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Get mutations from BN and identify resistance #1

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jonbra opened this issue Feb 7, 2024 · 2 comments
Open

Get mutations from BN and identify resistance #1

jonbra opened this issue Feb 7, 2024 · 2 comments

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@jonbra
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jonbra commented Feb 7, 2024

Pros:
The analysis is automatically executed every time a new sample is analysed.

Cons:
May require a lot of extra work just to implement in the routine.
Difficult to re-run or update if new resistance mutations/data is released.

@jonbra
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jonbra commented Feb 7, 2024

Simply create lists of mutations in NSP5, with Stanford-compatible numbering.

Match these against the stanford mutations.

@jonbra jonbra changed the title Should we include the analysis for every new oppsett? Get mutations from BN and identify resistance Feb 7, 2024
@jonbra
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jonbra commented Feb 7, 2024

  • Read the ORF1a (nsp5) and PRF1b (nsp12) mutations directly from BN
  • Convert these mutations to Stanford nomenclature (already have code for) and and store these in separate columns for nsp5 and nsp12.
  • Match the nsp5 and nsp12 columns with the resistance mutations provided by Stanford (see How to get the latest data from Stanford? #2).

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