + + + + @@ -150522,6 +157587,11 @@ + + + + + @@ -150543,6 +157613,11 @@ + + + + + @@ -150564,6 +157639,11 @@ + + + + + @@ -150643,6 +157723,11 @@ + + + + + @@ -150664,6 +157749,11 @@ + + + + + @@ -150685,6 +157775,11 @@ + + + + + @@ -150706,6 +157801,11 @@ + + + + + @@ -150729,6 +157829,7 @@ + @@ -150758,6 +157859,7 @@ + @@ -150785,6 +157887,11 @@ + + + + + @@ -150806,6 +157913,11 @@ + + + + + @@ -150830,6 +157942,11 @@ + + + + + @@ -150859,6 +157976,7 @@ + @@ -150888,6 +158006,7 @@ + @@ -150915,6 +158034,11 @@ + + + + + @@ -150938,6 +158062,7 @@ + @@ -150967,6 +158092,7 @@ + @@ -150994,6 +158120,11 @@ + + + + + @@ -151015,6 +158146,11 @@ + + + + + @@ -151038,6 +158174,7 @@ + @@ -151067,6 +158204,7 @@ + @@ -151096,6 +158234,7 @@ + @@ -151124,6 +158263,11 @@ + + + + + @@ -151203,6 +158347,11 @@ + + + + + @@ -151226,6 +158375,7 @@ + @@ -151255,6 +158405,7 @@ + @@ -151284,6 +158435,7 @@ + @@ -151313,6 +158465,7 @@ + @@ -151342,6 +158495,7 @@ + @@ -151369,6 +158523,11 @@ + + + + + @@ -151385,6 +158544,7 @@

Confidence Level: 0

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -151392,7 +158552,8 @@ - + + @@ -151414,6 +158575,7 @@

Confidence Level: 0

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -151421,7 +158583,8 @@ - + + @@ -151450,6 +158613,7 @@ + @@ -151472,6 +158636,7 @@

Confidence Level: 2

+

NOTES: model.S(601,2491) curated (PR #222)

 @@ -151479,6 +158644,7 @@ + @@ -151492,11 +158658,11 @@ - + @@ -151512,6 +158678,11 @@ + + + + + @@ -151535,6 +158706,7 @@ + @@ -151564,6 +158736,7 @@ + @@ -151593,6 +158766,7 @@ + @@ -151622,6 +158796,7 @@ + @@ -151651,6 +158826,7 @@ + @@ -151680,6 +158856,7 @@ + @@ -151709,6 +158886,7 @@ + @@ -151738,6 +158916,8 @@ + + @@ -151769,6 +158949,8 @@ + + @@ -151800,6 +158982,8 @@ + + @@ -151831,6 +159015,8 @@ + + @@ -151862,6 +159048,8 @@ + + @@ -151893,6 +159081,8 @@ + + @@ -151924,6 +159114,8 @@ + + @@ -151953,6 +159145,11 @@ + + + + + @@ -151976,6 +159173,7 @@ + @@ -152005,6 +159203,8 @@ + + @@ -152040,6 +159240,7 @@ + @@ -152075,6 +159276,11 @@ + + + + + @@ -152096,6 +159302,11 @@ + + + + + @@ -152141,6 +159352,11 @@ + + + + + @@ -152162,6 +159378,11 @@ + + + + + @@ -152183,6 +159404,11 @@ + + + + + @@ -152206,6 +159432,7 @@ + @@ -152235,6 +159462,7 @@ + @@ -152263,6 +159491,11 @@ + + + + + @@ -152315,6 +159548,7 @@ + @@ -152344,6 +159578,7 @@ + @@ -152372,6 +159607,11 @@ + + + + + @@ -152395,6 +159635,7 @@ + @@ -152422,6 +159663,11 @@ + + + + + @@ -152445,6 +159691,7 @@ + @@ -152476,6 +159723,11 @@ + + + + + @@ -152557,6 +159809,7 @@ + @@ -152584,6 +159837,11 @@ + + + + + @@ -152606,6 +159864,11 @@ + + + + + @@ -152628,6 +159891,11 @@ + + + + + @@ -152650,6 +159918,11 @@ + + + + + @@ -152673,6 +159946,7 @@ + @@ -152705,6 +159979,7 @@ + @@ -152731,6 +160006,7 @@ + @@ -152760,6 +160036,7 @@ + @@ -152792,6 +160069,7 @@ + @@ -152823,6 +160101,7 @@ + @@ -152881,6 +160160,7 @@ + @@ -152907,6 +160187,8 @@ + + @@ -152938,6 +160220,8 @@ + + @@ -152969,6 +160253,8 @@ + + @@ -153003,6 +160289,8 @@ + + @@ -153034,6 +160322,7 @@ + @@ -153061,6 +160350,11 @@ + + + + + @@ -153082,6 +160376,11 @@ + + + + + @@ -153105,6 +160404,7 @@ + @@ -153134,6 +160434,7 @@ + @@ -153165,6 +160466,7 @@ + @@ -153358,6 +160660,7 @@ + @@ -153390,6 +160693,11 @@ + + + + + @@ -153448,6 +160756,8 @@ + + @@ -153506,6 +160816,11 @@ + + + + + @@ -153529,6 +160844,7 @@ + @@ -153560,6 +160876,7 @@ + @@ -153591,6 +160908,7 @@ + @@ -153622,6 +160940,7 @@ + @@ -153651,6 +160970,7 @@ + @@ -153680,6 +161000,7 @@ + @@ -153709,6 +161030,7 @@ + @@ -153738,6 +161060,7 @@ + @@ -153767,6 +161090,7 @@ + @@ -153796,6 +161120,7 @@ + @@ -153825,6 +161150,7 @@ + @@ -153853,6 +161179,11 @@ + + + + + @@ -153876,6 +161207,8 @@ + + @@ -153907,6 +161240,8 @@ + + @@ -153937,6 +161272,11 @@ + + + + + @@ -153959,6 +161299,11 @@ + + + + + @@ -153980,6 +161325,11 @@ + + + + + @@ -154012,6 +161362,7 @@ + @@ -154040,6 +161391,11 @@ + + + + + @@ -154064,6 +161420,8 @@ + + @@ -154088,6 +161446,11 @@ + + + + + @@ -154110,6 +161473,11 @@ + + + + + @@ -154131,6 +161499,11 @@ + + + + + @@ -154150,7 +161523,7 @@

Confidence Level: NaN

-

NOTES: added after the Biolog update (PR #149); D-glucose exchange

+

NOTES: added after the Biolog update (PR #149); D-glucose exchange | MetaNetX ID curated (PR #220)

 @@ -154158,7 +161531,8 @@ - + + @@ -154183,6 +161557,11 @@ + + + + + @@ -154205,6 +161584,11 @@ + + + + + @@ -154228,6 +161612,7 @@ + @@ -154264,6 +161649,11 @@ + + + + + @@ -154285,6 +161675,11 @@ + + + + + @@ -154314,6 +161709,7 @@ + @@ -154343,6 +161739,7 @@ + @@ -154372,6 +161769,8 @@ + + @@ -154404,6 +161803,7 @@ + @@ -154436,6 +161836,7 @@ + @@ -154495,6 +161896,7 @@ + @@ -154523,6 +161925,11 @@ + + + + + @@ -154546,6 +161953,7 @@ + @@ -154575,6 +161983,8 @@ + + @@ -154607,6 +162017,11 @@ + + + + + @@ -154630,6 +162045,7 @@ + @@ -154659,6 +162075,7 @@ + @@ -154688,6 +162105,7 @@ + @@ -154717,6 +162135,8 @@ + + @@ -154749,6 +162169,7 @@ + @@ -154781,6 +162202,8 @@ + + @@ -154813,6 +162236,7 @@ + @@ -154840,6 +162264,11 @@ + + + + + @@ -154866,6 +162295,7 @@ + @@ -154901,6 +162331,7 @@ + @@ -154930,6 +162361,8 @@ + + @@ -154955,6 +162388,7 @@

Confidence Level: 0

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -154962,7 +162396,8 @@ - + + @@ -154996,6 +162431,7 @@ + @@ -155025,6 +162461,7 @@ + @@ -155052,6 +162489,11 @@ + + + + + @@ -155076,6 +162518,11 @@ + + + + + @@ -155099,6 +162546,7 @@ + @@ -155128,6 +162576,7 @@ + @@ -155157,6 +162606,7 @@ + @@ -155184,6 +162634,11 @@ + + + + + @@ -155207,6 +162662,7 @@ + @@ -155234,6 +162690,11 @@ + + + + + @@ -155257,6 +162718,7 @@ + @@ -155304,41 +162766,6 @@ - - - -

Confidence Level: 2

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -155349,6 +162776,11 @@ + + + + + @@ -155372,6 +162804,7 @@ + @@ -155401,6 +162834,7 @@ + @@ -155428,6 +162862,11 @@ + + + + + @@ -155472,6 +162911,7 @@ + @@ -155501,6 +162941,7 @@ + @@ -155530,6 +162971,7 @@ + @@ -155565,6 +163007,7 @@ + @@ -155600,6 +163043,7 @@ + @@ -155633,6 +163077,11 @@ + + + + + @@ -155659,6 +163108,7 @@ + @@ -155688,6 +163138,7 @@ + @@ -155715,6 +163166,11 @@ + + + + + @@ -155738,6 +163194,8 @@ + + @@ -155771,6 +163229,11 @@ + + + + + @@ -155792,6 +163255,11 @@ + + + + + @@ -155814,6 +163282,11 @@ + + + + + @@ -155837,6 +163310,7 @@ + @@ -155866,6 +163340,7 @@ + @@ -155898,6 +163373,7 @@ + @@ -155925,6 +163401,11 @@ + + + + + @@ -155953,6 +163434,11 @@ + + + + + @@ -155975,6 +163461,11 @@ + + + + + @@ -155998,6 +163489,7 @@ + @@ -156027,6 +163519,7 @@ + @@ -156088,6 +163581,7 @@ + @@ -156121,6 +163615,11 @@ + + + + + @@ -156143,6 +163642,11 @@ + + + + + @@ -156165,6 +163669,11 @@ + + + + + @@ -156193,6 +163702,7 @@ + @@ -156215,7 +163725,7 @@

Confidence Level: NaN

-

NOTES: added after the Biolog update (PR #149); L-glycine exchange

+

NOTES: added after the Biolog update (PR #149); L-glycine exchange | MetaNetX ID curated (PR #220)

 @@ -156223,7 +163733,7 @@ - + @@ -156249,6 +163759,7 @@ + @@ -156281,6 +163792,7 @@ + @@ -156310,6 +163822,7 @@ + @@ -156337,6 +163850,11 @@ + + + + + @@ -156359,6 +163877,11 @@ + + + + + @@ -156382,6 +163905,7 @@ + @@ -156414,6 +163938,7 @@ + @@ -156442,6 +163967,11 @@ + + + + + @@ -156465,6 +163995,7 @@ + @@ -156493,6 +164024,11 @@ + + + + + @@ -156516,6 +164052,8 @@ + + @@ -156548,6 +164086,7 @@ + @@ -156577,6 +164116,7 @@ + @@ -156606,6 +164146,7 @@ + @@ -156635,6 +164176,7 @@ + @@ -156664,6 +164206,7 @@ + @@ -156722,6 +164265,7 @@ + @@ -156751,6 +164295,7 @@ + @@ -156807,6 +164352,11 @@ + + + + + @@ -156880,6 +164430,7 @@ + @@ -156907,6 +164458,11 @@ + + + + + @@ -156965,6 +164521,7 @@ + @@ -156994,6 +164551,7 @@ + @@ -157021,6 +164579,11 @@ + + + + + @@ -157044,6 +164607,7 @@ + @@ -157071,6 +164635,11 @@ + + + + + @@ -157094,6 +164663,7 @@ + @@ -157123,6 +164693,7 @@ + @@ -157152,6 +164723,7 @@ + @@ -157180,6 +164752,11 @@ + + + + + @@ -157203,6 +164780,7 @@ + @@ -157232,6 +164810,7 @@ + @@ -157261,6 +164840,8 @@ + + @@ -157531,6 +165112,11 @@ + + + + + @@ -157552,6 +165138,11 @@ + + + + + @@ -157575,6 +165166,7 @@ + @@ -157604,6 +165196,7 @@ + @@ -157631,6 +165224,11 @@ + + + + + @@ -157652,6 +165250,11 @@ + + + + + @@ -157673,6 +165276,11 @@ + + + + + @@ -157696,6 +165304,7 @@ + @@ -157725,6 +165334,7 @@ + @@ -157752,6 +165362,11 @@ + + + + + @@ -157773,6 +165388,11 @@ + + + + + @@ -157801,6 +165421,8 @@ + + @@ -157831,6 +165453,11 @@ + + + + + @@ -157854,6 +165481,7 @@ + @@ -157882,6 +165510,11 @@ + + + + + @@ -157905,6 +165538,7 @@ + @@ -157934,6 +165568,7 @@ + @@ -157968,6 +165603,11 @@ + + + + + @@ -157990,6 +165630,11 @@ + + + + + @@ -158012,6 +165657,11 @@ + + + + + @@ -158034,6 +165684,11 @@ + + + + + @@ -158057,6 +165712,7 @@ + @@ -158088,6 +165744,11 @@ + + + + + @@ -158111,6 +165772,7 @@ + @@ -158140,6 +165802,7 @@ + @@ -158167,6 +165830,11 @@ + + + + + @@ -158190,6 +165858,8 @@ + + @@ -158220,6 +165890,11 @@ + + + + + @@ -158271,6 +165946,11 @@ + + + + + @@ -158321,6 +166001,11 @@ + + + + + @@ -158344,6 +166029,7 @@ + @@ -158372,6 +166058,11 @@ + + + + + @@ -158394,6 +166085,11 @@ + + + + + @@ -158417,6 +166113,7 @@ + @@ -158445,6 +166142,11 @@ + + + + + @@ -158466,6 +166168,11 @@ + + + + + @@ -158489,6 +166196,7 @@ + @@ -158517,6 +166225,11 @@ + + + + + @@ -158539,6 +166252,11 @@ + + + + + @@ -158561,6 +166279,11 @@ + + + + + @@ -158584,6 +166307,7 @@ + @@ -158612,6 +166336,11 @@ + + + + + @@ -158667,6 +166396,7 @@ + @@ -158702,6 +166432,11 @@ + + + + + @@ -158725,6 +166460,7 @@ + @@ -158772,6 +166508,11 @@ + + + + + @@ -158794,6 +166535,11 @@ + + + + + @@ -158816,6 +166562,11 @@ + + + + + @@ -158838,6 +166589,11 @@ + + + + + @@ -158859,6 +166615,11 @@ + + + + + @@ -158880,6 +166641,11 @@ + + + + + @@ -159175,6 +166941,7 @@ + @@ -159207,6 +166974,7 @@ + @@ -159233,6 +167001,7 @@ + @@ -159262,6 +167031,7 @@ + @@ -159294,6 +167064,8 @@ + + @@ -159562,6 +167334,11 @@ + + + + + @@ -159606,6 +167383,7 @@ + @@ -159635,6 +167413,7 @@ + @@ -159664,6 +167443,7 @@ + @@ -159720,6 +167500,11 @@ + + + + + @@ -159741,6 +167526,11 @@ + + + + + @@ -159764,6 +167554,7 @@ + @@ -159822,6 +167613,7 @@ + @@ -159851,6 +167643,7 @@ + @@ -159883,6 +167676,7 @@ + @@ -159915,6 +167709,7 @@ + @@ -159947,6 +167742,7 @@ + @@ -159976,6 +167772,7 @@ + @@ -160005,6 +167802,7 @@ + @@ -160034,6 +167832,7 @@ + @@ -160063,6 +167862,7 @@ + @@ -160090,6 +167890,11 @@ + + + + + @@ -160112,6 +167917,11 @@ + + + + + @@ -160135,6 +167945,7 @@ + @@ -160157,6 +167968,7 @@

Confidence Level: NaN

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -160164,7 +167976,9 @@ - + + + @@ -160190,6 +168004,7 @@ + @@ -160222,6 +168037,7 @@ + @@ -160249,6 +168065,11 @@ + + + + + @@ -160270,6 +168091,11 @@ + + + + + @@ -160291,6 +168117,11 @@ + + + + + @@ -160314,6 +168145,7 @@ + @@ -160343,6 +168175,7 @@ + @@ -160372,6 +168205,8 @@ + + @@ -160404,6 +168239,7 @@ + @@ -160431,6 +168267,11 @@ + + + + + @@ -160452,6 +168293,11 @@ + + + + + @@ -160473,6 +168319,11 @@ + + + + + @@ -160496,6 +168347,7 @@ + @@ -160525,6 +168377,7 @@ + @@ -160582,6 +168435,11 @@ + + + + + @@ -160635,6 +168493,11 @@ + + + + + @@ -160658,6 +168521,7 @@ + @@ -160687,6 +168551,7 @@ + @@ -160714,6 +168579,11 @@ + + + + + @@ -160737,6 +168607,8 @@ + + @@ -160772,6 +168644,8 @@ + + @@ -160804,6 +168678,8 @@ + + @@ -160833,6 +168709,11 @@ + + + + + @@ -160856,6 +168737,8 @@ + + @@ -160887,6 +168770,8 @@ + + @@ -160918,6 +168803,7 @@ + @@ -160946,6 +168832,11 @@ + + + + + @@ -160969,6 +168860,7 @@ + @@ -160996,6 +168888,11 @@ + + + + + @@ -161020,6 +168917,11 @@ + + + + + @@ -161043,6 +168945,7 @@ + @@ -161072,6 +168975,7 @@ + @@ -161104,6 +169008,7 @@ + @@ -161139,6 +169044,7 @@ + @@ -161166,6 +169072,11 @@ + + + + + @@ -161187,6 +169098,11 @@ + + + + + @@ -161210,6 +169126,7 @@ + @@ -161240,6 +169157,11 @@ + + + + + @@ -161261,6 +169183,11 @@ + + + + + @@ -161284,6 +169211,7 @@ + @@ -161314,6 +169242,11 @@ + + + + + @@ -161335,6 +169268,11 @@ + + + + + @@ -161358,6 +169296,7 @@ + @@ -161387,6 +169326,7 @@ + @@ -161414,6 +169354,11 @@ + + + + + @@ -161436,6 +169381,11 @@ + + + + + @@ -161459,6 +169409,7 @@ + @@ -161487,6 +169438,11 @@ + + + + + @@ -161509,6 +169465,11 @@ + + + + + @@ -161532,6 +169493,7 @@ + @@ -161556,6 +169518,11 @@ + + + + + @@ -161608,6 +169575,8 @@ + + @@ -161642,6 +169611,8 @@ + + @@ -161672,6 +169643,11 @@ + + + + + @@ -161693,6 +169669,11 @@ + + + + + @@ -161714,6 +169695,11 @@ + + + + + @@ -161737,6 +169723,8 @@ + + @@ -161768,6 +169756,7 @@ + @@ -161807,6 +169796,7 @@ + @@ -161846,6 +169836,7 @@ + @@ -161876,6 +169867,11 @@ + + + + + @@ -161899,6 +169895,8 @@ + + @@ -161931,6 +169929,7 @@ + @@ -162016,6 +170015,11 @@ + + + + + @@ -162039,6 +170043,7 @@ + @@ -162068,6 +170073,7 @@ + @@ -162097,6 +170103,7 @@ + @@ -162155,6 +170162,7 @@ + @@ -162182,6 +170190,11 @@ + + + + + @@ -162204,6 +170217,11 @@ + + + + + @@ -162225,6 +170243,11 @@ + + + + + @@ -162248,6 +170271,7 @@ + @@ -162277,6 +170301,7 @@ + @@ -162312,6 +170337,7 @@ + @@ -162341,6 +170367,7 @@ + @@ -162370,6 +170397,7 @@ + @@ -162399,6 +170427,7 @@ + @@ -162428,6 +170457,7 @@ + @@ -162455,6 +170485,11 @@ + + + + + @@ -162478,6 +170513,7 @@ + @@ -162505,6 +170541,11 @@ + + + + + @@ -162528,6 +170569,7 @@ + @@ -162556,6 +170598,11 @@ + + + + + @@ -162579,6 +170626,7 @@ + @@ -162612,6 +170660,11 @@ + + + + + @@ -162720,6 +170773,7 @@

Confidence Level: 0

+

NOTES: MetaNetX ID curated (PR #220)

 @@ -162733,7 +170787,7 @@ - + @@ -162767,6 +170821,7 @@ + @@ -162896,6 +170951,7 @@ + @@ -162925,6 +170981,7 @@ + @@ -162954,6 +171011,7 @@ + @@ -162981,6 +171039,11 @@ + + + + + @@ -163002,6 +171065,11 @@ + + + + + @@ -163023,6 +171091,11 @@ + + + + + @@ -163044,6 +171117,11 @@ + + + + + @@ -163073,6 +171151,7 @@ + @@ -163105,6 +171184,7 @@ + @@ -163132,6 +171212,11 @@ + + + + + @@ -163179,6 +171264,7 @@ + @@ -163444,6 +171530,7 @@

Confidence Level: 0

+

NOTES: model.S(1640,2934) curated (PR #222)

 @@ -163459,6 +171546,7 @@ + @@ -163470,6 +171558,7 @@

Confidence Level: 0

+

NOTES: model.S(1640,2935) curated (PR #222)

 @@ -163485,6 +171574,7 @@ + @@ -163496,6 +171586,7 @@

Confidence Level: 0

+

NOTES: model.S(1640,2936) curated (PR #222)

 @@ -163511,6 +171602,7 @@ + @@ -163522,6 +171614,7 @@

Confidence Level: 0

+

NOTES: model.S(1640,2937) curated (PR #222)

 @@ -163537,6 +171630,7 @@ + @@ -163548,6 +171642,7 @@

Confidence Level: 0

+

NOTES: model.S(1640,2938) curated (PR #222)

 @@ -163563,6 +171658,7 @@ + @@ -163574,6 +171670,7 @@

Confidence Level: 0

+

NOTES: model.S(1640,2939) curated (PR #222)

 @@ -163589,6 +171686,7 @@ + @@ -163600,6 +171698,7 @@

Confidence Level: 0

+

NOTES: model.S(1640,2940) curated (PR #222)

 @@ -163615,6 +171714,7 @@ + @@ -163626,6 +171726,7 @@

Confidence Level: 0

+

NOTES: model.S(1640,2941) curated (PR #222)

 @@ -163641,6 +171742,7 @@ + @@ -163652,6 +171754,7 @@

Confidence Level: 0

+

NOTES: model.S(1658,2942) curated (PR #222)

 @@ -163667,6 +171770,7 @@ + @@ -163678,6 +171782,7 @@

Confidence Level: 0

+

NOTES: model.S(1658,2943) curated (PR #222)

 @@ -163693,6 +171798,7 @@ + @@ -163704,6 +171810,7 @@

Confidence Level: 0

+

NOTES: model.S(1658,2944) curated (PR #222)

 @@ -163719,6 +171826,7 @@ + @@ -163730,6 +171838,7 @@

Confidence Level: 0

+

NOTES: model.S(1658,2945) curated (PR #222)

 @@ -163745,6 +171854,7 @@ + @@ -163756,6 +171866,7 @@

Confidence Level: 0

+

NOTES: model.S(1658,2946) curated (PR #222)

 @@ -163771,6 +171882,7 @@ + @@ -163782,6 +171894,7 @@

Confidence Level: 0

+

NOTES: model.S(1658,2947) curated (PR #222)

 @@ -163797,6 +171910,7 @@ + @@ -163808,6 +171922,7 @@

Confidence Level: 0

+

NOTES: model.S(1658,2948) curated (PR #222)

 @@ -163823,6 +171938,7 @@ + @@ -163834,6 +171950,7 @@

Confidence Level: 0

+

NOTES: model.S(1658,2949) curated (PR #222)

 @@ -163849,6 +171966,7 @@ + @@ -175653,6 +183771,11 @@ + + + + + @@ -175674,6 +183797,11 @@ + + + + + @@ -175730,6 +183858,11 @@ + + + + + @@ -178612,7 +186745,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -178620,10 +186753,11 @@ + - + @@ -178660,6 +186794,7 @@ + @@ -178728,7 +186863,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(606,3523) curated (PR #222)

 @@ -178755,7 +186890,7 @@ - + @@ -179310,6 +187445,7 @@ + @@ -179350,6 +187486,7 @@ + @@ -179539,6 +187676,7 @@ + @@ -179627,6 +187765,7 @@ + @@ -179670,6 +187809,7 @@ + @@ -179753,6 +187893,7 @@ + @@ -179830,6 +187971,7 @@ + @@ -179860,7 +188002,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | alternative MetaNetX ID MNXR139547 (PR #220) | model.S(601,3553) curated (PR #222)

 @@ -179887,6 +188029,7 @@ + @@ -179945,6 +188088,7 @@ + @@ -179972,7 +188116,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -179982,7 +188126,7 @@ - + @@ -180016,6 +188160,7 @@ + @@ -180053,6 +188198,7 @@ + @@ -180273,6 +188419,7 @@ + @@ -180343,7 +188490,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -180353,7 +188500,7 @@ - + @@ -180380,7 +188527,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -180390,7 +188537,7 @@ - + @@ -180420,7 +188567,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -180430,7 +188577,7 @@ - + @@ -180457,7 +188604,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(601,3569) curated (PR #222)

 @@ -180465,6 +188612,7 @@ + @@ -180484,6 +188632,7 @@ + @@ -180565,7 +188714,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -180573,9 +188722,10 @@ + - + @@ -180641,7 +188791,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -180651,7 +188801,7 @@ - + @@ -180678,7 +188828,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -180686,10 +188836,11 @@ + - + @@ -180716,7 +188867,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -180727,7 +188878,7 @@ - + @@ -180793,7 +188944,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -180804,7 +188955,7 @@ - + @@ -180846,6 +188997,7 @@ + @@ -180891,6 +189043,7 @@ + @@ -180965,6 +189118,7 @@ + @@ -181032,7 +189186,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(601,3584) curated (PR #222)

 @@ -181057,6 +189211,7 @@ + @@ -181151,6 +189306,7 @@ + @@ -181189,6 +189345,7 @@ + @@ -181264,6 +189421,7 @@ + @@ -181347,6 +189505,7 @@ + @@ -181384,6 +189543,7 @@ + @@ -181421,6 +189581,7 @@ + @@ -181495,6 +189656,7 @@ + @@ -181567,6 +189729,7 @@ + @@ -181675,43 +189838,6 @@ - - - -

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -181724,6 +189850,7 @@ + @@ -182063,7 +190190,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | KEGG ID curated (PR #220)

 @@ -182182,6 +190309,7 @@ + @@ -182218,6 +190346,7 @@ + @@ -182247,7 +190376,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(602,3615) curated (PR #222)

 @@ -182269,6 +190398,7 @@ + @@ -182284,7 +190414,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(606,3616) curated (PR #222)

 @@ -182307,11 +190437,11 @@ + - @@ -182322,7 +190452,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220)

 @@ -182331,7 +190461,7 @@ - + @@ -182360,7 +190490,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(602,3618) curated (PR #222)

 @@ -182382,23 +190512,23 @@ + - - +

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220)

 @@ -182406,9 +190536,10 @@ + - - + + @@ -182433,7 +190564,7 @@ - +

Confidence Level: 2

@@ -182445,6 +190576,7 @@ + @@ -182633,6 +190765,7 @@ + @@ -182772,6 +190905,7 @@ + @@ -182808,6 +190942,7 @@ + @@ -182846,6 +190981,7 @@ + @@ -182920,6 +191056,7 @@ + @@ -183080,6 +191217,7 @@ + @@ -183278,7 +191416,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(608,3642) curated (PR #222)

 @@ -183300,12 +191438,12 @@ - + @@ -183398,6 +191536,7 @@ + @@ -183475,6 +191614,7 @@ + @@ -183513,6 +191653,7 @@ + @@ -183551,6 +191692,7 @@ + @@ -183589,6 +191731,7 @@ + @@ -183627,6 +191770,7 @@ + @@ -183662,6 +191806,7 @@ + @@ -183701,6 +191846,7 @@ + @@ -183740,6 +191886,7 @@ + @@ -183779,6 +191926,7 @@ + @@ -183857,6 +192005,7 @@ + @@ -183888,7 +192037,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(601,3658) curated (PR #222)

 @@ -183915,7 +192064,7 @@ - + @@ -183966,7 +192115,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(601,3660) curated (PR #222)

 @@ -183993,7 +192142,7 @@ - + @@ -184013,6 +192162,7 @@ + @@ -184044,7 +192194,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(601,3662) curated (PR #222)

 @@ -184071,7 +192221,7 @@ - + @@ -184091,6 +192241,7 @@ + @@ -184122,7 +192273,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(942,3664) curated (PR #222) | model.S(947,3664) curated (PR #222)

 @@ -184145,10 +192296,12 @@ + + @@ -184159,7 +192312,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(942,3665) curated (PR #222) | model.S(947,3665) curated (PR #222)

 @@ -184182,10 +192335,12 @@ + + @@ -184196,7 +192351,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(601,3666) curated (PR #222)

 @@ -184223,7 +192378,7 @@ - + @@ -184235,7 +192390,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(601,3667) curated (PR #222)

 @@ -184262,7 +192417,7 @@ - + @@ -184274,7 +192429,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(601,3668) curated (PR #222)

 @@ -184301,7 +192456,7 @@ - + @@ -184501,7 +192656,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(602,3674) curated (PR #222)

 @@ -184529,7 +192684,6 @@ - @@ -184586,6 +192740,7 @@ + @@ -184661,6 +192816,7 @@ + @@ -184763,7 +192919,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(602,3681) curated (PR #222)

 @@ -184785,12 +192941,12 @@ + - @@ -184801,7 +192957,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | model.S(602,3682) curated (PR #222)

 @@ -184823,12 +192979,12 @@ + - @@ -184987,7 +193143,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220) | model.S(606,3687) curated (PR #222)

 @@ -184995,10 +193151,11 @@ + - + @@ -185014,7 +193171,7 @@ - + @@ -185061,7 +193218,7 @@

Confidence Level: 2

-

NOTES: added after new annotation (PR #142)

+

NOTES: added after new annotation (PR #142) | MetaNetX ID curated (PR #220) | model.S(602,3689) curated (PR #222)

 @@ -185071,7 +193228,7 @@ - + @@ -185087,6 +193244,7 @@ + @@ -185104,6 +193262,11 @@ + + + + + @@ -185134,6 +193297,7 @@ + @@ -185209,6 +193373,11 @@ + + + + + @@ -185319,6 +193488,7 @@ + @@ -185357,6 +193527,7 @@ + @@ -185520,7 +193691,7 @@

Confidence Level: 1

-

NOTES: added after the Biolog update (PR #149); bigg:EX_glyc2p_e;glycerol 2-phosphate(2-)_P Source

+

NOTES: added after the Biolog update (PR #149); bigg:EX_glyc2p_e;glycerol 2-phosphate(2-)_P Source | MetaNetX ID curated (PR #220)

 @@ -185528,7 +193699,7 @@ - + @@ -185558,6 +193729,7 @@ + @@ -185717,6 +193889,7 @@ + @@ -185749,6 +193922,11 @@ + + + + + @@ -185778,6 +193956,7 @@ + @@ -185810,6 +193989,7 @@ + @@ -185972,6 +194152,7 @@ + @@ -186098,6 +194279,7 @@ + @@ -186132,6 +194314,7 @@ + @@ -186321,6 +194504,7 @@ + @@ -186356,6 +194540,7 @@ + @@ -186574,7 +194759,7 @@

Confidence Level: 1

-

NOTES: added after the Biolog update (PR #149); rhea:28278;3-sulfino-L-alanine_S Source

+

NOTES: added after the Biolog update (PR #149); rhea:28278;3-sulfino-L-alanine_S Source | model.S(601,3735) curated (PR #222)

 @@ -186600,6 +194785,7 @@ + @@ -186648,6 +194834,7 @@ + @@ -186745,6 +194932,7 @@ + @@ -186834,7 +195022,7 @@

Confidence Level: 1

-

NOTES: added after the Biolog update (PR #149); R00029;tetrathionate_S Source

+

NOTES: added after the Biolog update (PR #149); R00029;tetrathionate_S Source | MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220) | model.S(2597,3743) curated (PR #222) | model.S(2598,3743) curated (PR #222)

 @@ -186843,7 +195031,8 @@ - + + @@ -186856,11 +195045,11 @@ - + - + @@ -186905,6 +195094,7 @@ + @@ -187101,7 +195291,7 @@

Confidence Level: 1

-

NOTES: added after the Biolog update (PR #149); seed:rxn09978;methyl alpha-D-glucopyranoside_C Source

+

NOTES: added after the Biolog update (PR #149); seed:rxn09978;methyl alpha-D-glucopyranoside_C Source | MetaNetX ID curated (PR #220)

 @@ -187110,7 +195300,7 @@ - + @@ -187142,6 +195332,7 @@ + @@ -187164,7 +195355,7 @@

Confidence Level: 1

-

NOTES: added after the Biolog update (PR #149); seed:rxn12524;methyl alpha-D-glucopyranoside_C Source

+

NOTES: added after the Biolog update (PR #149); seed:rxn12524;methyl alpha-D-glucopyranoside_C Source | MetaNetX ID curated (PR #220)

 @@ -187172,7 +195363,7 @@ - + @@ -187205,6 +195396,7 @@ + @@ -187263,6 +195455,7 @@ + @@ -187312,6 +195505,7 @@ + @@ -187348,6 +195542,7 @@ + @@ -187451,7 +195646,9 @@ + + @@ -187642,6 +195839,7 @@ + @@ -187674,6 +195872,7 @@ + @@ -187804,7 +196003,7 @@

Confidence Level: 1

-

NOTES: added after the Biolog update (PR #149); rhea:13441;L-cysteate_S Source

+

NOTES: added after the Biolog update (PR #149); rhea:13441;L-cysteate_S Source | model.S(601,3772) curated (PR #222)

 @@ -187831,6 +196030,7 @@ + @@ -188499,7 +196699,7 @@

Confidence Level: 1

-

NOTES: added after the Biolog update (PR #149); rhea:29715;2-hydroxyethane-1-sulfonate_S Source

+

NOTES: added after the Biolog update (PR #149); rhea:29715;2-hydroxyethane-1-sulfonate_S Source | model.S(601,3793) curated (PR #222)

 @@ -188507,6 +196707,7 @@ + @@ -188527,7 +196728,7 @@ - + @@ -188801,6 +197002,11 @@ + + + + + @@ -188855,6 +197061,7 @@ + @@ -188887,6 +197094,7 @@ + @@ -189039,6 +197247,7 @@ + @@ -189071,6 +197280,7 @@ + @@ -189125,7 +197335,7 @@

Confidence Level: 1

-

NOTES: added after the Biolog update (PR #149); bigg:EX_g6p_e;D-glucose 6-phosphate_P Source

+

NOTES: added after the Biolog update (PR #149); bigg:EX_g6p_e;D-glucose 6-phosphate_P Source | MetaNetX ID curated (PR #220)

 @@ -189133,7 +197343,7 @@ - + @@ -189193,6 +197403,7 @@ + @@ -189290,6 +197501,7 @@ + @@ -189322,6 +197534,7 @@ + @@ -189386,6 +197599,7 @@ + @@ -189416,6 +197630,7 @@ + @@ -189446,6 +197661,7 @@ + @@ -189540,6 +197756,7 @@ + @@ -189572,6 +197789,7 @@ + @@ -189600,6 +197818,11 @@ + + + + + @@ -189633,6 +197856,7 @@ + @@ -189668,6 +197892,7 @@ + @@ -189826,6 +198051,11 @@ + + + + + @@ -189851,6 +198081,11 @@ + + + + + @@ -189878,6 +198113,7 @@ + @@ -190090,6 +198326,7 @@ + @@ -190132,6 +198369,7 @@ + @@ -190166,6 +198404,7 @@ + @@ -190200,6 +198439,7 @@ + @@ -190232,6 +198472,7 @@ + @@ -190259,7 +198500,7 @@

Confidence Level: 1

-

NOTES: added after the Biolog update (PR #149); rhea:16381;D-arabinose_C Source

+

NOTES: added after the Biolog update (PR #149); rhea:16381;D-arabinose_C Source | MetaNetX ID curated (PR #220)

 @@ -190267,9 +198508,10 @@ + - + @@ -190302,6 +198544,7 @@ + @@ -190365,6 +198608,7 @@ + @@ -190425,7 +198669,7 @@

Confidence Level: NaN

-

NOTES: added after the Biolog update (PR #149); bigg:EX_meoh_e;methyl alpha-D-glucopyranoside_C Source

+

NOTES: added after the Biolog update (PR #149); bigg:EX_meoh_e;methyl alpha-D-glucopyranoside_C Source | MetaNetX ID curated (PR #220)

 @@ -190433,7 +198677,8 @@ - + + @@ -190491,6 +198736,11 @@ + + + + + @@ -190535,6 +198785,11 @@ + + + + + @@ -190557,6 +198812,11 @@ + + + + + @@ -190579,6 +198839,11 @@ + + + + + @@ -190623,6 +198888,11 @@ + + + + + @@ -190645,6 +198915,11 @@ + + + + + @@ -190667,6 +198942,11 @@ + + + + + @@ -190689,6 +198969,11 @@ + + + + + @@ -190711,6 +198996,11 @@ + + + + + @@ -190733,6 +199023,11 @@ + + + + + @@ -190755,6 +199050,11 @@ + + + + + @@ -190799,6 +199099,11 @@ + + + + + @@ -190821,6 +199126,11 @@ + + + + + @@ -190843,6 +199153,11 @@ + + + + + @@ -190865,6 +199180,11 @@ + + + + + @@ -190887,6 +199207,11 @@ + + + + + @@ -190909,6 +199234,11 @@ + + + + + @@ -190931,6 +199261,11 @@ + + + + + @@ -190953,6 +199288,11 @@ + + + + + @@ -190975,6 +199315,11 @@ + + + + + @@ -190997,6 +199342,11 @@ + + + + + @@ -191019,6 +199369,11 @@ + + + + + @@ -191041,6 +199396,11 @@ + + + + + @@ -191085,6 +199445,11 @@ + + + + + @@ -191107,6 +199472,11 @@ + + + + + @@ -191129,6 +199499,11 @@ + + + + + @@ -191151,6 +199526,11 @@ + + + + + @@ -191173,6 +199553,11 @@ + + + + + @@ -191217,6 +199602,11 @@ + + + + + @@ -191239,6 +199629,11 @@ + + + + + @@ -191283,6 +199678,11 @@ + + + + + @@ -191349,6 +199749,11 @@ + + + + + @@ -191371,6 +199776,11 @@ + + + + + @@ -191393,6 +199803,11 @@ + + + + + @@ -191415,6 +199830,11 @@ + + + + + @@ -191437,6 +199857,11 @@ + + + + + @@ -191459,6 +199884,11 @@ + + + + + @@ -191481,6 +199911,11 @@ + + + + + @@ -191503,6 +199938,11 @@ + + + + + @@ -191525,6 +199965,11 @@ + + + + + @@ -191569,6 +200014,11 @@ + + + + + @@ -191591,6 +200041,11 @@ + + + + + @@ -191613,6 +200068,11 @@ + + + + + @@ -191635,6 +200095,11 @@ + + + + + @@ -191657,6 +200122,11 @@ + + + + + @@ -191679,6 +200149,11 @@ + + + + + @@ -191723,6 +200198,11 @@ + + + + + @@ -191745,6 +200225,11 @@ + + + + + @@ -191767,6 +200252,11 @@ + + + + + @@ -191789,6 +200279,11 @@ + + + + + @@ -191811,6 +200306,11 @@ + + + + + @@ -191833,6 +200333,11 @@ + + + + + @@ -191855,6 +200360,11 @@ + + + + + @@ -191965,6 +200475,11 @@ + + + + + @@ -191987,6 +200502,11 @@ + + + + + @@ -192009,6 +200529,11 @@ + + + + + @@ -192060,7 +200585,7 @@

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156)

+

NOTES: metabolites observed in metabolomics data (PR #156) | model.S(610,3928) curated (PR #222)

 @@ -192084,6 +200609,7 @@ + @@ -192094,7 +200620,7 @@

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156)

+

NOTES: metabolites observed in metabolomics data (PR #156) | MetaNetX ID curated (PR #220)

 @@ -192103,7 +200629,7 @@ - + @@ -192136,6 +200662,7 @@ + @@ -192196,7 +200723,7 @@

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156)

+

NOTES: metabolites observed in metabolomics data (PR #156) | model.S(400,3932) curated (PR #222) | model.S(601,3932) curated (PR #222) | model.S(610,3932) curated (PR #222)

 @@ -192216,11 +200743,13 @@ + + - + @@ -192271,6 +200800,7 @@ + @@ -192408,7 +200938,7 @@

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156)

+

NOTES: metabolites observed in metabolomics data (PR #156) | MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220)

 @@ -192416,7 +200946,8 @@ - + + @@ -192429,16 +200960,17 @@ + - +

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156)

+

NOTES: metabolites observed in metabolomics data (PR #156) | model.S(2671,3939) curated (PR #222) | model.S(2670,3939) curated (PR #222) | model.S(601,3939) curated (PR #222)

