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PDAC data/README.md

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+Single-cell analysis of the pancreatic cancer microbiome 
+================
+Bassel Ghaddar
+7/31/2022
+
+### Introduction
+
+We used SAHMI to analyze tumor-microbiome interactions in two pancreatic cancer cohorts: scPDA1 (Peng et al., 2019) and scPDA2 (Steele et al., 2020). 
+
+The processed counts matrices for both datasets as well as SAHMI denoising test reports are included here. 
+
+Please contact Bassel Ghaddar ([email protected]) or Subhajyoti De ([email protected]) for any questions. 
+
+### References
+Coming soon.
+
+Ghaddar, B., Blaser, M.J., and De, S. (2022). Denoising sparse microbial signals from single-cell sequencing of mammalian host tissues. BioRxiv. doi: 10.1101/2022.06.29.498176
+
+Peng, J., Sun, B.F., Chen, C.Y., Zhou, J.Y., Chen, Y.S., Chen, H., Liu, L., Huang, D., Jiang, J., Cui, G.S., et al. (2019). Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. Nat. Cell Res.
+
+Steele, N.G., Carpenter, E.S., Kemp, S.B., Sirihorachai, V.R., The, S., Delrosario, L., Lazarus, J., Amir, E. ad D., Gunchick, V., Espinoza, C., et al. (2020). Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer. Nat. Cancer 1, 1097–1112.
+