diff --git a/PDAC data/README.md b/PDAC data/README.md new file mode 100644 index 0000000..efb5558 --- /dev/null +++ b/PDAC data/README.md @@ -0,0 +1,22 @@ +Single-cell analysis of the pancreatic cancer microbiome +================ +Bassel Ghaddar +7/31/2022 + +### Introduction + +We used SAHMI to analyze tumor-microbiome interactions in two pancreatic cancer cohorts: scPDA1 (Peng et al., 2019) and scPDA2 (Steele et al., 2020). + +The processed counts matrices for both datasets as well as SAHMI denoising test reports are included here. + +Please contact Bassel Ghaddar (bassel.ghaddar@gmail.com) or Subhajyoti De (subhajyoti.de@rutgers.edu) for any questions. + +### References +Coming soon. + +Ghaddar, B., Blaser, M.J., and De, S. (2022). Denoising sparse microbial signals from single-cell sequencing of mammalian host tissues. BioRxiv. doi: 10.1101/2022.06.29.498176 + +Peng, J., Sun, B.F., Chen, C.Y., Zhou, J.Y., Chen, Y.S., Chen, H., Liu, L., Huang, D., Jiang, J., Cui, G.S., et al. (2019). Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. Nat. Cell Res. + +Steele, N.G., Carpenter, E.S., Kemp, S.B., Sirihorachai, V.R., The, S., Delrosario, L., Lazarus, J., Amir, E. ad D., Gunchick, V., Espinoza, C., et al. (2020). Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer. Nat. Cancer 1, 1097–1112. + diff --git a/PDAC data/pdac_sahmi.RDS b/PDAC data/pdac_sahmi.RDS new file mode 100644 index 0000000..658c438 Binary files /dev/null and b/PDAC data/pdac_sahmi.RDS differ diff --git a/PDAC data/peng_microbiome.RDS b/PDAC data/peng_microbiome.RDS new file mode 100644 index 0000000..b7bb64c Binary files /dev/null and b/PDAC data/peng_microbiome.RDS differ diff --git a/PDAC data/steele_microbiome.RDS b/PDAC data/steele_microbiome.RDS new file mode 100644 index 0000000..1b57478 Binary files /dev/null and b/PDAC data/steele_microbiome.RDS differ