output_examples.json

{
  "lifespan_change": {
    "HGNC": [
      "GHR",
      "GHR",
      "GHR",
      "GHR",
      "GHR"
    ],
    "model_organism": [
      "mouse",
      "mouse",
      "mouse",
      "mouse",
      "mouse"
    ],
    "sex": [
      "male",
      "female",
      "male",
      "female",
      "female"
    ],
    "line": [
      "C57BL/6J",
      "C57BL/6",
      "Ola-BALB/cJ",
      "Ola-BALB/cJ",
      "129/OlaHsd x BALB/c"
    ],
    "effect_on_lifespan": [
      "increases lifespan",
      "increases lifespan",
      "increases lifespan",
      "increases lifespan",
      "increases lifespan"
    ],
    "control_cohort_size": [
      22.0,
      35.0,
      15.0,
      24.0,
      13.0
    ],
    "experiment_cohort_size": [
      14.0,
      35.0,
      11.0,
      30.0,
      11.0
    ],
    "quantity_of_animals_in_cage_or_container": [
      2.0,
      null,
      2.0,
      2.0,
      4.0
    ],
    "containment_t_celsius_from": [
      22.0,
      22.0,
      22.0,
      22.0,
      null
    ],
    "containment_t_celsius_to": [
      null,
      null,
      null,
      null,
      null
    ],
    "diet": [
      "standard chow",
      "standard chow",
      "standard chow",
      "standard chow",
      "standard chow"
    ],
    "target_gene_expression_change": [
      null,
      null,
      null,
      null,
      null
    ],
    "control_lifespan_min": [
      175.0,
      98.6,
      128.0,
      516.0,
      null
    ],
    "control_lifespan_mean": [
      756.0,
      122.0,
      656.0,
      759.0,
      749.0
    ],
    "control_lifespan_median": [
      866.0,
      125.5,
      698.0,
      765.0,
      null
    ],
    "control_lifespan_max": [
      955.0,
      137.8,
      885.0,
      1004.0,
      null
    ],
    "experiment_lifespan_min": [
      686.0,
      94.0,
      648.0,
      525.0,
      null
    ],
    "experiment_lifespan_mean": [
      951.0,
      128.0,
      917.0,
      921.0,
      1031.0
    ],
    "experiment_lifespan_median": [
      941.0,
      124.0,
      888.0,
      981.0,
      null
    ],
    "experiment_lifespan_max": [
      1095.0,
      163.6,
      1165.0,
      1163.0,
      null
    ],
    "lifespan_time_unit": [
      "days",
      "weeks",
      "days",
      "days",
      "days"
    ],
    "lifespan_percent_change_min": [
      292.0,
      -4.7,
      406.2,
      1.7,
      null
    ],
    "significance_min": [
      null,
      null,
      null,
      null,
      null
    ],
    "lifespan_percent_change_mean": [
      26.0,
      5.0,
      40.0,
      21.0,
      38.0
    ],
    "significance_mean": [
      1,
      0,
      1,
      1,
      1
    ],
    "lifespan_percent_change_median": [
      9.0,
      -1.1,
      27.0,
      28.0,
      null
    ],
    "significance_median": [
      null,
      0,
      null,
      null,
      null
    ],
    "lifespan_percent_change_max": [
      14.7,
      18.7,
      31.6,
      15.8,
      null
    ],
    "significance_max": [
      null,
      1,
      null,
      null,
      null
    ],
    "intervention_deteriorates": [
      null,
      "glucose metabolism,body composition",
      null,
      null,
      null
    ],
    "intervention_improves": [
      "insulin sensitivity,glucose metabolism,INS/IGFR pathway",
      "insulin sensitivity",
      "insulin sensitivity,glucose metabolism,INS/IGFR pathway",
      "insulin sensitivity,glucose metabolism,INS/IGFR pathway",
      "INS/IGFR pathway"
    ],
    "main_effect_on_lifespan": [