 @@ -192458,13 +200990,13 @@ + - - + @@ -192479,6 +201011,7 @@ + @@ -192513,6 +201046,7 @@ + @@ -192549,6 +201083,7 @@ + @@ -192620,8 +201155,10 @@ + + @@ -192655,6 +201192,7 @@ + @@ -192690,7 +201228,9 @@ + + @@ -192790,6 +201330,7 @@ + @@ -192858,6 +201399,7 @@ + @@ -192893,6 +201435,7 @@ + @@ -192967,6 +201510,11 @@ + + + + + @@ -192989,6 +201537,11 @@ + + + + + @@ -193011,6 +201564,11 @@ + + + + + @@ -193033,6 +201591,11 @@ + + + + + @@ -193055,6 +201618,11 @@ + + + + + @@ -193145,6 +201713,11 @@ + + + + + @@ -193895,1153 +202468,1153 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -196110,7 +204683,6 @@ - @@ -198393,7 +206965,6 @@ - @@ -198951,7 +207522,6 @@ - @@ -199434,7 +208004,6 @@ - diff --git a/ModelFiles/yml/yeastGEM.yml b/ModelFiles/yml/yeastGEM.yml index b0d2d3ee..46ff7f86 100644 --- a/ModelFiles/yml/yeastGEM.yml +++ b/ModelFiles/yml/yeastGEM.yml @@ -7,6 +7,7 @@ - formula: C6H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 13BDglcn - chebi: CHEBI:37671 - kegg.compound: C00965 - metanetx.chemical: MNXM6492 @@ -18,6 +19,7 @@ - formula: C6H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 13BDglcn - chebi: CHEBI:37671 - kegg.compound: C00965 - metanetx.chemical: MNXM6492 @@ -29,6 +31,7 @@ - formula: C6H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 13BDglcn - chebi: CHEBI:37671 - kegg.compound: C00965 - metanetx.chemical: MNXM6492 @@ -40,6 +43,7 @@ - formula: C6H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 16BDglcn - chebi: CHEBI:27380 - kegg.compound: C02493 - metanetx.chemical: MNXM9375 @@ -51,6 +55,7 @@ - formula: C7H8N5O8P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: 2ahhmd - chebi: CHEBI:57602 - kegg.compound: C04807 - metanetx.chemical: MNXM1160 @@ -62,6 +67,7 @@ - formula: C7H6O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: aconm - chebi: CHEBI:57470 - kegg.compound: C11514 - metanetx.chemical: MNXM3742 @@ -73,6 +79,7 @@ - formula: C6H11O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 23dhmp - chebi: CHEBI:49258 - kegg.compound: C06007 - metanetx.chemical: MNXM1202 @@ -84,6 +91,7 @@ - formula: C7H10O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: 3c2hmp - chebi: CHEBI:35121 - kegg.compound: C04411 - metanetx.chemical: MNXM891 @@ -95,6 +103,7 @@ - formula: C7H8O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: 3c4mop - chebi: CHEBI:17214 - kegg.compound: C04236 - metanetx.chemical: MNXM1602 @@ -106,6 +115,7 @@ - formula: C7H8O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: 3c4mop - chebi: CHEBI:17214 - kegg.compound: C04236 - metanetx.chemical: MNXM1602 @@ -117,6 +127,7 @@ - formula: C7H7O7 - charge: -3 - annotation: !!omap + - bigg.metabolite: micit - chebi: CHEBI:57429 - kegg.compound: C04593 - metanetx.chemical: MNXM1694 @@ -125,8 +136,8 @@ - id: s_0013 - name: (5S,6S)-di-HETE - compartment: c - - formula: C20H32O4 - - charge: 0 + - formula: C20H31O4 + - charge: -1 - annotation: !!omap - chebi: CHEBI:53026 - metanetx.chemical: MNXM31306 @@ -135,8 +146,8 @@ - id: s_0014 - name: (5S,6S)-di-HETE - compartment: n - - formula: C20H32O4 - - charge: 0 + - formula: C20H31O4 + - charge: -1 - annotation: !!omap - chebi: CHEBI:53026 - metanetx.chemical: MNXM31306 @@ -148,9 +159,10 @@ - formula: C10H17N4O6 - charge: -1 - annotation: !!omap + - bigg.metabolite: argsuc - chebi: CHEBI:57472 - kegg.compound: C03406 - - metanetx.chemical: MNXM550 + - metanetx.chemical: MNXM722743 - sbo: SBO:0000247 - !!omap - id: s_0016 @@ -159,6 +171,7 @@ - formula: C5H9O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 23dhmb - chebi: CHEBI:49072 - kegg.compound: C04272 - metanetx.chemical: MNXM114097 @@ -167,9 +180,10 @@ - id: s_0017 - name: (R)-4'-phosphopantothenic acid - compartment: c - - formula: C9H18NO8P - - charge: 0 + - formula: C9H15NO8P + - charge: -3 - annotation: !!omap + - bigg.metabolite: 4ppan - chebi: CHEBI:15905 - kegg.compound: C03492 - metanetx.chemical: MNXM415 @@ -181,6 +195,7 @@ - formula: C6H10O10P2 - charge: -4 - annotation: !!omap + - bigg.metabolite: 5dpmev - chebi: CHEBI:57557 - kegg.compound: C01143 - metanetx.chemical: MNXM689 @@ -192,6 +207,7 @@ - formula: C6H10O7P - charge: -3 - annotation: !!omap + - bigg.metabolite: 5pmev - chebi: CHEBI:58146 - kegg.compound: C01107 - metanetx.chemical: MNXM567 @@ -203,6 +219,7 @@ - formula: C4H8O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: actn__R - chebi: CHEBI:15686 - kegg.compound: C00810 - metanetx.chemical: MNXM664 @@ -214,6 +231,7 @@ - formula: C7H15NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: crn - chebi: CHEBI:16347 - kegg.compound: C00318 - metanetx.chemical: MNXM173 @@ -225,6 +243,7 @@ - formula: C7H15NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: crn - chebi: CHEBI:16347 - kegg.compound: C00318 - metanetx.chemical: MNXM173 @@ -236,6 +255,7 @@ - formula: C7H15NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: crn - chebi: CHEBI:16347 - kegg.compound: C00318 - metanetx.chemical: MNXM173 @@ -247,6 +267,7 @@ - formula: C7H15NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: crn - chebi: CHEBI:16347 - kegg.compound: C00318 - metanetx.chemical: MNXM173 @@ -258,6 +279,7 @@ - formula: C3H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: lac__D - chebi: CHEBI:16004 - kegg.compound: C00256 - metanetx.chemical: MNXM285 @@ -269,6 +291,7 @@ - formula: C3H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: lac__D - chebi: CHEBI:16004 - kegg.compound: C00256 - metanetx.chemical: MNXM285 @@ -280,6 +303,7 @@ - formula: C3H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: lac__D - chebi: CHEBI:16004 - kegg.compound: C00256 - metanetx.chemical: MNXM285 @@ -291,6 +315,7 @@ - formula: C6H11O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: mev__R - chebi: CHEBI:36464 - kegg.compound: C00418 - metanetx.chemical: MNXM333 @@ -302,6 +327,7 @@ - formula: C6H11O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: mev__R - chebi: CHEBI:36464 - kegg.compound: C00418 - metanetx.chemical: MNXM333 @@ -313,6 +339,7 @@ - formula: C6H11O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: pant__R - chebi: CHEBI:15980 - kegg.compound: C00522 - metanetx.chemical: MNXM593 @@ -324,6 +351,7 @@ - formula: C9H16NO5 - charge: -1 - annotation: !!omap + - bigg.metabolite: pnto__R - chebi: CHEBI:29032 - kegg.compound: C00864 - metanetx.chemical: MNXM364 @@ -335,6 +363,7 @@ - formula: C9H16NO5 - charge: -1 - annotation: !!omap + - bigg.metabolite: pnto__R - chebi: CHEBI:29032 - kegg.compound: C00864 - metanetx.chemical: MNXM364 @@ -346,6 +375,7 @@ - formula: C13H20N3O8S - charge: -1 - annotation: !!omap + - bigg.metabolite: lgt__S - chebi: CHEBI:57474 - kegg.compound: C03451 - metanetx.chemical: MNXM1253 @@ -357,6 +387,7 @@ - formula: C13H20N3O8S - charge: -1 - annotation: !!omap + - bigg.metabolite: lgt__S - chebi: CHEBI:57474 - kegg.compound: C03451 - metanetx.chemical: MNXM1253 @@ -368,6 +399,7 @@ - formula: C4H10O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: btd_RR - chebi: CHEBI:16982 - kegg.compound: C03044 - metanetx.chemical: MNXM2757 @@ -379,6 +411,7 @@ - formula: C4H10O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: btd_RR - chebi: CHEBI:16982 - kegg.compound: C03044 - metanetx.chemical: MNXM2757 @@ -390,6 +423,7 @@ - formula: C30H50O - charge: 0 - annotation: !!omap + - bigg.metabolite: Ssq23epx - chebi: CHEBI:15441 - kegg.compound: C01054 - metanetx.chemical: MNXM130 @@ -401,6 +435,7 @@ - formula: C30H50O - charge: 0 - annotation: !!omap + - bigg.metabolite: Ssq23epx - chebi: CHEBI:15441 - kegg.compound: C01054 - metanetx.chemical: MNXM130 @@ -412,6 +447,7 @@ - formula: C6H9O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 2ahbut - chebi: CHEBI:49256 - kegg.compound: C06006 - metanetx.chemical: MNXM114220 @@ -420,9 +456,10 @@ - id: s_0042 - name: (R)-3-hydroxydecanoyl-CoA - compartment: p - - formula: C31H54N7O18P3S - - charge: 0 + - formula: C31H50N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3hdcoa - chebi: CHEBI:28325 - kegg.compound: C05264 - metanetx.chemical: MNXM674 @@ -431,8 +468,8 @@ - id: s_0045 - name: (S)-3-hydroxyhexacosanoyl-CoA - compartment: p - - formula: C47H86N7O18P3S - - charge: 0 + - formula: C47H82N7O18P3S + - charge: -4 - annotation: !!omap - chebi: CHEBI:52976 - metanetx.chemical: MNXM31741 @@ -441,9 +478,10 @@ - id: s_0048 - name: (R)-3-hydroxylauroyl-CoA - compartment: p - - formula: C33H58N7O18P3S - - charge: 0 + - formula: C33H54N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3hddcoa - chebi: CHEBI:27668 - kegg.compound: C05262 - metanetx.chemical: MNXM733 @@ -452,9 +490,10 @@ - id: s_0051 - name: (S)-3-hydroxypalmitoyl-CoA - compartment: p - - formula: C37H66N7O18P3S - - charge: 0 + - formula: C37H62N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3hhdcoa - chebi: CHEBI:27402 - kegg.compound: C05258 - metanetx.chemical: MNXM825 @@ -463,9 +502,10 @@ - id: s_0054 - name: (S)-3-hydroxytetradecanoyl-CoA - compartment: p - - formula: C35H62N7O18P3S - - charge: 0 + - formula: C35H58N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3htdcoa - chebi: CHEBI:27466 - kegg.compound: C05260 - metanetx.chemical: MNXM767 @@ -477,6 +517,7 @@ - formula: C6H9O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3mop - chebi: CHEBI:35146 - kegg.compound: C00671 - metanetx.chemical: MNXM439 @@ -488,6 +529,7 @@ - formula: C6H9O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3mop - chebi: CHEBI:35146 - kegg.compound: C00671 - metanetx.chemical: MNXM439 @@ -499,6 +541,7 @@ - formula: C6H9O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3mop - chebi: CHEBI:35146 - kegg.compound: C00671 - metanetx.chemical: MNXM439 @@ -510,6 +553,7 @@ - formula: C5H5N2O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: dhor__S - chebi: CHEBI:30864 - kegg.compound: C00337 - metanetx.chemical: MNXM252 @@ -521,6 +565,7 @@ - formula: C3H6O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: lald__L - chebi: CHEBI:18041 - kegg.compound: C00424 - metanetx.chemical: MNXM2387 @@ -532,6 +577,7 @@ - formula: C3H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: lac__L - chebi: CHEBI:16651 - kegg.compound: C00186 - metanetx.chemical: MNXM179 @@ -543,6 +589,7 @@ - formula: C3H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: lac__L - chebi: CHEBI:16651 - kegg.compound: C00186 - metanetx.chemical: MNXM179 @@ -554,6 +601,7 @@ - formula: C3H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: lac__L - chebi: CHEBI:16651 - kegg.compound: C00186 - metanetx.chemical: MNXM179 @@ -565,6 +613,7 @@ - formula: C4H4O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: mal__L - chebi: CHEBI:15589 - kegg.compound: C00149 - metanetx.chemical: MNXM98 @@ -576,6 +625,7 @@ - formula: C4H4O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: mal__L - chebi: CHEBI:15589 - kegg.compound: C00149 - metanetx.chemical: MNXM98 @@ -587,6 +637,7 @@ - formula: C4H4O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: mal__L - chebi: CHEBI:15589 - kegg.compound: C00149 - metanetx.chemical: MNXM98 @@ -598,6 +649,7 @@ - formula: C4H4O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: mal__L - chebi: CHEBI:15589 - kegg.compound: C00149 - metanetx.chemical: MNXM98 @@ -609,6 +661,7 @@ - formula: C3H4O10P2 - charge: -4 - annotation: !!omap + - bigg.metabolite: 13dpg - chebi: CHEBI:57604 - kegg.compound: C00236 - metanetx.chemical: MNXM261 @@ -620,6 +673,7 @@ - formula: C12H13NO9P - charge: -3 - annotation: !!omap + - bigg.metabolite: 2cpr5p - chebi: CHEBI:58613 - kegg.compound: C01302 - metanetx.chemical: MNXM1455 @@ -631,6 +685,7 @@ - formula: C15H21N5O15P2 - charge: -4 - annotation: !!omap + - bigg.metabolite: prfp - chebi: CHEBI:58435 - kegg.compound: C04896 - metanetx.chemical: MNXM1397 @@ -642,6 +697,7 @@ - formula: C15H19N5O14P2 - charge: -4 - annotation: !!omap + - bigg.metabolite: prbamp - chebi: CHEBI:59457 - kegg.compound: C02741 - metanetx.chemical: MNXM1515 @@ -653,6 +709,7 @@ - formula: C9H18O11P - charge: -1 - annotation: !!omap + - bigg.metabolite: g3pi - chebi: CHEBI:58444 - kegg.compound: C01225 - metanetx.chemical: MNXM1517 @@ -664,6 +721,7 @@ - formula: C9H18O11P - charge: -1 - annotation: !!omap + - bigg.metabolite: g3pi - chebi: CHEBI:58444 - kegg.compound: C01225 - metanetx.chemical: MNXM1517 @@ -675,6 +733,7 @@ - formula: C9H20NO7PR - charge: 1 - annotation: !!omap + - bigg.metabolite: pchol_cho - chebi: CHEBI:11230 - kegg.compound: C04230 - metanetx.chemical: MNXM96952 @@ -686,6 +745,7 @@ - formula: C11H12NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: 3ig3p - chebi: CHEBI:60820 - kegg.compound: C03506 - metanetx.chemical: MNXM163633 @@ -697,6 +757,7 @@ - formula: C7H9N2O - charge: 1 - annotation: !!omap + - bigg.metabolite: 1mncam - chebi: CHEBI:16797 - kegg.compound: C02918 - metanetx.chemical: MNXM2172 @@ -708,6 +769,7 @@ - formula: C9H15O9P - charge: -1 - annotation: !!omap + - bigg.metabolite: pail_cho - chebi: CHEBI:57880 - kegg.compound: C01194 - metanetx.chemical: MNXM62 @@ -719,9 +781,10 @@ - formula: C5H6NO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 1p3h5c - chebi: CHEBI:58509 - kegg.compound: C04281 - - metanetx.chemical: MNXM848 + - metanetx.chemical: MNXM114091 - sbo: SBO:0000247 - !!omap - id: s_0117 @@ -730,9 +793,10 @@ - formula: C5H6NO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 1p3h5c - chebi: CHEBI:58509 - kegg.compound: C04281 - - metanetx.chemical: MNXM848 + - metanetx.chemical: MNXM114091 - sbo: SBO:0000247 - !!omap - id: s_0118 @@ -741,6 +805,7 @@ - formula: C5H6NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: 1pyr5c - chebi: CHEBI:15893 - kegg.compound: C04322 - metanetx.chemical: MNXM1617 @@ -752,6 +817,7 @@ - formula: C5H6NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: 1pyr5c - chebi: CHEBI:15893 - kegg.compound: C04322 - metanetx.chemical: MNXM1617 @@ -763,6 +829,7 @@ - formula: C20H21N7O7 - charge: -2 - annotation: !!omap + - bigg.metabolite: 10fthf - chebi: CHEBI:57454 - kegg.compound: C00234 - metanetx.chemical: MNXM237 @@ -774,6 +841,7 @@ - formula: C20H21N7O7 - charge: -2 - annotation: !!omap + - bigg.metabolite: 10fthf - chebi: CHEBI:57454 - kegg.compound: C00234 - metanetx.chemical: MNXM237 @@ -785,6 +853,7 @@ - formula: C29H48O - charge: 0 - annotation: !!omap + - bigg.metabolite: 44mzym - chebi: CHEBI:18364 - kegg.compound: C05108 - metanetx.chemical: MNXM913 @@ -796,6 +865,7 @@ - formula: C6H8O18P4 - charge: -8 - annotation: !!omap + - bigg.metabolite: mi1345p - chebi: CHEBI:57895 - kegg.compound: C01272 - metanetx.chemical: MNXM624 @@ -807,6 +877,7 @@ - formula: C6H8O18P4 - charge: -8 - annotation: !!omap + - bigg.metabolite: mi3456p - chebi: CHEBI:57627 - kegg.compound: C11555 - metanetx.chemical: MNXM1620 @@ -818,6 +889,7 @@ - formula: C6H9O15P3 - charge: -6 - annotation: !!omap + - bigg.metabolite: mi145p - chebi: CHEBI:203600 - kegg.compound: C01245 - metanetx.chemical: MNXM200 @@ -829,6 +901,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: mi1p__D - chebi: CHEBI:58433 - kegg.compound: C01177 - metanetx.chemical: MNXM646 @@ -840,6 +913,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: mi1p__D - chebi: CHEBI:58433 - kegg.compound: C01177 - metanetx.chemical: MNXM646 @@ -851,6 +925,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: mi3p__D - chebi: CHEBI:58401 - kegg.compound: C04006 - metanetx.chemical: MNXM540 @@ -862,6 +937,7 @@ - formula: C10H11N5O6P - charge: -1 - annotation: !!omap + - bigg.metabolite: 23camp - chebi: CHEBI:60879 - kegg.compound: C02353 - metanetx.chemical: MNXM2598 @@ -873,6 +949,7 @@ - formula: C10H13N5O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: dad_2 - chebi: CHEBI:17256 - kegg.compound: C00559 - metanetx.chemical: MNXM625 @@ -884,6 +961,7 @@ - formula: C10H13N5O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: dad_2 - chebi: CHEBI:17256 - kegg.compound: C00559 - metanetx.chemical: MNXM625 @@ -895,6 +973,7 @@ - formula: C10H13N5O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: dgsn - chebi: CHEBI:17172 - kegg.compound: C00330 - metanetx.chemical: MNXM647 @@ -906,6 +985,7 @@ - formula: C10H13N5O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: dgsn - chebi: CHEBI:17172 - kegg.compound: C00330 - metanetx.chemical: MNXM647 @@ -917,6 +997,7 @@ - formula: C10H12N4O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: din - chebi: CHEBI:28997 - kegg.compound: C05512 - metanetx.chemical: MNXM935 @@ -928,6 +1009,7 @@ - formula: C10H12N4O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: din - chebi: CHEBI:28997 - kegg.compound: C05512 - metanetx.chemical: MNXM935 @@ -939,6 +1021,7 @@ - formula: C9H12N2O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: duri - chebi: CHEBI:16450 - kegg.compound: C00526 - metanetx.chemical: MNXM492 @@ -950,6 +1033,7 @@ - formula: C9H12N2O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: duri - chebi: CHEBI:16450 - kegg.compound: C00526 - metanetx.chemical: MNXM492 @@ -961,6 +1045,7 @@ - formula: C3H3O10P2 - charge: -5 - annotation: !!omap + - bigg.metabolite: 23dpg - chebi: CHEBI:58248 - kegg.compound: C01159 - metanetx.chemical: MNXM892 @@ -972,6 +1057,7 @@ - formula: C9H14N5O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: 25drapp - chebi: CHEBI:58614 - kegg.compound: C01304 - metanetx.chemical: MNXM648 @@ -980,10 +1066,12 @@ - id: s_0142 - name: 2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone - compartment: c - - formula: C9H18N5O8P - - charge: 0 + - formula: C9H16N5O8P + - charge: -2 - annotation: !!omap + - bigg.metabolite: 25dthpp - chebi: CHEBI:52957 + - kegg.compound: C18910 - metanetx.chemical: MNXM1099 - sbo: SBO:0000247 - !!omap @@ -993,6 +1081,7 @@ - formula: C10H16N4O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: caphis - chebi: CHEBI:17144 - kegg.compound: C04441 - metanetx.chemical: MNXM3804 @@ -1004,6 +1093,7 @@ - formula: C11H18N4O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: cmaphis - chebi: CHEBI:57784 - kegg.compound: C04692 - metanetx.chemical: MNXM3805 @@ -1015,6 +1105,7 @@ - formula: C7H10NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: acg5sa - chebi: CHEBI:29123 - kegg.compound: C01250 - metanetx.chemical: MNXM1062 @@ -1034,10 +1125,12 @@ - id: s_0147 - name: 2-amino-3-carboxymuconate-6-semialdehyde - compartment: c - - formula: C7H5NO5 - - charge: -2 + - formula: C7H6NO5 + - charge: -1 - annotation: !!omap + - bigg.metabolite: cmusa - chebi: CHEBI:29044 + - kegg.compound: C04409 - metanetx.chemical: MNXM1372 - sbo: SBO:0000247 - !!omap @@ -1047,6 +1140,7 @@ - formula: C7H9N5O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: 6hmhpt - chebi: CHEBI:17083 - kegg.compound: C01300 - metanetx.chemical: MNXM937 @@ -1058,6 +1152,7 @@ - formula: C6H9O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 2dhp - chebi: CHEBI:11561 - kegg.compound: C00966 - metanetx.chemical: MNXM959 @@ -1069,6 +1164,7 @@ - formula: C6H9O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 2dhp - chebi: CHEBI:11561 - kegg.compound: C00966 - metanetx.chemical: MNXM959 @@ -1080,6 +1176,7 @@ - formula: C5H10O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: drib - chebi: CHEBI:28816 - kegg.compound: C01801 - metanetx.chemical: MNXM2474 @@ -1091,6 +1188,7 @@ - formula: C5H9O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: 2dr5p - chebi: CHEBI:57651 - kegg.compound: C00673 - metanetx.chemical: MNXM2179 @@ -1102,6 +1200,7 @@ - formula: C38H56O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: 2hpmhmbq - chebi: CHEBI:28753 - kegg.compound: C05805 - metanetx.chemical: MNXM5466 @@ -1113,6 +1212,7 @@ - formula: C37H54O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: 2hp6mbq - chebi: CHEBI:27752 - kegg.compound: C05803 - metanetx.chemical: MNXM6707 @@ -1124,6 +1224,7 @@ - formula: C38H56O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: 2hpmmbq - chebi: CHEBI:28711 - kegg.compound: C05804 - metanetx.chemical: MNXM6067 @@ -1135,6 +1236,7 @@ - formula: C37H56O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: 2hp6mp - chebi: CHEBI:1109 - kegg.compound: C05802 - metanetx.chemical: MNXM4291 @@ -1143,9 +1245,10 @@ - id: s_0158 - name: 2-hydroxy-3-oxobutyl phosphate - compartment: c - - formula: C4H9O6P - - charge: 0 + - formula: C4H7O6P + - charge: -2 - annotation: !!omap + - bigg.metabolite: db4p - chebi: CHEBI:50606 - kegg.compound: C15556 - metanetx.chemical: MNXM2323 @@ -1157,6 +1260,7 @@ - formula: C16H32O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: 2hhxdal - chebi: CHEBI:50626 - metanetx.chemical: MNXM35167 - sbo: SBO:0000247 @@ -1167,6 +1271,7 @@ - formula: C7H10O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: 3c3hmp - chebi: CHEBI:28107 - kegg.compound: C02504 - metanetx.chemical: MNXM164143 @@ -1178,6 +1283,7 @@ - formula: C7H10O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: 3c3hmp - chebi: CHEBI:28107 - kegg.compound: C02504 - metanetx.chemical: MNXM164143 @@ -1189,6 +1295,7 @@ - formula: C7H10O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: 3c3hmp - chebi: CHEBI:28107 - kegg.compound: C02504 - metanetx.chemical: MNXM164143 @@ -1200,6 +1307,7 @@ - formula: C7H8O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: 2ippm - chebi: CHEBI:58085 - kegg.compound: C02631 - metanetx.chemical: MNXM1706 @@ -1211,6 +1319,7 @@ - formula: C5H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mbald - chebi: CHEBI:16182 - kegg.compound: C02223 - metanetx.chemical: MNXM2604 @@ -1222,6 +1331,7 @@ - formula: C5H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mbald - chebi: CHEBI:16182 - kegg.compound: C02223 - metanetx.chemical: MNXM2604 @@ -1233,6 +1343,7 @@ - formula: C5H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mbald - chebi: CHEBI:16182 - kegg.compound: C02223 - metanetx.chemical: MNXM2604 @@ -1244,6 +1355,7 @@ - formula: C5H12O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mbtoh - chebi: CHEBI:48945 - metanetx.chemical: MNXM5476 - sbo: SBO:0000247 @@ -1254,6 +1366,7 @@ - formula: C5H12O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mbtoh - chebi: CHEBI:48945 - metanetx.chemical: MNXM5476 - sbo: SBO:0000247 @@ -1264,6 +1377,7 @@ - formula: C5H12O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mbtoh - chebi: CHEBI:48945 - metanetx.chemical: MNXM5476 - sbo: SBO:0000247 @@ -1274,6 +1388,7 @@ - formula: C7H14O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mbac - chebi: CHEBI:50585 - metanetx.chemical: MNXM35277 - sbo: SBO:0000247 @@ -1284,6 +1399,7 @@ - formula: C7H14O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mbac - chebi: CHEBI:50585 - metanetx.chemical: MNXM35277 - sbo: SBO:0000247 @@ -1294,6 +1410,7 @@ - formula: C7H7O7 - charge: -3 - annotation: !!omap + - bigg.metabolite: 2mcit - chebi: CHEBI:15598 - kegg.compound: C02225 - metanetx.chemical: MNXM90279 @@ -1305,6 +1422,7 @@ - formula: C6H6O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: 2oxoadp - chebi: CHEBI:57499 - kegg.compound: C00322 - metanetx.chemical: MNXM263 @@ -1316,6 +1434,7 @@ - formula: C6H6O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: 2oxoadp - chebi: CHEBI:57499 - kegg.compound: C00322 - metanetx.chemical: MNXM263 @@ -1327,6 +1446,7 @@ - formula: C4H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 2obut - chebi: CHEBI:16763 - kegg.compound: C00109 - metanetx.chemical: MNXM159 @@ -1338,6 +1458,7 @@ - formula: C4H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 2obut - chebi: CHEBI:16763 - kegg.compound: C00109 - metanetx.chemical: MNXM159 @@ -1349,6 +1470,7 @@ - formula: C5H4O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: akg - chebi: CHEBI:16810 - kegg.compound: C00026 - metanetx.chemical: MNXM20 @@ -1360,6 +1482,7 @@ - formula: C5H4O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: akg - chebi: CHEBI:16810 - kegg.compound: C00026 - metanetx.chemical: MNXM20 @@ -1371,6 +1494,7 @@ - formula: C5H4O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: akg - chebi: CHEBI:16810 - kegg.compound: C00026 - metanetx.chemical: MNXM20 @@ -1382,6 +1506,7 @@ - formula: C5H4O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: akg - chebi: CHEBI:16810 - kegg.compound: C00026 - metanetx.chemical: MNXM20 @@ -1393,6 +1518,7 @@ - formula: C5H4O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: akg - chebi: CHEBI:16810 - kegg.compound: C00026 - metanetx.chemical: MNXM20 @@ -1404,6 +1530,7 @@ - formula: C8H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2phetoh - chebi: CHEBI:49000 - kegg.compound: C05853 - metanetx.chemical: MNXM2476 @@ -1415,6 +1542,7 @@ - formula: C8H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2phetoh - chebi: CHEBI:49000 - kegg.compound: C05853 - metanetx.chemical: MNXM2476 @@ -1426,6 +1554,7 @@ - formula: C8H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2phetoh - chebi: CHEBI:49000 - kegg.compound: C05853 - metanetx.chemical: MNXM2476 @@ -1437,6 +1566,7 @@ - formula: C3H4O7P - charge: -3 - annotation: !!omap + - bigg.metabolite: 2pg - chebi: CHEBI:58289 - kegg.compound: C00631 - metanetx.chemical: MNXM275 @@ -1448,6 +1578,7 @@ - formula: C20H33O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ggdp - chebi: CHEBI:58756 - kegg.compound: C00353 - metanetx.chemical: MNXM139 @@ -1459,6 +1590,7 @@ - formula: C15H25O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: frdp - chebi: CHEBI:175763 - kegg.compound: C00448 - metanetx.chemical: MNXM34 @@ -1470,6 +1602,7 @@ - formula: C15H25O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: frdp - chebi: CHEBI:175763 - kegg.compound: C00448 - metanetx.chemical: MNXM34 @@ -1481,6 +1614,7 @@ - formula: C10H11N5O6P - charge: -1 - annotation: !!omap + - bigg.metabolite: camp - chebi: CHEBI:58165 - kegg.compound: C00575 - metanetx.chemical: MNXM243 @@ -1492,6 +1626,7 @@ - formula: C9H11N3O7P - charge: -1 - annotation: !!omap + - bigg.metabolite: 35ccmp - chebi: CHEBI:58003 - kegg.compound: C00941 - metanetx.chemical: MNXM3162 @@ -1500,9 +1635,10 @@ - id: s_0194 - name: 3',5'-cyclic dAMP - compartment: c - - formula: C10H12N5O5P - - charge: 0 + - formula: C10H11N5O5P + - charge: -1 - annotation: !!omap + - bigg.metabolite: 35cdamp - chebi: CHEBI:28074 - kegg.compound: C00968 - metanetx.chemical: MNXM9931 @@ -1514,6 +1650,7 @@ - formula: C10H11N5O7P - charge: -1 - annotation: !!omap + - bigg.metabolite: 35cgmp - chebi: CHEBI:57746 - kegg.compound: C00942 - metanetx.chemical: MNXM665 @@ -1522,9 +1659,10 @@ - id: s_0196 - name: 3',5'-cyclic IMP - compartment: c - - formula: C10H11N4O7P - - charge: 0 + - formula: C10H10N4O7P + - charge: -1 - annotation: !!omap + - bigg.metabolite: 35cimp - chebi: CHEBI:27541 - kegg.compound: C00943 - metanetx.chemical: MNXM9932 @@ -1536,6 +1674,7 @@ - formula: C21H33N7O13P2S - charge: -2 - annotation: !!omap + - bigg.metabolite: dpcoa - chebi: CHEBI:57328 - kegg.compound: C00882 - metanetx.chemical: MNXM481 @@ -1547,6 +1686,7 @@ - formula: C21H33N7O13P2S - charge: -2 - annotation: !!omap + - bigg.metabolite: dpcoa - chebi: CHEBI:57328 - kegg.compound: C00882 - metanetx.chemical: MNXM481 @@ -1558,6 +1698,7 @@ - formula: C10H11N5O13P2S - charge: -4 - annotation: !!omap + - bigg.metabolite: paps - chebi: CHEBI:58339 - kegg.compound: C00053 - metanetx.chemical: MNXM49 @@ -1569,6 +1710,7 @@ - formula: C9H7O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 34hpp - chebi: CHEBI:36242 - kegg.compound: C01179 - metanetx.chemical: MNXM153 @@ -1580,6 +1722,7 @@ - formula: C9H7O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 34hpp - chebi: CHEBI:36242 - kegg.compound: C01179 - metanetx.chemical: MNXM153 @@ -1591,6 +1734,7 @@ - formula: C6H7N2O5P - charge: -2 - annotation: !!omap + - bigg.metabolite: imacp - chebi: CHEBI:57766 - kegg.compound: C01267 - metanetx.chemical: MNXM1456 @@ -1602,6 +1746,7 @@ - formula: C3H8NO - charge: 1 - annotation: !!omap + - bigg.metabolite: aproa - chebi: CHEBI:58374 - kegg.compound: C02229 - metanetx.chemical: MNXM493 @@ -1624,6 +1769,7 @@ - formula: C7H9O6 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3dhq - chebi: CHEBI:32364 - kegg.compound: C00944 - metanetx.chemical: MNXM478 @@ -1635,6 +1781,7 @@ - formula: C7H7O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3dhsk - chebi: CHEBI:16630 - kegg.compound: C02637 - metanetx.chemical: MNXM611 @@ -1646,6 +1793,7 @@ - formula: C37H53O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3dh5hpb - chebi: CHEBI:58373 - kegg.compound: C05200 - metanetx.chemical: MNXM2783 @@ -1657,6 +1805,7 @@ - formula: C37H53O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3dh5hpb - chebi: CHEBI:58373 - kegg.compound: C05200 - metanetx.chemical: MNXM2783 @@ -1668,6 +1817,7 @@ - formula: C38H55O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3hph5mb - chebi: CHEBI:57916 - kegg.compound: C05313 - metanetx.chemical: MNXM3166 @@ -1676,9 +1826,10 @@ - id: s_0215 - name: 3-hexaprenyl-4-hydroxybenzoic acid - compartment: c - - formula: C37H54O3 - - charge: 0 + - formula: C37H53O3 + - charge: -1 - annotation: !!omap + - bigg.metabolite: 3ophb_5 - chebi: CHEBI:31116 - kegg.compound: C13425 - metanetx.chemical: MNXM3167 @@ -1687,9 +1838,10 @@ - id: s_0216 - name: 3-hexaprenyl-4-hydroxybenzoic acid - compartment: m - - formula: C37H54O3 - - charge: 0 + - formula: C37H53O3 + - charge: -1 - annotation: !!omap + - bigg.metabolite: 3ophb_5 - chebi: CHEBI:31116 - kegg.compound: C13425 - metanetx.chemical: MNXM3167 @@ -1708,23 +1860,25 @@ - id: s_0218 - name: 3-hydroxy-3-methylglutaryl-CoA - compartment: c - - formula: C27H44N7O20P3S - - charge: 0 + - formula: C27H39N7O20P3S + - charge: -5 - annotation: !!omap + - bigg.metabolite: hmgcoa - chebi: CHEBI:11814 - kegg.compound: C00356 - - metanetx.chemical: MNXM36493 + - metanetx.chemical: MNXM197 - sbo: SBO:0000247 - !!omap - id: s_0221 - name: 3-hydroxy-3-methylglutaryl-CoA - compartment: m - - formula: C27H44N7O20P3S - - charge: 0 + - formula: C27H39N7O20P3S + - charge: -5 - annotation: !!omap + - bigg.metabolite: hmgcoa - chebi: CHEBI:11814 - kegg.compound: C00356 - - metanetx.chemical: MNXM36493 + - metanetx.chemical: MNXM197 - sbo: SBO:0000247 - !!omap - id: s_0222 @@ -1733,6 +1887,7 @@ - formula: C10H12N2O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: hLkynr - chebi: CHEBI:17380 - kegg.compound: C03227 - metanetx.chemical: MNXM576 @@ -1744,6 +1899,7 @@ - formula: C7H6NO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3hanthrn - chebi: CHEBI:36559 - kegg.compound: C00632 - metanetx.chemical: MNXM359 @@ -1752,9 +1908,10 @@ - id: s_0229 - name: 3-hydroxyoctadecanoyl-CoA - compartment: p - - formula: C39H70N7O18P3S - - charge: 0 + - formula: C39H66N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2248 - chebi: CHEBI:50583 - kegg.compound: C16217 - metanetx.chemical: MNXM1309 @@ -1766,6 +1923,7 @@ - formula: C18H38NO2 - charge: 1 - annotation: !!omap + - bigg.metabolite: 3dsphgn - chebi: CHEBI:58299 - kegg.compound: C02934 - metanetx.chemical: MNXM559 @@ -1777,6 +1935,7 @@ - formula: C5H7O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3mob - chebi: CHEBI:11851 - kegg.compound: C00141 - metanetx.chemical: MNXM238 @@ -1788,6 +1947,7 @@ - formula: C5H7O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3mob - chebi: CHEBI:11851 - kegg.compound: C00141 - metanetx.chemical: MNXM238 @@ -1799,6 +1959,7 @@ - formula: C5H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 3mbald - chebi: CHEBI:16638 - kegg.compound: C07329 - metanetx.chemical: MNXM5280 @@ -1810,6 +1971,7 @@ - formula: C5H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 3mbald - chebi: CHEBI:16638 - kegg.compound: C07329 - metanetx.chemical: MNXM5280 @@ -1821,6 +1983,7 @@ - formula: C5H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 3mbald - chebi: CHEBI:16638 - kegg.compound: C07329 - metanetx.chemical: MNXM5280 @@ -1829,9 +1992,10 @@ - id: s_0239 - name: 3-oxodecanoyl-CoA - compartment: p - - formula: C31H52N7O18P3S - - charge: 0 + - formula: C31H48N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3odcoa - chebi: CHEBI:28528 - kegg.compound: C05265 - metanetx.chemical: MNXM677 @@ -1840,9 +2004,10 @@ - id: s_0243 - name: 3-oxohexacosanoyl-CoA - compartment: p - - formula: C47H84N7O18P3S - - charge: 0 + - formula: C47H80N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3ohxccoa - chebi: CHEBI:52977 - metanetx.chemical: MNXM36758 - sbo: SBO:0000247 @@ -1850,9 +2015,10 @@ - id: s_0247 - name: 3-oxolauroyl-CoA - compartment: p - - formula: C33H56N7O18P3S - - charge: 0 + - formula: C33H52N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3oddcoa - chebi: CHEBI:27868 - kegg.compound: C05263 - metanetx.chemical: MNXM705 @@ -1861,9 +2027,10 @@ - id: s_0250 - name: 3-oxooctadecanoyl-CoA - compartment: p - - formula: C39H68N7O18P3S - - charge: 0 + - formula: C39H64N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3ohodcoa - chebi: CHEBI:50571 - kegg.compound: C16216 - metanetx.chemical: MNXM513 @@ -1875,6 +2042,7 @@ - formula: C37H60N7O18P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: 3ohdcoa - chebi: CHEBI:57349 - kegg.compound: C05259 - metanetx.chemical: MNXM738 @@ -1883,9 +2051,10 @@ - id: s_0257 - name: 3-oxotetradecanoyl-CoA - compartment: p - - formula: C35H60N7O18P3S - - charge: 0 + - formula: C35H56N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3otdcoa - chebi: CHEBI:28726 - kegg.compound: C05261 - metanetx.chemical: MNXM707 @@ -1897,6 +2066,7 @@ - formula: C3H2O7P - charge: -3 - annotation: !!omap + - bigg.metabolite: 3php - chebi: CHEBI:18110 - kegg.compound: C03232 - metanetx.chemical: MNXM541 @@ -1908,6 +2078,7 @@ - formula: C3H6NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: pser__L - chebi: CHEBI:57524 - kegg.compound: C01005 - metanetx.chemical: MNXM379 @@ -1919,6 +2090,7 @@ - formula: C3H4O7P - charge: -3 - annotation: !!omap + - bigg.metabolite: 3pg - chebi: CHEBI:58272 - kegg.compound: C00197 - metanetx.chemical: MNXM126 @@ -1930,6 +2102,7 @@ - formula: C7H8O8P - charge: -3 - annotation: !!omap + - bigg.metabolite: skm5p - chebi: CHEBI:145989 - kegg.compound: C03175 - metanetx.chemical: MNXM1265 @@ -1941,6 +2114,7 @@ - formula: C29H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: 44mctr - chebi: CHEBI:17813 - kegg.compound: C11455 - metanetx.chemical: MNXM1036 @@ -1949,8 +2123,8 @@ - id: s_0263 - name: 4,5-bis(diphospho)-1D-myo-inositol tetrakisphosphate - compartment: c - - formula: C6H20O30P8 - - charge: 0 + - formula: C6H7O30P8 + - charge: -13 - annotation: !!omap - chebi: CHEBI:53066 - metanetx.chemical: MNXM484827 @@ -1962,6 +2136,7 @@ - formula: C4H8NO7P - charge: -2 - annotation: !!omap + - bigg.metabolite: phthr - chebi: CHEBI:58452 - kegg.compound: C06055 - metanetx.chemical: MNXM759 @@ -1973,6 +2148,7 @@ - formula: C6H8N3O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: 2mahmp - chebi: CHEBI:57841 - kegg.compound: C04752 - metanetx.chemical: MNXM1135 @@ -1984,6 +2160,7 @@ - formula: C6H8N3O4P - charge: -2 - annotation: !!omap + - bigg.metabolite: 4ampm - chebi: CHEBI:58354 - kegg.compound: C04556 - metanetx.chemical: MNXM790 @@ -1992,9 +2169,10 @@ - id: s_0269 - name: 4-amino-4-deoxychorismate - compartment: c - - formula: C10H9NO5 - - charge: -2 + - formula: C10H10NO5 + - charge: -1 - annotation: !!omap + - bigg.metabolite: 4adcho - chebi: CHEBI:35181 - kegg.compound: C11355 - metanetx.chemical: MNXM1458 @@ -2006,6 +2184,7 @@ - formula: C6H9N3O - charge: 0 - annotation: !!omap + - bigg.metabolite: 4ahmmp - chebi: CHEBI:16892 - kegg.compound: C01279 - metanetx.chemical: MNXM874 @@ -2017,6 +2196,7 @@ - formula: C7H6NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: 4abz - chebi: CHEBI:17836 - kegg.compound: C00568 - metanetx.chemical: MNXM421 @@ -2028,6 +2208,7 @@ - formula: C7H6NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: 4abz - chebi: CHEBI:17836 - kegg.compound: C00568 - metanetx.chemical: MNXM421 @@ -2039,6 +2220,7 @@ - formula: C7H6NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: 4abz - chebi: CHEBI:17836 - kegg.compound: C00568 - metanetx.chemical: MNXM421 @@ -2050,6 +2232,7 @@ - formula: C4H10NO - charge: 1 - annotation: !!omap + - bigg.metabolite: 4abutn - chebi: CHEBI:58264 - kegg.compound: C00555 - metanetx.chemical: MNXM422 @@ -2061,6 +2244,7 @@ - formula: C4H10NO - charge: 1 - annotation: !!omap + - bigg.metabolite: 4abutn - chebi: CHEBI:58264 - kegg.compound: C00555 - metanetx.chemical: MNXM422 @@ -2069,11 +2253,12 @@ - id: s_0279 - name: 4-diphospho-1D-myo-inositol pentakisphosphate - compartment: c - - formula: C6H19O27P7 - - charge: 0 + - formula: C6H6O27P7 + - charge: -13 - annotation: !!omap - chebi: CHEBI:53064 - - metanetx.chemical: MNXM37435 + - kegg.compound: C11526 + - metanetx.chemical: MNXM1715 - sbo: SBO:0000247 - !!omap - id: s_0280 @@ -2082,6 +2267,7 @@ - formula: C5H13N4O - charge: 1 - annotation: !!omap + - bigg.metabolite: 4gudbd - chebi: CHEBI:58365 - kegg.compound: C03078 - metanetx.chemical: MNXM2617 @@ -2093,6 +2279,7 @@ - formula: C5H11N3O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: 4gudbutn - chebi: CHEBI:15728 - kegg.compound: C01035 - metanetx.chemical: MNXM1312 @@ -2104,6 +2291,7 @@ - formula: C5H4O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: 4h2oglt - chebi: CHEBI:17742 - kegg.compound: C01127 - metanetx.chemical: MNXM894 @@ -2115,6 +2303,7 @@ - formula: C5H4O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: 4h2oglt - chebi: CHEBI:17742 - kegg.compound: C01127 - metanetx.chemical: MNXM894 @@ -2126,6 +2315,7 @@ - formula: C5H4O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: 4h2oglt - chebi: CHEBI:17742 - kegg.compound: C01127 - metanetx.chemical: MNXM894 @@ -2137,6 +2327,7 @@ - formula: C4H9NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: 4hthr - chebi: CHEBI:28330 - kegg.compound: C06056 - metanetx.chemical: MNXM1802 @@ -2148,6 +2339,7 @@ - formula: C7H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 4hbz - chebi: CHEBI:17879 - kegg.compound: C00156 - metanetx.chemical: MNXM164 @@ -2159,6 +2351,7 @@ - formula: C7H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 4hbz - chebi: CHEBI:17879 - kegg.compound: C00156 - metanetx.chemical: MNXM164 @@ -2170,6 +2363,7 @@ - formula: C28H36N7O18P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: 4hbzcoa - chebi: CHEBI:57356 - kegg.compound: C02949 - metanetx.chemical: MNXM739 @@ -2181,6 +2375,7 @@ - formula: C6H9O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 4mop - chebi: CHEBI:17865 - kegg.compound: C00233 - metanetx.chemical: MNXM404 @@ -2192,6 +2387,7 @@ - formula: C6H9O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 4mop - chebi: CHEBI:17865 - kegg.compound: C00233 - metanetx.chemical: MNXM404 @@ -2203,6 +2399,7 @@ - formula: C6H8NO4PS - charge: -2 - annotation: !!omap + - bigg.metabolite: 4mpetz - chebi: CHEBI:58296 - kegg.compound: C04327 - metanetx.chemical: MNXM960 @@ -2214,6 +2411,7 @@ - formula: C5H7O3S - charge: -1 - annotation: !!omap + - bigg.metabolite: 4met2obut - chebi: CHEBI:16723 - kegg.compound: C01180 - metanetx.chemical: MNXM276 @@ -2222,9 +2420,10 @@ - id: s_0295 - name: 4-phospho-L-aspartate - compartment: c - - formula: C4H5NO7P - - charge: -3 + - formula: C4H6NO7P + - charge: -2 - annotation: !!omap + - bigg.metabolite: 4pasp - chebi: CHEBI:30407 - kegg.compound: C03082 - metanetx.chemical: MNXM1177 @@ -2236,6 +2435,7 @@ - formula: C28H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: 4mzym - chebi: CHEBI:1949 - kegg.compound: C05103 - metanetx.chemical: MNXM1804 @@ -2244,8 +2444,8 @@ - id: s_0297 - name: 4beta-methylzymosterol-4alpha-carboxylic acid - compartment: c - - formula: C29H46O3 - - charge: 0 + - formula: C29H45O3 + - charge: -1 - annotation: !!omap - chebi: CHEBI:50591 - kegg.compound: C15808 @@ -2258,6 +2458,7 @@ - formula: C10H12N5O10PS - charge: -2 - annotation: !!omap + - bigg.metabolite: aps - chebi: CHEBI:58243 - kegg.compound: C00224 - metanetx.chemical: MNXM287 @@ -2269,6 +2470,7 @@ - formula: C13H15N4O12P - charge: -4 - annotation: !!omap + - bigg.metabolite: 25aics - chebi: CHEBI:58443 - kegg.compound: C04823 - metanetx.chemical: MNXM607 @@ -2280,9 +2482,10 @@ - formula: C8H13N3O7P - charge: -1 - annotation: !!omap + - bigg.metabolite: air - chebi: CHEBI:58592 - kegg.compound: C03373 - - metanetx.chemical: MNXM162266 + - metanetx.chemical: MNXM388 - sbo: SBO:0000247 - !!omap - id: s_0301 @@ -2291,6 +2494,7 @@ - formula: C8H13N2O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: fgam - chebi: CHEBI:58426 - kegg.compound: C04376 - metanetx.chemical: MNXM453 @@ -2302,6 +2506,7 @@ - formula: C8H15N3O8P - charge: -1 - annotation: !!omap + - bigg.metabolite: fpram - chebi: CHEBI:58478 - kegg.compound: C04640 - metanetx.chemical: MNXM568 @@ -2313,6 +2518,7 @@ - formula: C11H15N5O3S - charge: 0 - annotation: !!omap + - bigg.metabolite: 5mta - chebi: CHEBI:17509 - kegg.compound: C00170 - metanetx.chemical: MNXM150 @@ -2324,6 +2530,7 @@ - formula: C20H20N7O6 - charge: -1 - annotation: !!omap + - bigg.metabolite: methf - chebi: CHEBI:57455 - kegg.compound: C00445 - metanetx.chemical: MNXM511 @@ -2335,6 +2542,7 @@ - formula: C20H20N7O6 - charge: -1 - annotation: !!omap + - bigg.metabolite: methf - chebi: CHEBI:57455 - kegg.compound: C00445 - metanetx.chemical: MNXM511 @@ -2346,9 +2554,10 @@ - formula: C20H21N7O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: mlthf - chebi: CHEBI:12071 - kegg.compound: C00143 - - metanetx.chemical: MNXM90098 + - metanetx.chemical: MNXM183 - sbo: SBO:0000247 - !!omap - id: s_0307 @@ -2357,27 +2566,29 @@ - formula: C20H21N7O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: mlthf - chebi: CHEBI:12071 - kegg.compound: C00143 - - metanetx.chemical: MNXM90098 + - metanetx.chemical: MNXM183 - sbo: SBO:0000247 - !!omap - id: s_0308 - name: 5,6,7,8-tetrahydrofolyl-L-glutamic acid - compartment: c - - formula: C24H30N8O9 - - charge: 0 + - formula: C24H27N8O9 + - charge: -3 - annotation: !!omap + - bigg.metabolite: thfglu - chebi: CHEBI:27650 - kegg.compound: C09332 - - metanetx.chemical: MNXM317 + - metanetx.chemical: MNXM723480 - sbo: SBO:0000247 - !!omap - id: s_0309 - name: 5,6-bis(diphospho)-1D-myo-inositol tetrakisphosphate - compartment: c - - formula: C6H20O30P8 - - charge: 0 + - formula: C6H7O30P8 + - charge: -13 - annotation: !!omap - chebi: CHEBI:52965 - metanetx.chemical: MNXM487477 @@ -2389,6 +2600,7 @@ - formula: C6H9NOS - charge: 0 - annotation: !!omap + - bigg.metabolite: 4mhetz - chebi: CHEBI:17957 - kegg.compound: C04294 - metanetx.chemical: MNXM962 @@ -2400,6 +2612,7 @@ - formula: C6H9O6PS - charge: -2 - annotation: !!omap + - bigg.metabolite: dkmpp - chebi: CHEBI:58828 - kegg.compound: C15650 - metanetx.chemical: MNXM162358 @@ -2411,6 +2624,7 @@ - formula: C15H21N5O15P2 - charge: -4 - annotation: !!omap + - bigg.metabolite: prlp - chebi: CHEBI:58525 - kegg.compound: C04916 - metanetx.chemical: MNXM1408 @@ -2422,6 +2636,7 @@ - formula: C9H15N4O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: 5aprbu - chebi: CHEBI:58421 - kegg.compound: C04454 - metanetx.chemical: MNXM1178 @@ -2433,6 +2648,7 @@ - formula: C9H16N4O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: 4r5au - chebi: CHEBI:15934 - kegg.compound: C04732 - metanetx.chemical: MNXM791 @@ -2444,6 +2660,7 @@ - formula: C5H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: 5aop - chebi: CHEBI:17549 - kegg.compound: C00430 - metanetx.chemical: MNXM405 @@ -2455,6 +2672,7 @@ - formula: C5H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: 5aop - chebi: CHEBI:17549 - kegg.compound: C00430 - metanetx.chemical: MNXM405 @@ -2466,6 +2684,7 @@ - formula: C5H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: 5aop - chebi: CHEBI:17549 - kegg.compound: C00430 - metanetx.chemical: MNXM405 @@ -2477,6 +2696,7 @@ - formula: C6H6O27P7 - charge: -13 - annotation: !!omap + - bigg.metabolite: ppmi12346p - chebi: CHEBI:58628 - kegg.compound: C11526 - metanetx.chemical: MNXM1715 @@ -2488,6 +2708,7 @@ - formula: C20H21N7O7 - charge: -2 - annotation: !!omap + - bigg.metabolite: 5fthf - chebi: CHEBI:57457 - kegg.compound: C03479 - metanetx.chemical: MNXM1392 @@ -2499,6 +2720,7 @@ - formula: C20H21N7O7 - charge: -2 - annotation: !!omap + - bigg.metabolite: 5fthf - chebi: CHEBI:57457 - kegg.compound: C03479 - metanetx.chemical: MNXM1392 @@ -2510,6 +2732,7 @@ - formula: C20H21N7O7 - charge: -2 - annotation: !!omap + - bigg.metabolite: 5fthf - chebi: CHEBI:57457 - kegg.compound: C03479 - metanetx.chemical: MNXM1392 @@ -2521,6 +2744,7 @@ - formula: C20H23N7O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: 5mthf - chebi: CHEBI:18608 - kegg.compound: C00440 - metanetx.chemical: MNXM318 @@ -2532,6 +2756,7 @@ - formula: C30H35N9O12 - charge: -4 - annotation: !!omap + - bigg.metabolite: mhpglu - chebi: CHEBI:58207 - kegg.compound: C04489 - metanetx.chemical: MNXM2623 @@ -2543,6 +2768,7 @@ - formula: C10H9O10P - charge: -4 - annotation: !!omap + - bigg.metabolite: 3psme - chebi: CHEBI:57701 - kegg.compound: C01269 - metanetx.chemical: MNXM1365 @@ -2554,6 +2780,7 @@ - formula: C7H14N2O8P - charge: -1 - annotation: !!omap + - bigg.metabolite: gar - chebi: CHEBI:58457 - kegg.compound: C03838 - metanetx.chemical: MNXM463 @@ -2565,6 +2792,7 @@ - formula: C15H19N5O20P4 - charge: -6 - annotation: !!omap + - bigg.metabolite: prbatp - chebi: CHEBI:58424 - kegg.compound: C02739 - metanetx.chemical: MNXM1351 @@ -2576,6 +2804,7 @@ - formula: C5H11NO7P - charge: -1 - annotation: !!omap + - bigg.metabolite: pram - chebi: CHEBI:58681 - kegg.compound: C03090 - metanetx.chemical: MNXM90003 @@ -2587,6 +2816,7 @@ - formula: C13H17N4O6 - charge: -1 - annotation: !!omap + - bigg.metabolite: dmlz - chebi: CHEBI:58201 - kegg.compound: C04332 - metanetx.chemical: MNXM1313 @@ -2598,6 +2828,7 @@ - formula: C17H28NO17PR2 - charge: 0 - annotation: !!omap + - bigg.metabolite: gpail_hs - chebi: CHEBI:17049 - kegg.compound: C04248 - metanetx.chemical: MNXM1411 @@ -2615,12 +2846,13 @@ - id: s_0331 - name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol - compartment: er - - formula: C19H29NO18PR2 - - charge: -1 + - formula: C19H30NO18PR2 + - charge: 0 - annotation: !!omap + - bigg.metabolite: acgpail_hs - chebi: CHEBI:57265 - kegg.compound: C01288 - - metanetx.chemical: MNXM92477 + - metanetx.chemical: MNXM999 - sbo: SBO:0000247 - !!omap - id: s_0332 @@ -2636,11 +2868,12 @@ - id: s_0333 - name: 6-diphospho-1D-myo-inositol pentakisphosphate - compartment: c - - formula: C6H19O27P7 - - charge: 0 + - formula: C6H6O27P7 + - charge: -13 - annotation: !!omap - chebi: CHEBI:53065 - - metanetx.chemical: MNXM38670 + - kegg.compound: C11526 + - metanetx.chemical: MNXM1715 - sbo: SBO:0000247 - !!omap - id: s_0334 @@ -2658,6 +2891,7 @@ - formula: C6H9O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: 6pgl - chebi: CHEBI:57955 - kegg.compound: C01236 - metanetx.chemical: MNXM429 @@ -2696,6 +2930,7 @@ - formula: C6H10O10P - charge: -3 - annotation: !!omap + - bigg.metabolite: 6pgc - chebi: CHEBI:58759 - kegg.compound: C00345 - metanetx.chemical: MNXM325 @@ -2704,9 +2939,10 @@ - id: s_0341 - name: 7,8-diaminononanoate - compartment: c - - formula: C9H19N2O2 - - charge: -1 + - formula: C9H21N2O2 + - charge: 1 - annotation: !!omap + - bigg.metabolite: dann - chebi: CHEBI:17830 - kegg.compound: C01037 - metanetx.chemical: MNXM1140 @@ -2715,9 +2951,10 @@ - id: s_0342 - name: 7,8-diaminononanoate - compartment: e - - formula: C9H19N2O2 - - charge: -1 + - formula: C9H21N2O2 + - charge: 1 - annotation: !!omap + - bigg.metabolite: dann - chebi: CHEBI:17830 - kegg.compound: C01037 - metanetx.chemical: MNXM1140 @@ -2729,6 +2966,7 @@ - formula: C9H13N5O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: dhnpt - chebi: CHEBI:17001 - kegg.compound: C04874 - metanetx.chemical: MNXM162359 @@ -2740,6 +2978,7 @@ - formula: C9H13N5O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: dhnpt - chebi: CHEBI:17001 - kegg.compound: C04874 - metanetx.chemical: MNXM162359 @@ -2751,6 +2990,7 @@ - formula: C9H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: dhpmp - chebi: CHEBI:58762 - kegg.compound: C05925 - metanetx.chemical: MNXM1645 @@ -2762,6 +3002,7 @@ - formula: C9H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: ahdt - chebi: CHEBI:58462 - kegg.compound: C04895 - metanetx.chemical: MNXM397 @@ -2773,9 +3014,10 @@ - formula: C14H13N6O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: dhpt - chebi: CHEBI:17839 - kegg.compound: C00921 - - metanetx.chemical: MNXM965 + - metanetx.chemical: MNXM722728 - sbo: SBO:0000247 - !!omap - id: s_0348 @@ -2784,9 +3026,10 @@ - formula: C14H13N6O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: dhpt - chebi: CHEBI:17839 - kegg.compound: C00921 - - metanetx.chemical: MNXM965 + - metanetx.chemical: MNXM722728 - sbo: SBO:0000247 - !!omap - id: s_0349 @@ -2795,6 +3038,7 @@ - formula: C7H10O10P - charge: -3 - annotation: !!omap + - bigg.metabolite: 2dda7p - chebi: CHEBI:58394 - kegg.compound: C04691 - metanetx.chemical: MNXM1219 @@ -2806,6 +3050,7 @@ - formula: C7H10O10P - charge: -3 - annotation: !!omap + - bigg.metabolite: 2dda7p - chebi: CHEBI:58394 - kegg.compound: C04691 - metanetx.chemical: MNXM1219 @@ -2817,6 +3062,7 @@ - formula: C9H17NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: 8aonn - chebi: CHEBI:15830 - kegg.compound: C01092 - metanetx.chemical: MNXM1141 @@ -2828,6 +3074,7 @@ - formula: C9H17NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: 8aonn - chebi: CHEBI:15830 - kegg.compound: C01092 - metanetx.chemical: MNXM1141 @@ -2839,6 +3086,7 @@ - formula: C5H4N4O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: xan - chebi: CHEBI:17712 - kegg.compound: C00385 - metanetx.chemical: MNXM174 @@ -2850,6 +3098,7 @@ - formula: C5H4N4O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: xan - chebi: CHEBI:17712 - kegg.compound: C00385 - metanetx.chemical: MNXM174 @@ -2861,6 +3110,7 @@ - formula: C2H4O - charge: 0 - annotation: !!omap + - bigg.metabolite: acald - chebi: CHEBI:15343 - kegg.compound: C00084 - metanetx.chemical: MNXM75 @@ -2872,6 +3122,7 @@ - formula: C2H4O - charge: 0 - annotation: !!omap + - bigg.metabolite: acald - chebi: CHEBI:15343 - kegg.compound: C00084 - metanetx.chemical: MNXM75 @@ -2883,6 +3134,7 @@ - formula: C2H4O - charge: 0 - annotation: !!omap + - bigg.metabolite: acald - chebi: CHEBI:15343 - kegg.compound: C00084 - metanetx.chemical: MNXM75 @@ -2894,6 +3146,7 @@ - formula: C2H3O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ac - chebi: CHEBI:30089 - kegg.compound: C00033 - metanetx.chemical: MNXM26 @@ -2905,6 +3158,7 @@ - formula: C2H3O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ac - chebi: CHEBI:30089 - kegg.compound: C00033 - metanetx.chemical: MNXM26 @@ -2916,6 +3170,7 @@ - formula: C2H3O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ac - chebi: CHEBI:30089 - kegg.compound: C00033 - metanetx.chemical: MNXM26 @@ -2927,6 +3182,7 @@ - formula: C2H3O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ac - chebi: CHEBI:30089 - kegg.compound: C00033 - metanetx.chemical: MNXM26 @@ -2938,6 +3194,7 @@ - formula: C2H3O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ac - chebi: CHEBI:30089 - kegg.compound: C00033 - metanetx.chemical: MNXM26 @@ -2949,6 +3206,7 @@ - formula: C25H36N7O18P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: aacoa - chebi: CHEBI:57286 - kegg.compound: C00332 - metanetx.chemical: MNXM133 @@ -2960,6 +3218,7 @@ - formula: C25H36N7O18P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: aacoa - chebi: CHEBI:57286 - kegg.compound: C00332 - metanetx.chemical: MNXM133 @@ -2971,6 +3230,7 @@ - formula: C2H3OSR - charge: 0 - annotation: !!omap + - bigg.metabolite: acACP - chebi: CHEBI:17093 - kegg.compound: C03939 - metanetx.chemical: MNXM1269 @@ -2982,6 +3242,7 @@ - formula: C23H34N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: accoa - chebi: CHEBI:57288 - kegg.compound: C00024 - metanetx.chemical: MNXM21 @@ -2993,6 +3254,7 @@ - formula: C23H34N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: accoa - chebi: CHEBI:57288 - kegg.compound: C00024 - metanetx.chemical: MNXM21 @@ -3004,6 +3266,7 @@ - formula: C23H34N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: accoa - chebi: CHEBI:57288 - kegg.compound: C00024 - metanetx.chemical: MNXM21 @@ -3015,6 +3278,7 @@ - formula: C23H34N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: accoa - chebi: CHEBI:57288 - kegg.compound: C00024 - metanetx.chemical: MNXM21 @@ -3026,6 +3290,7 @@ - formula: C5H5N5 - charge: 0 - annotation: !!omap + - bigg.metabolite: ade - chebi: CHEBI:16708 - kegg.compound: C00147 - metanetx.chemical: MNXM168 @@ -3037,6 +3302,7 @@ - formula: C5H5N5 - charge: 0 - annotation: !!omap + - bigg.metabolite: ade - chebi: CHEBI:16708 - kegg.compound: C00147 - metanetx.chemical: MNXM168 @@ -3048,6 +3314,7 @@ - formula: C5H5N5 - charge: 0 - annotation: !!omap + - bigg.metabolite: ade - chebi: CHEBI:16708 - kegg.compound: C00147 - metanetx.chemical: MNXM168 @@ -3059,6 +3326,7 @@ - formula: C10H13N5O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: adn - chebi: CHEBI:16335 - kegg.compound: C00212 - metanetx.chemical: MNXM212 @@ -3070,6 +3338,7 @@ - formula: C10H13N5O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: adn - chebi: CHEBI:16335 - kegg.compound: C00212 - metanetx.chemical: MNXM212 @@ -3078,9 +3347,10 @@ - id: s_0389 - name: adenosine 2'-phosphate - compartment: c - - formula: C10H14N5O7P - - charge: 0 + - formula: C10H12N5O7P + - charge: -2 - annotation: !!omap + - bigg.metabolite: amp2p - chebi: CHEBI:28223 - kegg.compound: C00946 - metanetx.chemical: MNXM7028 @@ -3092,6 +3362,7 @@ - formula: C10H11N5O10P2 - charge: -4 - annotation: !!omap + - bigg.metabolite: pap - chebi: CHEBI:58343 - kegg.compound: C00054 - metanetx.chemical: MNXM45 @@ -3103,6 +3374,7 @@ - formula: C10H11N5O10P2 - charge: -4 - annotation: !!omap + - bigg.metabolite: pap - chebi: CHEBI:58343 - kegg.compound: C00054 - metanetx.chemical: MNXM45 @@ -3114,6 +3386,7 @@ - formula: C10H11N5O10P2 - charge: -4 - annotation: !!omap + - bigg.metabolite: pap - chebi: CHEBI:58343 - kegg.compound: C00054 - metanetx.chemical: MNXM45 @@ -3125,6 +3398,7 @@ - formula: C14H14N5O11P - charge: -4 - annotation: !!omap + - bigg.metabolite: dcamp - chebi: CHEBI:57567 - kegg.compound: C03794 - metanetx.chemical: MNXM565 @@ -3136,6 +3410,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 - metanetx.chemical: MNXM7 @@ -3147,6 +3422,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 - metanetx.chemical: MNXM7 @@ -3158,6 +3434,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 - metanetx.chemical: MNXM7 @@ -3169,6 +3446,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 - metanetx.chemical: MNXM7 @@ -3180,6 +3458,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 - metanetx.chemical: MNXM7 @@ -3191,6 +3470,7 @@ - formula: C15H21N5O14P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: adprib - chebi: CHEBI:57967 - kegg.compound: C00301 - metanetx.chemical: MNXM48596 @@ -3202,6 +3482,7 @@ - formula: C9H13N4O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: aicar - chebi: CHEBI:58475 - kegg.compound: C04677 - metanetx.chemical: MNXM365 @@ -3210,9 +3491,10 @@ - id: s_0404 - name: Ala-tRNA(Ala) - compartment: c - - formula: C3H6NOR - - charge: 0 + - formula: C3H7NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: alatrna - chebi: CHEBI:17732 - kegg.compound: C00886 - metanetx.chemical: MNXM89815 @@ -3224,6 +3506,7 @@ - formula: C4H7N4O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: alltt - chebi: CHEBI:17536 - kegg.compound: C00499 - metanetx.chemical: MNXM584 @@ -3235,6 +3518,7 @@ - formula: C4H7N4O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: alltt - chebi: CHEBI:17536 - kegg.compound: C00499 - metanetx.chemical: MNXM584 @@ -3246,6 +3530,7 @@ - formula: C4H6N4O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: alltn - chebi: CHEBI:15676 - kegg.compound: C01551 - metanetx.chemical: MNXM612 @@ -3257,6 +3542,7 @@ - formula: C4H6N4O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: alltn - chebi: CHEBI:15676 - kegg.compound: C01551 - metanetx.chemical: MNXM612 @@ -3268,6 +3554,7 @@ - formula: C12H21O14P - charge: -2 - annotation: !!omap + - bigg.metabolite: tre6p - chebi: CHEBI:58429 - kegg.compound: C00689 - metanetx.chemical: MNXM448 @@ -3279,6 +3566,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: gal1p - chebi: CHEBI:58336 - kegg.compound: C00446 - metanetx.chemical: MNXM336 @@ -3290,6 +3578,7 @@ - formula: C6H13NO8P - charge: -1 - annotation: !!omap + - bigg.metabolite: gam1p - chebi: CHEBI:58516 - kegg.compound: C06156 - metanetx.chemical: MNXM969 @@ -3298,29 +3587,31 @@ - id: s_0412 - name: alpha-D-glucosamine 6-phosphate - compartment: c - - formula: C6H14NO8P - - charge: 0 + - formula: C6H13NO8P + - charge: -1 - annotation: !!omap + - bigg.metabolite: gam6p - chebi: CHEBI:15873 - kegg.compound: C00352 - - metanetx.chemical: MNXM162238 + - metanetx.chemical: MNXM370 - sbo: SBO:0000247 - !!omap - id: s_0413 - name: alpha-D-glucosamine 6-phosphate - compartment: e - - formula: C6H14NO8P - - charge: 0 + - formula: C6H13NO8P + - charge: -1 - annotation: !!omap + - bigg.metabolite: gam6p - chebi: CHEBI:15873 - kegg.compound: C00352 - - metanetx.chemical: MNXM162238 + - metanetx.chemical: MNXM370 - sbo: SBO:0000247 - !!omap - id: s_0414 - name: alpha-D-mannosyl-beta-D-mannosyldiacetylchitobiosyldiphosphodolichol - compartment: g - - formula: C38H68N2O27P2 + - formula: C48H84N2O27P2 - charge: 0 - annotation: !!omap - chebi: CHEBI:28067 @@ -3334,6 +3625,7 @@ - formula: C5H9O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: r1p - chebi: CHEBI:57720 - kegg.compound: C00620 - metanetx.chemical: MNXM295 @@ -3345,6 +3637,7 @@ - formula: C5H9O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: r1p - chebi: CHEBI:57720 - kegg.compound: C00620 - metanetx.chemical: MNXM295 @@ -3356,6 +3649,7 @@ - formula: C2H6NO - charge: 1 - annotation: !!omap + - bigg.metabolite: aacald - chebi: CHEBI:58213 - kegg.compound: C06735 - metanetx.chemical: MNXM2212 @@ -3367,6 +3661,7 @@ - formula: C3H8NO - charge: 1 - annotation: !!omap + - bigg.metabolite: aact - chebi: CHEBI:58320 - kegg.compound: C01888 - metanetx.chemical: MNXM1106 @@ -3378,6 +3673,7 @@ - formula: H4N - charge: 1 - annotation: !!omap + - bigg.metabolite: nh4 - chebi: CHEBI:28938 - kegg.compound: C01342 - metanetx.chemical: MNXM15 @@ -3389,6 +3685,7 @@ - formula: H4N - charge: 1 - annotation: !!omap + - bigg.metabolite: nh4 - chebi: CHEBI:28938 - kegg.compound: C01342 - metanetx.chemical: MNXM15 @@ -3400,6 +3697,7 @@ - formula: H4N - charge: 1 - annotation: !!omap + - bigg.metabolite: nh4 - chebi: CHEBI:28938 - kegg.compound: C01342 - metanetx.chemical: MNXM15 @@ -3411,6 +3709,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: amp - chebi: CHEBI:456215 - kegg.compound: C00020 - metanetx.chemical: MNXM14 @@ -3422,6 +3721,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: amp - chebi: CHEBI:456215 - kegg.compound: C00020 - metanetx.chemical: MNXM14 @@ -3433,6 +3733,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: amp - chebi: CHEBI:456215 - kegg.compound: C00020 - metanetx.chemical: MNXM14 @@ -3444,6 +3745,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: amp - chebi: CHEBI:456215 - kegg.compound: C00020 - metanetx.chemical: MNXM14 @@ -3455,6 +3757,7 @@ - formula: C7H6NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: anth - chebi: CHEBI:16567 - kegg.compound: C00108 - metanetx.chemical: MNXM188 @@ -3463,9 +3766,10 @@ - id: s_0428 - name: Arg-tRNA(Arg) - compartment: c - - formula: C6H14N4OR - - charge: 0 + - formula: C6H15N4OR + - charge: 2 - annotation: !!omap + - bigg.metabolite: argtrna - chebi: CHEBI:18366 - kegg.compound: C02163 - metanetx.chemical: MNXM89870 @@ -3474,9 +3778,10 @@ - id: s_0429 - name: Arg-tRNA(Arg) - compartment: m - - formula: C6H14N4OR - - charge: 0 + - formula: C6H15N4OR + - charge: 2 - annotation: !!omap + - bigg.metabolite: argtrna - chebi: CHEBI:18366 - kegg.compound: C02163 - metanetx.chemical: MNXM89870 @@ -3485,9 +3790,10 @@ - id: s_0430 - name: Asn-tRNA(Asn) - compartment: c - - formula: C4H7N2O2R - - charge: 0 + - formula: C4H8N2O2R + - charge: 1 - annotation: !!omap + - bigg.metabolite: asntrna - chebi: CHEBI:29265 - kegg.compound: C03402 - metanetx.chemical: MNXM89761 @@ -3496,9 +3802,10 @@ - id: s_0431 - name: Asn-tRNA(Asn) - compartment: m - - formula: C4H7N2O2R - - charge: 0 + - formula: C4H8N2O2R + - charge: 1 - annotation: !!omap + - bigg.metabolite: asntrna - chebi: CHEBI:29265 - kegg.compound: C03402 - metanetx.chemical: MNXM89761 @@ -3507,9 +3814,10 @@ - id: s_0432 - name: Asp-tRNA(Asp) - compartment: c - - formula: C4H5NO3R + - formula: C4H6NO3R - charge: 0 - annotation: !!omap + - bigg.metabolite: asptrna - chebi: CHEBI:29158 - kegg.compound: C02984 - metanetx.chemical: MNXM164570 @@ -3518,9 +3826,10 @@ - id: s_0433 - name: Asp-tRNA(Asp) - compartment: m - - formula: C4H5NO3R + - formula: C4H6NO3R - charge: 0 - annotation: !!omap + - bigg.metabolite: asptrna - chebi: CHEBI:29158 - kegg.compound: C02984 - metanetx.chemical: MNXM164570 @@ -3532,6 +3841,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -3543,6 +3853,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -3554,6 +3865,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -3565,6 +3877,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -3576,6 +3889,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -3587,6 +3901,7 @@ - formula: C3H7NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_B - chebi: CHEBI:16958 - kegg.compound: C00099 - metanetx.chemical: MNXM144 @@ -3598,6 +3913,7 @@ - formula: C6H10O12P2 - charge: -4 - annotation: !!omap + - bigg.metabolite: f26bp - chebi: CHEBI:58579 - kegg.compound: C00665 - metanetx.chemical: MNXM651 @@ -3606,9 +3922,10 @@ - id: s_0443 - name: beta-D-mannosyldiacetylchitobiosyldiphosphodolichol - compartment: c - - formula: C32H58N2O22P2 - - charge: 0 + - formula: C42H72N2O22P2 + - charge: -2 - annotation: !!omap + - bigg.metabolite: mpdol - chebi: CHEBI:18396 - kegg.compound: C05860 - metanetx.chemical: MNXM1078 @@ -3617,9 +3934,10 @@ - id: s_0444 - name: beta-D-mannosyldiacetylchitobiosyldiphosphodolichol - compartment: g - - formula: C32H58N2O22P2 - - charge: 0 + - formula: C42H72N2O22P2 + - charge: -2 - annotation: !!omap + - bigg.metabolite: mpdol - chebi: CHEBI:18396 - kegg.compound: C05860 - metanetx.chemical: MNXM1078 @@ -3631,6 +3949,7 @@ - formula: CHO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: hco3 - chebi: CHEBI:17544 - kegg.compound: C00288 - metanetx.chemical: MNXM60 @@ -3642,6 +3961,7 @@ - formula: CHO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: hco3 - chebi: CHEBI:17544 - kegg.compound: C00288 - metanetx.chemical: MNXM60 @@ -3653,6 +3973,7 @@ - formula: CHO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: hco3 - chebi: CHEBI:17544 - kegg.compound: C00288 - metanetx.chemical: MNXM60 @@ -3664,6 +3985,7 @@ - formula: CHO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: hco3 - chebi: CHEBI:17544 - kegg.compound: C00288 - metanetx.chemical: MNXM60 @@ -3674,6 +3996,7 @@ - compartment: c - charge: 0 - annotation: !!omap + - bigg.metabolite: biomass - sbo: SBO:0000649 - !!omap - id: s_0451 @@ -3682,6 +4005,7 @@ - formula: C10H15N2O3S - charge: -1 - annotation: !!omap + - bigg.metabolite: btn - chebi: CHEBI:57586 - kegg.compound: C00120 - metanetx.chemical: MNXM304 @@ -3693,6 +4017,7 @@ - formula: C10H15N2O3S - charge: -1 - annotation: !!omap + - bigg.metabolite: btn - chebi: CHEBI:57586 - kegg.compound: C00120 - metanetx.chemical: MNXM304 @@ -3704,6 +4029,7 @@ - formula: C20H27N7O9PS - charge: -1 - annotation: !!omap + - bigg.metabolite: btamp - chebi: CHEBI:62414 - kegg.compound: C05921 - metanetx.chemical: MNXM2351 @@ -3715,6 +4041,7 @@ - formula: C7H5O6 - charge: -3 - annotation: !!omap + - bigg.metabolite: b124tc - chebi: CHEBI:58174 - kegg.compound: C04002 - metanetx.chemical: MNXM920 @@ -3726,6 +4053,7 @@ - formula: CH2NO5P - charge: -2 - annotation: !!omap + - bigg.metabolite: cbp - chebi: CHEBI:58228 - kegg.compound: C00169 - metanetx.chemical: MNXM138 @@ -3737,6 +4065,7 @@ - formula: CO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: co2 - chebi: CHEBI:16526 - kegg.compound: C00011 - metanetx.chemical: MNXM13 @@ -3748,6 +4077,7 @@ - formula: CO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: co2 - chebi: CHEBI:16526 - kegg.compound: C00011 - metanetx.chemical: MNXM13 @@ -3759,6 +4089,7 @@ - formula: CO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: co2 - chebi: CHEBI:16526 - kegg.compound: C00011 - metanetx.chemical: MNXM13 @@ -3770,6 +4101,7 @@ - formula: CO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: co2 - chebi: CHEBI:16526 - kegg.compound: C00011 - metanetx.chemical: MNXM13 @@ -3781,6 +4113,7 @@ - formula: CO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: co2 - chebi: CHEBI:16526 - kegg.compound: C00011 - metanetx.chemical: MNXM13 @@ -3792,6 +4125,7 @@ - formula: CO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: co2 - chebi: CHEBI:16526 - kegg.compound: C00011 - metanetx.chemical: MNXM13 @@ -3803,6 +4137,7 @@ - formula: C3H3O3SR - charge: 0 - annotation: !!omap + - bigg.metabolite: malACP - chebi: CHEBI:17330 - kegg.compound: C01209 - metanetx.chemical: MNXM184 @@ -3814,6 +4149,7 @@ - formula: C9H12N3O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: cdp - chebi: CHEBI:58069 - kegg.compound: C00112 - metanetx.chemical: MNXM220 @@ -3825,6 +4161,7 @@ - formula: C9H12N3O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: cdp - chebi: CHEBI:58069 - kegg.compound: C00112 - metanetx.chemical: MNXM220 @@ -3833,9 +4170,10 @@ - id: s_0469 - name: CDP-choline - compartment: c - - formula: C14H26N4O11P2 - - charge: 0 + - formula: C14H25N4O11P2 + - charge: -1 - annotation: !!omap + - bigg.metabolite: cdpchol - chebi: CHEBI:16436 - kegg.compound: C00307 - metanetx.chemical: MNXM283 @@ -3847,6 +4185,7 @@ - formula: C11H19N4O11P2 - charge: -1 - annotation: !!omap + - bigg.metabolite: cdpea - chebi: CHEBI:57876 - kegg.compound: C00570 - metanetx.chemical: MNXM449 @@ -3858,6 +4197,7 @@ - formula: C42H85NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer1_24 - chebi: CHEBI:52961 - metanetx.chemical: MNXM64020 - sbo: SBO:0000247 @@ -3868,6 +4208,7 @@ - formula: C42H85NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer1_24 - chebi: CHEBI:52961 - metanetx.chemical: MNXM64020 - sbo: SBO:0000247 @@ -3878,6 +4219,7 @@ - formula: C42H85NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer1_24 - chebi: CHEBI:52961 - metanetx.chemical: MNXM64020 - sbo: SBO:0000247 @@ -3888,6 +4230,7 @@ - formula: C44H89NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer1_26 - chebi: CHEBI:52962 - metanetx.chemical: MNXM63798 - sbo: SBO:0000247 @@ -3898,6 +4241,7 @@ - formula: C44H89NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer1_26 - chebi: CHEBI:52962 - metanetx.chemical: MNXM63798 - sbo: SBO:0000247 @@ -3908,6 +4252,7 @@ - formula: C44H89NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer1_26 - chebi: CHEBI:52962 - metanetx.chemical: MNXM63798 - sbo: SBO:0000247 @@ -3918,6 +4263,7 @@ - formula: C42H85NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer2_24 - chebi: CHEBI:52979 - metanetx.chemical: MNXM64019 - sbo: SBO:0000247 @@ -3928,6 +4274,7 @@ - formula: C42H85NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer2_24 - chebi: CHEBI:52979 - metanetx.chemical: MNXM64019 - sbo: SBO:0000247 @@ -3938,6 +4285,7 @@ - formula: C42H85NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer2_24 - chebi: CHEBI:52979 - metanetx.chemical: MNXM64019 - sbo: SBO:0000247 @@ -3948,6 +4296,7 @@ - formula: C44H89NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer2_26 - chebi: CHEBI:52980 - metanetx.chemical: MNXM63797 - sbo: SBO:0000247 @@ -3958,6 +4307,7 @@ - formula: C44H89NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer2_26 - chebi: CHEBI:52980 - metanetx.chemical: MNXM63797 - sbo: SBO:0000247 @@ -3968,6 +4318,7 @@ - formula: C44H89NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer2_26 - chebi: CHEBI:52980 - metanetx.chemical: MNXM63797 - sbo: SBO:0000247 @@ -4038,6 +4389,7 @@ - formula: C42H85NO5 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer3_24 - chebi: CHEBI:52373 - metanetx.chemical: MNXM63174 - sbo: SBO:0000247 @@ -4048,6 +4400,7 @@ - formula: C42H85NO5 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer3_24 - chebi: CHEBI:52373 - metanetx.chemical: MNXM63174 - sbo: SBO:0000247 @@ -4058,6 +4411,7 @@ - formula: C42H85NO5 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer3_24 - chebi: CHEBI:52373 - metanetx.chemical: MNXM63174 - sbo: SBO:0000247 @@ -4068,6 +4422,7 @@ - formula: C44H89NO5 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer3_26 - chebi: CHEBI:52374 - metanetx.chemical: MNXM63157 - sbo: SBO:0000247 @@ -4078,6 +4433,7 @@ - formula: C44H89NO5 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer3_26 - chebi: CHEBI:52374 - metanetx.chemical: MNXM63157 - sbo: SBO:0000247 @@ -4088,6 +4444,7 @@ - formula: C44H89NO5 - charge: 0 - annotation: !!omap + - bigg.metabolite: cer3_26 - chebi: CHEBI:52374 - metanetx.chemical: MNXM63157 - sbo: SBO:0000247 @@ -4158,6 +4515,7 @@ - formula: C26H51O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hexc - chebi: CHEBI:31013 - metanetx.chemical: MNXM46158 - sbo: SBO:0000247 @@ -4168,6 +4526,7 @@ - formula: C8H13NO5 - charge: 0 - annotation: !!omap + - bigg.metabolite: chtn - chebi: CHEBI:17029 - kegg.compound: C00461 - metanetx.chemical: MNXM1271 @@ -4176,9 +4535,10 @@ - id: s_0510 - name: chitosan - compartment: ce - - formula: C6H12NO4 + - formula: C6H11NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: chitos - chebi: CHEBI:16261 - kegg.compound: C00734 - metanetx.chemical: MNXM2106 @@ -4190,6 +4550,7 @@ - formula: C5H14NO - charge: 1 - annotation: !!omap + - bigg.metabolite: chol - chebi: CHEBI:15354 - kegg.compound: C00114 - metanetx.chemical: MNXM90 @@ -4201,6 +4562,7 @@ - formula: C5H14NO - charge: 1 - annotation: !!omap + - bigg.metabolite: chol - chebi: CHEBI:15354 - kegg.compound: C00114 - metanetx.chemical: MNXM90 @@ -4212,6 +4574,7 @@ - formula: C5H14NO - charge: 1 - annotation: !!omap + - bigg.metabolite: chol - chebi: CHEBI:15354 - kegg.compound: C00114 - metanetx.chemical: MNXM90 @@ -4223,6 +4586,7 @@ - formula: C5H13NO4P - charge: -1 - annotation: !!omap + - bigg.metabolite: cholp - chebi: CHEBI:295975 - kegg.compound: C00588 - metanetx.chemical: MNXM229 @@ -4234,6 +4598,7 @@ - formula: C10H8O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: chor - chebi: CHEBI:29748 - kegg.compound: C00251 - metanetx.chemical: MNXM337 @@ -4245,6 +4610,7 @@ - formula: C6H3O6 - charge: -3 - annotation: !!omap + - bigg.metabolite: acon_C - chebi: CHEBI:16383 - kegg.compound: C00417 - metanetx.chemical: MNXM813 @@ -4256,6 +4622,7 @@ - formula: C6H3O6 - charge: -3 - annotation: !!omap + - bigg.metabolite: acon_C - chebi: CHEBI:16383 - kegg.compound: C00417 - metanetx.chemical: MNXM813 @@ -4267,6 +4634,7 @@ - formula: C6H5O7 - charge: -3 - annotation: !!omap + - bigg.metabolite: cit - chebi: CHEBI:16947 - kegg.compound: C00158 - metanetx.chemical: MNXM131 @@ -4278,6 +4646,7 @@ - formula: C6H5O7 - charge: -3 - annotation: !!omap + - bigg.metabolite: cit - chebi: CHEBI:16947 - kegg.compound: C00158 - metanetx.chemical: MNXM131 @@ -4289,6 +4658,7 @@ - formula: C6H5O7 - charge: -3 - annotation: !!omap + - bigg.metabolite: cit - chebi: CHEBI:16947 - kegg.compound: C00158 - metanetx.chemical: MNXM131 @@ -4300,6 +4670,7 @@ - formula: C6H5O7 - charge: -3 - annotation: !!omap + - bigg.metabolite: cit - chebi: CHEBI:16947 - kegg.compound: C00158 - metanetx.chemical: MNXM131 @@ -4311,6 +4682,7 @@ - formula: C9H12N3O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: cmp - chebi: CHEBI:60377 - kegg.compound: C00055 - metanetx.chemical: MNXM31 @@ -4322,6 +4694,7 @@ - formula: C9H12N3O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: cmp - chebi: CHEBI:60377 - kegg.compound: C00055 - metanetx.chemical: MNXM31 @@ -4333,6 +4706,7 @@ - formula: C21H32N7O16P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: coa - chebi: CHEBI:57287 - kegg.compound: C00010 - metanetx.chemical: MNXM12 @@ -4344,6 +4718,7 @@ - formula: C21H32N7O16P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: coa - chebi: CHEBI:57287 - kegg.compound: C00010 - metanetx.chemical: MNXM12 @@ -4355,6 +4730,7 @@ - formula: C21H32N7O16P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: coa - chebi: CHEBI:57287 - kegg.compound: C00010 - metanetx.chemical: MNXM12 @@ -4366,6 +4742,7 @@ - formula: C21H32N7O16P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: coa - chebi: CHEBI:57287 - kegg.compound: C00010 - metanetx.chemical: MNXM12 @@ -4377,6 +4754,7 @@ - formula: C21H32N7O16P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: coa - chebi: CHEBI:57287 - kegg.compound: C00010 - metanetx.chemical: MNXM12 @@ -4388,6 +4766,7 @@ - formula: C21H32N7O16P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: coa - chebi: CHEBI:57287 - kegg.compound: C00010 - metanetx.chemical: MNXM12 @@ -4399,6 +4778,7 @@ - formula: C36H40N4O8 - charge: -4 - annotation: !!omap + - bigg.metabolite: cpppg3 - chebi: CHEBI:57309 - kegg.compound: C03263 - metanetx.chemical: MNXM410 @@ -4410,6 +4790,7 @@ - formula: C9H12N3O14P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: ctp - chebi: CHEBI:37563 - kegg.compound: C00063 - metanetx.chemical: MNXM63 @@ -4421,6 +4802,7 @@ - formula: C9H12N3O14P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: ctp - chebi: CHEBI:37563 - kegg.compound: C00063 - metanetx.chemical: MNXM63 @@ -4429,9 +4811,10 @@ - id: s_0542 - name: Cys-tRNA(Cys) - compartment: c - - formula: C3H6NOSR - - charge: 0 + - formula: C3H7NOSR + - charge: 1 - annotation: !!omap + - bigg.metabolite: cystrna - chebi: CHEBI:29152 - kegg.compound: C03125 - metanetx.chemical: MNXM155005 @@ -4443,6 +4826,7 @@ - formula: C9H13N3O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: cytd - chebi: CHEBI:17562 - kegg.compound: C00475 - metanetx.chemical: MNXM338 @@ -4454,6 +4838,7 @@ - formula: C9H13N3O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: cytd - chebi: CHEBI:17562 - kegg.compound: C00475 - metanetx.chemical: MNXM338 @@ -4465,6 +4850,7 @@ - formula: C4H5N3O - charge: 0 - annotation: !!omap + - bigg.metabolite: csn - chebi: CHEBI:16040 - kegg.compound: C00380 - metanetx.chemical: MNXM761 @@ -4476,6 +4862,7 @@ - formula: C4H5N3O - charge: 0 - annotation: !!omap + - bigg.metabolite: csn - chebi: CHEBI:16040 - kegg.compound: C00380 - metanetx.chemical: MNXM761 @@ -4487,6 +4874,7 @@ - formula: C5H8O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: Dara14lac - chebi: CHEBI:16292 - kegg.compound: C00652 - metanetx.chemical: MNXM778 @@ -4498,6 +4886,7 @@ - formula: C5H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: arab__D - chebi: CHEBI:17108 - kegg.compound: C00216 - metanetx.chemical: MNXM40571 @@ -4509,6 +4898,7 @@ - formula: C5H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: arab__D - chebi: CHEBI:17108 - kegg.compound: C00216 - metanetx.chemical: MNXM40571 @@ -4520,6 +4910,7 @@ - formula: C6H9N2O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: eig3p - chebi: CHEBI:58278 - kegg.compound: C04666 - metanetx.chemical: MNXM1422 @@ -4531,6 +4922,7 @@ - formula: C4H7O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: e4p - chebi: CHEBI:16897 - kegg.compound: C00279 - metanetx.chemical: MNXM258 @@ -4542,6 +4934,7 @@ - formula: C4H7O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: e4p - chebi: CHEBI:16897 - kegg.compound: C00279 - metanetx.chemical: MNXM258 @@ -4553,6 +4946,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: fru - chebi: CHEBI:15824 - kegg.compound: C00095 - metanetx.chemical: MNXM175 @@ -4564,6 +4958,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: fru - chebi: CHEBI:15824 - kegg.compound: C00095 - metanetx.chemical: MNXM175 @@ -4572,23 +4967,25 @@ - id: s_0555 - name: D-fructose 1,6-bisphosphate - compartment: c - - formula: C6H14O12P2 - - charge: 0 + - formula: C6H10O12P2 + - charge: -4 - annotation: !!omap + - bigg.metabolite: fdp - chebi: CHEBI:16905 - kegg.compound: C00354 - - metanetx.chemical: MNXM500 + - metanetx.chemical: MNXM417 - sbo: SBO:0000247 - !!omap - id: s_0556 - name: D-fructose 1-phosphate - compartment: c - - formula: C6H13O9P - - charge: 0 + - formula: C6H11O9P + - charge: -2 - annotation: !!omap + - bigg.metabolite: f1p - chebi: CHEBI:18105 - kegg.compound: C01094 - - metanetx.chemical: MNXM1553 + - metanetx.chemical: MNXM145568 - sbo: SBO:0000247 - !!omap - id: s_0557 @@ -4597,9 +4994,10 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: f6p - chebi: CHEBI:57579 - kegg.compound: C00085 - - metanetx.chemical: MNXM89629 + - metanetx.chemical: MNXM162235 - sbo: SBO:0000247 - !!omap - id: s_0558 @@ -4608,6 +5006,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: gal - chebi: CHEBI:12936 - kegg.compound: C00124 - metanetx.chemical: MNXM390 @@ -4619,6 +5018,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: gal - chebi: CHEBI:12936 - kegg.compound: C00124 - metanetx.chemical: MNXM390 @@ -4630,6 +5030,7 @@ - formula: C6H9O7 - charge: -1 - annotation: !!omap + - bigg.metabolite: galur - chebi: CHEBI:12952 - kegg.compound: C00333 - metanetx.chemical: MNXM693 @@ -4641,6 +5042,7 @@ - formula: C6H14O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: sbt__D - chebi: CHEBI:17924 - kegg.compound: C00794 - metanetx.chemical: MNXM469 @@ -4652,6 +5054,7 @@ - formula: C6H14O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: sbt__D - chebi: CHEBI:17924 - kegg.compound: C00794 - metanetx.chemical: MNXM469 @@ -4663,6 +5066,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: glc__D - chebi: CHEBI:4167 - kegg.compound: C00031 - metanetx.chemical: MNXM41 @@ -4674,6 +5078,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: glc__D - chebi: CHEBI:4167 - kegg.compound: C00031 - metanetx.chemical: MNXM41 @@ -4685,6 +5090,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: glc__D - chebi: CHEBI:4167 - kegg.compound: C00031 - metanetx.chemical: MNXM41 @@ -4696,6 +5102,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: g1p - chebi: CHEBI:57629 - kegg.compound: C00103 - metanetx.chemical: MNXM89588 @@ -4704,9 +5111,10 @@ - id: s_0568 - name: D-glucose 6-phosphate - compartment: c - - formula: C6H13O9P - - charge: 0 + - formula: C6H11O9P + - charge: -2 - annotation: !!omap + - bigg.metabolite: g6p - chebi: CHEBI:14314 - kegg.compound: C00092 - metanetx.chemical: MNXM160 @@ -4718,6 +5126,7 @@ - formula: C3H6O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: glyald - chebi: CHEBI:17378 - kegg.compound: C00577 - metanetx.chemical: MNXM435 @@ -4729,6 +5138,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: man - chebi: CHEBI:16024 - kegg.compound: C00159 - metanetx.chemical: MNXM182 @@ -4740,6 +5150,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: man - chebi: CHEBI:16024 - kegg.compound: C00159 - metanetx.chemical: MNXM182 @@ -4748,9 +5159,10 @@ - id: s_0573 - name: D-mannose 1-phosphate - compartment: c - - formula: C6H13O9P - - charge: 0 + - formula: C6H11O9P + - charge: -2 - annotation: !!omap + - bigg.metabolite: man1p - chebi: CHEBI:35374 - kegg.compound: C00636 - metanetx.chemical: MNXM721 @@ -4759,9 +5171,10 @@ - id: s_0574 - name: D-mannose 6-phosphate - compartment: c - - formula: C6H13O9P - - charge: 0 + - formula: C6H11O9P + - charge: -2 - annotation: !!omap + - bigg.metabolite: man6p - chebi: CHEBI:17369 - kegg.compound: C00275 - metanetx.chemical: MNXM427 @@ -4773,6 +5186,7 @@ - formula: C5H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: rib__D - chebi: CHEBI:16988 - kegg.compound: C00121 - metanetx.chemical: MNXM242 @@ -4784,6 +5198,7 @@ - formula: C5H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: rib__D - chebi: CHEBI:16988 - kegg.compound: C00121 - metanetx.chemical: MNXM242 @@ -4795,6 +5210,7 @@ - formula: C5H9O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: ru5p__D - chebi: CHEBI:58121 - kegg.compound: C00199 - metanetx.chemical: MNXM145 @@ -4806,6 +5222,7 @@ - formula: C5H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: xyl__D - chebi: CHEBI:15936 - kegg.compound: C00181 - metanetx.chemical: MNXM90941 @@ -4817,6 +5234,7 @@ - formula: C5H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: xyl__D - chebi: CHEBI:15936 - kegg.compound: C00181 - metanetx.chemical: MNXM90941 @@ -4828,6 +5246,7 @@ - formula: C5H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: xylu__D - chebi: CHEBI:17140 - kegg.compound: C00310 - metanetx.chemical: MNXM597 @@ -4839,6 +5258,7 @@ - formula: C5H9O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: xu5p__D - chebi: CHEBI:57737 - kegg.compound: C00231 - metanetx.chemical: MNXM186 @@ -4850,6 +5270,7 @@ - formula: C10H12N5O9P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: dadp - chebi: CHEBI:57667 - kegg.compound: C00206 - metanetx.chemical: MNXM374 @@ -4861,6 +5282,7 @@ - formula: C10H12N5O9P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: dadp - chebi: CHEBI:57667 - kegg.compound: C00206 - metanetx.chemical: MNXM374 @@ -4872,6 +5294,7 @@ - formula: C10H12N5O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: damp - chebi: CHEBI:58245 - kegg.compound: C00360 - metanetx.chemical: MNXM432 @@ -4883,6 +5306,7 @@ - formula: C10H12N5O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: damp - chebi: CHEBI:58245 - kegg.compound: C00360 - metanetx.chemical: MNXM432 @@ -4894,6 +5318,7 @@ - formula: C10H12N5O12P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: datp - chebi: CHEBI:61404 - kegg.compound: C00131 - metanetx.chemical: MNXM286 @@ -4905,6 +5330,7 @@ - formula: C9H12N3O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: dcdp - chebi: CHEBI:58593 - kegg.compound: C00705 - metanetx.chemical: MNXM411 @@ -4916,6 +5342,7 @@ - formula: C9H12N3O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: dcdp - chebi: CHEBI:58593 - kegg.compound: C00705 - metanetx.chemical: MNXM411 @@ -4927,6 +5354,7 @@ - formula: C9H12N3O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: dcmp - chebi: CHEBI:57566 - kegg.compound: C00239 - metanetx.chemical: MNXM266 @@ -4935,9 +5363,10 @@ - id: s_0590 - name: dCTP - compartment: c - - formula: C9H13N3O13P3 - - charge: -3 + - formula: C9H12N3O13P3 + - charge: -4 - annotation: !!omap + - bigg.metabolite: dctp - chebi: CHEBI:57724 - kegg.compound: C00458 - metanetx.chemical: MNXM360 @@ -4946,9 +5375,10 @@ - id: s_0591 - name: deamido-NAD(+) - compartment: c - - formula: C21H27N6O15P2 - - charge: 1 + - formula: C21H24N6O15P2 + - charge: -2 - annotation: !!omap + - bigg.metabolite: dnad - chebi: CHEBI:18304 - kegg.compound: C00857 - metanetx.chemical: MNXM309 @@ -4957,9 +5387,10 @@ - id: s_0593 - name: deamido-NAD(+) - compartment: n - - formula: C21H27N6O15P2 - - charge: 1 + - formula: C21H24N6O15P2 + - charge: -2 - annotation: !!omap + - bigg.metabolite: dnad - chebi: CHEBI:18304 - kegg.compound: C00857 - metanetx.chemical: MNXM309 @@ -4971,6 +5402,7 @@ - formula: C10H19O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: dca - chebi: CHEBI:27689 - kegg.compound: C01571 - metanetx.chemical: MNXM1043 @@ -4982,6 +5414,7 @@ - formula: C10H19O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: dca - chebi: CHEBI:27689 - kegg.compound: C01571 - metanetx.chemical: MNXM1043 @@ -4993,6 +5426,7 @@ - formula: C10H19O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: dca - chebi: CHEBI:27689 - kegg.compound: C01571 - metanetx.chemical: MNXM1043 @@ -5004,6 +5438,7 @@ - formula: C31H50N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: dccoa - chebi: CHEBI:61430 - kegg.compound: C05274 - metanetx.chemical: MNXM486 @@ -5012,9 +5447,10 @@ - id: s_0606 - name: decaprenyl diphosphate - compartment: lp - - formula: C50H84O7P2 - - charge: 0 + - formula: C50H81O7P2 + - charge: -3 - annotation: !!omap + - bigg.metabolite: decdp - chebi: CHEBI:53043 - kegg.compound: C17432 - metanetx.chemical: MNXM1721 @@ -5034,8 +5470,8 @@ - id: s_0608 - name: Delta(6)-trans,Delta(8)-cis-leukotriene B4 - compartment: c - - formula: C20H32O4 - - charge: 0 + - formula: C20H31O4 + - charge: -1 - annotation: !!omap - chebi: CHEBI:53027 - metanetx.chemical: MNXM507621 @@ -5044,8 +5480,8 @@ - id: s_0609 - name: Delta(6)-trans,Delta(8)-cis-leukotriene B4 - compartment: n - - formula: C20H32O4 - - charge: 0 + - formula: C20H31O4 + - charge: -1 - annotation: !!omap - chebi: CHEBI:53027 - metanetx.chemical: MNXM507621 @@ -5057,6 +5493,7 @@ - formula: C9H13N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: dcyt - chebi: CHEBI:15698 - kegg.compound: C00881 - metanetx.chemical: MNXM704 @@ -5068,6 +5505,7 @@ - formula: C9H13N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: dcyt - chebi: CHEBI:15698 - kegg.compound: C00881 - metanetx.chemical: MNXM704 @@ -5079,6 +5517,7 @@ - formula: C10H17N2O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: dtbt - chebi: CHEBI:57861 - kegg.compound: C01909 - metanetx.chemical: MNXM1020 @@ -5090,6 +5529,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: dgdp - chebi: CHEBI:58595 - kegg.compound: C00361 - metanetx.chemical: MNXM436 @@ -5101,6 +5541,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: dgdp - chebi: CHEBI:58595 - kegg.compound: C00361 - metanetx.chemical: MNXM436 @@ -5112,6 +5553,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: dgmp - chebi: CHEBI:57673 - kegg.compound: C00362 - metanetx.chemical: MNXM546 @@ -5123,6 +5565,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: dgmp - chebi: CHEBI:57673 - kegg.compound: C00362 - metanetx.chemical: MNXM546 @@ -5131,9 +5574,10 @@ - id: s_0617 - name: dGTP - compartment: c - - formula: C10H13N5O13P3 - - charge: -3 + - formula: C10H12N5O13P3 + - charge: -4 - annotation: !!omap + - bigg.metabolite: dgtp - chebi: CHEBI:57794 - kegg.compound: C00286 - metanetx.chemical: MNXM344 @@ -5142,9 +5586,10 @@ - id: s_0618 - name: dIDP - compartment: c - - formula: C10H14N4O10P2 - - charge: 0 + - formula: C10H11N4O10P2 + - charge: -3 - annotation: !!omap + - bigg.metabolite: didp - chebi: CHEBI:28823 - kegg.compound: C01344 - metanetx.chemical: MNXM2174 @@ -5155,6 +5600,7 @@ - compartment: er - formula: C3H4O - annotation: !!omap + - bigg.metabolite: dag_hs - chebi: CHEBI:18035 - kegg.compound: C00165 - metanetx.chemical: MNXM59 @@ -5166,6 +5612,7 @@ - formula: C19H19N7O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: dhf - chebi: CHEBI:57451 - kegg.compound: C00415 - metanetx.chemical: MNXM281 @@ -5177,6 +5624,7 @@ - formula: C19H19N7O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: dhf - chebi: CHEBI:57451 - kegg.compound: C00415 - metanetx.chemical: MNXM281 @@ -5188,6 +5636,7 @@ - formula: C8H17NOS2 - charge: 0 - annotation: !!omap + - bigg.metabolite: dhlam - chebi: CHEBI:17694 - kegg.compound: C00579 - metanetx.chemical: MNXM1277 @@ -5196,9 +5645,10 @@ - id: s_0628 - name: dihydrolipoylprotein - compartment: m - - formula: C8H15OS2R + - formula: C8H16NOS2R - charge: 0 - annotation: !!omap + - bigg.metabolite: dhlpro - chebi: CHEBI:16194 - kegg.compound: C02972 - metanetx.chemical: MNXM1663 @@ -5210,6 +5660,7 @@ - formula: C3H5O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: dhap - chebi: CHEBI:57642 - kegg.compound: C00111 - metanetx.chemical: MNXM77 @@ -5221,6 +5672,7 @@ - formula: C3H5O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: dhap - chebi: CHEBI:57642 - kegg.compound: C00111 - metanetx.chemical: MNXM77 @@ -5232,6 +5684,7 @@ - formula: C3H5O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: dhap - chebi: CHEBI:57642 - kegg.compound: C00111 - metanetx.chemical: MNXM77 @@ -5243,6 +5696,7 @@ - formula: HO7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ppi - chebi: CHEBI:33019 - kegg.compound: C00013 - metanetx.chemical: MNXM11 @@ -5254,6 +5708,7 @@ - formula: HO7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ppi - chebi: CHEBI:33019 - kegg.compound: C00013 - metanetx.chemical: MNXM11 @@ -5265,6 +5720,7 @@ - formula: HO7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ppi - chebi: CHEBI:33019 - kegg.compound: C00013 - metanetx.chemical: MNXM11 @@ -5276,6 +5732,7 @@ - formula: HO7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ppi - chebi: CHEBI:33019 - kegg.compound: C00013 - metanetx.chemical: MNXM11 @@ -5287,6 +5744,7 @@ - formula: HO7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ppi - chebi: CHEBI:33019 - kegg.compound: C00013 - metanetx.chemical: MNXM11 @@ -5298,6 +5756,7 @@ - formula: C10H11N4O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: ditp - chebi: CHEBI:61382 - kegg.compound: C01345 - metanetx.chemical: MNXM1325 @@ -5306,8 +5765,8 @@ - id: s_0640 - name: docosaprenyl diphosphate - compartment: lp - - formula: C110H180O7P2 - - charge: 0 + - formula: C110H177O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53031 - metanetx.chemical: MNXM51449 @@ -5316,10 +5775,11 @@ - id: s_0641 - name: dodecaprenyl diphosphate - compartment: lp - - formula: C60H100O7P2 - - charge: 0 + - formula: C60H97O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53041 + - kegg.compound: C05847 - metanetx.chemical: MNXM11433 - sbo: SBO:0000247 - !!omap @@ -5329,6 +5789,7 @@ - formula: C20H36O - charge: 0 - annotation: !!omap + - bigg.metabolite: dolichol - chebi: CHEBI:16091 - kegg.compound: C00381 - metanetx.chemical: MNXM797 @@ -5340,6 +5801,7 @@ - formula: C26H47O9P - charge: 0 - annotation: !!omap + - bigg.metabolite: dolmanp - chebi: CHEBI:15809 - kegg.compound: C03862 - metanetx.chemical: MNXM296 @@ -5351,6 +5813,7 @@ - formula: C20H37O4P - charge: 0 - annotation: !!omap + - bigg.metabolite: dolp - chebi: CHEBI:16214 - kegg.compound: C00110 - metanetx.chemical: MNXM278 @@ -5362,6 +5825,7 @@ - formula: C20H37O4P - charge: 0 - annotation: !!omap + - bigg.metabolite: dolp - chebi: CHEBI:16214 - kegg.compound: C00110 - metanetx.chemical: MNXM278 @@ -5373,6 +5837,7 @@ - formula: C10H13N2O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: dtdp - chebi: CHEBI:58369 - kegg.compound: C00363 - metanetx.chemical: MNXM152 @@ -5381,9 +5846,10 @@ - id: s_0649 - name: dTMP - compartment: c - - formula: C10H15N2O8P - - charge: 0 + - formula: C10H13N2O8P + - charge: -2 - annotation: !!omap + - bigg.metabolite: dtmp - chebi: CHEBI:17013 - kegg.compound: C00364 - metanetx.chemical: MNXM257 @@ -5392,9 +5858,10 @@ - id: s_0650 - name: dTTP - compartment: c - - formula: C10H14N2O14P3 - - charge: -3 + - formula: C10H13N2O14P3 + - charge: -4 - annotation: !!omap + - bigg.metabolite: dttp - chebi: CHEBI:58370 - kegg.compound: C00459 - metanetx.chemical: MNXM394 @@ -5403,9 +5870,10 @@ - id: s_0651 - name: dTTP - compartment: e - - formula: C10H14N2O14P3 - - charge: -3 + - formula: C10H13N2O14P3 + - charge: -4 - annotation: !!omap + - bigg.metabolite: dttp - chebi: CHEBI:58370 - kegg.compound: C00459 - metanetx.chemical: MNXM394 @@ -5417,6 +5885,7 @@ - formula: C9H11N2O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: dudp - chebi: CHEBI:60471 - kegg.compound: C01346 - metanetx.chemical: MNXM572 @@ -5428,6 +5897,7 @@ - formula: C9H11N2O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: dudp - chebi: CHEBI:60471 - kegg.compound: C01346 - metanetx.chemical: MNXM572 @@ -5439,6 +5909,7 @@ - formula: C9H11N2O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: dump - chebi: CHEBI:246422 - kegg.compound: C00365 - metanetx.chemical: MNXM234 @@ -5450,6 +5921,7 @@ - formula: C9H11N2O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: dump - chebi: CHEBI:246422 - kegg.compound: C00365 - metanetx.chemical: MNXM234 @@ -5458,9 +5930,10 @@ - id: s_0656 - name: dUTP - compartment: c - - formula: C9H12N2O14P3 - - charge: -3 + - formula: C9H11N2O14P3 + - charge: -4 - annotation: !!omap + - bigg.metabolite: dutp - chebi: CHEBI:58212 - kegg.compound: C00460 - metanetx.chemical: MNXM452 @@ -5472,6 +5945,7 @@ - formula: C28H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: epist - chebi: CHEBI:23929 - kegg.compound: C15777 - metanetx.chemical: MNXM52365 @@ -5483,6 +5957,7 @@ - formula: C28H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: epist - chebi: CHEBI:23929 - kegg.compound: C15777 - metanetx.chemical: MNXM52365 @@ -5494,6 +5969,7 @@ - formula: C28H42O - charge: 0 - annotation: !!omap + - bigg.metabolite: ergtetrol - chebi: CHEBI:18249 - kegg.compound: C05440 - metanetx.chemical: MNXM1109 @@ -5505,6 +5981,7 @@ - formula: C28H42O - charge: 0 - annotation: !!omap + - bigg.metabolite: ergtetrol - chebi: CHEBI:18249 - kegg.compound: C05440 - metanetx.chemical: MNXM1109 @@ -5516,6 +5993,7 @@ - formula: C28H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: ergtrol - chebi: CHEBI:52972 - kegg.compound: C15780 - metanetx.chemical: MNXM5738 @@ -5527,6 +6005,7 @@ - formula: C28H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: ergst - chebi: CHEBI:16933 - kegg.compound: C01694 - metanetx.chemical: MNXM922 @@ -5538,6 +6017,7 @@ - formula: C28H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: ergst - chebi: CHEBI:16933 - kegg.compound: C01694 - metanetx.chemical: MNXM922 @@ -5549,6 +6029,7 @@ - formula: C28H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: ergst - chebi: CHEBI:16933 - kegg.compound: C01694 - metanetx.chemical: MNXM922 @@ -5560,6 +6041,7 @@ - formula: C28H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: ergst - chebi: CHEBI:16933 - kegg.compound: C01694 - metanetx.chemical: MNXM922 @@ -5571,6 +6053,7 @@ - formula: C28H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: ergst - chebi: CHEBI:16933 - kegg.compound: C01694 - metanetx.chemical: MNXM922 @@ -5582,6 +6065,7 @@ - formula: C34H54O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: ergst3glc - chebi: CHEBI:52973 - metanetx.chemical: MNXM52465 - sbo: SBO:0000247 @@ -5599,9 +6083,10 @@ - id: s_0677 - name: erythro-4-hydroxy-L-glutamic acid - compartment: c - - formula: C5H9NO5 - - charge: 0 + - formula: C5H8NO5 + - charge: -1 - annotation: !!omap + - bigg.metabolite: e4hglu - chebi: CHEBI:21285 - kegg.compound: C05947 - metanetx.chemical: MNXM923 @@ -5610,9 +6095,10 @@ - id: s_0678 - name: erythro-4-hydroxy-L-glutamic acid - compartment: m - - formula: C5H9NO5 - - charge: 0 + - formula: C5H8NO5 + - charge: -1 - annotation: !!omap + - bigg.metabolite: e4hglu - chebi: CHEBI:21285 - kegg.compound: C05947 - metanetx.chemical: MNXM923 @@ -5621,9 +6107,10 @@ - id: s_0679 - name: erythro-4-hydroxy-L-glutamic acid - compartment: p - - formula: C5H9NO5 - - charge: 0 + - formula: C5H8NO5 + - charge: -1 - annotation: !!omap + - bigg.metabolite: e4hglu - chebi: CHEBI:21285 - kegg.compound: C05947 - metanetx.chemical: MNXM923 @@ -5635,6 +6122,7 @@ - formula: C2H6O - charge: 0 - annotation: !!omap + - bigg.metabolite: etoh - chebi: CHEBI:16236 - kegg.compound: C00469 - metanetx.chemical: MNXM303 @@ -5646,6 +6134,7 @@ - formula: C2H6O - charge: 0 - annotation: !!omap + - bigg.metabolite: etoh - chebi: CHEBI:16236 - kegg.compound: C00469 - metanetx.chemical: MNXM303 @@ -5657,6 +6146,7 @@ - formula: C2H6O - charge: 0 - annotation: !!omap + - bigg.metabolite: etoh - chebi: CHEBI:16236 - kegg.compound: C00469 - metanetx.chemical: MNXM303 @@ -5668,6 +6158,7 @@ - formula: C2H8NO - charge: 1 - annotation: !!omap + - bigg.metabolite: etha - chebi: CHEBI:57603 - kegg.compound: C00189 - metanetx.chemical: MNXM218 @@ -5679,6 +6170,7 @@ - formula: C2H8NO - charge: 1 - annotation: !!omap + - bigg.metabolite: etha - chebi: CHEBI:57603 - kegg.compound: C00189 - metanetx.chemical: MNXM218 @@ -5712,6 +6204,7 @@ - formula: C27H30N9O15P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: fad - chebi: CHEBI:57692 - kegg.compound: C00016 - metanetx.chemical: MNXM33 @@ -5723,6 +6216,7 @@ - formula: C27H30N9O15P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: fad - chebi: CHEBI:57692 - kegg.compound: C00016 - metanetx.chemical: MNXM33 @@ -5734,6 +6228,7 @@ - formula: C27H33N9O15P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: fadh2 - chebi: CHEBI:58307 - kegg.compound: C01352 - metanetx.chemical: MNXM38 @@ -5745,6 +6240,7 @@ - formula: C27H33N9O15P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: fadh2 - chebi: CHEBI:58307 - kegg.compound: C01352 - metanetx.chemical: MNXM38 @@ -5756,6 +6252,7 @@ - formula: C15H25O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: frdp - chebi: CHEBI:175763 - kegg.compound: C00448 - metanetx.chemical: MNXM34 @@ -5777,6 +6274,7 @@ - formula: C28H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: fecost - chebi: CHEBI:17038 - kegg.compound: C04525 - metanetx.chemical: MNXM1741 @@ -5788,6 +6286,7 @@ - formula: C28H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: fecost - chebi: CHEBI:17038 - kegg.compound: C04525 - metanetx.chemical: MNXM1741 @@ -5799,6 +6298,7 @@ - formula: C28H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: fecost - chebi: CHEBI:17038 - kegg.compound: C04525 - metanetx.chemical: MNXM1741 @@ -5810,6 +6310,7 @@ - formula: C28H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: fecost - chebi: CHEBI:17038 - kegg.compound: C04525 - metanetx.chemical: MNXM1741 @@ -5821,6 +6322,7 @@ - formula: C42H44FeN8O8S2R4 - charge: 0 - annotation: !!omap + - bigg.metabolite: ficytc - chebi: CHEBI:15991 - kegg.compound: C00125 - metanetx.chemical: MNXM5749 @@ -5829,12 +6331,13 @@ - id: s_0710 - name: ferrocytochrome c - compartment: m - - formula: C42H44FeN8O8S2R4 + - formula: C42H45FeN8O8S2R4 - charge: 0 - annotation: !!omap + - bigg.metabolite: focytc - chebi: CHEBI:16928 - kegg.compound: C00126 - - metanetx.chemical: MNXM5749 + - metanetx.chemical: MNXM746 - sbo: SBO:0000247 - !!omap - id: s_0712 @@ -5843,6 +6346,7 @@ - formula: C34H30FeN4O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: pheme - chebi: CHEBI:60344 - kegg.compound: C00032 - metanetx.chemical: MNXM249 @@ -5854,6 +6358,7 @@ - formula: C6H10NO2SR - charge: 0 - annotation: !!omap + - bigg.metabolite: fmettrna - chebi: CHEBI:17119 - kegg.compound: C03294 - metanetx.chemical: MNXM95381 @@ -5865,6 +6370,7 @@ - formula: C17H18N4O9P - charge: -3 - annotation: !!omap + - bigg.metabolite: fmn - chebi: CHEBI:58210 - kegg.compound: C00061 - metanetx.chemical: MNXM119 @@ -5876,6 +6382,7 @@ - formula: C17H18N4O9P - charge: -3 - annotation: !!omap + - bigg.metabolite: fmn - chebi: CHEBI:58210 - kegg.compound: C00061 - metanetx.chemical: MNXM119 @@ -5887,6 +6394,7 @@ - formula: C17H18N4O9P - charge: -3 - annotation: !!omap + - bigg.metabolite: fmn - chebi: CHEBI:58210 - kegg.compound: C00061 - metanetx.chemical: MNXM119 @@ -5898,6 +6406,7 @@ - formula: C17H21N4O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: fmnh2 - chebi: CHEBI:57618 - kegg.compound: C01847 - metanetx.chemical: MNXM208 @@ -5909,6 +6418,7 @@ - formula: C19H17N7O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: fol - chebi: CHEBI:62501 - kegg.compound: C00504 - metanetx.chemical: MNXM617 @@ -5920,6 +6430,7 @@ - formula: C19H17N7O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: fol - chebi: CHEBI:62501 - kegg.compound: C00504 - metanetx.chemical: MNXM617 @@ -5931,6 +6442,7 @@ - formula: CH2O - charge: 0 - annotation: !!omap + - bigg.metabolite: fald - chebi: CHEBI:16842 - kegg.compound: C00067 - metanetx.chemical: MNXM56 @@ -5942,6 +6454,7 @@ - formula: CHO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: for - chebi: CHEBI:15740 - kegg.compound: C00058 - metanetx.chemical: MNXM39 @@ -5953,6 +6466,7 @@ - formula: CHO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: for - chebi: CHEBI:15740 - kegg.compound: C00058 - metanetx.chemical: MNXM39 @@ -5964,6 +6478,7 @@ - formula: CHO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: for - chebi: CHEBI:15740 - kegg.compound: C00058 - metanetx.chemical: MNXM39 @@ -5975,6 +6490,7 @@ - formula: C4H2O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: fum - chebi: CHEBI:29806 - kegg.compound: C00122 - metanetx.chemical: MNXM93 @@ -5986,6 +6502,7 @@ - formula: C4H2O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: fum - chebi: CHEBI:29806 - kegg.compound: C00122 - metanetx.chemical: MNXM93 @@ -5997,6 +6514,7 @@ - formula: C4H2O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: fum - chebi: CHEBI:29806 - kegg.compound: C00122 - metanetx.chemical: MNXM93 @@ -6008,6 +6526,7 @@ - formula: C4H9NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: 4abut - chebi: CHEBI:16865 - kegg.compound: C00334 - metanetx.chemical: MNXM192 @@ -6019,6 +6538,7 @@ - formula: C4H9NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: 4abut - chebi: CHEBI:16865 - kegg.compound: C00334 - metanetx.chemical: MNXM192 @@ -6030,6 +6550,7 @@ - formula: C4H9NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: 4abut - chebi: CHEBI:16865 - kegg.compound: C00334 - metanetx.chemical: MNXM192 @@ -6041,6 +6562,7 @@ - formula: C10H12N5O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: gdp - chebi: CHEBI:58189 - kegg.compound: C00035 - metanetx.chemical: MNXM30 @@ -6052,6 +6574,7 @@ - formula: C10H12N5O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: gdp - chebi: CHEBI:58189 - kegg.compound: C00035 - metanetx.chemical: MNXM30 @@ -6063,6 +6586,7 @@ - formula: C10H12N5O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: gdp - chebi: CHEBI:58189 - kegg.compound: C00035 - metanetx.chemical: MNXM30 @@ -6074,6 +6598,7 @@ - formula: C10H12N5O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: gdp - chebi: CHEBI:58189 - kegg.compound: C00035 - metanetx.chemical: MNXM30 @@ -6085,6 +6610,7 @@ - formula: C16H23N5O16P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: gdpmann - chebi: CHEBI:57527 - kegg.compound: C00096 - metanetx.chemical: MNXM82 @@ -6096,6 +6622,7 @@ - formula: C16H23N5O16P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: gdpmann - chebi: CHEBI:57527 - kegg.compound: C00096 - metanetx.chemical: MNXM82 @@ -6107,6 +6634,7 @@ - formula: C10H17O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: grdp - chebi: CHEBI:58057 - kegg.compound: C00341 - metanetx.chemical: MNXM100 @@ -6118,6 +6646,7 @@ - formula: C20H33O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ggdp - chebi: CHEBI:58756 - kegg.compound: C00353 - metanetx.chemical: MNXM139 @@ -6126,9 +6655,10 @@ - id: s_0747 - name: Gln-tRNA(Gln) - compartment: c - - formula: C5H9N2O2R - - charge: 0 + - formula: C5H10N2O2R + - charge: 1 - annotation: !!omap + - bigg.metabolite: glntrna - chebi: CHEBI:29166 - kegg.compound: C02282 - metanetx.chemical: MNXM89810 @@ -6137,9 +6667,10 @@ - id: s_0748 - name: Glu-tRNA(Glu) - compartment: c - - formula: C5H7NO3R + - formula: C5H8NO3R - charge: 0 - annotation: !!omap + - bigg.metabolite: glutrna - chebi: CHEBI:29157 - kegg.compound: C02987 - metanetx.chemical: MNXM89752 @@ -6148,9 +6679,10 @@ - id: s_0749 - name: Glu-tRNA(Glu) - compartment: m - - formula: C5H7NO3R + - formula: C5H8NO3R - charge: 0 - annotation: !!omap + - bigg.metabolite: glutrna - chebi: CHEBI:29157 - kegg.compound: C02987 - metanetx.chemical: MNXM89752 @@ -6162,6 +6694,7 @@ - formula: C10H16N3O6S - charge: -1 - annotation: !!omap + - bigg.metabolite: gthrd - chebi: CHEBI:57925 - kegg.compound: C00051 - metanetx.chemical: MNXM57 @@ -6173,6 +6706,7 @@ - formula: C10H16N3O6S - charge: -1 - annotation: !!omap + - bigg.metabolite: gthrd - chebi: CHEBI:57925 - kegg.compound: C00051 - metanetx.chemical: MNXM57 @@ -6184,6 +6718,7 @@ - formula: C10H16N3O6S - charge: -1 - annotation: !!omap + - bigg.metabolite: gthrd - chebi: CHEBI:57925 - kegg.compound: C00051 - metanetx.chemical: MNXM57 @@ -6195,6 +6730,7 @@ - formula: C10H16N3O6S - charge: -1 - annotation: !!omap + - bigg.metabolite: gthrd - chebi: CHEBI:57925 - kegg.compound: C00051 - metanetx.chemical: MNXM57 @@ -6206,6 +6742,7 @@ - formula: C20H30N6O12S2 - charge: -2 - annotation: !!omap + - bigg.metabolite: gthox - chebi: CHEBI:58297 - kegg.compound: C00127 - metanetx.chemical: MNXM151 @@ -6217,6 +6754,7 @@ - formula: C20H30N6O12S2 - charge: -2 - annotation: !!omap + - bigg.metabolite: gthox - chebi: CHEBI:58297 - kegg.compound: C00127 - metanetx.chemical: MNXM151 @@ -6228,6 +6766,7 @@ - formula: C20H30N6O12S2 - charge: -2 - annotation: !!omap + - bigg.metabolite: gthox - chebi: CHEBI:58297 - kegg.compound: C00127 - metanetx.chemical: MNXM151 @@ -6236,9 +6775,10 @@ - id: s_0757 - name: Gly-tRNA(Gly) - compartment: c - - formula: C2H4NOR - - charge: 0 + - formula: C2H5NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: glytrna - chebi: CHEBI:29156 - kegg.compound: C02412 - metanetx.chemical: MNXM89763 @@ -6250,6 +6790,7 @@ - formula: C3H5O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: g3p - chebi: CHEBI:58027 - kegg.compound: C00661 - metanetx.chemical: MNXM74 @@ -6261,6 +6802,7 @@ - formula: C3H8O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: glyc - chebi: CHEBI:17754 - kegg.compound: C00116 - metanetx.chemical: MNXM89612 @@ -6272,6 +6814,7 @@ - formula: C3H8O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: glyc - chebi: CHEBI:17754 - kegg.compound: C00116 - metanetx.chemical: MNXM89612 @@ -6283,6 +6826,7 @@ - formula: C3H7O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: glyc3p - chebi: CHEBI:57597 - kegg.compound: C00093 - metanetx.chemical: MNXM66 @@ -6294,6 +6838,7 @@ - formula: C3H7O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: glyc3p - chebi: CHEBI:57597 - kegg.compound: C00093 - metanetx.chemical: MNXM66 @@ -6305,6 +6850,7 @@ - formula: C3H7O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: glyc3p - chebi: CHEBI:57597 - kegg.compound: C00093 - metanetx.chemical: MNXM66 @@ -6316,6 +6862,7 @@ - formula: C3H6O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: dha - chebi: CHEBI:16016 - kegg.compound: C00184 - metanetx.chemical: MNXM460 @@ -6324,9 +6871,10 @@ - id: s_0773 - name: glycogen - compartment: c - - formula: C6H12O6 + - formula: C6H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: glycogen - chebi: CHEBI:28087 - kegg.compound: C00182 - metanetx.chemical: MNXM55375 @@ -6335,9 +6883,10 @@ - id: s_0774 - name: glycogen - compartment: v - - formula: C6H12O6 + - formula: C6H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: glycogen - chebi: CHEBI:28087 - kegg.compound: C00182 - metanetx.chemical: MNXM55375 @@ -6349,6 +6898,7 @@ - formula: C2H4O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: gcald - chebi: CHEBI:17071 - kegg.compound: C00266 - metanetx.chemical: MNXM349 @@ -6360,6 +6910,7 @@ - formula: C2H4O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: gcald - chebi: CHEBI:17071 - kegg.compound: C00266 - metanetx.chemical: MNXM349 @@ -6371,6 +6922,7 @@ - formula: C2H4O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: gcald - chebi: CHEBI:17071 - kegg.compound: C00266 - metanetx.chemical: MNXM349 @@ -6382,6 +6934,7 @@ - formula: C2HO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: glx - chebi: CHEBI:36655 - kegg.compound: C00048 - metanetx.chemical: MNXM69 @@ -6393,6 +6946,7 @@ - formula: C2HO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: glx - chebi: CHEBI:36655 - kegg.compound: C00048 - metanetx.chemical: MNXM69 @@ -6404,6 +6958,7 @@ - formula: C2HO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: glx - chebi: CHEBI:36655 - kegg.compound: C00048 - metanetx.chemical: MNXM69 @@ -6415,6 +6970,7 @@ - formula: C10H12N5O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: gmp - chebi: CHEBI:58115 - kegg.compound: C00144 - metanetx.chemical: MNXM113 @@ -6426,6 +6982,7 @@ - formula: C10H12N5O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: gmp - chebi: CHEBI:58115 - kegg.compound: C00144 - metanetx.chemical: MNXM113 @@ -6434,9 +6991,10 @@ - id: s_0785 - name: GTP - compartment: c - - formula: C10H13N5O14P3 - - charge: -3 + - formula: C10H12N5O14P3 + - charge: -4 - annotation: !!omap + - bigg.metabolite: gtp - chebi: CHEBI:57600 - kegg.compound: C00044 - metanetx.chemical: MNXM51 @@ -6445,9 +7003,10 @@ - id: s_0786 - name: GTP - compartment: m - - formula: C10H13N5O14P3 - - charge: -3 + - formula: C10H12N5O14P3 + - charge: -4 - annotation: !!omap + - bigg.metabolite: gtp - chebi: CHEBI:57600 - kegg.compound: C00044 - metanetx.chemical: MNXM51 @@ -6459,6 +7018,7 @@ - formula: C5H5N5O - charge: 0 - annotation: !!omap + - bigg.metabolite: gua - chebi: CHEBI:16235 - kegg.compound: C00242 - metanetx.chemical: MNXM259 @@ -6470,6 +7030,7 @@ - formula: C5H5N5O - charge: 0 - annotation: !!omap + - bigg.metabolite: gua - chebi: CHEBI:16235 - kegg.compound: C00242 - metanetx.chemical: MNXM259 @@ -6481,6 +7042,7 @@ - formula: C5H5N5O - charge: 0 - annotation: !!omap + - bigg.metabolite: gua - chebi: CHEBI:16235 - kegg.compound: C00242 - metanetx.chemical: MNXM259 @@ -6492,6 +7054,7 @@ - formula: C10H13N5O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: gsn - chebi: CHEBI:16750 - kegg.compound: C00387 - metanetx.chemical: MNXM401 @@ -6503,6 +7066,7 @@ - formula: C10H13N5O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: gsn - chebi: CHEBI:16750 - kegg.compound: C00387 - metanetx.chemical: MNXM401 @@ -6514,6 +7078,7 @@ - formula: C10H13N5O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: gsn - chebi: CHEBI:16750 - kegg.compound: C00387 - metanetx.chemical: MNXM401 @@ -6525,6 +7090,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -6536,6 +7102,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -6547,6 +7114,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -6558,6 +7126,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -6569,6 +7138,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -6580,6 +7150,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -6591,6 +7162,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -6602,6 +7174,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -6613,6 +7186,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -6624,6 +7198,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -6635,6 +7210,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -6646,6 +7222,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -6657,6 +7234,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -6668,6 +7246,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -6679,6 +7258,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -6690,6 +7270,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -6701,6 +7282,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -6712,6 +7294,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -6720,9 +7303,10 @@ - id: s_0811 - name: heme a - compartment: m - - formula: C49H56FeN4O6 - - charge: 0 + - formula: C49H55FeN4O6 + - charge: -3 - annotation: !!omap + - bigg.metabolite: hemeA - chebi: CHEBI:24479 - kegg.compound: C15670 - metanetx.chemical: MNXM53309 @@ -6731,9 +7315,10 @@ - id: s_0812 - name: heme o - compartment: m - - formula: C49H58FeN4O5 - - charge: 0 + - formula: C49H56FeN4O5 + - charge: -2 - annotation: !!omap + - bigg.metabolite: hemeO - chebi: CHEBI:24480 - kegg.compound: C15672 - metanetx.chemical: MNXM1278 @@ -6742,8 +7327,8 @@ - id: s_0813 - name: henicosaprenyl diphosphate - compartment: lp - - formula: C105H172O7P2 - - charge: 0 + - formula: C105H169O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53032 - metanetx.chemical: MNXM56060 @@ -6752,8 +7337,8 @@ - id: s_0814 - name: heptadecaprenyl diphosphate - compartment: lp - - formula: C85H140O7P2 - - charge: 0 + - formula: C85H137O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53036 - metanetx.chemical: MNXM56121 @@ -6762,9 +7347,10 @@ - id: s_0815 - name: heptaprenyl diphosphate - compartment: lp - - formula: C35H60O7P2 - - charge: 0 + - formula: C35H57O7P2 + - charge: -3 - annotation: !!omap + - bigg.metabolite: hepdp - chebi: CHEBI:53046 - kegg.compound: C04216 - metanetx.chemical: MNXM1722 @@ -6773,9 +7359,10 @@ - id: s_0816 - name: hexacosanoyl-CoA - compartment: c - - formula: C47H86N7O17P3S - - charge: 0 + - formula: C47H82N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: hexccoa - chebi: CHEBI:52966 - metanetx.chemical: MNXM1190 - sbo: SBO:0000247 @@ -6783,9 +7370,10 @@ - id: s_0817 - name: hexacosanoyl-CoA - compartment: er - - formula: C47H86N7O17P3S - - charge: 0 + - formula: C47H82N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: hexccoa - chebi: CHEBI:52966 - metanetx.chemical: MNXM1190 - sbo: SBO:0000247 @@ -6793,9 +7381,10 @@ - id: s_0819 - name: hexacosanoyl-CoA - compartment: p - - formula: C47H86N7O17P3S - - charge: 0 + - formula: C47H82N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: hexccoa - chebi: CHEBI:52966 - metanetx.chemical: MNXM1190 - sbo: SBO:0000247 @@ -6803,9 +7392,11 @@ - id: s_0823 - name: hexadec-2-enoyl-CoA - compartment: p - - formula: C37H64N7O17P3S - - charge: 0 + - formula: C37H60N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: hdd2coa + - kegg.compound: C05272 - metanetx.chemical: MNXM581 - sbo: SBO:0000247 - !!omap @@ -6815,6 +7406,7 @@ - formula: C16H32O - charge: 0 - annotation: !!omap + - bigg.metabolite: hxdcal - chebi: CHEBI:17600 - kegg.compound: C00517 - metanetx.chemical: MNXM528 @@ -6826,6 +7418,7 @@ - formula: C16H32O - charge: 0 - annotation: !!omap + - bigg.metabolite: hxdcal - chebi: CHEBI:17600 - kegg.compound: C00517 - metanetx.chemical: MNXM528 @@ -6834,8 +7427,8 @@ - id: s_0829 - name: hexadecaprenyl diphosphate - compartment: lp - - formula: C80H132O7P2 - - charge: 0 + - formula: C80H129O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53037 - metanetx.chemical: MNXM56347 @@ -6844,9 +7437,10 @@ - id: s_0830 - name: hexaprenyl diphosphate - compartment: lp - - formula: C30H52O7P2 - - charge: 0 + - formula: C30H49O7P2 + - charge: -3 - annotation: !!omap + - bigg.metabolite: hexdp - chebi: CHEBI:53047 - kegg.compound: C01230 - metanetx.chemical: MNXM1067 @@ -6855,9 +7449,10 @@ - id: s_0831 - name: hexaprenyl diphosphate - compartment: m - - formula: C30H52O7P2 - - charge: 0 + - formula: C30H49O7P2 + - charge: -3 - annotation: !!omap + - bigg.metabolite: hexdp - chebi: CHEBI:53047 - kegg.compound: C01230 - metanetx.chemical: MNXM1067 @@ -6866,9 +7461,10 @@ - id: s_0832 - name: His-tRNA(His) - compartment: c - - formula: C6H8N3OR - - charge: 0 + - formula: C6H9N3OR + - charge: 1 - annotation: !!omap + - bigg.metabolite: histrna - chebi: CHEBI:29155 - kegg.compound: C02988 - metanetx.chemical: MNXM89831 @@ -6877,9 +7473,10 @@ - id: s_0833 - name: His-tRNA(His) - compartment: m - - formula: C6H8N3OR - - charge: 0 + - formula: C6H9N3OR + - charge: 1 - annotation: !!omap + - bigg.metabolite: histrna - chebi: CHEBI:29155 - kegg.compound: C02988 - metanetx.chemical: MNXM89831 @@ -6893,7 +7490,7 @@ - annotation: !!omap - chebi: CHEBI:36457 - kegg.compound: C01251 - - metanetx.chemical: MNXM1056 + - metanetx.chemical: MNXM722779 - sbo: SBO:0000247 - !!omap - id: s_0835 @@ -6904,7 +7501,7 @@ - annotation: !!omap - chebi: CHEBI:36457 - kegg.compound: C01251 - - metanetx.chemical: MNXM1056 + - metanetx.chemical: MNXM722779 - sbo: SBO:0000247 - !!omap - id: s_0836 @@ -6913,6 +7510,7 @@ - formula: C7H7O7 - charge: -3 - annotation: !!omap + - bigg.metabolite: hicit - chebi: CHEBI:30904 - kegg.compound: C05662 - metanetx.chemical: MNXM984 @@ -6924,6 +7522,7 @@ - formula: H2O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o2 - chebi: CHEBI:16240 - kegg.compound: C00027 - metanetx.chemical: MNXM22 @@ -6935,6 +7534,7 @@ - formula: H2O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o2 - chebi: CHEBI:16240 - kegg.compound: C00027 - metanetx.chemical: MNXM22 @@ -6946,6 +7546,7 @@ - formula: H2O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o2 - chebi: CHEBI:16240 - kegg.compound: C00027 - metanetx.chemical: MNXM22 @@ -6957,6 +7558,7 @@ - formula: H2O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o2 - chebi: CHEBI:16240 - kegg.compound: C00027 - metanetx.chemical: MNXM22 @@ -6968,6 +7570,7 @@ - formula: HS - charge: -1 - annotation: !!omap + - bigg.metabolite: h2s - chebi: CHEBI:29919 - kegg.compound: C00283 - metanetx.chemical: MNXM89582 @@ -6979,6 +7582,7 @@ - formula: C5H4N4O - charge: 0 - annotation: !!omap + - bigg.metabolite: hxan - chebi: CHEBI:17368 - kegg.compound: C00262 - metanetx.chemical: MNXM213 @@ -6990,6 +7594,7 @@ - formula: C5H4N4O - charge: 0 - annotation: !!omap + - bigg.metabolite: hxan - chebi: CHEBI:17368 - kegg.compound: C00262 - metanetx.chemical: MNXM213 @@ -6998,8 +7603,8 @@ - id: s_0845 - name: icosaprenyl diphosphate - compartment: lp - - formula: C100H164O7P2 - - charge: 0 + - formula: C100H161O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53033 - metanetx.chemical: MNXM57076 @@ -7011,6 +7616,7 @@ - formula: C10H11N4O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: idp - chebi: CHEBI:58280 - kegg.compound: C00104 - metanetx.chemical: MNXM495 @@ -7019,9 +7625,10 @@ - id: s_0847 - name: Ile-tRNA(Ile) - compartment: c - - formula: C6H12NOR - - charge: 0 + - formula: C6H13NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: iletrna - chebi: CHEBI:29160 - kegg.compound: C03127 - metanetx.chemical: MNXM89832 @@ -7030,9 +7637,10 @@ - id: s_0848 - name: Ile-tRNA(Ile) - compartment: m - - formula: C6H12NOR - - charge: 0 + - formula: C6H13NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: iletrna - chebi: CHEBI:29160 - kegg.compound: C03127 - metanetx.chemical: MNXM89832 @@ -7044,6 +7652,7 @@ - formula: C10H11N4O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: imp - chebi: CHEBI:58053 - kegg.compound: C00130 - metanetx.chemical: MNXM125 @@ -7055,6 +7664,7 @@ - formula: C10H9NO - charge: 0 - annotation: !!omap + - bigg.metabolite: id3acald - chebi: CHEBI:18086 - kegg.compound: C00637 - metanetx.chemical: MNXM518 @@ -7066,6 +7676,7 @@ - formula: C10H9NO - charge: 0 - annotation: !!omap + - bigg.metabolite: id3acald - chebi: CHEBI:18086 - kegg.compound: C00637 - metanetx.chemical: MNXM518 @@ -7077,6 +7688,7 @@ - formula: C10H9NO - charge: 0 - annotation: !!omap + - bigg.metabolite: id3acald - chebi: CHEBI:18086 - kegg.compound: C00637 - metanetx.chemical: MNXM518 @@ -7088,6 +7700,7 @@ - formula: C10H8NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ind3ac - chebi: CHEBI:30854 - kegg.compound: C00954 - metanetx.chemical: MNXM383 @@ -7099,6 +7712,7 @@ - formula: C10H8NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ind3ac - chebi: CHEBI:30854 - kegg.compound: C00954 - metanetx.chemical: MNXM383 @@ -7110,6 +7724,7 @@ - formula: C11H8NO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: indpyr - chebi: CHEBI:17640 - kegg.compound: C00331 - metanetx.chemical: MNXM315 @@ -7121,6 +7736,7 @@ - formula: C10H12N4O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: ins - chebi: CHEBI:17596 - kegg.compound: C00294 - metanetx.chemical: MNXM334 @@ -7132,6 +7748,7 @@ - formula: C10H12N4O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: ins - chebi: CHEBI:17596 - kegg.compound: C00294 - metanetx.chemical: MNXM334 @@ -7762,6 +8379,7 @@ - formula: Fe - charge: 2 - annotation: !!omap + - bigg.metabolite: fe2 - chebi: CHEBI:29033 - kegg.compound: C14818 - metanetx.chemical: MNXM111 @@ -7773,6 +8391,7 @@ - formula: Fe - charge: 2 - annotation: !!omap + - bigg.metabolite: fe2 - chebi: CHEBI:29033 - kegg.compound: C14818 - metanetx.chemical: MNXM111 @@ -7784,6 +8403,7 @@ - formula: Fe - charge: 2 - annotation: !!omap + - bigg.metabolite: fe2 - chebi: CHEBI:29033 - kegg.compound: C14818 - metanetx.chemical: MNXM111 @@ -7795,6 +8415,7 @@ - formula: C7H14O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: iamac - chebi: CHEBI:31725 - kegg.compound: C12296 - metanetx.chemical: MNXM7451 @@ -7806,6 +8427,7 @@ - formula: C7H14O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: iamac - chebi: CHEBI:31725 - kegg.compound: C12296 - metanetx.chemical: MNXM7451 @@ -7817,6 +8439,7 @@ - formula: C5H12O - charge: 0 - annotation: !!omap + - bigg.metabolite: iamoh - chebi: CHEBI:15837 - kegg.compound: C07328 - metanetx.chemical: MNXM1670 @@ -7828,6 +8451,7 @@ - formula: C5H12O - charge: 0 - annotation: !!omap + - bigg.metabolite: iamoh - chebi: CHEBI:15837 - kegg.compound: C07328 - metanetx.chemical: MNXM1670 @@ -7839,6 +8463,7 @@ - formula: C5H12O - charge: 0 - annotation: !!omap + - bigg.metabolite: iamoh - chebi: CHEBI:15837 - kegg.compound: C07328 - metanetx.chemical: MNXM1670 @@ -7850,6 +8475,7 @@ - formula: C4H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: ibutoh - chebi: CHEBI:46645 - kegg.compound: C14710 - metanetx.chemical: MNXM5188 @@ -7861,6 +8487,7 @@ - formula: C4H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: ibutoh - chebi: CHEBI:46645 - kegg.compound: C14710 - metanetx.chemical: MNXM5188 @@ -7872,6 +8499,7 @@ - formula: C4H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: ibutoh - chebi: CHEBI:46645 - kegg.compound: C14710 - metanetx.chemical: MNXM5188 @@ -7883,6 +8511,7 @@ - formula: C6H12O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ibutac - chebi: CHEBI:50569 - metanetx.chemical: MNXM57835 - sbo: SBO:0000247 @@ -7893,6 +8522,7 @@ - formula: C6H12O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ibutac - chebi: CHEBI:50569 - metanetx.chemical: MNXM57835 - sbo: SBO:0000247 @@ -7903,6 +8533,7 @@ - formula: C4H8O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mppal - chebi: CHEBI:48943 - metanetx.chemical: MNXM5189 - sbo: SBO:0000247 @@ -7913,6 +8544,7 @@ - formula: C4H8O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mppal - chebi: CHEBI:48943 - metanetx.chemical: MNXM5189 - sbo: SBO:0000247 @@ -7923,6 +8555,7 @@ - formula: C4H8O - charge: 0 - annotation: !!omap + - bigg.metabolite: 2mppal - chebi: CHEBI:48943 - metanetx.chemical: MNXM5189 - sbo: SBO:0000247 @@ -7933,6 +8566,7 @@ - formula: C6H5O7 - charge: -3 - annotation: !!omap + - bigg.metabolite: icit - chebi: CHEBI:16087 - kegg.compound: C00311 - metanetx.chemical: MNXM89661 @@ -7944,6 +8578,7 @@ - formula: C6H5O7 - charge: -3 - annotation: !!omap + - bigg.metabolite: icit - chebi: CHEBI:16087 - kegg.compound: C00311 - metanetx.chemical: MNXM89661 @@ -7955,6 +8590,7 @@ - formula: C6H5O7 - charge: -3 - annotation: !!omap + - bigg.metabolite: icit - chebi: CHEBI:16087 - kegg.compound: C00311 - metanetx.chemical: MNXM89661 @@ -7966,6 +8602,7 @@ - formula: C5H9O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ipdp - chebi: CHEBI:128769 - kegg.compound: C00129 - metanetx.chemical: MNXM83 @@ -7977,6 +8614,7 @@ - formula: C5H9O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ipdp - chebi: CHEBI:128769 - kegg.compound: C00129 - metanetx.chemical: MNXM83 @@ -7988,6 +8626,7 @@ - formula: C5H9O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ipdp - chebi: CHEBI:128769 - kegg.compound: C00129 - metanetx.chemical: MNXM83 @@ -7999,6 +8638,7 @@ - formula: C5H4O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: itacon - chebi: CHEBI:17240 - kegg.compound: C00490 - metanetx.chemical: MNXM1747 @@ -8010,6 +8650,7 @@ - formula: C26H35N7O19P3S - charge: -5 - annotation: !!omap + - bigg.metabolite: itaccoa - chebi: CHEBI:57381 - kegg.compound: C00531 - metanetx.chemical: MNXM1671 @@ -8021,6 +8662,7 @@ - formula: C10H11N4O14P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: itp - chebi: CHEBI:61402 - kegg.compound: C00081 - metanetx.chemical: MNXM423 @@ -8032,6 +8674,7 @@ - formula: C9H7O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: phpyr - chebi: CHEBI:18005 - kegg.compound: C00166 - metanetx.chemical: MNXM162242 @@ -8043,6 +8686,7 @@ - formula: C4H7NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: 2aobut - chebi: CHEBI:40673 - kegg.compound: C03508 - metanetx.chemical: MNXM114087 @@ -8054,6 +8698,7 @@ - formula: C6H10NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: L2aadp - chebi: CHEBI:58672 - kegg.compound: C00956 - metanetx.chemical: MNXM268 @@ -8065,6 +8710,7 @@ - formula: C5H9NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: 4hglusa - chebi: CHEBI:27809 - kegg.compound: C05938 - metanetx.chemical: MNXM2687 @@ -8076,6 +8722,7 @@ - formula: C3H7NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala__L - chebi: CHEBI:16977 - kegg.compound: C00041 - metanetx.chemical: MNXM32 @@ -8087,6 +8734,7 @@ - formula: C3H7NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala__L - chebi: CHEBI:16977 - kegg.compound: C00041 - metanetx.chemical: MNXM32 @@ -8098,6 +8746,7 @@ - formula: C3H7NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala__L - chebi: CHEBI:16977 - kegg.compound: C00041 - metanetx.chemical: MNXM32 @@ -8109,6 +8758,7 @@ - formula: C4H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: athr__L - chebi: CHEBI:28718 - kegg.compound: C05519 - metanetx.chemical: MNXM2125 @@ -8120,6 +8770,7 @@ - formula: C6H11NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: L2aadp6sa - chebi: CHEBI:17917 - kegg.compound: C04076 - metanetx.chemical: MNXM89905 @@ -8128,9 +8779,10 @@ - id: s_0960 - name: L-alpha-formylglycine - compartment: c - - formula: C3H4NO3 - - charge: -1 + - formula: C3H5NO3 + - charge: 0 - annotation: !!omap + - bigg.metabolite: 2amsa - chebi: CHEBI:58671 - kegg.compound: C11822 - metanetx.chemical: MNXM2124 @@ -8142,6 +8794,7 @@ - formula: C5H12O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: abt - chebi: CHEBI:18403 - kegg.compound: C00532 - metanetx.chemical: MNXM801 @@ -8153,6 +8806,7 @@ - formula: C5H12O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: abt - chebi: CHEBI:18403 - kegg.compound: C00532 - metanetx.chemical: MNXM801 @@ -8164,6 +8818,7 @@ - formula: C5H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: arab__L - chebi: CHEBI:30849 - kegg.compound: C00259 - metanetx.chemical: MNXM461 @@ -8175,6 +8830,7 @@ - formula: C5H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: arab__L - chebi: CHEBI:30849 - kegg.compound: C00259 - metanetx.chemical: MNXM461 @@ -8186,6 +8842,7 @@ - formula: C6H15N4O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: arg__L - chebi: CHEBI:32682 - kegg.compound: C00062 - metanetx.chemical: MNXM70 @@ -8197,6 +8854,7 @@ - formula: C6H15N4O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: arg__L - chebi: CHEBI:32682 - kegg.compound: C00062 - metanetx.chemical: MNXM70 @@ -8208,6 +8866,7 @@ - formula: C6H15N4O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: arg__L - chebi: CHEBI:32682 - kegg.compound: C00062 - metanetx.chemical: MNXM70 @@ -8219,6 +8878,7 @@ - formula: C6H15N4O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: arg__L - chebi: CHEBI:32682 - kegg.compound: C00062 - metanetx.chemical: MNXM70 @@ -8230,6 +8890,7 @@ - formula: C4H8N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: asn__L - chebi: CHEBI:17196 - kegg.compound: C00152 - metanetx.chemical: MNXM147 @@ -8241,6 +8902,7 @@ - formula: C4H8N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: asn__L - chebi: CHEBI:17196 - kegg.compound: C00152 - metanetx.chemical: MNXM147 @@ -8252,6 +8914,7 @@ - formula: C4H8N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: asn__L - chebi: CHEBI:17196 - kegg.compound: C00152 - metanetx.chemical: MNXM147 @@ -8263,6 +8926,7 @@ - formula: C4H8N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: asn__L - chebi: CHEBI:17196 - kegg.compound: C00152 - metanetx.chemical: MNXM147 @@ -8274,6 +8938,7 @@ - formula: C4H6NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: asp__L - chebi: CHEBI:29991 - kegg.compound: C00049 - metanetx.chemical: MNXM42 @@ -8285,6 +8950,7 @@ - formula: C4H6NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: asp__L - chebi: CHEBI:29991 - kegg.compound: C00049 - metanetx.chemical: MNXM42 @@ -8296,6 +8962,7 @@ - formula: C4H6NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: asp__L - chebi: CHEBI:29991 - kegg.compound: C00049 - metanetx.chemical: MNXM42 @@ -8307,6 +8974,7 @@ - formula: C4H6NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: asp__L - chebi: CHEBI:29991 - kegg.compound: C00049 - metanetx.chemical: MNXM42 @@ -8318,6 +8986,7 @@ - formula: C4H6NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: asp__L - chebi: CHEBI:29991 - kegg.compound: C00049 - metanetx.chemical: MNXM42 @@ -8329,6 +8998,7 @@ - formula: C4H7NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: aspsa - chebi: CHEBI:18051 - kegg.compound: C00441 - metanetx.chemical: MNXM361 @@ -8340,6 +9010,7 @@ - formula: C6H13N3O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: citr__L - chebi: CHEBI:16349 - kegg.compound: C00327 - metanetx.chemical: MNXM211 @@ -8351,6 +9022,7 @@ - formula: C7H14N2O4S - charge: 0 - annotation: !!omap + - bigg.metabolite: cyst__L - chebi: CHEBI:17482 - kegg.compound: C02291 - metanetx.chemical: MNXM319 @@ -8362,6 +9034,7 @@ - formula: C3H7NO2S - charge: 0 - annotation: !!omap + - bigg.metabolite: cys__L - chebi: CHEBI:17561 - kegg.compound: C00097 - metanetx.chemical: MNXM55 @@ -8373,6 +9046,7 @@ - formula: C3H7NO2S - charge: 0 - annotation: !!omap + - bigg.metabolite: cys__L - chebi: CHEBI:17561 - kegg.compound: C00097 - metanetx.chemical: MNXM55 @@ -8384,6 +9058,7 @@ - formula: C5H10N2O3S - charge: 0 - annotation: !!omap + - bigg.metabolite: cgly - chebi: CHEBI:4047 - kegg.compound: C01419 - metanetx.chemical: MNXM683 @@ -8395,6 +9070,7 @@ - formula: C6H12N2O4S2 - charge: 0 - annotation: !!omap + - bigg.metabolite: cysi__L - chebi: CHEBI:16283 - kegg.compound: C00491 - metanetx.chemical: MNXM927 @@ -8406,6 +9082,7 @@ - formula: C6H12N2O4S2 - charge: 0 - annotation: !!omap + - bigg.metabolite: cysi__L - chebi: CHEBI:16283 - kegg.compound: C00491 - metanetx.chemical: MNXM927 @@ -8417,6 +9094,7 @@ - formula: C5H8NO7P - charge: -2 - annotation: !!omap + - bigg.metabolite: glu5p - chebi: CHEBI:58274 - kegg.compound: C03287 - metanetx.chemical: MNXM1280 @@ -8425,9 +9103,10 @@ - id: s_0987 - name: L-gamma-glutamyl-L-alanine - compartment: c - - formula: C8H14N2O5 - - charge: 0 + - formula: C8H13N2O5 + - charge: -1 - annotation: !!omap + - bigg.metabolite: gluala - chebi: CHEBI:50619 - kegg.compound: C03738 - metanetx.chemical: MNXM59390 @@ -8439,6 +9118,7 @@ - formula: C8H13N2O5S - charge: -1 - annotation: !!omap + - bigg.metabolite: glucys - chebi: CHEBI:58173 - kegg.compound: C00669 - metanetx.chemical: MNXM412 @@ -8450,6 +9130,7 @@ - formula: C6H14O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: sbt__L - chebi: CHEBI:28789 - kegg.compound: C01722 - metanetx.chemical: MNXM4638 @@ -8461,6 +9142,7 @@ - formula: C6H14O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: sbt__L - chebi: CHEBI:28789 - kegg.compound: C01722 - metanetx.chemical: MNXM4638 @@ -8472,6 +9154,7 @@ - formula: C5H8NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: glu__L - chebi: CHEBI:29985 - kegg.compound: C00025 - metanetx.chemical: MNXM89557 @@ -8483,6 +9166,7 @@ - formula: C5H8NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: glu__L - chebi: CHEBI:29985 - kegg.compound: C00025 - metanetx.chemical: MNXM89557 @@ -8494,6 +9178,7 @@ - formula: C5H8NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: glu__L - chebi: CHEBI:29985 - kegg.compound: C00025 - metanetx.chemical: MNXM89557 @@ -8505,6 +9190,7 @@ - formula: C5H8NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: glu__L - chebi: CHEBI:29985 - kegg.compound: C00025 - metanetx.chemical: MNXM89557 @@ -8516,6 +9202,7 @@ - formula: C5H8NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: glu__L - chebi: CHEBI:29985 - kegg.compound: C00025 - metanetx.chemical: MNXM89557 @@ -8527,6 +9214,7 @@ - formula: C5H8NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: glu__L - chebi: CHEBI:29985 - kegg.compound: C00025 - metanetx.chemical: MNXM89557 @@ -8538,6 +9226,7 @@ - formula: C5H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: glu5sa - chebi: CHEBI:17232 - kegg.compound: C01165 - metanetx.chemical: MNXM245 @@ -8549,6 +9238,7 @@ - formula: C5H10N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: gln__L - chebi: CHEBI:18050 - kegg.compound: C00064 - metanetx.chemical: MNXM37 @@ -8560,6 +9250,7 @@ - formula: C5H10N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: gln__L - chebi: CHEBI:18050 - kegg.compound: C00064 - metanetx.chemical: MNXM37 @@ -8571,6 +9262,7 @@ - formula: C5H10N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: gln__L - chebi: CHEBI:18050 - kegg.compound: C00064 - metanetx.chemical: MNXM37 @@ -8582,6 +9274,7 @@ - formula: C5H10N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: gln__L - chebi: CHEBI:18050 - kegg.compound: C00064 - metanetx.chemical: MNXM37 @@ -8593,6 +9286,7 @@ - formula: C2H5NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: gly - chebi: CHEBI:15428 - kegg.compound: C00037 - metanetx.chemical: MNXM29 @@ -8604,6 +9298,7 @@ - formula: C2H5NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: gly - chebi: CHEBI:15428 - kegg.compound: C00037 - metanetx.chemical: MNXM29 @@ -8615,6 +9310,7 @@ - formula: C2H5NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: gly - chebi: CHEBI:15428 - kegg.compound: C00037 - metanetx.chemical: MNXM29 @@ -8626,6 +9322,7 @@ - formula: C6H9N3O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: his__L - chebi: CHEBI:15971 - kegg.compound: C00135 - metanetx.chemical: MNXM134 @@ -8637,6 +9334,7 @@ - formula: C6H9N3O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: his__L - chebi: CHEBI:15971 - kegg.compound: C00135 - metanetx.chemical: MNXM134 @@ -8648,6 +9346,7 @@ - formula: C6H9N3O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: his__L - chebi: CHEBI:15971 - kegg.compound: C00135 - metanetx.chemical: MNXM134 @@ -8659,6 +9358,7 @@ - formula: C6H9N3O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: his__L - chebi: CHEBI:15971 - kegg.compound: C00135 - metanetx.chemical: MNXM134 @@ -8670,6 +9370,7 @@ - formula: C6H12N3O - charge: 1 - annotation: !!omap + - bigg.metabolite: histd - chebi: CHEBI:57699 - kegg.compound: C00860 - metanetx.chemical: MNXM1281 @@ -8681,6 +9382,7 @@ - formula: C6H11N3O4P - charge: -1 - annotation: !!omap + - bigg.metabolite: hisp - chebi: CHEBI:57980 - kegg.compound: C01100 - metanetx.chemical: MNXM1482 @@ -8692,6 +9394,7 @@ - formula: C4H9NO2S - charge: 0 - annotation: !!omap + - bigg.metabolite: hcys__L - chebi: CHEBI:17588 - kegg.compound: C00155 - metanetx.chemical: MNXM123 @@ -8703,6 +9406,7 @@ - formula: C4H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: hom__L - chebi: CHEBI:15699 - kegg.compound: C00263 - metanetx.chemical: MNXM353 @@ -8714,6 +9418,7 @@ - formula: C4H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: hom__L - chebi: CHEBI:15699 - kegg.compound: C00263 - metanetx.chemical: MNXM353 @@ -8725,6 +9430,7 @@ - formula: C6H13NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ile__L - chebi: CHEBI:17191 - kegg.compound: C00407 - metanetx.chemical: MNXM231 @@ -8736,6 +9442,7 @@ - formula: C6H13NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ile__L - chebi: CHEBI:17191 - kegg.compound: C00407 - metanetx.chemical: MNXM231 @@ -8747,6 +9454,7 @@ - formula: C6H13NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ile__L - chebi: CHEBI:17191 - kegg.compound: C00407 - metanetx.chemical: MNXM231 @@ -8758,6 +9466,7 @@ - formula: C6H13NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ile__L - chebi: CHEBI:17191 - kegg.compound: C00407 - metanetx.chemical: MNXM231 @@ -8769,6 +9478,7 @@ - formula: C10H12N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: Lkynr - chebi: CHEBI:16946 - kegg.compound: C00328 - metanetx.chemical: MNXM260 @@ -8780,6 +9490,7 @@ - formula: C6H13NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: leu__L - chebi: CHEBI:15603 - kegg.compound: C00123 - metanetx.chemical: MNXM140 @@ -8791,6 +9502,7 @@ - formula: C6H13NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: leu__L - chebi: CHEBI:15603 - kegg.compound: C00123 - metanetx.chemical: MNXM140 @@ -8802,6 +9514,7 @@ - formula: C6H13NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: leu__L - chebi: CHEBI:15603 - kegg.compound: C00123 - metanetx.chemical: MNXM140 @@ -8813,6 +9526,7 @@ - formula: C6H13NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: leu__L - chebi: CHEBI:15603 - kegg.compound: C00123 - metanetx.chemical: MNXM140 @@ -8824,6 +9538,7 @@ - formula: C6H15N2O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: lys__L - chebi: CHEBI:32551 - kegg.compound: C00047 - metanetx.chemical: MNXM78 @@ -8835,6 +9550,7 @@ - formula: C6H15N2O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: lys__L - chebi: CHEBI:32551 - kegg.compound: C00047 - metanetx.chemical: MNXM78 @@ -8846,6 +9562,7 @@ - formula: C6H15N2O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: lys__L - chebi: CHEBI:32551 - kegg.compound: C00047 - metanetx.chemical: MNXM78 @@ -8857,6 +9574,7 @@ - formula: C6H15N2O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: lys__L - chebi: CHEBI:32551 - kegg.compound: C00047 - metanetx.chemical: MNXM78 @@ -8868,6 +9586,7 @@ - formula: C5H11NO2S - charge: 0 - annotation: !!omap + - bigg.metabolite: met__L - chebi: CHEBI:16643 - kegg.compound: C00073 - metanetx.chemical: MNXM61 @@ -8879,6 +9598,7 @@ - formula: C5H11NO2S - charge: 0 - annotation: !!omap + - bigg.metabolite: met__L - chebi: CHEBI:16643 - kegg.compound: C00073 - metanetx.chemical: MNXM61 @@ -8890,6 +9610,7 @@ - formula: C5H11NO2S - charge: 0 - annotation: !!omap + - bigg.metabolite: met__L - chebi: CHEBI:16643 - kegg.compound: C00073 - metanetx.chemical: MNXM61 @@ -8901,6 +9622,7 @@ - formula: C9H11NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: phe__L - chebi: CHEBI:17295 - kegg.compound: C00079 - metanetx.chemical: MNXM97 @@ -8912,6 +9634,7 @@ - formula: C9H11NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: phe__L - chebi: CHEBI:17295 - kegg.compound: C00079 - metanetx.chemical: MNXM97 @@ -8923,6 +9646,7 @@ - formula: C9H11NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: phe__L - chebi: CHEBI:17295 - kegg.compound: C00079 - metanetx.chemical: MNXM97 @@ -8934,6 +9658,7 @@ - formula: C5H9NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pro__L - chebi: CHEBI:17203 - kegg.compound: C00148 - metanetx.chemical: MNXM114 @@ -8945,6 +9670,7 @@ - formula: C5H9NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pro__L - chebi: CHEBI:17203 - kegg.compound: C00148 - metanetx.chemical: MNXM114 @@ -8956,6 +9682,7 @@ - formula: C5H9NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pro__L - chebi: CHEBI:17203 - kegg.compound: C00148 - metanetx.chemical: MNXM114 @@ -8967,6 +9694,7 @@ - formula: C11H19N2O6 - charge: -1 - annotation: !!omap + - bigg.metabolite: saccrp__L - chebi: CHEBI:57951 - kegg.compound: C00449 - metanetx.chemical: MNXM384 @@ -8978,6 +9706,7 @@ - formula: C3H7NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ser__L - chebi: CHEBI:17115 - kegg.compound: C00065 - metanetx.chemical: MNXM53 @@ -8989,6 +9718,7 @@ - formula: C3H7NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ser__L - chebi: CHEBI:17115 - kegg.compound: C00065 - metanetx.chemical: MNXM53 @@ -9000,6 +9730,7 @@ - formula: C3H7NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ser__L - chebi: CHEBI:17115 - kegg.compound: C00065 - metanetx.chemical: MNXM53 @@ -9011,6 +9742,7 @@ - formula: C3H7NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ser__L - chebi: CHEBI:17115 - kegg.compound: C00065 - metanetx.chemical: MNXM53 @@ -9022,6 +9754,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: srb__L - chebi: CHEBI:17266 - kegg.compound: C00247 - metanetx.chemical: MNXM588 @@ -9033,6 +9766,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: srb__L - chebi: CHEBI:17266 - kegg.compound: C00247 - metanetx.chemical: MNXM588 @@ -9044,6 +9778,7 @@ - formula: C4H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: thr__L - chebi: CHEBI:16857 - kegg.compound: C00188 - metanetx.chemical: MNXM142 @@ -9055,6 +9790,7 @@ - formula: C4H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: thr__L - chebi: CHEBI:16857 - kegg.compound: C00188 - metanetx.chemical: MNXM142 @@ -9066,6 +9802,7 @@ - formula: C4H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: thr__L - chebi: CHEBI:16857 - kegg.compound: C00188 - metanetx.chemical: MNXM142 @@ -9077,6 +9814,7 @@ - formula: C11H12N2O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: trp__L - chebi: CHEBI:16828 - kegg.compound: C00078 - metanetx.chemical: MNXM94 @@ -9088,6 +9826,7 @@ - formula: C11H12N2O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: trp__L - chebi: CHEBI:16828 - kegg.compound: C00078 - metanetx.chemical: MNXM94 @@ -9099,6 +9838,7 @@ - formula: C11H12N2O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: trp__L - chebi: CHEBI:16828 - kegg.compound: C00078 - metanetx.chemical: MNXM94 @@ -9110,6 +9850,7 @@ - formula: C9H11NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: tyr__L - chebi: CHEBI:17895 - kegg.compound: C00082 - metanetx.chemical: MNXM76 @@ -9121,6 +9862,7 @@ - formula: C9H11NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: tyr__L - chebi: CHEBI:17895 - kegg.compound: C00082 - metanetx.chemical: MNXM76 @@ -9132,6 +9874,7 @@ - formula: C9H11NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: tyr__L - chebi: CHEBI:17895 - kegg.compound: C00082 - metanetx.chemical: MNXM76 @@ -9143,6 +9886,7 @@ - formula: C9H11NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: tyr__L - chebi: CHEBI:17895 - kegg.compound: C00082 - metanetx.chemical: MNXM76 @@ -9154,6 +9898,7 @@ - formula: C9H11NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: tyr__L - chebi: CHEBI:17895 - kegg.compound: C00082 - metanetx.chemical: MNXM76 @@ -9165,6 +9910,7 @@ - formula: C5H11NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: val__L - chebi: CHEBI:16414 - kegg.compound: C00183 - metanetx.chemical: MNXM199 @@ -9176,6 +9922,7 @@ - formula: C5H11NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: val__L - chebi: CHEBI:16414 - kegg.compound: C00183 - metanetx.chemical: MNXM199 @@ -9187,6 +9934,7 @@ - formula: C5H11NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: val__L - chebi: CHEBI:16414 - kegg.compound: C00183 - metanetx.chemical: MNXM199 @@ -9198,6 +9946,7 @@ - formula: C30H50O - charge: 0 - annotation: !!omap + - bigg.metabolite: lanost - chebi: CHEBI:16521 - kegg.compound: C01724 - metanetx.chemical: MNXM482 @@ -9209,6 +9958,7 @@ - formula: C30H50O - charge: 0 - annotation: !!omap + - bigg.metabolite: lanost - chebi: CHEBI:16521 - kegg.compound: C01724 - metanetx.chemical: MNXM482 @@ -9220,6 +9970,7 @@ - formula: C12H23O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ddca - chebi: CHEBI:18262 - kegg.compound: C02679 - metanetx.chemical: MNXM402 @@ -9231,6 +9982,7 @@ - formula: C12H23O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ddca - chebi: CHEBI:18262 - kegg.compound: C02679 - metanetx.chemical: MNXM402 @@ -9242,6 +9994,7 @@ - formula: C12H23O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ddca - chebi: CHEBI:18262 - kegg.compound: C02679 - metanetx.chemical: MNXM402 @@ -9253,6 +10006,7 @@ - formula: C33H54N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ddcacoa - chebi: CHEBI:57375 - kegg.compound: C01832 - metanetx.chemical: MNXM363 @@ -9264,6 +10018,7 @@ - formula: C33H54N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ddcacoa - chebi: CHEBI:57375 - kegg.compound: C01832 - metanetx.chemical: MNXM363 @@ -9272,9 +10027,10 @@ - id: s_1077 - name: Leu-tRNA(Leu) - compartment: c - - formula: C6H12NOR - - charge: 0 + - formula: C6H13NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: leutrna - chebi: CHEBI:16624 - kegg.compound: C02047 - metanetx.chemical: MNXM697 @@ -9283,9 +10039,10 @@ - id: s_1078 - name: Leu-tRNA(Leu) - compartment: m - - formula: C6H12NOR - - charge: 0 + - formula: C6H13NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: leutrna - chebi: CHEBI:16624 - kegg.compound: C02047 - metanetx.chemical: MNXM697 @@ -9297,6 +10054,7 @@ - formula: C20H29O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: leuktrA4 - chebi: CHEBI:57463 - kegg.compound: C00909 - metanetx.chemical: MNXM462 @@ -9308,6 +10066,7 @@ - formula: C20H29O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: leuktrA4 - chebi: CHEBI:57463 - kegg.compound: C00909 - metanetx.chemical: MNXM462 @@ -9319,6 +10078,7 @@ - formula: C20H31O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: leuktrB4 - chebi: CHEBI:57461 - kegg.compound: C02165 - metanetx.chemical: MNXM637 @@ -9330,6 +10090,7 @@ - formula: C20H31O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: leuktrB4 - chebi: CHEBI:57461 - kegg.compound: C02165 - metanetx.chemical: MNXM637 @@ -9341,6 +10102,7 @@ - formula: C24H47O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: lgnc - chebi: CHEBI:31014 - kegg.compound: C08320 - metanetx.chemical: MNXM3297 @@ -9362,6 +10124,7 @@ - formula: C8H15NOS2 - charge: 0 - annotation: !!omap + - bigg.metabolite: lpam - chebi: CHEBI:17460 - kegg.compound: C00248 - metanetx.chemical: MNXM1024 @@ -9370,9 +10133,10 @@ - id: s_1098 - name: lipoylprotein - compartment: m - - formula: C12H18N2O4S2R2 + - formula: C8H14NOS2R - charge: 0 - annotation: !!omap + - bigg.metabolite: lpro - chebi: CHEBI:15804 - kegg.compound: C02051 - metanetx.chemical: MNXM998 @@ -9381,9 +10145,10 @@ - id: s_1099 - name: Lys-tRNA(Lys) - compartment: c - - formula: C6H14N2OR - - charge: 0 + - formula: C6H15N2OR + - charge: 2 - annotation: !!omap + - bigg.metabolite: lystrna - chebi: CHEBI:16047 - kegg.compound: C01931 - metanetx.chemical: MNXM89922 @@ -9392,9 +10157,10 @@ - id: s_1100 - name: Lys-tRNA(Lys) - compartment: m - - formula: C6H14N2OR - - charge: 0 + - formula: C6H15N2OR + - charge: 2 - annotation: !!omap + - bigg.metabolite: lystrna - chebi: CHEBI:16047 - kegg.compound: C01931 - metanetx.chemical: MNXM89922 @@ -9406,6 +10172,7 @@ - formula: C24H33N7O19P3S - charge: -5 - annotation: !!omap + - bigg.metabolite: malcoa - chebi: CHEBI:57384 - kegg.compound: C00083 - metanetx.chemical: MNXM40 @@ -9417,6 +10184,7 @@ - formula: C24H33N7O19P3S - charge: -5 - annotation: !!omap + - bigg.metabolite: malcoa - chebi: CHEBI:57384 - kegg.compound: C00083 - metanetx.chemical: MNXM40 @@ -9428,6 +10196,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: malt - chebi: CHEBI:17306 - kegg.compound: C00208 - metanetx.chemical: MNXM165 @@ -9439,6 +10208,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: malt - chebi: CHEBI:17306 - kegg.compound: C00208 - metanetx.chemical: MNXM165 @@ -9447,9 +10217,10 @@ - id: s_1107 - name: mannan - compartment: c - - formula: C6H12O6 + - formula: C6H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: mannan - chebi: CHEBI:28808 - kegg.compound: C00464 - metanetx.chemical: MNXM2020 @@ -9458,9 +10229,10 @@ - id: s_1108 - name: mannan - compartment: er - - formula: C6H12O6 + - formula: C6H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: mannan - chebi: CHEBI:28808 - kegg.compound: C00464 - metanetx.chemical: MNXM2020 @@ -9472,6 +10244,7 @@ - formula: C18H34O22P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: man2mi1p__D - chebi: CHEBI:60449 - metanetx.chemical: MNXM61128 - sbo: SBO:0000247 @@ -9482,6 +10255,7 @@ - formula: C18H34O22P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: man2mi1p__D - chebi: CHEBI:60449 - metanetx.chemical: MNXM61128 - sbo: SBO:0000247 @@ -9492,6 +10266,7 @@ - formula: C12H23O14P - charge: 0 - annotation: !!omap + - bigg.metabolite: manmi1p__D - chebi: CHEBI:60448 - metanetx.chemical: MNXM61129 - sbo: SBO:0000247 @@ -9502,6 +10277,7 @@ - formula: C12H23O14P - charge: 0 - annotation: !!omap + - bigg.metabolite: manmi1p__D - chebi: CHEBI:60448 - metanetx.chemical: MNXM61129 - sbo: SBO:0000247 @@ -9818,23 +10594,25 @@ - id: s_1148 - name: Met-tRNA(Met) - compartment: c - - formula: C5H10NOSR - - charge: 0 + - formula: C5H11NOSR + - charge: 1 - annotation: !!omap + - bigg.metabolite: mettrna - chebi: CHEBI:16635 - kegg.compound: C02430 - - metanetx.chemical: MNXM28 + - metanetx.chemical: MNXM90636 - sbo: SBO:0000247 - !!omap - id: s_1149 - name: Met-tRNA(Met) - compartment: m - - formula: C5H10NOSR - - charge: 0 + - formula: C5H11NOSR + - charge: 1 - annotation: !!omap + - bigg.metabolite: mettrna - chebi: CHEBI:16635 - kegg.compound: C02430 - - metanetx.chemical: MNXM28 + - metanetx.chemical: MNXM90636 - sbo: SBO:0000247 - !!omap - id: s_1150 @@ -9843,6 +10621,7 @@ - formula: CH4S - charge: 0 - annotation: !!omap + - bigg.metabolite: ch4s - chebi: CHEBI:16007 - kegg.compound: C00409 - metanetx.chemical: MNXM652 @@ -9854,6 +10633,7 @@ - formula: C3H4O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: mthgxl - chebi: CHEBI:17158 - kegg.compound: C00546 - metanetx.chemical: MNXM310 @@ -9865,6 +10645,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: inost - chebi: CHEBI:17268 - kegg.compound: C00137 - metanetx.chemical: MNXM127 @@ -9876,6 +10657,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: inost - chebi: CHEBI:17268 - kegg.compound: C00137 - metanetx.chemical: MNXM127 @@ -9887,6 +10669,7 @@ - formula: C6H7O21P5 - charge: -10 - annotation: !!omap + - bigg.metabolite: inospp1 - chebi: CHEBI:57733 - kegg.compound: C01284 - metanetx.chemical: MNXM89719 @@ -9898,6 +10681,7 @@ - formula: C6H7O21P5 - charge: -10 - annotation: !!omap + - bigg.metabolite: inospp1 - chebi: CHEBI:57733 - kegg.compound: C01284 - metanetx.chemical: MNXM89719 @@ -9909,6 +10693,7 @@ - formula: C6H6O24P6 - charge: -12 - annotation: !!omap + - bigg.metabolite: minohp - chebi: CHEBI:58130 - kegg.compound: C01204 - metanetx.chemical: MNXM491 @@ -9920,6 +10705,7 @@ - formula: C6H6O24P6 - charge: -12 - annotation: !!omap + - bigg.metabolite: minohp - chebi: CHEBI:58130 - kegg.compound: C01204 - metanetx.chemical: MNXM491 @@ -9931,6 +10717,7 @@ - formula: C14H27O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ttdca - chebi: CHEBI:30807 - kegg.compound: C06424 - metanetx.chemical: MNXM314 @@ -9942,6 +10729,7 @@ - formula: C14H27O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ttdca - chebi: CHEBI:30807 - kegg.compound: C06424 - metanetx.chemical: MNXM314 @@ -9953,6 +10741,7 @@ - formula: C14H27O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ttdca - chebi: CHEBI:30807 - kegg.compound: C06424 - metanetx.chemical: MNXM314 @@ -9964,6 +10753,7 @@ - formula: C35H58N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: tdcoa - chebi: CHEBI:57385 - kegg.compound: C02593 - metanetx.chemical: MNXM224 @@ -9975,6 +10765,7 @@ - formula: C35H58N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: tdcoa - chebi: CHEBI:57385 - kegg.compound: C02593 - metanetx.chemical: MNXM224 @@ -9986,6 +10777,7 @@ - formula: C9H23N3O - charge: 2 - annotation: !!omap + - bigg.metabolite: N1aspmd - chebi: CHEBI:58324 - kegg.compound: C00612 - metanetx.chemical: MNXM501 @@ -9997,6 +10789,7 @@ - formula: C12H31N4O - charge: 3 - annotation: !!omap + - bigg.metabolite: N1sprm - chebi: CHEBI:58101 - kegg.compound: C02567 - metanetx.chemical: MNXM600 @@ -10008,6 +10801,7 @@ - formula: C7H14N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: acorn - chebi: CHEBI:16543 - kegg.compound: C00437 - metanetx.chemical: MNXM817 @@ -10019,17 +10813,19 @@ - formula: C7H11N3O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: NPmehis - chebi: CHEBI:27596 - kegg.compound: C01152 - - metanetx.chemical: MNXM3309 + - metanetx.chemical: MNXM722872 - sbo: SBO:0000247 - !!omap - id: s_1184 - name: N,N'-diacetylchitobiosyldiphosphodolichol - compartment: c - - formula: C36H64N2O17P2 - - charge: 0 + - formula: C36H62N2O17P2 + - charge: -2 - annotation: !!omap + - bigg.metabolite: chito2pdol - chebi: CHEBI:12427 - kegg.compound: C04537 - metanetx.chemical: MNXM63078 @@ -10038,21 +10834,21 @@ - id: s_1185 - name: N,N'-diformyldityrosine - compartment: c - - formula: C20H20N2O8 - - charge: 0 + - formula: C20H22N2O8 + - charge: -2 - annotation: !!omap - chebi: CHEBI:50611 - - metanetx.chemical: MNXM63081 + - metanetx.chemical: MNXM147516 - sbo: SBO:0000247 - !!omap - id: s_1186 - name: N,N'-diformyldityrosine - compartment: e - - formula: C20H20N2O8 - - charge: 0 + - formula: C20H22N2O8 + - charge: -2 - annotation: !!omap - chebi: CHEBI:50611 - - metanetx.chemical: MNXM63081 + - metanetx.chemical: MNXM147516 - sbo: SBO:0000247 - !!omap - id: s_1187 @@ -10061,6 +10857,7 @@ - formula: C12H13NO9P - charge: -3 - annotation: !!omap + - bigg.metabolite: pran - chebi: CHEBI:18277 - kegg.compound: C04302 - metanetx.chemical: MNXM1489 @@ -10072,6 +10869,7 @@ - formula: C12H20N2O9PS - charge: -3 - annotation: !!omap + - bigg.metabolite: 4ppcys - chebi: CHEBI:59458 - kegg.compound: C04352 - metanetx.chemical: MNXM483 @@ -10080,9 +10878,10 @@ - id: s_1189 - name: N-acetyl-alpha-D-glucosamine 1-phosphate - compartment: c - - formula: C8H16NO9P - - charge: 0 + - formula: C8H14NO9P + - charge: -2 - annotation: !!omap + - bigg.metabolite: acgal1p - chebi: CHEBI:16446 - kegg.compound: C04501 - metanetx.chemical: MNXM340 @@ -10094,6 +10893,7 @@ - formula: C8H14NO9P - charge: -2 - annotation: !!omap + - bigg.metabolite: acgam6p - chebi: CHEBI:57513 - kegg.compound: C00357 - metanetx.chemical: MNXM63556 @@ -10105,6 +10905,7 @@ - formula: C7H9NO8P - charge: -3 - annotation: !!omap + - bigg.metabolite: acg5p - chebi: CHEBI:57936 - kegg.compound: C04133 - metanetx.chemical: MNXM1384 @@ -10116,6 +10917,7 @@ - formula: C7H9NO5 - charge: -2 - annotation: !!omap + - bigg.metabolite: acglu - chebi: CHEBI:44337 - kegg.compound: C00624 - metanetx.chemical: MNXM730 @@ -10127,6 +10929,7 @@ - formula: C6H15N2O - charge: 1 - annotation: !!omap + - bigg.metabolite: aprut - chebi: CHEBI:58263 - kegg.compound: C02714 - metanetx.chemical: MNXM1153 @@ -10138,6 +10941,7 @@ - formula: C5H6N2O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: cbasp - chebi: CHEBI:32814 - kegg.compound: C00438 - metanetx.chemical: MNXM465 @@ -10149,6 +10953,7 @@ - formula: C11H12N2O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: Lfmkynr - chebi: CHEBI:30249 - kegg.compound: C02700 - metanetx.chemical: MNXM1288 @@ -10157,9 +10962,10 @@ - id: s_1196 - name: N-formyl-L-tyrosine - compartment: c - - formula: C10H11NO4 - - charge: 0 + - formula: C10H10NO4 + - charge: -1 - annotation: !!omap + - bigg.metabolite: Nfortyr - chebi: CHEBI:50603 - metanetx.chemical: MNXM63755 - sbo: SBO:0000247 @@ -10170,6 +10976,7 @@ - formula: C21H26N7O14P2 - charge: -1 - annotation: !!omap + - bigg.metabolite: nad - chebi: CHEBI:57540 - kegg.compound: C00003 - metanetx.chemical: MNXM8 @@ -10181,6 +10988,7 @@ - formula: C21H26N7O14P2 - charge: -1 - annotation: !!omap + - bigg.metabolite: nad - chebi: CHEBI:57540 - kegg.compound: C00003 - metanetx.chemical: MNXM8 @@ -10192,6 +11000,7 @@ - formula: C21H26N7O14P2 - charge: -1 - annotation: !!omap + - bigg.metabolite: nad - chebi: CHEBI:57540 - kegg.compound: C00003 - metanetx.chemical: MNXM8 @@ -10203,6 +11012,7 @@ - formula: C21H26N7O14P2 - charge: -1 - annotation: !!omap + - bigg.metabolite: nad - chebi: CHEBI:57540 - kegg.compound: C00003 - metanetx.chemical: MNXM8 @@ -10214,6 +11024,7 @@ - formula: C21H26N7O14P2 - charge: -1 - annotation: !!omap + - bigg.metabolite: nad - chebi: CHEBI:57540 - kegg.compound: C00003 - metanetx.chemical: MNXM8 @@ -10225,6 +11036,7 @@ - formula: C21H27N7O14P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: nadh - chebi: CHEBI:57945 - kegg.compound: C00004 - metanetx.chemical: MNXM10 @@ -10236,6 +11048,7 @@ - formula: C21H27N7O14P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: nadh - chebi: CHEBI:57945 - kegg.compound: C00004 - metanetx.chemical: MNXM10 @@ -10247,6 +11060,7 @@ - formula: C21H27N7O14P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: nadh - chebi: CHEBI:57945 - kegg.compound: C00004 - metanetx.chemical: MNXM10 @@ -10258,6 +11072,7 @@ - formula: C21H27N7O14P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: nadh - chebi: CHEBI:57945 - kegg.compound: C00004 - metanetx.chemical: MNXM10 @@ -10269,6 +11084,7 @@ - formula: C21H25N7O17P3 - charge: -3 - annotation: !!omap + - bigg.metabolite: nadp - chebi: CHEBI:58349 - kegg.compound: C00006 - metanetx.chemical: MNXM5 @@ -10280,6 +11096,7 @@ - formula: C21H25N7O17P3 - charge: -3 - annotation: !!omap + - bigg.metabolite: nadp - chebi: CHEBI:58349 - kegg.compound: C00006 - metanetx.chemical: MNXM5 @@ -10291,6 +11108,7 @@ - formula: C21H25N7O17P3 - charge: -3 - annotation: !!omap + - bigg.metabolite: nadp - chebi: CHEBI:58349 - kegg.compound: C00006 - metanetx.chemical: MNXM5 @@ -10302,6 +11120,7 @@ - formula: C21H25N7O17P3 - charge: -3 - annotation: !!omap + - bigg.metabolite: nadp - chebi: CHEBI:58349 - kegg.compound: C00006 - metanetx.chemical: MNXM5 @@ -10313,6 +11132,7 @@ - formula: C21H26N7O17P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: nadph - chebi: CHEBI:57783 - kegg.compound: C00005 - metanetx.chemical: MNXM6 @@ -10324,6 +11144,7 @@ - formula: C21H26N7O17P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: nadph - chebi: CHEBI:57783 - kegg.compound: C00005 - metanetx.chemical: MNXM6 @@ -10335,6 +11156,7 @@ - formula: C21H26N7O17P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: nadph - chebi: CHEBI:57783 - kegg.compound: C00005 - metanetx.chemical: MNXM6 @@ -10346,6 +11168,7 @@ - formula: C21H26N7O17P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: nadph - chebi: CHEBI:57783 - kegg.compound: C00005 - metanetx.chemical: MNXM6 @@ -10357,6 +11180,7 @@ - formula: C6H6N2O - charge: 0 - annotation: !!omap + - bigg.metabolite: ncam - chebi: CHEBI:17154 - kegg.compound: C00153 - metanetx.chemical: MNXM216 @@ -10368,6 +11192,7 @@ - formula: C6H6N2O - charge: 0 - annotation: !!omap + - bigg.metabolite: ncam - chebi: CHEBI:17154 - kegg.compound: C00153 - metanetx.chemical: MNXM216 @@ -10379,6 +11204,7 @@ - formula: C11H15N2O5 - charge: 1 - annotation: !!omap + - bigg.metabolite: rnam - chebi: CHEBI:15927 - kegg.compound: C03150 - metanetx.chemical: MNXM1115 @@ -10390,6 +11216,7 @@ - formula: C6H4NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: nac - chebi: CHEBI:32544 - kegg.compound: C00253 - metanetx.chemical: MNXM274 @@ -10401,6 +11228,7 @@ - formula: C6H4NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: nac - chebi: CHEBI:32544 - kegg.compound: C00253 - metanetx.chemical: MNXM274 @@ -10412,6 +11240,7 @@ - formula: C6H4NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: nac - chebi: CHEBI:32544 - kegg.compound: C00253 - metanetx.chemical: MNXM274 @@ -10423,6 +11252,7 @@ - formula: C11H12NO9P - charge: -2 - annotation: !!omap + - bigg.metabolite: nicrnt - chebi: CHEBI:57502 - kegg.compound: C01185 - metanetx.chemical: MNXM194 @@ -10434,6 +11264,7 @@ - formula: C11H12NO9P - charge: -2 - annotation: !!omap + - bigg.metabolite: nicrnt - chebi: CHEBI:57502 - kegg.compound: C01185 - metanetx.chemical: MNXM194 @@ -10445,6 +11276,7 @@ - formula: C11H14N2O8P - charge: -1 - annotation: !!omap + - bigg.metabolite: nmn - chebi: CHEBI:14649 - kegg.compound: C00455 - metanetx.chemical: MNXM355 @@ -10456,6 +11288,7 @@ - formula: C11H14N2O8P - charge: -1 - annotation: !!omap + - bigg.metabolite: nmn - chebi: CHEBI:14649 - kegg.compound: C00455 - metanetx.chemical: MNXM355 @@ -10467,6 +11300,7 @@ - formula: C11H14N2O8P - charge: -1 - annotation: !!omap + - bigg.metabolite: nmn - chebi: CHEBI:14649 - kegg.compound: C00455 - metanetx.chemical: MNXM355 @@ -10478,6 +11312,7 @@ - formula: C11H14N2O8P - charge: -1 - annotation: !!omap + - bigg.metabolite: nmn - chebi: CHEBI:14649 - kegg.compound: C00455 - metanetx.chemical: MNXM355 @@ -10486,8 +11321,8 @@ - id: s_1229 - name: nonadecaprenyl diphosphate - compartment: lp - - formula: C95H156O7P2 - - charge: 0 + - formula: C95H153O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53034 - metanetx.chemical: MNXM64863 @@ -10496,8 +11331,8 @@ - id: s_1230 - name: nonaprenyl 4-hydroxybenzoate - compartment: c - - formula: C52H78O3 - - charge: 0 + - formula: C52H77O3 + - charge: -1 - annotation: !!omap - chebi: CHEBI:18162 - kegg.compound: C03885 @@ -10507,8 +11342,8 @@ - id: s_1231 - name: nonaprenyl diphosphate - compartment: c - - formula: C45H76O7P2 - - charge: 0 + - formula: C45H73O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53044 - kegg.compound: C04145 @@ -10518,8 +11353,8 @@ - id: s_1232 - name: nonaprenyl diphosphate - compartment: lp - - formula: C45H76O7P2 - - charge: 0 + - formula: C45H73O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53044 - kegg.compound: C04145 @@ -10532,6 +11367,7 @@ - formula: C6H11NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: achms - chebi: CHEBI:16288 - kegg.compound: C01077 - metanetx.chemical: MNXM699 @@ -10543,6 +11379,7 @@ - formula: C5H9NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: acser - chebi: CHEBI:17981 - kegg.compound: C00979 - metanetx.chemical: MNXM418 @@ -10554,6 +11391,7 @@ - formula: C9H17NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: acrn - chebi: CHEBI:57589 - kegg.compound: C02571 - metanetx.chemical: MNXM1028 @@ -10565,6 +11403,7 @@ - formula: C9H17NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: acrn - chebi: CHEBI:57589 - kegg.compound: C02571 - metanetx.chemical: MNXM1028 @@ -10576,6 +11415,7 @@ - formula: C9H17NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: acrn - chebi: CHEBI:57589 - kegg.compound: C02571 - metanetx.chemical: MNXM1028 @@ -10587,6 +11427,7 @@ - formula: C4H8NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: phom - chebi: CHEBI:57590 - kegg.compound: C01102 - metanetx.chemical: MNXM1334 @@ -10598,6 +11439,7 @@ - formula: C2H7NO4P - charge: -1 - annotation: !!omap + - bigg.metabolite: ethamp - chebi: CHEBI:58190 - kegg.compound: C00346 - metanetx.chemical: MNXM187 @@ -10609,6 +11451,7 @@ - formula: C2H7NO4P - charge: -1 - annotation: !!omap + - bigg.metabolite: ethamp - chebi: CHEBI:58190 - kegg.compound: C00346 - metanetx.chemical: MNXM187 @@ -10620,6 +11463,7 @@ - formula: C8H12NO6 - charge: -1 - annotation: !!omap + - bigg.metabolite: suchms - chebi: CHEBI:57661 - kegg.compound: C01118 - metanetx.chemical: MNXM820 @@ -10628,8 +11472,8 @@ - id: s_1246 - name: octadecaprenyl diphosphate - compartment: lp - - formula: C90H148O7P2 - - charge: 0 + - formula: C90H145O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53035 - metanetx.chemical: MNXM65303 @@ -10641,6 +11485,7 @@ - formula: C8H15O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: octa - chebi: CHEBI:25646 - kegg.compound: C06423 - metanetx.chemical: MNXM750 @@ -10652,6 +11497,7 @@ - formula: C8H15O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: octa - chebi: CHEBI:25646 - kegg.compound: C06423 - metanetx.chemical: MNXM750 @@ -10663,6 +11509,7 @@ - formula: C8H15O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: octa - chebi: CHEBI:25646 - kegg.compound: C06423 - metanetx.chemical: MNXM750 @@ -10685,6 +11532,7 @@ - formula: C29H46N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: occoa - chebi: CHEBI:57386 - kegg.compound: C01944 - metanetx.chemical: MNXM342 @@ -10693,9 +11541,10 @@ - id: s_1259 - name: octaprenyl diphosphate - compartment: lp - - formula: C40H68O7P2 - - charge: 0 + - formula: C40H65O7P2 + - charge: -3 - annotation: !!omap + - bigg.metabolite: octdp - chebi: CHEBI:53045 - kegg.compound: C04146 - metanetx.chemical: MNXM811 @@ -10707,6 +11556,7 @@ - formula: C18H33O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdcea - chebi: CHEBI:30823 - kegg.compound: C00712 - metanetx.chemical: MNXM306 @@ -10718,6 +11568,7 @@ - formula: C39H64N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ocdce9coa - chebi: CHEBI:57387 - kegg.compound: C00510 - metanetx.chemical: MNXM686 @@ -10729,6 +11580,7 @@ - formula: C39H64N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ocdce9coa - chebi: CHEBI:57387 - kegg.compound: C00510 - metanetx.chemical: MNXM686 @@ -10740,6 +11592,7 @@ - formula: C5H13N2O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: orn - chebi: CHEBI:46912 - kegg.compound: C01602 - metanetx.chemical: MNXM89689 @@ -10751,6 +11604,7 @@ - formula: C5H13N2O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: orn - chebi: CHEBI:46912 - kegg.compound: C01602 - metanetx.chemical: MNXM89689 @@ -10762,6 +11616,7 @@ - formula: C5H13N2O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: orn - chebi: CHEBI:46912 - kegg.compound: C01602 - metanetx.chemical: MNXM89689 @@ -10773,6 +11628,7 @@ - formula: C5H3N2O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: orot - chebi: CHEBI:30839 - kegg.compound: C00295 - metanetx.chemical: MNXM235 @@ -10784,6 +11640,7 @@ - formula: C10H10N2O11P - charge: -3 - annotation: !!omap + - bigg.metabolite: orot5p - chebi: CHEBI:57538 - kegg.compound: C01103 - metanetx.chemical: MNXM519 @@ -10795,6 +11652,7 @@ - formula: C4H2O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: oaa - chebi: CHEBI:16452 - kegg.compound: C00036 - metanetx.chemical: MNXM46 @@ -10806,6 +11664,7 @@ - formula: C4H2O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: oaa - chebi: CHEBI:16452 - kegg.compound: C00036 - metanetx.chemical: MNXM46 @@ -10817,6 +11676,7 @@ - formula: C4H2O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: oaa - chebi: CHEBI:16452 - kegg.compound: C00036 - metanetx.chemical: MNXM46 @@ -10828,6 +11688,7 @@ - formula: C4H2O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: oaa - chebi: CHEBI:16452 - kegg.compound: C00036 - metanetx.chemical: MNXM46 @@ -10839,6 +11700,7 @@ - formula: O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: o2 - chebi: CHEBI:15379 - kegg.compound: C00007 - metanetx.chemical: MNXM4 @@ -10850,6 +11712,7 @@ - formula: O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: o2 - chebi: CHEBI:15379 - kegg.compound: C00007 - metanetx.chemical: MNXM4 @@ -10861,6 +11724,7 @@ - formula: O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: o2 - chebi: CHEBI:15379 - kegg.compound: C00007 - metanetx.chemical: MNXM4 @@ -10872,6 +11736,7 @@ - formula: O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: o2 - chebi: CHEBI:15379 - kegg.compound: C00007 - metanetx.chemical: MNXM4 @@ -10883,6 +11748,7 @@ - formula: O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: o2 - chebi: CHEBI:15379 - kegg.compound: C00007 - metanetx.chemical: MNXM4 @@ -10894,6 +11760,7 @@ - formula: C20H24N10O19P4 - charge: -4 - annotation: !!omap + - bigg.metabolite: ap4a - chebi: CHEBI:58141 - kegg.compound: C01260 - metanetx.chemical: MNXM1089 @@ -10905,6 +11772,7 @@ - formula: C20H24N10O21P4 - charge: -4 - annotation: !!omap + - bigg.metabolite: gp4g - chebi: CHEBI:57553 - kegg.compound: C01261 - metanetx.chemical: MNXM1582 @@ -10913,9 +11781,10 @@ - id: s_1284 - name: P1-(5'-adenosyl),P4-(5'-guanosyl) tetraphosphate - compartment: c - - formula: C20H28N10O20P4 - - charge: 0 + - formula: C20H24N10O20P4 + - charge: -4 - annotation: !!omap + - bigg.metabolite: ap4g - chebi: CHEBI:52968 - metanetx.chemical: MNXM66180 - sbo: SBO:0000247 @@ -10926,6 +11795,7 @@ - formula: C16H31O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdca - chebi: CHEBI:7896 - kegg.compound: C00249 - metanetx.chemical: MNXM108 @@ -10937,6 +11807,7 @@ - formula: C16H31O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdca - chebi: CHEBI:7896 - kegg.compound: C00249 - metanetx.chemical: MNXM108 @@ -10948,6 +11819,7 @@ - formula: C16H31O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdca - chebi: CHEBI:7896 - kegg.compound: C00249 - metanetx.chemical: MNXM108 @@ -10959,6 +11831,7 @@ - formula: C16H29O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdcea - chebi: CHEBI:32372 - kegg.compound: C08362 - metanetx.chemical: MNXM162245 @@ -10970,6 +11843,7 @@ - formula: C16H29O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdcea - chebi: CHEBI:32372 - kegg.compound: C08362 - metanetx.chemical: MNXM162245 @@ -10981,6 +11855,7 @@ - formula: C16H29O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdcea - chebi: CHEBI:32372 - kegg.compound: C08362 - metanetx.chemical: MNXM162245 @@ -10992,6 +11867,7 @@ - formula: C37H62N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: pmtcoa - chebi: CHEBI:57379 - kegg.compound: C00154 - metanetx.chemical: MNXM88 @@ -11003,6 +11879,7 @@ - formula: C37H62N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: pmtcoa - chebi: CHEBI:57379 - kegg.compound: C00154 - metanetx.chemical: MNXM88 @@ -11014,6 +11891,7 @@ - formula: C37H62N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: pmtcoa - chebi: CHEBI:57379 - kegg.compound: C00154 - metanetx.chemical: MNXM88 @@ -11025,6 +11903,7 @@ - formula: C11H21N2O7PS - charge: -2 - annotation: !!omap + - bigg.metabolite: pan4p - chebi: CHEBI:47942 - kegg.compound: C01134 - metanetx.chemical: MNXM373 @@ -11036,6 +11915,7 @@ - formula: C11H21N2O7PS - charge: -2 - annotation: !!omap + - bigg.metabolite: pan4p - chebi: CHEBI:47942 - kegg.compound: C01134 - metanetx.chemical: MNXM373 @@ -11044,9 +11924,10 @@ - id: s_1309 - name: pectin - compartment: e - - formula: C6H8O6 + - formula: C6H7O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: pectin - chebi: CHEBI:17309 - kegg.compound: C00714 - metanetx.chemical: MNXM107600 @@ -11055,8 +11936,8 @@ - id: s_1310 - name: pentadecaprenyl diphosphate - compartment: lp - - formula: C75H124O7P2 - - charge: 0 + - formula: C75H121O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53038 - metanetx.chemical: MNXM73155 @@ -11065,9 +11946,10 @@ - id: s_1311 - name: pentaprenyl diphosphate - compartment: c - - formula: C25H44O7P2 - - charge: 0 + - formula: C25H41O7P2 + - charge: -3 - annotation: !!omap + - bigg.metabolite: pendp - chebi: CHEBI:53048 - kegg.compound: C04217 - metanetx.chemical: MNXM2210 @@ -11076,9 +11958,10 @@ - id: s_1312 - name: pentaprenyl diphosphate - compartment: lp - - formula: C25H44O7P2 - - charge: 0 + - formula: C25H41O7P2 + - charge: -3 - annotation: !!omap + - bigg.metabolite: pendp - chebi: CHEBI:53048 - kegg.compound: C04217 - metanetx.chemical: MNXM2210 @@ -11087,9 +11970,10 @@ - id: s_1313 - name: pentaprenyl diphosphate - compartment: m - - formula: C25H44O7P2 - - charge: 0 + - formula: C25H41O7P2 + - charge: -3 - annotation: !!omap + - bigg.metabolite: pendp - chebi: CHEBI:53048 - kegg.compound: C04217 - metanetx.chemical: MNXM2210 @@ -11098,9 +11982,10 @@ - id: s_1314 - name: Phe-tRNA(Phe) - compartment: c - - formula: C9H10NOR - - charge: 0 + - formula: C9H11NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: phetrna - chebi: CHEBI:29153 - kegg.compound: C03511 - metanetx.chemical: MNXM89802 @@ -11109,9 +11994,10 @@ - id: s_1315 - name: Phe-tRNA(Phe) - compartment: m - - formula: C9H10NOR - - charge: 0 + - formula: C9H11NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: phetrna - chebi: CHEBI:29153 - kegg.compound: C03511 - metanetx.chemical: MNXM89802 @@ -11123,6 +12009,7 @@ - formula: C10H12O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pheac - chebi: CHEBI:31988 - kegg.compound: C12303 - metanetx.chemical: MNXM12629 @@ -11134,6 +12021,7 @@ - formula: C10H12O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pheac - chebi: CHEBI:31988 - kegg.compound: C12303 - metanetx.chemical: MNXM12629 @@ -11145,6 +12033,7 @@ - formula: C8H8O - charge: 0 - annotation: !!omap + - bigg.metabolite: pacald - chebi: CHEBI:16424 - kegg.compound: C00601 - metanetx.chemical: MNXM473 @@ -11156,6 +12045,7 @@ - formula: C8H8O - charge: 0 - annotation: !!omap + - bigg.metabolite: pacald - chebi: CHEBI:16424 - kegg.compound: C00601 - metanetx.chemical: MNXM473 @@ -11167,6 +12057,7 @@ - formula: C8H8O - charge: 0 - annotation: !!omap + - bigg.metabolite: pacald - chebi: CHEBI:16424 - kegg.compound: C00601 - metanetx.chemical: MNXM473 @@ -11178,6 +12069,7 @@ - formula: C8H7O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: pac - chebi: CHEBI:18401 - kegg.compound: C07086 - metanetx.chemical: MNXM497 @@ -11189,6 +12081,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -11200,6 +12093,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -11211,6 +12105,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -11222,6 +12117,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -11233,6 +12129,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -11244,6 +12141,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -11255,6 +12153,7 @@ - formula: C6H10NO6P - charge: 0 - annotation: !!omap + - bigg.metabolite: ps_cho - chebi: CHEBI:18303 - kegg.compound: C02737 - metanetx.chemical: MNXM221 @@ -11266,6 +12165,7 @@ - formula: C8H16NO3P - charge: 1 - annotation: !!omap + - bigg.metabolite: pchol_cho - chebi: CHEBI:49183 - kegg.compound: C00157 - metanetx.chemical: MNXM96952 @@ -11277,6 +12177,7 @@ - formula: C5H10NO4P - charge: 0 - annotation: !!omap + - bigg.metabolite: pe_hs - chebi: CHEBI:16038 - kegg.compound: C00350 - metanetx.chemical: MNXM115 @@ -11288,6 +12189,7 @@ - formula: C5H10NO4P - charge: 0 - annotation: !!omap + - bigg.metabolite: pe_hs - chebi: CHEBI:16038 - kegg.compound: C00350 - metanetx.chemical: MNXM115 @@ -11299,6 +12201,7 @@ - formula: C3H2O6P - charge: -3 - annotation: !!omap + - bigg.metabolite: pep - chebi: CHEBI:58702 - kegg.compound: C00074 - metanetx.chemical: MNXM73 @@ -11310,6 +12213,7 @@ - formula: C3H2O6P - charge: -3 - annotation: !!omap + - bigg.metabolite: pep - chebi: CHEBI:58702 - kegg.compound: C00074 - metanetx.chemical: MNXM73 @@ -11318,9 +12222,10 @@ - id: s_1364 - name: phosphoribosyl-carboxy-aminoimidazole - compartment: c - - formula: C9H11N3O9P - - charge: -3 + - formula: C9H12N3O9P + - charge: -2 - annotation: !!omap + - bigg.metabolite: 5aizc - chebi: CHEBI:58564 - kegg.compound: C04751 - metanetx.chemical: MNXM507 @@ -11332,6 +12237,7 @@ - formula: C10H13N4O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: fprica - chebi: CHEBI:58467 - kegg.compound: C04734 - metanetx.chemical: MNXM456 @@ -11340,9 +12246,10 @@ - id: s_1366 - name: phytosphingosine - compartment: er - - formula: C18H39NO3 - - charge: 0 + - formula: C18H40NO3 + - charge: 1 - annotation: !!omap + - bigg.metabolite: psphings - chebi: CHEBI:46961 - kegg.compound: C12144 - metanetx.chemical: MNXM914 @@ -11351,9 +12258,10 @@ - id: s_1367 - name: phytosphingosine 1-phosphate - compartment: er - - formula: C18H40NO6P - - charge: 0 + - formula: C18H39NO6P + - charge: -1 - annotation: !!omap + - bigg.metabolite: psph1p - chebi: CHEBI:46970 - metanetx.chemical: MNXM3337 - sbo: SBO:0000247 @@ -11364,6 +12272,7 @@ - formula: C28H41N7O19P3S - charge: -5 - annotation: !!omap + - bigg.metabolite: pmcoa - chebi: CHEBI:57360 - kegg.compound: C01063 - metanetx.chemical: MNXM951 @@ -11386,6 +12295,7 @@ - formula: C10H13N2O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: ppbng - chebi: CHEBI:58126 - kegg.compound: C00931 - metanetx.chemical: MNXM554 @@ -11397,6 +12307,7 @@ - formula: K - charge: 0 - annotation: !!omap + - bigg.metabolite: k - chebi: CHEBI:26216 - kegg.compound: C00238 - metanetx.chemical: MNXM77881 @@ -11408,6 +12319,7 @@ - formula: K - charge: 0 - annotation: !!omap + - bigg.metabolite: k - chebi: CHEBI:26216 - kegg.compound: C00238 - metanetx.chemical: MNXM77881 @@ -11419,6 +12331,7 @@ - formula: C42H41N4O16 - charge: -7 - annotation: !!omap + - bigg.metabolite: dscl - chebi: CHEBI:58827 - kegg.compound: C02463 - metanetx.chemical: MNXM672 @@ -11430,6 +12343,7 @@ - formula: C5H9O7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: dmpp - chebi: CHEBI:57623 - kegg.compound: C00235 - metanetx.chemical: MNXM132 @@ -11441,6 +12355,7 @@ - formula: C10H8O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: pphn - chebi: CHEBI:29934 - kegg.compound: C00254 - metanetx.chemical: MNXM503 @@ -11452,6 +12367,7 @@ - formula: C40H38N4O17 - charge: -8 - annotation: !!omap + - bigg.metabolite: hmbil - chebi: CHEBI:57845 - kegg.compound: C01024 - metanetx.chemical: MNXM547 @@ -11460,9 +12376,10 @@ - id: s_1379 - name: Pro-tRNA(Pro) - compartment: c - - formula: C5H8NOR - - charge: 0 + - formula: C5H9NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: protrna - chebi: CHEBI:29154 - kegg.compound: C02702 - metanetx.chemical: MNXM247 @@ -11474,6 +12391,7 @@ - formula: C24H36N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ppcoa - chebi: CHEBI:57392 - kegg.compound: C00100 - metanetx.chemical: MNXM86 @@ -11485,6 +12403,7 @@ - formula: C34H32N4O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: ppp9 - chebi: CHEBI:36159 - kegg.compound: C02191 - metanetx.chemical: MNXM346 @@ -11496,6 +12415,7 @@ - formula: C34H38N4O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: pppg9 - chebi: CHEBI:57307 - kegg.compound: C01079 - metanetx.chemical: MNXM351 @@ -11507,6 +12427,7 @@ - formula: C34H38N4O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: pppg9 - chebi: CHEBI:57307 - kegg.compound: C01079 - metanetx.chemical: MNXM351 @@ -11518,6 +12439,7 @@ - formula: C5H8O14P3 - charge: -5 - annotation: !!omap + - bigg.metabolite: prpp - chebi: CHEBI:58017 - kegg.compound: C00119 - metanetx.chemical: MNXM91 @@ -11529,6 +12451,7 @@ - formula: C5H8O14P3 - charge: -5 - annotation: !!omap + - bigg.metabolite: prpp - chebi: CHEBI:58017 - kegg.compound: C00119 - metanetx.chemical: MNXM91 @@ -11551,6 +12474,7 @@ - formula: C4H14N2 - charge: 2 - annotation: !!omap + - bigg.metabolite: ptrc - chebi: CHEBI:326268 - kegg.compound: C00134 - metanetx.chemical: MNXM118 @@ -11562,6 +12486,7 @@ - formula: C4H14N2 - charge: 2 - annotation: !!omap + - bigg.metabolite: ptrc - chebi: CHEBI:326268 - kegg.compound: C00134 - metanetx.chemical: MNXM118 @@ -11573,6 +12498,7 @@ - formula: C4H14N2 - charge: 2 - annotation: !!omap + - bigg.metabolite: ptrc - chebi: CHEBI:326268 - kegg.compound: C00134 - metanetx.chemical: MNXM118 @@ -11584,6 +12510,7 @@ - formula: C8H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: pydx - chebi: CHEBI:17310 - kegg.compound: C00250 - metanetx.chemical: MNXM311 @@ -11595,6 +12522,7 @@ - formula: C8H8NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: pydx5p - chebi: CHEBI:597326 - kegg.compound: C00018 - metanetx.chemical: MNXM161 @@ -11606,6 +12534,7 @@ - formula: C8H13N2O2 - charge: 1 - annotation: !!omap + - bigg.metabolite: pydam - chebi: CHEBI:57761 - kegg.compound: C00534 - metanetx.chemical: MNXM548 @@ -11617,6 +12546,7 @@ - formula: C8H12N2O5P - charge: -1 - annotation: !!omap + - bigg.metabolite: pyam5p - chebi: CHEBI:58451 - kegg.compound: C00647 - metanetx.chemical: MNXM366 @@ -11628,6 +12558,7 @@ - formula: C8H11NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: pydxn - chebi: CHEBI:16709 - kegg.compound: C00314 - metanetx.chemical: MNXM419 @@ -11639,6 +12570,7 @@ - formula: C8H11NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: pydxn - chebi: CHEBI:16709 - kegg.compound: C00314 - metanetx.chemical: MNXM419 @@ -11650,6 +12582,7 @@ - formula: C8H10NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: pdx5p - chebi: CHEBI:58589 - kegg.compound: C00627 - metanetx.chemical: MNXM454 @@ -11661,6 +12594,7 @@ - formula: C3H3O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: pyr - chebi: CHEBI:15361 - kegg.compound: C00022 - metanetx.chemical: MNXM23 @@ -11672,6 +12606,7 @@ - formula: C3H3O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: pyr - chebi: CHEBI:15361 - kegg.compound: C00022 - metanetx.chemical: MNXM23 @@ -11683,6 +12618,7 @@ - formula: C3H3O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: pyr - chebi: CHEBI:15361 - kegg.compound: C00022 - metanetx.chemical: MNXM23 @@ -11694,6 +12630,7 @@ - formula: C7H3NO4 - charge: -2 - annotation: !!omap + - bigg.metabolite: quln - chebi: CHEBI:29959 - kegg.compound: C03722 - metanetx.chemical: MNXM555 @@ -11705,6 +12642,7 @@ - formula: C7H3NO4 - charge: -2 - annotation: !!omap + - bigg.metabolite: quln - chebi: CHEBI:29959 - kegg.compound: C03722 - metanetx.chemical: MNXM555 @@ -11716,6 +12654,7 @@ - formula: C17H19N4O6 - charge: -1 - annotation: !!omap + - bigg.metabolite: ribflv - chebi: CHEBI:57986 - kegg.compound: C00255 - metanetx.chemical: MNXM270 @@ -11727,6 +12666,7 @@ - formula: C17H19N4O6 - charge: -1 - annotation: !!omap + - bigg.metabolite: ribflv - chebi: CHEBI:57986 - kegg.compound: C00255 - metanetx.chemical: MNXM270 @@ -11738,6 +12678,7 @@ - formula: C17H19N4O6 - charge: -1 - annotation: !!omap + - bigg.metabolite: ribflv - chebi: CHEBI:57986 - kegg.compound: C00255 - metanetx.chemical: MNXM270 @@ -11746,9 +12687,10 @@ - id: s_1408 - name: ribose-5-phosphate - compartment: c - - formula: C5H11O8P - - charge: 0 + - formula: C5H9O8P + - charge: -2 - annotation: !!omap + - bigg.metabolite: r5p - chebi: CHEBI:18189 - kegg.compound: C03736 - metanetx.chemical: MNXM15900 @@ -11757,9 +12699,10 @@ - id: s_1409 - name: S(8)-aminomethyldihydrolipoamide - compartment: m - - formula: C9H20N2OS2 - - charge: 0 + - formula: C9H21N2OS2 + - charge: 1 - annotation: !!omap + - bigg.metabolite: alpam - chebi: CHEBI:50622 - metanetx.chemical: MNXM81220 - sbo: SBO:0000247 @@ -11767,9 +12710,10 @@ - id: s_1410 - name: S(8)-aminomethyldihydrolipoylprotein - compartment: m - - formula: C9H18NOS2R + - formula: C9H19N2OS2R - charge: 0 - annotation: !!omap + - bigg.metabolite: alpro - chebi: CHEBI:16882 - kegg.compound: C01242 - metanetx.chemical: MNXM81221 @@ -11778,9 +12722,10 @@ - id: s_1411 - name: S(8)-succinyldihydrolipoamide - compartment: m - - formula: C12H21NO4S2 - - charge: 0 + - formula: C12H20NO4S2 + - charge: -1 - annotation: !!omap + - bigg.metabolite: sdhlam - chebi: CHEBI:17432 - kegg.compound: C01169 - metanetx.chemical: MNXM3710 @@ -11792,6 +12737,7 @@ - formula: C15H19N5O6S - charge: 0 - annotation: !!omap + - bigg.metabolite: amob - chebi: CHEBI:16490 - kegg.compound: C04425 - metanetx.chemical: MNXM3090 @@ -11803,6 +12749,7 @@ - formula: C14H20N6O5S - charge: 0 - annotation: !!omap + - bigg.metabolite: ahcys - chebi: CHEBI:16680 - kegg.compound: C00021 - metanetx.chemical: MNXM19 @@ -11814,6 +12761,7 @@ - formula: C14H20N6O5S - charge: 0 - annotation: !!omap + - bigg.metabolite: ahcys - chebi: CHEBI:16680 - kegg.compound: C00021 - metanetx.chemical: MNXM19 @@ -11825,6 +12773,7 @@ - formula: C15H23N6O5S - charge: 1 - annotation: !!omap + - bigg.metabolite: amet - chebi: CHEBI:15414 - kegg.compound: C00019 - metanetx.chemical: MNXM16 @@ -11836,6 +12785,7 @@ - formula: C15H23N6O5S - charge: 1 - annotation: !!omap + - bigg.metabolite: amet - chebi: CHEBI:15414 - kegg.compound: C00019 - metanetx.chemical: MNXM16 @@ -11847,6 +12797,7 @@ - formula: C15H23N6O5S - charge: 1 - annotation: !!omap + - bigg.metabolite: amet - chebi: CHEBI:15414 - kegg.compound: C00019 - metanetx.chemical: MNXM16 @@ -11858,6 +12809,7 @@ - formula: C14H24N6O3S - charge: 2 - annotation: !!omap + - bigg.metabolite: ametam - chebi: CHEBI:57443 - kegg.compound: C01137 - metanetx.chemical: MNXM321 @@ -11869,6 +12821,7 @@ - formula: C11H16N3O7S - charge: -1 - annotation: !!omap + - bigg.metabolite: Sfglutth - chebi: CHEBI:57688 - kegg.compound: C01031 - metanetx.chemical: MNXM952 @@ -11880,6 +12833,7 @@ - formula: C6H11O7PS - charge: -2 - annotation: !!omap + - bigg.metabolite: 5mdr1p - chebi: CHEBI:58533 - kegg.compound: C04188 - metanetx.chemical: MNXM407 @@ -11891,6 +12845,7 @@ - formula: C6H11O7PS - charge: -2 - annotation: !!omap + - bigg.metabolite: 5mdru1p - chebi: CHEBI:58548 - kegg.compound: C04582 - metanetx.chemical: MNXM522 @@ -11902,6 +12857,7 @@ - formula: C6H14NO2S - charge: 1 - annotation: !!omap + - bigg.metabolite: mmet - chebi: CHEBI:17728 - kegg.compound: C03172 - metanetx.chemical: MNXM1119 @@ -11913,6 +12869,7 @@ - formula: C6H14NO2S - charge: 1 - annotation: !!omap + - bigg.metabolite: mmet - chebi: CHEBI:17728 - kegg.compound: C03172 - metanetx.chemical: MNXM1119 @@ -11924,6 +12881,7 @@ - formula: C7H12O13P2 - charge: -4 - annotation: !!omap + - bigg.metabolite: s17bp - chebi: CHEBI:58335 - kegg.compound: C00447 - metanetx.chemical: MNXM1294 @@ -11935,6 +12893,7 @@ - formula: C7H13O10P - charge: -2 - annotation: !!omap + - bigg.metabolite: s7p - chebi: CHEBI:57483 - kegg.compound: C05382 - metanetx.chemical: MNXM271 @@ -11943,9 +12902,10 @@ - id: s_1428 - name: Ser-tRNA(Ser) - compartment: c - - formula: C3H6NO2R - - charge: 0 + - formula: C3H7NO2R + - charge: 1 - annotation: !!omap + - bigg.metabolite: sertrna - chebi: CHEBI:29162 - kegg.compound: C02553 - metanetx.chemical: MNXM165150 @@ -11957,6 +12917,7 @@ - formula: C7H9O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: skm - chebi: CHEBI:36208 - kegg.compound: C00493 - metanetx.chemical: MNXM602 @@ -11968,6 +12929,7 @@ - formula: C42H36FeN4O16 - charge: -8 - annotation: !!omap + - bigg.metabolite: sheme - chebi: CHEBI:60052 - kegg.compound: C00748 - metanetx.chemical: MNXM82173 @@ -11979,6 +12941,7 @@ - formula: C42H38N4O16 - charge: -8 - annotation: !!omap + - bigg.metabolite: scl - chebi: CHEBI:58351 - kegg.compound: C05778 - metanetx.chemical: MNXM863 @@ -11990,6 +12953,7 @@ - formula: C8H20NO6P - charge: 0 - annotation: !!omap + - bigg.metabolite: g3pc - chebi: CHEBI:16870 - kegg.compound: C00670 - metanetx.chemical: MNXM367 @@ -12001,6 +12965,7 @@ - formula: C8H20NO6P - charge: 0 - annotation: !!omap + - bigg.metabolite: g3pc - chebi: CHEBI:16870 - kegg.compound: C00670 - metanetx.chemical: MNXM367 @@ -12012,6 +12977,7 @@ - formula: C8H20NO6P - charge: 0 - annotation: !!omap + - bigg.metabolite: g3pc - chebi: CHEBI:16870 - kegg.compound: C00670 - metanetx.chemical: MNXM367 @@ -12023,6 +12989,7 @@ - formula: Na - charge: 0 - annotation: !!omap + - bigg.metabolite: na1 - chebi: CHEBI:26708 - kegg.compound: C01330 - metanetx.chemical: MNXM82334 @@ -12034,6 +13001,7 @@ - formula: Na - charge: 0 - annotation: !!omap + - bigg.metabolite: na1 - chebi: CHEBI:26708 - kegg.compound: C01330 - metanetx.chemical: MNXM82334 @@ -12045,6 +13013,7 @@ - formula: C7H22N3 - charge: 3 - annotation: !!omap + - bigg.metabolite: spmd - chebi: CHEBI:57834 - kegg.compound: C00315 - metanetx.chemical: MNXM124 @@ -12056,6 +13025,7 @@ - formula: C7H22N3 - charge: 3 - annotation: !!omap + - bigg.metabolite: spmd - chebi: CHEBI:57834 - kegg.compound: C00315 - metanetx.chemical: MNXM124 @@ -12067,6 +13037,7 @@ - formula: C7H22N3 - charge: 3 - annotation: !!omap + - bigg.metabolite: spmd - chebi: CHEBI:57834 - kegg.compound: C00315 - metanetx.chemical: MNXM124 @@ -12078,6 +13049,7 @@ - formula: C10H30N4 - charge: 4 - annotation: !!omap + - bigg.metabolite: sprm - chebi: CHEBI:45725 - kegg.compound: C00750 - metanetx.chemical: MNXM408 @@ -12089,6 +13061,7 @@ - formula: C10H30N4 - charge: 4 - annotation: !!omap + - bigg.metabolite: sprm - chebi: CHEBI:45725 - kegg.compound: C00750 - metanetx.chemical: MNXM408 @@ -12100,6 +13073,7 @@ - formula: C10H30N4 - charge: 4 - annotation: !!omap + - bigg.metabolite: sprm - chebi: CHEBI:45725 - kegg.compound: C00750 - metanetx.chemical: MNXM408 @@ -12111,6 +13085,7 @@ - formula: C18H40NO2 - charge: 1 - annotation: !!omap + - bigg.metabolite: sphgn - chebi: CHEBI:57817 - kegg.compound: C00836 - metanetx.chemical: MNXM302 @@ -12122,6 +13097,7 @@ - formula: C18H39NO5P - charge: -1 - annotation: !!omap + - bigg.metabolite: sph1p - chebi: CHEBI:57939 - kegg.compound: C01120 - metanetx.chemical: MNXM487 @@ -12133,6 +13109,7 @@ - formula: C30H50 - charge: 0 - annotation: !!omap + - bigg.metabolite: sql - chebi: CHEBI:15440 - kegg.compound: C00751 - metanetx.chemical: MNXM292 @@ -12144,6 +13121,7 @@ - formula: C30H50 - charge: 0 - annotation: !!omap + - bigg.metabolite: sql - chebi: CHEBI:15440 - kegg.compound: C00751 - metanetx.chemical: MNXM292 @@ -12155,6 +13133,7 @@ - formula: C18H35O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdca - chebi: CHEBI:25629 - kegg.compound: C01530 - metanetx.chemical: MNXM236 @@ -12166,6 +13145,7 @@ - formula: C18H35O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdca - chebi: CHEBI:25629 - kegg.compound: C01530 - metanetx.chemical: MNXM236 @@ -12177,6 +13157,7 @@ - formula: C18H35O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdca - chebi: CHEBI:25629 - kegg.compound: C01530 - metanetx.chemical: MNXM236 @@ -12188,6 +13169,7 @@ - formula: C39H66N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: stcoa - chebi: CHEBI:57394 - kegg.compound: C00412 - metanetx.chemical: MNXM272 @@ -12199,6 +13181,7 @@ - formula: C39H66N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: stcoa - chebi: CHEBI:57394 - kegg.compound: C00412 - metanetx.chemical: MNXM272 @@ -12210,6 +13193,7 @@ - formula: C4H4O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: succ - chebi: CHEBI:30031 - kegg.compound: C00042 - metanetx.chemical: MNXM25 @@ -12221,6 +13205,7 @@ - formula: C4H4O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: succ - chebi: CHEBI:30031 - kegg.compound: C00042 - metanetx.chemical: MNXM25 @@ -12232,6 +13217,7 @@ - formula: C4H4O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: succ - chebi: CHEBI:30031 - kegg.compound: C00042 - metanetx.chemical: MNXM25 @@ -12243,6 +13229,7 @@ - formula: C4H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: sucsal - chebi: CHEBI:57706 - kegg.compound: C00232 - metanetx.chemical: MNXM172 @@ -12254,6 +13241,7 @@ - formula: C25H35N7O19P3S - charge: -5 - annotation: !!omap + - bigg.metabolite: succoa - chebi: CHEBI:57292 - kegg.compound: C00091 - metanetx.chemical: MNXM92 @@ -12265,6 +13253,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: sucr - chebi: CHEBI:17992 - kegg.compound: C00089 - metanetx.chemical: MNXM167 @@ -12276,6 +13265,7 @@ - formula: O4S - charge: -2 - annotation: !!omap + - bigg.metabolite: so4 - chebi: CHEBI:16189 - kegg.compound: C00059 - metanetx.chemical: MNXM58 @@ -12287,6 +13277,7 @@ - formula: O4S - charge: -2 - annotation: !!omap + - bigg.metabolite: so4 - chebi: CHEBI:16189 - kegg.compound: C00059 - metanetx.chemical: MNXM58 @@ -12295,9 +13286,10 @@ - id: s_1469 - name: sulphite - compartment: c - - formula: HO3S - - charge: -1 + - formula: O3S + - charge: -2 - annotation: !!omap + - bigg.metabolite: so3 - chebi: CHEBI:17137 - kegg.compound: C11481 - metanetx.chemical: MNXM105630 @@ -12306,9 +13298,10 @@ - id: s_1470 - name: sulphite - compartment: e - - formula: HO3S - - charge: -1 + - formula: O3S + - charge: -2 - annotation: !!omap + - bigg.metabolite: so3 - chebi: CHEBI:17137 - kegg.compound: C11481 - metanetx.chemical: MNXM105630 @@ -12320,6 +13313,7 @@ - formula: C2H7NO3S - charge: 0 - annotation: !!omap + - bigg.metabolite: taur - chebi: CHEBI:15891 - kegg.compound: C00245 - metanetx.chemical: MNXM282 @@ -12331,6 +13325,7 @@ - formula: C2H7NO3S - charge: 0 - annotation: !!omap + - bigg.metabolite: taur - chebi: CHEBI:15891 - kegg.compound: C00245 - metanetx.chemical: MNXM282 @@ -12342,6 +13337,7 @@ - formula: C26H44NO7S - charge: -1 - annotation: !!omap + - bigg.metabolite: tchola - chebi: CHEBI:36257 - kegg.compound: C05122 - metanetx.chemical: MNXM2288 @@ -12353,6 +13349,7 @@ - formula: C26H44NO7S - charge: -1 - annotation: !!omap + - bigg.metabolite: tchola - chebi: CHEBI:36257 - kegg.compound: C05122 - metanetx.chemical: MNXM2288 @@ -12361,9 +13358,10 @@ - id: s_1475 - name: TDP - compartment: c - - formula: C12H18N4O7P2S - - charge: 0 + - formula: C12H16N4O7P2S + - charge: -2 - annotation: !!omap + - bigg.metabolite: thmpp - chebi: CHEBI:45931 - kegg.compound: C00068 - metanetx.chemical: MNXM256 @@ -12372,9 +13370,10 @@ - id: s_1476 - name: TDP - compartment: e - - formula: C12H18N4O7P2S - - charge: 0 + - formula: C12H16N4O7P2S + - charge: -2 - annotation: !!omap + - bigg.metabolite: thmpp - chebi: CHEBI:45931 - kegg.compound: C00068 - metanetx.chemical: MNXM256 @@ -12383,9 +13382,10 @@ - id: s_1477 - name: TDP - compartment: m - - formula: C12H18N4O7P2S - - charge: 0 + - formula: C12H16N4O7P2S + - charge: -2 - annotation: !!omap + - bigg.metabolite: thmpp - chebi: CHEBI:45931 - kegg.compound: C00068 - metanetx.chemical: MNXM256 @@ -12394,9 +13394,10 @@ - id: s_1479 - name: tetracosanoyl-CoA - compartment: c - - formula: C45H82N7O17P3S - - charge: 0 + - formula: C45H78N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: ttccoa - chebi: CHEBI:52974 - kegg.compound: C16529 - metanetx.chemical: MNXM1504 @@ -12405,9 +13406,10 @@ - id: s_1480 - name: tetracosanoyl-CoA - compartment: er - - formula: C45H82N7O17P3S - - charge: 0 + - formula: C45H78N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: ttccoa - chebi: CHEBI:52974 - kegg.compound: C16529 - metanetx.chemical: MNXM1504 @@ -12416,9 +13418,10 @@ - id: s_1482 - name: tetracosanoyl-CoA - compartment: p - - formula: C45H82N7O17P3S - - charge: 0 + - formula: C45H78N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: ttccoa - chebi: CHEBI:52974 - kegg.compound: C16529 - metanetx.chemical: MNXM1504 @@ -12427,8 +13430,8 @@ - id: s_1483 - name: tetradecaprenyl diphosphate - compartment: lp - - formula: C70H116O7P2 - - charge: 0 + - formula: C70H113O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53039 - metanetx.chemical: MNXM83846 @@ -12440,6 +13443,7 @@ - formula: C29H33N9O12 - charge: -4 - annotation: !!omap + - bigg.metabolite: hpglu - chebi: CHEBI:58140 - kegg.compound: C04144 - metanetx.chemical: MNXM2563 @@ -12448,9 +13452,10 @@ - id: s_1487 - name: THF - compartment: c - - formula: C19H23N7O6 - - charge: 0 + - formula: C19H21N7O6 + - charge: -2 - annotation: !!omap + - bigg.metabolite: thf - chebi: CHEBI:20506 - kegg.compound: C00101 - metanetx.chemical: MNXM79 @@ -12459,9 +13464,10 @@ - id: s_1488 - name: THF - compartment: m - - formula: C19H23N7O6 - - charge: 0 + - formula: C19H21N7O6 + - charge: -2 - annotation: !!omap + - bigg.metabolite: thf - chebi: CHEBI:20506 - kegg.compound: C00101 - metanetx.chemical: MNXM79 @@ -12473,6 +13479,7 @@ - formula: C12H17N4OS - charge: 1 - annotation: !!omap + - bigg.metabolite: thm - chebi: CHEBI:18385 - kegg.compound: C00378 - metanetx.chemical: MNXM322 @@ -12484,6 +13491,7 @@ - formula: C12H17N4OS - charge: 1 - annotation: !!omap + - bigg.metabolite: thm - chebi: CHEBI:18385 - kegg.compound: C00378 - metanetx.chemical: MNXM322 @@ -12492,9 +13500,10 @@ - id: s_1491 - name: Thr-tRNA(Thr) - compartment: c - - formula: C4H8NO2R - - charge: 0 + - formula: C4H9NO2R + - charge: 1 - annotation: !!omap + - bigg.metabolite: thrtrna - chebi: CHEBI:29163 - kegg.compound: C02992 - metanetx.chemical: MNXM89895 @@ -12503,9 +13512,10 @@ - id: s_1492 - name: Thr-tRNA(Thr) - compartment: m - - formula: C4H8NO2R - - charge: 0 + - formula: C4H9NO2R + - charge: 1 - annotation: !!omap + - bigg.metabolite: thrtrna - chebi: CHEBI:29163 - kegg.compound: C02992 - metanetx.chemical: MNXM89895 @@ -12517,6 +13527,7 @@ - formula: C10H14N2O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: thymd - chebi: CHEBI:17748 - kegg.compound: C00214 - metanetx.chemical: MNXM420 @@ -12528,6 +13539,7 @@ - formula: C10H14N2O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: thymd - chebi: CHEBI:17748 - kegg.compound: C00214 - metanetx.chemical: MNXM420 @@ -12536,9 +13548,10 @@ - id: s_1497 - name: TMP - compartment: c - - formula: C12H18N4O4PS - - charge: 1 + - formula: C12H16N4O4PS + - charge: -1 - annotation: !!omap + - bigg.metabolite: thmmp - chebi: CHEBI:9533 - kegg.compound: C01081 - metanetx.chemical: MNXM662 @@ -12547,9 +13560,10 @@ - id: s_1498 - name: TMP - compartment: e - - formula: C12H18N4O4PS - - charge: 1 + - formula: C12H16N4O4PS + - charge: -1 - annotation: !!omap + - bigg.metabolite: thmmp - chebi: CHEBI:9533 - kegg.compound: C01081 - metanetx.chemical: MNXM662 @@ -12561,6 +13575,7 @@ - formula: C6H3O6 - charge: -3 - annotation: !!omap + - bigg.metabolite: acon_T - chebi: CHEBI:15708 - kegg.compound: C02341 - metanetx.chemical: MNXM1388 @@ -12572,6 +13587,7 @@ - formula: C6H3O6 - charge: -3 - annotation: !!omap + - bigg.metabolite: acon_T - chebi: CHEBI:15708 - kegg.compound: C02341 - metanetx.chemical: MNXM1388 @@ -12583,6 +13599,8 @@ - formula: C31H48N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: dc2coa + - chebi: CHEBI:61406 - kegg.compound: C05275 - metanetx.chemical: MNXM580 - sbo: SBO:0000247 @@ -12593,6 +13611,8 @@ - formula: C33H52N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: dd2coa + - chebi: CHEBI:57330 - kegg.compound: C03221 - metanetx.chemical: MNXM642 - sbo: SBO:0000247 @@ -12600,9 +13620,10 @@ - id: s_1513 - name: trans-hexacos-2-enoyl-CoA - compartment: p - - formula: C47H84N7O17P3S - - charge: 0 + - formula: C47H80N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: hxc2coa - chebi: CHEBI:52975 - metanetx.chemical: MNXM114303 - sbo: SBO:0000247 @@ -12610,9 +13631,10 @@ - id: s_1516 - name: trans-octadec-2-enoyl-CoA - compartment: p - - formula: C39H68N7O17P3S - - charge: 0 + - formula: C39H64N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: od2coa - chebi: CHEBI:50570 - kegg.compound: C16218 - metanetx.chemical: MNXM954 @@ -12624,6 +13646,7 @@ - formula: C35H56N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: td2coa - chebi: CHEBI:61405 - kegg.compound: C05273 - metanetx.chemical: MNXM654 @@ -12635,6 +13658,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: tre - chebi: CHEBI:16551 - kegg.compound: C01083 - metanetx.chemical: MNXM198 @@ -12646,6 +13670,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: tre - chebi: CHEBI:16551 - kegg.compound: C01083 - metanetx.chemical: MNXM198 @@ -12657,6 +13682,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: tre - chebi: CHEBI:16551 - kegg.compound: C01083 - metanetx.chemical: MNXM198 @@ -12665,8 +13691,8 @@ - id: s_1523 - name: tridecaprenyl diphosphate - compartment: lp - - formula: C65H108O7P2 - - charge: 0 + - formula: C65H105O7P2 + - charge: -3 - annotation: !!omap - chebi: CHEBI:53040 - metanetx.chemical: MNXM5721 @@ -12678,6 +13704,7 @@ - formula: C3H2 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag_cho - chebi: CHEBI:17855 - kegg.compound: C00422 - metanetx.chemical: MNXM248 @@ -12697,9 +13724,10 @@ - id: s_1527 - name: Trp-tRNA(Trp) - compartment: c - - formula: C11H11N2OR - - charge: 0 + - formula: C11H12N2OR + - charge: 1 - annotation: !!omap + - bigg.metabolite: trptrna - chebi: CHEBI:29159 - kegg.compound: C03512 - metanetx.chemical: MNXM89804 @@ -12708,9 +13736,10 @@ - id: s_1528 - name: Trp-tRNA(Trp) - compartment: m - - formula: C11H11N2OR - - charge: 0 + - formula: C11H12N2OR + - charge: 1 - annotation: !!omap + - bigg.metabolite: trptrna - chebi: CHEBI:29159 - kegg.compound: C03512 - metanetx.chemical: MNXM89804 @@ -12722,6 +13751,7 @@ - formula: C10H11NO - charge: 0 - annotation: !!omap + - bigg.metabolite: ind3eth - chebi: CHEBI:17890 - kegg.compound: C00955 - metanetx.chemical: MNXM1686 @@ -12733,6 +13763,7 @@ - formula: C10H11NO - charge: 0 - annotation: !!omap + - bigg.metabolite: ind3eth - chebi: CHEBI:17890 - kegg.compound: C00955 - metanetx.chemical: MNXM1686 @@ -12744,6 +13775,7 @@ - formula: C10H11NO - charge: 0 - annotation: !!omap + - bigg.metabolite: ind3eth - chebi: CHEBI:17890 - kegg.compound: C00955 - metanetx.chemical: MNXM1686 @@ -12755,6 +13787,7 @@ - formula: C12H16N4O10P3S - charge: -3 - annotation: !!omap + - bigg.metabolite: thmtp - chebi: CHEBI:58938 - kegg.compound: C03028 - metanetx.chemical: MNXM1341 @@ -12763,9 +13796,10 @@ - id: s_1533 - name: Tyr-tRNA(Tyr) - compartment: c - - formula: C9H10NO2R - - charge: 0 + - formula: C9H11NO2R + - charge: 1 - annotation: !!omap + - bigg.metabolite: tyrtrna - chebi: CHEBI:29161 - kegg.compound: C02839 - metanetx.chemical: MNXM89822 @@ -12774,9 +13808,10 @@ - id: s_1534 - name: Tyr-tRNA(Tyr) - compartment: m - - formula: C9H10NO2R - - charge: 0 + - formula: C9H11NO2R + - charge: 1 - annotation: !!omap + - bigg.metabolite: tyrtrna - chebi: CHEBI:29161 - kegg.compound: C02839 - metanetx.chemical: MNXM89822 @@ -12799,6 +13834,7 @@ - formula: C39H58O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: q6 - chebi: CHEBI:52971 - kegg.compound: C17568 - metanetx.chemical: MNXM1783 @@ -12810,6 +13846,7 @@ - formula: C9H11N2O12P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: udp - chebi: CHEBI:58223 - kegg.compound: C00015 - metanetx.chemical: MNXM17 @@ -12821,6 +13858,7 @@ - formula: C9H11N2O12P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: udp - chebi: CHEBI:58223 - kegg.compound: C00015 - metanetx.chemical: MNXM17 @@ -12832,6 +13870,7 @@ - formula: C9H11N2O12P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: udp - chebi: CHEBI:58223 - kegg.compound: C00015 - metanetx.chemical: MNXM17 @@ -12843,6 +13882,7 @@ - formula: C15H22N2O17P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: udpgal - chebi: CHEBI:58439 - kegg.compound: C00052 - metanetx.chemical: MNXM89795 @@ -12854,6 +13894,7 @@ - formula: C15H22N2O17P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: udpgal - chebi: CHEBI:58439 - kegg.compound: C00052 - metanetx.chemical: MNXM89795 @@ -12865,9 +13906,10 @@ - formula: C15H22N2O17P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: udpg - chebi: CHEBI:58367 - kegg.compound: C00029 - - metanetx.chemical: MNXM52 + - metanetx.chemical: MNXM722710 - sbo: SBO:0000247 - !!omap - id: s_1544 @@ -12876,6 +13918,7 @@ - formula: C17H25N3O17P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: uacgam - chebi: CHEBI:57705 - kegg.compound: C00043 - metanetx.chemical: MNXM47 @@ -12887,6 +13930,7 @@ - formula: C9H11N2O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: ump - chebi: CHEBI:57865 - kegg.compound: C00105 - metanetx.chemical: MNXM80 @@ -12898,6 +13942,7 @@ - formula: C9H11N2O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: ump - chebi: CHEBI:57865 - kegg.compound: C00105 - metanetx.chemical: MNXM80 @@ -12909,6 +13954,7 @@ - formula: C9H11N2O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: ump - chebi: CHEBI:57865 - kegg.compound: C00105 - metanetx.chemical: MNXM80 @@ -12920,6 +13966,7 @@ - formula: C9H11N2O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: ump - chebi: CHEBI:57865 - kegg.compound: C00105 - metanetx.chemical: MNXM80 @@ -12928,9 +13975,10 @@ - id: s_1549 - name: undecaprenyl diphosphate - compartment: lp - - formula: C55H92O7P2 - - charge: 0 + - formula: C55H89O7P2 + - charge: -3 - annotation: !!omap + - bigg.metabolite: udcpdp - chebi: CHEBI:53042 - kegg.compound: C03543 - metanetx.chemical: MNXM5043 @@ -12942,6 +13990,7 @@ - formula: C4H4N2O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ura - chebi: CHEBI:17568 - kegg.compound: C00106 - metanetx.chemical: MNXM158 @@ -12953,6 +14002,7 @@ - formula: C4H4N2O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ura - chebi: CHEBI:17568 - kegg.compound: C00106 - metanetx.chemical: MNXM158 @@ -12964,6 +14014,7 @@ - formula: CH4N2O - charge: 0 - annotation: !!omap + - bigg.metabolite: urea - chebi: CHEBI:16199 - kegg.compound: C00086 - metanetx.chemical: MNXM117 @@ -12975,6 +14026,7 @@ - formula: CH4N2O - charge: 0 - annotation: !!omap + - bigg.metabolite: urea - chebi: CHEBI:16199 - kegg.compound: C00086 - metanetx.chemical: MNXM117 @@ -12986,6 +14038,7 @@ - formula: C2H3N2O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: allphn - chebi: CHEBI:15832 - kegg.compound: C01010 - metanetx.chemical: MNXM1122 @@ -12994,9 +14047,10 @@ - id: s_1555 - name: ureidoglycolic acid - compartment: c - - formula: C3H6N2O4 - - charge: 0 + - formula: C3H5N2O4 + - charge: -1 - annotation: !!omap + - bigg.metabolite: urdglyc - chebi: CHEBI:49050 - kegg.compound: C05241 - metanetx.chemical: MNXM490 @@ -13008,6 +14062,7 @@ - formula: C9H12N2O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: uri - chebi: CHEBI:16704 - kegg.compound: C00299 - metanetx.chemical: MNXM288 @@ -13019,6 +14074,7 @@ - formula: C9H12N2O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: uri - chebi: CHEBI:16704 - kegg.compound: C00299 - metanetx.chemical: MNXM288 @@ -13030,6 +14086,7 @@ - formula: C40H36N4O16 - charge: -8 - annotation: !!omap + - bigg.metabolite: uppg3 - chebi: CHEBI:57308 - kegg.compound: C01051 - metanetx.chemical: MNXM414 @@ -13041,6 +14098,7 @@ - formula: C9H11N2O15P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: utp - chebi: CHEBI:46398 - kegg.compound: C00075 - metanetx.chemical: MNXM121 @@ -13052,6 +14110,7 @@ - formula: C9H11N2O15P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: utp - chebi: CHEBI:46398 - kegg.compound: C00075 - metanetx.chemical: MNXM121 @@ -13060,9 +14119,10 @@ - id: s_1561 - name: Val-tRNA(Val) - compartment: c - - formula: C5H10NOR - - charge: 0 + - formula: C5H11NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: valtrna - chebi: CHEBI:29164 - kegg.compound: C02554 - metanetx.chemical: MNXM90110 @@ -13071,9 +14131,10 @@ - id: s_1562 - name: Val-tRNA(Val) - compartment: m - - formula: C5H10NOR - - charge: 0 + - formula: C5H11NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: valtrna - chebi: CHEBI:29164 - kegg.compound: C02554 - metanetx.chemical: MNXM90110 @@ -13085,6 +14146,7 @@ - formula: C10H12N4O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: xtsn - chebi: CHEBI:18107 - kegg.compound: C01762 - metanetx.chemical: MNXM687 @@ -13096,6 +14158,7 @@ - formula: C10H12N4O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: xtsn - chebi: CHEBI:18107 - kegg.compound: C01762 - metanetx.chemical: MNXM687 @@ -13107,6 +14170,7 @@ - formula: C10H11N4O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: xmp - chebi: CHEBI:57464 - kegg.compound: C00655 - metanetx.chemical: MNXM298 @@ -13118,6 +14182,7 @@ - formula: C5H12O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: xylt - chebi: CHEBI:17151 - kegg.compound: C00379 - metanetx.chemical: MNXM510 @@ -13129,6 +14194,7 @@ - formula: C5H12O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: xylt - chebi: CHEBI:17151 - kegg.compound: C00379 - metanetx.chemical: MNXM510 @@ -13140,6 +14206,7 @@ - formula: C27H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: zymst - chebi: CHEBI:18252 - kegg.compound: C05437 - metanetx.chemical: MNXM574 @@ -13151,6 +14218,7 @@ - formula: C27H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: zymst - chebi: CHEBI:18252 - kegg.compound: C05437 - metanetx.chemical: MNXM574 @@ -13162,6 +14230,7 @@ - formula: C27H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: zymst - chebi: CHEBI:18252 - kegg.compound: C05437 - metanetx.chemical: MNXM574 @@ -13173,6 +14242,7 @@ - formula: C27H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: zymst - chebi: CHEBI:18252 - kegg.compound: C05437 - metanetx.chemical: MNXM574 @@ -13184,6 +14254,7 @@ - formula: C28H46O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: M00963 - chebi: CHEBI:52388 - metanetx.chemical: MNXM89469 - sbo: SBO:0000247 @@ -13194,6 +14265,7 @@ - formula: C28H44O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: M00959 - chebi: CHEBI:52615 - metanetx.chemical: MNXM89470 - sbo: SBO:0000247 @@ -13201,8 +14273,8 @@ - id: s_1578 - name: zymosterol intermediate 1c - compartment: c - - formula: C29H46O2 - - charge: 0 + - formula: C28H43O3 + - charge: -1 - annotation: !!omap - chebi: CHEBI:52389 - metanetx.chemical: MNXM89471 @@ -13214,6 +14286,7 @@ - formula: C27H42O - charge: 0 - annotation: !!omap + - bigg.metabolite: M01067 - chebi: CHEBI:52386 - metanetx.chemical: MNXM2876 - sbo: SBO:0000247 @@ -13221,8 +14294,10 @@ - id: s_1582 - name: tRNA(Ala) - compartment: c - - formula: R + - formula: RH + - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaala - chebi: CHEBI:29170 - kegg.compound: C01635 - metanetx.chemical: MNXM89576 @@ -13231,9 +14306,10 @@ - id: s_1583 - name: tRNA(Arg) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaarg - chebi: CHEBI:29171 - kegg.compound: C01636 - metanetx.chemical: MNXM90751 @@ -13242,9 +14318,10 @@ - id: s_1584 - name: tRNA(Arg) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaarg - chebi: CHEBI:29171 - kegg.compound: C01636 - metanetx.chemical: MNXM90751 @@ -13253,9 +14330,10 @@ - id: s_1585 - name: tRNA(Asn) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaasn - chebi: CHEBI:29172 - kegg.compound: C01637 - metanetx.chemical: MNXM90665 @@ -13264,9 +14342,10 @@ - id: s_1586 - name: tRNA(Asn) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaasn - chebi: CHEBI:29172 - kegg.compound: C01637 - metanetx.chemical: MNXM90665 @@ -13275,9 +14354,10 @@ - id: s_1587 - name: tRNA(Asp) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaasp - chebi: CHEBI:29186 - kegg.compound: C01638 - metanetx.chemical: MNXM90752 @@ -13286,9 +14366,10 @@ - id: s_1588 - name: tRNA(Asp) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaasp - chebi: CHEBI:29186 - kegg.compound: C01638 - metanetx.chemical: MNXM90752 @@ -13297,8 +14378,10 @@ - id: s_1589 - name: tRNA(Cys) - compartment: c - - formula: R + - formula: RH + - charge: 0 - annotation: !!omap + - bigg.metabolite: trnacys - chebi: CHEBI:29167 - kegg.compound: C01639 - metanetx.chemical: MNXM162355 @@ -13307,8 +14390,10 @@ - id: s_1590 - name: tRNA(Gln) - compartment: c - - formula: R + - formula: RH + - charge: 0 - annotation: !!omap + - bigg.metabolite: trnagln - chebi: CHEBI:29168 - kegg.compound: C01640 - metanetx.chemical: MNXM71 @@ -13317,9 +14402,10 @@ - id: s_1591 - name: tRNA(Glu) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaglu - chebi: CHEBI:29175 - kegg.compound: C01641 - metanetx.chemical: MNXM90886 @@ -13328,9 +14414,10 @@ - id: s_1592 - name: tRNA(Glu) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaglu - chebi: CHEBI:29175 - kegg.compound: C01641 - metanetx.chemical: MNXM90886 @@ -13339,8 +14426,10 @@ - id: s_1593 - name: tRNA(Gly) - compartment: c - - formula: R + - formula: RH + - charge: 0 - annotation: !!omap + - bigg.metabolite: trnagly - chebi: CHEBI:29176 - kegg.compound: C01642 - metanetx.chemical: MNXM90340 @@ -13349,9 +14438,10 @@ - id: s_1594 - name: tRNA(His) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnahis - chebi: CHEBI:29178 - kegg.compound: C01643 - metanetx.chemical: MNXM90878 @@ -13360,9 +14450,10 @@ - id: s_1595 - name: tRNA(His) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnahis - chebi: CHEBI:29178 - kegg.compound: C01643 - metanetx.chemical: MNXM90878 @@ -13371,9 +14462,10 @@ - id: s_1596 - name: tRNA(Ile) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaile - chebi: CHEBI:29174 - kegg.compound: C01644 - metanetx.chemical: MNXM90879 @@ -13382,9 +14474,10 @@ - id: s_1597 - name: tRNA(Ile) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaile - chebi: CHEBI:29174 - kegg.compound: C01644 - metanetx.chemical: MNXM90879 @@ -13393,9 +14486,10 @@ - id: s_1598 - name: tRNA(Leu) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaleu - chebi: CHEBI:29169 - kegg.compound: C01645 - metanetx.chemical: MNXM90880 @@ -13404,9 +14498,10 @@ - id: s_1599 - name: tRNA(Leu) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaleu - chebi: CHEBI:29169 - kegg.compound: C01645 - metanetx.chemical: MNXM90880 @@ -13415,9 +14510,10 @@ - id: s_1600 - name: tRNA(Lys) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnalys - chebi: CHEBI:29185 - kegg.compound: C01646 - metanetx.chemical: MNXM90881 @@ -13426,9 +14522,10 @@ - id: s_1601 - name: tRNA(Lys) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnalys - chebi: CHEBI:29185 - kegg.compound: C01646 - metanetx.chemical: MNXM90881 @@ -13437,9 +14534,10 @@ - id: s_1602 - name: tRNA(Met) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnamet - chebi: CHEBI:29173 - kegg.compound: C01647 - metanetx.chemical: MNXM90882 @@ -13448,9 +14546,10 @@ - id: s_1603 - name: tRNA(Met) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnamet - chebi: CHEBI:29173 - kegg.compound: C01647 - metanetx.chemical: MNXM90882 @@ -13459,9 +14558,10 @@ - id: s_1604 - name: tRNA(Phe) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaphe - chebi: CHEBI:29184 - kegg.compound: C01648 - metanetx.chemical: MNXM90753 @@ -13470,9 +14570,10 @@ - id: s_1605 - name: tRNA(Phe) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaphe - chebi: CHEBI:29184 - kegg.compound: C01648 - metanetx.chemical: MNXM90753 @@ -13481,8 +14582,10 @@ - id: s_1606 - name: tRNA(Pro) - compartment: c - - formula: R + - formula: RH + - charge: 0 - annotation: !!omap + - bigg.metabolite: trnapro - chebi: CHEBI:29177 - kegg.compound: C01649 - metanetx.chemical: MNXM90667 @@ -13491,8 +14594,10 @@ - id: s_1607 - name: tRNA(Ser) - compartment: c - - formula: R + - formula: RH + - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaser - chebi: CHEBI:29179 - kegg.compound: C01650 - metanetx.chemical: MNXM91028 @@ -13501,9 +14606,10 @@ - id: s_1608 - name: tRNA(Thr) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnathr - chebi: CHEBI:29180 - kegg.compound: C01651 - metanetx.chemical: MNXM90883 @@ -13512,9 +14618,10 @@ - id: s_1609 - name: tRNA(Thr) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnathr - chebi: CHEBI:29180 - kegg.compound: C01651 - metanetx.chemical: MNXM90883 @@ -13523,9 +14630,10 @@ - id: s_1610 - name: tRNA(Trp) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnatrp - chebi: CHEBI:29181 - kegg.compound: C01652 - metanetx.chemical: MNXM90755 @@ -13534,9 +14642,10 @@ - id: s_1611 - name: tRNA(Trp) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnatrp - chebi: CHEBI:29181 - kegg.compound: C01652 - metanetx.chemical: MNXM90755 @@ -13545,9 +14654,10 @@ - id: s_1612 - name: tRNA(Tyr) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnatyr - chebi: CHEBI:29182 - kegg.compound: C00787 - metanetx.chemical: MNXM90668 @@ -13556,9 +14666,10 @@ - id: s_1613 - name: tRNA(Tyr) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnatyr - chebi: CHEBI:29182 - kegg.compound: C00787 - metanetx.chemical: MNXM90668 @@ -13567,9 +14678,10 @@ - id: s_1614 - name: tRNA(Val) - compartment: c - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaval - chebi: CHEBI:29183 - kegg.compound: C01653 - metanetx.chemical: MNXM90885 @@ -13578,9 +14690,10 @@ - id: s_1615 - name: tRNA(Val) - compartment: m - - formula: R + - formula: RH - charge: 0 - annotation: !!omap + - bigg.metabolite: trnaval - chebi: CHEBI:29183 - kegg.compound: C01653 - metanetx.chemical: MNXM90885 @@ -13589,53 +14702,58 @@ - id: s_1616 - name: TRX1 - compartment: c - - formula: C6H9NO2S2R2 + - formula: C6H10N2O2S2R4 - charge: 0 - annotation: !!omap - - chebi: CHEBI:15967 + - bigg.metabolite: trdrd + - chebi: CHEBI:15033 - kegg.compound: C00342 - - metanetx.chemical: MNXM155 + - metanetx.chemical: MNXM96993 - sbo: SBO:0000247 - !!omap - id: s_1617 - name: TRX1 - compartment: m - - formula: C6H9NO2S2R2 + - formula: C6H10N2O2S2R4 - charge: 0 - annotation: !!omap - - chebi: CHEBI:15967 + - bigg.metabolite: trdrd + - chebi: CHEBI:15033 - kegg.compound: C00342 - - metanetx.chemical: MNXM155 + - metanetx.chemical: MNXM96993 - sbo: SBO:0000247 - !!omap - id: s_1618 - name: TRX1 - compartment: n - - formula: C6H9NO2S2R2 + - formula: C6H10N2O2S2R4 - charge: 0 - annotation: !!omap - - chebi: CHEBI:15967 + - bigg.metabolite: trdrd + - chebi: CHEBI:15033 - kegg.compound: C00342 - - metanetx.chemical: MNXM155 + - metanetx.chemical: MNXM96993 - sbo: SBO:0000247 - !!omap - id: s_1619 - name: TRX1 - compartment: p - - formula: C6H9NO2S2R2 + - formula: C6H10N2O2S2R4 - charge: 0 - annotation: !!omap - - chebi: CHEBI:15967 + - bigg.metabolite: trdrd + - chebi: CHEBI:15033 - kegg.compound: C00342 - - metanetx.chemical: MNXM155 + - metanetx.chemical: MNXM96993 - sbo: SBO:0000247 - !!omap - id: s_1620 - name: TRX1 disulphide - compartment: c - - formula: C6H8N2O2S2R4 - - charge: 0 + - formula: C6H9N2O2S2R4 + - charge: 1 - annotation: !!omap + - bigg.metabolite: trdox - chebi: CHEBI:18191 - kegg.compound: C00343 - metanetx.chemical: MNXM148 @@ -13644,9 +14762,10 @@ - id: s_1621 - name: TRX1 disulphide - compartment: m - - formula: C6H8N2O2S2R4 - - charge: 0 + - formula: C6H9N2O2S2R4 + - charge: 1 - annotation: !!omap + - bigg.metabolite: trdox - chebi: CHEBI:18191 - kegg.compound: C00343 - metanetx.chemical: MNXM148 @@ -13655,9 +14774,10 @@ - id: s_1622 - name: TRX1 disulphide - compartment: n - - formula: C6H8N2O2S2R4 - - charge: 0 + - formula: C6H9N2O2S2R4 + - charge: 1 - annotation: !!omap + - bigg.metabolite: trdox - chebi: CHEBI:18191 - kegg.compound: C00343 - metanetx.chemical: MNXM148 @@ -13666,9 +14786,10 @@ - id: s_1623 - name: TRX1 disulphide - compartment: p - - formula: C6H8N2O2S2R4 - - charge: 0 + - formula: C6H9N2O2S2R4 + - charge: 1 - annotation: !!omap + - bigg.metabolite: trdox - chebi: CHEBI:18191 - kegg.compound: C00343 - metanetx.chemical: MNXM148 @@ -13679,6 +14800,7 @@ - compartment: m - charge: 0 - annotation: !!omap + - bigg.metabolite: ACP - chebi: CHEBI:18359 - kegg.compound: C00229 - metanetx.chemical: MNXM925 @@ -13687,9 +14809,10 @@ - id: s_2763 - name: kynurenic acid - compartment: c - - formula: C10H7NO3 - - charge: 0 + - formula: C10H6NO3 + - charge: -1 - annotation: !!omap + - bigg.metabolite: kynate - chebi: CHEBI:18344 - kegg.compound: C01717 - metanetx.chemical: MNXM1113 @@ -13712,6 +14835,7 @@ - formula: C29H48O - charge: 0 - annotation: !!omap + - bigg.metabolite: 44mzym - chebi: CHEBI:18364 - kegg.compound: C05108 - metanetx.chemical: MNXM913 @@ -13723,6 +14847,7 @@ - formula: C28H42O - charge: 0 - annotation: !!omap + - bigg.metabolite: ergtetrol - chebi: CHEBI:18249 - kegg.compound: C05440 - metanetx.chemical: MNXM1109 @@ -13734,6 +14859,7 @@ - formula: C4H5O2SR - charge: 0 - annotation: !!omap + - bigg.metabolite: actACP - chebi: CHEBI:2393 - kegg.compound: C05744 - metanetx.chemical: MNXM1223 @@ -13756,6 +14882,7 @@ - formula: C6H9O2SR - charge: 0 - annotation: !!omap + - bigg.metabolite: 3ohexACP - chebi: CHEBI:1642 - kegg.compound: C05746 - metanetx.chemical: MNXM25602 @@ -13778,6 +14905,7 @@ - formula: C8H13O2SR - charge: 0 - annotation: !!omap + - bigg.metabolite: 3ooctACP - chebi: CHEBI:1646 - kegg.compound: C05750 - metanetx.chemical: MNXM28031 @@ -13789,6 +14917,7 @@ - formula: C4H7O2SR - charge: 0 - annotation: !!omap + - bigg.metabolite: 3hbutACP - kegg.compound: C04618 - sbo: SBO:0000247 - !!omap @@ -13798,6 +14927,7 @@ - formula: C6H11O2SR - charge: 0 - annotation: !!omap + - bigg.metabolite: 3hhexACP - chebi: CHEBI:326 - kegg.compound: C05747 - metanetx.chemical: MNXM25370 @@ -13806,17 +14936,19 @@ - id: s_2777 - name: 3-hydroxyoctanoyl-ACP - compartment: m - - formula: C18H35O2S + - formula: C8H15O2SR - charge: 0 - annotation: !!omap + - bigg.metabolite: 3hoctaACP - chebi: CHEBI:80387 - kegg.compound: C16220 + - metanetx.chemical: MNXM10033 - sbo: SBO:0000247 - !!omap - id: s_2778 - name: trans-but-2-enoyl-ACP - compartment: m - - formula: C4H5OS + - formula: C4H5OSR - charge: 0 - annotation: !!omap - chebi: CHEBI:132146 @@ -13828,6 +14960,7 @@ - formula: C6H9OSR - charge: 0 - annotation: !!omap + - bigg.metabolite: thex2eACP - chebi: CHEBI:10727 - kegg.compound: C05748 - metanetx.chemical: MNXM24502 @@ -13839,7 +14972,9 @@ - formula: C8H13OSR - charge: 0 - annotation: !!omap + - bigg.metabolite: toct2eACP - kegg.compound: C05751 + - metanetx.chemical: MNXM23766 - sbo: SBO:0000247 - !!omap - id: s_2781 @@ -13848,6 +14983,7 @@ - formula: C33H54N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ddcacoa - chebi: CHEBI:57375 - kegg.compound: C01832 - metanetx.chemical: MNXM363 @@ -13859,6 +14995,7 @@ - formula: C24H33N7O19P3S - charge: -5 - annotation: !!omap + - bigg.metabolite: malcoa - chebi: CHEBI:57384 - kegg.compound: C00083 - metanetx.chemical: MNXM40 @@ -13870,6 +15007,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -13881,6 +15019,7 @@ - formula: CO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: co2 - chebi: CHEBI:16526 - kegg.compound: C00011 - metanetx.chemical: MNXM13 @@ -13892,6 +15031,7 @@ - formula: C21H32N7O16P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: coa - chebi: CHEBI:57287 - kegg.compound: C00010 - metanetx.chemical: MNXM12 @@ -13900,9 +15040,10 @@ - id: s_2786 - name: 3-oxotetradecanoyl-CoA - compartment: erm - - formula: C35H60N7O18P3S - - charge: 0 + - formula: C35H56N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3otdcoa - chebi: CHEBI:28726 - kegg.compound: C05261 - metanetx.chemical: MNXM707 @@ -13914,6 +15055,7 @@ - formula: C35H58N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: tdcoa - chebi: CHEBI:57385 - kegg.compound: C02593 - metanetx.chemical: MNXM224 @@ -13925,6 +15067,7 @@ - formula: C37H60N7O18P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: 3ohdcoa - chebi: CHEBI:57349 - kegg.compound: C05259 - metanetx.chemical: MNXM738 @@ -13936,6 +15079,7 @@ - formula: C37H62N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: pmtcoa - chebi: CHEBI:57379 - kegg.compound: C00154 - metanetx.chemical: MNXM88 @@ -13944,9 +15088,10 @@ - id: s_2790 - name: 3-oxooctadecanoyl-CoA - compartment: erm - - formula: C39H68N7O18P3S - - charge: 0 + - formula: C39H64N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3ohodcoa - chebi: CHEBI:50571 - kegg.compound: C16216 - metanetx.chemical: MNXM513 @@ -13958,6 +15103,7 @@ - formula: C39H66N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: stcoa - chebi: CHEBI:57394 - kegg.compound: C00412 - metanetx.chemical: MNXM272 @@ -13966,9 +15112,10 @@ - id: s_2792 - name: 3-oxoicosanoyl-CoA - compartment: erm - - formula: C41H72N7O18P3S - - charge: 0 + - formula: C41H68N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2251 - chebi: CHEBI:52327 - metanetx.chemical: MNXM36762 - sbo: SBO:0000247 @@ -13976,9 +15123,10 @@ - id: s_2793 - name: icosanoyl-CoA - compartment: erm - - formula: C41H74N7O17P3S - - charge: 0 + - formula: C41H70N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: arachcoa - chebi: CHEBI:15527 - kegg.compound: C02041 - metanetx.chemical: MNXM1429 @@ -13987,9 +15135,10 @@ - id: s_2794 - name: 3-oxodocosanoyl-CoA - compartment: erm - - formula: C43H76N7O18P3S - - charge: 0 + - formula: C43H72N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2250 - chebi: CHEBI:52328 - metanetx.chemical: MNXM36756 - sbo: SBO:0000247 @@ -13997,9 +15146,10 @@ - id: s_2795 - name: docosanoyl-CoA - compartment: erm - - formula: C43H78N7O17P3S - - charge: 0 + - formula: C43H74N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: docoscoa - chebi: CHEBI:65088 - kegg.compound: C16528 - metanetx.chemical: MNXM10780 @@ -14008,9 +15158,10 @@ - id: s_2796 - name: 3-oxotetracosanoyl-CoA - compartment: erm - - formula: C45H80N7O18P3S - - charge: 0 + - formula: C45H76N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2253 - chebi: CHEBI:52329 - metanetx.chemical: MNXM36773 - sbo: SBO:0000247 @@ -14018,9 +15169,10 @@ - id: s_2797 - name: tetracosanoyl-CoA - compartment: erm - - formula: C45H82N7O17P3S - - charge: 0 + - formula: C45H78N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: ttccoa - chebi: CHEBI:52974 - kegg.compound: C16529 - metanetx.chemical: MNXM1504 @@ -14029,9 +15181,10 @@ - id: s_2798 - name: 3-oxohexacosanoyl-CoA - compartment: erm - - formula: C47H84N7O18P3S - - charge: 0 + - formula: C47H80N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3ohxccoa - chebi: CHEBI:52977 - metanetx.chemical: MNXM36758 - sbo: SBO:0000247 @@ -14042,6 +15195,7 @@ - formula: C21H26N7O17P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: nadph - chebi: CHEBI:57783 - kegg.compound: C00005 - metanetx.chemical: MNXM6 @@ -14053,6 +15207,7 @@ - formula: C21H25N7O17P3 - charge: -3 - annotation: !!omap + - bigg.metabolite: nadp - chebi: CHEBI:58349 - kegg.compound: C00006 - metanetx.chemical: MNXM5 @@ -14061,9 +15216,10 @@ - id: s_2801 - name: (S)-3-hydroxytetradecanoyl-CoA - compartment: erm - - formula: C35H62N7O18P3S - - charge: 0 + - formula: C35H58N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3htdcoa - chebi: CHEBI:27466 - kegg.compound: C05260 - metanetx.chemical: MNXM767 @@ -14072,9 +15228,10 @@ - id: s_2802 - name: (S)-3-hydroxypalmitoyl-CoA - compartment: erm - - formula: C37H66N7O18P3S - - charge: 0 + - formula: C37H62N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: 3hhdcoa - chebi: CHEBI:27402 - kegg.compound: C05258 - metanetx.chemical: MNXM825 @@ -14083,9 +15240,10 @@ - id: s_2803 - name: 3-hydroxyoctadecanoyl-CoA - compartment: erm - - formula: C39H70N7O18P3S - - charge: 0 + - formula: C39H66N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2248 - chebi: CHEBI:50583 - kegg.compound: C16217 - metanetx.chemical: MNXM1309 @@ -14094,9 +15252,10 @@ - id: s_2804 - name: 3-hydroxyicosanoyl-CoA - compartment: erm - - formula: C41H74N7O18P3S - - charge: 0 + - formula: C41H70N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2247 - chebi: CHEBI:52324 - metanetx.chemical: MNXM146349 - sbo: SBO:0000247 @@ -14104,9 +15263,10 @@ - id: s_2805 - name: 3-hydroxydocosanoyl-CoA - compartment: erm - - formula: C43H78N7O18P3S - - charge: 0 + - formula: C43H74N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2246 - chebi: CHEBI:52325 - metanetx.chemical: MNXM162568 - sbo: SBO:0000247 @@ -14114,18 +15274,19 @@ - id: s_2806 - name: 3-hydroxytetracosanoyl-CoA - compartment: erm - - formula: C45H82N7O18P3S - - charge: 0 + - formula: C45H78N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2249 - chebi: CHEBI:52326 - - metanetx.chemical: MNXM163185 + - metanetx.chemical: MNXM36558 - sbo: SBO:0000247 - !!omap - id: s_2807 - name: (S)-3-hydroxyhexacosanoyl-CoA - compartment: erm - - formula: C47H86N7O18P3S - - charge: 0 + - formula: C47H82N7O18P3S + - charge: -4 - annotation: !!omap - chebi: CHEBI:52976 - metanetx.chemical: MNXM31741 @@ -14137,6 +15298,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -14148,6 +15310,7 @@ - formula: C35H56N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: td2coa - chebi: CHEBI:61405 - kegg.compound: C05273 - metanetx.chemical: MNXM654 @@ -14156,18 +15319,21 @@ - id: s_2810 - name: trans-hexadec-2-enoyl-CoA - compartment: erm - - formula: C37H64N7O17P3S - - charge: 0 + - formula: C37H60N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: hdd2coa - kegg.compound: C05272 + - metanetx.chemical: MNXM581 - sbo: SBO:0000247 - !!omap - id: s_2811 - name: trans-octadec-2-enoyl-CoA - compartment: erm - - formula: C39H68N7O17P3S - - charge: 0 + - formula: C39H64N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: od2coa - chebi: CHEBI:50570 - kegg.compound: C16218 - metanetx.chemical: MNXM954 @@ -14176,34 +15342,39 @@ - id: s_2812 - name: trans-icos-2-enoyl-CoA - compartment: erm - - formula: C41H72N7O17P3S - - charge: 0 + - formula: C41H68N7O17P3S + - charge: -4 - annotation: !!omap + - metanetx.chemical: MNXM22115 - sbo: SBO:0000247 - !!omap - id: s_2813 - name: trans-docos-2-enoyl-CoA - compartment: erm - - formula: C33H56N7O17P3S - - charge: 0 + - formula: C43H72N7O17P3S + - charge: -4 - annotation: !!omap + - metanetx.chemical: MNXM97615 - sbo: SBO:0000247 - !!omap - id: s_2814 - name: trans-tetracos-2-enoyl-CoA - compartment: erm - - formula: C45H80N7O17P3S - - charge: 0 + - formula: C45H76N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2245 - chebi: CHEBI:75068 + - metanetx.chemical: MNXM97616 - sbo: SBO:0000247 - !!omap - id: s_2815 - name: trans-hexacos-2-enoyl-CoA - compartment: erm - - formula: C47H84N7O17P3S - - charge: 0 + - formula: C47H80N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: hxc2coa - chebi: CHEBI:52975 - metanetx.chemical: MNXM114303 - sbo: SBO:0000247 @@ -14211,9 +15382,10 @@ - id: s_2816 - name: hexacosanoyl-CoA - compartment: erm - - formula: C47H86N7O17P3S - - charge: 0 + - formula: C47H82N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: hexccoa - chebi: CHEBI:52966 - metanetx.chemical: MNXM1190 - sbo: SBO:0000247 @@ -14224,6 +15396,7 @@ - formula: O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: o2 - chebi: CHEBI:15379 - kegg.compound: C00007 - metanetx.chemical: MNXM4 @@ -14235,6 +15408,7 @@ - formula: C21H27N7O14P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: nadh - chebi: CHEBI:57945 - kegg.compound: C00004 - metanetx.chemical: MNXM10 @@ -14246,6 +15420,7 @@ - formula: C37H60N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: hdcoa - chebi: CHEBI:61540 - kegg.compound: C21072 - metanetx.chemical: MNXM781 @@ -14257,6 +15432,7 @@ - formula: C21H26N7O14P2 - charge: -1 - annotation: !!omap + - bigg.metabolite: nad - chebi: CHEBI:57540 - kegg.compound: C00003 - metanetx.chemical: MNXM8 @@ -14268,6 +15444,7 @@ - formula: C39H64N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ocdce9coa - chebi: CHEBI:57387 - kegg.compound: C00510 - metanetx.chemical: MNXM686 @@ -14279,6 +15456,7 @@ - formula: C4H7O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: but - chebi: CHEBI:17968 - kegg.compound: C00246 - metanetx.chemical: MNXM458 @@ -14290,6 +15468,7 @@ - formula: C6H11O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hxa - chebi: CHEBI:17120 - kegg.compound: C01585 - metanetx.chemical: MNXM1653 @@ -14301,6 +15480,7 @@ - formula: C18H33O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdcea - chebi: CHEBI:30823 - kegg.compound: C00712 - metanetx.chemical: MNXM306 @@ -14312,6 +15492,7 @@ - formula: C4H7O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: but - chebi: CHEBI:17968 - kegg.compound: C00246 - metanetx.chemical: MNXM458 @@ -14323,6 +15504,7 @@ - formula: C6H11O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hxa - chebi: CHEBI:17120 - kegg.compound: C01585 - metanetx.chemical: MNXM1653 @@ -14334,6 +15516,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -14345,6 +15528,7 @@ - formula: C12H23O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ddca - chebi: CHEBI:18262 - kegg.compound: C02679 - metanetx.chemical: MNXM402 @@ -14356,6 +15540,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: amp - chebi: CHEBI:456215 - kegg.compound: C00020 - metanetx.chemical: MNXM14 @@ -14367,6 +15552,7 @@ - formula: HO7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ppi - chebi: CHEBI:33019 - kegg.compound: C00013 - metanetx.chemical: MNXM11 @@ -14378,6 +15564,7 @@ - formula: C14H27O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ttdca - chebi: CHEBI:30807 - kegg.compound: C06424 - metanetx.chemical: MNXM314 @@ -14389,6 +15576,7 @@ - formula: C16H31O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdca - chebi: CHEBI:7896 - kegg.compound: C00249 - metanetx.chemical: MNXM108 @@ -14400,6 +15588,7 @@ - formula: C16H29O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdcea - chebi: CHEBI:32372 - kegg.compound: C08362 - metanetx.chemical: MNXM162245 @@ -14411,6 +15600,7 @@ - formula: C18H35O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdca - chebi: CHEBI:25629 - kegg.compound: C01530 - metanetx.chemical: MNXM236 @@ -14422,6 +15612,7 @@ - formula: C18H33O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdcea - chebi: CHEBI:30823 - kegg.compound: C00712 - metanetx.chemical: MNXM306 @@ -14433,6 +15624,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -14444,6 +15636,7 @@ - formula: C12H23O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ddca - chebi: CHEBI:18262 - kegg.compound: C02679 - metanetx.chemical: MNXM402 @@ -14455,6 +15648,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: amp - chebi: CHEBI:456215 - kegg.compound: C00020 - metanetx.chemical: MNXM14 @@ -14466,6 +15660,7 @@ - formula: C33H54N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ddcacoa - chebi: CHEBI:57375 - kegg.compound: C01832 - metanetx.chemical: MNXM363 @@ -14477,6 +15672,7 @@ - formula: C14H27O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ttdca - chebi: CHEBI:30807 - kegg.compound: C06424 - metanetx.chemical: MNXM314 @@ -14488,6 +15684,7 @@ - formula: C35H58N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: tdcoa - chebi: CHEBI:57385 - kegg.compound: C02593 - metanetx.chemical: MNXM224 @@ -14499,6 +15696,7 @@ - formula: C16H31O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdca - chebi: CHEBI:7896 - kegg.compound: C00249 - metanetx.chemical: MNXM108 @@ -14510,6 +15708,7 @@ - formula: C37H62N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: pmtcoa - chebi: CHEBI:57379 - kegg.compound: C00154 - metanetx.chemical: MNXM88 @@ -14521,6 +15720,7 @@ - formula: C16H29O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdcea - chebi: CHEBI:32372 - kegg.compound: C08362 - metanetx.chemical: MNXM162245 @@ -14532,6 +15732,7 @@ - formula: C37H60N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: hdcoa - chebi: CHEBI:61540 - kegg.compound: C21072 - metanetx.chemical: MNXM781 @@ -14543,6 +15744,7 @@ - formula: C18H35O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdca - chebi: CHEBI:25629 - kegg.compound: C01530 - metanetx.chemical: MNXM236 @@ -14554,6 +15756,7 @@ - formula: C39H66N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: stcoa - chebi: CHEBI:57394 - kegg.compound: C00412 - metanetx.chemical: MNXM272 @@ -14565,6 +15768,7 @@ - formula: C18H33O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdcea - chebi: CHEBI:30823 - kegg.compound: C00712 - metanetx.chemical: MNXM306 @@ -14576,6 +15780,7 @@ - formula: C39H64N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ocdce9coa - chebi: CHEBI:57387 - kegg.compound: C00510 - metanetx.chemical: MNXM686 @@ -14587,6 +15792,7 @@ - formula: C37H60N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: hdcoa - chebi: CHEBI:61540 - kegg.compound: C21072 - metanetx.chemical: MNXM781 @@ -14598,6 +15804,7 @@ - formula: C18H33O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdcea - chebi: CHEBI:30823 - kegg.compound: C00712 - metanetx.chemical: MNXM306 @@ -14609,6 +15816,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -14620,6 +15828,7 @@ - formula: C21H32N7O16P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: coa - chebi: CHEBI:57287 - kegg.compound: C00010 - metanetx.chemical: MNXM12 @@ -14631,7 +15840,10 @@ - formula: C20H39O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: arach - chebi: CHEBI:32360 + - kegg.compound: C06425 + - metanetx.chemical: MNXM2976 - sbo: SBO:0000247 - !!omap - id: s_2859 @@ -14640,6 +15852,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: amp - chebi: CHEBI:456215 - kegg.compound: C00020 - metanetx.chemical: MNXM14 @@ -14651,6 +15864,7 @@ - formula: HO7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ppi - chebi: CHEBI:33019 - kegg.compound: C00013 - metanetx.chemical: MNXM11 @@ -14659,9 +15873,10 @@ - id: s_2861 - name: icosanoyl-CoA - compartment: ce - - formula: C41H74N7O17P3S - - charge: 0 + - formula: C41H70N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: arachcoa - chebi: CHEBI:15527 - kegg.compound: C02041 - metanetx.chemical: MNXM1429 @@ -14673,6 +15888,7 @@ - formula: C22H43O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: docosac - chebi: CHEBI:23858 - kegg.compound: C08281 - metanetx.chemical: MNXM7102 @@ -14681,9 +15897,10 @@ - id: s_2863 - name: docosanoyl-CoA - compartment: ce - - formula: C43H78N7O17P3S - - charge: 0 + - formula: C43H74N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: docoscoa - chebi: CHEBI:65088 - kegg.compound: C16528 - metanetx.chemical: MNXM10780 @@ -14695,6 +15912,7 @@ - formula: C24H47O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: lgnc - chebi: CHEBI:31014 - kegg.compound: C08320 - metanetx.chemical: MNXM3297 @@ -14703,9 +15921,10 @@ - id: s_2865 - name: tetracosanoyl-CoA - compartment: ce - - formula: C45H82N7O17P3S - - charge: 0 + - formula: C45H78N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: ttccoa - chebi: CHEBI:52974 - kegg.compound: C16529 - metanetx.chemical: MNXM1504 @@ -14717,6 +15936,7 @@ - formula: C26H51O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hexc - chebi: CHEBI:31013 - metanetx.chemical: MNXM46158 - sbo: SBO:0000247 @@ -14724,9 +15944,10 @@ - id: s_2867 - name: hexacosanoyl-CoA - compartment: ce - - formula: C47H86N7O17P3S - - charge: 0 + - formula: C47H82N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: hexccoa - chebi: CHEBI:52966 - metanetx.chemical: MNXM1190 - sbo: SBO:0000247 @@ -14737,6 +15958,7 @@ - formula: C22H43O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: docosac - chebi: CHEBI:23858 - kegg.compound: C08281 - metanetx.chemical: MNXM7102 @@ -14748,6 +15970,7 @@ - formula: C24H47O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: lgnc - chebi: CHEBI:31014 - kegg.compound: C08320 - metanetx.chemical: MNXM3297 @@ -14759,6 +15982,7 @@ - formula: C26H51O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hexc - chebi: CHEBI:31013 - metanetx.chemical: MNXM46158 - sbo: SBO:0000247 @@ -14769,6 +15993,7 @@ - formula: C22H43O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: docosac - chebi: CHEBI:23858 - kegg.compound: C08281 - metanetx.chemical: MNXM7102 @@ -14777,9 +16002,10 @@ - id: s_2872 - name: docosanoyl-CoA - compartment: lp - - formula: C43H78N7O17P3S - - charge: 0 + - formula: C43H74N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: docoscoa - chebi: CHEBI:65088 - kegg.compound: C16528 - metanetx.chemical: MNXM10780 @@ -14791,6 +16017,7 @@ - formula: C24H47O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: lgnc - chebi: CHEBI:31014 - kegg.compound: C08320 - metanetx.chemical: MNXM3297 @@ -14799,9 +16026,10 @@ - id: s_2874 - name: tetracosanoyl-CoA - compartment: lp - - formula: C45H82N7O17P3S - - charge: 0 + - formula: C45H78N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: ttccoa - chebi: CHEBI:52974 - kegg.compound: C16529 - metanetx.chemical: MNXM1504 @@ -14813,6 +16041,7 @@ - formula: C26H51O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hexc - chebi: CHEBI:31013 - metanetx.chemical: MNXM46158 - sbo: SBO:0000247 @@ -14820,9 +16049,10 @@ - id: s_2876 - name: hexacosanoyl-CoA - compartment: lp - - formula: C47H86N7O17P3S - - charge: 0 + - formula: C47H82N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: hexccoa - chebi: CHEBI:52966 - metanetx.chemical: MNXM1190 - sbo: SBO:0000247 @@ -14833,6 +16063,7 @@ - formula: C37H60N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: hdcoa - chebi: CHEBI:61540 - kegg.compound: C21072 - metanetx.chemical: MNXM781 @@ -14841,9 +16072,10 @@ - id: s_2878 - name: icosanoyl-CoA - compartment: c - - formula: C41H74N7O17P3S - - charge: 0 + - formula: C41H70N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: arachcoa - chebi: CHEBI:15527 - kegg.compound: C02041 - metanetx.chemical: MNXM1429 @@ -14852,9 +16084,10 @@ - id: s_2879 - name: icosanoyl-CoA - compartment: p - - formula: C41H74N7O17P3S - - charge: 0 + - formula: C41H70N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: arachcoa - chebi: CHEBI:15527 - kegg.compound: C02041 - metanetx.chemical: MNXM1429 @@ -14863,9 +16096,10 @@ - id: s_2880 - name: docosanoyl-CoA - compartment: c - - formula: C43H78N7O17P3S - - charge: 0 + - formula: C43H74N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: docoscoa - chebi: CHEBI:65088 - kegg.compound: C16528 - metanetx.chemical: MNXM10780 @@ -14874,9 +16108,10 @@ - id: s_2881 - name: docosanoyl-CoA - compartment: p - - formula: C43H78N7O17P3S - - charge: 0 + - formula: C43H74N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: docoscoa - chebi: CHEBI:65088 - kegg.compound: C16528 - metanetx.chemical: MNXM10780 @@ -14888,6 +16123,7 @@ - formula: C4H7O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: but - chebi: CHEBI:17968 - kegg.compound: C00246 - metanetx.chemical: MNXM458 @@ -14899,6 +16135,7 @@ - formula: C6H11O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hxa - chebi: CHEBI:17120 - kegg.compound: C01585 - metanetx.chemical: MNXM1653 @@ -14910,6 +16147,7 @@ - formula: C25H42N7O17P3S - charge: 0 - annotation: !!omap + - bigg.metabolite: btcoa - chebi: CHEBI:15517 - kegg.compound: C00136 - metanetx.chemical: MNXM233 @@ -14921,6 +16159,7 @@ - formula: C27H46N7O17P3S - charge: 0 - annotation: !!omap + - bigg.metabolite: hxcoa - chebi: CHEBI:27540 - kegg.compound: C05270 - metanetx.chemical: MNXM553 @@ -14932,6 +16171,7 @@ - formula: C25H40N7O17P3S - charge: 0 - annotation: !!omap + - bigg.metabolite: b2coa - chebi: CHEBI:36926 - kegg.compound: C00877 - metanetx.chemical: MNXM214 @@ -14943,6 +16183,7 @@ - formula: C27H44N7O17P3S - charge: 0 - annotation: !!omap + - bigg.metabolite: hx2coa - chebi: CHEBI:28706 - kegg.compound: C05271 - metanetx.chemical: MNXM753 @@ -14951,9 +16192,10 @@ - id: s_2888 - name: trans-oct-2-enoyl-CoA - compartment: p - - formula: C29H48N7O17P3S - - charge: 0 + - formula: C29H44N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: oc2coa - chebi: CHEBI:27537 - kegg.compound: C05276 - metanetx.chemical: MNXM784 @@ -14962,26 +16204,30 @@ - id: s_2889 - name: trans-icos-2-enoyl-CoA - compartment: p - - formula: C41H72N7O17P3S - - charge: 0 + - formula: C41H68N7O17P3S + - charge: -4 - annotation: !!omap + - metanetx.chemical: MNXM22115 - sbo: SBO:0000247 - !!omap - id: s_2890 - name: trans-docos-2-enoyl-CoA - compartment: p - - formula: C33H56N7O17P3S - - charge: 0 + - formula: C43H72N7O17P3S + - charge: -4 - annotation: !!omap + - metanetx.chemical: MNXM97615 - sbo: SBO:0000247 - !!omap - id: s_2891 - name: trans-tetracos-2-enoyl-CoA - compartment: p - - formula: C45H80N7O17P3S - - charge: 0 + - formula: C45H76N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2245 - chebi: CHEBI:75068 + - metanetx.chemical: MNXM97616 - sbo: SBO:0000247 - !!omap - id: s_2892 @@ -14990,7 +16236,8 @@ - formula: C37H62N7O17P3S - charge: 0 - annotation: !!omap - - chebi: CHEBI:76889 + - chebi: CHEBI:78178 + - metanetx.chemical: MNXM146680 - sbo: SBO:0000247 - !!omap - id: s_2893 @@ -15021,7 +16268,7 @@ - id: s_2896 - name: trans-2,cis-5-dodecadienoyl-CoA - compartment: p - - formula: C35H54N7O17P3S + - formula: C33H54N7O17P3S - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -15029,9 +16276,10 @@ - id: s_2897 - name: trans-2,cis-9-octadecadienoyl-CoA - compartment: p - - formula: C39H66N7O17P3S - - charge: 0 + - formula: C39H62N7O17P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: lnlccoa - chebi: CHEBI:15530 - kegg.compound: C02050 - metanetx.chemical: MNXM638 @@ -15044,6 +16292,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88008 + - metanetx.chemical: MNXM149511 - sbo: SBO:0000247 - !!omap - id: s_2899 @@ -15062,6 +16311,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:70712 + - metanetx.chemical: MNXM103862 - sbo: SBO:0000247 - !!omap - id: s_2901 @@ -15075,8 +16325,8 @@ - id: s_2902 - name: (R)-3-hydroxybutanoyl-CoA - compartment: p - - formula: C25H42N7O18P3S - - charge: 0 + - formula: C25H38N7O18P3S + - charge: -4 - annotation: !!omap - chebi: CHEBI:15452 - kegg.compound: C03561 @@ -15089,6 +16339,7 @@ - formula: C27H46N7O18P3S - charge: 0 - annotation: !!omap + - bigg.metabolite: R_3hhcoa - chebi: CHEBI:74474 - sbo: SBO:0000247 - !!omap @@ -15098,6 +16349,7 @@ - formula: C29H50N7O18P3S - charge: 0 - annotation: !!omap + - bigg.metabolite: R_3hocoa - chebi: CHEBI:28573 - kegg.compound: C05278 - metanetx.chemical: MNXM31570 @@ -15106,10 +16358,11 @@ - id: s_2905 - name: (R)-3-hydroxyicosanoyl-CoA - compartment: p - - formula: C41H74N7O18P3S - - charge: 0 + - formula: C41H70N7O18P3S + - charge: -4 - annotation: !!omap - chebi: CHEBI:76453 + - metanetx.chemical: MNXM36530 - sbo: SBO:0000247 - !!omap - id: s_2906 @@ -15119,21 +16372,23 @@ - charge: -4 - annotation: !!omap - chebi: CHEBI:76375 + - metanetx.chemical: MNXM162568 - sbo: SBO:0000247 - !!omap - id: s_2907 - name: (R)-3-hydroxytetracosanoyl-CoA - compartment: p - - formula: C45H82N7O18P3S - - charge: 0 + - formula: C45H78N7O18P3S + - charge: -4 - annotation: !!omap - chebi: CHEBI:76463 + - metanetx.chemical: MNXM36558 - sbo: SBO:0000247 - !!omap - id: s_2908 - name: (R)-3-hydroxy-cis-hexadec-9-enoyl-CoA - compartment: p - - formula: C39H68N7O18P3S + - formula: C37H64N7O18P3S - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -15141,6 +16396,7 @@ - id: s_2909 - name: (R)-3-hydroxy-cis-tetradec-7-enoyl-CoA - compartment: p + - formula: C35H60N7O18P3S - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -15148,6 +16404,7 @@ - id: s_2910 - name: (R)-3-hydroxy-cis-dodec-5-enoyl-CoA - compartment: p + - formula: C33H56N7O18P3S - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -15159,6 +16416,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:87781 + - metanetx.chemical: MNXM149457 - sbo: SBO:0000247 - !!omap - id: s_2912 @@ -15185,6 +16443,7 @@ - formula: C25H36N7O18P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: aacoa - chebi: CHEBI:57286 - kegg.compound: C00332 - metanetx.chemical: MNXM133 @@ -15196,6 +16455,7 @@ - formula: C27H44N7O18P3S - charge: 0 - annotation: !!omap + - bigg.metabolite: 3ohcoa - chebi: CHEBI:27648 - kegg.compound: C05269 - metanetx.chemical: MNXM717 @@ -15207,6 +16467,7 @@ - formula: C29H48N7O18P3S - charge: 0 - annotation: !!omap + - bigg.metabolite: 3oocoa - chebi: CHEBI:28264 - kegg.compound: C05267 - metanetx.chemical: MNXM706 @@ -15215,9 +16476,10 @@ - id: s_2917 - name: 3-oxoicosanoyl-CoA - compartment: p - - formula: C41H72N7O18P3S - - charge: 0 + - formula: C41H68N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2251 - chebi: CHEBI:52327 - metanetx.chemical: MNXM36762 - sbo: SBO:0000247 @@ -15225,9 +16487,10 @@ - id: s_2918 - name: 3-oxodocosanoyl-CoA - compartment: p - - formula: C43H76N7O18P3S - - charge: 0 + - formula: C43H72N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2250 - chebi: CHEBI:52328 - metanetx.chemical: MNXM36756 - sbo: SBO:0000247 @@ -15235,9 +16498,10 @@ - id: s_2919 - name: 3-oxotetracosanoyl-CoA - compartment: p - - formula: C45H80N7O18P3S - - charge: 0 + - formula: C45H76N7O18P3S + - charge: -4 - annotation: !!omap + - bigg.metabolite: CE2253 - chebi: CHEBI:52329 - metanetx.chemical: MNXM36773 - sbo: SBO:0000247 @@ -15245,7 +16509,7 @@ - id: s_2920 - name: 3-oxo-cis-hexadec-9-enoyl-CoA - compartment: p - - formula: C37H64N7O17P3S + - formula: C37H62N7O18P3S - charge: 0 - annotation: !!omap - chebi: CHEBI:53152 @@ -15254,7 +16518,7 @@ - id: s_2921 - name: 3-oxo-cis-tetradec-7-enoyl-CoA - compartment: p - - formula: C35H60N7O17P3S + - formula: C35H58N7O18P3S - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -15262,6 +16526,7 @@ - id: s_2922 - name: 3-oxo-cis-dodec-5-enoyl-CoA - compartment: p + - formula: C33H54N7O18P3S - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -15269,7 +16534,7 @@ - id: s_2923 - name: 3-oxo-cis-octadec-9-enoyl-CoA - compartment: p - - formula: C39H68N7O17P3S + - formula: C39H66N7O18P3S - charge: 0 - annotation: !!omap - chebi: CHEBI:78146 @@ -15278,17 +16543,21 @@ - id: s_2924 - name: 3-oxo-cis-hexadec-7-enoyl-CoA - compartment: p - - formula: C37H64N7O17P3S + - formula: C37H62N7O18P3S - charge: 0 - annotation: !!omap + - chebi: CHEBI:88090 + - metanetx.chemical: MNXM150996 - sbo: SBO:0000247 - !!omap - id: s_2925 - name: 3-oxo-cis-tetradec-5-enoyl-CoA - compartment: p - - formula: C35H60N7O17P3S + - formula: C35H58N7O18P3S - charge: 0 - annotation: !!omap + - chebi: CHEBI:88080 + - metanetx.chemical: MNXM147795 - sbo: SBO:0000247 - !!omap - id: s_2926 @@ -15297,6 +16566,7 @@ - formula: C31H52N7O17P3S - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM164218 - sbo: SBO:0000247 - !!omap - id: s_2927 @@ -15306,6 +16576,8 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:27989 + - kegg.compound: C02944 + - metanetx.chemical: MNXM3949 - sbo: SBO:0000247 - !!omap - id: s_2928 @@ -15323,6 +16595,7 @@ - formula: C33H56N7O17P3S - charge: 0 - annotation: !!omap + - bigg.metabolite: dd3coa - sbo: SBO:0000247 - !!omap - id: s_2930 @@ -15332,6 +16605,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:72001 + - metanetx.chemical: MNXM9966 - sbo: SBO:0000247 - !!omap - id: s_2931 @@ -15341,6 +16615,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88083 + - metanetx.chemical: MNXM7189 - sbo: SBO:0000247 - !!omap - id: s_2932 @@ -15357,10 +16632,11 @@ - id: s_2933 - name: trans-2,trans-4-tetradecadienoyl-CoA - compartment: p - - formula: C35H54N7O17P3S + - formula: C35H58N7O17P3S - charge: 0 - annotation: !!omap - chebi: CHEBI:88084 + - metanetx.chemical: MNXM147629 - sbo: SBO:0000247 - !!omap - id: s_2934 @@ -15369,6 +16645,7 @@ - formula: C3H7O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: glyc3p - chebi: CHEBI:57597 - kegg.compound: C00093 - metanetx.chemical: MNXM66 @@ -15380,6 +16657,7 @@ - formula: C19H39O7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1hdecg3p - chebi: CHEBI:15799 - kegg.compound: C04036 - metanetx.chemical: MNXM2455 @@ -15392,6 +16670,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75070 + - metanetx.chemical: MNXM66496 - sbo: SBO:0000247 - !!omap - id: s_2937 @@ -15400,7 +16679,9 @@ - formula: C21H43O7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1odecg3p - chebi: CHEBI:74850 + - metanetx.chemical: MNXM32950 - sbo: SBO:0000247 - !!omap - id: s_2938 @@ -15410,6 +16691,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:62837 + - metanetx.chemical: MNXM32960 - sbo: SBO:0000247 - !!omap - id: s_2939 @@ -15418,6 +16700,7 @@ - formula: C3H5O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: dhap - chebi: CHEBI:57642 - kegg.compound: C00111 - metanetx.chemical: MNXM77 @@ -15438,16 +16721,15 @@ - name: acylglycerone phosphate (16:1) - compartment: erm - formula: C19H35O7P - - charge: -2 + - charge: 0 - annotation: !!omap - - chebi: CHEBI:74694 - sbo: SBO:0000247 - !!omap - id: s_2942 - name: acylglycerone phosphate (18:0) - compartment: erm - - formula: C21H39O7P - - charge: -2 + - formula: C21H41O7P + - charge: 0 - annotation: !!omap - chebi: CHEBI:36476 - kegg.compound: C03805 @@ -15457,7 +16739,7 @@ - id: s_2943 - name: acylglycerone phosphate (18:1) - compartment: erm - - formula: C35H65O8P + - formula: C21H39O7P - charge: 0 - annotation: !!omap - chebi: CHEBI:36475 @@ -15471,6 +16753,7 @@ - formula: C19H39O7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1hdecg3p - chebi: CHEBI:15799 - kegg.compound: C04036 - metanetx.chemical: MNXM2455 @@ -15483,6 +16766,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75070 + - metanetx.chemical: MNXM66496 - sbo: SBO:0000247 - !!omap - id: s_2946 @@ -15491,7 +16775,9 @@ - formula: C21H43O7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1odecg3p - chebi: CHEBI:74850 + - metanetx.chemical: MNXM32950 - sbo: SBO:0000247 - !!omap - id: s_2947 @@ -15501,6 +16787,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:62837 + - metanetx.chemical: MNXM32960 - sbo: SBO:0000247 - !!omap - id: s_2948 @@ -15518,16 +16805,15 @@ - name: acylglycerone phosphate (16:1) - compartment: lp - formula: C19H35O7P - - charge: -2 + - charge: 0 - annotation: !!omap - - chebi: CHEBI:74694 - sbo: SBO:0000247 - !!omap - id: s_2950 - name: acylglycerone phosphate (18:0) - compartment: lp - - formula: C21H39O7P - - charge: -2 + - formula: C21H41O7P + - charge: 0 - annotation: !!omap - chebi: CHEBI:36476 - kegg.compound: C03805 @@ -15537,7 +16823,7 @@ - id: s_2951 - name: acylglycerone phosphate (18:1) - compartment: lp - - formula: C35H65O8P + - formula: C21H39O7P - charge: 0 - annotation: !!omap - chebi: CHEBI:36475 @@ -15551,6 +16837,7 @@ - formula: C21H26N7O17P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: nadph - chebi: CHEBI:57783 - kegg.compound: C00005 - metanetx.chemical: MNXM6 @@ -15562,6 +16849,7 @@ - formula: C21H25N7O17P3 - charge: -3 - annotation: !!omap + - bigg.metabolite: nadp - chebi: CHEBI:58349 - kegg.compound: C00006 - metanetx.chemical: MNXM5 @@ -15570,10 +16858,11 @@ - id: s_2954 - name: phosphatidate (1-16:0, 2-16:1) - compartment: erm - - formula: C35H65O8P - - charge: -2 + - formula: C35H67O8P + - charge: 0 - annotation: !!omap - chebi: CHEBI:73998 + - metanetx.chemical: MNXM66470 - sbo: SBO:0000247 - !!omap - id: s_2955 @@ -15593,7 +16882,9 @@ - formula: C35H65O8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pa161 - chebi: CHEBI:75071 + - metanetx.chemical: MNXM66504 - sbo: SBO:0000247 - !!omap - id: s_2957 @@ -15602,6 +16893,7 @@ - formula: C37H69O8P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM66509 - sbo: SBO:0000247 - !!omap - id: s_2958 @@ -15611,6 +16903,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75073 + - metanetx.chemical: MNXM66631 - sbo: SBO:0000247 - !!omap - id: s_2959 @@ -15620,6 +16913,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:74847 + - metanetx.chemical: MNXM66635 - sbo: SBO:0000247 - !!omap - id: s_2960 @@ -15629,6 +16923,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75074 + - metanetx.chemical: MNXM66663 - sbo: SBO:0000247 - !!omap - id: s_2961 @@ -15638,6 +16933,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:83775 + - metanetx.chemical: MNXM51075 - sbo: SBO:0000247 - !!omap - id: s_2962 @@ -15657,6 +16953,7 @@ - formula: C37H69O8P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM66509 - sbo: SBO:0000247 - !!omap - id: s_2964 @@ -15666,6 +16963,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:74847 + - metanetx.chemical: MNXM66635 - sbo: SBO:0000247 - !!omap - id: s_2965 @@ -15675,6 +16973,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:83775 + - metanetx.chemical: MNXM51075 - sbo: SBO:0000247 - !!omap - id: s_2966 @@ -15683,6 +16982,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -15691,10 +16991,11 @@ - id: s_2967 - name: diglyceride (1-16:0, 2-16:1) - compartment: erm - - formula: C35H68O5 + - formula: C35H66O5 - charge: 0 - annotation: !!omap - - chebi: CHEBI:82929 + - chebi: CHEBI:84394 + - metanetx.chemical: MNXM49375 - sbo: SBO:0000247 - !!omap - id: s_2968 @@ -15704,6 +17005,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88454 + - metanetx.chemical: MNXM49380 - sbo: SBO:0000247 - !!omap - id: s_2969 @@ -15712,7 +17014,9 @@ - formula: C35H64O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr161 - chebi: CHEBI:84417 + - metanetx.chemical: MNXM176611 - sbo: SBO:0000247 - !!omap - id: s_2970 @@ -15722,6 +17026,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88500 + - metanetx.chemical: MNXM49417 - sbo: SBO:0000247 - !!omap - id: s_2971 @@ -15731,6 +17036,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88527 + - metanetx.chemical: MNXM49511 - sbo: SBO:0000247 - !!omap - id: s_2972 @@ -15740,6 +17046,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75468 + - metanetx.chemical: MNXM49514 - sbo: SBO:0000247 - !!omap - id: s_2973 @@ -15749,6 +17056,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89229 + - metanetx.chemical: MNXM49575 - sbo: SBO:0000247 - !!omap - id: s_2974 @@ -15757,16 +17065,19 @@ - formula: C39H72O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr181 - chebi: CHEBI:52333 + - metanetx.chemical: MNXM9533 - sbo: SBO:0000247 - !!omap - id: s_2975 - name: phosphatidate (1-16:0, 2-16:1) - compartment: vm - - formula: C35H65O8P - - charge: -2 + - formula: C35H67O8P + - charge: 0 - annotation: !!omap - chebi: CHEBI:73998 + - metanetx.chemical: MNXM66470 - sbo: SBO:0000247 - !!omap - id: s_2976 @@ -15775,6 +17086,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -15786,6 +17098,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -15794,10 +17107,11 @@ - id: s_2978 - name: diglyceride (1-16:0, 2-16:1) - compartment: vm - - formula: C35H68O5 + - formula: C35H66O5 - charge: 0 - annotation: !!omap - - chebi: CHEBI:82929 + - chebi: CHEBI:84394 + - metanetx.chemical: MNXM49375 - sbo: SBO:0000247 - !!omap - id: s_2979 @@ -15818,6 +17132,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88454 + - metanetx.chemical: MNXM49380 - sbo: SBO:0000247 - !!omap - id: s_2981 @@ -15826,7 +17141,9 @@ - formula: C35H65O8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pa161 - chebi: CHEBI:75071 + - metanetx.chemical: MNXM66504 - sbo: SBO:0000247 - !!omap - id: s_2982 @@ -15835,7 +17152,9 @@ - formula: C35H64O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr161 - chebi: CHEBI:84417 + - metanetx.chemical: MNXM176611 - sbo: SBO:0000247 - !!omap - id: s_2983 @@ -15844,6 +17163,7 @@ - formula: C37H69O8P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM66509 - sbo: SBO:0000247 - !!omap - id: s_2984 @@ -15853,6 +17173,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88500 + - metanetx.chemical: MNXM49417 - sbo: SBO:0000247 - !!omap - id: s_2985 @@ -15862,6 +17183,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75073 + - metanetx.chemical: MNXM66631 - sbo: SBO:0000247 - !!omap - id: s_2986 @@ -15871,6 +17193,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88527 + - metanetx.chemical: MNXM49511 - sbo: SBO:0000247 - !!omap - id: s_2987 @@ -15880,6 +17203,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:74847 + - metanetx.chemical: MNXM66635 - sbo: SBO:0000247 - !!omap - id: s_2988 @@ -15889,6 +17213,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75468 + - metanetx.chemical: MNXM49514 - sbo: SBO:0000247 - !!omap - id: s_2989 @@ -15898,6 +17223,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75074 + - metanetx.chemical: MNXM66663 - sbo: SBO:0000247 - !!omap - id: s_2990 @@ -15907,6 +17233,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89229 + - metanetx.chemical: MNXM49575 - sbo: SBO:0000247 - !!omap - id: s_2991 @@ -15916,6 +17243,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:83775 + - metanetx.chemical: MNXM51075 - sbo: SBO:0000247 - !!omap - id: s_2992 @@ -15924,16 +17252,19 @@ - formula: C39H72O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr181 - chebi: CHEBI:52333 + - metanetx.chemical: MNXM9533 - sbo: SBO:0000247 - !!omap - id: s_2993 - name: phosphatidate (1-16:0, 2-16:1) - compartment: gm - - formula: C35H65O8P - - charge: -2 + - formula: C35H67O8P + - charge: 0 - annotation: !!omap - chebi: CHEBI:73998 + - metanetx.chemical: MNXM66470 - sbo: SBO:0000247 - !!omap - id: s_2994 @@ -15942,6 +17273,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -15953,6 +17285,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -15961,10 +17294,11 @@ - id: s_2996 - name: diglyceride (1-16:0, 2-16:1) - compartment: gm - - formula: C35H68O5 + - formula: C35H66O5 - charge: 0 - annotation: !!omap - - chebi: CHEBI:82929 + - chebi: CHEBI:84394 + - metanetx.chemical: MNXM49375 - sbo: SBO:0000247 - !!omap - id: s_2997 @@ -15985,6 +17319,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88454 + - metanetx.chemical: MNXM49380 - sbo: SBO:0000247 - !!omap - id: s_2999 @@ -15993,7 +17328,9 @@ - formula: C35H65O8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pa161 - chebi: CHEBI:75071 + - metanetx.chemical: MNXM66504 - sbo: SBO:0000247 - !!omap - id: s_3000 @@ -16002,7 +17339,9 @@ - formula: C35H64O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr161 - chebi: CHEBI:84417 + - metanetx.chemical: MNXM176611 - sbo: SBO:0000247 - !!omap - id: s_3001 @@ -16011,6 +17350,7 @@ - formula: C37H69O8P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM66509 - sbo: SBO:0000247 - !!omap - id: s_3002 @@ -16020,6 +17360,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88500 + - metanetx.chemical: MNXM49417 - sbo: SBO:0000247 - !!omap - id: s_3003 @@ -16029,6 +17370,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75073 + - metanetx.chemical: MNXM66631 - sbo: SBO:0000247 - !!omap - id: s_3004 @@ -16038,6 +17380,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88527 + - metanetx.chemical: MNXM49511 - sbo: SBO:0000247 - !!omap - id: s_3005 @@ -16047,6 +17390,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:74847 + - metanetx.chemical: MNXM66635 - sbo: SBO:0000247 - !!omap - id: s_3006 @@ -16056,6 +17400,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75468 + - metanetx.chemical: MNXM49514 - sbo: SBO:0000247 - !!omap - id: s_3007 @@ -16065,6 +17410,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75074 + - metanetx.chemical: MNXM66663 - sbo: SBO:0000247 - !!omap - id: s_3008 @@ -16074,6 +17420,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89229 + - metanetx.chemical: MNXM49575 - sbo: SBO:0000247 - !!omap - id: s_3009 @@ -16083,6 +17430,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:83775 + - metanetx.chemical: MNXM51075 - sbo: SBO:0000247 - !!omap - id: s_3010 @@ -16091,7 +17439,9 @@ - formula: C39H72O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr181 - chebi: CHEBI:52333 + - metanetx.chemical: MNXM9533 - sbo: SBO:0000247 - !!omap - id: s_3011 @@ -16101,6 +17451,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:85427 + - metanetx.chemical: MNXM84113 - sbo: SBO:0000247 - !!omap - id: s_3012 @@ -16110,6 +17461,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89759 + - metanetx.chemical: MNXM84120 - sbo: SBO:0000247 - !!omap - id: s_3013 @@ -16118,6 +17470,7 @@ - formula: C51H94O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag1619Z1619Z160 - sbo: SBO:0000247 - !!omap - id: s_3014 @@ -16143,6 +17496,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89755 + - metanetx.chemical: MNXM84227 - sbo: SBO:0000247 - !!omap - id: s_3017 @@ -16160,6 +17514,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88999 + - metanetx.chemical: MNXM85598 - sbo: SBO:0000247 - !!omap - id: s_3019 @@ -16169,6 +17524,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89765 + - metanetx.chemical: MNXM84138 - sbo: SBO:0000247 - !!omap - id: s_3020 @@ -16185,7 +17541,9 @@ - formula: C51H92O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag1619Z1619Z1619Z - chebi: CHEBI:75841 + - metanetx.chemical: MNXM84424 - sbo: SBO:0000247 - !!omap - id: s_3022 @@ -16203,6 +17561,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90053 + - metanetx.chemical: MNXM84428 - sbo: SBO:0000247 - !!omap - id: s_3024 @@ -16219,6 +17578,7 @@ - formula: C53H96O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag1819Z1619Z1619Z - sbo: SBO:0000247 - !!omap - id: s_3026 @@ -16236,6 +17596,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89763 + - metanetx.chemical: MNXM84142 - sbo: SBO:0000247 - !!omap - id: s_3028 @@ -16245,6 +17606,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88998 + - metanetx.chemical: MNXM85401 - sbo: SBO:0000247 - !!omap - id: s_3029 @@ -16270,6 +17632,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89958 + - metanetx.chemical: MNXM84510 - sbo: SBO:0000247 - !!omap - id: s_3032 @@ -16319,7 +17682,9 @@ - formula: C53H96O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag1619Z1619Z1819Z - chebi: CHEBI:90051 + - metanetx.chemical: MNXM84429 - sbo: SBO:0000247 - !!omap - id: s_3038 @@ -16329,6 +17694,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90048 + - metanetx.chemical: MNXM84530 - sbo: SBO:0000247 - !!omap - id: s_3039 @@ -16353,7 +17719,9 @@ - formula: C55H100O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag1819Z1619Z1819Z - chebi: CHEBI:88984 + - metanetx.chemical: MNXM85603 - sbo: SBO:0000247 - !!omap - id: s_3042 @@ -16363,15 +17731,17 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88970 + - metanetx.chemical: MNXM85618 - sbo: SBO:0000247 - !!omap - id: s_3043 - name: diglyceride (1-16:0, 2-16:1) - compartment: lp - - formula: C35H68O5 + - formula: C35H66O5 - charge: 0 - annotation: !!omap - - chebi: CHEBI:82929 + - chebi: CHEBI:84394 + - metanetx.chemical: MNXM49375 - sbo: SBO:0000247 - !!omap - id: s_3044 @@ -16381,6 +17751,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:85427 + - metanetx.chemical: MNXM84113 - sbo: SBO:0000247 - !!omap - id: s_3045 @@ -16390,6 +17761,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88454 + - metanetx.chemical: MNXM49380 - sbo: SBO:0000247 - !!omap - id: s_3046 @@ -16399,6 +17771,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89759 + - metanetx.chemical: MNXM84120 - sbo: SBO:0000247 - !!omap - id: s_3047 @@ -16407,7 +17780,9 @@ - formula: C35H64O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr161 - chebi: CHEBI:84417 + - metanetx.chemical: MNXM176611 - sbo: SBO:0000247 - !!omap - id: s_3048 @@ -16416,6 +17791,7 @@ - formula: C51H94O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag1619Z1619Z160 - sbo: SBO:0000247 - !!omap - id: s_3049 @@ -16425,6 +17801,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88500 + - metanetx.chemical: MNXM49417 - sbo: SBO:0000247 - !!omap - id: s_3050 @@ -16442,6 +17819,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88527 + - metanetx.chemical: MNXM49511 - sbo: SBO:0000247 - !!omap - id: s_3052 @@ -16459,6 +17837,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75468 + - metanetx.chemical: MNXM49514 - sbo: SBO:0000247 - !!omap - id: s_3054 @@ -16468,6 +17847,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89755 + - metanetx.chemical: MNXM84227 - sbo: SBO:0000247 - !!omap - id: s_3055 @@ -16477,6 +17857,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89229 + - metanetx.chemical: MNXM49575 - sbo: SBO:0000247 - !!omap - id: s_3056 @@ -16493,7 +17874,9 @@ - formula: C39H72O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr181 - chebi: CHEBI:52333 + - metanetx.chemical: MNXM9533 - sbo: SBO:0000247 - !!omap - id: s_3058 @@ -16503,6 +17886,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88999 + - metanetx.chemical: MNXM85598 - sbo: SBO:0000247 - !!omap - id: s_3059 @@ -16512,6 +17896,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89765 + - metanetx.chemical: MNXM84138 - sbo: SBO:0000247 - !!omap - id: s_3060 @@ -16528,7 +17913,9 @@ - formula: C51H92O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag1619Z1619Z1619Z - chebi: CHEBI:75841 + - metanetx.chemical: MNXM84424 - sbo: SBO:0000247 - !!omap - id: s_3062 @@ -16546,6 +17933,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90053 + - metanetx.chemical: MNXM84428 - sbo: SBO:0000247 - !!omap - id: s_3064 @@ -16562,6 +17950,7 @@ - formula: C53H96O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag1819Z1619Z1619Z - sbo: SBO:0000247 - !!omap - id: s_3066 @@ -16579,6 +17968,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89763 + - metanetx.chemical: MNXM84142 - sbo: SBO:0000247 - !!omap - id: s_3068 @@ -16588,6 +17978,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88998 + - metanetx.chemical: MNXM85401 - sbo: SBO:0000247 - !!omap - id: s_3069 @@ -16613,6 +18004,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89958 + - metanetx.chemical: MNXM84510 - sbo: SBO:0000247 - !!omap - id: s_3072 @@ -16662,7 +18054,9 @@ - formula: C53H96O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag1619Z1619Z1819Z - chebi: CHEBI:90051 + - metanetx.chemical: MNXM84429 - sbo: SBO:0000247 - !!omap - id: s_3078 @@ -16672,6 +18066,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90048 + - metanetx.chemical: MNXM84530 - sbo: SBO:0000247 - !!omap - id: s_3079 @@ -16696,7 +18091,9 @@ - formula: C55H100O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag1819Z1619Z1819Z - chebi: CHEBI:88984 + - metanetx.chemical: MNXM85603 - sbo: SBO:0000247 - !!omap - id: s_3082 @@ -16706,6 +18103,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88970 + - metanetx.chemical: MNXM85618 - sbo: SBO:0000247 - !!omap - id: s_3083 @@ -16714,6 +18112,7 @@ - formula: C9H12N3O14P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: ctp - chebi: CHEBI:37563 - kegg.compound: C00063 - metanetx.chemical: MNXM63 @@ -16734,6 +18133,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:104012 + - metanetx.chemical: MNXM4508 - sbo: SBO:0000247 - !!omap - id: s_3086 @@ -16774,7 +18174,7 @@ - id: s_3090 - name: CDP-diacylglycerol (1-18:0, 2-18:1) - compartment: erm - - formula: C48H83N3O15P2 + - formula: C48H87N3O15P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -16791,10 +18191,11 @@ - id: s_3092 - name: phosphatidate (1-16:0, 2-16:1) - compartment: mm - - formula: C35H65O8P - - charge: -2 + - formula: C35H67O8P + - charge: 0 - annotation: !!omap - chebi: CHEBI:73998 + - metanetx.chemical: MNXM66470 - sbo: SBO:0000247 - !!omap - id: s_3093 @@ -16803,6 +18204,7 @@ - formula: C9H12N3O14P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: ctp - chebi: CHEBI:37563 - kegg.compound: C00063 - metanetx.chemical: MNXM63 @@ -16814,6 +18216,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -16825,6 +18228,7 @@ - formula: HO7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ppi - chebi: CHEBI:33019 - kegg.compound: C00013 - metanetx.chemical: MNXM11 @@ -16844,7 +18248,9 @@ - formula: C35H65O8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pa161 - chebi: CHEBI:75071 + - metanetx.chemical: MNXM66504 - sbo: SBO:0000247 - !!omap - id: s_3098 @@ -16854,6 +18260,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:104012 + - metanetx.chemical: MNXM4508 - sbo: SBO:0000247 - !!omap - id: s_3099 @@ -16863,6 +18270,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75073 + - metanetx.chemical: MNXM66631 - sbo: SBO:0000247 - !!omap - id: s_3100 @@ -16880,6 +18288,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75074 + - metanetx.chemical: MNXM66663 - sbo: SBO:0000247 - !!omap - id: s_3102 @@ -16918,6 +18327,7 @@ - formula: C37H69O8P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM66509 - sbo: SBO:0000247 - !!omap - id: s_3106 @@ -16934,6 +18344,7 @@ - formula: C3H7NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ser__L - chebi: CHEBI:17115 - kegg.compound: C00065 - metanetx.chemical: MNXM53 @@ -16945,6 +18356,7 @@ - formula: C9H12N3O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: cmp - chebi: CHEBI:60377 - kegg.compound: C00055 - metanetx.chemical: MNXM31 @@ -16957,6 +18369,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89824 + - metanetx.chemical: MNXM78605 - sbo: SBO:0000247 - !!omap - id: s_3110 @@ -16965,6 +18378,7 @@ - formula: C38H70NO10P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM78637 - sbo: SBO:0000247 - !!omap - id: s_3111 @@ -16974,6 +18388,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90036 + - metanetx.chemical: MNXM78765 - sbo: SBO:0000247 - !!omap - id: s_3112 @@ -16983,6 +18398,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75101 + - metanetx.chemical: MNXM78797 - sbo: SBO:0000247 - !!omap - id: s_3113 @@ -16991,7 +18407,9 @@ - formula: C40H76NO10P - charge: 0 - annotation: !!omap - - chebi: CHEBI:134541 + - chebi: CHEBI:34086 + - kegg.compound: C13880 + - metanetx.chemical: MNXM32501 - sbo: SBO:0000247 - !!omap - id: s_3114 @@ -17001,6 +18419,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90032 + - metanetx.chemical: MNXM78642 - sbo: SBO:0000247 - !!omap - id: s_3115 @@ -17009,7 +18428,8 @@ - formula: C42H80NO10P - charge: 0 - annotation: !!omap - - chebi: CHEBI:90433 + - chebi: CHEBI:79096 + - metanetx.chemical: MNXM32529 - sbo: SBO:0000247 - !!omap - id: s_3116 @@ -17019,6 +18439,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:60568 + - metanetx.chemical: MNXM32173 - sbo: SBO:0000247 - !!omap - id: s_3117 @@ -17027,6 +18448,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: inost - chebi: CHEBI:17268 - kegg.compound: C00137 - metanetx.chemical: MNXM127 @@ -17039,6 +18461,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88396 + - metanetx.chemical: MNXM75492 - sbo: SBO:0000247 - !!omap - id: s_3119 @@ -17047,6 +18470,7 @@ - formula: C41H75O13P - charge: 0 - annotation: !!omap + - bigg.metabolite: pail161 - sbo: SBO:0000247 - !!omap - id: s_3120 @@ -17056,6 +18480,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88557 + - metanetx.chemical: MNXM75665 - sbo: SBO:0000247 - !!omap - id: s_3121 @@ -17075,6 +18500,7 @@ - annotation: !!omap - chebi: CHEBI:73215 - kegg.compound: C13888 + - metanetx.chemical: MNXM75499 - sbo: SBO:0000247 - !!omap - id: s_3123 @@ -17093,6 +18519,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:77346 + - metanetx.chemical: MNXM75671 - sbo: SBO:0000247 - !!omap - id: s_3125 @@ -17107,15 +18534,16 @@ - id: s_3126 - name: sn-2-acyl-1-lysophosphatidylinositol (16:1) - compartment: erm - - formula: C25H41O12P + - formula: C25H47O12P - charge: 0 - annotation: !!omap + - chebi: CHEBI:138108 - sbo: SBO:0000247 - !!omap - id: s_3127 - name: sn-2-acyl-1-lysophosphatidylinositol (18:1) - compartment: erm - - formula: C27H45O12P + - formula: C27H51O12P - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -17127,6 +18555,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89824 + - metanetx.chemical: MNXM78605 - sbo: SBO:0000247 - !!omap - id: s_3129 @@ -17135,6 +18564,7 @@ - formula: CO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: co2 - chebi: CHEBI:16526 - kegg.compound: C00011 - metanetx.chemical: MNXM13 @@ -17155,6 +18585,7 @@ - formula: C38H70NO10P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM78637 - sbo: SBO:0000247 - !!omap - id: s_3132 @@ -17163,6 +18594,7 @@ - formula: C37H70NO8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pe161 - chebi: CHEBI:138792 - sbo: SBO:0000247 - !!omap @@ -17173,6 +18605,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90036 + - metanetx.chemical: MNXM78765 - sbo: SBO:0000247 - !!omap - id: s_3134 @@ -17191,6 +18624,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75101 + - metanetx.chemical: MNXM78797 - sbo: SBO:0000247 - !!omap - id: s_3136 @@ -17200,6 +18634,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:82837 + - metanetx.chemical: MNXM71684 - sbo: SBO:0000247 - !!omap - id: s_3137 @@ -17208,7 +18643,9 @@ - formula: C40H76NO10P - charge: 0 - annotation: !!omap - - chebi: CHEBI:134541 + - chebi: CHEBI:34086 + - kegg.compound: C13880 + - metanetx.chemical: MNXM32501 - sbo: SBO:0000247 - !!omap - id: s_3138 @@ -17227,6 +18664,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90032 + - metanetx.chemical: MNXM78642 - sbo: SBO:0000247 - !!omap - id: s_3140 @@ -17244,7 +18682,8 @@ - formula: C42H80NO10P - charge: 0 - annotation: !!omap - - chebi: CHEBI:90433 + - chebi: CHEBI:79096 + - metanetx.chemical: MNXM32529 - sbo: SBO:0000247 - !!omap - id: s_3142 @@ -17263,6 +18702,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:60568 + - metanetx.chemical: MNXM32173 - sbo: SBO:0000247 - !!omap - id: s_3144 @@ -17281,6 +18721,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89824 + - metanetx.chemical: MNXM78605 - sbo: SBO:0000247 - !!omap - id: s_3146 @@ -17289,6 +18730,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -17300,6 +18742,7 @@ - formula: CO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: co2 - chebi: CHEBI:16526 - kegg.compound: C00011 - metanetx.chemical: MNXM13 @@ -17320,6 +18763,7 @@ - formula: C38H70NO10P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM78637 - sbo: SBO:0000247 - !!omap - id: s_3150 @@ -17328,6 +18772,7 @@ - formula: C37H70NO8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pe161 - chebi: CHEBI:138792 - sbo: SBO:0000247 - !!omap @@ -17338,6 +18783,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90036 + - metanetx.chemical: MNXM78765 - sbo: SBO:0000247 - !!omap - id: s_3152 @@ -17356,6 +18802,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75101 + - metanetx.chemical: MNXM78797 - sbo: SBO:0000247 - !!omap - id: s_3154 @@ -17365,6 +18812,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:82837 + - metanetx.chemical: MNXM71684 - sbo: SBO:0000247 - !!omap - id: s_3155 @@ -17373,7 +18821,9 @@ - formula: C40H76NO10P - charge: 0 - annotation: !!omap - - chebi: CHEBI:134541 + - chebi: CHEBI:34086 + - kegg.compound: C13880 + - metanetx.chemical: MNXM32501 - sbo: SBO:0000247 - !!omap - id: s_3156 @@ -17392,6 +18842,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90032 + - metanetx.chemical: MNXM78642 - sbo: SBO:0000247 - !!omap - id: s_3158 @@ -17409,7 +18860,8 @@ - formula: C42H80NO10P - charge: 0 - annotation: !!omap - - chebi: CHEBI:90433 + - chebi: CHEBI:79096 + - metanetx.chemical: MNXM32529 - sbo: SBO:0000247 - !!omap - id: s_3160 @@ -17428,6 +18880,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:60568 + - metanetx.chemical: MNXM32173 - sbo: SBO:0000247 - !!omap - id: s_3162 @@ -17446,6 +18899,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89824 + - metanetx.chemical: MNXM78605 - sbo: SBO:0000247 - !!omap - id: s_3164 @@ -17454,6 +18908,7 @@ - formula: H - charge: 1 - annotation: !!omap + - bigg.metabolite: h - chebi: CHEBI:24636 - kegg.compound: C00080 - metanetx.chemical: MNXM1 @@ -17465,6 +18920,7 @@ - formula: CO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: co2 - chebi: CHEBI:16526 - kegg.compound: C00011 - metanetx.chemical: MNXM13 @@ -17485,6 +18941,7 @@ - formula: C38H70NO10P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM78637 - sbo: SBO:0000247 - !!omap - id: s_3168 @@ -17493,6 +18950,7 @@ - formula: C37H70NO8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pe161 - chebi: CHEBI:138792 - sbo: SBO:0000247 - !!omap @@ -17503,6 +18961,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90036 + - metanetx.chemical: MNXM78765 - sbo: SBO:0000247 - !!omap - id: s_3170 @@ -17521,6 +18980,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75101 + - metanetx.chemical: MNXM78797 - sbo: SBO:0000247 - !!omap - id: s_3172 @@ -17530,6 +18990,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:82837 + - metanetx.chemical: MNXM71684 - sbo: SBO:0000247 - !!omap - id: s_3173 @@ -17538,7 +18999,9 @@ - formula: C40H76NO10P - charge: 0 - annotation: !!omap - - chebi: CHEBI:134541 + - chebi: CHEBI:34086 + - kegg.compound: C13880 + - metanetx.chemical: MNXM32501 - sbo: SBO:0000247 - !!omap - id: s_3174 @@ -17557,6 +19020,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90032 + - metanetx.chemical: MNXM78642 - sbo: SBO:0000247 - !!omap - id: s_3176 @@ -17574,7 +19038,8 @@ - formula: C42H80NO10P - charge: 0 - annotation: !!omap - - chebi: CHEBI:90433 + - chebi: CHEBI:79096 + - metanetx.chemical: MNXM32529 - sbo: SBO:0000247 - !!omap - id: s_3178 @@ -17593,6 +19058,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:60568 + - metanetx.chemical: MNXM32173 - sbo: SBO:0000247 - !!omap - id: s_3180 @@ -17619,6 +19085,7 @@ - formula: C15H23N6O5S - charge: 1 - annotation: !!omap + - bigg.metabolite: amet - chebi: CHEBI:15414 - kegg.compound: C00019 - metanetx.chemical: MNXM16 @@ -17630,6 +19097,7 @@ - formula: C14H20N6O5S - charge: 0 - annotation: !!omap + - bigg.metabolite: ahcys - chebi: CHEBI:16680 - kegg.compound: C00021 - metanetx.chemical: MNXM19 @@ -17649,6 +19117,7 @@ - formula: C37H70NO8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pe161 - chebi: CHEBI:138792 - sbo: SBO:0000247 - !!omap @@ -17684,6 +19153,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:82837 + - metanetx.chemical: MNXM71684 - sbo: SBO:0000247 - !!omap - id: s_3190 @@ -17761,6 +19231,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:85962 + - metanetx.chemical: MNXM72986 - sbo: SBO:0000247 - !!omap - id: s_3199 @@ -17826,6 +19297,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:85963 + - metanetx.chemical: MNXM72998 - sbo: SBO:0000247 - !!omap - id: s_3207 @@ -17843,25 +19315,29 @@ - formula: C40H76NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:134637 + - bigg.metabolite: pc161 + - chebi: CHEBI:83717 + - metanetx.chemical: MNXM69377 - sbo: SBO:0000247 - !!omap - id: s_3209 - name: phosphatidylcholine (1-18:0, 2-16:1) - compartment: erm - - formula: C42H82NO7P + - formula: C42H82NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89972 + - chebi: CHEBI:86097 + - metanetx.chemical: MNXM69528 - sbo: SBO:0000247 - !!omap - id: s_3210 - name: phosphatidylcholine (1-18:1, 2-16:1) - compartment: erm - - formula: C42H80NO7P + - formula: C42H80NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89506 + - chebi: CHEBI:86100 + - metanetx.chemical: MNXM69658 - sbo: SBO:0000247 - !!omap - id: s_3211 @@ -17879,25 +19355,28 @@ - formula: C42H80NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89668 + - chebi: CHEBI:84811 + - metanetx.chemical: MNXM69383 - sbo: SBO:0000247 - !!omap - id: s_3213 - name: phosphatidylcholine (1-18:0, 2-18:1) - compartment: erm - - formula: C44H86NO7P + - formula: C44H86NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89679 + - chebi: CHEBI:75034 + - metanetx.chemical: MNXM32526 - sbo: SBO:0000247 - !!omap - id: s_3214 - name: phosphatidylcholine (1-18:1, 2-18:1) - compartment: erm - - formula: C44H84NO7P + - formula: C44H84NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89504 + - chebi: CHEBI:74669 + - metanetx.chemical: MNXM8549 - sbo: SBO:0000247 - !!omap - id: s_3215 @@ -17906,6 +19385,7 @@ - formula: C9H12N3O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: cdp - chebi: CHEBI:58069 - kegg.compound: C00112 - metanetx.chemical: MNXM220 @@ -17917,6 +19397,7 @@ - formula: C11H19N4O11P2 - charge: -1 - annotation: !!omap + - bigg.metabolite: cdpea - chebi: CHEBI:57876 - kegg.compound: C00570 - metanetx.chemical: MNXM449 @@ -17925,9 +19406,10 @@ - id: s_3217 - name: CDP-choline - compartment: erm - - formula: C14H26N4O11P2 - - charge: 0 + - formula: C14H25N4O11P2 + - charge: -1 - annotation: !!omap + - bigg.metabolite: cdpchol - chebi: CHEBI:16436 - kegg.compound: C00307 - metanetx.chemical: MNXM283 @@ -17939,6 +19421,7 @@ - formula: C3H7O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: glyc3p - chebi: CHEBI:57597 - kegg.compound: C00093 - metanetx.chemical: MNXM66 @@ -17950,6 +19433,7 @@ - formula: C9H12N3O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: cmp - chebi: CHEBI:60377 - kegg.compound: C00055 - metanetx.chemical: MNXM31 @@ -17958,7 +19442,7 @@ - id: s_3220 - name: 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-16:1) - compartment: mm - - formula: C40H74O13P2 + - formula: C38H74O13P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -17966,7 +19450,7 @@ - id: s_3221 - name: 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-16:1) - compartment: mm - - formula: C40H72O13P2 + - formula: C38H72O13P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -17974,7 +19458,7 @@ - id: s_3222 - name: 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:0, 2-16:1) - compartment: mm - - formula: C42H76O13P2 + - formula: C40H78O13P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -17982,7 +19466,7 @@ - id: s_3223 - name: 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:1, 2-16:1) - compartment: mm - - formula: C42H74O13P2 + - formula: C40H76O13P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -17990,15 +19474,16 @@ - id: s_3224 - name: 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1) - compartment: mm - - formula: C42H76O13P2 + - formula: C40H78O13P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM725269 - sbo: SBO:0000247 - !!omap - id: s_3225 - name: 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-18:1) - compartment: mm - - formula: C42H74O13P2 + - formula: C40H76O13P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18009,6 +19494,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -18029,6 +19515,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -18082,9 +19569,10 @@ - id: s_3234 - name: cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1) - compartment: mm - - formula: C73H140O17P2 + - formula: C73H138O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM120766 - sbo: SBO:0000247 - !!omap - id: s_3235 @@ -18093,14 +19581,16 @@ - formula: C73H136O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM120775 - sbo: SBO:0000247 - !!omap - id: s_3236 - name: cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1) - compartment: mm - - formula: C75H144O17P2 + - formula: C75H142O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM120785 - sbo: SBO:0000247 - !!omap - id: s_3237 @@ -18109,14 +19599,16 @@ - formula: C75H140O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM120792 - sbo: SBO:0000247 - !!omap - id: s_3238 - name: cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1) - compartment: mm - - formula: C75H144O17P2 + - formula: C75H142O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM120768 - sbo: SBO:0000247 - !!omap - id: s_3239 @@ -18125,12 +19617,13 @@ - formula: C75H140O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM120778 - sbo: SBO:0000247 - !!omap - id: s_3240 - name: cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1) - compartment: mm - - formula: C73H138O17P2 + - formula: C73H136O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18141,13 +19634,15 @@ - formula: C73H134O17P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: clpn161 - chebi: CHEBI:104873 + - metanetx.chemical: MNXM4501 - sbo: SBO:0000247 - !!omap - id: s_3242 - name: cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1) - compartment: mm - - formula: C75H142O17P2 + - formula: C75H140O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18158,12 +19653,13 @@ - formula: C75H138O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM121254 - sbo: SBO:0000247 - !!omap - id: s_3244 - name: cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1) - compartment: mm - - formula: C75H142O17P2 + - formula: C75H140O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18174,12 +19670,13 @@ - formula: C75H138O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM121237 - sbo: SBO:0000247 - !!omap - id: s_3246 - name: cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-16:1) - compartment: mm - - formula: C75H144O17P2 + - formula: C75H142O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18195,7 +19692,7 @@ - id: s_3248 - name: cardiolipin (1-18:0, 2-16:1, 3-18:0, 4-16:1) - compartment: mm - - formula: C77H148O17P2 + - formula: C77H146O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18211,7 +19708,7 @@ - id: s_3250 - name: cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-18:1) - compartment: mm - - formula: C77H148O17P2 + - formula: C77H146O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18227,7 +19724,7 @@ - id: s_3252 - name: cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1) - compartment: mm - - formula: C75H142O17P2 + - formula: C75H140O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18243,7 +19740,7 @@ - id: s_3254 - name: cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1) - compartment: mm - - formula: C77H146O17P2 + - formula: C77H144O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18259,7 +19756,7 @@ - id: s_3256 - name: cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1) - compartment: mm - - formula: C77H146O17P2 + - formula: C77H144O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18275,7 +19772,7 @@ - id: s_3258 - name: cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-16:1) - compartment: mm - - formula: C75H144O17P2 + - formula: C75H142O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18286,12 +19783,13 @@ - formula: C75H140O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM120922 - sbo: SBO:0000247 - !!omap - id: s_3260 - name: cardiolipin (1-16:0, 2-18:1, 3-18:0, 4-16:1) - compartment: mm - - formula: C77H148O17P2 + - formula: C77H146O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18302,12 +19800,13 @@ - formula: C77H144O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM120940 - sbo: SBO:0000247 - !!omap - id: s_3262 - name: cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-18:1) - compartment: mm - - formula: C77H148O17P2 + - formula: C77H146O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18318,12 +19817,13 @@ - formula: C77H144O17P2 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM120924 - sbo: SBO:0000247 - !!omap - id: s_3264 - name: cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1) - compartment: mm - - formula: C75H142O17P2 + - formula: C75H140O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18339,7 +19839,7 @@ - id: s_3266 - name: cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1) - compartment: mm - - formula: C77H146O17P2 + - formula: C77H144O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18355,7 +19855,7 @@ - id: s_3268 - name: cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1) - compartment: mm - - formula: C77H146O17P2 + - formula: C77H144O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18382,6 +19882,7 @@ - formula: C16H31O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdca - chebi: CHEBI:7896 - kegg.compound: C00249 - metanetx.chemical: MNXM108 @@ -18433,6 +19934,7 @@ - formula: C18H35O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdca - chebi: CHEBI:25629 - kegg.compound: C01530 - metanetx.chemical: MNXM236 @@ -18594,9 +20096,13 @@ - id: s_3297 - name: 1-acylglycerophosphocholine (16:0) - compartment: mm - - formula: C24H51NO7P - - charge: 1 + - formula: C24H50NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc160 + - chebi: CHEBI:72998 + - kegg.compound: C04102 + - metanetx.chemical: MNXM32510 - sbo: SBO:0000247 - !!omap - id: s_3298 @@ -18605,49 +20111,63 @@ - formula: C40H76NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:134637 + - bigg.metabolite: pc161 + - chebi: CHEBI:83717 + - metanetx.chemical: MNXM69377 - sbo: SBO:0000247 - !!omap - id: s_3299 - name: 1-acylglycerophosphocholine (16:1) - compartment: mm - - formula: C24H49NO7P - - charge: 1 + - formula: C24H48NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc161 + - chebi: CHEBI:73851 + - metanetx.chemical: MNXM32519 - sbo: SBO:0000247 - !!omap - id: s_3300 - name: phosphatidylcholine (1-18:0, 2-16:1) - compartment: mm - - formula: C42H82NO7P + - formula: C42H82NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89972 + - chebi: CHEBI:86097 + - metanetx.chemical: MNXM69528 - sbo: SBO:0000247 - !!omap - id: s_3301 - name: 1-acylglycerophosphocholine (18:0) - compartment: mm - - formula: C26H55NO7P - - charge: 1 + - formula: C26H54NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc180 + - chebi: CHEBI:73858 + - metanetx.chemical: MNXM32545 - sbo: SBO:0000247 - !!omap - id: s_3302 - name: phosphatidylcholine (1-18:1, 2-16:1) - compartment: mm - - formula: C42H80NO7P + - formula: C42H80NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89506 + - chebi: CHEBI:86100 + - metanetx.chemical: MNXM69658 - sbo: SBO:0000247 - !!omap - id: s_3303 - name: 1-acylglycerophosphocholine (18:1) - compartment: mm - - formula: C26H53NO7P - - charge: 1 + - formula: C26H52NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc181 + - chebi: CHEBI:28610 + - kegg.compound: C03916 + - metanetx.chemical: MNXM13872 - sbo: SBO:0000247 - !!omap - id: s_3304 @@ -18665,31 +20185,34 @@ - formula: C42H80NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89668 + - chebi: CHEBI:84811 + - metanetx.chemical: MNXM69383 - sbo: SBO:0000247 - !!omap - id: s_3306 - name: phosphatidylcholine (1-18:0, 2-18:1) - compartment: mm - - formula: C44H86NO7P + - formula: C44H86NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89679 + - chebi: CHEBI:75034 + - metanetx.chemical: MNXM32526 - sbo: SBO:0000247 - !!omap - id: s_3307 - name: phosphatidylcholine (1-18:1, 2-18:1) - compartment: mm - - formula: C44H84NO7P + - formula: C44H84NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89504 + - chebi: CHEBI:74669 + - metanetx.chemical: MNXM8549 - sbo: SBO:0000247 - !!omap - id: s_3308 - name: cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1) - compartment: mm - - formula: C77H146O17P2 + - formula: C77H144O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18705,7 +20228,7 @@ - id: s_3310 - name: cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1) - compartment: mm - - formula: C79H150O17P2 + - formula: C79H148O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18721,7 +20244,7 @@ - id: s_3312 - name: cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1) - compartment: mm - - formula: C79H150O17P2 + - formula: C79H148O17P2 - charge: 0 - annotation: !!omap - sbo: SBO:0000247 @@ -18788,6 +20311,7 @@ - formula: C37H60N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: hdcoa - chebi: CHEBI:61540 - kegg.compound: C21072 - metanetx.chemical: MNXM781 @@ -18799,6 +20323,7 @@ - formula: C21H32N7O16P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: coa - chebi: CHEBI:57287 - kegg.compound: C00010 - metanetx.chemical: MNXM12 @@ -18810,6 +20335,7 @@ - formula: C39H64N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ocdce9coa - chebi: CHEBI:57387 - kegg.compound: C00510 - metanetx.chemical: MNXM686 @@ -18822,6 +20348,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88396 + - metanetx.chemical: MNXM75492 - sbo: SBO:0000247 - !!omap - id: s_3324 @@ -18830,6 +20357,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 - metanetx.chemical: MNXM7 @@ -18849,6 +20377,7 @@ - formula: C41H75O13P - charge: 0 - annotation: !!omap + - bigg.metabolite: pail161 - sbo: SBO:0000247 - !!omap - id: s_3327 @@ -18857,6 +20386,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail4p161 - sbo: SBO:0000247 - !!omap - id: s_3328 @@ -18866,6 +20396,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88557 + - metanetx.chemical: MNXM75665 - sbo: SBO:0000247 - !!omap - id: s_3329 @@ -18901,6 +20432,7 @@ - annotation: !!omap - chebi: CHEBI:73215 - kegg.compound: C13888 + - metanetx.chemical: MNXM75499 - sbo: SBO:0000247 - !!omap - id: s_3333 @@ -18935,6 +20467,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:77346 + - metanetx.chemical: MNXM75671 - sbo: SBO:0000247 - !!omap - id: s_3337 @@ -18970,6 +20503,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88396 + - metanetx.chemical: MNXM75492 - sbo: SBO:0000247 - !!omap - id: s_3341 @@ -18978,6 +20512,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -18989,6 +20524,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 - metanetx.chemical: MNXM7 @@ -19008,6 +20544,7 @@ - formula: C41H75O13P - charge: 0 - annotation: !!omap + - bigg.metabolite: pail161 - sbo: SBO:0000247 - !!omap - id: s_3345 @@ -19016,6 +20553,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail4p161 - sbo: SBO:0000247 - !!omap - id: s_3346 @@ -19025,6 +20563,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88557 + - metanetx.chemical: MNXM75665 - sbo: SBO:0000247 - !!omap - id: s_3347 @@ -19060,6 +20599,7 @@ - annotation: !!omap - chebi: CHEBI:73215 - kegg.compound: C13888 + - metanetx.chemical: MNXM75499 - sbo: SBO:0000247 - !!omap - id: s_3351 @@ -19094,6 +20634,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:77346 + - metanetx.chemical: MNXM75671 - sbo: SBO:0000247 - !!omap - id: s_3355 @@ -19129,6 +20670,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88396 + - metanetx.chemical: MNXM75492 - sbo: SBO:0000247 - !!omap - id: s_3359 @@ -19137,6 +20679,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -19148,6 +20691,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 - metanetx.chemical: MNXM7 @@ -19167,6 +20711,7 @@ - formula: C41H75O13P - charge: 0 - annotation: !!omap + - bigg.metabolite: pail161 - sbo: SBO:0000247 - !!omap - id: s_3363 @@ -19175,6 +20720,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail4p161 - sbo: SBO:0000247 - !!omap - id: s_3364 @@ -19184,6 +20730,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88557 + - metanetx.chemical: MNXM75665 - sbo: SBO:0000247 - !!omap - id: s_3365 @@ -19219,6 +20766,7 @@ - annotation: !!omap - chebi: CHEBI:73215 - kegg.compound: C13888 + - metanetx.chemical: MNXM75499 - sbo: SBO:0000247 - !!omap - id: s_3369 @@ -19253,6 +20801,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:77346 + - metanetx.chemical: MNXM75671 - sbo: SBO:0000247 - !!omap - id: s_3373 @@ -19288,6 +20837,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88396 + - metanetx.chemical: MNXM75492 - sbo: SBO:0000247 - !!omap - id: s_3377 @@ -19304,6 +20854,7 @@ - formula: C41H75O13P - charge: 0 - annotation: !!omap + - bigg.metabolite: pail161 - sbo: SBO:0000247 - !!omap - id: s_3379 @@ -19312,6 +20863,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail4p161 - sbo: SBO:0000247 - !!omap - id: s_3380 @@ -19321,6 +20873,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88557 + - metanetx.chemical: MNXM75665 - sbo: SBO:0000247 - !!omap - id: s_3381 @@ -19356,6 +20909,7 @@ - annotation: !!omap - chebi: CHEBI:73215 - kegg.compound: C13888 + - metanetx.chemical: MNXM75499 - sbo: SBO:0000247 - !!omap - id: s_3385 @@ -19390,6 +20944,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:77346 + - metanetx.chemical: MNXM75671 - sbo: SBO:0000247 - !!omap - id: s_3389 @@ -19432,6 +20987,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail3p161 - sbo: SBO:0000247 - !!omap - id: s_3394 @@ -19684,6 +21240,7 @@ - formula: C21H44NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe160 - chebi: CHEBI:90452 - sbo: SBO:0000247 - !!omap @@ -19693,6 +21250,7 @@ - formula: C21H42NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe161 - sbo: SBO:0000247 - !!omap - id: s_3426 @@ -19701,6 +21259,7 @@ - formula: C23H48NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe180 - chebi: CHEBI:64576 - sbo: SBO:0000247 - !!omap @@ -19710,39 +21269,54 @@ - formula: C23H46NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe181 - chebi: CHEBI:64575 - sbo: SBO:0000247 - !!omap - id: s_3428 - name: 1-acylglycerophosphocholine (16:0) - compartment: erm - - formula: C24H51NO7P - - charge: 1 + - formula: C24H50NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc160 + - chebi: CHEBI:72998 + - kegg.compound: C04102 + - metanetx.chemical: MNXM32510 - sbo: SBO:0000247 - !!omap - id: s_3429 - name: 1-acylglycerophosphocholine (16:1) - compartment: erm - - formula: C24H49NO7P - - charge: 1 + - formula: C24H48NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc161 + - chebi: CHEBI:73851 + - metanetx.chemical: MNXM32519 - sbo: SBO:0000247 - !!omap - id: s_3430 - name: 1-acylglycerophosphocholine (18:0) - compartment: erm - - formula: C26H55NO7P - - charge: 1 + - formula: C26H54NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc180 + - chebi: CHEBI:73858 + - metanetx.chemical: MNXM32545 - sbo: SBO:0000247 - !!omap - id: s_3431 - name: 1-acylglycerophosphocholine (18:1) - compartment: erm - - formula: C26H53NO7P - - charge: 1 + - formula: C26H52NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc181 + - chebi: CHEBI:28610 + - kegg.compound: C03916 + - metanetx.chemical: MNXM13872 - sbo: SBO:0000247 - !!omap - id: s_3432 @@ -19751,6 +21325,7 @@ - formula: C28H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: epist - chebi: CHEBI:23929 - kegg.compound: C15777 - metanetx.chemical: MNXM52365 @@ -19782,6 +21357,7 @@ - formula: C28H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: fecost - chebi: CHEBI:17038 - kegg.compound: C04525 - metanetx.chemical: MNXM1741 @@ -19813,6 +21389,7 @@ - formula: C30H50O - charge: 0 - annotation: !!omap + - bigg.metabolite: lanost - chebi: CHEBI:16521 - kegg.compound: C01724 - metanetx.chemical: MNXM482 @@ -19844,6 +21421,7 @@ - formula: C28H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: ergst - chebi: CHEBI:16933 - kegg.compound: C01694 - metanetx.chemical: MNXM922 @@ -19875,6 +21453,7 @@ - formula: C27H44O - charge: 0 - annotation: !!omap + - bigg.metabolite: zymst - chebi: CHEBI:18252 - kegg.compound: C05437 - metanetx.chemical: MNXM574 @@ -19906,6 +21485,7 @@ - formula: C8H20NO6P - charge: 0 - annotation: !!omap + - bigg.metabolite: g3pc - chebi: CHEBI:16870 - kegg.compound: C00670 - metanetx.chemical: MNXM367 @@ -19926,6 +21506,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -19934,9 +21515,13 @@ - id: s_3450 - name: 1-acylglycerophosphocholine (16:0) - compartment: ce - - formula: C24H51NO7P - - charge: 1 + - formula: C24H50NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc160 + - chebi: CHEBI:72998 + - kegg.compound: C04102 + - metanetx.chemical: MNXM32510 - sbo: SBO:0000247 - !!omap - id: s_3451 @@ -19945,6 +21530,7 @@ - formula: C16H29O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdcea - chebi: CHEBI:32372 - kegg.compound: C08362 - metanetx.chemical: MNXM162245 @@ -19956,49 +21542,63 @@ - formula: C40H76NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:134637 + - bigg.metabolite: pc161 + - chebi: CHEBI:83717 + - metanetx.chemical: MNXM69377 - sbo: SBO:0000247 - !!omap - id: s_3453 - name: 1-acylglycerophosphocholine (16:1) - compartment: ce - - formula: C24H49NO7P - - charge: 1 + - formula: C24H48NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc161 + - chebi: CHEBI:73851 + - metanetx.chemical: MNXM32519 - sbo: SBO:0000247 - !!omap - id: s_3454 - name: phosphatidylcholine (1-18:0, 2-16:1) - compartment: ce - - formula: C42H82NO7P + - formula: C42H82NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89972 + - chebi: CHEBI:86097 + - metanetx.chemical: MNXM69528 - sbo: SBO:0000247 - !!omap - id: s_3455 - name: 1-acylglycerophosphocholine (18:0) - compartment: ce - - formula: C26H55NO7P - - charge: 1 + - formula: C26H54NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc180 + - chebi: CHEBI:73858 + - metanetx.chemical: MNXM32545 - sbo: SBO:0000247 - !!omap - id: s_3456 - name: phosphatidylcholine (1-18:1, 2-16:1) - compartment: ce - - formula: C42H80NO7P + - formula: C42H80NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89506 + - chebi: CHEBI:86100 + - metanetx.chemical: MNXM69658 - sbo: SBO:0000247 - !!omap - id: s_3457 - name: 1-acylglycerophosphocholine (18:1) - compartment: ce - - formula: C26H53NO7P - - charge: 1 + - formula: C26H52NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc181 + - chebi: CHEBI:28610 + - kegg.compound: C03916 + - metanetx.chemical: MNXM13872 - sbo: SBO:0000247 - !!omap - id: s_3458 @@ -20016,6 +21616,7 @@ - formula: C18H33O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdcea - chebi: CHEBI:30823 - kegg.compound: C00712 - metanetx.chemical: MNXM306 @@ -20027,25 +21628,28 @@ - formula: C42H80NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89668 + - chebi: CHEBI:84811 + - metanetx.chemical: MNXM69383 - sbo: SBO:0000247 - !!omap - id: s_3461 - name: phosphatidylcholine (1-18:0, 2-18:1) - compartment: ce - - formula: C44H86NO7P + - formula: C44H86NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89679 + - chebi: CHEBI:75034 + - metanetx.chemical: MNXM32526 - sbo: SBO:0000247 - !!omap - id: s_3462 - name: phosphatidylcholine (1-18:1, 2-18:1) - compartment: ce - - formula: C44H84NO7P + - formula: C44H84NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89504 + - chebi: CHEBI:74669 + - metanetx.chemical: MNXM8549 - sbo: SBO:0000247 - !!omap - id: s_3463 @@ -20054,6 +21658,7 @@ - formula: C16H31O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: hdca - chebi: CHEBI:7896 - kegg.compound: C00249 - metanetx.chemical: MNXM108 @@ -20065,6 +21670,7 @@ - formula: C18H35O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdca - chebi: CHEBI:25629 - kegg.compound: C01530 - metanetx.chemical: MNXM236 @@ -20085,6 +21691,7 @@ - formula: C21H44NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe160 - chebi: CHEBI:90452 - sbo: SBO:0000247 - !!omap @@ -20094,6 +21701,7 @@ - formula: C37H70NO8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pe161 - chebi: CHEBI:138792 - sbo: SBO:0000247 - !!omap @@ -20103,6 +21711,7 @@ - formula: C21H42NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe161 - sbo: SBO:0000247 - !!omap - id: s_3469 @@ -20120,6 +21729,7 @@ - formula: C23H48NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe180 - chebi: CHEBI:64576 - sbo: SBO:0000247 - !!omap @@ -20130,6 +21740,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:82837 + - metanetx.chemical: MNXM71684 - sbo: SBO:0000247 - !!omap - id: s_3472 @@ -20138,6 +21749,7 @@ - formula: C23H46NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe181 - chebi: CHEBI:64575 - sbo: SBO:0000247 - !!omap @@ -20183,6 +21795,7 @@ - formula: C5H14NO6P - charge: 0 - annotation: !!omap + - bigg.metabolite: g3pe - chebi: CHEBI:16929 - kegg.compound: C01233 - metanetx.chemical: MNXM368 @@ -20195,14 +21808,16 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89824 + - metanetx.chemical: MNXM78605 - sbo: SBO:0000247 - !!omap - id: s_3479 - name: 1-acylglycerophosphoserine (16:0) - compartment: ce - - formula: C22H44NP10 + - formula: C22H44NO9P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM78597 - sbo: SBO:0000247 - !!omap - id: s_3480 @@ -20211,14 +21826,16 @@ - formula: C38H70NO10P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM78637 - sbo: SBO:0000247 - !!omap - id: s_3481 - name: 1-acylglycerophosphoserine (16:1) - compartment: ce - - formula: C22H42NP10 + - formula: C22H42NO9P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM78629 - sbo: SBO:0000247 - !!omap - id: s_3482 @@ -20228,14 +21845,17 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90036 + - metanetx.chemical: MNXM78765 - sbo: SBO:0000247 - !!omap - id: s_3483 - name: 1-acylglycerophosphoserine (18:0) - compartment: ce - - formula: C24H48NP10 + - formula: C24H48NO9P - charge: 0 - annotation: !!omap + - chebi: CHEBI:85403 + - metanetx.chemical: MNXM78757 - sbo: SBO:0000247 - !!omap - id: s_3484 @@ -20245,14 +21865,17 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75101 + - metanetx.chemical: MNXM78797 - sbo: SBO:0000247 - !!omap - id: s_3485 - name: 1-acylglycerophosphoserine (18:1) - compartment: ce - - formula: C24H46NP10 + - formula: C24H46NO9P - charge: 0 - annotation: !!omap + - chebi: CHEBI:52649 + - metanetx.chemical: MNXM32944 - sbo: SBO:0000247 - !!omap - id: s_3486 @@ -20261,7 +21884,9 @@ - formula: C40H76NO10P - charge: 0 - annotation: !!omap - - chebi: CHEBI:134541 + - chebi: CHEBI:34086 + - kegg.compound: C13880 + - metanetx.chemical: MNXM32501 - sbo: SBO:0000247 - !!omap - id: s_3487 @@ -20271,6 +21896,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:90032 + - metanetx.chemical: MNXM78642 - sbo: SBO:0000247 - !!omap - id: s_3488 @@ -20279,7 +21905,8 @@ - formula: C42H80NO10P - charge: 0 - annotation: !!omap - - chebi: CHEBI:90433 + - chebi: CHEBI:79096 + - metanetx.chemical: MNXM32529 - sbo: SBO:0000247 - !!omap - id: s_3489 @@ -20289,6 +21916,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:60568 + - metanetx.chemical: MNXM32173 - sbo: SBO:0000247 - !!omap - id: s_3490 @@ -20297,6 +21925,7 @@ - formula: C6H14NO8P - charge: 0 - annotation: !!omap + - bigg.metabolite: g3ps - chebi: CHEBI:64945 - sbo: SBO:0000247 - !!omap @@ -20306,6 +21935,7 @@ - formula: C25H49O12P - charge: 0 - annotation: !!omap + - bigg.metabolite: pailpalm_hs - chebi: CHEBI:73218 - sbo: SBO:0000247 - !!omap @@ -20324,6 +21954,7 @@ - formula: C27H53O12P - charge: 0 - annotation: !!omap + - bigg.metabolite: pailste_hs - chebi: CHEBI:83054 - sbo: SBO:0000247 - !!omap @@ -20342,6 +21973,7 @@ - formula: C9H18O11P - charge: -1 - annotation: !!omap + - bigg.metabolite: g3pi - chebi: CHEBI:58444 - kegg.compound: C01225 - metanetx.chemical: MNXM1517 @@ -20358,10 +21990,11 @@ - id: s_3497 - name: diglyceride (1-16:0, 2-16:1) - compartment: c - - formula: C35H68O5 + - formula: C35H66O5 - charge: 0 - annotation: !!omap - - chebi: CHEBI:82929 + - chebi: CHEBI:84394 + - metanetx.chemical: MNXM49375 - sbo: SBO:0000247 - !!omap - id: s_3498 @@ -20370,6 +22003,7 @@ - formula: C6H9O15P3 - charge: -6 - annotation: !!omap + - bigg.metabolite: mi145p - chebi: CHEBI:203600 - kegg.compound: C01245 - metanetx.chemical: MNXM200 @@ -20389,7 +22023,9 @@ - formula: C35H64O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr161 - chebi: CHEBI:84417 + - metanetx.chemical: MNXM176611 - sbo: SBO:0000247 - !!omap - id: s_3501 @@ -20407,6 +22043,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88527 + - metanetx.chemical: MNXM49511 - sbo: SBO:0000247 - !!omap - id: s_3503 @@ -20424,6 +22061,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89229 + - metanetx.chemical: MNXM49575 - sbo: SBO:0000247 - !!omap - id: s_3505 @@ -20441,6 +22079,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88454 + - metanetx.chemical: MNXM49380 - sbo: SBO:0000247 - !!omap - id: s_3507 @@ -20458,6 +22097,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88500 + - metanetx.chemical: MNXM49417 - sbo: SBO:0000247 - !!omap - id: s_3509 @@ -20476,6 +22116,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75468 + - metanetx.chemical: MNXM49514 - sbo: SBO:0000247 - !!omap - id: s_3511 @@ -20492,16 +22133,19 @@ - formula: C39H72O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr181 - chebi: CHEBI:52333 + - metanetx.chemical: MNXM9533 - sbo: SBO:0000247 - !!omap - id: s_3513 - name: diglyceride (1-16:0, 2-16:1) - compartment: n - - formula: C35H68O5 + - formula: C35H66O5 - charge: 0 - annotation: !!omap - - chebi: CHEBI:82929 + - chebi: CHEBI:84394 + - metanetx.chemical: MNXM49375 - sbo: SBO:0000247 - !!omap - id: s_3514 @@ -20510,7 +22154,9 @@ - formula: C35H64O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr161 - chebi: CHEBI:84417 + - metanetx.chemical: MNXM176611 - sbo: SBO:0000247 - !!omap - id: s_3515 @@ -20520,6 +22166,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88527 + - metanetx.chemical: MNXM49511 - sbo: SBO:0000247 - !!omap - id: s_3516 @@ -20529,6 +22176,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89229 + - metanetx.chemical: MNXM49575 - sbo: SBO:0000247 - !!omap - id: s_3517 @@ -20538,6 +22186,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88454 + - metanetx.chemical: MNXM49380 - sbo: SBO:0000247 - !!omap - id: s_3518 @@ -20547,6 +22196,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88500 + - metanetx.chemical: MNXM49417 - sbo: SBO:0000247 - !!omap - id: s_3519 @@ -20556,6 +22206,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75468 + - metanetx.chemical: MNXM49514 - sbo: SBO:0000247 - !!omap - id: s_3520 @@ -20564,16 +22215,19 @@ - formula: C39H72O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr181 - chebi: CHEBI:52333 + - metanetx.chemical: MNXM9533 - sbo: SBO:0000247 - !!omap - id: s_3521 - name: diglyceride (1-16:0, 2-16:1) - compartment: mm - - formula: C35H68O5 + - formula: C35H66O5 - charge: 0 - annotation: !!omap - - chebi: CHEBI:82929 + - chebi: CHEBI:84394 + - metanetx.chemical: MNXM49375 - sbo: SBO:0000247 - !!omap - id: s_3522 @@ -20582,7 +22236,9 @@ - formula: C35H64O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr161 - chebi: CHEBI:84417 + - metanetx.chemical: MNXM176611 - sbo: SBO:0000247 - !!omap - id: s_3523 @@ -20592,6 +22248,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88527 + - metanetx.chemical: MNXM49511 - sbo: SBO:0000247 - !!omap - id: s_3524 @@ -20601,6 +22258,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:89229 + - metanetx.chemical: MNXM49575 - sbo: SBO:0000247 - !!omap - id: s_3525 @@ -20610,6 +22268,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88454 + - metanetx.chemical: MNXM49380 - sbo: SBO:0000247 - !!omap - id: s_3526 @@ -20619,15 +22278,17 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88500 + - metanetx.chemical: MNXM49417 - sbo: SBO:0000247 - !!omap - id: s_3527 - name: phosphatidate (1-16:0, 2-16:1) - compartment: ce - - formula: C35H65O8P - - charge: -2 + - formula: C35H67O8P + - charge: 0 - annotation: !!omap - chebi: CHEBI:73998 + - metanetx.chemical: MNXM66470 - sbo: SBO:0000247 - !!omap - id: s_3528 @@ -20636,7 +22297,9 @@ - formula: C35H65O8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pa161 - chebi: CHEBI:75071 + - metanetx.chemical: MNXM66504 - sbo: SBO:0000247 - !!omap - id: s_3529 @@ -20646,6 +22309,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75073 + - metanetx.chemical: MNXM66631 - sbo: SBO:0000247 - !!omap - id: s_3530 @@ -20655,6 +22319,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75074 + - metanetx.chemical: MNXM66663 - sbo: SBO:0000247 - !!omap - id: s_3531 @@ -20674,6 +22339,7 @@ - formula: C37H69O8P - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM66509 - sbo: SBO:0000247 - !!omap - id: s_3533 @@ -20683,6 +22349,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:74847 + - metanetx.chemical: MNXM66635 - sbo: SBO:0000247 - !!omap - id: s_3534 @@ -20692,6 +22359,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:83775 + - metanetx.chemical: MNXM51075 - sbo: SBO:0000247 - !!omap - id: s_3535 @@ -20708,6 +22376,7 @@ - formula: HO4P - charge: -2 - annotation: !!omap + - bigg.metabolite: pi - chebi: CHEBI:43474 - kegg.compound: C00009 - metanetx.chemical: MNXM9 @@ -20719,6 +22388,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail3p161 - sbo: SBO:0000247 - !!omap - id: s_3538 @@ -20786,6 +22456,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88396 + - metanetx.chemical: MNXM75492 - sbo: SBO:0000247 - !!omap - id: s_3546 @@ -20794,6 +22465,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail3p161 - sbo: SBO:0000247 - !!omap - id: s_3547 @@ -20802,6 +22474,7 @@ - formula: C41H75O13P - charge: 0 - annotation: !!omap + - bigg.metabolite: pail161 - sbo: SBO:0000247 - !!omap - id: s_3548 @@ -20819,6 +22492,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88557 + - metanetx.chemical: MNXM75665 - sbo: SBO:0000247 - !!omap - id: s_3550 @@ -20854,6 +22528,7 @@ - annotation: !!omap - chebi: CHEBI:73215 - kegg.compound: C13888 + - metanetx.chemical: MNXM75499 - sbo: SBO:0000247 - !!omap - id: s_3554 @@ -20889,6 +22564,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:77346 + - metanetx.chemical: MNXM75671 - sbo: SBO:0000247 - !!omap - id: s_3558 @@ -20923,6 +22599,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail3p161 - sbo: SBO:0000247 - !!omap - id: s_3562 @@ -20989,6 +22666,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail3p161 - sbo: SBO:0000247 - !!omap - id: s_3570 @@ -21055,6 +22733,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail4p161 - sbo: SBO:0000247 - !!omap - id: s_3578 @@ -21120,6 +22799,7 @@ - formula: C41H76O16P2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pail4p161 - sbo: SBO:0000247 - !!omap - id: s_3586 @@ -21502,6 +23182,7 @@ - formula: C19H39O7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1hdecg3p - chebi: CHEBI:15799 - kegg.compound: C04036 - metanetx.chemical: MNXM2455 @@ -21513,6 +23194,7 @@ - formula: C19H38O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: mag160 - chebi: CHEBI:134127 - sbo: SBO:0000247 - !!omap @@ -21523,6 +23205,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75070 + - metanetx.chemical: MNXM66496 - sbo: SBO:0000247 - !!omap - id: s_3635 @@ -21540,7 +23223,9 @@ - formula: C21H43O7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1odecg3p - chebi: CHEBI:74850 + - metanetx.chemical: MNXM32950 - sbo: SBO:0000247 - !!omap - id: s_3637 @@ -21549,6 +23234,7 @@ - formula: C21H42O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: mag180 - chebi: CHEBI:134129 - sbo: SBO:0000247 - !!omap @@ -21559,6 +23245,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:62837 + - metanetx.chemical: MNXM32960 - sbo: SBO:0000247 - !!omap - id: s_3639 @@ -21567,6 +23254,7 @@ - formula: C21H40O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: magole_hs - chebi: CHEBI:134130 - sbo: SBO:0000247 - !!omap @@ -21576,6 +23264,7 @@ - formula: C19H39O7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1hdecg3p - chebi: CHEBI:15799 - kegg.compound: C04036 - metanetx.chemical: MNXM2455 @@ -21587,6 +23276,7 @@ - formula: C19H38O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: mag160 - chebi: CHEBI:134127 - sbo: SBO:0000247 - !!omap @@ -21597,6 +23287,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75070 + - metanetx.chemical: MNXM66496 - sbo: SBO:0000247 - !!omap - id: s_3643 @@ -21614,7 +23305,9 @@ - formula: C21H43O7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1odecg3p - chebi: CHEBI:74850 + - metanetx.chemical: MNXM32950 - sbo: SBO:0000247 - !!omap - id: s_3645 @@ -21623,6 +23316,7 @@ - formula: C21H42O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: mag180 - chebi: CHEBI:134129 - sbo: SBO:0000247 - !!omap @@ -21633,6 +23327,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:62837 + - metanetx.chemical: MNXM32960 - sbo: SBO:0000247 - !!omap - id: s_3647 @@ -21641,6 +23336,7 @@ - formula: C21H40O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: magole_hs - chebi: CHEBI:134130 - sbo: SBO:0000247 - !!omap @@ -21650,6 +23346,7 @@ - formula: C19H39O7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1hdecg3p - chebi: CHEBI:15799 - kegg.compound: C04036 - metanetx.chemical: MNXM2455 @@ -21661,6 +23358,7 @@ - formula: C19H38O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: mag160 - chebi: CHEBI:134127 - sbo: SBO:0000247 - !!omap @@ -21671,6 +23369,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75070 + - metanetx.chemical: MNXM66496 - sbo: SBO:0000247 - !!omap - id: s_3651 @@ -21688,7 +23387,9 @@ - formula: C21H43O7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1odecg3p - chebi: CHEBI:74850 + - metanetx.chemical: MNXM32950 - sbo: SBO:0000247 - !!omap - id: s_3653 @@ -21697,6 +23398,7 @@ - formula: C21H42O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: mag180 - chebi: CHEBI:134129 - sbo: SBO:0000247 - !!omap @@ -21707,6 +23409,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:62837 + - metanetx.chemical: MNXM32960 - sbo: SBO:0000247 - !!omap - id: s_3655 @@ -21715,6 +23418,7 @@ - formula: C21H40O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: magole_hs - chebi: CHEBI:134130 - sbo: SBO:0000247 - !!omap @@ -21734,6 +23438,7 @@ - formula: H2O - charge: 0 - annotation: !!omap + - bigg.metabolite: h2o - chebi: CHEBI:15377 - kegg.compound: C00001 - metanetx.chemical: MNXM2 @@ -21765,6 +23470,7 @@ - formula: C28H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: epist - chebi: CHEBI:23929 - kegg.compound: C15777 - metanetx.chemical: MNXM52365 @@ -21816,6 +23522,7 @@ - formula: C30H50O - charge: 0 - annotation: !!omap + - bigg.metabolite: lanost - chebi: CHEBI:16521 - kegg.compound: C01724 - metanetx.chemical: MNXM482 @@ -21877,6 +23584,7 @@ - formula: C19H38O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: mag160 - chebi: CHEBI:134127 - sbo: SBO:0000247 - !!omap @@ -21895,6 +23603,7 @@ - formula: C21H42O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: mag180 - chebi: CHEBI:134129 - sbo: SBO:0000247 - !!omap @@ -21904,6 +23613,7 @@ - formula: C21H40O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: magole_hs - chebi: CHEBI:134130 - sbo: SBO:0000247 - !!omap @@ -21914,6 +23624,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88454 + - metanetx.chemical: MNXM49380 - sbo: SBO:0000247 - !!omap - id: s_3676 @@ -21922,6 +23633,7 @@ - formula: C19H38O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: mag160 - chebi: CHEBI:134127 - sbo: SBO:0000247 - !!omap @@ -21931,6 +23643,7 @@ - formula: C18H33O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: ocdcea - chebi: CHEBI:30823 - kegg.compound: C00712 - metanetx.chemical: MNXM306 @@ -21943,6 +23656,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:88500 + - metanetx.chemical: MNXM49417 - sbo: SBO:0000247 - !!omap - id: s_3679 @@ -21961,6 +23675,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75468 + - metanetx.chemical: MNXM49514 - sbo: SBO:0000247 - !!omap - id: s_3681 @@ -21969,6 +23684,7 @@ - formula: C21H42O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: mag180 - chebi: CHEBI:134129 - sbo: SBO:0000247 - !!omap @@ -21978,7 +23694,9 @@ - formula: C39H72O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 12dgr181 - chebi: CHEBI:52333 + - metanetx.chemical: MNXM9533 - sbo: SBO:0000247 - !!omap - id: s_3683 @@ -21987,6 +23705,7 @@ - formula: C21H40O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: magole_hs - chebi: CHEBI:134130 - sbo: SBO:0000247 - !!omap @@ -21996,6 +23715,7 @@ - formula: C3H8O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: glyc - chebi: CHEBI:17754 - kegg.compound: C00116 - metanetx.chemical: MNXM89612 @@ -22007,6 +23727,7 @@ - formula: C21H44NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe160 - chebi: CHEBI:90452 - sbo: SBO:0000247 - !!omap @@ -22025,6 +23746,7 @@ - formula: C21H42NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe161 - sbo: SBO:0000247 - !!omap - id: s_3688 @@ -22042,6 +23764,7 @@ - formula: C23H48NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe180 - chebi: CHEBI:64576 - sbo: SBO:0000247 - !!omap @@ -22060,6 +23783,7 @@ - formula: C23H46NO7P - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpe181 - chebi: CHEBI:64575 - sbo: SBO:0000247 - !!omap @@ -22084,9 +23808,13 @@ - id: s_3694 - name: 1-acylglycerophosphocholine (16:0) - compartment: lp - - formula: C24H51NO7P - - charge: 1 + - formula: C24H50NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc160 + - chebi: CHEBI:72998 + - kegg.compound: C04102 + - metanetx.chemical: MNXM32510 - sbo: SBO:0000247 - !!omap - id: s_3695 @@ -22095,49 +23823,63 @@ - formula: C40H76NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:134637 + - bigg.metabolite: pc161 + - chebi: CHEBI:83717 + - metanetx.chemical: MNXM69377 - sbo: SBO:0000247 - !!omap - id: s_3696 - name: 1-acylglycerophosphocholine (16:1) - compartment: lp - - formula: C24H49NO7P - - charge: 1 + - formula: C24H48NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc161 + - chebi: CHEBI:73851 + - metanetx.chemical: MNXM32519 - sbo: SBO:0000247 - !!omap - id: s_3697 - name: phosphatidylcholine (1-18:0, 2-16:1) - compartment: lp - - formula: C42H82NO7P + - formula: C42H82NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89972 + - chebi: CHEBI:86097 + - metanetx.chemical: MNXM69528 - sbo: SBO:0000247 - !!omap - id: s_3698 - name: 1-acylglycerophosphocholine (18:0) - compartment: lp - - formula: C26H55NO7P - - charge: 1 + - formula: C26H54NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc180 + - chebi: CHEBI:73858 + - metanetx.chemical: MNXM32545 - sbo: SBO:0000247 - !!omap - id: s_3699 - name: phosphatidylcholine (1-18:1, 2-16:1) - compartment: lp - - formula: C42H80NO7P + - formula: C42H80NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89506 + - chebi: CHEBI:86100 + - metanetx.chemical: MNXM69658 - sbo: SBO:0000247 - !!omap - id: s_3700 - name: 1-acylglycerophosphocholine (18:1) - compartment: lp - - formula: C26H53NO7P - - charge: 1 + - formula: C26H52NO7P + - charge: 0 - annotation: !!omap + - bigg.metabolite: 1agpc181 + - chebi: CHEBI:28610 + - kegg.compound: C03916 + - metanetx.chemical: MNXM13872 - sbo: SBO:0000247 - !!omap - id: s_3701 @@ -22155,25 +23897,28 @@ - formula: C42H80NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89668 + - chebi: CHEBI:84811 + - metanetx.chemical: MNXM69383 - sbo: SBO:0000247 - !!omap - id: s_3703 - name: phosphatidylcholine (1-18:0, 2-18:1) - compartment: lp - - formula: C44H86NO7P + - formula: C44H86NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89679 + - chebi: CHEBI:75034 + - metanetx.chemical: MNXM32526 - sbo: SBO:0000247 - !!omap - id: s_3704 - name: phosphatidylcholine (1-18:1, 2-18:1) - compartment: lp - - formula: C44H84NO7P + - formula: C44H84NO8P - charge: 0 - annotation: !!omap - - chebi: CHEBI:89504 + - chebi: CHEBI:74669 + - metanetx.chemical: MNXM8549 - sbo: SBO:0000247 - !!omap - id: s_3705 @@ -22191,6 +23936,7 @@ - formula: C37H70NO8P - charge: 0 - annotation: !!omap + - bigg.metabolite: pe161 - chebi: CHEBI:138792 - sbo: SBO:0000247 - !!omap @@ -22210,6 +23956,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:82837 + - metanetx.chemical: MNXM71684 - sbo: SBO:0000247 - !!omap - id: s_3709 @@ -22227,6 +23974,8 @@ - formula: C6H10NO6P - charge: 0 - annotation: !!omap + - bigg.metabolite: ps_cho + - kegg.compound: C02737 - metanetx.chemical: MNXM221 - sbo: SBO:0000649 - !!omap @@ -22236,6 +23985,8 @@ - formula: C8H16NO3P - charge: 1 - annotation: !!omap + - bigg.metabolite: pchol_cho + - kegg.compound: C00157 - metanetx.chemical: MNXM96952 - sbo: SBO:0000649 - !!omap @@ -22245,6 +23996,8 @@ - formula: C5H10NO4P - charge: 0 - annotation: !!omap + - bigg.metabolite: pe_hs + - kegg.compound: C00350 - metanetx.chemical: MNXM115 - sbo: SBO:0000649 - !!omap @@ -22254,15 +24007,18 @@ - formula: C3H2 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag_cho + - kegg.compound: C00422 - metanetx.chemical: MNXM248 - sbo: SBO:0000649 - !!omap - id: s_3714 - name: heme a - compartment: c - - formula: C49H56FeN4O6 - - charge: 0 + - formula: C49H55FeN4O6 + - charge: -3 - annotation: !!omap + - bigg.metabolite: hemeA - chebi: CHEBI:24479 - kegg.compound: C15670 - metanetx.chemical: MNXM53309 @@ -22274,6 +24030,7 @@ - formula: C18H32O16 - charge: 0 - annotation: !!omap + - bigg.metabolite: raffin - chebi: CHEBI:16634 - kegg.compound: C00492 - metanetx.chemical: MNXM621 @@ -22285,6 +24042,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: melib - chebi: CHEBI:28053 - kegg.compound: C05402 - metanetx.chemical: MNXM1434 @@ -22294,6 +24052,8 @@ - name: protein - compartment: c - annotation: !!omap + - bigg.metabolite: protein + - kegg.compound: C00492 - metanetx.chemical: MNXM621 - sbo: SBO:0000649 - !!omap @@ -22301,6 +24061,7 @@ - name: carbohydrate - compartment: c - annotation: !!omap + - kegg.compound: C05402 - metanetx.chemical: MNXM1434 - sbo: SBO:0000649 - !!omap @@ -22308,12 +24069,14 @@ - name: RNA - compartment: c - annotation: !!omap + - bigg.metabolite: rna - sbo: SBO:0000649 - !!omap - id: s_3720 - name: DNA - compartment: c - annotation: !!omap + - bigg.metabolite: dna - sbo: SBO:0000649 - !!omap - id: s_3721 @@ -22509,6 +24272,7 @@ - formula: C40H40FeN6O6S2 - charge: -2 - annotation: !!omap + - bigg.metabolite: cytc - chebi: CHEBI:83739 - kegg.compound: C00524 - sbo: SBO:0000247 @@ -22519,6 +24283,7 @@ - formula: C6H10N2O2S2 - charge: 0 - annotation: !!omap + - bigg.metabolite: apocytc - chebi: CHEBI:15697 - kegg.compound: C02248 - metanetx.chemical: MNXM2100 @@ -22530,6 +24295,7 @@ - formula: C4H6O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: diact - chebi: CHEBI:16583 - kegg.compound: C00741 - metanetx.chemical: MNXM1467 @@ -22541,6 +24307,7 @@ - formula: C4H8O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: actn__R - chebi: CHEBI:15686 - kegg.compound: C00810 - metanetx.chemical: MNXM664 @@ -22552,6 +24319,7 @@ - formula: C4H6O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: diact - chebi: CHEBI:16583 - kegg.compound: C00741 - metanetx.chemical: MNXM1467 @@ -22563,6 +24331,7 @@ - formula: C21H27N7O14P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: nadh - chebi: CHEBI:57945 - kegg.compound: C00004 - metanetx.chemical: MNXM10 @@ -22571,9 +24340,10 @@ - id: s_3754 - name: L-glutamyl-tRNA(Gln) - compartment: m - - formula: C20H28N6O13PR + - formula: C5H8NO3R - charge: 0 - annotation: !!omap + - bigg.metabolite: glutrna_gln - chebi: CHEBI:29165 - kegg.compound: C06112 - metanetx.chemical: MNXM91213 @@ -22585,6 +24355,7 @@ - formula: C5H10N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: gln__L - chebi: CHEBI:18050 - kegg.compound: C00064 - metanetx.chemical: MNXM37 @@ -22593,9 +24364,10 @@ - id: s_3756 - name: Gln-tRNA(Gln) - compartment: m - - formula: C20H29N7O12PR - - charge: 0 + - formula: C5H10N2O2R + - charge: 1 - annotation: !!omap + - bigg.metabolite: glntrna - chebi: CHEBI:29166 - kegg.compound: C02282 - metanetx.chemical: MNXM89810 @@ -22607,7 +24379,9 @@ - formula: C8H16N2O3S - charge: 0 - annotation: !!omap + - bigg.metabolite: met_L_ala__L - chebi: CHEBI:73610 + - metanetx.chemical: MNXM61647 - sbo: SBO:0000247 - !!omap - id: s_3758 @@ -22616,6 +24390,7 @@ - formula: C5H11NO2S - charge: 0 - annotation: !!omap + - bigg.metabolite: met__L - chebi: CHEBI:16643 - kegg.compound: C00073 - metanetx.chemical: MNXM61 @@ -22627,6 +24402,7 @@ - formula: C3H7NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala__L - chebi: CHEBI:16977 - kegg.compound: C00041 - metanetx.chemical: MNXM32 @@ -22639,6 +24415,7 @@ - charge: -4 - annotation: !!omap - chebi: CHEBI:58753 + - metanetx.chemical: MNXM5039 - sbo: SBO:0000247 - !!omap - id: s_3761 @@ -22647,6 +24424,7 @@ - formula: C15H21N5O14P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: adprib - chebi: CHEBI:57967 - kegg.compound: C00301 - metanetx.chemical: MNXM48596 @@ -22670,6 +24448,8 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:17977 + - kegg.compound: C02389 + - metanetx.chemical: MNXM7107 - sbo: SBO:0000247 - !!omap - id: s_3764 @@ -22678,6 +24458,7 @@ - formula: C17H25N3O17P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: uacgam - chebi: CHEBI:57705 - kegg.compound: C00043 - metanetx.chemical: MNXM47 @@ -22689,6 +24470,7 @@ - formula: C28H51NO12P2R - charge: 0 - annotation: !!omap + - bigg.metabolite: naglc2p - chebi: CHEBI:18278 - kegg.compound: C04500 - metanetx.chemical: MNXM818 @@ -22700,6 +24482,7 @@ - formula: C9H11N2O12P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: udp - chebi: CHEBI:58223 - kegg.compound: C00015 - metanetx.chemical: MNXM17 @@ -22720,6 +24503,8 @@ - charge: -2 - annotation: !!omap - chebi: CHEBI:78346 + - kegg.compound: C00117 + - metanetx.chemical: MNXM722712 - sbo: SBO:0000247 - !!omap - id: s_3769 @@ -22728,6 +24513,7 @@ - formula: C2O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: oxa - chebi: CHEBI:30623 - kegg.compound: C00209 - metanetx.chemical: MNXM291 @@ -22739,6 +24525,7 @@ - formula: C23H31N7O19P3S - charge: -5 - annotation: !!omap + - bigg.metabolite: oxalcoa - chebi: CHEBI:57388 - kegg.compound: C00313 - metanetx.chemical: MNXM618 @@ -22758,6 +24545,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: glc__D - chebi: CHEBI:4167 - kegg.compound: C00031 - metanetx.chemical: MNXM41 @@ -22777,6 +24565,7 @@ - formula: C74H122N4O57R - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM6479 - sbo: SBO:0000247 - !!omap - id: s_3775 @@ -22785,6 +24574,7 @@ - formula: Na - charge: 1 - annotation: !!omap + - bigg.metabolite: na1 - chebi: CHEBI:29101 - kegg.compound: C01330 - metanetx.chemical: MNXM27 @@ -22796,6 +24586,7 @@ - formula: K - charge: 1 - annotation: !!omap + - bigg.metabolite: k - chebi: CHEBI:29103 - kegg.compound: C00238 - metanetx.chemical: MNXM95 @@ -22807,6 +24598,7 @@ - formula: Cl - charge: -1 - annotation: !!omap + - bigg.metabolite: cl - chebi: CHEBI:17996 - kegg.compound: C00698 - metanetx.chemical: MNXM43 @@ -22818,6 +24610,7 @@ - formula: Cl - charge: -1 - annotation: !!omap + - bigg.metabolite: cl - chebi: CHEBI:17996 - kegg.compound: C00698 - metanetx.chemical: MNXM43 @@ -22829,6 +24622,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: fru - chebi: CHEBI:15824 - kegg.compound: C00095 - metanetx.chemical: MNXM175 @@ -22840,6 +24634,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: gal - chebi: CHEBI:4139 - kegg.compound: C00124 - metanetx.chemical: MNXM390 @@ -22851,6 +24646,7 @@ - formula: C9H11N2O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: ump - chebi: CHEBI:57865 - kegg.compound: C00105 - metanetx.chemical: MNXM80 @@ -22862,7 +24658,10 @@ - formula: Cd - charge: 2 - annotation: !!omap + - bigg.metabolite: cd2 - chebi: CHEBI:48775 + - kegg.compound: C01413 + - metanetx.chemical: MNXM4505 - sbo: SBO:0000247 - !!omap - id: s_3783 @@ -22871,7 +24670,10 @@ - formula: Cd - charge: 2 - annotation: !!omap + - bigg.metabolite: cd2 - chebi: CHEBI:48775 + - kegg.compound: C01413 + - metanetx.chemical: MNXM4505 - sbo: SBO:0000247 - !!omap - id: s_3784 @@ -22888,6 +24690,7 @@ - formula: C3H7NO2S - charge: 0 - annotation: !!omap + - bigg.metabolite: cys__L - chebi: CHEBI:17561 - kegg.compound: C00097 - metanetx.chemical: MNXM55 @@ -22907,6 +24710,7 @@ - formula: C27H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: chsterol - chebi: CHEBI:16113 - kegg.compound: C00187 - metanetx.chemical: MNXM103 @@ -22918,6 +24722,7 @@ - formula: C27H46O - charge: 0 - annotation: !!omap + - bigg.metabolite: chsterol - chebi: CHEBI:16113 - kegg.compound: C00187 - metanetx.chemical: MNXM103 @@ -22967,6 +24772,7 @@ - formula: C8H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 3mbzalc - chebi: CHEBI:27995 - kegg.compound: C07216 - metanetx.chemical: MNXM3486 @@ -22978,6 +24784,7 @@ - formula: C8H8O - charge: 0 - annotation: !!omap + - bigg.metabolite: 3mbzald - chebi: CHEBI:28476 - kegg.compound: C07209 - metanetx.chemical: MNXM4040 @@ -22990,6 +24797,8 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:27628 + - kegg.compound: C06576 + - metanetx.chemical: MNXM5878 - sbo: SBO:0000247 - !!omap - id: s_3796 @@ -23009,6 +24818,7 @@ - formula: C8H10O - charge: 0 - annotation: !!omap + - bigg.metabolite: 4mbzalc - chebi: CHEBI:1895 - kegg.compound: C06757 - metanetx.chemical: MNXM3500 @@ -23020,6 +24830,7 @@ - formula: C8H8O - charge: 0 - annotation: !!omap + - bigg.metabolite: 4mbzald - chebi: CHEBI:28617 - kegg.compound: C06758 - metanetx.chemical: MNXM4077 @@ -23031,6 +24842,7 @@ - formula: C7H8O - charge: 0 - annotation: !!omap + - bigg.metabolite: bzalc - chebi: CHEBI:17987 - kegg.compound: C00556 - metanetx.chemical: MNXM562 @@ -23042,6 +24854,7 @@ - formula: C7H6O - charge: 0 - annotation: !!omap + - bigg.metabolite: bzal - chebi: CHEBI:17169 - kegg.compound: C00261 - metanetx.chemical: MNXM371 @@ -23053,6 +24866,7 @@ - formula: Mn - charge: 2 - annotation: !!omap + - bigg.metabolite: mn2 - chebi: CHEBI:29035 - kegg.compound: C19610 - metanetx.chemical: MNXM2255 @@ -23064,6 +24878,7 @@ - formula: Mn - charge: 2 - annotation: !!omap + - bigg.metabolite: mn2 - chebi: CHEBI:29035 - kegg.compound: C19610 - metanetx.chemical: MNXM2255 @@ -23075,6 +24890,7 @@ - formula: C6H14O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: mnl - chebi: CHEBI:16899 - kegg.compound: C00392 - metanetx.chemical: MNXM615 @@ -23099,15 +24915,16 @@ - annotation: !!omap - chebi: CHEBI:49031 - kegg.compound: C15999 - - metanetx.chemical: MNXM2246 + - metanetx.chemical: MNXM722780 - sbo: SBO:0000247 - !!omap - id: s_3808 - name: tRNA(Pro) - compartment: m - - formula: R - - charge: -1 + - formula: RH + - charge: 0 - annotation: !!omap + - bigg.metabolite: trnapro - chebi: CHEBI:29177 - kegg.compound: C01649 - metanetx.chemical: MNXM90667 @@ -23116,9 +24933,10 @@ - id: s_3809 - name: Pro-tRNA(Pro) - compartment: m - - formula: C5H8NOR - - charge: 0 + - formula: C5H9NOR + - charge: 1 - annotation: !!omap + - bigg.metabolite: protrna - chebi: CHEBI:29154 - kegg.compound: C02702 - metanetx.chemical: MNXM247 @@ -23130,9 +24948,10 @@ - formula: C5H6NO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 5oxpro - chebi: CHEBI:58402 - kegg.compound: C01879 - - metanetx.chemical: MNXM964 + - metanetx.chemical: MNXM722719 - sbo: SBO:0000247 - !!omap - id: s_3811 @@ -23141,6 +24960,7 @@ - formula: C9H15N5O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: hthbp - chebi: CHEBI:15642 - kegg.compound: C15522 - metanetx.chemical: MNXM31340 @@ -23152,8 +24972,10 @@ - formula: C9H13N5O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: CE2705 - chebi: CHEBI:20680 - kegg.compound: C00268 + - metanetx.chemical: MNXM162257 - sbo: SBO:0000247 - !!omap - id: s_3813 @@ -23162,6 +24984,7 @@ - formula: O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: o2s - chebi: CHEBI:18421 - kegg.compound: C00704 - metanetx.chemical: MNXM330 @@ -23173,6 +24996,7 @@ - formula: C6H11O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: 2doxg6p - chebi: CHEBI:84760 - kegg.compound: C06369 - metanetx.chemical: MNXM3809 @@ -23184,6 +25008,7 @@ - formula: C6H12O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: 2dglc - chebi: CHEBI:84755 - kegg.compound: C00586 - metanetx.chemical: MNXM2925 @@ -23213,6 +25038,7 @@ - formula: C15H23N6O5S - charge: 1 - annotation: !!omap + - bigg.metabolite: amet - chebi: CHEBI:67040 - kegg.compound: C00019 - metanetx.chemical: MNXM16 @@ -23225,6 +25051,7 @@ - charge: 1 - annotation: !!omap - chebi: CHEBI:29969 + - metanetx.chemical: MNXM59465 - sbo: SBO:0000247 - !!omap - id: s_3820 @@ -23233,6 +25060,7 @@ - formula: C14H20N6O5S - charge: 0 - annotation: !!omap + - bigg.metabolite: ahcys - chebi: CHEBI:16680 - kegg.compound: C00021 - metanetx.chemical: MNXM19 @@ -23245,6 +25073,7 @@ - charge: 1 - annotation: !!omap - chebi: CHEBI:61929 + - metanetx.chemical: MNXM63025 - sbo: SBO:0000247 - !!omap - id: s_3822 @@ -23253,6 +25082,7 @@ - formula: Zn - charge: 2 - annotation: !!omap + - bigg.metabolite: zn2 - chebi: CHEBI:29105 - kegg.compound: C00038 - metanetx.chemical: MNXM149 @@ -23264,6 +25094,7 @@ - formula: Zn - charge: 2 - annotation: !!omap + - bigg.metabolite: zn2 - chebi: CHEBI:29105 - kegg.compound: C00038 - metanetx.chemical: MNXM149 @@ -23275,6 +25106,7 @@ - formula: Fe - charge: 3 - annotation: !!omap + - bigg.metabolite: ficytb5 - chebi: CHEBI:18097 - kegg.compound: C00996 - metanetx.chemical: MNXM1083 @@ -23286,6 +25118,7 @@ - formula: Fe - charge: 2 - annotation: !!omap + - bigg.metabolite: focytb5 - kegg.compound: C00999 - sbo: SBO:0000247 - !!omap @@ -23295,6 +25128,7 @@ - formula: Fe - charge: 3 - annotation: !!omap + - bigg.metabolite: ficytb5 - chebi: CHEBI:18097 - kegg.compound: C00996 - metanetx.chemical: MNXM1083 @@ -23306,6 +25140,7 @@ - formula: Fe - charge: 2 - annotation: !!omap + - bigg.metabolite: focytb5 - kegg.compound: C00999 - sbo: SBO:0000247 - !!omap @@ -23316,6 +25151,7 @@ - charge: 0 - annotation: !!omap - kegg.compound: C20227 + - metanetx.chemical: MNXM5393 - sbo: SBO:0000247 - !!omap - id: s_3829 @@ -23346,6 +25182,7 @@ - formula: C10H16N3O6S - charge: -1 - annotation: !!omap + - bigg.metabolite: gthrd - chebi: CHEBI:57925 - kegg.compound: C00051 - metanetx.chemical: MNXM57 @@ -23359,6 +25196,7 @@ - annotation: !!omap - chebi: CHEBI:16042 - kegg.compound: C00462 + - metanetx.chemical: MNXM55844 - sbo: SBO:0000247 - !!omap - id: s_3833 @@ -23391,6 +25229,7 @@ - annotation: !!omap - chebi: CHEBI:16042 - kegg.compound: C00462 + - metanetx.chemical: MNXM55844 - sbo: SBO:0000247 - !!omap - id: s_3836 @@ -23410,6 +25249,7 @@ - formula: C5H11NO3S - charge: 0 - annotation: !!omap + - bigg.metabolite: metsox_S__L - chebi: CHEBI:17016 - kegg.compound: C02989 - metanetx.chemical: MNXM2246 @@ -23421,7 +25261,9 @@ - formula: C5H10N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: L_alagly - chebi: CHEBI:73757 + - metanetx.chemical: MNXM15783 - sbo: SBO:0000247 - !!omap - id: s_3839 @@ -23430,6 +25272,7 @@ - formula: C2H5NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: gly - chebi: CHEBI:15428 - kegg.compound: C00037 - metanetx.chemical: MNXM29 @@ -23441,7 +25284,9 @@ - formula: C9H18N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_ile__L - chebi: CHEBI:73770 + - metanetx.chemical: MNXM15786 - sbo: SBO:0000247 - !!omap - id: s_3841 @@ -23472,6 +25317,7 @@ - formula: C10H16N3O6S - charge: -1 - annotation: !!omap + - bigg.metabolite: gthrd - chebi: CHEBI:57925 - kegg.compound: C00051 - metanetx.chemical: MNXM57 @@ -23485,6 +25331,7 @@ - annotation: !!omap - chebi: CHEBI:16042 - kegg.compound: C00462 + - metanetx.chemical: MNXM55844 - sbo: SBO:0000247 - !!omap - id: s_3845 @@ -23504,6 +25351,7 @@ - formula: C6H6O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: dhdascb - chebi: CHEBI:27956 - kegg.compound: C05422 - metanetx.chemical: MNXM250 @@ -23515,9 +25363,10 @@ - formula: C6H8O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: ascb__L - chebi: CHEBI:38290 - kegg.compound: C00072 - - metanetx.chemical: MNXM89592 + - metanetx.chemical: MNXM129 - sbo: SBO:0000247 - !!omap - id: s_3848 @@ -23526,6 +25375,7 @@ - formula: C6H6O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: dhdascb - chebi: CHEBI:27956 - kegg.compound: C05422 - metanetx.chemical: MNXM250 @@ -23537,6 +25387,7 @@ - formula: C20H30N6O12S2 - charge: -2 - annotation: !!omap + - bigg.metabolite: gthox - chebi: CHEBI:58297 - kegg.compound: C00127 - metanetx.chemical: MNXM151 @@ -23548,9 +25399,10 @@ - formula: C6H8O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: ascb__L - chebi: CHEBI:38290 - kegg.compound: C00072 - - metanetx.chemical: MNXM89592 + - metanetx.chemical: MNXM129 - sbo: SBO:0000247 - !!omap - id: s_3851 @@ -23572,7 +25424,7 @@ - annotation: !!omap - chebi: CHEBI:58273 - kegg.compound: C00117 - - metanetx.chemical: MNXM116 + - metanetx.chemical: MNXM722712 - sbo: SBO:0000247 - !!omap - id: s_3853 @@ -23583,6 +25435,7 @@ - annotation: !!omap - chebi: CHEBI:8744 - kegg.compound: C05729 + - metanetx.chemical: MNXM7734 - sbo: SBO:0000247 - !!omap - id: s_3854 @@ -23602,6 +25455,7 @@ - formula: Fe - charge: 3 - annotation: !!omap + - bigg.metabolite: fe3 - chebi: CHEBI:29034 - kegg.compound: C14819 - metanetx.chemical: MNXM196 @@ -23610,15 +25464,16 @@ - id: s_3856 - name: Glycyl-tRNA(Ala) - compartment: c - - charge: 0 + - formula: C2H5NOR + - charge: 1 - annotation: !!omap - sbo: SBO:0000247 - !!omap - id: s_3857 - name: D-tyrosyl-tRNA(Tyr) - compartment: c - - formula: C9H10NO3R - - charge: 0 + - formula: C9H11NO2R + - charge: 1 - annotation: !!omap - sbo: SBO:0000247 - !!omap @@ -23639,6 +25494,7 @@ - formula: C6H4NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: HC01104 - chebi: CHEBI:61146 - kegg.compound: C03360 - metanetx.chemical: MNXM3867 @@ -23650,6 +25506,7 @@ - formula: C6H4NO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 4nph - chebi: CHEBI:57917 - kegg.compound: C00870 - metanetx.chemical: MNXM526 @@ -23661,6 +25518,7 @@ - formula: C6H14O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: C01507 - chebi: CHEBI:18202 - kegg.compound: C01507 - metanetx.chemical: MNXM3633 @@ -23672,6 +25530,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: a_gal__D - chebi: CHEBI:28061 - kegg.compound: C00984 - metanetx.chemical: MNXM390 @@ -23694,6 +25553,7 @@ - formula: C4H7O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3hmp - chebi: CHEBI:11805 - kegg.compound: C01188 - metanetx.chemical: MNXM396 @@ -23727,6 +25587,7 @@ - formula: C8H9NO - charge: 0 - annotation: !!omap + - bigg.metabolite: pad - chebi: CHEBI:16562 - kegg.compound: C02505 - metanetx.chemical: MNXM2073 @@ -23738,6 +25599,7 @@ - formula: C10H10N2O - charge: 0 - annotation: !!omap + - bigg.metabolite: iad - chebi: CHEBI:16031 - kegg.compound: C02693 - metanetx.chemical: MNXM2239 @@ -23750,6 +25612,7 @@ - charge: 0 - annotation: !!omap - kegg.compound: C03620 + - metanetx.chemical: MNXM4671 - sbo: SBO:0000247 - !!omap - id: s_3870 @@ -23769,6 +25632,7 @@ - formula: C3H3O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: acryl - chebi: CHEBI:37080 - kegg.compound: C00511 - metanetx.chemical: MNXM1368 @@ -23780,6 +25644,7 @@ - formula: C3H5NO - charge: 0 - annotation: !!omap + - bigg.metabolite: aa - chebi: CHEBI:28619 - kegg.compound: C01659 - metanetx.chemical: MNXM3208 @@ -23802,6 +25667,7 @@ - formula: C7H5O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: bz - chebi: CHEBI:16150 - kegg.compound: C00180 - metanetx.chemical: MNXM217 @@ -23813,6 +25679,7 @@ - formula: C6H11O7 - charge: -1 - annotation: !!omap + - bigg.metabolite: glcn - chebi: CHEBI:18391 - kegg.compound: C00257 - metanetx.chemical: MNXM341 @@ -23846,6 +25713,7 @@ - formula: C11H16O13PR2 - charge: -1 - annotation: !!omap + - bigg.metabolite: pail_cho - chebi: CHEBI:57880 - kegg.compound: C01194 - metanetx.chemical: MNXM62 @@ -23858,6 +25726,7 @@ - charge: -1 - annotation: !!omap - chebi: CHEBI:57265 + - metanetx.chemical: MNXM92477 - sbo: SBO:0000247 - !!omap - id: s_3880 @@ -23866,6 +25735,7 @@ - formula: Ca - charge: 2 - annotation: !!omap + - bigg.metabolite: ca2 - chebi: CHEBI:29108 - kegg.compound: C00076 - metanetx.chemical: MNXM128 @@ -23877,6 +25747,7 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 - metanetx.chemical: MNXM3 @@ -23888,6 +25759,7 @@ - formula: Ca - charge: 2 - annotation: !!omap + - bigg.metabolite: ca2 - chebi: CHEBI:29108 - kegg.compound: C00076 - metanetx.chemical: MNXM128 @@ -23899,6 +25771,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 - metanetx.chemical: MNXM7 @@ -23940,6 +25813,7 @@ - formula: C108H182N2O77P2R - charge: -2 - annotation: !!omap + - metanetx.chemical: MNXM9308 - sbo: SBO:0000247 - !!omap - id: s_3888 @@ -23949,6 +25823,8 @@ - charge: -3 - annotation: !!omap - chebi: CHEBI:57497 + - kegg.compound: C00621 + - metanetx.chemical: MNXM2370 - sbo: SBO:0000247 - !!omap - id: s_3889 @@ -23966,6 +25842,7 @@ - formula: C16H23N5O16P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: gdpmann - chebi: CHEBI:57527 - kegg.compound: C00096 - metanetx.chemical: MNXM82 @@ -23985,6 +25862,7 @@ - formula: C10H12N5O11P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: gdp - chebi: CHEBI:58189 - kegg.compound: C00035 - metanetx.chemical: MNXM30 @@ -24028,6 +25906,7 @@ - formula: C9H14O12P - charge: -3 - annotation: !!omap + - bigg.metabolite: man6pglyc - chebi: CHEBI:60331 - kegg.compound: C16699 - metanetx.chemical: MNXM3470 @@ -24036,9 +25915,10 @@ - id: s_3898 - name: D-mannose 6-phosphate - compartment: v - - formula: C6H13O9P - - charge: 0 + - formula: C6H11O9P + - charge: -2 - annotation: !!omap + - bigg.metabolite: man6p - chebi: CHEBI:17369 - kegg.compound: C00275 - metanetx.chemical: MNXM427 @@ -24050,6 +25930,7 @@ - formula: C3H5O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: glyc__R - chebi: CHEBI:16659 - kegg.compound: C00258 - metanetx.chemical: MNXM189 @@ -24092,6 +25973,7 @@ - charge: -2 - annotation: !!omap - kegg.compound: C20641 + - metanetx.chemical: MNXM145767 - sbo: SBO:0000247 - !!omap - id: s_3904 @@ -24100,6 +25982,7 @@ - formula: C3H7NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ser__D - chebi: CHEBI:16523 - kegg.compound: C00740 - metanetx.chemical: MNXM694 @@ -24111,6 +25994,7 @@ - formula: C5H9NO4 - charge: 0 - annotation: !!omap + - bigg.metabolite: acser - chebi: CHEBI:17981 - kegg.compound: C00979 - metanetx.chemical: MNXM418 @@ -24122,6 +26006,7 @@ - formula: HS - charge: -1 - annotation: !!omap + - bigg.metabolite: h2s - chebi: CHEBI:29919 - kegg.compound: C00283 - metanetx.chemical: MNXM89582 @@ -24133,6 +26018,7 @@ - formula: C5H7O8PR2 - charge: 0 - annotation: !!omap + - bigg.metabolite: pa_EC - chebi: CHEBI:16337 - kegg.compound: C00416 - metanetx.chemical: MNXM96054 @@ -24141,10 +26027,11 @@ - id: s_3908 - name: CDP-diacylglycerol - compartment: m - - formula: C14H17N3O15P2R2 - - charge: -2 + - formula: C14H19N3O15P2R2 + - charge: 0 - annotation: !!omap - - chebi: CHEBI:58332 + - bigg.metabolite: cdpdag_cho + - chebi: CHEBI:17962 - kegg.compound: C00269 - metanetx.chemical: MNXM201 - sbo: SBO:0000247 @@ -24167,7 +26054,7 @@ - annotation: !!omap - chebi: CHEBI:134399 - kegg.compound: C20784 - - metanetx.chemical: MNXM37826 + - metanetx.chemical: MNXM722955 - sbo: SBO:0000247 - !!omap - id: s_3911 @@ -24187,6 +26074,7 @@ - formula: C102H172N2O72P2R - charge: -2 - annotation: !!omap + - metanetx.chemical: MNXM9258 - sbo: SBO:0000247 - !!omap - id: s_3913 @@ -24195,6 +26083,7 @@ - formula: NO - charge: 0 - annotation: !!omap + - bigg.metabolite: no - chebi: CHEBI:16480 - kegg.compound: C00533 - metanetx.chemical: MNXM228 @@ -24206,6 +26095,7 @@ - formula: NO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: no3 - chebi: CHEBI:17632 - kegg.compound: C00244 - metanetx.chemical: MNXM207 @@ -24217,6 +26107,7 @@ - formula: C8H13O2S2 - charge: -1 - annotation: !!omap + - bigg.metabolite: lipoate - chebi: CHEBI:83088 - kegg.compound: C16241 - metanetx.chemical: MNXM1484 @@ -24228,6 +26119,7 @@ - formula: C18H25N5O8PS2 - charge: -1 - annotation: !!omap + - bigg.metabolite: lipoamp - chebi: CHEBI:83091 - kegg.compound: C16238 - metanetx.chemical: MNXM2392 @@ -24279,6 +26171,7 @@ - formula: C5H10N2O3S - charge: 0 - annotation: !!omap + - bigg.metabolite: cgly - chebi: CHEBI:4047 - kegg.compound: C01419 - metanetx.chemical: MNXM683 @@ -24290,6 +26183,7 @@ - formula: Cl - charge: -1 - annotation: !!omap + - bigg.metabolite: cl - chebi: CHEBI:17996 - kegg.compound: C00698 - metanetx.chemical: MNXM43 @@ -24303,6 +26197,7 @@ - annotation: !!omap - chebi: CHEBI:61557 - kegg.compound: C03802 + - metanetx.chemical: MNXM96380 - sbo: SBO:0000247 - !!omap - id: s_3928 @@ -24312,6 +26207,8 @@ - charge: -2 - annotation: !!omap - chebi: CHEBI:58043 + - kegg.compound: C00171 + - metanetx.chemical: MNXM80910 - sbo: SBO:0000247 - !!omap - id: s_3929 @@ -24342,6 +26239,7 @@ - formula: O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: o2s - chebi: CHEBI:18421 - kegg.compound: C00704 - metanetx.chemical: MNXM330 @@ -24350,9 +26248,10 @@ - id: s_3932 - name: G00012 - compartment: er - - formula: C50H66N4O29 + - formula: C50H82N4O37 - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM9328 - sbo: SBO:0000247 - !!omap - id: s_3933 @@ -24361,6 +26260,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: man - chebi: CHEBI:4208 - kegg.compound: C00159 - metanetx.chemical: MNXM182 @@ -24383,6 +26283,7 @@ - formula: NO2 - charge: -1 - annotation: !!omap + - bigg.metabolite: no2 - chebi: CHEBI:16301 - kegg.compound: C00088 - metanetx.chemical: MNXM107 @@ -24394,7 +26295,9 @@ - formula: Fe - charge: 3 - annotation: !!omap + - bigg.metabolite: fe3 - kegg.compound: C14819 + - metanetx.chemical: MNXM196 - sbo: SBO:0000247 - !!omap - id: s_3937 @@ -24403,6 +26306,7 @@ - formula: C22H31N7O17P3SR - charge: -4 - annotation: !!omap + - bigg.metabolite: acoa - chebi: CHEBI:58342 - kegg.compound: C00040 - metanetx.chemical: MNXM44 @@ -24414,6 +26318,7 @@ - formula: C4H6O7PR - charge: -2 - annotation: !!omap + - bigg.metabolite: 1ag3p_SC - chebi: CHEBI:57970 - kegg.compound: C00681 - metanetx.chemical: MNXM145527 @@ -24425,6 +26330,7 @@ - formula: C5H5O8PR2 - charge: -2 - annotation: !!omap + - bigg.metabolite: pa_EC - chebi: CHEBI:58608 - kegg.compound: C00416 - metanetx.chemical: MNXM96054 @@ -24449,24 +26355,27 @@ - annotation: !!omap - chebi: CHEBI:82696 - kegg.compound: C02872 + - metanetx.chemical: MNXM51194 - sbo: SBO:0000247 - !!omap - id: s_3942 - name: 8-oxo-dGTP - compartment: p - - formula: C10H16N5O14P3 + - formula: C10H12N5O14P3 - charge: -4 - annotation: !!omap - kegg.compound: C19967 + - metanetx.chemical: MNXM4425 - sbo: SBO:0000247 - !!omap - id: s_3943 - name: 8-oxo-dGMP - compartment: p - - formula: C10H14N5O8P + - formula: C10H12N5O8P - charge: -2 - annotation: !!omap - kegg.compound: C19968 + - metanetx.chemical: MNXM2497 - sbo: SBO:0000247 - !!omap - id: s_3944 @@ -24497,6 +26406,7 @@ - formula: C8H13OS3R - charge: 0 - annotation: !!omap + - bigg.metabolite: lipACP - chebi: CHEBI:80400 - kegg.compound: C16239 - metanetx.chemical: MNXM19093 @@ -24519,6 +26429,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: f6p_B - chebi: CHEBI:57634 - kegg.compound: C05345 - metanetx.chemical: MNXM89621 @@ -24530,6 +26441,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: glc__bD - chebi: CHEBI:15903 - kegg.compound: C00221 - metanetx.chemical: MNXM105 @@ -24541,6 +26453,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: g6p_B - chebi: CHEBI:58247 - kegg.compound: C01172 - metanetx.chemical: MNXM508 @@ -24563,6 +26476,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: g6p_A - chebi: CHEBI:58225 - kegg.compound: C00668 - metanetx.chemical: MNXM215 @@ -24571,9 +26485,10 @@ - id: s_3953 - name: D-Glucosamine - compartment: c - - formula: C6H13NO5 - - charge: 0 + - formula: C6H14NO5 + - charge: 1 - annotation: !!omap + - bigg.metabolite: gam - chebi: CHEBI:47977 - kegg.compound: C00329 - metanetx.chemical: MNXM533 @@ -24585,6 +26500,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: fru_B - chebi: CHEBI:28645 - kegg.compound: C02336 - metanetx.chemical: MNXM1542 @@ -24596,6 +26512,7 @@ - formula: C3H5O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: glyc__R - chebi: CHEBI:16659 - kegg.compound: C00258 - metanetx.chemical: MNXM189 @@ -24629,6 +26546,7 @@ - formula: C6H8O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: glcurn - chebi: CHEBI:18268 - kegg.compound: C02670 - metanetx.chemical: MNXM17108 @@ -24640,6 +26558,7 @@ - formula: C6H8O8 - charge: -2 - annotation: !!omap + - bigg.metabolite: glcr - chebi: CHEBI:30612 - kegg.compound: C00818 - metanetx.chemical: MNXM744 @@ -24651,6 +26570,7 @@ - formula: C7H16NO - charge: 1 - annotation: !!omap + - bigg.metabolite: 4tmeabut - chebi: CHEBI:18020 - kegg.compound: C01149 - metanetx.chemical: MNXM940 @@ -24659,9 +26579,10 @@ - id: s_3964 - name: 4-Trimethylammoniobutanoate - compartment: c - - formula: C7H16NO2 - - charge: 1 + - formula: C7H15NO2 + - charge: 0 - annotation: !!omap + - bigg.metabolite: 4tmeabutn - chebi: CHEBI:1941 - kegg.compound: C01181 - metanetx.chemical: MNXM626 @@ -24673,6 +26594,7 @@ - formula: C4H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: mmtsa - chebi: CHEBI:62413 - kegg.compound: C06002 - metanetx.chemical: MNXM933 @@ -24684,6 +26606,7 @@ - formula: C4H4O4 - charge: -2 - annotation: !!omap + - bigg.metabolite: mmal - chebi: CHEBI:17453 - kegg.compound: C02170 - metanetx.chemical: MNXM1572 @@ -24695,6 +26618,7 @@ - formula: C5H6N2O - charge: 0 - annotation: !!omap + - bigg.metabolite: im4act - chebi: CHEBI:27398 - kegg.compound: C05130 - metanetx.chemical: MNXM1745 @@ -24703,9 +26627,10 @@ - id: s_3968 - name: Imidazole-4-acetate - compartment: c - - formula: C5H6N2O2 - - charge: 0 + - formula: C5H5N2O2 + - charge: -1 - annotation: !!omap + - bigg.metabolite: im4ac - chebi: CHEBI:16974 - kegg.compound: C02835 - metanetx.chemical: MNXM1330 @@ -24717,6 +26642,7 @@ - formula: C27H46O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: xol7ah2al - chebi: CHEBI:27428 - kegg.compound: C05445 - metanetx.chemical: MNXM1174 @@ -24728,8 +26654,10 @@ - formula: C27H45O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: dhcholestanate - chebi: CHEBI:16577 - kegg.compound: C04554 + - metanetx.chemical: MNXM484588 - sbo: SBO:0000247 - !!omap - id: s_3971 @@ -24738,6 +26666,7 @@ - formula: C10H9NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: 5hoxindact - chebi: CHEBI:50157 - kegg.compound: C05634 - metanetx.chemical: MNXM1057 @@ -24746,9 +26675,10 @@ - id: s_3972 - name: 5-Hydroxyindoleacetate - compartment: c - - formula: C10H9NO3 - - charge: 0 + - formula: C10H8NO3 + - charge: -1 - annotation: !!omap + - bigg.metabolite: 5hoxindoa - chebi: CHEBI:27823 - kegg.compound: C05635 - metanetx.chemical: MNXM1961 @@ -24760,6 +26690,7 @@ - formula: C6H11NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: n4abutn - chebi: CHEBI:7386 - kegg.compound: C05936 - metanetx.chemical: MNXM1527 @@ -24771,6 +26702,7 @@ - formula: C6H10NO3 - charge: -1 - annotation: !!omap + - bigg.metabolite: 4aabutn - chebi: CHEBI:11951 - kegg.compound: C02946 - metanetx.chemical: MNXM2083 @@ -24834,8 +26766,8 @@ - id: s_3980 - name: Chloroacetic acid - compartment: c - - formula: C2H3ClO2 - - charge: 0 + - formula: C2H2ClO2 + - charge: -1 - annotation: !!omap - chebi: CHEBI:27869 - kegg.compound: C06755 @@ -24848,6 +26780,7 @@ - formula: C10H14O - charge: 0 - annotation: !!omap + - bigg.metabolite: pylald - chebi: CHEBI:15421 - kegg.compound: C02576 - metanetx.chemical: MNXM2149 @@ -24856,9 +26789,10 @@ - id: s_3982 - name: Perillic acid - compartment: c - - formula: C10H14O2 - - charge: 0 + - formula: C10H13O2 + - charge: -1 - annotation: !!omap + - bigg.metabolite: peracd - chebi: CHEBI:36999 - kegg.compound: C11924 - metanetx.chemical: MNXM2414 @@ -24878,8 +26812,8 @@ - id: s_3984 - name: Farnesoic acid - compartment: c - - formula: C15H24O2 - - charge: 0 + - formula: C15H23O2 + - charge: -1 - annotation: !!omap - chebi: CHEBI:84162 - kegg.compound: C16502 @@ -24912,6 +26846,7 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 - metanetx.chemical: MNXM7 @@ -24924,6 +26859,7 @@ - charge: 0 - annotation: !!omap - chebi: CHEBI:75757 + - metanetx.chemical: MNXM62354 - sbo: SBO:0000247 - !!omap - id: s_3989 @@ -24950,6 +26886,7 @@ - formula: C9H14N4O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: carn - chebi: CHEBI:15727 - kegg.compound: C00386 - metanetx.chemical: MNXM1419 @@ -24961,6 +26898,7 @@ - formula: C10H16N4O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ans - chebi: CHEBI:18323 - kegg.compound: C01262 - metanetx.chemical: MNXM2639 @@ -24972,6 +26910,7 @@ - formula: C72H122N2O47P2R - charge: -2 - annotation: !!omap + - metanetx.chemical: MNXM9262 - sbo: SBO:0000247 - !!omap - id: s_3994 @@ -24980,6 +26919,7 @@ - formula: C78H132N2O52P2R - charge: -2 - annotation: !!omap + - metanetx.chemical: MNXM9265 - sbo: SBO:0000247 - !!omap - id: s_3995 @@ -24996,6 +26936,8 @@ - formula: C90H152N2O62P2R - charge: -2 - annotation: !!omap + - kegg.compound: C05868 + - metanetx.chemical: MNXM31425 - sbo: SBO:0000247 - !!omap - id: s_3997 @@ -25004,6 +26946,7 @@ - formula: C2H3O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: glyclt - chebi: CHEBI:29805 - kegg.compound: C00160 - metanetx.chemical: MNXM222 @@ -25015,6 +26958,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: sucr - chebi: CHEBI:17992 - kegg.compound: C00089 - metanetx.chemical: MNXM167 @@ -25026,6 +26970,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: isomal - chebi: CHEBI:28189 - kegg.compound: C00252 - metanetx.chemical: MNXM58018 @@ -25037,6 +26982,7 @@ - formula: C12H20O10 - charge: 0 - annotation: !!omap + - bigg.metabolite: starch - chebi: CHEBI:28675 - kegg.compound: C00721 - sbo: SBO:0000247 @@ -25047,6 +26993,7 @@ - formula: C96H162N2O67P2R - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM9336 - sbo: SBO:0000247 - !!omap - id: s_4002 @@ -25054,6 +27001,7 @@ - compartment: er - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM7903 - sbo: SBO:0000247 - !!omap - id: s_4003 @@ -25061,6 +27009,7 @@ - compartment: er - charge: 0 - annotation: !!omap + - metanetx.chemical: MNXM9266 - sbo: SBO:0000247 - !!omap - id: s_4004 @@ -25079,6 +27028,7 @@ - formula: C10H13N5O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: dad_5 - chebi: CHEBI:17319 - kegg.compound: C05198 - metanetx.chemical: MNXM316 @@ -25111,6 +27061,7 @@ - formula: CHN - charge: 0 - annotation: !!omap + - bigg.metabolite: cyan - chebi: CHEBI:18407 - kegg.compound: C01326 - metanetx.chemical: MNXM254 @@ -25122,6 +27073,7 @@ - formula: HO3S2 - charge: -1 - annotation: !!omap + - bigg.metabolite: tsul - chebi: CHEBI:33541 - kegg.compound: C00320 - metanetx.chemical: MNXM323 @@ -25133,6 +27085,7 @@ - formula: O3S - charge: -2 - annotation: !!omap + - bigg.metabolite: so3 - chebi: CHEBI:17359 - kegg.compound: C11481 - metanetx.chemical: MNXM105630 @@ -25141,9 +27094,10 @@ - id: s_4012 - name: thiocyanate - compartment: m - - formula: CHNS - - charge: 0 + - formula: CNS + - charge: -1 - annotation: !!omap + - bigg.metabolite: tcynt - chebi: CHEBI:29200 - kegg.compound: C01755 - metanetx.chemical: MNXM762 @@ -25155,6 +27109,7 @@ - formula: Mg - charge: 2 - annotation: !!omap + - bigg.metabolite: mg2 - chebi: CHEBI:18420 - kegg.compound: C00305 - metanetx.chemical: MNXM653 @@ -25166,6 +27121,7 @@ - formula: Mg - charge: 2 - annotation: !!omap + - bigg.metabolite: mg2 - chebi: CHEBI:18420 - kegg.compound: C00305 - metanetx.chemical: MNXM653 @@ -25177,9 +27133,10 @@ - formula: C15H22N2O17P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: udpg - chebi: CHEBI:58367 - kegg.compound: C00029 - - metanetx.chemical: MNXM52 + - metanetx.chemical: MNXM722710 - sbo: SBO:0000247 - !!omap - id: s_4016 @@ -25188,6 +27145,7 @@ - formula: O4S - charge: -2 - annotation: !!omap + - bigg.metabolite: so4 - chebi: CHEBI:16189 - kegg.compound: C00059 - metanetx.chemical: MNXM58 @@ -25199,6 +27157,7 @@ - formula: C8H15NO6 - charge: 0 - annotation: !!omap + - bigg.metabolite: acgam - chebi: CHEBI:506227 - kegg.compound: C00140 - metanetx.chemical: MNXM143 @@ -25221,6 +27180,7 @@ - formula: Cu - charge: 2 - annotation: !!omap + - bigg.metabolite: cu2 - chebi: CHEBI:29036 - kegg.compound: C00070 - metanetx.chemical: MNXM632 @@ -25232,6 +27192,7 @@ - formula: Cu - charge: 2 - annotation: !!omap + - bigg.metabolite: cu2 - chebi: CHEBI:29036 - kegg.compound: C00070 - metanetx.chemical: MNXM632 @@ -25243,6 +27204,7 @@ - formula: C5H6NO4 - charge: -1 - annotation: !!omap + - bigg.metabolite: HC00591 - chebi: CHEBI:16769 - kegg.compound: C00940 - metanetx.chemical: MNXM575 @@ -25284,6 +27246,7 @@ - formula: C17H25N3O17P2 - charge: -2 - annotation: !!omap + - bigg.metabolite: uacgam - chebi: CHEBI:57705 - kegg.compound: C00043 - metanetx.chemical: MNXM47 @@ -25295,6 +27258,7 @@ - formula: Zn - charge: 2 - annotation: !!omap + - bigg.metabolite: zn2 - chebi: CHEBI:29105 - kegg.compound: C00038 - metanetx.chemical: MNXM149 @@ -25306,6 +27270,7 @@ - formula: Zn - charge: 2 - annotation: !!omap + - bigg.metabolite: zn2 - chebi: CHEBI:29105 - kegg.compound: C00038 - metanetx.chemical: MNXM149 @@ -25330,6 +27295,7 @@ - annotation: !!omap - chebi: CHEBI:16042 - kegg.compound: C00462 + - metanetx.chemical: MNXM55844 - sbo: SBO:0000247 - !!omap - id: s_4030 @@ -25349,6 +27315,7 @@ - formula: Fe - charge: 3 - annotation: !!omap + - bigg.metabolite: fe3 - chebi: CHEBI:29034 - kegg.compound: C14819 - metanetx.chemical: MNXM196 @@ -25360,6 +27327,7 @@ - formula: C6H13N2O - charge: 1 - annotation: !!omap + - bigg.metabolite: pcollglys - chebi: CHEBI:29969 - kegg.compound: C02188 - sbo: SBO:0000247 @@ -25379,6 +27347,7 @@ - formula: C8H15N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_gln__L - chebi: CHEBI:73788 - metanetx.chemical: MNXM40495 - sbo: SBO:0000247 @@ -25389,6 +27358,7 @@ - formula: C8H15N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_gln__L - chebi: CHEBI:73788 - metanetx.chemical: MNXM40495 - sbo: SBO:0000247 @@ -25399,6 +27369,7 @@ - formula: C8H15N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_gln__L - chebi: CHEBI:73788 - metanetx.chemical: MNXM40495 - sbo: SBO:0000247 @@ -25409,6 +27380,7 @@ - formula: C8H13N2O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: LalaLglu - chebi: CHEBI:61396 - kegg.compound: C20958 - metanetx.chemical: MNXM4026 @@ -25420,6 +27392,7 @@ - formula: C8H13N2O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: LalaLglu - chebi: CHEBI:61396 - kegg.compound: C20958 - metanetx.chemical: MNXM4026 @@ -25431,6 +27404,7 @@ - formula: C8H13N2O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: LalaLglu - chebi: CHEBI:61396 - kegg.compound: C20958 - metanetx.chemical: MNXM4026 @@ -25442,6 +27416,7 @@ - formula: C7H14N2O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_Thr__L - chebi: CHEBI:73762 - metanetx.chemical: MNXM40497 - sbo: SBO:0000247 @@ -25452,6 +27427,7 @@ - formula: C7H14N2O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_Thr__L - chebi: CHEBI:73762 - metanetx.chemical: MNXM40497 - sbo: SBO:0000247 @@ -25462,6 +27438,7 @@ - formula: C7H14N2O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_Thr__L - chebi: CHEBI:73762 - metanetx.chemical: MNXM40497 - sbo: SBO:0000247 @@ -25472,6 +27449,7 @@ - formula: C4H9NO3 - charge: 0 - annotation: !!omap + - bigg.metabolite: thr__L - chebi: CHEBI:16857 - kegg.compound: C00188 - metanetx.chemical: MNXM142 @@ -25523,6 +27501,7 @@ - formula: C3H7O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: glyc1p - chebi: CHEBI:231935 - kegg.compound: C03189 - metanetx.chemical: MNXM682 @@ -25534,6 +27513,7 @@ - formula: C3H7O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: glyc1p - chebi: CHEBI:231935 - kegg.compound: C03189 - metanetx.chemical: MNXM682 @@ -25545,6 +27525,7 @@ - formula: C9H14N4O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_his__L - chebi: CHEBI:73771 - metanetx.chemical: MNXM40496 - sbo: SBO:0000247 @@ -25555,6 +27536,7 @@ - formula: C9H14N4O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_his__L - chebi: CHEBI:73771 - metanetx.chemical: MNXM40496 - sbo: SBO:0000247 @@ -25565,6 +27547,7 @@ - formula: C9H14N4O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_his__L - chebi: CHEBI:73771 - metanetx.chemical: MNXM40496 - sbo: SBO:0000247 @@ -25575,6 +27558,7 @@ - formula: C6H11N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: gly_asn__L - chebi: CHEBI:73888 - metanetx.chemical: MNXM55268 - sbo: SBO:0000247 @@ -25585,6 +27569,7 @@ - formula: C6H11N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: gly_asn__L - chebi: CHEBI:73888 - metanetx.chemical: MNXM55268 - sbo: SBO:0000247 @@ -25595,6 +27580,7 @@ - formula: C6H11N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: gly_asn__L - chebi: CHEBI:73888 - metanetx.chemical: MNXM55268 - sbo: SBO:0000247 @@ -25605,6 +27591,7 @@ - formula: C7H13N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: gly_gln__L - chebi: CHEBI:73898 - metanetx.chemical: MNXM55276 - sbo: SBO:0000247 @@ -25615,6 +27602,7 @@ - formula: C7H13N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: gly_gln__L - chebi: CHEBI:73898 - metanetx.chemical: MNXM55276 - sbo: SBO:0000247 @@ -25625,6 +27613,7 @@ - formula: C7H13N3O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: gly_gln__L - chebi: CHEBI:73898 - metanetx.chemical: MNXM55276 - sbo: SBO:0000247 @@ -25635,6 +27624,7 @@ - formula: C7H11N2O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: gly_glu__L - chebi: CHEBI:73784 - metanetx.chemical: MNXM55454 - sbo: SBO:0000247 @@ -25645,6 +27635,7 @@ - formula: C7H11N2O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: gly_glu__L - chebi: CHEBI:73784 - metanetx.chemical: MNXM55454 - sbo: SBO:0000247 @@ -25655,6 +27646,7 @@ - formula: C7H11N2O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: gly_glu__L - chebi: CHEBI:73784 - metanetx.chemical: MNXM55454 - sbo: SBO:0000247 @@ -25665,6 +27657,7 @@ - formula: C3H7O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: glyc2p - chebi: CHEBI:58083 - kegg.compound: C02979 - metanetx.chemical: MNXM2527 @@ -25676,6 +27669,7 @@ - formula: C3H7O6P - charge: -2 - annotation: !!omap + - bigg.metabolite: glyc2p - chebi: CHEBI:58083 - kegg.compound: C02979 - metanetx.chemical: MNXM2527 @@ -25687,6 +27681,7 @@ - formula: C4H8NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: thrp - chebi: CHEBI:58675 - kegg.compound: C12147 - metanetx.chemical: MNXM1492 @@ -25698,6 +27693,7 @@ - formula: C4H8NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: thrp - chebi: CHEBI:58675 - kegg.compound: C12147 - metanetx.chemical: MNXM1492 @@ -25729,6 +27725,7 @@ - formula: C10H12N5O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: 3gmp - chebi: CHEBI:60732 - kegg.compound: C06193 - metanetx.chemical: MNXM2183 @@ -25740,6 +27737,7 @@ - formula: C10H12N5O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: 3gmp - chebi: CHEBI:60732 - kegg.compound: C06193 - metanetx.chemical: MNXM2183 @@ -25751,6 +27749,7 @@ - formula: C2H2O6P - charge: -3 - annotation: !!omap + - bigg.metabolite: 2pglyc - chebi: CHEBI:58033 - kegg.compound: C00988 - metanetx.chemical: MNXM2074 @@ -25762,6 +27761,7 @@ - formula: C2H2O6P - charge: -3 - annotation: !!omap + - bigg.metabolite: 2pglyc - chebi: CHEBI:58033 - kegg.compound: C00988 - metanetx.chemical: MNXM2074 @@ -25783,6 +27783,7 @@ - formula: C2H8NS - charge: 1 - annotation: !!omap + - bigg.metabolite: cysam - chebi: CHEBI:58029 - kegg.compound: C01678 - metanetx.chemical: MNXM1226 @@ -25794,6 +27795,7 @@ - formula: C2H8NS - charge: 1 - annotation: !!omap + - bigg.metabolite: cysam - chebi: CHEBI:58029 - kegg.compound: C01678 - metanetx.chemical: MNXM1226 @@ -25826,6 +27828,7 @@ - formula: C3H6NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: pser__D - chebi: CHEBI:58680 - kegg.compound: C02532 - metanetx.chemical: MNXM4752 @@ -25837,6 +27840,7 @@ - formula: C3H6NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: pser__D - chebi: CHEBI:58680 - kegg.compound: C02532 - metanetx.chemical: MNXM4752 @@ -25848,6 +27852,7 @@ - formula: C4H9NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: C02356 - chebi: CHEBI:35621 - metanetx.chemical: MNXM15850 - sbo: SBO:0000247 @@ -25858,6 +27863,7 @@ - formula: C4H9NO2 - charge: 0 - annotation: !!omap + - bigg.metabolite: C02356 - chebi: CHEBI:35621 - metanetx.chemical: MNXM15850 - sbo: SBO:0000247 @@ -25890,6 +27896,7 @@ - formula: C9H11N2O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: 3ump - chebi: CHEBI:60784 - kegg.compound: C01368 - metanetx.chemical: MNXM2184 @@ -25901,6 +27908,7 @@ - formula: C9H11N2O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: 3ump - chebi: CHEBI:60784 - kegg.compound: C01368 - metanetx.chemical: MNXM2184 @@ -25912,6 +27920,7 @@ - formula: C7H14N2O3S - charge: 0 - annotation: !!omap + - bigg.metabolite: gly_met__L - chebi: CHEBI:74393 - metanetx.chemical: MNXM55287 - sbo: SBO:0000247 @@ -25922,6 +27931,7 @@ - formula: C7H14N2O3S - charge: 0 - annotation: !!omap + - bigg.metabolite: gly_met__L - chebi: CHEBI:74393 - metanetx.chemical: MNXM55287 - sbo: SBO:0000247 @@ -25932,6 +27942,7 @@ - formula: C7H14N2O3S - charge: 0 - annotation: !!omap + - bigg.metabolite: gly_met__L - chebi: CHEBI:74393 - metanetx.chemical: MNXM55287 - sbo: SBO:0000247 @@ -25952,6 +27963,7 @@ - formula: C4H7N3O - charge: 0 - annotation: !!omap + - bigg.metabolite: creat - chebi: CHEBI:16737 - kegg.compound: C00791 - metanetx.chemical: MNXM1470 @@ -25973,6 +27985,7 @@ - formula: C4H7N3O - charge: 0 - annotation: !!omap + - bigg.metabolite: creat - chebi: CHEBI:16737 - kegg.compound: C00791 - metanetx.chemical: MNXM1470 @@ -25984,6 +27997,7 @@ - formula: C6H14N4O5P - charge: -1 - annotation: !!omap + - bigg.metabolite: argp - chebi: CHEBI:58477 - kegg.compound: C05945 - metanetx.chemical: MNXM3663 @@ -25995,6 +28009,7 @@ - formula: C6H14N4O5P - charge: -1 - annotation: !!omap + - bigg.metabolite: argp - chebi: CHEBI:58477 - kegg.compound: C05945 - metanetx.chemical: MNXM3663 @@ -26006,6 +28021,7 @@ - formula: C10H11N5O7P - charge: -1 - annotation: !!omap + - bigg.metabolite: 23cgmp - chebi: CHEBI:60837 - kegg.compound: C06194 - metanetx.chemical: MNXM3149 @@ -26017,6 +28033,7 @@ - formula: C10H11N5O7P - charge: -1 - annotation: !!omap + - bigg.metabolite: 23cgmp - chebi: CHEBI:60837 - kegg.compound: C06194 - metanetx.chemical: MNXM3149 @@ -26028,6 +28045,7 @@ - formula: C9H10NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: tyrp - chebi: CHEBI:62338 - kegg.compound: C06501 - metanetx.chemical: MNXM3323 @@ -26039,6 +28057,7 @@ - formula: C9H10NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: tyrp - chebi: CHEBI:62338 - kegg.compound: C06501 - metanetx.chemical: MNXM3323 @@ -26050,6 +28069,7 @@ - formula: O10P3 - charge: -5 - annotation: !!omap + - bigg.metabolite: pppi - chebi: CHEBI:18036 - kegg.compound: C00536 - metanetx.chemical: MNXM332 @@ -26061,6 +28081,7 @@ - formula: O10P3 - charge: -5 - annotation: !!omap + - bigg.metabolite: pppi - chebi: CHEBI:18036 - kegg.compound: C00536 - metanetx.chemical: MNXM332 @@ -26094,6 +28115,7 @@ - formula: C9H10N2O8P - charge: -1 - annotation: !!omap + - bigg.metabolite: 23cump - chebi: CHEBI:60873 - kegg.compound: C02355 - metanetx.chemical: MNXM3150 @@ -26105,6 +28127,7 @@ - formula: C9H10N2O8P - charge: -1 - annotation: !!omap + - bigg.metabolite: 23cump - chebi: CHEBI:60873 - kegg.compound: C02355 - metanetx.chemical: MNXM3150 @@ -26116,6 +28139,7 @@ - formula: C3H6NO4S - charge: -1 - annotation: !!omap + - bigg.metabolite: 3sala - chebi: CHEBI:61085 - kegg.compound: C00606 - metanetx.chemical: MNXM498 @@ -26127,6 +28151,7 @@ - formula: C3H6NO4S - charge: -1 - annotation: !!omap + - bigg.metabolite: 3sala - chebi: CHEBI:61085 - kegg.compound: C00606 - metanetx.chemical: MNXM498 @@ -26138,6 +28163,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: 3amp - chebi: CHEBI:60880 - kegg.compound: C01367 - metanetx.chemical: MNXM1985 @@ -26149,6 +28175,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: 3amp - chebi: CHEBI:60880 - kegg.compound: C01367 - metanetx.chemical: MNXM1985 @@ -26160,6 +28187,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: pala - chebi: CHEBI:18394 - kegg.compound: C01742 - metanetx.chemical: MNXM3518 @@ -26171,6 +28199,7 @@ - formula: C12H22O11 - charge: 0 - annotation: !!omap + - bigg.metabolite: pala - chebi: CHEBI:18394 - kegg.compound: C01742 - metanetx.chemical: MNXM3518 @@ -26182,6 +28211,7 @@ - formula: C5H8NO3S - charge: -1 - annotation: !!omap + - bigg.metabolite: CE1310 - chebi: CHEBI:78236 - kegg.compound: C06809 - metanetx.chemical: MNXM98606 @@ -26193,6 +28223,7 @@ - formula: C5H8NO3S - charge: -1 - annotation: !!omap + - bigg.metabolite: CE1310 - chebi: CHEBI:78236 - kegg.compound: C06809 - metanetx.chemical: MNXM98606 @@ -26204,6 +28235,7 @@ - formula: O6S4 - charge: -2 - annotation: !!omap + - bigg.metabolite: tet - chebi: CHEBI:15226 - kegg.compound: C02084 - metanetx.chemical: MNXM1781 @@ -26215,6 +28247,7 @@ - formula: HO3S2 - charge: -1 - annotation: !!omap + - bigg.metabolite: tsul - chebi: CHEBI:33542 - kegg.compound: C00320 - metanetx.chemical: MNXM323 @@ -26226,6 +28259,7 @@ - formula: O6S4 - charge: -2 - annotation: !!omap + - bigg.metabolite: tet - chebi: CHEBI:15226 - kegg.compound: C02084 - metanetx.chemical: MNXM1781 @@ -26237,6 +28271,7 @@ - formula: C2H5O4S - charge: -1 - annotation: !!omap + - bigg.metabolite: isetac - chebi: CHEBI:61904 - kegg.compound: C05123 - metanetx.chemical: MNXM1630 @@ -26248,6 +28283,7 @@ - formula: C2H5O4S - charge: -1 - annotation: !!omap + - bigg.metabolite: isetac - chebi: CHEBI:61904 - kegg.compound: C05123 - metanetx.chemical: MNXM1630 @@ -26259,6 +28295,7 @@ - formula: C6H9O7 - charge: -1 - annotation: !!omap + - bigg.metabolite: 5dglcn - chebi: CHEBI:58143 - kegg.compound: C01062 - metanetx.chemical: MNXM963 @@ -26270,6 +28307,7 @@ - formula: C6H9O7 - charge: -1 - annotation: !!omap + - bigg.metabolite: 5dglcn - chebi: CHEBI:58143 - kegg.compound: C01062 - metanetx.chemical: MNXM963 @@ -26281,6 +28319,7 @@ - formula: C7H11N2O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: ala_L_asp__L - chebi: CHEBI:74363 - metanetx.chemical: MNXM40494 - sbo: SBO:0000247 @@ -26291,6 +28330,7 @@ - formula: C7H11N2O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: ala_L_asp__L - chebi: CHEBI:74363 - metanetx.chemical: MNXM40494 - sbo: SBO:0000247 @@ -26301,6 +28341,7 @@ - formula: C7H11N2O5 - charge: -1 - annotation: !!omap + - bigg.metabolite: ala_L_asp__L - chebi: CHEBI:74363 - metanetx.chemical: MNXM40494 - sbo: SBO:0000247 @@ -26311,8 +28352,9 @@ - formula: C7H14O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: madg - chebi: CHEBI:320061 - - metanetx.chemical: MNXM61741 + - metanetx.chemical: MNXM724960 - sbo: SBO:0000247 - !!omap - id: s_4123 @@ -26321,6 +28363,7 @@ - formula: CH4O - charge: 0 - annotation: !!omap + - bigg.metabolite: meoh - chebi: CHEBI:17790 - kegg.compound: C00132 - metanetx.chemical: MNXM157 @@ -26332,6 +28375,7 @@ - formula: CH4O - charge: 0 - annotation: !!omap + - bigg.metabolite: meoh - chebi: CHEBI:17790 - kegg.compound: C00132 - metanetx.chemical: MNXM157 @@ -26343,8 +28387,9 @@ - formula: C7H14O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: madg - chebi: CHEBI:320061 - - metanetx.chemical: MNXM61741 + - metanetx.chemical: MNXM724960 - sbo: SBO:0000247 - !!omap - id: s_4126 @@ -26353,6 +28398,7 @@ - formula: C9H11N3O7P - charge: -1 - annotation: !!omap + - bigg.metabolite: 23ccmp - chebi: CHEBI:60877 - kegg.compound: C02354 - metanetx.chemical: MNXM3148 @@ -26364,6 +28410,7 @@ - formula: C9H11N3O7P - charge: -1 - annotation: !!omap + - bigg.metabolite: 23ccmp - chebi: CHEBI:60877 - kegg.compound: C02354 - metanetx.chemical: MNXM3148 @@ -26375,6 +28422,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag__D - chebi: CHEBI:4249 - kegg.compound: C00795 - metanetx.chemical: MNXM92401 @@ -26386,6 +28434,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: tag6p__D - chebi: CHEBI:58695 - kegg.compound: C01097 - metanetx.chemical: MNXM795 @@ -26397,6 +28446,7 @@ - formula: C6H12O6 - charge: 0 - annotation: !!omap + - bigg.metabolite: tag__D - chebi: CHEBI:4249 - kegg.compound: C00795 - metanetx.chemical: MNXM92401 @@ -26419,6 +28469,7 @@ - formula: C4H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: acac - chebi: CHEBI:13705 - kegg.compound: C00164 - metanetx.chemical: MNXM154 @@ -26430,6 +28481,7 @@ - formula: C4H5O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: acac - chebi: CHEBI:13705 - kegg.compound: C00164 - metanetx.chemical: MNXM154 @@ -26441,6 +28493,7 @@ - formula: C7H12NO3S - charge: -1 - annotation: !!omap + - bigg.metabolite: C02712 - chebi: CHEBI:132957 - kegg.compound: C02712 - metanetx.chemical: MNXM7576 @@ -26452,6 +28505,7 @@ - formula: C7H12NO3S - charge: -1 - annotation: !!omap + - bigg.metabolite: C02712 - chebi: CHEBI:132957 - kegg.compound: C02712 - metanetx.chemical: MNXM7576 @@ -26485,6 +28539,7 @@ - formula: C3H6NO5S - charge: -1 - annotation: !!omap + - bigg.metabolite: Lcyst - chebi: CHEBI:58090 - kegg.compound: C00506 - metanetx.chemical: MNXM713 @@ -26496,6 +28551,7 @@ - formula: C3H6NO5S - charge: -1 - annotation: !!omap + - bigg.metabolite: Lcyst - chebi: CHEBI:58090 - kegg.compound: C00506 - metanetx.chemical: MNXM713 @@ -26507,6 +28563,7 @@ - formula: C18H32O16 - charge: 0 - annotation: !!omap + - bigg.metabolite: malttr - chebi: CHEBI:61993 - kegg.compound: C01835 - metanetx.chemical: MNXM468 @@ -26518,6 +28575,7 @@ - formula: C3H4O7P - charge: -3 - annotation: !!omap + - bigg.metabolite: 2pg - chebi: CHEBI:58289 - kegg.compound: C00631 - metanetx.chemical: MNXM275 @@ -26529,6 +28587,7 @@ - formula: C3H4O7P - charge: -3 - annotation: !!omap + - bigg.metabolite: 3pg - chebi: CHEBI:58272 - kegg.compound: C00197 - metanetx.chemical: MNXM126 @@ -26540,6 +28599,7 @@ - formula: C8H16N2O3S - charge: 0 - annotation: !!omap + - bigg.metabolite: met_L_ala__L - chebi: CHEBI:73610 - metanetx.chemical: MNXM61647 - sbo: SBO:0000247 @@ -26550,6 +28610,7 @@ - formula: C8H16N2O3S - charge: 0 - annotation: !!omap + - bigg.metabolite: met_L_ala__L - chebi: CHEBI:73610 - metanetx.chemical: MNXM61647 - sbo: SBO:0000247 @@ -26560,6 +28621,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: g1p - chebi: CHEBI:57629 - kegg.compound: C00103 - metanetx.chemical: MNXM89588 @@ -26571,6 +28633,7 @@ - formula: CH2NO5P - charge: -2 - annotation: !!omap + - bigg.metabolite: cbp - chebi: CHEBI:58228 - kegg.compound: C00169 - metanetx.chemical: MNXM138 @@ -26582,6 +28645,7 @@ - formula: C3H6NO6P - charge: -2 - annotation: !!omap + - bigg.metabolite: pser__L - chebi: CHEBI:57524 - kegg.compound: C01005 - metanetx.chemical: MNXM379 @@ -26593,6 +28657,7 @@ - formula: C10H12N5O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: gmp - chebi: CHEBI:58115 - kegg.compound: C00144 - metanetx.chemical: MNXM113 @@ -26604,6 +28669,7 @@ - formula: C6H6O24P6 - charge: -12 - annotation: !!omap + - bigg.metabolite: minohp - chebi: CHEBI:58130 - kegg.compound: C01204 - metanetx.chemical: MNXM491 @@ -26615,6 +28681,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: g6p - chebi: CHEBI:61548 - kegg.compound: C00092 - metanetx.chemical: MNXM160 @@ -26626,6 +28693,7 @@ - formula: C9H11N2O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: ump - chebi: CHEBI:57865 - kegg.compound: C00105 - metanetx.chemical: MNXM80 @@ -26637,6 +28705,7 @@ - formula: C3H2O6P - charge: -3 - annotation: !!omap + - bigg.metabolite: pep - chebi: CHEBI:58702 - kegg.compound: C00074 - metanetx.chemical: MNXM73 @@ -26648,6 +28717,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: man6p - chebi: CHEBI:58735 - kegg.compound: C00275 - metanetx.chemical: MNXM427 @@ -26659,6 +28729,7 @@ - formula: C2H7NO4P - charge: -1 - annotation: !!omap + - bigg.metabolite: ethamp - chebi: CHEBI:58190 - kegg.compound: C00346 - metanetx.chemical: MNXM187 @@ -26670,6 +28741,7 @@ - formula: C6H10O10P - charge: -3 - annotation: !!omap + - bigg.metabolite: 6pgc - chebi: CHEBI:58759 - kegg.compound: C00345 - metanetx.chemical: MNXM325 @@ -26681,6 +28753,7 @@ - formula: C6H11O9P - charge: -2 - annotation: !!omap + - bigg.metabolite: man1p - chebi: CHEBI:58409 - kegg.compound: C00636 - metanetx.chemical: MNXM721 @@ -26692,6 +28765,7 @@ - formula: HO7P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: ppi - chebi: CHEBI:33019 - kegg.compound: C00013 - metanetx.chemical: MNXM11 @@ -26703,6 +28777,7 @@ - formula: C5H13NO4P - charge: -1 - annotation: !!omap + - bigg.metabolite: cholp - chebi: CHEBI:295975 - kegg.compound: C00588 - metanetx.chemical: MNXM229 @@ -26714,6 +28789,7 @@ - formula: HO3S2 - charge: -1 - annotation: !!omap + - bigg.metabolite: tsul - chebi: CHEBI:33542 - kegg.compound: C00320 - metanetx.chemical: MNXM323 @@ -26725,6 +28801,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: amp - chebi: CHEBI:456215 - kegg.compound: C00020 - metanetx.chemical: MNXM14 @@ -26736,6 +28813,7 @@ - formula: C10H11N5O6P - charge: -1 - annotation: !!omap + - bigg.metabolite: 23camp - chebi: CHEBI:60879 - kegg.compound: C02353 - metanetx.chemical: MNXM2598 @@ -26747,6 +28825,7 @@ - formula: C10H12N5O7P - charge: -2 - annotation: !!omap + - bigg.metabolite: amp2p - chebi: CHEBI:77740 - kegg.compound: C00946 - metanetx.chemical: MNXM7028 @@ -26758,6 +28837,7 @@ - formula: C9H12N3O8P - charge: -2 - annotation: !!omap + - bigg.metabolite: cmp - chebi: CHEBI:60377 - kegg.compound: C00055 - metanetx.chemical: MNXM31 @@ -26769,6 +28849,7 @@ - formula: C6H14NO5 - charge: 1 - annotation: !!omap + - bigg.metabolite: gam - chebi: CHEBI:58723 - kegg.compound: C00329 - metanetx.chemical: MNXM533 @@ -26780,6 +28861,7 @@ - formula: C5H10O4 - charge: 0 - annotation: !!omap + - bigg.metabolite: drib - chebi: CHEBI:28816 - kegg.compound: C08347 - metanetx.chemical: MNXM2474 @@ -26791,6 +28873,7 @@ - formula: C6H13N3O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: citr__L - chebi: CHEBI:16349 - kegg.compound: C00327 - metanetx.chemical: MNXM211 @@ -26802,6 +28885,7 @@ - formula: C3H6O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: dha - chebi: CHEBI:16016 - kegg.compound: C00184 - metanetx.chemical: MNXM460 @@ -26813,6 +28897,7 @@ - formula: C9H18N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_ile__L - chebi: CHEBI:73770 - metanetx.chemical: MNXM15786 - sbo: SBO:0000247 @@ -26823,6 +28908,7 @@ - formula: C9H18N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: ala_L_ile__L - chebi: CHEBI:73770 - metanetx.chemical: MNXM15786 - sbo: SBO:0000247 @@ -26833,6 +28919,7 @@ - formula: C5H10N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: L_alagly - chebi: CHEBI:73757 - metanetx.chemical: MNXM15783 - sbo: SBO:0000247 @@ -26843,6 +28930,7 @@ - formula: C5H10N2O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: L_alagly - chebi: CHEBI:73757 - metanetx.chemical: MNXM15783 - sbo: SBO:0000247 @@ -26853,6 +28941,7 @@ - formula: C7H9NO5 - charge: -2 - annotation: !!omap + - bigg.metabolite: acglu - chebi: CHEBI:44337 - kegg.compound: C00624 - metanetx.chemical: MNXM730 @@ -26864,6 +28953,7 @@ - formula: C7H9NO5 - charge: -2 - annotation: !!omap + - bigg.metabolite: acglu - chebi: CHEBI:44337 - kegg.compound: C00624 - metanetx.chemical: MNXM730 @@ -26875,6 +28965,7 @@ - formula: C8H15NOS2 - charge: 0 - annotation: !!omap + - bigg.metabolite: lpam - chebi: CHEBI:17460 - kegg.compound: C00248 - metanetx.chemical: MNXM1024 @@ -26886,6 +28977,7 @@ - formula: C8H15NOS2 - charge: 0 - annotation: !!omap + - bigg.metabolite: lpam - chebi: CHEBI:17460 - kegg.compound: C00248 - metanetx.chemical: MNXM1024 @@ -26897,6 +28989,7 @@ - formula: C5H11NO3S - charge: 0 - annotation: !!omap + - bigg.metabolite: metsox_S__L - chebi: CHEBI:17016 - kegg.compound: C02989 - metanetx.chemical: MNXM2246 @@ -26908,6 +29001,7 @@ - formula: C8H7O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: hgentis - chebi: CHEBI:16169 - kegg.compound: C00544 - metanetx.chemical: MNXM345 @@ -26919,6 +29013,7 @@ - formula: C8H6O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: 4mlacac - chebi: CHEBI:17105 - kegg.compound: C01036 - metanetx.chemical: MNXM691 @@ -26930,6 +29025,7 @@ - formula: C8H6O6 - charge: -2 - annotation: !!omap + - bigg.metabolite: 4fumacac - chebi: CHEBI:18034 - kegg.compound: C01061 - metanetx.chemical: MNXM708 @@ -26941,8 +29037,9 @@ - formula: C5H10O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: xylu__L - chebi: CHEBI:17140 - - kegg.compound: C00310 + - kegg.compound: C00312 - metanetx.chemical: MNXM597 - sbo: SBO:0000247 - !!omap @@ -26952,6 +29049,7 @@ - formula: C5H12O5 - charge: 0 - annotation: !!omap + - bigg.metabolite: abt__D - chebi: CHEBI:18333 - kegg.compound: C01904 - metanetx.chemical: MNXM1018 @@ -26963,6 +29061,7 @@ - formula: C5H6O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: 2hog - chebi: CHEBI:11596 - kegg.compound: C02630 - metanetx.chemical: MNXM1210 @@ -26974,6 +29073,7 @@ - formula: C24H36N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: ppcoa - chebi: CHEBI:57392 - kegg.compound: C00100 - metanetx.chemical: MNXM86 @@ -26985,6 +29085,7 @@ - formula: C3H3O3 - charge: -1 - annotation: !!omap + - bigg.metabolite: msa - chebi: CHEBI:33190 - kegg.compound: C00222 - metanetx.chemical: MNXM244 @@ -26996,6 +29097,7 @@ - formula: C5H9O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 23dhmb - chebi: CHEBI:49072 - kegg.compound: C04272 - metanetx.chemical: MNXM114097 @@ -27007,6 +29109,7 @@ - formula: C5H7O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: 3hmoa - chebi: CHEBI:11812 - kegg.compound: C04181 - metanetx.chemical: MNXM1638 @@ -27029,6 +29132,7 @@ - formula: C5H7O4 - charge: -1 - annotation: !!omap + - bigg.metabolite: alac__S - chebi: CHEBI:58476 - kegg.compound: C06010 - metanetx.chemical: MNXM114079 @@ -27040,6 +29144,7 @@ - formula: C5H6O5 - charge: -2 - annotation: !!omap + - bigg.metabolite: r3mmal - chebi: CHEBI:58511 - kegg.compound: C06032 - metanetx.chemical: MNXM2512 @@ -27051,6 +29156,7 @@ - formula: C39H62N7O17P3S - charge: -4 - annotation: !!omap + - bigg.metabolite: lnlccoa - chebi: CHEBI:57383 - kegg.compound: C02050 - metanetx.chemical: MNXM638 @@ -27062,6 +29168,7 @@ - formula: C18H31O2 - charge: -1 - annotation: !!omap + - bigg.metabolite: lnlc - chebi: CHEBI:30245 - kegg.compound: C01595 - metanetx.chemical: MNXM293 @@ -27073,6 +29180,7 @@ - formula: C24H42O21 - charge: 0 - annotation: !!omap + - bigg.metabolite: stys - chebi: CHEBI:17164 - kegg.compound: C01613 - metanetx.chemical: MNXM1503 @@ -27084,6 +29192,7 @@ - formula: C18H32O16 - charge: 0 - annotation: !!omap + - bigg.metabolite: raffin - chebi: CHEBI:16634 - kegg.compound: C00492 - metanetx.chemical: MNXM621 @@ -27095,6 +29204,7 @@ - formula: C8H8O3 - charge: 0 - annotation: !!omap + - bigg.metabolite: 4hphac - chebi: CHEBI:18101 - kegg.compound: C00642 - metanetx.chemical: MNXM3863 @@ -27106,6 +29216,7 @@ - formula: C6H6O2 - charge: 0 - annotation: !!omap + - bigg.metabolite: hqn - chebi: CHEBI:17594 - kegg.compound: C00530 - metanetx.chemical: MNXM376 @@ -27117,8 +29228,10 @@ - formula: C10H12N5O13P3 - charge: -4 - annotation: !!omap + - bigg.metabolite: atp - chebi: CHEBI:30616 - kegg.compound: C00002 + - metanetx.chemical: MNXM3 - sbo: SBO:0000247 - !!omap - id: s_4197 @@ -27127,8 +29240,10 @@ - formula: Ca - charge: 2 - annotation: !!omap + - bigg.metabolite: ca2 - chebi: CHEBI:29108 - kegg.compound: C00076 + - metanetx.chemical: MNXM128 - sbo: SBO:0000247 - !!omap - id: s_4198 @@ -27137,8 +29252,10 @@ - formula: C10H12N5O10P2 - charge: -3 - annotation: !!omap + - bigg.metabolite: adp - chebi: CHEBI:456216 - kegg.compound: C00008 + - metanetx.chemical: MNXM7 - sbo: SBO:0000247 - !!omap - id: s_4199 @@ -27147,8 +29264,10 @@ - formula: Ca - charge: 2 - annotation: !!omap + - bigg.metabolite: ca2 - chebi: CHEBI:29108 - kegg.compound: C00076 + - metanetx.chemical: MNXM128 - sbo: SBO:0000247 - !!omap - id: s_4200 @@ -27157,8 +29276,10 @@ - formula: Cl - charge: -1 - annotation: !!omap + - bigg.metabolite: cl - chebi: CHEBI:17996 - kegg.compound: C00698 + - metanetx.chemical: MNXM43 - sbo: SBO:0000247 - !!omap - id: s_4201 @@ -27167,8 +29288,10 @@ - formula: Cu - charge: 2 - annotation: !!omap + - bigg.metabolite: cu2 - chebi: CHEBI:29036 - kegg.compound: C00070 + - metanetx.chemical: MNXM632 - sbo: SBO:0000247 - !!omap - id: s_4202 @@ -27177,8 +29300,10 @@ - formula: Mn - charge: 2 - annotation: !!omap + - bigg.metabolite: mn2 - chebi: CHEBI:29035 - 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metanetx.reaction: MNXR95260 - pmid: 8972574 @@ -27513,6 +29674,7 @@ - 2.6.1.39 - 2.6.1.57 - 2.6.1.7 + - bigg.reaction: AATA - kegg.reaction: R01939 - metanetx.reaction: MNXR95160 - pmid: @@ -27537,6 +29699,7 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 1.1.1.169 + - bigg.reaction: DPR - kegg.reaction: R02472 - metanetx.reaction: MNXR97779 - sbo: SBO:0000176 @@ -27560,6 +29723,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 2.5.1.54 + - bigg.reaction: DDPAm - kegg.reaction: R01826 - metanetx.reaction: MNXR97218 - sbo: SBO:0000176 @@ -27586,6 +29750,7 @@ - 2.1.1.201 - 2.1.1.64 - 2.7.-.- + - bigg.reaction: 2HPMBQMTm - kegg.reaction: R04983 - metanetx.reaction: MNXR109269 - pmid: 15792955 @@ -27612,6 +29777,7 @@ - 2.1.1.201 - 2.1.1.64 - 2.7.-.- + - bigg.reaction: 2HP6MPMOm - kegg.reaction: R04982 - metanetx.reaction: MNXR109268 - pmid: 15792955 @@ -27634,6 +29800,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - 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ec-code: 2.6.1.42 + - bigg.reaction: OMCDC - kegg.reaction: R01652 - metanetx.reaction: MNXR102180 - sbo: SBO:0000176 @@ -27806,6 +29977,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 2.6.1.42 + - bigg.reaction: OMCDCm - kegg.reaction: R01652 - metanetx.reaction: MNXR102180 - sbo: SBO:0000176 @@ -27826,6 +29998,7 @@ - sce01130 Biosynthesis of antibiotics - annotation: !!omap - ec-code: 3.1.3.7 + - bigg.reaction: BPNT - kegg.reaction: R00188 - metanetx.reaction: MNXR96321 - pmid: 7809627 @@ -27847,6 +30020,7 @@ - ec-code: - 3.1.4.17 - 3.1.4.53 + - bigg.reaction: PDE1 - kegg.reaction: R00191 - metanetx.reaction: MNXR95886 - sbo: SBO:0000176 @@ -27865,6 +30039,7 @@ - subsystem: sce00230 Purine metabolism - annotation: !!omap - ec-code: 3.1.4.53 + - bigg.reaction: PDE2 - metanetx.reaction: MNXR136084 - sbo: SBO:0000176 - confidence_score: 2 @@ -27882,6 +30057,7 @@ - subsystem: sce00230 Purine metabolism - annotation: !!omap - ec-code: 3.1.4.53 + - bigg.reaction: PDE3 - metanetx.reaction: MNXR136083 - sbo: SBO:0000176 - confidence_score: 2 @@ -27899,6 +30075,7 @@ - subsystem: sce00230 Purine metabolism - annotation: !!omap - ec-code: 3.1.4.53 + - bigg.reaction: PDE4 - kegg.reaction: R01234 - metanetx.reaction: MNXR100078 - sbo: SBO:0000176 @@ -27917,6 +30094,7 @@ - subsystem: sce00230 Purine metabolism - annotation: !!omap - ec-code: 3.1.4.53 + - bigg.reaction: PDE5 - metanetx.reaction: MNXR136082 - sbo: SBO:0000176 - confidence_score: 2 @@ -27936,6 +30114,7 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 4.1.99.12 + - bigg.reaction: DB4PS - kegg.reaction: R07281 - metanetx.reaction: MNXR97178 - pmid: 12595523 @@ -27963,6 +30142,7 @@ - 2.7.1.71 - 4.2.1.10 - 4.2.3.4 + - bigg.reaction: DHQTi - kegg.reaction: R03084 - metanetx.reaction: MNXR97449 - sbo: SBO:0000176 @@ -27989,6 +30169,7 @@ - 2.7.1.71 - 4.2.1.10 - 4.2.3.4 + - bigg.reaction: DHQS - kegg.reaction: R03083 - metanetx.reaction: MNXR97447 - pmid: 6355828 @@ -27999,7 +30180,7 @@ - name: 3-dehydrosphinganine reductase - metabolites: !!omap - s_0231: -1 - - s_0795: -2 + - s_0795: -1 - s_1208: 1 - s_1213: -1 - s_1445: 1 @@ -28035,6 +30216,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 2.5.1.54 + - bigg.reaction: DDPA - kegg.reaction: R01826 - metanetx.reaction: MNXR97218 - pmid: 2880280 @@ -28051,6 +30233,7 @@ - upper_bound: 1000 - gene_reaction_rule: YPL252C or YDR376W - annotation: !!omap + - bigg.reaction: 3OPHB5Hm - kegg.reaction: R06865 - metanetx.reaction: MNXR110601 - pmid: 15792955 @@ -28079,6 +30262,7 @@ - metabolites: !!omap - s_0222: -1 - s_0224: 1 + - s_0794: 1 - s_0803: -1 - s_0955: 1 - lower_bound: 0 @@ -28087,6 +30271,7 @@ - subsystem: sce00380 Tryptophan metabolism - annotation: !!omap - ec-code: 3.7.1.3 + - bigg.reaction: HKYNH - kegg.reaction: R02668 - metanetx.reaction: MNXR100656 - sbo: SBO:0000176 @@ -28107,6 +30292,7 @@ - ec-code: - 1.1.1.n12 - 4.2.1.119 + - bigg.reaction: HACD6p - kegg.reaction: R04739 - metanetx.reaction: MNXR100547 - sbo: SBO:0000176 @@ -28117,7 +30303,6 @@ - metabolites: !!omap - s_0147: 1 - s_0224: -1 - - s_0794: 1 - s_1275: -1 - lower_bound: 0 - upper_bound: 1000 @@ -28125,6 +30310,8 @@ - subsystem: sce00380 Tryptophan metabolism - annotation: !!omap - ec-code: 1.13.11.6 + - bigg.reaction: 3HAO + - kegg.reaction: R02665 - metanetx.reaction: MNXR94889 - pmid: 9539135 - sbo: SBO:0000176 @@ -28162,6 +30349,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 4.2.1.33 + - bigg.reaction: IPPMIa - kegg.reaction: R04001 - metanetx.reaction: MNXR100827 - pmid: 3071717 @@ -28187,6 +30375,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 1.1.1.85 + - bigg.reaction: IPMD - kegg.reaction: R04426 - metanetx.reaction: MNXR100878 - pmid: 6297759 @@ -28214,6 +30403,7 @@ - 4.1.1.1 - 4.1.1.43 - 4.1.1.74 + - bigg.reaction: 3MOBDC - metanetx.reaction: MNXR94922 - pmid: 12902239 - sbo: SBO:0000176 @@ -28235,6 +30425,7 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 2.1.2.11 + - bigg.reaction: MTMOHT - kegg.reaction: R01226 - metanetx.reaction: MNXR101702 - sbo: SBO:0000176 @@ -28261,6 +30452,7 @@ - 4.1.1.1 - 4.1.1.43 - 4.1.1.74 + - bigg.reaction: 3MOPDC - kegg.reaction: R03894 - metanetx.reaction: MNXR94925 - pmid: 12902239 @@ -28289,6 +30481,7 @@ - 2.7.1.71 - 4.2.1.10 - 4.2.3.4 + - bigg.reaction: PSCVT - kegg.reaction: R03460 - metanetx.reaction: MNXR103226 - pmid: 6355828 @@ -28308,6 +30501,7 @@ - subsystem: sce00790 Folate biosynthesis - annotation: !!omap - ec-code: 2.6.1.85 + - bigg.reaction: ADCS - kegg.reaction: R01716 - metanetx.reaction: MNXR95440 - sbo: SBO:0000176 @@ -28325,6 +30519,7 @@ - gene_reaction_rule: YMR289W - annotation: !!omap - ec-code: 4.1.3.38 + - bigg.reaction: ADCL - kegg.reaction: R05553 - metanetx.reaction: MNXR95436 - sbo: SBO:0000176 @@ -28348,6 +30543,7 @@ - sce00650 Butanoate metabolism - annotation: !!omap - ec-code: 2.6.1.19 + - bigg.reaction: ABTA - kegg.reaction: R01648 - metanetx.reaction: MNXR95186 - pmid: 10590462 @@ -28371,6 +30567,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 4.2.3.1 + - bigg.reaction: 4HTHRS - kegg.reaction: R05086 - metanetx.reaction: MNXR95024 - pmid: 8082795 @@ -28388,6 +30585,7 @@ - lower_bound: 0 - upper_bound: 1000 - annotation: !!omap + - bigg.reaction: 4HBZFm - kegg.reaction: R01301 - metanetx.reaction: MNXR95011 - pmid: 11583838 @@ -28411,7 +30609,8 @@ - sce01130 Biosynthesis of antibiotics - annotation: !!omap - ec-code: 4.1.1.- - - metanetx.reaction: MNXR95033 + - bigg.reaction: 4MOPDC + - metanetx.reaction: MNXR137950 - pmid: 12902239 - sbo: SBO:0000176 - confidence_score: 3 @@ -28420,7 +30619,7 @@ - name: 4PP-IP5 depyrophosphorylation to IP6 - metabolites: !!omap - s_0279: -1 - - s_0794: 2 + - s_0794: 1 - s_0803: -1 - s_1158: 1 - s_1322: 1 @@ -28446,8 +30645,7 @@ - s_0279: -1 - s_0394: 1 - s_0434: -1 - - s_0794: -2 - - s_0803: 1 + - s_0794: -1 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR017C @@ -28473,6 +30671,7 @@ - subsystem: sce00270 Cysteine and methionine metabolism - annotation: !!omap - ec-code: 2.4.2.28 + - bigg.reaction: MTAP - kegg.reaction: R01402 - metanetx.reaction: MNXR101745 - pmid: 14506228 @@ -28492,6 +30691,7 @@ - subsystem: sce00760 Nicotinate and nicotinamide metabolism - annotation: !!omap - ec-code: 3.1.3.- + - bigg.reaction: NTD4 - kegg.reaction: R00511 - metanetx.reaction: MNXR102034 - pmid: @@ -28515,6 +30715,7 @@ - sce00760 Nicotinate and nicotinamide metabolism - annotation: !!omap - ec-code: 3.1.3.99 + - bigg.reaction: NTD11 - kegg.reaction: R01126 - metanetx.reaction: MNXR102030 - pmid: 12735798 @@ -28534,6 +30735,7 @@ - subsystem: sce00760 Nicotinate and nicotinamide metabolism - annotation: !!omap - ec-code: 3.1.3.- + - bigg.reaction: NTD2 - kegg.reaction: R00963 - metanetx.reaction: MNXR102032 - pmid: @@ -28563,6 +30765,7 @@ - sce01130 Biosynthesis of antibiotics - annotation: !!omap - ec-code: 6.3.5.3 + - bigg.reaction: PRFGS - kegg.reaction: R04463 - metanetx.reaction: MNXR108904 - sbo: SBO:0000176 @@ -28573,7 +30776,7 @@ - metabolites: !!omap - s_0306: -1 - s_0322: 1 - - s_0794: -2 + - s_0794: -1 - s_1207: 1 - s_1212: -1 - lower_bound: 0 @@ -28584,6 +30787,7 @@ - sce01200 Carbon metabolism - annotation: !!omap - ec-code: 1.5.1.20 + - bigg.reaction: MTHFR3 - kegg.reaction: R01224 - metanetx.reaction: MNXR101752 - pmid: 21623372 @@ -28608,6 +30812,7 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 2.3.1.37 + - bigg.reaction: ALASm - kegg.reaction: R00830 - metanetx.reaction: MNXR95695 - sbo: SBO:0000176 @@ -28617,7 +30822,7 @@ - name: 5-diphosphoinositol-1,2,3,4,6-pentakisphosphate diphosphohydrolase - metabolites: !!omap - s_0318: -1 - - s_0794: 2 + - s_0794: 1 - s_0803: -1 - s_1158: 1 - s_1322: 1 @@ -28640,7 +30845,6 @@ - s_0318: 1 - s_0394: 1 - s_0434: -1 - - s_0794: -1 - s_1158: -1 - lower_bound: 0 - upper_bound: 1000 @@ -28670,6 +30874,7 @@ - subsystem: sce00670 One carbon pool by folate - annotation: !!omap - ec-code: 6.3.3.2 + - 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pmid: 8647869 - sbo: SBO:0000176 - confidence_score: 3 @@ -36631,6 +39155,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 4.2.1.36 + - bigg.reaction: HACNHm - kegg.reaction: R04371 - metanetx.reaction: MNXR100552 - pmid: 2507177 @@ -36658,7 +39183,7 @@ - annotation: !!omap - ec-code: 2.3.3.14 - kegg.reaction: R00271 - - metanetx.reaction: MNXR106445 + - metanetx.reaction: MNXR141692 - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -36678,6 +39203,7 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 2.1.1.10 + - bigg.reaction: HCYSMT - kegg.reaction: R00650 - metanetx.reaction: MNXR100577 - pmid: 11013242 @@ -36689,7 +39215,6 @@ - metabolites: !!omap - s_0177: 1 - s_0460: 1 - - s_0799: 1 - s_0836: -1 - s_1200: -1 - s_1205: 1 @@ -36703,6 +39228,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 1.1.1.87 + - kegg.reaction: R01934 - metanetx.reaction: MNXR107239 - pmid: 10714900 - sbo: SBO:0000176 @@ -36728,6 +39254,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 1.1.1.3 + - bigg.reaction: HSDxi - kegg.reaction: R01775 - metanetx.reaction: MNXR100734 - pmid: @@ -36756,6 +39283,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 1.1.1.3 + - bigg.reaction: HSDy - kegg.reaction: R01775 - metanetx.reaction: MNXR100734 - pmid: 8500624 @@ -36779,6 +39307,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 2.7.1.39 + - bigg.reaction: HSK - kegg.reaction: R01771 - metanetx.reaction: MNXR100737 - pmid: 8973190 @@ -36800,6 +39329,7 @@ - sce01130 Biosynthesis of antibiotics - annotation: !!omap - ec-code: 2.3.1.31 + - bigg.reaction: HSERTA - kegg.reaction: R01776 - metanetx.reaction: MNXR100736 - pmid: 16232856 @@ -36809,6 +39339,7 @@ - id: r_0550 - name: hydrogen peroxide reductase (thioredoxin) - metabolites: !!omap + - s_0794: -1 - s_0803: 2 - s_0837: -1 - s_1616: -1 @@ -36818,6 +39349,8 @@ - gene_reaction_rule: (YDR453C and YGR209C) or (YDR453C and YLR043C) - annotation: !!omap - ec-code: 1.11.1.15 + - bigg.reaction: THIORDXi + - metanetx.reaction: MNXR104815 - pmid: 15210711 - sbo: SBO:0000176 - confidence_score: 3 @@ -36825,6 +39358,7 @@ - id: r_0551 - name: hydrogen peroxide reductase (thioredoxin) - metabolites: !!omap + - s_0799: -1 - s_0807: 2 - s_0838: -1 - s_1617: -1 @@ -36834,6 +39368,8 @@ - gene_reaction_rule: YBL064C and YCR083W - annotation: !!omap - ec-code: 1.11.1.15 + - bigg.reaction: THIORDXm + - metanetx.reaction: MNXR104815 - pmid: 10821871 - sbo: SBO:0000176 - confidence_score: 3 @@ -36841,6 +39377,7 @@ - id: r_0552 - name: hydrogen peroxide reductase (thioredoxin) - metabolites: !!omap + - s_0801: -1 - s_0809: 2 - s_0840: -1 - s_1619: -1 @@ -36851,6 +39388,8 @@ - subsystem: sce04122 Sulfur relay system - annotation: !!omap - ec-code: 1.11.1.15 + - bigg.reaction: THIORDXp + - metanetx.reaction: MNXR104815 - pmid: 14640681 - sbo: SBO:0000176 - confidence_score: 3 @@ -36869,6 +39408,7 @@ - subsystem: sce00620 Pyruvate metabolism - annotation: !!omap - ec-code: 3.1.2.6 + - bigg.reaction: GLYOX - kegg.reaction: R01736 - metanetx.reaction: MNXR100353 - sbo: SBO:0000176 @@ -36888,6 +39428,7 @@ - subsystem: sce00620 Pyruvate metabolism - annotation: !!omap - ec-code: 3.1.2.6 + - bigg.reaction: GLYOXm - kegg.reaction: R01736 - metanetx.reaction: MNXR100353 - sbo: SBO:0000176 @@ -36908,6 +39449,7 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 2.5.1.39 + - bigg.reaction: HBZOPT6m - kegg.reaction: R05616 - metanetx.reaction: MNXR100569 - sbo: SBO:0000176 @@ -36929,6 +39471,7 @@ - ec-code: - 2.5.1.3 - 2.7.1.50 + - bigg.reaction: HETZK - kegg.reaction: R04448 - metanetx.reaction: MNXR100611 - sbo: SBO:0000176 @@ -36949,6 +39492,8 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 2.5.1.61 + - bigg.reaction: HMBS + - kegg.reaction: R00084 - metanetx.reaction: MNXR100658 - sbo: SBO:0000176 - confidence_score: 2 @@ -36971,6 +39516,7 @@ - sce01130 Biosynthesis of antibiotics - annotation: !!omap - ec-code: 1.1.1.34 + - bigg.reaction: HMGCOAR - kegg.reaction: R02082 - metanetx.reaction: MNXR107304 - sbo: SBO:0000176 @@ -36997,6 +39543,7 @@ - sce01130 Biosynthesis of antibiotics - annotation: !!omap - ec-code: 2.3.3.10 + - bigg.reaction: HMGCOAS - kegg.reaction: R01978 - metanetx.reaction: MNXR107257 - sbo: SBO:0000176 @@ -37023,6 +39570,7 @@ - sce01130 Biosynthesis of antibiotics - annotation: !!omap - ec-code: 2.3.3.10 + - bigg.reaction: HMGCOASm - kegg.reaction: R01978 - metanetx.reaction: MNXR107257 - sbo: SBO:0000176 @@ -37044,6 +39592,7 @@ - ec-code: - 2.7.1.49 - 2.7.4.7 + - bigg.reaction: HMPK1 - kegg.reaction: R03471 - metanetx.reaction: MNXR100664 - sbo: SBO:0000176 @@ -37064,6 +39613,7 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 2.4.2.8 + - bigg.reaction: HXPRT - kegg.reaction: R01132 - metanetx.reaction: MNXR100752 - sbo: SBO:0000176 @@ -37089,6 +39639,7 @@ - ec-code: - 2.4.2.- - 4.1.3.- + - bigg.reaction: IG3PS - kegg.reaction: R04558 - metanetx.reaction: MNXR100811 - sbo: SBO:0000176 @@ -37109,6 +39660,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 4.2.1.19 + - bigg.reaction: IGPDH - kegg.reaction: R03457 - metanetx.reaction: MNXR100813 - sbo: SBO:0000176 @@ -37131,6 +39683,7 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 1.1.1.205 + - bigg.reaction: IMPD - kegg.reaction: R01130 - metanetx.reaction: MNXR100830 - pmid: 11003640 @@ -37157,6 +39710,7 @@ - ec-code: - 4.1.1.48 - 4.1.3.27 + - bigg.reaction: IGPS - kegg.reaction: R03508 - metanetx.reaction: MNXR100814 - pmid: 6323449 @@ -37184,6 +39738,7 @@ - 4.1.1.1 - 4.1.1.43 - 4.1.1.74 + - bigg.reaction: INDPYRD - kegg.reaction: R01974 - metanetx.reaction: MNXR100837 - pmid: 12902239 @@ -37203,6 +39758,8 @@ - subsystem: sce00190 Oxidative phosphorylation - annotation: !!omap - ec-code: 3.6.1.1 + - bigg.reaction: PPA + - kegg.reaction: R00004 - metanetx.reaction: MNXR100808 - pmid: 8224193 - sbo: SBO:0000176 @@ -37221,6 +39778,8 @@ - subsystem: sce00190 Oxidative phosphorylation - annotation: !!omap - ec-code: 3.6.1.1 + - bigg.reaction: PPAm + - kegg.reaction: R00004 - metanetx.reaction: MNXR100808 - pmid: 1648084 - sbo: SBO:0000176 @@ -37244,6 +39803,7 @@ - ec-code: - 2.1.2.3 - 3.5.4.10 + - bigg.reaction: IMPC - kegg.reaction: R01127 - metanetx.reaction: MNXR100783 - sbo: SBO:0000176 @@ -37254,7 +39814,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: -1 + - s_0800: 1 - s_1157: -1 - s_1159: 1 - lower_bound: 0 @@ -37277,7 +39837,7 @@ - s_0123: -1 - s_0398: 1 - s_0438: -1 - - s_0800: -1 + - s_0800: 1 - s_1157: 1 - lower_bound: 0 - upper_bound: 1000 @@ -37288,6 +39848,7 @@ - sce04138 Autophagy - yeast - annotation: !!omap - ec-code: 2.7.1.151 + - kegg.reaction: R10953 - metanetx.reaction: MNXR114260 - pmid: 11956213 - sbo: SBO:0000176 @@ -37299,7 +39860,7 @@ - s_0124: -1 - s_0398: 1 - s_0438: -1 - - s_0800: -1 + - s_0800: 1 - s_1157: 1 - lower_bound: 0 - upper_bound: 1000 @@ -37323,7 +39884,7 @@ - s_0125: -1 - s_0398: 1 - s_0438: -1 - - s_0800: -1 + - s_0800: 1 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR173C @@ -37346,7 +39907,7 @@ - s_0125: -1 - s_0398: 1 - s_0438: -1 - - s_0800: -1 + - s_0800: 1 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR173C @@ -37747,6 +40308,7 @@ - metabolites: !!omap - s_0129: 1 - s_0477: 1 + - s_0799: 2 - s_0807: -1 - s_0896: -1 - lower_bound: 0 @@ -37766,6 +40328,7 @@ - metabolites: !!omap - s_0129: 1 - s_0480: 1 + - s_0799: 2 - s_0807: -1 - s_0899: -1 - lower_bound: 0 @@ -37785,6 +40348,7 @@ - metabolites: !!omap - s_0129: 1 - s_0489: 1 + - s_0799: 2 - s_0807: -1 - s_0908: -1 - lower_bound: 0 @@ -37804,6 +40368,7 @@ - metabolites: !!omap - s_0129: 1 - s_0492: 1 + - s_0799: 2 - s_0807: -1 - s_0911: -1 - lower_bound: 0 @@ -37823,6 +40388,7 @@ - metabolites: !!omap - s_0129: 1 - s_0483: 1 + - s_0799: 2 - s_0807: -1 - s_0902: -1 - lower_bound: 0 @@ -37842,6 +40408,7 @@ - metabolites: !!omap - s_0129: 1 - s_0486: 1 + - s_0799: 2 - s_0807: -1 - s_0905: -1 - lower_bound: 0 @@ -37861,6 +40428,7 @@ - metabolites: !!omap - s_0129: 1 - s_0495: 1 + - s_0799: 2 - s_0807: -1 - s_0914: -1 - lower_bound: 0 @@ -37880,6 +40448,7 @@ - metabolites: !!omap - s_0129: 1 - s_0498: 1 + - s_0799: 2 - s_0807: -1 - s_0917: -1 - lower_bound: 0 @@ -37899,6 +40468,7 @@ - metabolites: !!omap - s_0129: 1 - s_0501: 1 + - s_0799: 2 - s_0807: -1 - s_0920: -1 - lower_bound: 0 @@ -37918,6 +40488,7 @@ - metabolites: !!omap - s_0129: 1 - s_0504: 1 + - s_0799: 2 - s_0807: -1 - s_0923: -1 - lower_bound: 0 @@ -38317,6 +40888,7 @@ - metabolites: !!omap - s_0127: 1 - s_0475: 1 + - s_0795: 2 - s_0804: -1 - s_0894: -1 - lower_bound: 0 @@ -38336,6 +40908,7 @@ - metabolites: !!omap - s_0127: 1 - s_0478: 1 + - s_0795: 2 - s_0804: -1 - s_0897: -1 - lower_bound: 0 @@ -38355,6 +40928,7 @@ - metabolites: !!omap - s_0127: 1 - s_0487: 1 + - s_0795: 2 - s_0804: -1 - s_0906: -1 - lower_bound: 0 @@ -38374,6 +40948,7 @@ - metabolites: !!omap - s_0127: 1 - s_0490: 1 + - 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s_0534: 1 - - s_0801: 1 + - s_0801: 5 - s_0809: -1 - s_2882: 1 - s_2884: -1 @@ -56076,7 +59599,7 @@ - name: peroxisomal acyl-CoA thioesterase (6:0) - metabolites: !!omap - s_0534: 1 - - s_0801: 1 + - s_0801: 5 - s_0809: -1 - s_2883: 1 - s_2885: -1 @@ -56089,6 +59612,7 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 3.1.2.2 + - bigg.reaction: HXCOAx - metanetx.reaction: MNXR127520 - pmid: 16490786 - sbo: SBO:0000176 @@ -56133,6 +59657,7 @@ - sce01110 Biosynthesis of secondary metabolites - annotation: !!omap - ec-code: 3.1.2.2 + - kegg.reaction: R08176 - metanetx.reaction: MNXR111750 - pmid: 16490786 - sbo: SBO:0000176 @@ -56156,6 +59681,8 @@ - sce04146 Peroxisome - annotation: !!omap - ec-code: 1.3.3.6 + - bigg.reaction: HMR_3102 + - metanetx.reaction: MNXR127857 - pmid: 12697341 - sbo: SBO:0000176 - confidence_score: 3 @@ -56178,6 +59705,8 @@ - sce04146 Peroxisome - annotation: !!omap - ec-code: 1.3.3.6 + - bigg.reaction: HMR_3098 + - metanetx.reaction: MNXR127546 - 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4.2.1.119 + - bigg.reaction: ECOAH7p + - kegg.reaction: R04738 - metanetx.reaction: MNXR97892 - pmid: 12697341 - sbo: SBO:0000176 @@ -56487,6 +60027,8 @@ - ec-code: - 1.1.1.n12 - 4.2.1.119 + - bigg.reaction: HMR_3075 + - kegg.reaction: R07760 - metanetx.reaction: MNXR103466 - pmid: 12697341 - sbo: SBO:0000176 @@ -56512,6 +60054,7 @@ - id: r_2254 - name: 2-enoyl-CoA hydratase (3-hydroxybutanoyl-CoA) - metabolites: !!omap + - s_0801: 4 - s_0809: -1 - s_2886: -1 - s_2902: 1 @@ -56546,6 +60089,7 @@ - id: r_2256 - name: 2-enoyl-CoA hydratase (3-hydroxyoctanoyl-CoA) - metabolites: !!omap + - s_0801: -4 - s_0809: -1 - s_2888: -1 - s_2904: 1 @@ -56556,6 +60100,7 @@ - ec-code: - 1.1.1.n12 - 4.2.1.119 + - metanetx.reaction: MNXR118594 - pmid: 12697341 - sbo: SBO:0000176 - confidence_score: 3 @@ -56607,6 +60152,7 @@ - ec-code: - 1.1.1.n12 - 4.2.1.119 + - metanetx.reaction: MNXR118009 - pmid: 12697341 - sbo: SBO:0000176 - confidence_score: 3 @@ -56665,6 +60211,7 @@ - id: r_2263 - name: 2-enoyl-CoA hydratase (3-hydroxy-cis-octadec-9-enoyl-CoA) - metabolites: !!omap + - s_0801: -4 - s_0809: -1 - s_2897: -1 - s_2911: 1 @@ -56728,6 +60275,8 @@ - ec-code: - 1.1.1.n12 - 4.2.1.119 + - bigg.reaction: HACD4p + - kegg.reaction: R04743 - metanetx.reaction: MNXR100545 - pmid: 12697341 - sbo: SBO:0000176 @@ -56748,6 +60297,8 @@ - ec-code: - 1.1.1.n12 - 4.2.1.119 + - bigg.reaction: HACD5p + - kegg.reaction: R04741 - metanetx.reaction: MNXR100546 - pmid: 12697341 - sbo: SBO:0000176 @@ -56768,6 +60319,8 @@ - ec-code: - 1.1.1.n12 - 4.2.1.119 + - bigg.reaction: HACD7p + - kegg.reaction: R04737 - metanetx.reaction: MNXR100548 - pmid: 12697341 - sbo: SBO:0000176 @@ -56788,6 +60341,7 @@ - ec-code: - 1.1.1.n12 - 4.2.1.119 + - bigg.reaction: HMR_3076 - metanetx.reaction: MNXR126787 - pmid: 12697341 - sbo: SBO:0000176 @@ -57059,6 +60613,8 @@ - sce04146 Peroxisome - annotation: !!omap - ec-code: 2.3.1.16 + - bigg.reaction: ACACT1x + - kegg.reaction: R00238 - metanetx.reaction: MNXR95194 - pmid: 12697341 - sbo: SBO:0000176 @@ -57084,6 +60640,7 @@ - sce04146 Peroxisome - annotation: !!omap - ec-code: 2.3.1.16 + - bigg.reaction: ACACT2 - pmid: 12697341 - sbo: SBO:0000176 - confidence_score: 3 @@ -57108,6 +60665,7 @@ - sce04146 Peroxisome - annotation: !!omap - ec-code: 2.3.1.16 + - bigg.reaction: ACACT3 - pmid: 12697341 - sbo: SBO:0000176 - confidence_score: 3 @@ -57132,6 +60690,7 @@ - sce04146 Peroxisome - annotation: !!omap - ec-code: 2.3.1.16 + - bigg.reaction: HMR_3073 - pmid: 12697341 - sbo: SBO:0000176 - confidence_score: 3 @@ -57156,6 +60715,7 @@ - sce04146 Peroxisome - annotation: !!omap - ec-code: 2.3.1.16 + - bigg.reaction: HMR_3069 - pmid: 12697341 - sbo: SBO:0000176 - confidence_score: 3 @@ -57180,6 +60740,7 @@ - sce04146 Peroxisome - annotation: !!omap - ec-code: 2.3.1.16 + - bigg.reaction: HMR_3065 - pmid: 12697341 - sbo: SBO:0000176 - confidence_score: 3 @@ -57331,6 +60892,7 @@ - id: r_2295 - name: delta3,delta2-enoyl-CoA isomerase (cis-dec-3-enoyl-CoA) - metabolites: !!omap + - s_0801: 4 - s_1507: 1 - s_2926: -1 - lower_bound: 0 @@ -57365,6 +60927,7 @@ - id: r_2297 - name: delta3,delta2-enoyl-CoA isomerase (trans-dodec-3-enoyl-CoA) - metabolites: !!omap + - s_0801: 4 - s_1510: 1 - s_2929: -1 - lower_bound: 0 @@ -57375,6 +60938,7 @@ - sce04146 Peroxisome - annotation: !!omap - ec-code: 5.3.3.8 + - bigg.reaction: FAOXC121x - pmid: 12697341 - sbo: SBO:0000176 - confidence_score: 3 @@ -57382,6 +60946,7 @@ - id: r_2298 - name: delta3,delta2-enoyl-CoA isomerase (cis-dodec-3-enoyl-CoA) - metabolites: !!omap + - s_0801: 4 - s_1510: 1 - s_2927: -1 - lower_bound: 0 @@ -57416,6 +60981,7 @@ - id: r_2300 - name: delta3,delta2-enoyl-CoA isomerase (trans-tetradec-3-enoyl-CoA) - metabolites: !!omap + - s_0801: 4 - s_1519: 1 - s_2931: -1 - lower_bound: 0 @@ -57513,6 +61079,8 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 4.2.1.3 + - bigg.reaction: ACONTb + - kegg.reaction: R01900 - metanetx.reaction: MNXR95387 - pmid: 15975908 - sbo: SBO:0000176 @@ -57521,6 +61089,7 @@ - id: r_2308 - name: glycerol-3-phosphate acyltransferase (16:0), ER membrane - metabolites: !!omap + - s_2783: -2 - s_2785: 1 - s_2789: -1 - s_2934: -1 @@ -57543,6 +61112,7 @@ - id: r_2309 - name: glycerol-3-phosphate acyltransferase (16:1), ER membrane - metabolites: !!omap + - s_2783: -2 - s_2785: 1 - s_2819: -1 - s_2934: -1 @@ -57565,6 +61135,7 @@ - id: r_2310 - name: glycerol-3-phosphate acyltransferase (18:0), ER membrane - metabolites: !!omap + - s_2783: -2 - s_2785: 1 - s_2791: -1 - s_2934: -1 @@ -57587,6 +61158,7 @@ - id: r_2311 - name: glycerol-3-phosphate acyltransferase (18:1), ER membrane - metabolites: !!omap + - s_2783: -2 - s_2785: 1 - s_2821: -1 - s_2934: -1 @@ -57609,6 +61181,7 @@ - id: r_2312 - name: dihydroxyacetone phosphate acyltransferase (16:0), ER membrane - metabolites: !!omap + - s_2783: -2 - s_2785: 1 - s_2789: -1 - s_2939: -1 @@ -57631,6 +61204,7 @@ - id: r_2313 - name: dihydroxyacetone phosphate acyltransferase (16:1), ER membrane - metabolites: !!omap + - s_2783: -2 - s_2785: 1 - s_2819: -1 - s_2939: -1 @@ -57653,6 +61227,7 @@ - id: r_2314 - name: dihydroxyacetone phosphate acyltransferase (18:0), ER membrane - metabolites: !!omap + - s_2783: -2 - s_2785: 1 - s_2791: -1 - s_2939: -1 @@ -57675,6 +61250,7 @@ - id: r_2315 - name: dihydroxyacetone phosphate acyltransferase (18:1), ER membrane - metabolites: !!omap + - s_2783: -2 - s_2785: 1 - s_2821: -1 - s_2939: -1 @@ -57699,6 +61275,7 @@ - metabolites: !!omap - s_0531: 1 - s_0769: -1 + - s_2783: -2 - s_2847: -1 - s_2944: 1 - lower_bound: 0 @@ -57721,6 +61298,7 @@ - metabolites: !!omap - s_0531: 1 - s_0769: -1 + - s_2783: -2 - s_2849: -1 - s_2945: 1 - lower_bound: 0 @@ -57743,6 +61321,7 @@ - metabolites: !!omap - s_0531: 1 - s_0769: -1 + - s_2783: -2 - s_2851: -1 - s_2946: 1 - lower_bound: 0 @@ -57765,6 +61344,7 @@ - metabolites: !!omap - s_0531: 1 - s_0769: -1 + - s_2783: -2 - s_2853: -1 - s_2947: 1 - lower_bound: 0 @@ -57787,6 +61367,7 @@ - metabolites: !!omap - s_0531: 1 - s_0631: -1 + - s_0798: -2 - s_2847: -1 - s_2948: 1 - lower_bound: 0 @@ -57809,6 +61390,7 @@ - metabolites: !!omap - s_0531: 1 - s_0631: -1 + - s_0798: -2 - s_2849: -1 - s_2949: 1 - lower_bound: 0 @@ -57831,6 +61413,7 @@ - metabolites: !!omap - s_0531: 1 - s_0631: -1 + - s_0798: -2 - s_2851: -1 - s_2950: 1 - lower_bound: 0 @@ -57853,6 +61436,7 @@ - metabolites: !!omap - s_0531: 1 - s_0631: -1 + - s_0798: -2 - s_2853: -1 - s_2951: 1 - lower_bound: 0 @@ -58285,6 +61869,7 @@ - id: r_2344 - name: PA phosphatase (1-16:0, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2954: -1 - s_2966: 1 @@ -58305,6 +61890,7 @@ - id: r_2345 - name: PA phosphatase (1-16:0, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2955: -1 - s_2966: 1 @@ -58325,6 +61911,7 @@ - id: r_2346 - name: PA phosphatase (1-16:1, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2956: -1 - s_2966: 1 @@ -58345,6 +61932,7 @@ - id: r_2347 - name: PA phosphatase (1-16:1, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2957: -1 - s_2966: 1 @@ -58365,6 +61953,7 @@ - id: r_2348 - name: PA phosphatase (1-18:0, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2958: -1 - s_2966: 1 @@ -58385,6 +61974,7 @@ - id: r_2349 - name: PA phosphatase (1-18:0, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2959: -1 - s_2966: 1 @@ -58405,6 +61995,7 @@ - id: r_2350 - name: PA phosphatase (1-18:1, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2960: -1 - s_2966: 1 @@ -58425,6 +62016,7 @@ - id: r_2351 - name: PA phosphatase (1-18:1, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2961: -1 - s_2966: 1 @@ -58449,6 +62041,7 @@ - s_2976: -1 - s_2977: 1 - s_2978: 1 + - s_3164: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR284C @@ -58471,6 +62064,7 @@ - s_2977: 1 - s_2979: -1 - s_2980: 1 + - s_3164: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR284C @@ -58493,6 +62087,7 @@ - s_2977: 1 - s_2981: -1 - s_2982: 1 + - s_3164: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR284C @@ -58515,6 +62110,7 @@ - s_2977: 1 - s_2983: -1 - s_2984: 1 + - s_3164: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR284C @@ -58537,6 +62133,7 @@ - s_2977: 1 - s_2985: -1 - s_2986: 1 + - s_3164: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR284C @@ -58559,6 +62156,7 @@ - s_2977: 1 - s_2987: -1 - s_2988: 1 + - s_3164: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR284C @@ -58581,6 +62179,7 @@ - s_2977: 1 - s_2989: -1 - s_2990: 1 + - s_3164: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR284C @@ -58603,6 +62202,7 @@ - s_2977: 1 - s_2991: -1 - s_2992: 1 + - s_3164: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR284C @@ -58625,6 +62225,7 @@ - s_2994: -1 - s_2995: 1 - s_2996: 1 + - s_3146: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR503C @@ -58643,6 +62244,7 @@ - s_2995: 1 - s_2997: -1 - s_2998: 1 + - s_3146: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR503C @@ -58661,6 +62263,7 @@ - s_2995: 1 - s_2999: -1 - s_3000: 1 + - s_3146: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR503C @@ -58679,6 +62282,7 @@ - s_2995: 1 - s_3001: -1 - s_3002: 1 + - s_3146: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR503C @@ -58697,6 +62301,7 @@ - s_2995: 1 - s_3003: -1 - s_3004: 1 + - s_3146: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR503C @@ -58715,6 +62320,7 @@ - s_2995: 1 - s_3005: -1 - s_3006: 1 + - s_3146: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR503C @@ -58733,6 +62339,7 @@ - s_2995: 1 - s_3007: -1 - s_3008: 1 + - s_3146: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR503C @@ -58751,6 +62358,7 @@ - s_2995: 1 - s_3009: -1 - s_3010: 1 + - s_3146: 2 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: YDR503C @@ -60371,7 +63979,7 @@ - id: r_2446 - name: PS synthase (1-16:0, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3084: -1 - s_3107: -1 - s_3108: 1 @@ -60392,7 +64000,7 @@ - id: r_2447 - name: PS synthase (1-16:1, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3085: -1 - s_3107: -1 - s_3108: 1 @@ -60413,7 +64021,7 @@ - id: r_2448 - name: PS synthase (1-18:0, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3086: -1 - s_3107: -1 - s_3108: 1 @@ -60434,7 +64042,7 @@ - id: r_2449 - name: PS synthase (1-18:1, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3087: -1 - s_3107: -1 - s_3108: 1 @@ -60455,7 +64063,7 @@ - id: r_2450 - name: PS synthase (1-16:0, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3088: -1 - s_3107: -1 - s_3108: 1 @@ -60476,7 +64084,7 @@ - id: r_2451 - name: PS synthase (1-16:1, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3089: -1 - s_3107: -1 - s_3108: 1 @@ -60497,7 +64105,7 @@ - id: r_2452 - name: PS synthase (1-18:0, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3090: -1 - s_3107: -1 - s_3108: 1 @@ -60518,7 +64126,7 @@ - id: r_2453 - name: PS synthase (1-18:1, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3091: -1 - s_3107: -1 - s_3108: 1 @@ -60539,7 +64147,7 @@ - id: r_2454 - name: PI synthase (1-16:0, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3084: -1 - s_3108: 1 - s_3117: -1 @@ -60560,7 +64168,7 @@ - id: r_2455 - name: PI synthase (1-16:1, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3085: -1 - s_3108: 1 - s_3117: -1 @@ -60581,7 +64189,7 @@ - id: r_2456 - name: PI synthase (1-18:0, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3086: -1 - s_3108: 1 - s_3117: -1 @@ -60602,7 +64210,7 @@ - id: r_2457 - name: PI synthase (1-18:1, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3087: -1 - s_3108: 1 - s_3117: -1 @@ -60623,7 +64231,7 @@ - id: r_2458 - name: PI synthase (1-16:0, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3088: -1 - s_3108: 1 - s_3117: -1 @@ -60644,7 +64252,7 @@ - id: r_2459 - name: PI synthase (1-16:1, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3089: -1 - s_3108: 1 - s_3117: -1 @@ -60665,7 +64273,7 @@ - id: r_2460 - name: PI synthase (1-18:0, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3090: -1 - s_3108: 1 - s_3117: -1 @@ -60686,7 +64294,7 @@ - id: r_2461 - name: PI synthase (1-18:1, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: 2 - s_3091: -1 - s_3108: 1 - s_3117: -1 @@ -60739,7 +64347,6 @@ - id: r_2464 - name: PS decarboxylase (1-16:0, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: -1 - s_3128: -1 - s_3129: 1 - s_3130: 1 @@ -60758,7 +64365,6 @@ - id: r_2465 - name: PS decarboxylase (1-16:1, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: -1 - s_3129: 1 - s_3131: -1 - s_3132: 1 @@ -60777,7 +64383,6 @@ - id: r_2466 - name: PS decarboxylase (1-18:0, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: -1 - s_3129: 1 - s_3133: -1 - s_3134: 1 @@ -60796,7 +64401,6 @@ - id: r_2467 - name: PS decarboxylase (1-18:1, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: -1 - s_3129: 1 - s_3135: -1 - s_3136: 1 @@ -60815,7 +64419,6 @@ - id: r_2468 - name: PS decarboxylase (1-16:0, 2-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: -1 - s_3129: 1 - s_3137: -1 - s_3138: 1 @@ -60834,7 +64437,6 @@ - id: r_2469 - name: PS decarboxylase (1-16:1, 2-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: -1 - s_3129: 1 - s_3139: -1 - s_3140: 1 @@ -60853,7 +64455,6 @@ - id: r_2470 - name: PS decarboxylase (1-18:0, 2-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: -1 - s_3129: 1 - s_3141: -1 - s_3142: 1 @@ -60872,7 +64473,6 @@ - id: r_2471 - name: PS decarboxylase (1-18:1, 2-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: -1 - s_3129: 1 - s_3143: -1 - s_3144: 1 @@ -60892,7 +64492,6 @@ - name: PS decarboxylase (1-16:0, 2-16:1), Golgi membrane - metabolites: !!omap - s_3145: -1 - - s_3146: -1 - s_3147: 1 - s_3148: 1 - lower_bound: 0 @@ -60910,7 +64509,6 @@ - id: r_2473 - name: PS decarboxylase (1-16:1, 2-16:1), Golgi membrane - metabolites: !!omap - - s_3146: -1 - s_3147: 1 - s_3149: -1 - s_3150: 1 @@ -60929,7 +64527,6 @@ - id: r_2474 - name: PS decarboxylase (1-18:0, 2-16:1), Golgi membrane - metabolites: !!omap - - s_3146: -1 - s_3147: 1 - s_3151: -1 - s_3152: 1 @@ -60948,7 +64545,6 @@ - id: r_2475 - name: PS decarboxylase (1-18:1, 2-16:1), Golgi membrane - metabolites: !!omap - - s_3146: -1 - s_3147: 1 - s_3153: -1 - s_3154: 1 @@ -60967,7 +64563,6 @@ - id: r_2476 - name: PS decarboxylase (1-16:0, 2-18:1), Golgi membrane - metabolites: !!omap - - s_3146: -1 - s_3147: 1 - s_3155: -1 - s_3156: 1 @@ -60986,7 +64581,6 @@ - id: r_2477 - name: PS decarboxylase (1-16:1, 2-18:1), Golgi membrane - metabolites: !!omap - - s_3146: -1 - s_3147: 1 - s_3157: -1 - s_3158: 1 @@ -61005,7 +64599,6 @@ - id: r_2478 - name: PS decarboxylase (1-18:0, 2-18:1), Golgi membrane - metabolites: !!omap - - s_3146: -1 - s_3147: 1 - s_3159: -1 - s_3160: 1 @@ -61024,7 +64617,6 @@ - id: r_2479 - name: PS decarboxylase (1-18:1, 2-18:1), Golgi membrane - metabolites: !!omap - - s_3146: -1 - s_3147: 1 - s_3161: -1 - s_3162: 1 @@ -61044,7 +64636,6 @@ - name: PS decarboxylase (1-16:0, 2-16:1), vacuolar membrane - metabolites: !!omap - s_3163: -1 - - s_3164: -1 - s_3165: 1 - s_3166: 1 - lower_bound: 0 @@ -61062,7 +64653,6 @@ - id: r_2481 - name: PS decarboxylase (1-16:1, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: -1 - s_3165: 1 - s_3167: -1 - s_3168: 1 @@ -61081,7 +64671,6 @@ - id: r_2482 - name: PS decarboxylase (1-18:0, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: -1 - s_3165: 1 - s_3169: -1 - s_3170: 1 @@ -61100,7 +64689,6 @@ - id: r_2483 - name: PS decarboxylase (1-18:1, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: -1 - s_3165: 1 - s_3171: -1 - s_3172: 1 @@ -61119,7 +64707,6 @@ - id: r_2484 - name: PS decarboxylase (1-16:0, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: -1 - s_3165: 1 - s_3173: -1 - s_3174: 1 @@ -61138,7 +64725,6 @@ - id: r_2485 - name: PS decarboxylase (1-16:1, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: -1 - s_3165: 1 - s_3175: -1 - s_3176: 1 @@ -61157,7 +64743,6 @@ - id: r_2486 - name: PS decarboxylase (1-18:0, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: -1 - s_3165: 1 - s_3177: -1 - s_3178: 1 @@ -61176,7 +64761,6 @@ - id: r_2487 - name: PS decarboxylase (1-18:1, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: -1 - s_3165: 1 - s_3179: -1 - s_3180: 1 @@ -61723,7 +65307,7 @@ - id: r_2512 - name: DAG kinase (1-16:0, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: -1 - s_2954: 1 - s_2967: -1 - s_3083: -1 @@ -61743,7 +65327,7 @@ - id: r_2513 - name: DAG kinase (1-16:1, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: -1 - s_2956: 1 - s_2969: -1 - s_3083: -1 @@ -61763,7 +65347,7 @@ - id: r_2514 - name: DAG kinase (1-18:0, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: -1 - s_2958: 1 - s_2971: -1 - s_3083: -1 @@ -61783,7 +65367,7 @@ - id: r_2515 - name: DAG kinase (1-18:1, 2-16:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: -1 - s_2960: 1 - s_2973: -1 - s_3083: -1 @@ -61803,7 +65387,7 @@ - id: r_2516 - name: DAG kinase (1-16:0, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: -1 - s_2955: 1 - s_2968: -1 - s_3083: -1 @@ -61823,7 +65407,7 @@ - id: r_2517 - name: DAG kinase (1-16:1, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: -1 - s_2957: 1 - s_2970: -1 - s_3083: -1 @@ -61843,7 +65427,7 @@ - id: r_2518 - name: DAG kinase (1-18:0, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: -1 - s_2959: 1 - s_2972: -1 - s_3083: -1 @@ -61863,7 +65447,7 @@ - id: r_2519 - name: DAG kinase (1-18:1, 2-18:1), ER membrane - metabolites: !!omap - - s_2783: 1 + - s_2783: -1 - s_2961: 1 - s_2974: -1 - s_3083: -1 @@ -62251,7 +65835,6 @@ - id: r_2536 - name: phosphatidylglycerolphosphate synthase (1-16:0, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 - s_3096: -1 - s_3218: -1 - s_3219: 1 @@ -62269,7 +65852,6 @@ - id: r_2537 - name: phosphatidylglycerolphosphate synthase (1-16:1, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 - s_3098: -1 - s_3218: -1 - s_3219: 1 @@ -62287,7 +65869,6 @@ - id: r_2538 - name: phosphatidylglycerolphosphate synthase (1-18:0, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 - s_3100: -1 - s_3218: -1 - s_3219: 1 @@ -62305,7 +65886,6 @@ - id: r_2539 - name: phosphatidylglycerolphosphate synthase (1-18:1, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 - s_3102: -1 - s_3218: -1 - s_3219: 1 @@ -62323,7 +65903,6 @@ - id: r_2540 - name: phosphatidylglycerolphosphate synthase (1-16:0, 2-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 - s_3104: -1 - s_3218: -1 - s_3219: 1 @@ -62341,7 +65920,6 @@ - id: r_2541 - name: phosphatidylglycerolphosphate synthase (1-16:1, 2-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 - s_3106: -1 - s_3218: -1 - s_3219: 1 @@ -62359,6 +65937,7 @@ - id: r_2542 - name: PGP phosphatase (1-16:0, 2-16:1), mitochondrial membrane - metabolites: !!omap + - s_3094: 2 - s_3220: -1 - s_3226: -1 - s_3227: 1 @@ -62376,6 +65955,7 @@ - id: r_2543 - name: PGP phosphatase (1-16:1, 2-16:1), mitochondrial membrane - metabolites: !!omap + - s_3094: 2 - s_3221: -1 - s_3226: -1 - s_3228: 1 @@ -62393,6 +65973,7 @@ - id: r_2544 - name: PGP phosphatase (1-18:0, 2-16:1), mitochondrial membrane - metabolites: !!omap + - s_3094: 2 - s_3222: -1 - s_3226: -1 - s_3228: 1 @@ -62410,6 +65991,7 @@ - id: r_2545 - name: PGP phosphatase (1-18:1, 2-16:1), mitochondrial membrane - metabolites: !!omap + - s_3094: 2 - s_3223: -1 - s_3226: -1 - s_3228: 1 @@ -62427,6 +66009,7 @@ - id: r_2546 - name: PGP phosphatase (1-16:0, 2-18:1), mitochondrial membrane - metabolites: !!omap + - s_3094: 2 - s_3224: -1 - s_3226: -1 - s_3228: 1 @@ -62444,6 +66027,7 @@ - id: r_2547 - name: PGP phosphatase (1-16:1, 2-18:1), mitochondrial membrane - metabolites: !!omap + - s_3094: 2 - s_3225: -1 - s_3226: -1 - s_3228: 1 @@ -62461,7 +66045,7 @@ - id: r_2548 - name: CL synthase (1-16:0, 2-16:1, 3-16:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3096: -1 - s_3219: 1 - s_3227: -1 @@ -62479,7 +66063,7 @@ - id: r_2549 - name: CL synthase (1-16:0, 2-16:1, 3-16:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3096: -1 - s_3219: 1 - s_3229: -1 @@ -62497,7 +66081,7 @@ - id: r_2550 - name: CL synthase (1-16:0, 2-16:1, 3-18:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3096: -1 - s_3219: 1 - s_3230: -1 @@ -62515,7 +66099,7 @@ - id: r_2551 - name: CL synthase (1-16:0, 2-16:1, 3-18:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3096: -1 - s_3219: 1 - s_3231: -1 @@ -62533,7 +66117,7 @@ - id: r_2552 - name: CL synthase (1-16:0, 2-16:1, 3-16:0, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3096: -1 - s_3219: 1 - s_3232: -1 @@ -62551,7 +66135,7 @@ - id: r_2553 - name: CL synthase (1-16:0, 2-16:1, 3-16:1, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3096: -1 - s_3219: 1 - s_3233: -1 @@ -62569,7 +66153,7 @@ - id: r_2554 - name: CL synthase (1-16:1, 2-16:1, 3-16:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3098: -1 - s_3219: 1 - s_3227: -1 @@ -62587,7 +66171,7 @@ - id: r_2555 - name: CL synthase (1-16:1, 2-16:1, 3-16:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3098: -1 - s_3219: 1 - s_3229: -1 @@ -62605,7 +66189,7 @@ - id: r_2556 - name: CL synthase (1-16:1, 2-16:1, 3-18:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3098: -1 - s_3219: 1 - s_3230: -1 @@ -62623,7 +66207,7 @@ - id: r_2557 - name: CL synthase (1-16:1, 2-16:1, 3-18:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3098: -1 - s_3219: 1 - s_3231: -1 @@ -62641,7 +66225,7 @@ - id: r_2558 - name: CL synthase (1-16:1, 2-16:1, 3-16:0, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3098: -1 - s_3219: 1 - s_3232: -1 @@ -62659,7 +66243,7 @@ - id: r_2559 - name: CL synthase (1-16:1, 2-16:1, 3-16:1, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3098: -1 - s_3219: 1 - s_3233: -1 @@ -62677,7 +66261,7 @@ - id: r_2560 - name: CL synthase (1-18:0, 2-16:1, 3-16:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3100: -1 - s_3219: 1 - s_3227: -1 @@ -62695,7 +66279,7 @@ - id: r_2561 - name: CL synthase (1-18:0, 2-16:1, 3-16:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3100: -1 - s_3219: 1 - s_3229: -1 @@ -62713,7 +66297,7 @@ - id: r_2562 - name: CL synthase (1-18:0, 2-16:1, 3-18:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3100: -1 - s_3219: 1 - s_3230: -1 @@ -62731,7 +66315,7 @@ - id: r_2563 - name: CL synthase (1-18:0, 2-16:1, 3-18:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3100: -1 - s_3219: 1 - s_3231: -1 @@ -62749,7 +66333,7 @@ - id: r_2564 - name: CL synthase (1-18:0, 2-16:1, 3-16:0, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3100: -1 - s_3219: 1 - s_3232: -1 @@ -62767,7 +66351,7 @@ - id: r_2565 - name: CL synthase (1-18:0, 2-16:1, 3-16:1, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3100: -1 - s_3219: 1 - s_3233: -1 @@ -62785,7 +66369,7 @@ - id: r_2566 - name: CL synthase (1-18:1, 2-16:1, 3-16:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3102: -1 - s_3219: 1 - s_3227: -1 @@ -62803,7 +66387,7 @@ - id: r_2567 - name: CL synthase (1-18:1, 2-16:1, 3-16:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3102: -1 - s_3219: 1 - s_3229: -1 @@ -62821,7 +66405,7 @@ - id: r_2568 - name: CL synthase (1-18:1, 2-16:1, 3-18:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3102: -1 - s_3219: 1 - s_3230: -1 @@ -62839,7 +66423,7 @@ - id: r_2569 - name: CL synthase (1-18:1, 2-16:1, 3-18:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3102: -1 - s_3219: 1 - s_3231: -1 @@ -62857,7 +66441,7 @@ - id: r_2570 - name: CL synthase (1-18:1, 2-16:1, 3-16:0, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3102: -1 - s_3219: 1 - s_3232: -1 @@ -62875,7 +66459,7 @@ - id: r_2571 - name: CL synthase (1-18:1, 2-16:1, 3-16:1, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3102: -1 - s_3219: 1 - s_3233: -1 @@ -62893,7 +66477,7 @@ - id: r_2572 - name: CL synthase (1-16:0, 2-18:1, 3-16:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3104: -1 - s_3219: 1 - s_3227: -1 @@ -62911,7 +66495,7 @@ - id: r_2573 - name: CL synthase (1-16:0, 2-18:1, 3-16:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3104: -1 - s_3219: 1 - s_3229: -1 @@ -62929,7 +66513,7 @@ - id: r_2574 - name: CL synthase (1-16:0, 2-18:1, 3-18:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3104: -1 - s_3219: 1 - s_3230: -1 @@ -62947,7 +66531,7 @@ - id: r_2575 - name: CL synthase (1-16:0, 2-18:1, 3-18:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3104: -1 - s_3219: 1 - s_3231: -1 @@ -62965,7 +66549,7 @@ - id: r_2576 - name: CL synthase (1-16:0, 2-18:1, 3-16:0, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3104: -1 - s_3219: 1 - s_3232: -1 @@ -62983,7 +66567,7 @@ - id: r_2577 - name: CL synthase (1-16:0, 2-18:1, 3-16:1, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3104: -1 - s_3219: 1 - s_3233: -1 @@ -63001,7 +66585,7 @@ - id: r_2578 - name: CL synthase (1-16:1, 2-18:1, 3-16:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3106: -1 - s_3219: 1 - s_3227: -1 @@ -63019,7 +66603,7 @@ - id: r_2579 - name: CL synthase (1-16:1, 2-18:1, 3-16:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3106: -1 - s_3219: 1 - s_3229: -1 @@ -63037,7 +66621,7 @@ - id: r_2580 - name: CL synthase (1-16:1, 2-18:1, 3-18:0, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3106: -1 - s_3219: 1 - s_3230: -1 @@ -63055,7 +66639,7 @@ - id: r_2581 - name: CL synthase (1-16:1, 2-18:1, 3-18:1, 4-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3106: -1 - s_3219: 1 - s_3231: -1 @@ -63073,7 +66657,7 @@ - id: r_2582 - name: CL synthase (1-16:1, 2-18:1, 3-16:0, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3106: -1 - s_3219: 1 - s_3232: -1 @@ -63091,7 +66675,7 @@ - id: r_2583 - name: CL synthase (1-16:1, 2-18:1, 3-16:1, 4-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3106: -1 - s_3219: 1 - s_3233: -1 @@ -67125,7 +70709,7 @@ - id: r_2820 - name: phosphatidylinositol 4-kinase (1-16:0, 2-16:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3323: -1 - s_3324: 1 @@ -67146,7 +70730,7 @@ - id: r_2821 - name: phosphatidylinositol 4-kinase (1-16:1, 2-16:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3326: -1 @@ -67167,7 +70751,7 @@ - id: r_2822 - name: phosphatidylinositol 4-kinase (1-18:0, 2-16:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3328: -1 @@ -67188,7 +70772,7 @@ - id: r_2823 - name: phosphatidylinositol 4-kinase (1-18:1, 2-16:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3330: -1 @@ -67209,7 +70793,7 @@ - id: r_2824 - name: phosphatidylinositol 4-kinase (1-16:0, 2-18:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3332: -1 @@ -67230,7 +70814,7 @@ - id: r_2825 - name: phosphatidylinositol 4-kinase (1-16:1, 2-18:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3334: -1 @@ -67251,7 +70835,7 @@ - id: r_2826 - name: phosphatidylinositol 4-kinase (1-18:0, 2-18:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3336: -1 @@ -67272,7 +70856,7 @@ - id: r_2827 - name: phosphatidylinositol 4-kinase (1-18:1, 2-18:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3338: -1 @@ -67293,7 +70877,7 @@ - id: r_2828 - name: phosphatidylinositol 4-kinase (1-16:0, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3340: -1 - s_3341: -1 - s_3342: 1 @@ -67313,7 +70897,7 @@ - id: r_2829 - name: phosphatidylinositol 4-kinase (1-16:1, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3344: -1 @@ -67333,7 +70917,7 @@ - id: r_2830 - name: phosphatidylinositol 4-kinase (1-18:0, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3346: -1 @@ -67353,7 +70937,7 @@ - id: r_2831 - name: phosphatidylinositol 4-kinase (1-18:1, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3348: -1 @@ -67373,7 +70957,7 @@ - id: r_2832 - name: phosphatidylinositol 4-kinase (1-16:0, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3350: -1 @@ -67393,7 +70977,7 @@ - id: r_2833 - name: phosphatidylinositol 4-kinase (1-16:1, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3352: -1 @@ -67413,7 +70997,7 @@ - id: r_2834 - name: phosphatidylinositol 4-kinase (1-18:0, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3354: -1 @@ -67433,7 +71017,7 @@ - id: r_2835 - name: phosphatidylinositol 4-kinase (1-18:1, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3356: -1 @@ -67453,7 +71037,7 @@ - id: r_2836 - name: phosphatidylinositol 4-kinase (1-16:0, 2-16:1), Golgi membrane - metabolites: !!omap - - s_3146: 1 + - s_3146: -1 - s_3358: -1 - s_3359: -1 - s_3360: 1 @@ -67473,7 +71057,7 @@ - id: r_2837 - name: phosphatidylinositol 4-kinase (1-16:1, 2-16:1), Golgi membrane - metabolites: !!omap - - s_3146: 1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3362: -1 @@ -67493,7 +71077,7 @@ - id: r_2838 - name: phosphatidylinositol 4-kinase (1-18:0, 2-16:1), Golgi membrane - metabolites: !!omap - - s_3146: 1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3364: -1 @@ -67513,7 +71097,7 @@ - id: r_2839 - name: phosphatidylinositol 4-kinase (1-18:1, 2-16:1), Golgi membrane - metabolites: !!omap - - s_3146: 1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3366: -1 @@ -67533,7 +71117,7 @@ - id: r_2840 - name: phosphatidylinositol 4-kinase (1-16:0, 2-18:1), Golgi membrane - metabolites: !!omap - - s_3146: 1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3368: -1 @@ -67553,7 +71137,7 @@ - id: r_2841 - name: phosphatidylinositol 4-kinase (1-16:1, 2-18:1), Golgi membrane - metabolites: !!omap - - s_3146: 1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3370: -1 @@ -67573,7 +71157,7 @@ - id: r_2842 - name: phosphatidylinositol 4-kinase (1-18:0, 2-18:1), Golgi membrane - metabolites: !!omap - - s_3146: 1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3372: -1 @@ -67593,7 +71177,7 @@ - id: r_2843 - name: phosphatidylinositol 4-kinase (1-18:1, 2-18:1), Golgi membrane - metabolites: !!omap - - s_3146: 1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3374: -1 @@ -67615,7 +71199,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3376: -1 - s_3377: 1 - lower_bound: 0 @@ -67635,7 +71219,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3378: -1 - s_3379: 1 - lower_bound: 0 @@ -67655,7 +71239,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3380: -1 - s_3381: 1 - lower_bound: 0 @@ -67675,7 +71259,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3382: -1 - s_3383: 1 - lower_bound: 0 @@ -67695,7 +71279,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3384: -1 - s_3385: 1 - lower_bound: 0 @@ -67715,7 +71299,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3386: -1 - s_3387: 1 - lower_bound: 0 @@ -67735,7 +71319,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3388: -1 - s_3389: 1 - lower_bound: 0 @@ -67755,7 +71339,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3390: -1 - s_3391: 1 - lower_bound: 0 @@ -67773,7 +71357,7 @@ - id: r_2852 - name: phosphatidylinositol 3-kinase (1-16:0, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3340: -1 - s_3341: -1 - s_3342: 1 @@ -67798,7 +71382,7 @@ - id: r_2853 - name: phosphatidylinositol 3-kinase (1-16:1, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3344: -1 @@ -67823,7 +71407,7 @@ - id: r_2854 - name: phosphatidylinositol 3-kinase (1-18:0, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3346: -1 @@ -67848,7 +71432,7 @@ - id: r_2855 - name: phosphatidylinositol 3-kinase (1-18:1, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3348: -1 @@ -67873,7 +71457,7 @@ - id: r_2856 - name: phosphatidylinositol 3-kinase (1-16:0, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3350: -1 @@ -67898,7 +71482,7 @@ - id: r_2857 - name: phosphatidylinositol 3-kinase (1-16:1, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3352: -1 @@ -67923,7 +71507,7 @@ - id: r_2858 - name: phosphatidylinositol 3-kinase (1-18:0, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3354: -1 @@ -67948,7 +71532,7 @@ - id: r_2859 - name: phosphatidylinositol 3-kinase (1-18:1, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3356: -1 @@ -67975,7 +71559,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3377: -1 - s_3400: 1 - lower_bound: 0 @@ -67998,7 +71582,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3379: -1 - s_3401: 1 - lower_bound: 0 @@ -68021,7 +71605,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3381: -1 - s_3402: 1 - lower_bound: 0 @@ -68044,7 +71628,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3383: -1 - s_3403: 1 - lower_bound: 0 @@ -68067,7 +71651,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3385: -1 - s_3404: 1 - lower_bound: 0 @@ -68090,7 +71674,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3387: -1 - s_3405: 1 - lower_bound: 0 @@ -68113,7 +71697,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3389: -1 - s_3406: 1 - lower_bound: 0 @@ -68136,7 +71720,7 @@ - metabolites: !!omap - s_0398: 1 - s_0438: -1 - - s_0800: 1 + - s_0800: -1 - s_3391: -1 - s_3407: 1 - lower_bound: 0 @@ -68157,7 +71741,7 @@ - id: r_2868 - name: PI 4-P 5-kinase (1-16:0, 2-16:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3325: -1 @@ -68180,7 +71764,7 @@ - id: r_2869 - name: PI 4-P 5-kinase (1-16:1, 2-16:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3327: -1 @@ -68203,7 +71787,7 @@ - id: r_2870 - name: PI 4-P 5-kinase (1-18:0, 2-16:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3329: -1 @@ -68226,7 +71810,7 @@ - id: r_2871 - name: PI 4-P 5-kinase (1-18:1, 2-16:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3331: -1 @@ -68249,7 +71833,7 @@ - id: r_2872 - name: PI 4-P 5-kinase (1-16:0, 2-18:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3333: -1 @@ -68272,7 +71856,7 @@ - id: r_2873 - name: PI 4-P 5-kinase (1-16:1, 2-18:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3335: -1 @@ -68295,7 +71879,7 @@ - id: r_2874 - name: PI 4-P 5-kinase (1-18:0, 2-18:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3337: -1 @@ -68318,7 +71902,7 @@ - id: r_2875 - name: PI 4-P 5-kinase (1-18:1, 2-18:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: -1 - s_2856: -1 - s_3324: 1 - s_3339: -1 @@ -68341,7 +71925,7 @@ - id: r_2876 - name: PI 3-P 5-kinase (1-16:0, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3392: -1 @@ -68362,7 +71946,7 @@ - id: r_2877 - name: PI 3-P 5-kinase (1-16:1, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3393: -1 @@ -68383,7 +71967,7 @@ - id: r_2878 - name: PI 3-P 5-kinase (1-18:0, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3394: -1 @@ -68404,7 +71988,7 @@ - id: r_2879 - name: PI 3-P 5-kinase (1-18:1, 2-16:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3395: -1 @@ -68425,7 +72009,7 @@ - id: r_2880 - name: PI 3-P 5-kinase (1-16:0, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3396: -1 @@ -68446,7 +72030,7 @@ - id: r_2881 - name: PI 3-P 5-kinase (1-16:1, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3397: -1 @@ -68467,7 +72051,7 @@ - id: r_2882 - name: PI 3-P 5-kinase (1-18:0, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3398: -1 @@ -68488,7 +72072,7 @@ - id: r_2883 - name: PI 3-P 5-kinase (1-18:1, 2-18:1), vacuolar membrane - metabolites: !!omap - - s_3164: 1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3399: -1 @@ -71693,7 +75277,7 @@ - id: r_3078 - name: LPI phospholipase B (16:0), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: 2 - s_3449: -1 - s_3463: 1 - s_3491: -1 @@ -71711,7 +75295,7 @@ - id: r_3079 - name: LPI phospholipase B (16:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: 2 - s_3449: -1 - s_3451: 1 - s_3492: -1 @@ -71729,7 +75313,7 @@ - id: r_3080 - name: LPI phospholipase B (18:0), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: 2 - s_3449: -1 - s_3464: 1 - s_3493: -1 @@ -71747,7 +75331,7 @@ - id: r_3081 - name: LPI phospholipase B (18:1), cell envelope - metabolites: !!omap - - s_0793: 1 + - s_0793: 2 - s_3449: -1 - s_3459: 1 - s_3494: -1 @@ -71765,7 +75349,7 @@ - id: r_3082 - name: PI 4,5-P2 phospholipase C (1-16:0, 2-16:1), cytoplasm - metabolites: !!omap - - s_0794: 1 + - s_0794: 6 - s_0803: -1 - s_3496: -1 - s_3497: 1 @@ -71786,7 +75370,7 @@ - id: r_3083 - name: PI 4,5-P2 phospholipase C (1-16:1, 2-16:1), cytoplasm - metabolites: !!omap - - s_0794: 1 + - s_0794: 6 - s_0803: -1 - s_3498: 1 - s_3499: -1 @@ -71807,7 +75391,7 @@ - id: r_3084 - name: PI 4,5-P2 phospholipase C (1-18:0, 2-16:1), cytoplasm - metabolites: !!omap - - s_0794: 1 + - s_0794: 6 - s_0803: -1 - s_3498: 1 - s_3501: -1 @@ -71828,7 +75412,7 @@ - id: r_3085 - name: PI 4,5-P2 phospholipase C (1-18:1, 2-16:1), cytoplasm - metabolites: !!omap - - s_0794: 1 + - s_0794: 6 - s_0803: -1 - s_3498: 1 - s_3503: -1 @@ -71849,7 +75433,7 @@ - id: r_3086 - name: PI 4,5-P2 phospholipase C (1-16:0, 2-18:1), cytoplasm - metabolites: !!omap - - s_0794: 1 + - s_0794: 6 - s_0803: -1 - s_3498: 1 - s_3505: -1 @@ -71870,7 +75454,7 @@ - id: r_3087 - name: PI 4,5-P2 phospholipase C (1-16:1, 2-18:1), cytoplasm - metabolites: !!omap - - s_0794: 1 + - s_0794: 6 - s_0803: -1 - s_3498: 1 - s_3507: -1 @@ -71891,7 +75475,7 @@ - id: r_3088 - name: PI 4,5-P2 phospholipase C (1-18:0, 2-18:1), cytoplasm - metabolites: !!omap - - s_0794: 1 + - s_0794: 6 - s_0803: -1 - s_3498: 1 - s_3509: -1 @@ -71912,7 +75496,7 @@ - id: r_3089 - name: PI 4,5-P2 phospholipase C (1-18:1, 2-18:1), cytoplasm - metabolites: !!omap - - s_0794: 1 + - s_0794: 6 - s_0803: -1 - s_3498: 1 - s_3511: -1 @@ -71934,7 +75518,7 @@ - name: PI 4,5-P2 phospholipase C (1-16:0, 2-16:1), nucleus - metabolites: !!omap - s_0125: 1 - - s_0800: 1 + - s_0800: 6 - s_0808: -1 - s_3400: -1 - s_3513: 1 @@ -71955,7 +75539,7 @@ - name: PI 4,5-P2 phospholipase C (1-16:1, 2-16:1), nucleus - metabolites: !!omap - s_0125: 1 - - s_0800: 1 + - s_0800: 6 - s_0808: -1 - s_3401: -1 - s_3514: 1 @@ -71976,7 +75560,7 @@ - name: PI 4,5-P2 phospholipase C (1-18:0, 2-16:1), nucleus - metabolites: !!omap - s_0125: 1 - - s_0800: 1 + - s_0800: 6 - s_0808: -1 - s_3402: -1 - s_3515: 1 @@ -71997,7 +75581,7 @@ - name: PI 4,5-P2 phospholipase C (1-18:1, 2-16:1), nucleus - metabolites: !!omap - s_0125: 1 - - s_0800: 1 + - s_0800: 6 - s_0808: -1 - s_3403: -1 - s_3516: 1 @@ -72018,7 +75602,7 @@ - name: PI 4,5-P2 phospholipase C (1-16:0, 2-18:1), nucleus - metabolites: !!omap - s_0125: 1 - - s_0800: 1 + - s_0800: 6 - s_0808: -1 - s_3404: -1 - s_3517: 1 @@ -72039,7 +75623,7 @@ - name: PI 4,5-P2 phospholipase C (1-16:1, 2-18:1), nucleus - metabolites: !!omap - s_0125: 1 - - s_0800: 1 + - s_0800: 6 - s_0808: -1 - s_3405: -1 - s_3518: 1 @@ -72060,7 +75644,7 @@ - name: PI 4,5-P2 phospholipase C (1-18:0, 2-18:1), nucleus - metabolites: !!omap - s_0125: 1 - - s_0800: 1 + - s_0800: 6 - s_0808: -1 - s_3406: -1 - s_3519: 1 @@ -72081,7 +75665,7 @@ - name: PI 4,5-P2 phospholipase C (1-18:1, 2-18:1), nucleus - metabolites: !!omap - s_0125: 1 - - s_0800: 1 + - s_0800: 6 - s_0808: -1 - s_3407: -1 - s_3520: 1 @@ -72101,7 +75685,7 @@ - id: r_3098 - name: PG phospholipase C (1-16:0, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3218: 1 - s_3226: -1 - s_3227: -1 @@ -72119,7 +75703,7 @@ - id: r_3099 - name: PG phospholipase C (1-16:1, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3218: 1 - s_3226: -1 - s_3229: -1 @@ -72137,7 +75721,7 @@ - id: r_3100 - name: PG phospholipase C (1-18:0, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3218: 1 - s_3226: -1 - s_3230: -1 @@ -72155,7 +75739,7 @@ - id: r_3101 - name: PG phospholipase C (1-18:1, 2-16:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3218: 1 - s_3226: -1 - s_3231: -1 @@ -72173,7 +75757,7 @@ - id: r_3102 - name: PG phospholipase C (1-16:0, 2-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3218: 1 - s_3226: -1 - s_3232: -1 @@ -72191,7 +75775,7 @@ - id: r_3103 - name: PG phospholipase C (1-16:1, 2-18:1), mitochondrial membrane - metabolites: !!omap - - s_3094: 1 + - s_3094: 2 - s_3218: 1 - s_3226: -1 - s_3233: -1 @@ -72210,7 +75794,7 @@ - name: PC phospholipase D (1-16:0, 2-16:1), cell envelope - metabolites: !!omap - s_0511: 1 - - s_0793: 1 + - s_0793: -1 - s_3448: -1 - s_3449: -1 - s_3527: 1 @@ -72231,7 +75815,7 @@ - name: PC phospholipase D (1-16:1, 2-16:1), cell envelope - metabolites: !!omap - s_0511: 1 - - s_0793: 1 + - s_0793: -1 - s_3449: -1 - s_3452: -1 - s_3528: 1 @@ -72252,7 +75836,7 @@ - name: PC phospholipase D (1-18:0, 2-16:1), cell envelope - metabolites: !!omap - s_0511: 1 - - s_0793: 1 + - s_0793: -1 - s_3449: -1 - s_3454: -1 - s_3529: 1 @@ -72273,7 +75857,7 @@ - name: PC phospholipase D (1-18:1, 2-16:1), cell envelope - metabolites: !!omap - s_0511: 1 - - s_0793: 1 + - s_0793: -1 - s_3449: -1 - s_3456: -1 - s_3530: 1 @@ -72294,7 +75878,7 @@ - name: PC phospholipase D (1-16:0, 2-18:1), cell envelope - metabolites: !!omap - s_0511: 1 - - s_0793: 1 + - s_0793: -1 - s_3449: -1 - s_3458: -1 - s_3531: 1 @@ -72315,7 +75899,7 @@ - name: PC phospholipase D (1-16:1, 2-18:1), cell envelope - metabolites: !!omap - s_0511: 1 - - s_0793: 1 + - s_0793: -1 - s_3449: -1 - s_3460: -1 - s_3532: 1 @@ -72336,7 +75920,7 @@ - name: PC phospholipase D (1-18:0, 2-18:1), cell envelope - metabolites: !!omap - s_0511: 1 - - s_0793: 1 + - s_0793: -1 - s_3449: -1 - s_3461: -1 - s_3533: 1 @@ -72357,7 +75941,7 @@ - name: PC phospholipase D (1-18:1, 2-18:1), cell envelope - metabolites: !!omap - s_0511: 1 - - s_0793: 1 + - s_0793: -1 - s_3449: -1 - s_3462: -1 - s_3534: 1 @@ -72377,6 +75961,7 @@ - id: r_3112 - name: PI 3-P phosphatase (1-16:0, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3323: 1 - s_3449: -1 - s_3535: -1 @@ -72398,6 +75983,7 @@ - id: r_3113 - name: PI 3-P phosphatase (1-16:1, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3326: 1 - s_3449: -1 - s_3536: 1 @@ -72419,6 +76005,7 @@ - id: r_3114 - name: PI 3-P phosphatase (1-18:0, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3328: 1 - s_3449: -1 - s_3536: 1 @@ -72440,6 +76027,7 @@ - id: r_3115 - name: PI 3-P phosphatase (1-18:1, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3330: 1 - s_3449: -1 - s_3536: 1 @@ -72461,6 +76049,7 @@ - id: r_3116 - name: PI 3-P phosphatase (1-16:0, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3332: 1 - s_3449: -1 - s_3536: 1 @@ -72482,6 +76071,7 @@ - id: r_3117 - name: PI 3-P phosphatase (1-16:1, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3334: 1 - s_3449: -1 - s_3536: 1 @@ -72503,6 +76093,7 @@ - id: r_3118 - name: PI 3-P phosphatase (1-18:0, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3336: 1 - s_3449: -1 - s_3536: 1 @@ -72524,6 +76115,7 @@ - id: r_3119 - name: PI 3-P phosphatase (1-18:1, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3338: 1 - s_3449: -1 - s_3536: 1 @@ -72545,6 +76137,7 @@ - id: r_3120 - name: PI 3-P phosphatase (1-16:0, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3544: -1 @@ -72568,6 +76161,7 @@ - id: r_3121 - name: PI 3-P phosphatase (1-16:1, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3546: -1 @@ -72584,6 +76178,7 @@ - 3.1.3.- - 3.1.3.36 - 3.1.3.64 + - bigg.reaction: PIP3P_HDE_HDE_c - pmid: 22345606 - sbo: SBO:0000176 - confidence_score: 3 @@ -72591,6 +76186,7 @@ - id: r_3122 - name: PI 3-P phosphatase (1-18:0, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3548: -1 @@ -72614,6 +76210,7 @@ - id: r_3123 - name: PI 3-P phosphatase (1-18:1, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3550: -1 @@ -72637,6 +76234,7 @@ - id: r_3124 - name: PI 3-P phosphatase (1-16:0, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3552: -1 @@ -72660,6 +76258,7 @@ - id: r_3125 - name: PI 3-P phosphatase (1-16:1, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3554: -1 @@ -72683,6 +76282,7 @@ - id: r_3126 - name: PI 3-P phosphatase (1-18:0, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3556: -1 @@ -72706,6 +76306,7 @@ - id: r_3127 - name: PI 3-P phosphatase (1-18:1, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3558: -1 @@ -72729,6 +76330,7 @@ - id: r_3128 - name: PI 3-P phosphatase (1-16:0, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3118: 1 @@ -72748,6 +76350,7 @@ - id: r_3129 - name: PI 3-P phosphatase (1-16:1, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3119: 1 @@ -72767,6 +76370,7 @@ - id: r_3130 - name: PI 3-P phosphatase (1-18:0, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3120: 1 @@ -72786,6 +76390,7 @@ - id: r_3131 - name: PI 3-P phosphatase (1-18:1, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3121: 1 @@ -72805,6 +76410,7 @@ - id: r_3132 - name: PI 3-P phosphatase (1-16:0, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3122: 1 @@ -72824,6 +76430,7 @@ - id: r_3133 - name: PI 3-P phosphatase (1-16:1, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3123: 1 @@ -72843,6 +76450,7 @@ - id: r_3134 - name: PI 3-P phosphatase (1-18:0, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3124: 1 @@ -72862,6 +76470,7 @@ - id: r_3135 - name: PI 3-P phosphatase (1-18:1, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3125: 1 @@ -72883,6 +76492,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3358: 1 - s_3568: -1 - lower_bound: 0 @@ -72902,6 +76512,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3362: 1 - s_3569: -1 - lower_bound: 0 @@ -72921,6 +76532,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3364: 1 - s_3570: -1 - lower_bound: 0 @@ -72940,6 +76552,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3366: 1 - s_3571: -1 - lower_bound: 0 @@ -72959,6 +76572,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3368: 1 - s_3572: -1 - lower_bound: 0 @@ -72978,6 +76592,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3370: 1 - s_3573: -1 - lower_bound: 0 @@ -72997,6 +76612,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3372: 1 - s_3574: -1 - lower_bound: 0 @@ -73016,6 +76632,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3374: 1 - s_3575: -1 - lower_bound: 0 @@ -73033,6 +76650,7 @@ - id: r_3144 - name: PI 4-P phosphatase (1-16:0, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3323: 1 - s_3325: -1 - s_3449: -1 @@ -73054,6 +76672,7 @@ - id: r_3145 - name: PI 4-P phosphatase (1-16:1, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3326: 1 - s_3327: -1 - s_3449: -1 @@ -73075,6 +76694,7 @@ - id: r_3146 - name: PI 4-P phosphatase (1-18:0, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3328: 1 - s_3329: -1 - s_3449: -1 @@ -73096,6 +76716,7 @@ - id: r_3147 - name: PI 4-P phosphatase (1-18:1, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3330: 1 - s_3331: -1 - s_3449: -1 @@ -73117,6 +76738,7 @@ - id: r_3148 - name: PI 4-P phosphatase (1-16:0, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3332: 1 - s_3333: -1 - s_3449: -1 @@ -73138,6 +76760,7 @@ - id: r_3149 - name: PI 4-P phosphatase (1-16:1, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3334: 1 - s_3335: -1 - s_3449: -1 @@ -73159,6 +76782,7 @@ - id: r_3150 - name: PI 4-P phosphatase (1-18:0, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3336: 1 - s_3337: -1 - s_3449: -1 @@ -73180,6 +76804,7 @@ - id: r_3151 - name: PI 4-P phosphatase (1-18:1, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3338: 1 - s_3339: -1 - s_3449: -1 @@ -73201,6 +76826,7 @@ - id: r_3152 - name: PI 4-P phosphatase (1-16:0, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3545: 1 @@ -73222,6 +76848,7 @@ - id: r_3153 - name: PI 4-P phosphatase (1-16:1, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3547: 1 @@ -73243,6 +76870,7 @@ - id: r_3154 - name: PI 4-P phosphatase (1-18:0, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3549: 1 @@ -73264,6 +76892,7 @@ - id: r_3155 - name: PI 4-P phosphatase (1-18:1, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3551: 1 @@ -73285,6 +76914,7 @@ - id: r_3156 - name: PI 4-P phosphatase (1-16:0, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3553: 1 @@ -73306,6 +76936,7 @@ - id: r_3157 - name: PI 4-P phosphatase (1-16:1, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3555: 1 @@ -73327,6 +76958,7 @@ - id: r_3158 - name: PI 4-P phosphatase (1-18:0, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3557: 1 @@ -73348,6 +76980,7 @@ - id: r_3159 - name: PI 4-P phosphatase (1-18:1, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3559: 1 @@ -73369,6 +77002,7 @@ - id: r_3160 - name: PI 4-P phosphatase (1-16:0, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3118: 1 @@ -73388,6 +77022,7 @@ - id: r_3161 - name: PI 4-P phosphatase (1-16:1, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3119: 1 @@ -73407,6 +77042,7 @@ - id: r_3162 - name: PI 4-P phosphatase (1-18:0, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3120: 1 @@ -73426,6 +77062,7 @@ - id: r_3163 - name: PI 4-P phosphatase (1-18:1, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3121: 1 @@ -73445,6 +77082,7 @@ - id: r_3164 - name: PI 4-P phosphatase (1-16:0, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3122: 1 @@ -73464,6 +77102,7 @@ - id: r_3165 - name: PI 4-P phosphatase (1-16:1, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3123: 1 @@ -73483,6 +77122,7 @@ - id: r_3166 - name: PI 4-P phosphatase (1-18:0, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3124: 1 @@ -73502,6 +77142,7 @@ - id: r_3167 - name: PI 4-P phosphatase (1-18:1, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3125: 1 @@ -73523,6 +77164,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3358: 1 - s_3361: -1 - lower_bound: 0 @@ -73542,6 +77184,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3362: 1 - s_3363: -1 - lower_bound: 0 @@ -73561,6 +77204,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3364: 1 - s_3365: -1 - lower_bound: 0 @@ -73580,6 +77224,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3366: 1 - s_3367: -1 - lower_bound: 0 @@ -73599,6 +77244,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3368: 1 - s_3369: -1 - lower_bound: 0 @@ -73618,6 +77264,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3370: 1 - s_3371: -1 - lower_bound: 0 @@ -73637,6 +77284,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3372: 1 - s_3373: -1 - lower_bound: 0 @@ -73656,6 +77304,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3374: 1 - s_3375: -1 - lower_bound: 0 @@ -73673,6 +77322,7 @@ - id: r_3176 - name: PI 3,5-P2 phosphatase (1-16:0, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3449: -1 - s_3535: 1 - s_3536: 1 @@ -73694,6 +77344,7 @@ - id: r_3177 - name: PI 3,5-P2 phosphatase (1-16:1, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3449: -1 - s_3536: 1 - s_3537: 1 @@ -73715,6 +77366,7 @@ - id: r_3178 - name: PI 3,5-P2 phosphatase (1-18:0, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3449: -1 - s_3536: 1 - s_3538: 1 @@ -73736,6 +77388,7 @@ - id: r_3179 - name: PI 3,5-P2 phosphatase (1-18:1, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3449: -1 - s_3536: 1 - s_3539: 1 @@ -73757,6 +77410,7 @@ - id: r_3180 - name: PI 3,5-P2 phosphatase (1-16:0, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3449: -1 - s_3536: 1 - s_3540: 1 @@ -73778,6 +77432,7 @@ - id: r_3181 - name: PI 3,5-P2 phosphatase (1-16:1, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3449: -1 - s_3536: 1 - s_3541: 1 @@ -73799,6 +77454,7 @@ - id: r_3182 - name: PI 3,5-P2 phosphatase (1-18:0, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3449: -1 - s_3536: 1 - s_3542: 1 @@ -73820,6 +77476,7 @@ - id: r_3183 - name: PI 3,5-P2 phosphatase (1-18:1, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3449: -1 - s_3536: 1 - s_3543: 1 @@ -73841,6 +77498,7 @@ - id: r_3184 - name: PI 3,5-P2 phosphatase (1-16:0, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3544: 1 @@ -73862,6 +77520,7 @@ - id: r_3185 - name: PI 3,5-P2 phosphatase (1-16:1, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3546: 1 @@ -73883,6 +77542,7 @@ - id: r_3186 - name: PI 3,5-P2 phosphatase (1-18:0, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3548: 1 @@ -73904,6 +77564,7 @@ - id: r_3187 - name: PI 3,5-P2 phosphatase (1-18:1, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3550: 1 @@ -73925,6 +77586,7 @@ - id: r_3188 - name: PI 3,5-P2 phosphatase (1-16:0, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3552: 1 @@ -73946,6 +77608,7 @@ - id: r_3189 - name: PI 3,5-P2 phosphatase (1-16:1, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3554: 1 @@ -73967,6 +77630,7 @@ - id: r_3190 - name: PI 3,5-P2 phosphatase (1-18:0, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3556: 1 @@ -73988,6 +77652,7 @@ - id: r_3191 - name: PI 3,5-P2 phosphatase (1-18:1, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3558: 1 @@ -74009,6 +77674,7 @@ - id: r_3192 - name: PI 4,5-P2 phosphatase (1-16:0, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3325: 1 - s_3408: -1 - s_3449: -1 @@ -74030,6 +77696,7 @@ - id: r_3193 - name: PI 4,5-P2 phosphatase (1-16:1, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3327: 1 - s_3409: -1 - s_3449: -1 @@ -74051,6 +77718,7 @@ - id: r_3194 - name: PI 4,5-P2 phosphatase (1-18:0, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3329: 1 - s_3410: -1 - s_3449: -1 @@ -74072,6 +77740,7 @@ - id: r_3195 - name: PI 4,5-P2 phosphatase (1-18:1, 2-16:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3331: 1 - s_3411: -1 - s_3449: -1 @@ -74093,6 +77762,7 @@ - id: r_3196 - name: PI 4,5-P2 phosphatase (1-16:0, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3333: 1 - s_3412: -1 - s_3449: -1 @@ -74114,6 +77784,7 @@ - id: r_3197 - name: PI 4,5-P2 phosphatase (1-16:1, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3335: 1 - s_3413: -1 - s_3449: -1 @@ -74135,6 +77806,7 @@ - id: r_3198 - name: PI 4,5-P2 phosphatase (1-18:0, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3337: 1 - s_3414: -1 - s_3449: -1 @@ -74156,6 +77828,7 @@ - id: r_3199 - name: PI 4,5-P2 phosphatase (1-18:1, 2-18:1), cell envelope - metabolites: !!omap + - s_0793: 2 - s_3339: 1 - s_3415: -1 - s_3449: -1 @@ -74177,6 +77850,7 @@ - id: r_3200 - name: PI 4,5-P2 phosphatase (1-16:0, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3496: -1 @@ -74198,6 +77872,7 @@ - id: r_3201 - name: PI 4,5-P2 phosphatase (1-16:1, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3499: -1 @@ -74219,6 +77894,7 @@ - id: r_3202 - name: PI 4,5-P2 phosphatase (1-18:0, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3501: -1 @@ -74240,6 +77916,7 @@ - id: r_3203 - name: PI 4,5-P2 phosphatase (1-18:1, 2-16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3503: -1 @@ -74261,6 +77938,7 @@ - id: r_3204 - name: PI 4,5-P2 phosphatase (1-16:0, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3505: -1 @@ -74282,6 +77960,7 @@ - id: r_3205 - name: PI 4,5-P2 phosphatase (1-16:1, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3507: -1 @@ -74303,6 +77982,7 @@ - id: r_3206 - name: PI 4,5-P2 phosphatase (1-18:0, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3509: -1 @@ -74324,6 +78004,7 @@ - id: r_3207 - name: PI 4,5-P2 phosphatase (1-18:1, 2-18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3511: -1 @@ -74345,6 +78026,7 @@ - id: r_3208 - name: PI 4,5-P2 phosphatase (1-16:0, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3584: 1 @@ -74364,6 +78046,7 @@ - id: r_3209 - name: PI 4,5-P2 phosphatase (1-16:1, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3585: 1 @@ -74383,6 +78066,7 @@ - id: r_3210 - name: PI 4,5-P2 phosphatase (1-18:0, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3586: 1 @@ -74402,6 +78086,7 @@ - id: r_3211 - name: PI 4,5-P2 phosphatase (1-18:1, 2-16:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3587: 1 @@ -74421,6 +78106,7 @@ - id: r_3212 - name: PI 4,5-P2 phosphatase (1-16:0, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3588: 1 @@ -74440,6 +78126,7 @@ - id: r_3213 - name: PI 4,5-P2 phosphatase (1-16:1, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3589: 1 @@ -74459,6 +78146,7 @@ - id: r_3214 - name: PI 4,5-P2 phosphatase (1-18:0, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3590: 1 @@ -74478,6 +78166,7 @@ - id: r_3215 - name: PI 4,5-P2 phosphatase (1-18:1, 2-18:1), ER membrane - metabolites: !!omap + - s_2783: 2 - s_2808: -1 - s_2966: 1 - s_3591: 1 @@ -74499,6 +78188,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3392: 1 - s_3416: -1 - lower_bound: 0 @@ -74515,6 +78205,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3393: 1 - s_3417: -1 - lower_bound: 0 @@ -74531,6 +78222,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3394: 1 - s_3418: -1 - lower_bound: 0 @@ -74547,6 +78239,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3395: 1 - s_3419: -1 - lower_bound: 0 @@ -74563,6 +78256,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3396: 1 - s_3420: -1 - lower_bound: 0 @@ -74579,6 +78273,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3397: 1 - s_3421: -1 - lower_bound: 0 @@ -74595,6 +78290,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3398: 1 - s_3422: -1 - lower_bound: 0 @@ -74611,6 +78307,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3399: 1 - s_3423: -1 - lower_bound: 0 @@ -74628,7 +78325,7 @@ - s_2975: 1 - s_2976: -1 - s_2977: 1 - - s_3164: 1 + - s_3164: 2 - s_3616: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74651,7 +78348,7 @@ - s_2976: -1 - s_2977: 1 - s_2981: 1 - - s_3164: 1 + - s_3164: 2 - s_3617: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74674,7 +78371,7 @@ - s_2976: -1 - s_2977: 1 - s_2985: 1 - - s_3164: 1 + - s_3164: 2 - s_3618: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74697,7 +78394,7 @@ - s_2976: -1 - s_2977: 1 - s_2989: 1 - - s_3164: 1 + - s_3164: 2 - s_3619: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74720,7 +78417,7 @@ - s_2976: -1 - s_2977: 1 - s_2979: 1 - - s_3164: 1 + - s_3164: 2 - s_3620: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74743,7 +78440,7 @@ - s_2976: -1 - s_2977: 1 - s_2983: 1 - - s_3164: 1 + - s_3164: 2 - s_3621: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74766,7 +78463,7 @@ - s_2976: -1 - s_2977: 1 - s_2987: 1 - - s_3164: 1 + - s_3164: 2 - s_3622: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74789,7 +78486,7 @@ - s_2976: -1 - s_2977: 1 - s_2991: 1 - - s_3164: 1 + - s_3164: 2 - s_3623: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74812,7 +78509,7 @@ - s_2993: 1 - s_2994: -1 - s_2995: 1 - - s_3146: 1 + - s_3146: 2 - s_3624: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74831,7 +78528,7 @@ - s_2994: -1 - s_2995: 1 - s_2999: 1 - - s_3146: 1 + - s_3146: 2 - s_3625: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74850,7 +78547,7 @@ - s_2994: -1 - s_2995: 1 - s_3003: 1 - - s_3146: 1 + - s_3146: 2 - s_3626: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74869,7 +78566,7 @@ - s_2994: -1 - s_2995: 1 - s_3007: 1 - - s_3146: 1 + - s_3146: 2 - s_3627: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74888,7 +78585,7 @@ - s_2994: -1 - s_2995: 1 - s_2997: 1 - - s_3146: 1 + - s_3146: 2 - s_3628: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74907,7 +78604,7 @@ - s_2994: -1 - s_2995: 1 - s_3001: 1 - - s_3146: 1 + - s_3146: 2 - s_3629: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74926,7 +78623,7 @@ - s_2994: -1 - s_2995: 1 - s_3005: 1 - - s_3146: 1 + - s_3146: 2 - s_3630: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74945,7 +78642,7 @@ - s_2994: -1 - s_2995: 1 - s_3009: 1 - - s_3146: 1 + - s_3146: 2 - s_3631: -1 - lower_bound: 0 - upper_bound: 1000 @@ -74961,6 +78658,7 @@ - id: r_3240 - name: lysoPA phosphatase (16:0), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3632: -1 @@ -74976,6 +78674,7 @@ - id: r_3241 - name: lysoPA phosphatase (16:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3634: -1 @@ -74991,6 +78690,7 @@ - id: r_3242 - name: lysoPA phosphatase (18:0), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3636: -1 @@ -75006,6 +78706,7 @@ - id: r_3243 - name: lysoPA phosphatase (18:1), cytoplasm - metabolites: !!omap + - s_0794: 2 - s_0803: -1 - s_1322: 1 - s_3638: -1 @@ -75023,6 +78724,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3640: -1 - s_3641: 1 - lower_bound: 0 @@ -75045,6 +78747,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3642: -1 - s_3643: 1 - lower_bound: 0 @@ -75067,6 +78770,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3644: -1 - s_3645: 1 - lower_bound: 0 @@ -75089,6 +78793,7 @@ - metabolites: !!omap - s_2976: -1 - s_2977: 1 + - s_3164: 2 - s_3646: -1 - s_3647: 1 - lower_bound: 0 @@ -75111,6 +78816,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3648: -1 - s_3649: 1 - lower_bound: 0 @@ -75129,6 +78835,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3650: -1 - s_3651: 1 - lower_bound: 0 @@ -75147,6 +78854,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3652: -1 - s_3653: 1 - lower_bound: 0 @@ -75165,6 +78873,7 @@ - metabolites: !!omap - s_2994: -1 - s_2995: 1 + - s_3146: 2 - s_3654: -1 - s_3655: 1 - lower_bound: 0 @@ -76870,6 +80579,7 @@ - name: PA kinase (1-16:0, 2-16:1), Golgi membrane - metabolites: !!omap - s_2993: -1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3624: 1 @@ -76883,6 +80593,7 @@ - name: PA kinase (1-16:1, 2-16:1), Golgi membrane - metabolites: !!omap - s_2999: -1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3625: 1 @@ -76896,6 +80607,7 @@ - name: PA kinase (1-18:0, 2-16:1), Golgi membrane - metabolites: !!omap - s_3003: -1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3626: 1 @@ -76909,6 +80621,7 @@ - name: PA kinase (1-18:1, 2-16:1), Golgi membrane - metabolites: !!omap - s_3007: -1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3627: 1 @@ -76922,6 +80635,7 @@ - name: PA kinase (1-16:0, 2-18:1), Golgi membrane - metabolites: !!omap - s_2997: -1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3628: 1 @@ -76935,6 +80649,7 @@ - name: PA kinase (1-16:1, 2-18:1), Golgi membrane - metabolites: !!omap - s_3001: -1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3629: 1 @@ -76948,6 +80663,7 @@ - name: PA kinase (1-18:0, 2-18:1), Golgi membrane - metabolites: !!omap - s_3005: -1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3630: 1 @@ -76961,6 +80677,7 @@ - name: PA kinase (1-18:1, 2-18:1), Golgi membrane - metabolites: !!omap - s_3009: -1 + - s_3146: -1 - s_3359: -1 - s_3360: 1 - s_3631: 1 @@ -76974,6 +80691,7 @@ - name: PA kinase (1-16:0, 2-16:1), vacuolar membrane - metabolites: !!omap - s_2975: -1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3616: 1 @@ -76987,6 +80705,7 @@ - name: PA kinase (1-16:1, 2-16:1), vacuolar membrane - metabolites: !!omap - s_2981: -1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3617: 1 @@ -77000,6 +80719,7 @@ - name: PA kinase (1-18:0, 2-16:1), vacuolar membrane - metabolites: !!omap - s_2985: -1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3618: 1 @@ -77013,6 +80733,7 @@ - name: PA kinase (1-18:1, 2-16:1), vacuolar membrane - metabolites: !!omap - s_2989: -1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3619: 1 @@ -77026,6 +80747,7 @@ - name: PA kinase (1-16:0, 2-18:1), vacuolar membrane - metabolites: !!omap - s_2979: -1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3620: 1 @@ -77039,6 +80761,7 @@ - name: PA kinase (1-16:1, 2-18:1), vacuolar membrane - metabolites: !!omap - s_2983: -1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3621: 1 @@ -77052,6 +80775,7 @@ - name: PA kinase (1-18:0, 2-18:1), vacuolar membrane - metabolites: !!omap - s_2987: -1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3622: 1 @@ -77065,6 +80789,7 @@ - name: PA kinase (1-18:1, 2-18:1), vacuolar membrane - metabolites: !!omap - s_2991: -1 + - s_3164: -1 - s_3341: -1 - s_3342: 1 - s_3623: 1 @@ -86086,6 +89811,7 @@ - subsystem: sce00620 Pyruvate metabolism - annotation: !!omap - ec-code: 3.1.2.1 + - kegg.reaction: R10343 - metanetx.reaction: MNXR104636 - pmid: 19298859 - sbo: SBO:0000176 @@ -86128,6 +89854,7 @@ - name: raffinose invertase - metabolites: !!omap - s_0554: 1 + - s_0805: -1 - s_3715: -1 - s_3716: 1 - lower_bound: 0 @@ -86139,6 +89866,7 @@ - sce01230 Biosynthesis of amino acids - annotation: !!omap - ec-code: 5.3.1.16 + - kegg.reaction: R02410 - metanetx.reaction: MNXR103420 - pmid: 4967422 - sbo: SBO:0000176 @@ -86151,6 +89879,7 @@ - lower_bound: 0 - upper_bound: 1000 - annotation: !!omap + - bigg.reaction: EX_raffin_e - sbo: SBO:0000627 - !!omap - id: r_4044 @@ -86160,6 +89889,7 @@ - lower_bound: 0 - upper_bound: 1000 - annotation: !!omap + - bigg.reaction: EX_melib_e - sbo: SBO:0000627 - !!omap - id: r_4045 @@ -86177,6 +89907,8 @@ - sce00760 Nicotinate and nicotinamide metabolism - annotation: !!omap - ec-code: 3.2.2.3 + - bigg.reaction: URIH + - kegg.reaction: R01080 - metanetx.reaction: MNXR105161 - pmid: 23670538 - sbo: SBO:0000176 @@ -86193,6 +89925,7 @@ - lower_bound: 0.7 - upper_bound: 0.7 - annotation: !!omap + - bigg.reaction: ATPM - sbo: SBO:0000630 - confidence_score: 0 - !!omap @@ -87605,8 +91338,9 @@ - ec-code: - 4.4.1.17 - 4.4.1.- + - bigg.reaction: HEMELm - kegg.reaction: R02480 - - metanetx.reaction: MNXR100594 + - metanetx.reaction: MNXR138510 - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -87623,6 +91357,7 @@ - gene_reaction_rule: YAL061W - annotation: !!omap - ec-code: 1.1.1.303 + - bigg.reaction: ACTD - kegg.reaction: R02855 - metanetx.reaction: MNXR95419 - sbo: SBO:0000176 @@ -87651,7 +91386,7 @@ - metabolites: !!omap - s_0397: 1 - s_0437: -1 - - s_0799: 2 + - s_0799: 1 - s_0807: -1 - s_0993: 1 - s_1326: 1 @@ -87909,6 +91644,7 @@ - gene_reaction_rule: YBR281C and YNL191W - annotation: !!omap - ec-code: 3.4.-.- + - bigg.reaction: GTHRDH_syn - kegg.reaction: R03916 - metanetx.reaction: MNXR108524 - sbo: SBO:0000176 @@ -87929,6 +91665,7 @@ - gene_reaction_rule: YBR295W - annotation: !!omap - ec-code: 3.6.3.3 + - bigg.reaction: CD2abc1 - sbo: SBO:0000655 - confidence_score: 2 - !!omap @@ -88006,6 +91743,7 @@ - gene_reaction_rule: YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W - annotation: !!omap - ec-code: 1.1.1.- + - bigg.reaction: 3MBZALDH - kegg.reaction: R05347 - metanetx.reaction: MNXR94914 - sbo: SBO:0000176 @@ -88040,6 +91778,7 @@ - gene_reaction_rule: YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W - annotation: !!omap - ec-code: 1.1.1.- + - bigg.reaction: 4MBZALDH - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -88056,6 +91795,7 @@ - gene_reaction_rule: YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W - annotation: !!omap - ec-code: 1.1.1.- + - bigg.reaction: BZALDH - kegg.reaction: R01763 - metanetx.reaction: MNXR96362 - sbo: SBO:0000176 @@ -88092,6 +91832,7 @@ - gene_reaction_rule: YEL070W or YNR073C - annotation: !!omap - ec-code: 1.1.1.- + - bigg.reaction: MNLDH2 - kegg.reaction: R00868 - metanetx.reaction: MNXR101675 - sbo: SBO:0000176 @@ -88128,6 +91869,7 @@ - ec-code: - 4.1.3.17 - 4.1.1.3 + - bigg.reaction: OAADC - kegg.reaction: R00217 - metanetx.reaction: MNXR102097 - sbo: SBO:0000176 @@ -88136,6 +91878,7 @@ - id: r_4186 - name: L-methionine:thioredoxin-disulfide S-oxidoreductase - metabolites: !!omap + - s_0794: 1 - s_0803: -1 - s_1029: -1 - s_1616: 1 @@ -88181,6 +91924,7 @@ - gene_reaction_rule: YER163C - annotation: !!omap - ec-code: 4.3.2.- + - bigg.reaction: GGCLUT2 - kegg.reaction: R11861 - sbo: SBO:0000176 - confidence_score: 2 @@ -88197,7 +91941,7 @@ - annotation: !!omap - ec-code: 4.2.1.96 - kegg.reaction: R04734 - - metanetx.reaction: MNXR109090 + - metanetx.reaction: MNXR143540 - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -88213,6 +91957,7 @@ - gene_reaction_rule: YHR008C - annotation: !!omap - ec-code: 1.15.1.1 + - bigg.reaction: SPODMm - kegg.reaction: R00275 - metanetx.reaction: MNXR104498 - sbo: SBO:0000176 @@ -88230,6 +91975,7 @@ - gene_reaction_rule: YHR043C or YHR044C - annotation: !!omap - ec-code: 3.1.3.68 + - bigg.reaction: 2DOXG6PP - kegg.reaction: R02587 - metanetx.reaction: MNXR94794 - sbo: SBO:0000176 @@ -88326,6 +92072,7 @@ - gene_reaction_rule: YIL043C or YKL150W or YML125C - annotation: !!omap - ec-code: 1.6.2.2 + - bigg.reaction: FCYTOB5OXR_m - kegg.reaction: R00100 - metanetx.reaction: MNXR106388 - sbo: SBO:0000176 @@ -88360,7 +92107,7 @@ - annotation: !!omap - ec-code: 2.5.1.18 - kegg.reaction: R03522 - - metanetx.reaction: MNXR108227 + - metanetx.reaction: MNXR125877 - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -88377,7 +92124,7 @@ - annotation: !!omap - ec-code: 2.5.1.18 - kegg.reaction: R03522 - - metanetx.reaction: MNXR108227 + - metanetx.reaction: MNXR125877 - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -88394,13 +92141,14 @@ - annotation: !!omap - ec-code: 2.5.1.18 - kegg.reaction: R03522 - - metanetx.reaction: MNXR108227 + - metanetx.reaction: MNXR125877 - sbo: SBO:0000176 - confidence_score: 2 - !!omap - id: r_4202 - name: L-methionine:oxidized-thioredoxin S-oxidoreductase - metabolites: !!omap + - s_0794: 1 - s_0803: -1 - s_1029: -1 - s_1616: 1 @@ -88411,6 +92159,7 @@ - gene_reaction_rule: YKL069W - annotation: !!omap - ec-code: 1.8.4.14 + - bigg.reaction: METSOXR1 - kegg.reaction: R02025 - metanetx.reaction: MNXR101484 - sbo: SBO:0000176 @@ -88461,8 +92210,9 @@ - gene_reaction_rule: YKL215C - annotation: !!omap - ec-code: 3.5.2.9 + - bigg.reaction: OPAH - kegg.reaction: R00251 - - metanetx.reaction: MNXR102200 + - metanetx.reaction: MNXR138674 - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -88495,7 +92245,7 @@ - annotation: !!omap - ec-code: 2.5.1.18 - kegg.reaction: R03522 - - metanetx.reaction: MNXR108227 + - metanetx.reaction: MNXR125877 - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -88513,8 +92263,9 @@ - ec-code: - 2.5.1.18 - 1.8.5.1 + - bigg.reaction: GTHDH - kegg.reaction: R01108 - - metanetx.reaction: MNXR100442 + - metanetx.reaction: MNXR138490 - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -88533,7 +92284,7 @@ - 2.5.1.18 - 1.8.5.1 - kegg.reaction: R01108 - - metanetx.reaction: MNXR100442 + - metanetx.reaction: MNXR138490 - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -88572,7 +92323,7 @@ - 4.3.3.6 - 3.5.1.2 - kegg.reaction: R10089 - - metanetx.reaction: MNXR113465 + - metanetx.reaction: MNXR140225 - sbo: SBO:0000176 - confidence_score: 2 - !!omap @@ -88594,6 +92345,7 @@ - ec-code: - 4.3.3.6 - 3.5.1.2 + - bigg.reaction: PYDXS - kegg.reaction: R07456 - metanetx.reaction: MNXR103369 - sbo: SBO:0000176 @@ -88611,6 +92363,7 @@ - gene_reaction_rule: YFR044C - annotation: !!omap - ec-code: 3.4.13.- + - bigg.reaction: AMPTASECG - kegg.reaction: R00899 - metanetx.reaction: MNXR95828 - sbo: SBO:0000176 @@ -88645,6 +92398,7 @@ - gene_reaction_rule: YDL024C - annotation: !!omap - ec-code: 3.1.3.2 + - bigg.reaction: ACP1_FMN - kegg.reaction: R00548 - metanetx.reaction: MNXR95393 - sbo: SBO:0000176 @@ -88671,6 +92425,7 @@ - id: r_4218 - name: D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (EC 3.1.1.-) - metabolites: !!omap + - s_0794: 1 - s_0803: -1 - s_1003: 1 - s_1582: 1 @@ -88734,6 +92489,7 @@ - gene_reaction_rule: YDL246C - annotation: !!omap - ec-code: 1.1.1.14 + - bigg.reaction: RE1317C - kegg.reaction: R02896 - metanetx.reaction: MNXR107809 - sbo: SBO:0000176 @@ -88751,6 +92507,7 @@ - upper_bound: 1000 - gene_reaction_rule: YDR009W - annotation: !!omap + - bigg.reaction: GALK2 - kegg.reaction: R01092 - metanetx.reaction: MNXR99985 - sbo: SBO:0000176 @@ -88789,6 +92546,7 @@ - gene_reaction_rule: YDR038C or YDR039C or YDR040C - annotation: !!omap - ec-code: 3.6.3.7 + - bigg.reaction: NAabcO - sbo: SBO:0000655 - 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metanetx.reaction: MNXR109940 - sbo: SBO:0000176 - confidence_score: 2 - - !!omap - - id: r_4235 - - name: ATP:D-glucose 6-phosphotransferase - - metabolites: !!omap - - s_0394: 1 - - s_0434: -1 - - s_0563: -1 - - s_0568: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: YDR516C - - annotation: !!omap - - ec-code: 2.7.1.1 - - kegg.reaction: R00299 - - metanetx.reaction: MNXR100612 - - sbo: SBO:0000176 - - confidence_score: 2 - !!omap - id: r_4236 - name: (R)-lactate hydro-lyase @@ -88992,6 +92738,7 @@ - gene_reaction_rule: YDR533C or YMR322C or YOR391C or YPL280W - annotation: !!omap - ec-code: 4.2.1.130 + - bigg.reaction: GLYOX3 - kegg.reaction: R09796 - metanetx.reaction: MNXR100354 - sbo: SBO:0000176 @@ -89206,6 +92953,7 @@ - gene_reaction_rule: YGL196W - annotation: !!omap - ec-code: 4.3.1.18 + - bigg.reaction: SERD_D - kegg.reaction: R00221 - metanetx.reaction: MNXR104338 - sbo: SBO:0000176 @@ -89223,6 +92971,7 @@ - gene_reaction_rule: YGR012W - annotation: !!omap - 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sbo: SBO:0000627 - !!omap - id: r_4597 @@ -94066,6 +97981,7 @@ - lower_bound: -1000 - upper_bound: 1000 - annotation: !!omap + - bigg.reaction: EX_mg2_e - sbo: SBO:0000627 - !!omap - id: r_4598 @@ -94115,6 +98031,7 @@ - lower_bound: -1000 - upper_bound: 1000 - annotation: !!omap + - bigg.reaction: EX_ca2_e - sbo: SBO:0000627 - !!omap - id: r_4601 diff --git a/README.md b/README.md index a19ed465..cdbcbfcd 100644 --- a/README.md +++ b/README.md @@ -10,13 +10,13 @@ This repository contains the current consensus genome-scale metabolic model of _ **GEM Category:** species; **Utilisation:** experimental data reconstruction, multi-omics integrative analysis, _in silico_ strain design, model template; **Field:** metabolic-network reconstruction; **Type of Model:** reconstruction, curated; **Model Source:** YeastMetabolicNetwork; **Omic Source:** genomics, metabolomics; **Taxonomy:** _Saccharomyces cerevisiae_; **Metabolic System:** general metabolism; **Bioreactor**; **Strain:** S288C; **Condition:** aerobic, glucose-limited, defined media; -* Last update: 2020-03-31 +* Last update: 2020-06-12 * Main Model Descriptors: |Taxonomy | Template Model | Reactions | Metabolites| Genes | |:-------:|:--------------:|:---------:|:----------:|:-----:| -|_Saccharomyces cerevisiae_|[Yeast 7.6](https://sourceforge.net/projects/yeast/)|3991|2691|1147| +|_Saccharomyces cerevisiae_|[Yeast 7.6](https://sourceforge.net/projects/yeast/)|3989|2693|1147| This repository is administered by Benjamín J. Sánchez ([@BenjaSanchez](https://github.com/benjasanchez)), Division of Systems and Synthetic Biology, Department of Biology and Biological Engineering, Chalmers University of Technology. @@ -27,9 +27,7 @@ This repository is administered by Benjamín J. Sánchez ([@BenjaSanchez](https: * Matlab user: * A functional Matlab installation (MATLAB 7.3 or higher). * The [COBRA toolbox for MATLAB](https://github.com/opencobra/cobratoolbox). -* Python user: - * Python 2.7, 3.4, 3.5 or 3.6 - * [cobrapy](https://github.com/opencobra/cobrapy) +* Python user: Python 3.4, 3.5, 3.6 or 3.7 ### Required Software - Contributor: @@ -42,18 +40,28 @@ This repository is administered by Benjamín J. Sánchez ([@BenjaSanchez](https: * [Gurobi Optimizer](http://www.gurobi.com/registration/download-reg) for any simulations. ### Installation Instructions -* For users: Clone it from [`master`](https://github.com/SysBioChalmers/yeast-GEM) in the Github repo, or just download [the latest release](https://github.com/SysBioChalmers/yeast-GEM/releases). +* For users: Clone it from [`master`](https://github.com/SysBioChalmers/yeast-GEM) in the Github repo, or just download [the latest release](https://github.com/SysBioChalmers/yeast-GEM/releases). If you work in python, please create an environment with all requirements: + ```bash + pip install -r requirements.txt # installs all dependencies + type nul > .env # creates a .env file for locating the root + ``` * For contributors: Fork it to your Github account, and create a new branch from [`devel`](https://github.com/SysBioChalmers/yeast-GEM/tree/devel). ## Usage Make sure to load/save the model with the corresponding wrapper functions! * In Matlab: - * Loading: `complementaryScripts/loadYeastModel.m` - * Saving: `complementaryScripts/saveYeastModel.m` + ```matlab + cd ./ComplementaryScripts + model = loadYeastModel(); % loading + saveYeastModel(model); % saving + ``` * In Python: - * Loading: `complementaryScripts/loadYeastModel.py` - * Saving: currently unavailable + ```python + import ComplementaryScripts.io as io + model = io.read_yeast_model() # loading + io.write_yeast_model(model) # saving + ``` ## Model Files diff --git a/requirements.txt b/requirements.txt new file mode 100644 index 00000000..499a42f8 --- /dev/null +++ b/requirements.txt @@ -0,0 +1,142 @@ +alabaster==0.7.12 +arrow==0.15.5 +asn1crypto==1.3.0 +atomicwrites==1.3.0 +attrs==19.3.0 +Babel==2.8.0 +backcall==0.1.0 +binaryornot==0.4.4 +bleach==3.1.4 +boto3==1.12.42 +botocore==1.15.42 +certifi==2020.4.5.1 +cffi==1.14.0 +chardet==3.0.4 +click==7.1.1 +click-configfile==0.2.3 +click-default-group==1.2.2 +click-log==0.3.2 +cobra==0.17.1 +colorama==0.4.3 +configparser==5.0.0 +cookiecutter==1.7.2 +cryptography==2.5 +cycler==0.10.0 +datapackage==1.13.0 +decorator==4.4.2 +defusedxml==0.6.0 +depinfo==1.5.3 +docutils==0.15 +entrypoints==0.3 +equilibrator-api==0.1.26 +et-xmlfile==1.0.1 +future==0.18.2 +gitdb==4.0.4 +GitPython==3.1.1 +goodtables==2.4.12 +idna==2.9 +ijson==3.0.1 +imagesize==1.2.0 +importlib-metadata==1.6.0 +importlib-resources==1.4.0 +ipykernel==5.2.1 +ipython==7.13.0 +ipython-genutils==0.2.0 +isodate==0.6.0 +jdcal==1.4.1 +jedi==0.17.0 +Jinja2==2.11.2 +jinja2-time==0.2.0 +jmespath==0.9.5 +joblib==0.14.1 +jsonlines==1.2.0 +jsonpointer==2.0 +jsonschema==3.2.0 +jupyter-client==6.1.3 +jupyter-core==4.6.3 +kiwisolver==1.2.0 +linear-tsv==1.1.0 +lxml==4.5.0 +MarkupSafe==1.1.1 +matplotlib==3.2.1 +memote==0.10.2 +mistune==0.8.4 +more-itertools==8.2.0 +mpmath==1.1.0 +nbconvert==5.6.1 +nbformat==5.0.6 +nltk==3.5 +notebook==6.0.3 +numpy==1.18.3 +numpydoc==0.9.2 +openpyxl==3.0.3 +optlang==1.4.4 +packaging==20.3 +pandas==1.0.3 +pandocfilters==1.4.2 +parso==0.7.0 +pickleshare==0.7.5 +pipdeptree==0.13.2 +pluggy==0.13.1 +poyo==0.5.0 +prometheus-client==0.7.1 +prompt-toolkit==3.0.5 +py==1.8.1 +pycparser==2.20 +Pygments==2.6.1 +pylru==1.2.0 +pyparsing==2.4.7 +pyperclip==1.6.0 +pyrsistent==0.16.0 +pytest==5.4.1 +python-dateutil==2.8.1 +python-dotenv==0.13.0 +python-libsbml==5.18.0 +python-libsbml-experimental==5.18.0 +python-slugify==4.0.0 +pytz==2019.3 +pywin32==227 +pywinpty==0.5.7 +PyYAML==5.3.1 +pyzmq==19.0.0 +regex==2020.4.4 +requests==2.23.0 +rfc3986==1.4.0 +ruamel.yaml==0.16.10 +ruamel.yaml.clib==0.2.0 +s3transfer==0.3.3 +sbtab==0.9.73 +scipy==1.4.1 +Send2Trash==1.5.0 +simpleeval==0.9.10 +six==1.14.0 +smmap==3.0.2 +snowballstemmer==2.0.0 +Sphinx==3.0.2 +sphinxcontrib-applehelp==1.0.2 +sphinxcontrib-devhelp==1.0.2 +sphinxcontrib-htmlhelp==1.0.3 +sphinxcontrib-jsmath==1.0.1 +sphinxcontrib-qthelp==1.0.3 +sphinxcontrib-serializinghtml==1.1.4 +SQLAlchemy==1.3.16 +statistics==1.0.3.5 +swiglpk==4.65.1 +sympy==1.5.1 +tableschema==1.15.3 +tablib==1.1.0 +tabulator==1.38.2 +terminado==0.8.3 +testpath==0.4.4 +text-unidecode==1.3 +tornado==6.0.4 +tqdm==4.45.0 +traitlets==4.3.3 +travis-encrypt==1.1.2 +unicodecsv==0.14.1 +urllib3==1.25.9 +wcwidth==0.1.9 +webencodings==0.5.1 +wincertstore==0.2 +xlrd==1.2.0 +zipp==3.1.0