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<!DOCTYPE html>
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<text font-family="bebas_neuebold" x=344 y=250 font-size=110 font-weight=600 fill="white" style="margin: auto">MC YEAST
<tspan font-family="robotolight" x=60 y=310 font-size=40 fill="white" font-weight=400 style="margin: auto">Stress-based detection and enzymatic degradation</tspan>
<tspan font-family="robotolight" x=170 y=360 font-size=40 fill="white" font-weight=400 style="margin: auto">of the cyanobacterial toxin microcystin</tspan>
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<h1 id="ONE">Introduction</h1>
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<p class="justify" style="font-size:19px;">After <a href="team.html" class="index" style="color:#ff9900">our team's</a> brainstorming sessions, one of the most popular ideas was <a href="project.html" class="index" style="color:#ff9900">targeting cyanobacteria</a> (blue-green algae) since they are a recurring problem in Finland every summer. The toxins produced by blue-green algae are the major problem, since they are harmful to humans and animals. Microcystin-LR (MC-LR) is the most common cyanotoxin in freshwaters; it is a heptapeptide that affects mainly the liver. We consulted a research group at the University of Helsinki focusing on blue-green algae and got more information on the matter. Our extensive research indicated that working on cyanobacteria would be promising. We were also motivated by the fact that this problem was popular in Finland and many Finns could relate to it. Considering all of this, we decided to go ahead with this project. </p>
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<p class="justify" style="font-size:19px;" >The project is focused on the detection and degradation of MC-LR and we designed constructs for both purposes. We also <a href="modelling.html" class="index" style="color:#ff9900">modelled</a> the kinetics of MlrA and the toxicity mechanism of MC-LR. As our <a href="humanpractices.html" class="index" style="color:#ff9900">human practices</a>, we have for example met experts from the Finnish Environment Centre (SYKE) and interviewed local Finns about blue-green algae and their views on synthetic biology. In addition to everything else, we have done some <a href="collaboration.html" class="index" style="color:#ff9900">collaboration</a>, such as building the CollabSeeker, a search engine idea for collaboration which would allow teams of the year to find out about one another and their projects.</p>
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<tspan x=270 y=130 font-size=14 fill="#2F4F4F" font-weight=300>The team started brainstorming in March and after a couple</tspan>
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<h2>What is iGEM?</h2>
<p class="lead spacing justified">
iGEM (International Genetically Engineered Machine) is an annual worldwide Synthetic Biology competition originated at MIT, Boston.
By participating in iGEM, teams of students work together with the goal of identifying and prototyping an engineered genetic machine
that addresses a real-world problem or opportunity. iGEM is based on using BioBricks, standardized genetic parts, and one of
the main goals of the competition is to produce new BioBricks to the collection. iGEM teams are student-driven and responsible for project ideation,
planning, realization as well as their own fundraising.</p>
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<h2>Our Team</h2>
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Aalto-Helsinki 2016 is a multidisciplinary and international team of ten students from Aalto University and University of Helsinki
that the interest in synthetic biology has brought together. Our team has a wide range of study and experience in research, natural sciences
and technology. Aalto-Helsinki has been the first and presently the only team to represent Finland out of an annually increasing number
of more than 250 participating teams across forty countries.</p>
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Toxins produced by blue-green algae are a recurring problem in Finnish lakewaters every summer. When present in large quantities as blooms,
cyanotoxins pose a significant health threat to humans and domestic animals. The goal of our project is to sense and degrade these toxins
by producing cyanotoxin-degrading enzyme with genetically modified yeast. We also want to promote synthetic biology and raise the knowledge
about it.</p>
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