      "loss of function",
      "loss of function",
      "loss of function",
      "loss of function",
      "loss of function"
    ],
    "intervention_way": [
      "changes in genome level",
      "combined (inducible mutation)",
      "changes in genome level",
      "changes in genome level",
      "changes in genome level"
    ],
    "intervention_method": [
      "gene knockout",
      "gene knockout",
      "gene knockout",
      "gene knockout",
      "gene knockout"
    ],
    "genotype": [
      "-/-",
      "-/-",
      "-/-",
      "-/-",
      "-/-"
    ],
    "tissue": [
      null,
      null,
      null,
      null,
      null
    ],
    "tissue_specific_promoter": [
      null,
      null,
      null,
      null,
      null
    ],
    "induction_by_drug_withdrawal": [
      0,
      0,
      0,
      0,
      0
    ],
    "drug": [
      null,
      "tamoxifen",
      null,
      null,
      null
    ],
    "treatment_start": [
      null,
      "6weeks",
      null,
      "0days",
      null
    ],
    "treatment_end": [
      null,
      "6.7weeks",
      null,
      null,
      null
    ],
    "doi": [
      "10.1210/en.2003-0374",
      "10.1210/en.2016-1649",
      "10.1210/en.2003-0374",
      "10.1210/en.2003-0374",
      "10.1210/endo.141.7.7586"
    ],
    "pmid": [
      null,
      null,
      null,
      null,
      null
    ]
  },
  "gene_criteria": {
    "HGNC": [
      "A2M",
      "AARS1",
      "AASS",
      "ABCA5",
      "ABCA8"
    ],
    "criteria": [
      "'Age-related changes in gene expression, methylation or protein activity'",
      "'Age-related changes in gene expression, methylation or protein activity in humans'",
      "'Age-related changes in gene expression, methylation or protein activity in humans'",
      "'Age-related changes in gene expression, methylation or protein activity in humans'",
      "'Age-related changes in gene expression, methylation or protein activity in humans'"
    ]
  },
  "gene_hallmarks": {
    "HGNC": [
      "A2M",
      "AARS1",
      "AASS",
      "ABCA5",
      "ABCA8"
    ],
    "hallmarks of aging": [
      "'stem cell exhaustion','sterile inflammation'",
      null,
      "'transcriptional alterations','accumulation of reactive oxygen species'",
      null,
      null
    ]
  },
  "longevity_associations": {
    "HGNC": [
      "ABCC4",
      "ABO",
      "ABO",
      "ABO",
      "ABO"
    ],
    "polymorphism type": [
      "SNP",
      "SNP",
      "SNP",
      "SNP",
      "SNP"
    ],
    "polymorphism id": [
      "rs4148544",
      "rs2519093",
      "rs514659",
      "rs545971",
      "rs612169"
    ],
    "nucleotide substitution": [
      "n/a",
      "n/a",
      "A/C",
      "C/T",
      "A/G"
    ],
    "amino acid substitution": [
      "n/a",
      "n/a",
      "n/a",
      "n/a",
      "n/a"
    ],
    "polymorphism \u2014 other": [
      "n/a",
      "n/a",
      "n/a",
      "n/a",
      "n/a"
    ],
    "ethnicity": [
      "Caucasian, American",
      "European",
      "European",
      "European",
      "European"
    ],
    "study type": [
      "GWAS",
      "iGWAS",
      "iGWAS",
      "iGWAS",
      "iGWAS"
    ],
    "sex": [
      "all",
      "all",
      "all",
      "all",
      "all"
    ],
    "doi": [
      "10.1089/rej.2011.1257",
      "10.7554/eLife.39856.001",
      "10.1371/journal.pgen.1005728",
      "10.1371/journal.pgen.1005728",
      "10.1371/journal.pgen.1005728"
    ],
    "pmid": [
      "n/a",
      "n/a",
      "n/a",
      "n/a",
      "n/a"
    ]
  }
}